Scholars@Duke
Heather Elizabeth Whitson

Heather Elizabeth Whitson

Duke School of Medicine Distinguished Professor in Neuroscience
Medicine, Geriatrics and Palliative Care
Duke Box 3003, Durham, NC 27710
Dept of Medicine, Durham, NC 27710

Scholarly Works - Journal articles

Comparing two methods to quantify physical resilience.

Journal article J Frailty Aging · June 20, 2026 Physical resilience, conceptualized as the extent of observed recovery after a health stressor, is an important construct in research on aging and frailty. Various methods have been proposed to quantify physical resilience using repeated measures of health ... Full text Link to item Cite

Frailty phenotype in adults with sickle cell disease.

Journal article J Gerontol A Biol Sci Med Sci · May 7, 2026 BACKGROUND: People with sickle cell disease (SCD) are at risk for accelerated biological aging and functional decline due to both age and SCD-related stressors. Frailty is characterized by decreased physiologic reserve and increased vulnerability to stress ... Full text Link to item Cite

Living Memory Home for Dementia Care Pairs (LMH-4-DCP): study protocol for a pilot randomized trial of a web-based reminiscence intervention for family caregivers and persons with dementia.

Journal article Pilot Feasibility Stud · April 14, 2026 BACKGROUND: Family caregivers provide most of the emotional, physical, and logistical support for people living with Alzheimer's disease and related dementias (ADRD). As the caregiving role intensifies with advancing illness, family caregivers navigate the ... Full text Link to item Cite

Clinical predictors of resilience following total knee arthroplasty: the PRIME-KNEE study.

Journal article J Gerontol A Biol Sci Med Sci · April 7, 2026 BACKGROUND: We aimed to describe recovery trajectories over 6 months in pain intensity, pain interference, lower extremity disability, and physical activity in older adults undergoing elective total knee arthroplasty (TKA), and to identify clinically feasi ... Full text Link to item Cite

Cerebrospinal fluid amyloid-β 42/40 ratio is associated with ganglion cell-inner plexiform layer thinning in individuals with and without amyloid pathology.

Journal article J Alzheimers Dis · April 2026 BackgroundRetinal imaging offers a noninvasive window into neurodegenerative changes, yet its relationship with established cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) remains poorly understood. This study addresses a critical gap by e ... Full text Link to item Cite

Digital Reminiscence for Predeath Grief Among Family Caregivers of Patients With Dementia: A Pilot Randomized Clinical Trial.

Journal article JAMA Netw Open · April 1, 2026 IMPORTANCE: Family caregiving for individuals with Alzheimer disease and related dementias (ADRD) is associated with significant distress related to physical, emotional, and interpersonal losses. Reminiscence therapy may help family caregivers preserve con ... Full text Link to item Cite

Olfactory cleft biopsy analysis of Alzheimer's disease pathobiology across disease stages.

Journal article Nat Commun · March 18, 2026 Alzheimer's Disease (AD) is a neurodegenerative condition affecting millions worldwide. Defining early pathobiological events remains challenging, in part due to inaccessibility of neural tissue. Because olfactory neurons are accessible, and olfactory loss ... Full text Link to item Cite

Summary population attributable fraction of dementia prevalence associated with sensory risk factors.

Journal article J Alzheimers Dis · March 2026 BackgroundHearing and vision loss can be treatable sensory risk factors for dementia. Nationally-representative estimates of the proportion of dementia prevalence associated with sensory risk factors in late-life are needed for dementia prevention strategi ... Full text Link to item Cite

Prevalence of pre-stroke and stroke-related vision impairments and their association with mild cognitive impairment and dementia.

Journal article J Alzheimers Dis · March 2026 BackgroundVision impairment is a risk factor for mild cognitive impairment (MCI) among stroke survivors, but it is unclear if this association is driven by vision impairment present before or due to the stroke, and if similar associations exist with dement ... Full text Link to item Cite

Translational Methods for Wearable Heart Rate Variability Monitoring in Older Adults: Preoperative Risk Stratification and Postoperative Monitoring.

Journal article J Cardiovasc Transl Res · February 5, 2026 Low preoperative heart rate variability (HRV) is associated with adverse cardiovascular outcomes and delirium after geriatric surgery, but in-person testing is burdensome and impractical. To evaluate wrist-based wearables for remotely capturing preoperativ ... Full text Link to item Cite

Mixed-methods Analysis of Preoperative Distress and Postoperative Outcomes in a Prospective, Observational Cohort of Older Adults.

Journal article Anesthesiology · January 1, 2026 BACKGROUND: The effect of psychological distress on general geriatric surgery outcomes remains unexplored despite recommendations for routine, preoperative distress screening. This study aimed to assess preoperative distress measures in a general geriatric ... Full text Link to item Cite

Higher spatial resolution diffusion-weighted imaging improves characterization of white matter disconnection in Alzheimer's disease.

Journal article Imaging Neurosci (Camb) · 2026 In addition to the accumulation of neuropathologies (i.e., amyloid beta, neurofibrillary tangles), Alzheimer's disease (AD) is associated with the degradation of white matter (WM) structural pathways that connect distributed brain regions. However, previou ... Full text Open Access Link to item Cite

Investigating stroke-related vision impairments and time to incident dementia diagnosis.

Journal article J Stroke Cerebrovasc Dis · December 2025 Vision loss is a risk factor for dementia, but it is unknown whether stroke-related vision impairment is linked to dementia risk in stroke survivors. This secondary analysis aimed to quantify the association between stroke-related vision impairment and tim ... Full text Link to item Cite

Developing Topics.

Journal article Alzheimers Dement · December 2025 BACKGROUND: Postoperative delirium (POD), characterized by acute fluctuations in consciousness and attention, is associated with increased risk of Alzheimer's disease and related dementias. However, the neural mechanisms underlying attention impairments in ... Full text Link to item Cite

Biomarkers.

Journal article Alzheimers Dement · December 2025 BACKGROUND: Psychosocial factors, including mood function and residential status (urban vs. rural), have been suggested to affect the risk of Alzheimer's Disease and Related Dementias (ADRD). Few studies, however, have attempted to examine the associations ... Full text Link to item Cite

Biomarkers.

Journal article Alzheimers Dement · December 2025 BACKGROUND: Cerebrospinal fluid (CSF) biomarkers for Alzheimer's Disease and Related Dementias (ADRD) have gained widespread usage in clinical diagnosis and treatment, but their utility among middle-aged individuals has yet to be fully elucidated. We exami ... Full text Link to item Cite

Biomarkers.

Journal article Alzheimers Dement · December 2025 BACKGROUND: Worse sensory and physical function measures associate with higher risk of Alzheimer's Disease and Related Dementias (ADRD). To our knowledge, no studies have reported relationships between sensory and physical function, ADRD cerebrospinal flui ... Full text Link to item Cite

Public Health.

Journal article Alzheimers Dement · December 2025 BACKGROUND: Anti-amyloid monoclonal antibodies (lecanemab and donanemab) received full approval by the FDA to treat early Alzheimer's disease and entered routine clinical practice in July 2023 and July 2024 respectively. Uptake patterns and post-approval s ... Full text Link to item Cite

Developing Topics.

Journal article Alzheimers Dement · December 2025 BACKGROUND: In recent years, blood-based biomarkers (BBMs) have transformed the diagnostic landscape of Alzheimer's disease (AD), with some now approaching readiness for clinical implementation. This progress aligns with the growing importance of accurate ... Full text Link to item Cite

Perioperative Bottom‐Up vs. Top‐Down Attention Impairments in Postoperative Delirium

Journal article Alzheimer's & dementia : the journal of the Alzheimer's Association · December 2025 Cite

Sensory and Physical Function Associate with Cognition and Biomarkers for Alzheimer's Disease and Related Dementias Across the Lifespan

Journal article Alzheimer's & dementia : the journal of the Alzheimer's Association · December 2025 Open Access Cite

Demographic and Clinical Correlates of Biomarkers for Alzheimer's Disease and Related Dementias in the Duke‐UNC ADRC

Journal article Alzheimer's & dementia : the journal of the Alzheimer's Association · December 2025 Cite

Characteristics and Safety Outcomes of Patients Treated with Lecanemab or Donanemab in Routine Clinical Practice: A Nationwide Study

Journal article Alzheimer's & dementia : the journal of the Alzheimer's Association · December 2025 Cite

Blood-based biomarkers for detecting Alzheimer's disease pathology in cognitively impaired individuals within specialized care settings: A systematic review and meta-analysis.

