Current Duke Appointments & Affiliations
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Duke Clinical Research Institute,
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Recent Scholarly Works
Early trajectories of virological and immunological biomarkers and clinical outcomes in patients admitted to hospital for COVID-19: an international, prospective cohort study.
Journal article The Lancet. Microbe · June 2024 BackgroundSerial measurement of virological and immunological biomarkers in patients admitted to hospital with COVID-19 can give valuable insight into the pathogenic roles of viral replication and immune dysregulation. We aimed to characterise bio ... Full text CiteEffect of Neutralizing Monoclonal Antibody Treatment on Early Trajectories of Virologic and Immunologic Biomarkers in Patients Hospitalized With COVID-19.
Journal article The Journal of infectious diseases · March 2024 BackgroundNeutralizing monoclonal antibodies (nmAbs) failed to show clear benefit for hospitalized patients with coronavirus disease 2019 (COVID-19). Dynamics of virologic and immunologic biomarkers remain poorly understood.MethodsPartici ... Full text CiteIntravenous aviptadil and remdesivir for treatment of COVID-19-associated hypoxaemic respiratory failure in the USA (TESICO): a randomised, placebo-controlled trial.
Journal article Lancet Respir Med · September 2023 BACKGROUND: There is a clinical need for therapeutics for COVID-19 patients with acute hypoxemic respiratory failure whose 60-day mortality remains at 30-50%. Aviptadil, a lung-protective neuropeptide, and remdesivir, a nucleotide prodrug of an adenosine a ... Full text Link to item CiteRecent Grants
1/2 IMPRoving Outcomes in Vascular DisEase - Aortic Dissection (IMPROVE-AD)
ResearchCEC Clinical Trials Assistant · Awarded by National Heart, Lung, and Blood Institute · 2024 - 2030Score Validation
ResearchStatistical Team · Awarded by Inova Health Care Services · 2025 - 2027View All Grants