Journal article Alzheimers Dement · November 2025 BACKGROUND: This systematic review and meta-analysis aimed to assess the diagnostic test accuracy of blood-based biomarkers (BBMs) for detecting Alzheimer's disease (AD) pathology in cognitively impaired individuals in specialized care settings. The overar ... Full text Link to item Cite

CMV-specific clonal expansion of Th1, GZMK+ CD8+, and TEMRA T cells revealed by human PBMC single cell profiling.

Journal article bioRxiv · October 18, 2025 Cytomegalovirus (CMV) is a common herpesvirus that establishes lifelong latency and becomes increasingly prevalent with age. We systematically characterized CMV-associated immune remodeling by analyzing six human cohorts (two newly built) using single-cell ... Full text Link to item Cite

Associations between anaesthetic dose-adjusted intraoperative EEG alpha power, processing speed, and postoperative delirium: analysis of data from three prospective studies.

Journal article Br J Anaesth · July 2025 BACKGROUND: We previously have shown that low intraoperative EEG alpha power is associated with impaired preoperative cognition, a delirium risk factor, and that intraoperative anaesthetic-dose-adjusted EEG bispectral index values were associated with a fo ... Full text Link to item Cite

Alzheimer's Association Clinical Practice Guideline on the use of blood-based biomarkers in the diagnostic workup of suspected Alzheimer's disease within specialized care settings.

Journal article Alzheimers Dement · July 2025 OBJECTIVE AND SCOPE: A panel of clinicians, subject-matter experts, and guideline methodologists convened by the Alzheimer's Association conducted a systematic review and formulated evidence-based recommendations for using blood-based biomarkers (BBMs) in ... Full text Link to item Cite

The Association of Vision and Hearing Impairment on Cognitive Function and Loneliness: Evidence From the Mexican Health and Aging Study.

Journal article J Aging Health · June 2025 Objectives: We investigated whether self-reported vision and hearing were associated with cognitive function and loneliness among Mexican adults aged 50 and older. Methods: Mexican Health and Aging Study data. Vision/hearing status was self-reported (excel ... Full text Open Access Link to item Cite

Psychological Resilience and Physical Function in Veterans With Chronic Kidney Disease: A Brief Report.

Journal article J Am Geriatr Soc · June 2025 BACKGROUND: Psychological resilience has been characterized as the ability to recover from stressful life events. Not well studied is whether self-reported measures of psychological resilience are associated with physical function recovery. Therefore, we e ... Full text Link to item Cite

Proceedings of the Alzheimer's Diagnosis in Older Adults With Chronic Conditions Network Inaugural Annual Conference.

Journal article J Gerontol A Biol Sci Med Sci · May 5, 2025 The Alzheimer's Disease in Older Adults with Chronic Conditions (ADACC) Network is funded by the National Institute on Aging as a U24 cooperative agreement. ADACC is an inclusive, multidisciplinary group across multiple institutions that is charged with th ... Full text Link to item Cite

Research Best Practices for Eye Stroke Vision Rehabilitation: A Qualitative Study.

Journal article Curr Eye Res · May 2025 PURPOSE: Central retinal artery occlusion, also known as an eye stroke, results in visual impairment and functional challenges. Our study objectives were to identify meaningful measures and factors that indicate or enable successful recovery after eye stro ... Full text Link to item Cite

Stress tests and biomarkers of resilience: Proceedings of the second state of resilience science conference.

Journal article J Am Geriatr Soc · April 2025 The "Stress Tests and Biomarkers of Resilience" conference, hosted by the American Geriatrics Society and the National Institute on Aging, marks the second in a series aimed at advancing the field of resilience science. Held on March 4-5, 2024, in Bethesda ... Full text Link to item Cite

Genetic and biomarker disclosure process in a memory and aging study.

Journal article J Alzheimers Dis · March 2025 Despite growing awareness that disclosing biomarker results to research participants is aligned with ethical principles of researcher-participant partnership, there are currently no widely adopted guidelines for this disclosure in Alzheimer's disease resea ... Full text Link to item Cite

Selecting Appropriate Clinical Trial Endpoints for Geroscience Trials: A Path Towards Consensus.

Journal article Res Sq · February 12, 2025 Using a modified Delphi process, we engaged 28 experts in clinical trials, geriatrics, and research translation to determine if there were consensus around what clinical endpoints should be used for trials evaluating the efficacy of interventions to preven ... Full text Link to item Cite

Predilection for Perplexion: Preoperative microstructural damage is linked to postoperative delirium.

Journal article medRxiv · January 9, 2025 Postoperative delirium is the most common postsurgical complication in older adults and is associated with an increased risk of long-term cognitive decline and Alzheimer's disease (AD) and related dementias (ADRD). However, the neurological basis of this i ... Full text Open Access Link to item Cite

The Role of Sleep Apnea in Postoperative Neurocognitive Disorders Among Older Noncardiac Surgery Patients: A Prospective Cohort Study.

Journal article Anesth Analg · January 1, 2025 BACKGROUND: Obstructive sleep apnea is associated with increased dementia risk, yet its role in postoperative neurocognitive disorders is unclear. Here, we studied whether the severity of untreated obstructive sleep apnea is associated with the severity of ... Full text Open Access Link to item Cite

Predicting risk of impending cognitive decline in asymptomatic individuals with early Alzheimer's disease: Insights from cortical diffusion MRI.

Journal article Imaging Neurosci (Camb) · 2025 Neurodegeneration associated with Alzheimer's disease (AD) can start at the microstructural level years before cognitive symptoms; yet, it has been difficult to definitively detect these early changes to plan effective treatments. Using a cortical column-b ... Full text Open Access Link to item Cite

Traffic-related air pollution significantly aggravates the detrimental effect of infections on the risk of Alzheimer's disease and other dementias, especially in non-carriers of APOE4.

Journal article Front Dement · 2025 Alzheimer's disease (AD) is a complex neurodegenerative disorder influenced by various factors, including genetic and exposure-related. Certain combinations of these factors may promote AD more substantially than others. APOE4 is the strongest genetic risk ... Full text Link to item Cite

Vision Impairment and the Population Attributable Fraction of Dementia in Older Adults.

Journal article JAMA Ophthalmol · October 1, 2024 IMPORTANCE: Vision impairment is a potentially modifiable risk factor for dementia. Although few prior studies have estimated the contribution of vision impairments to dementia, none have reported on multiple objectively measured vision impairments (eg, di ... Full text Link to item Cite

Trajectories of Physical Resilience Among Older Veterans With Stage 4 CKD.

Journal article Am J Kidney Dis · August 2024 RATIONALE & OBJECTIVE: Although functional impairment is common among older adults with chronic kidney disease (CKD), functional reserve before an acute health event and physical resilience after the event have not been characterized in this population. Th ... Full text Link to item Cite

DNA methylation of imprint control regions associated with Alzheimer's disease in non-Hispanic Blacks and non-Hispanic Whites.

Journal article Clin Epigenetics · April 25, 2024 Alzheimer's disease (AD) prevalence is twice as high in non-Hispanic Blacks (NHBs) as in non-Hispanic Whites (NHWs). The objective of this study was to determine whether aberrant methylation at imprint control regions (ICRs) is associated with AD. Differen ... Full text Link to item Cite

New approaches for understanding the potential role of microbes in Alzheimer's disease.

Journal article Brain Behav Immun Health · March 2024 Alzheimer's disease (AD) involves a complex pathological process that evolves over years, and its etiology is understood as a classic example of gene-environment interaction. The notion that exposure to microbial organisms may play some role in AD patholog ... Full text Link to item Cite

Accelerated Brain Atrophy, Microstructural Decline and Connectopathy in Age-Related Macular Degeneration.

Journal article Biomedicines · January 10, 2024 Age-related macular degeneration (AMD) has recently been linked to cognitive impairment. We hypothesized that AMD modifies the brain aging trajectory, and we conducted a longitudinal diffusion MRI study on 40 participants (20 with AMD and 20 controls) to r ... Full text Open Access Link to item Cite

Preoperative electroencephalographic alpha-power changes with eyes opening are associated with postoperative attention impairment and inattention-related delirium severity.

Journal article Br J Anaesth · January 2024 BACKGROUND: In the eyes-closed, awake condition, EEG oscillatory power in the alpha band (7-13 Hz) dominates human spectral activity. With eyes open, however, EEG alpha power substantially decreases. Less alpha attenuation with eyes opening has been associ ... Full text Link to item Cite

Patterns of Aging Changes in Bodyweight May Predict Alzheimer's Disease.

Journal article J Alzheimers Dis · 2024 Relationships between patterns of aging-changes in bodyweight and AD are not fully understood. We compared mean age-trajectories of weight between those who did and did not develop late-onset-AD, and evaluated impact of age at maximum weight (AgeMax), and ... Full text Link to item Cite

Anti-CMV IgG Seropositivity is Associated with Plasma Biomarker Evidence of Amyloid-β Accumulation.

Journal article J Alzheimers Dis · 2024 BACKGROUND: Some human studies have identified infection with cytomegalovirus (CMV), a member of the alpha herpesvirus family, as a risk factor for Alzheimer's disease and related dementias (ADRD). To our knowledge, no studies have evaluated associations o ... Full text Link to item Cite

Role of Blood-Brain Barrier Dysfunction in Delirium following Non-cardiac Surgery in Older Adults.

Journal article Ann Neurol · December 2023 OBJECTIVE: Although animal models suggest a role for blood-brain barrier dysfunction in postoperative delirium-like behavior, its role in postoperative delirium and postoperative recovery in humans is unclear. Thus, we evaluated the role of blood-brain bar ... Full text Link to item Cite

Trends and risk factors among adults admitted to the emergency department with fall-related eye injuries.

Journal article Am J Emerg Med · December 2023 BACKGROUND/PURPOSE: Eye injuries can happen to people of any age and for many reasons; among these is a fall. The aims of this study were to: (1) examine trends among fall-related eye injuries in working-age and older adults admitted to the emergency depar ... Full text Link to item Cite

Navigating and diagnosing cognitive frailty in research and clinical domains.

Journal article Nat Aging · November 2023 While physical frailty has been recognized as a clinical entity for some time, the concept of cognitive frailty (CF) is now gaining increasing attention in the geriatrics research community. CF refers to the co-occurrence of physical frailty and cognitive ... Full text Link to item Cite

In vivo cortical diffusion imaging relates to Alzheimer's disease neuropathology.

Journal article Alzheimers Res Ther · October 4, 2023 BACKGROUND: There has been increasing interest in cortical microstructure as a complementary and earlier measure of neurodegeneration than macrostructural atrophy, but few papers have related cortical diffusion imaging to post-mortem neuropathology. This s ... Full text Link to item Cite

Ageing and physical resilience after health stressors.

Journal article Stress Health · September 2023 The objectives of this article are to introduce a conceptual framework for physical resilience in the context of ageing and to discuss key elements and challenges in the design of studies of physical resilience after health stressors. Advancing age is asso ... Full text Link to item Cite

An overview of the resilience world: Proceedings of the American Geriatrics Society and National Institute on Aging State of Resilience Science Conference.

Journal article J Am Geriatr Soc · August 2023 Resilience, which relates to one's ability to respond to stressors, typically declines with age and the development of comorbid conditions in older organisms. Although progress has been made to improve our understanding of resilience in older adults, disci ... Full text Link to item Cite

Perioperative changes in neurocognitive and Alzheimer's disease-related cerebrospinal fluid biomarkers in older patients randomised to isoflurane or propofol for anaesthetic maintenance.

Journal article Br J Anaesth · August 2023 BACKGROUND: Animal studies have shown that isoflurane and propofol have differential effects on Alzheimer's disease (AD) pathology and memory, although it is unclear whether this occurs in humans. METHODS: This was a nested randomised controlled trial with ... Full text Link to item Cite

A Role for Blood-brain Barrier Dysfunction in Delirium following Non-Cardiac Surgery in Older adults.

Journal article medRxiv · May 10, 2023 OBJECTIVE: Although animal models suggest a role for blood-brain barrier dysfunction in postoperative delirium-like behavior, its role in postoperative delirium and postoperative recovery in humans is unclear. Thus, we evaluated the role of blood-brain bar ... Full text Link to item Cite

Tryptophan Metabolism and Neurodegeneration: Longitudinal Associations of Kynurenine Pathway Metabolites with Cognitive Performance and Plasma Alzheimer's Disease and Related Dementias Biomarkers in the Duke Physical Performance Across the LifeSpan Study.

Journal article J Alzheimers Dis · 2023 BACKGROUND: The kynurenine pathway (KP) comprises a family of tryptophan-derived metabolites that some studies have reported are associated with poorer cognitive performance and an increased risk of Alzheimer's disease and related dementias (ADRD). OBJECTI ... Full text Open Access Link to item Cite

Assessment and Management of Appetite Loss in Older Adults: An ICFSR Task Force Report.

Journal article J Frailty Aging · 2023 The Appetite loss in older people is an important unmet clinical need in geriatrics. The International Conference on Frailty and Sarcopenia Research (ICFSR) organized a Task Force on April 20th 2022, in Boston, to discuss issues related to appetite loss in ... Full text Link to item Cite

Interactions between genes involved in physiological dysregulation and axon guidance: role in Alzheimer's disease.

Journal article Front Genet · 2023 Dysregulation of physiological processes may contribute to Alzheimer's disease (AD) development. We previously found that an increase in the level of physiological dysregulation (PD) in the aging body is associated with declining resilience and robustness ... Full text Link to item Cite

Vaccination Against Pneumonia May Provide Genotype-Specific Protection Against Alzheimer's Disease.

Journal article J Alzheimers Dis · 2023 Vaccine repurposing that considers individual genotype may aid personalized prevention of Alzheimer's disease (AD). In this retrospective cohort study, we used Cardiovascular Health Study data to estimate associations of pneumococcal polysaccharide vaccine ... Full text Link to item Cite

Engineering Virtuous health habits using Emotion and Neurocognition: Flexibility for Lifestyle Optimization and Weight management (EVEN FLOW).

Journal article Front Aging Neurosci · 2023 Interventions to preserve functional independence in older adults are critically needed to optimize 'successful aging' among the large and increasing population of older adults in the United States. For most aging adults, the management of chronic diseases ... Full text Open Access Link to item Cite

Reserve and resilience in CKD: concept introduction and baseline results from the Physical REsilience Prediction in Advanced REnal Disease (PREPARED) study.

Journal article BMC Nephrol · December 31, 2022 BACKGROUND: The purpose of this manuscript is to introduce reserve and resilience as novel concepts in chronic kidney disease (CKD) research and present baseline data from a unique prospective cohort study designed to characterize recovery from functional ... Full text Link to item Cite

AGS and NIA bench-to bedside conference summary: Cancer and cardiovascular disease.

Journal article J Am Geriatr Soc · October 2022 This report summarizes the presentations, discussions, and recommendations of the most recent American Geriatrics Society and National Institute on Aging research conference, "Cancer and Cardiovascular Disease," on October 18-19, 2021. The purpose of this ... Full text Link to item Cite

Assessing the Clinical Meaningfulness of the Alzheimer's Disease Composite Score (ADCOMS) Tool.

Journal article Neurol Ther · September 2022 INTRODUCTION: The Alzheimer's Disease Composite Score (ADCOMS) is a tool developed to detect clinical progression and measure treatment effect in patients in early stages of Alzheimer's disease (AD). The psychometric properties of the ADCOMS have been esta ... Full text Link to item Cite

Longitudinal Analysis of the Retina and Choroid in Cognitively Normal Individuals at Higher Genetic Risk of Alzheimer Disease.

Journal article Ophthalmol Retina · July 2022 PURPOSE: To assess the baseline differences and longitudinal rate of change in retinal and choroidal imaging parameters between apolipoprotein ε4 (APOE ε4) carriers and noncarriers with normal cognition. DESIGN: Prospective study. SUBJECTS: Four hundred th ... Full text Link to item Cite

Infection and inflammation: New perspectives on Alzheimer's disease.

Journal article Brain Behav Immun Health · July 2022 Neuroinflammation has been recognized as a component of Alzheimer's Disease (AD) pathology since the original descriptions by Alois Alzheimer and a role for infections in AD pathogenesis has long been hypothesized. More recently, this hypothesis has gained ... Full text Link to item Cite

Addition of Vision Impairment to a Life-Course Model of Potentially Modifiable Dementia Risk Factors in the US.

Journal article JAMA Neurol · June 1, 2022 IMPORTANCE: Dementia prevention is a high priority, given the large impact of dementia on the well-being of individuals and society. The number of older adults with dementia in the US and globally is projected to increase as a result of population aging an ... Full text Link to item Cite

Unintended Consequences of COVID-19 Social Distancing Among Older Adults With Kidney Disease.

Journal article J Gerontol A Biol Sci Med Sci · April 1, 2022 BACKGROUND: While social distancing policies protect older adults with advanced chronic kidney disease (CKD) from exposure to COVID-19, reduced social interaction may also have unintended consequences. METHODS: To identify subgroups of patients at risk for ... Full text Link to item Cite

Postoperative changes in cognition and cerebrospinal fluid neurodegenerative disease biomarkers.

Journal article Ann Clin Transl Neurol · February 2022 OBJECTIVE: Numerous investigators have theorized that postoperative changes in Alzheimer's disease neuropathology may underlie postoperative neurocognitive disorders. Thus, we determined the relationship between postoperative changes in cognition and cereb ... Full text Open Access Link to item Cite

Vision impairment and cognitive decline among older adults: a systematic review.

Journal article BMJ Open · January 6, 2022 OBJECTIVES: There has been increasing epidemiological research examining the association between vision impairment (VI) and cognitive impairment and how poor vision may be a modifiable risk factor for cognitive decline. The objective of this systematic rev ... Full text Link to item Cite

Relationship Between Depression/Anxiety and Cognitive Function Before and 6 Weeks After Major Non-Cardiac Surgery in Older Adults.

Journal article J Geriatr Psychiatry Neurol · January 2022 OBJECTIVE: To determine the relationship between affective measures and cognition before and after non-cardiac surgery in older adults. METHODS: Observational prospective cohort study in 103 surgical patients age ≥ 60 years old. All participants underwent ... Full text Link to item Cite

A Processed Electroencephalogram-Based Brain Anesthetic Resistance Index Is Associated With Postoperative Delirium in Older Adults: A Dual Center Study.

Journal article Anesth Analg · January 1, 2022 BACKGROUND: Some older adults show exaggerated responses to drugs that act on the brain. The brain's response to anesthetic drugs is often measured clinically by processed electroencephalogram (EEG) indices. Thus, we developed a processed EEG-based measure ... Full text Link to item Cite

Evaluating the Association Between Hearing Loss and Falls in Adults With Vestibular Dysfunction or Nonvestibular Dizziness.

Journal article Ear Hear · 2022 OBJECTIVES: Although emerging evidence suggests that hearing loss (HL) is an independent risk factor for falls, it is unclear how HL may impact falls risk in adults with vestibular dysfunction and nonvestibular dizziness. The purpose of this study was to c ... Full text Link to item Cite

Resilience: Biological Basis and Clinical Significance - A Perspective Report from the International Conference on Frailty and Sarcopenia Research (ICFSR) Task Force.

Journal article J Frailty Aging · 2022 The Resilience is a construct receiving growing attention from the scientific community in geriatrics and gerontology. Older adults show extremely heterogeneous (and often unpredictable) responses to stressors. Such heterogeneity can (at least partly) be e ... Full text Link to item Cite

Perioperative neurocognitive and functional neuroimaging trajectories in older APOE4 carriers compared with non-carriers: secondary analysis of a prospective cohort study.

Journal article Br J Anaesth · December 2021 BACKGROUND: Cognitive dysfunction after surgery is a major issue in older adults. Here, we determined the effect of APOE4 on perioperative neurocognitive function in older patients. METHODS: We enrolled 140 English-speaking patients ≥60 yr old scheduled fo ... Full text Open Access Link to item Cite

A template for physical resilience research in older adults: Methods of the PRIME-KNEE study.

Journal article J Am Geriatr Soc · November 2021 BACKGROUND: Older adults with similar health conditions often experience widely divergent outcomes following health stressors. Variable recovery after a health stressor may be due in part to differences in biological mechanisms at the molecular, cellular, ... Full text Link to item Cite

Subgroups of High-Risk Veterans Affairs Patients Based on Social Determinants of Health Predict Risk of Future Hospitalization.

Journal article Med Care · May 1, 2021 OBJECTIVE: Population segmentation has been recognized as a foundational step to help tailor interventions. Prior studies have predominantly identified subgroups based on diagnoses. In this study, we identify clinically coherent subgroups using social dete ... Full text Link to item Cite

Succeeding in Aging Research During the Pandemic: Strategies for Fellows and Junior Faculty.

Journal article J Am Geriatr Soc · January 2021 Fellows and junior faculty conducting aging research have encountered substantial new challenges during the COVID-19 pandemic. They report that they have been uncertain how and whether to modify existing research studies, have faced difficulties with job s ... Full text Link to item Cite

Cerebral white matter connectivity, cognition, and age-related macular degeneration.

Journal article Neuroimage Clin · 2021 Age-related macular degeneration (AMD) is a common retina disease associated with cognitive impairment in older adults. The mechanism(s) that account for the link between AMD and cognitive decline remain unclear. Here we aim to shed light on this issue by ... Full text Open Access Link to item Cite

Electroencephalogram-Based Complexity Measures as Predictors of Post-operative Neurocognitive Dysfunction.

Journal article Front Syst Neurosci · 2021 Physiologic signals such as the electroencephalogram (EEG) demonstrate irregular behaviors due to the interaction of multiple control processes operating over different time scales. The complexity of this behavior can be quantified using multi-scale entrop ... Full text Open Access Link to item Cite

Relationship between neural functional connectivity and memory performance in age-related macular degeneration.

Journal article Neurobiol Aging · November 2020 Age-related macular degeneration (AMD) has been linked to memory deficits, with no established neural mechanisms. We collected resting-state brain functional magnetic resonance imaging and standardized verbal recall tests from 42 older adults with AMD and ... Full text Open Access Link to item Cite

Hospitalization Risk Among Older Adults with Sensory Impairments: Development of a Prognostic Model.

Journal article J Am Geriatr Soc · November 2020 OBJECTIVES: To develop a prognostic model for hospital admissions over a 1-year period among community-dwelling older adults with self-reported hearing and/or vision impairments based on readily obtainable clinical predictors. DESIGN: Retrospective cohort ... Full text Link to item Cite

Association Between Dysphagia and Inpatient Outcomes Across Frailty Level Among Patients ≥ 50 Years of Age.

Journal article Dysphagia · October 2020 Frail patients may have heightened risk of dysphagia, a potentially modifiable health factor. Our aim is to examine whether the relationship between dysphagia and adverse health outcomes differs by frailty conditions among inpatients ≥ 50 years of age. Med ... Full text Link to item Cite

Patient-Reported Social and Behavioral Determinants of Health and Estimated Risk of Hospitalization in High-Risk Veterans Affairs Patients.

Journal article JAMA Netw Open · October 1, 2020 IMPORTANCE: Despite recognition of the association between individual social and behavioral determinants of health (SDH) and patient outcomes, little is known regarding the value of SDH in explaining variation in outcomes for high-risk patients. OBJECTIVE: ... Full text Link to item Cite

Biomarkers Associated with Physical Resilience After Hip Fracture.

Journal article J Gerontol A Biol Sci Med Sci · September 25, 2020 BACKGROUND: Clinically similar older adults demonstrate variable responses to health stressors, heterogeneity attributable to differences in physical resilience. However, molecular mechanisms underlying physical resilience are unknown. We previously derive ... Full text Link to item Cite

Aging With Vision Loss: A Framework for Assessing the Impact of Visual Impairment on Older Adults.

Journal article Gerontologist · August 14, 2020 There is limited research examining the impact of visual impairment (VI) on older adults while considering the complexities of aging, leaving gaps in our understanding of how health consequences of VI might be averted. We created a framework integrating co ... Full text Link to item Cite

Determinants of Maintenance and Recovery of Function in a Representative Older Community-Resident Biracial Sample.

Journal article J Am Med Dir Assoc · August 2020 OBJECTIVES: Focus on decline in performance of activities of daily living (ADL) has not been matched by studies of recovery of function. Advised by a broad conceptual model of physical resilience, we ascertain characteristics that identify (1) maintenance, ... Full text Link to item Cite

Use of the ICD-10 vision codes to study ocular conditions in Medicare beneficiaries with stroke.

Journal article BMC Health Serv Res · July 8, 2020 BACKGROUND: Ocular conditions are common following stroke and frequently occur in combination with pre-existing ophthalmologic disease. The Medicare International Statistical Classification of Diseases and Related Health Problems (ICD-10) coding system for ... Full text Link to item Cite

A protocol to reduce self-reported pain scores and adverse events following lumbar punctures in older adults.

Journal article J Neurol · July 2020 OBJECTIVE: Lumbar punctures (LPs) are important for obtaining CSF in neurology studies but are associated with adverse events and feared by many patients. We determined adverse event rates and pain scores in patients prospectively enrolled in two cohort st ... Full text Link to item Cite

Cognitive Impairment among Veterans in Outpatient Vision Rehabilitation.

Journal article Optom Vis Sci · June 2020 SIGNIFICANCE: Outpatient vision rehabilitation improves function in veterans with vision impairment, but the prevalence of cognitive impairment and the degree to which it may affect rehabilitation outcomes in the Veterans Affairs system are unknown. PURPOS ... Full text Link to item Cite

Two Approaches to Classifying and Quantifying Physical Resilience in Longitudinal Data.

Journal article J Gerontol A Biol Sci Med Sci · March 9, 2020 BACKGROUND: Approaches for quantifying physical resilience in older adults have not been described. METHODS: We apply two conceptual approaches to defining physical resilience to existing longitudinal data sets in which outcomes are measured after an acute ... Full text Link to item Cite

AGS and NIA Bench-to Bedside Conference Summary: Osteoporosis and Soft Tissue (Muscle and Fat) Disorders.

Journal article J Am Geriatr Soc · January 2020 This report summarizes the presentations and recommendations of the eleventh annual American Geriatrics Society and National Institute on Aging research conference, "Osteoporosis and Soft Tissue (Muscle/Fat) Disorders," on March 11-12, 2019, in Bethesda, M ... Full text Link to item Cite

Co-Prevalence of Alzheimer's Disease and Age-Related Macular Degeneration Established by Histopathologic Diagnosis.

Journal article J Alzheimers Dis · 2020 BACKGROUND: Previous epidemiologic studies have suggested an association between AMD and AD, and several therapeutic agents are being developed based on this principle. However, prior studies have provided conflicting results due in part to their reliance ... Full text Link to item Cite

Comorbid vision and cognitive impairments in older adults hospitalized for acute myocardial infarction.

Journal article J Comorb · 2020 Older patients presenting with acute myocardial infarction (AMI) often have comorbidities. Our objective was to examine how outcomes differ by cognitive and vision status in older AMI patients. We use data from a prospective cohort study conducted at 94 ho ... Full text Link to item Cite

Resiliency Groups Following Hip Fracture in Older Adults.

Journal article J Am Geriatr Soc · December 2019 OBJECTIVES: Defining common patterns of recovery after an acute health stressor (resiliency groups) has both clinical and research implications. We sought to identify groups of patients with similar recovery patterns across 10 outcomes following hip fractu ... Full text Link to item Cite

Resilience in Clinical Care: Getting a Grip on the Recovery Potential of Older Adults.

Journal article J Am Geriatr Soc · December 2019 BACKGROUND: Geriatricians are often confronted with unexpected health outcomes in older adults with complex multimorbidity. Aging researchers have recently called for a focus on physical resilience as a new approach to explaining such outcomes. Physical re ... Full text Link to item Cite

Assessing Feasibility of a Focused Geriatric Assessment in Older Adults with Sickle Cell Disease to Address Functional Risk Factors for Morbidity and Mortality

Journal article Blood · November 13, 2019 BackgroundDuring the last five decades the life expectancy for people living with sickle cell disease (SCD) has improved markedly, with median survival of 61 years in recent cohorts enrolle ... Full text Open Access Cite

Flow Cytometry Characterization of Cerebrospinal Fluid Monocytes in Patients With Postoperative Cognitive Dysfunction: A Pilot Study.

Journal article Anesth Analg · November 2019 Animal models suggest postoperative cognitive dysfunction may be caused by brain monocyte influx. To study this in humans, we developed a flow cytometry panel to profile cerebrospinal fluid (CSF) samples collected before and after major noncardiac surgery ... Full text Open Access Link to item Cite

Impact of Cognitive Impairment Across Specialties: Summary of a Report From the U13 Conference Series.

Journal article J Am Geriatr Soc · October 2019 Although declines in cognitive capacity are assumed to be a characteristic of aging, increasing evidence shows that it is age-related disease, rather than age itself, that causes cognitive impairment. Even so, older age is a primary risk factor for cogniti ... Full text Link to item Cite

Use of Functional Assessment to Define Therapeutic Goals and Treatment.

Journal article J Am Geriatr Soc · September 2019 This article summarizes the presentations and discussions from a workshop, "Using Functional Assessment to Define Therapeutic Goals and Treatment," which took place on November 30 to December 1, 2017. This workshop brought together transdisciplinary leader ... Full text Link to item Cite

Association of Sensory and Cognitive Impairment With Healthcare Utilization and Cost in Older Adults.

Journal article J Am Geriatr Soc · August 2019 OBJECTIVES: To examine the association between self-reported vision impairment (VI), hearing impairment (HI), and dual-sensory impairment (DSI), stratified by dementia status, on hospital admissions, hospice use, and healthcare costs. DESIGN: Retrospective ... Full text Link to item Cite

Ocular amyloid imaging at the crossroad of Alzheimer's disease and age-related macular degeneration: implications for diagnosis and therapy.

Journal article J Neurol · July 2019 Alzheimer's disease (AD) and age-related macular degeneration (AMD) are important disorders of aging, but significant challenges remain in diagnosis and therapy. Amyloid-beta (Aβ), found in the brain and a defining feature of AD, has also been observed in ... Full text Link to item Cite

Correction to: The AGING Initiative experience: a call for sustained support for team science networks.

Journal article Health Res Policy Syst · May 20, 2019 After publication of the original article [1], it came to the authors' attention that a funding source was omitted. This Correction article shows the updated Funding section. ... Full text Link to item Cite

Spectral-Domain OCT Measurements in Alzheimer's Disease: A Systematic Review and Meta-analysis.

Journal article Ophthalmology · April 2019 TOPIC: OCT is a noninvasive tool to measure specific retinal layers in the eye. The relationship of retinal spectral-domain (SD) OCT measurements with Alzheimer's disease (AD) and mild cognitive impairment (MCI) remains unclear. Hence, we conducted a syste ... Full text Link to item Cite

The INTUIT Study: Investigating Neuroinflammation Underlying Postoperative Cognitive Dysfunction.

Journal article J Am Geriatr Soc · April 2019 BACKGROUND/OBJECTIVES: Every year, up to 40% of the more than 16 million older Americans who undergo anesthesia/surgery develop postoperative cognitive dysfunction (POCD) or delirium. Each of these distinct syndromes is associated with decreased quality of ... Full text Open Access Link to item Cite

Eye and Vision Health for Tomorrow: From Recommendations to Coordinated Action.

Journal article JAMA Ophthalmol · February 1, 2019 In 2016, the report Making Eye Health a Population Health Imperative: Vision for Tomorrow was published by the National Academies of Sciences, Engineering, and Medicine. Conference presentations and key stakeholder discussions have continued the dialogue i ... Full text Link to item Cite

The 5Ts: Preliminary Development of a Framework to Support Inclusion of Older Adults in Research.

Journal article J Am Geriatr Soc · February 2019 BACKGROUND/OBJECTIVES: To address the underrepresentation of older adults in clinical research, the National Institutes of Health will require investigators to include individuals across the lifespan. As investigators from other fields endeavor to recruit ... Full text Link to item Cite

Memory and Confusion Complaints in Visually Impaired Older Adults: An Understudied Aspect of Well-Being.

Journal article Gerontol Geriatr Med · 2019 Objective: To determine the prevalence of cognitive (memory or confusion) complaints in older adults with visual impairment (VI). Method: We assessed the relationship between VI (corrected visual acuity [VA] < 20/40) and self-reported confusion or problems ... Full text Link to item Cite

Comorbidity of age-related macular degeneration with Alzheimer's disease: A histopathologic case-control study.

Journal article PLoS One · 2019 INTRODUCTION: Previous studies evaluating the association between clinically diagnosed Alzheimer's disease (AD) and age-related macular degeneration (AMD) have generated conflicting results. This study is the first to assess whether AMD prevalence is highe ... Full text Link to item Cite

American Geriatrics Society and National Institute on Aging Bench-to-Bedside Conference: Sensory Impairment and Cognitive Decline in Older Adults.

Journal article J Am Geriatr Soc · November 2018 This article summarizes the presentations and recommendations of the tenth annual American Geriatrics Society and National Institute on Aging Bench-to-Bedside research conference, "Sensory Impairment and Cognitive Decline," on October 2-3, 2017, in Bethesd ... Full text Link to item Cite

The AGING Initiative experience: a call for sustained support for team science networks.

Journal article Health Res Policy Syst · May 18, 2018 Team science, defined as collaborative research efforts that leverage the expertise of diverse disciplines, is recognised as a critical means to address complex healthcare challenges, but the practical implementation of team science can be difficult. Our o ... Full text Link to item Cite

Association of Integrated Care Coordination With Postsurgical Outcomes in High-Risk Older Adults: The Perioperative Optimization of Senior Health (POSH) Initiative.

Journal article JAMA Surg · May 1, 2018 IMPORTANCE: Older adults undergoing elective surgery experience higher rates of preventable postoperative complications than younger patients. OBJECTIVE: To assess clinical outcomes for older adults undergoing elective abdominal surgery via a collaborative ... Full text Link to item Cite

Language processing in age-related macular degeneration associated with unique functional connectivity signatures in the right hemisphere.

Journal article Neurobiol Aging · March 2018 Age-related macular degeneration (AMD) is a retinal disease associated with significant vision loss among older adults. Previous large-scale behavioral studies indicate that people with AMD are at increased risk of cognitive deficits in language processing ... Full text Open Access Link to item Cite

Evaluation of inner retinal layers as biomarkers in mild cognitive impairment to moderate Alzheimer's disease.

Journal article PLoS One · 2018 Inner retina in Alzheimer's Disease (AD) may experience neuroinflammation resulting in atrophy. The objective of our study was to determine whether retinal GCIPL (ganglion cell-inner plexiform layer) or nerve fiber layer (NFL) thickness may serve as noninv ... Full text Link to item Cite

Dual-Task Gait and Alzheimer's Disease Genetic Risk in Cognitively Normal Adults: A Pilot Study.

Journal article J Alzheimers Dis · 2018 BACKGROUND: Dual-task paradigms, in which an individual performs tasks separately and then concurrently, often demonstrate that people with neurodegenerative disorders experience more dual-task interference, defined as worse performance in the dual-task co ... Full text Link to item Cite

Relating Sensory, Cognitive, and Neural Factors to Older Persons' Perceptions about Happiness: An Exploratory Study.

Journal article J Aging Res · 2018 Despite increased rates of disease, disability, and social losses with aging, seniors consistently report higher levels of subjective well-being (SWB), a construct closely related to happiness, than younger adults. In this exploratory study, we utilized an ... Full text Open Access Link to item Cite

Trajectories of functional ability over the life course: a conceptual model of the interaction of stressor-induced functional loss and resilience.

Journal article Syst Dyn Rev · 2018 Understanding the factors that influence functional ability over the life course is integral to identifying clinical and public health policies to facilitate successful aging. The World Health Organization has advocated a conceptual framework to clarify th ... Full text Open Access Link to item Cite

Research Priorities to Advance the Health and Health Care of Older Adults with Multiple Chronic Conditions.

Journal article J Am Geriatr Soc · July 2017 OBJECTIVES: To prioritize research topics relevant to the care of the growing population of older adults with multiple chronic conditions (MCCs). DESIGN: Survey of experts in MCC practice, research, and policy. Topics were derived from white papers, fundin ... Full text Link to item Cite

Report: NIA Workshop on Measures of Physiologic Resiliencies in Human Aging.

Journal article J Gerontol A Biol Sci Med Sci · July 1, 2017 BACKGROUND/OBJECTIVES: Resilience, the ability to resist or recover from adverse effects of a stressor, is of widespread interest in social, psychologic, biologic, and medical research and particularly salient as the capacity to respond to stressors become ... Full text Link to item Cite

Frailty Assessment in Hospitalized Older Adults Using the Electronic Health Record.

Journal article Biol Res Nurs · March 2017 INTRODUCTION: Frailty, a clinical syndrome of decreased physiologic reserve and dysregulation in multiple physiologic systems, is associated with increased risk for adverse outcomes. PURPOSE: The aim of this retrospective, cross-sectional, correlational st ... Full text Link to item Cite

Maintenance and Representation of Mind Wandering during Resting-State fMRI.

Journal article Sci Rep · January 12, 2017 Major advances in resting-state functional magnetic resonance imaging (fMRI) techniques in the last two decades have provided a tool to better understand the functional organization of the brain both in health and illness. Despite such developments, charac ... Full text Open Access Link to item Cite

Wide-field retinal optical coherence tomography with wavefront sensorless adaptive optics for enhanced imaging of targeted regions.

Journal article Biomed Opt Express · January 1, 2017 The peripheral retina of the human eye offers a unique opportunity for assessment and monitoring of ocular diseases. We have developed a novel wide-field (>70°) optical coherence tomography system (WF-OCT) equipped with wavefront sensorless adaptive optics ... Full text Link to item Cite

Vitamin D insufficiency and cognitive impairment in Asians: a multi-ethnic population-based study and meta-analysis.

Journal article J Intern Med · September 2016 BACKGROUND: The relationship between vitamin D insufficiency and cognitive impairment remains equivocal in Asians. We examined the association between circulating 25-hydroxyvitamin D (25OHD) concentration and cognitive performance in a large multi-ethnic S ... Full text Link to item Cite

Identifying Patterns of Multimorbidity in Older Americans: Application of Latent Class Analysis.

Journal article J Am Geriatr Soc · August 2016 OBJECTIVES: To define multimorbidity "classes" empirically based on patterns of disease co-occurrence in older Americans and to examine how class membership predicts healthcare use. DESIGN: Retrospective cohort study. SETTING: Nationally representative sam ... Full text Link to item Cite

Physical frailty in late-life depression is associated with deficits in speed-dependent executive functions.

Journal article Int J Geriatr Psychiatry · May 2016 OBJECTIVE: The aim of this study was to examine the association between physical frailty and neurocognitive performance in late-life depression (LLD). METHODS: Cross-sectional design using baseline data from a treatment study of late-life depression was us ... Full text Link to item Cite

Physical Resilience in Older Adults: Systematic Review and Development of an Emerging Construct.

Journal article J Gerontol A Biol Sci Med Sci · April 2016 BACKGROUND: Resilience has been described in the psychosocial literature as the capacity to maintain or regain well-being during or after adversity. Physical resilience is a newer concept that is highly relevant to successful aging. Our objective was to ch ... Full text Link to item Cite

A Systematic Review of Conceptual Frameworks of Medical Complexity and New Model Development.

Journal article J Gen Intern Med · March 2016 BACKGROUND: Patient complexity is often operationalized by counting multiple chronic conditions (MCC) without considering contextual factors that can affect patient risk for adverse outcomes. OBJECTIVE: Our objective was to develop a conceptual model of co ... Full text Open Access Link to item Cite

Association of Co-Existing Impairments in Cognition and Self-Rated Vision and Hearing With Health Outcomes in Older Adults.

Journal article Gerontol Geriatr Med · 2016 OBJECTIVES: To assess the relationship of disability (activities of daily living (ADL) and instrumental ADL (IADL)), self-rated health (SRH), and 6-year mortality with co-existing impairments in vision (self-rated), hearing (self-rated) and/or cognition (S ... Full text Link to item Cite

Changes in Self-Rated Health During the Transition to Retiring Living Among Medicare Managed-Care Recipients.

Journal article J Hous Elderly · 2016 OBJECTIVES: Moving into a retirement community may be precipitated by or bring about changes in health status. We hypothesized that moving into a retirement community would be associated with a decline in self-rated health (SRH), but that health-related fa ... Full text Link to item Cite

Early and Long-term Outcomes of Older Adults after Acute Care Encounters for Chronic Obstructive Pulmonary Disease Exacerbation.

Journal article Ann Am Thorac Soc · December 2015 RATIONALE: Older patients are at high risk of death and rehospitalization after hospitalizations for acute exacerbations of chronic obstructive pulmonary disease (AE-COPD). Emergency department visits comprise a substantial portion of acute care encounters ... Full text Link to item Cite

Sex, Race, and Age Differences in Observed Years of Life, Healthy Life, and Able Life among Older Adults in The Cardiovascular Health Study.

Journal article J Pers Med · November 25, 2015 OBJECTIVE: Longevity fails to account for health and functional status during aging. We sought to quantify differences in years of total life, years of healthy life, and years of able life among groups defined by age, sex, and race. DESIGN: Primary analysi ... Full text Link to item Cite

Postoperative Cognitive Dysfunction: Minding the Gaps in Our Knowledge of a Common Postoperative Complication in the Elderly.

Journal article Anesthesiol Clin · September 2015 Postoperative cognitive dysfunction (POCD) is a common complication associated with significant morbidity and mortality in elderly patients. There is much interest in and controversy about POCD, reflected partly in the increasing number of articles publish ... Full text Link to item Cite

Phonemic fluency and brain connectivity in age-related macular degeneration: a pilot study.

Journal article Brain Connect · March 2015 Age-related macular degeneration (AMD), the leading cause of blindness in developed nations, has been associated with poor performance on tests of phonemic fluency. This pilot study sought to (1) characterize the relationship between phonemic fluency and r ... Full text Open Access Link to item Cite

Risk factors for cardiovascular disease across the spectrum of older age: the Cardiovascular Health Study.

Journal article Atherosclerosis · November 2014 OBJECTIVE: The associations of some risk factors with cardiovascular disease (CVD) are attenuated in older age; whereas others appear robust. The present study aimed to compare CVD risk factors across older age. METHODS: Participants (n = 4883) in the Card ... Full text Link to item Cite

Dyspnea and pain frequently co-occur among Medicare managed care recipients.

Journal article Ann Am Thorac Soc · July 2014 RATIONALE: Experimental and neuroimaging studies have suggested strong associations between dyspnea and pain. The co-occurrence of these symptoms has not been examined in community samples. OBJECTIVES: We sought to ascertain the co-occurrence of pain and d ... Full text Link to item Cite

Serum carboxymethyl-lysine, disability, and frailty in older persons: the Cardiovascular Health Study.

Journal article J Gerontol A Biol Sci Med Sci · June 2014 BACKGROUND: Advanced glycation endproducts are biologically active compounds that accumulate in disordered metabolism and normal aging. Carboxymethyl-lysine (CML), a ubiquitous human advanced glycation endproduct, has been associated with age-related condi ... Full text Link to item Cite

Comorbid visual and cognitive impairment: relationship with disability status and self-rated health among older Singaporeans.

Journal article Asia Pac J Public Health · May 2014 The objective of this study was to examine the prevalence and consequences of coexisting vision and cognitive impairments in an Asian population. Data were collected from 4508 community-dwelling Singaporeans aged 60 years and older. Cognition was assessed ... Full text Open Access Link to item Cite

Using the past to predict the future: latent class analysis of patterns of health service use of older adults in the emergency department.

Journal article J Am Geriatr Soc · April 2014 OBJECTIVES: To classify older adults in the emergency department (ED) according to healthcare use and to examine associations between group membership and future ED visits and hospital admissions. DESIGN: Secondary analysis. SETTING: Medicare Current Benef ... Full text Link to item Cite

Functional decline in older adults.

Journal article Am Fam Physician · September 15, 2013 Functional disability is common in older adults. It is often episodic and is associated with a high risk of subsequent health decline. The severity of disability is determined by physical impairments caused by underlying medical conditions, and by external ... Link to item Cite

A low-vision rehabilitation program for patients with mild cognitive deficits.

Journal article JAMA Ophthalmol · July 2013 IMPORTANCE: We are unaware of any standardized protocols within low-vision rehabilitation (LVR) to address cognitive impairment. OBJECTIVE: To design and pilot-test an LVR program for patients with macular disease and cognitive deficits. DESIGN: The Memory ... Full text Link to item Cite

Nondisease-specific problems and all-cause mortality in the REasons for Geographic and Racial Differences in Stroke study.

Journal article J Am Geriatr Soc · May 2013 OBJECTIVES: To evaluate the association between six nondisease-specific problems (problems that cross multiple domains of health) and mortality in middle-aged and older adults. DESIGN: Prospective, observational cohort. SETTING: U.S. population sample. PAR ... Full text Link to item Cite

Risk factors for hospital admission among older persons with newly diagnosed heart failure: findings from the Cardiovascular Health Study.

Journal article J Am Coll Cardiol · February 12, 2013 OBJECTIVES: This study sought to identify risk factors for the occurrence of all-cause hospital admissions among older persons after heart failure diagnosis, and to determine whether geriatric conditions would emerge as independent risk factors for admissi ... Full text Link to item Cite

Functional status after lung transplantation in older adults in the post-allocation score era.

Journal article Am J Transplant · January 2013 This manuscript describes the functional status trajectory of older (age 65 or older) and younger (age 18-64) adults after lung transplantation (LT). After the implementation of the lung allocation score (LAS) in 2005, older adults became the fastest growi ... Full text Link to item Cite

Memory deficit associated with worse functional trajectories in older adults in low-vision rehabilitation for macular disease.

Journal article J Am Geriatr Soc · November 2012 OBJECTIVES: To examine whether performance on a brief memory test is related to functional outcomes in older individuals undergoing low-vision rehabilitation (LVR) for macular disease. DESIGN: Observational cohort study of individuals receiving outpatient ... Full text Link to item Cite

Exploring predictors of complication in older surgical patients: a deficit accumulation index and the Braden Scale.

Journal article J Am Geriatr Soc · September 2012 OBJECTIVES: To determine whether readily collected perioperative information might identify older surgical patients at higher risk of complications. DESIGN: Retrospective cohort study. SETTING: Medical chart review at a single academic institution. PARTICI ... Full text Link to item Cite

Persistence and remission of musculoskeletal pain in community-dwelling older adults: results from the cardiovascular health study.

Journal article J Am Geriatr Soc · August 2012 OBJECTIVES: To characterize longitudinal patterns of musculoskeletal pain in a community sample of older adults over a 6-year period and to identify factors associated with persistence of pain. DESIGN: Secondary analysis of the Cardiovascular Health Study. ... Full text Link to item Cite

Higher medical morbidity burden is associated with external locus of control.

Journal article J Am Geriatr Soc · April 2012 OBJECTIVES: To describe the association between an increasing number of coexisting conditions and locus of control (LOC), a psychological construct reflecting the degree to which one perceives circumstances to be controlled by personal actions (internal LO ... Full text Link to item Cite

The Junior Faculty Laboratory: an innovative model of peer mentoring.

Journal article Acad Med · December 2011 Mentoring in academic medicine has been shown to contribute to the success of junior faculty, resulting in increased productivity, career satisfaction, and opportunities for networking. Although traditional dyadic mentoring, involving one senior faculty me ... Full text Link to item Cite

Categorizing the effect of comorbidity: a qualitative study of individuals' experiences in a low-vision rehabilitation program.

Journal article J Am Geriatr Soc · October 2011 OBJECTIVES: To identify generalizable ways that comorbidity affects older adults' experiences in a health service program directed toward an index condition and to develop a framework to assist clinicians in approaching comorbidity in the design, delivery, ... Full text Link to item Cite

Black-white disparity in disability: the role of medical conditions.

Journal article J Am Geriatr Soc · May 2011 OBJECTIVES: To describe the independent contributions of selected medical conditions to the disparity between black and white people in disability rates, controlling for demographic and socioeconomic factors. DESIGN: Cross-sectional analysis of a community ... Full text Link to item Cite

Patterns and predictors of recovery from exhaustion in older adults: the cardiovascular health study.

Journal article J Am Geriatr Soc · February 2011 OBJECTIVES: To estimate the likelihood of, and factors associated with, recovery from exhaustion in older adults. DESIGN: Secondary analysis of a cohort study. SETTING: Six annual examinations in four U.S. communities. PARTICIPANTS: Four thousand five hund ... Full text Link to item Cite

Comorbid cognitive impairment and functional trajectories in low vision rehabilitation for macular disease.

Journal article Aging Clin Exp Res · 2011 BACKGROUND AND AIMS: Comorbid cognitive impairment is common among visually impaired older adults. This study investigated whether baseline cognitive status predicts functional trajectories among older adults in low vision rehabilitation (LVR) for macular ... Full text Link to item Cite

Chronic medical conditions and the sex-based disparity in disability: the Cardiovascular Health Study.

Journal article J Gerontol A Biol Sci Med Sci · December 2010 BACKGROUND: Older women experience disability more commonly than their male peers. This disparity may be due, in part, to sex-based differences in the prevalence or the disabling effects of common medical conditions. The objectives of this analysis were to ... Full text Link to item Cite

Accuracy of self-reported height and weight in a community-based sample of older African Americans and whites.

Journal article J Gerontol A Biol Sci Med Sci · October 2010 BACKGROUND: To ascertain accuracy of self-reported height, weight (and hence body mass index) in African American and white women and men older than 70 years of age. METHOD: The sample consisted of cognitively intact participants at the third in-person wav ... Full text Link to item Cite

Parkinson's disease in women: a call for improved clinical studies and for comparative effectiveness research.

Journal article Maturitas · April 2010 The incidence and prevalence of Parkinson's disease (PD) is expected to rise precipitously over the next several decades, as will the associated healthcare related costs. The epidemiology and disease manifestations of PD may differ when comparing women to ... Full text Link to item Cite

Medication prescribing practices for older prisoners in the Texas prison system.

Journal article Am J Public Health · April 2010 OBJECTIVES: We sought to assess appropriateness of medication prescribing for older Texas prisoners. METHODS: In this 12-month cross-sectional study of 13 117 prisoners (aged > or = 55 years), we assessed medication use with Zhan criteria and compared our ... Full text Link to item Cite

Prevalence and patterns of comorbid cognitive impairment in low vision rehabilitation for macular disease.

Journal article Arch Gerontol Geriatr · 2010 The prevalence of comorbid cognitive impairment among older adults referred to low vision rehabilitation (LVR) for macular disease is unknown. We performed cognitive testing on 101 adults aged 65 years or older with macular disease who were referred to The ... Full text Link to item Cite

Emergency department discharge diagnosis and adverse health outcomes in older adults.

Journal article J Am Geriatr Soc · October 2009 OBJECTIVES: To determine the relationship between the reason for an emergency department (ED) visit and subsequent risk of adverse health outcomes in older adults discharged from the ED. DESIGN: Secondary analysis of data from the Medicare Current Benefici ... Full text Link to item Cite

Correlation between symptoms and function in older adults with comorbidity.

Journal article J Am Geriatr Soc · April 2009 OBJECTIVES: To describe the relationship between symptom scores and mobility function measures, assess whether symptom scores and disease scores are similarly associated with mobility function, and identify clusters of symptoms that are most strongly assoc ... Full text Link to item Cite

Comorbidities and the Gender Difference in Disability: Analysis of the Cardiovascular Health Study

Journal article JOURNAL OF THE AMERICAN GERIATRICS SOCIETY · March 1, 2009 Link to item Cite

Medication Prescribing Practices for Geriatric Prisoners in the Largest State Prison System

Journal article JOURNAL OF THE AMERICAN GERIATRICS SOCIETY · March 1, 2009 Link to item Cite

Depressive symptomatology and fracture risk in community-dwelling older men and women.

Journal article Aging Clin Exp Res · December 2008 BACKGROUND AND AIMS: Previous studies suggest that depression increases risk of falls, low bone mineral density, and fractures. Our aim was to evaluate whether depressive symptomatology alone predicts 5- year clinical fracture risk in older adults. METHODS ... Full text Link to item Cite

New light on an age-old issue.

Journal article Mech Ageing Dev · November 2008 In this issue, Varadhan and colleagues propose a methodologic framework that seeks to quantify impaired resiliency in dynamic systems underlying the frailty syndrome. We view this work, which is based on modeling stimulus-response data, as an exciting expa ... Full text Link to item Cite

Frailty and its potential relevance to cardiovascular care.

Journal article Mayo Clin Proc · October 2008 Frailty is characterized by vulnerability to acute stressors and is a consequence of decline in overall function and physiologic reserves. An estimated 7% of the US population older than 65 years and 30% of octogenarians are frail. The domains to define fr ... Full text Link to item Cite

Frailty predicts some but not all adverse outcomes in older adults discharged from the emergency department.

Journal article J Am Geriatr Soc · September 2008 OBJECTIVES: To determine whether frail older adults, based on a deficit accumulation index (DAI), are at greater risk of adverse outcomes after discharge from the emergency department (ED). DESIGN AND SETTING: Secondary analysis of data from the Medicare C ... Full text Link to item Cite

A quality improvement program to enhance after-hours telephone communication between nurses and physicians in a long-term care facility.

Journal article J Am Geriatr Soc · June 2008 OBJECTIVES: To determine whether satisfaction of on-site nurses with after-hours telephone communication with off-site physicians improved in one long-term care (LTC) facility after a nurse-oriented intervention. DESIGN: Longitudinal quality improvement st ... Full text Link to item Cite

After-hours calls from long-term care facilities in a geriatric medicine training program.

Journal article J Am Geriatr Soc · December 2007 OBJECTIVES: To describe after-hours telephone calls from nurses in long-term care (LTC) facilities to doctors in a geriatric medicine training program. DESIGN: Evaluation of 1,928 after-hours calls from LTC facilities over a 10-month period in 2005/06. SET ... Full text Link to item Cite

A possible role of recurrent major depression in risk of fracture - Reply[7]

Journal article Archives of Internal Medicine · November 26, 2007 Full text Cite

Frailty thy name is ... Phrailty?

Journal article J Gerontol A Biol Sci Med Sci · July 2007 Full text Link to item Cite

The combined effect of visual impairment and cognitive impairment on disability in older people.

Journal article J Am Geriatr Soc · June 2007 OBJECTIVES: To determine the risk of disability in individuals with coexisting visual and cognitive impairment and to compare the magnitude of risk associated with visual impairment, cognitive impairment, or the multimorbidity. DESIGN: Prospective cohort. ... Full text Link to item Cite

Smoking cessation in older adults: A review

Journal article Geriatrics and Aging · June 1, 2007 Smoking is the leading cause of preventable death worldwide. Though older adults are the segment of the population least likely to smoke, they incur significant morbidity and mortality from tobacco use and can benefit from quitting. Older smokers have beli ... Cite

Development and implementation of the TrAC (Tracking After-hours Calls) database: a tool to collect longitudinal data on after-hours telephone calls in long-term care.

Journal article J Am Med Dir Assoc · March 2007 INTRODUCTION: Effective telephone communication between long-term care (LTC) nurses and physicians is an integral part of high-quality care, yet little is known about this key aspect of LTC practice. The authors describe the development and implementation ... Full text Link to item Cite

Effect of selective serotonin reuptake inhibitors on the risk of fracture.

Journal article Arch Intern Med · January 22, 2007 BACKGROUND: Depression and osteoporotic fractures are common ailments among elderly persons. Selective serotonin reuptake inhibitors (SSRIs) are frequently used in the treatment of depression in this population, and the association between daily SSRI use a ... Full text Link to item Cite

Severe hypocalcemia following bisphosphonate treatment in a patient with Paget's disease of bone.

Journal article Bone · October 2006 Bisphosphonate therapy is a common and effective treatment for Paget's disease of bone, osteoporosis, hypercalcemia of malignancy and cancer metastatic to bone. Clinically significant hypocalcemia has not been reported in patients with Paget's disease of b ... Full text Link to item Cite

Inter-disciplinary focus groups on telephone medicine: a quality improvement initiative.

Journal article J Am Med Dir Assoc · September 2006 OBJECTIVE: To identify opportunities for quality improvement in long-term care telephone medicine using a model of interdisciplinary focus groups. DESIGN: Descriptive pilot project. SETTING: Extended Care and Rehabilitation Center (ECRC), Durham VA Medical ... Full text Link to item Cite

Adding injury to insult: fracture risk after stroke in veterans.

Journal article J Am Geriatr Soc · July 2006 OBJECTIVES: To determine fracture risk in U.S. stroke patients and identify patient characteristics that predict highest fracture risk in two complementary cohorts. DESIGN: Secondary analyses of two prospective cohorts. SETTING: Veterans Affairs (VA) Medic ... Full text Link to item Cite

Patterns and predictors of smoking cessation in an elderly cohort.

Journal article J Am Geriatr Soc · March 2006 OBJECTIVES: To identify subject characteristics that predict smoking cessation and describe patterns of cessation and recidivism in a cohort of elderly smokers. DESIGN: Prospective cohort study. SETTING: Piedmont region, North Carolina. PARTICIPANTS: Five ... Full text Link to item Cite

Uncoupling of bone turnover following hip replacement.

Journal article Calcif Tissue Int · July 2002 Studies using total hip replacement surgery as a model for acute hip injury have shown that bone mineral density of the proximal femur decreases 6-18% in the 6 months following surgery. To examine the acute biochemical mechanism associated with bone loss, ... Full text Link to item Cite