Heberto Suarez Roca | Scholars@Duke

Heberto Suarez Roca
Research Scientist

My primary research interest has been focused on the involvement of stress and emotions in the perception of pain and the development of painful chronic syndromes. Also, I have been interested in the search for organic compounds and natural products with analgesic and anti-inflammatory properties.

Background - Education, Training, & Certifications

M.B.B.S., University of Zulia, Maracaibo 1983
Ph.D., University of North Carolina, Chapel Hill 1991
M.D., University of Zulia, Maracaibo 2001

Current Research Interests

My current interest is on the interactions between the cardiovascular and sensory systems, specifically, the role of baroreflex function, which regulates blood pressure, on postoperative acute and chronic pain and inflammation.

Current Appointments & Affiliations

Research Scientist, Anesthesiology, Clinical Science Departments

Contact Information

6124 Medical Science Research Bldg. III, 3 Genome Court, Durham, NC 27705
heberto.suarez.roca@duke.edu +1 919 681 5688
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Expertise
Subject Headings
Global Scholarship
- Expertise
  - Venezuela (Bolivarian Republic of) (Country)
- Research
  - Venezuela (Bolivarian Republic of) (Country)
- Teaching
  - Venezuela (Bolivarian Republic of) (Country)
Research
Selected Grants
- Role of Preoperative Baroreflex Sensitivity on Postoperative and Persistent Pain after Thoracic Surgery awarded by National Institutes of Health 2019 - 2021
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Suarez-Roca, Heberto, Rebecca Y. Klinger, Mihai V. Podgoreanu, Ru-Rong Ji, Martin I. Sigurdsson, Nathan Waldron, Joseph P. Mathew, and William Maixner. “Contribution of Baroreceptor Function to Pain Perception and Perioperative Outcomes..” Anesthesiology 130, no. 4 (April 2019): 634–50. https://doi.org/10.1097/ALN.0000000000002510.
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  - Chacin-Fernández, Josymar, Margarita Chacin Fuenmayor, Lorena Piñerua-Shuhaibar, and Heberto Suarez-Roca. “Psychological intervention based on psychoneuroimmunology improves clinical evolution, quality of life, and immunity of children with leukemia: A preliminary study..” Health Psychology Open 6, no. 1 (January 2019). https://doi.org/10.1177/2055102919838902.
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  - Osorio, M. A. M., S. A. K. Shulz, J. M. M. Mejia, and H. Suarez-Roca. “Impact of two therapeutic interventions in patients with non-specific low back pain.” Salud Uninorte 34, no. 2 (May 1, 2018): 338–48. https://doi.org/10.14482/sun.34.2.612.88.
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  - Rada, M., R. Cárdenas-Fernández, C. Guevara, A. C. Fernández, and H. Suárez-Roca. “Magnesium sulfate prevents the development of forced swim induced hyperalgesia in rats.” Investigacion Clinica (Venezuela) 59, no. 1 (January 1, 2018): 5–16. https://doi.org/10.22209/ICv.59n1a01.
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  - Ferrer-Mavárez, Rosa Elena, Noribel Coromoto Urdaneta-Gutierrez, Nicole Porta-Knabenschuh, Lucía Chiquinquirá Rodríguez-Villasmil, Cecire Carolina Rosales-Peña, Gustavo Adolfo Espinoza, Ligia Biagina Angel-Migliore, et al. “[Novel central dopaminergic agents derived from atypical di-substituted 2-aminoindane-4, 7. Synthesis and central pharmacological profile]..” Investigacion Clinica 56, no. 2 (June 2015): 137–54.
  - Guevara, Coram, Ana Cristina Fernandez, Ricardo Cardenas, and Heberto Suarez-Roca. “Reduction of spinal PGE2 concentrations prevents swim stress-induced thermal hyperalgesia..” Neuroscience Letters 591 (March 2015): 110–14. https://doi.org/10.1016/j.neulet.2015.02.035.
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  - Suarez-Roca, H., L. Quintero, R. Avila, S. Medina, M. De Freitas, and R. Cárdenas. “Central immune overactivation in the presence of reduced plasma corticosterone contributes to swim stress-induced hyperalgesia..” Brain Research Bulletin 100 (January 2014): 61–69. https://doi.org/10.1016/j.brainresbull.2013.11.003.
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  - Angel Guio, J. E., A. Santiago, R. Rossi, B. Migliore de Angel, S. Barolo, S. Andujar, V. Hernandez, et al. “Synthesis and preliminary pharmacological evaluation of methoxilated indoles with possible dopaminergic central action.” Latin American Journal of Pharmacy 30, no. 10 (December 1, 2011).
  - Quintero, Luis, Ricardo Cardenas, and Heberto Suarez-Roca. “Stress-induced hyperalgesia is associated with a reduced and delayed GABA inhibitory control that enhances post-synaptic NMDA receptor activation in the spinal cord..” Pain 152, no. 8 (August 2011): 1909–22. https://doi.org/10.1016/j.pain.2011.04.017.
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  - Piñerua-Shuhaibar, Lorena, Nereida Villalobos, Nerio Delgado, Maria Angelina Rubio, and Heberto Suarez-Roca. “Enhanced central thermal nociception in mildly depressed nonpatients and transiently sad healthy subjects..” The Journal of Pain : Official Journal of the American Pain Society 12, no. 3 (March 2011): 360–69. https://doi.org/10.1016/j.jpain.2010.08.002.
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  - Mora, Marylú, Luis Quintero, Ricardo Cardenas, Heberto Suárez-Roca, María Zavala, and Nola Montiel. “[Association between HSV-2 infection and serum anti-rat brain antibodies in patients with autism]..” Investigacion Clinica 50, no. 3 (September 2009): 315–26.
  - Urdaneta, A., A. Siso, B. Urdaneta, R. Cardenas, L. Quintero, R. Avila, and H. Suarez-Roca. “Lack of correlation between the central anti-nociceptive and peripheral anti-inflammatory effects of selective COX-2 inhibitor parecoxib..” Brain Research Bulletin 80, no. 1–2 (August 2009): 56–61. https://doi.org/10.1016/j.brainresbull.2009.05.009.
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  - Suarez-Roca, Heberto, Lorena Leal, José Antonio Silva, Lorena Pinerua-Shuhaibar, and Luis Quintero. “Reduced GABA neurotransmission underlies hyperalgesia induced by repeated forced swimming stress..” Behavioural Brain Research 189, no. 1 (May 2008): 159–69. https://doi.org/10.1016/j.bbr.2007.12.022.
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  - Andujar, Sebastian A., Biagina Migliore de Angel, Jaime E. Charris, Anita Israel, Heberto Suárez-Roca, Simon E. López, Maria R. Garrido, et al. “Synthesis, dopaminergic profile, and molecular dynamics calculations of N-aralkyl substituted 2-aminoindans..” Bioorganic & Medicinal Chemistry 16, no. 6 (March 2008): 3233–44. https://doi.org/10.1016/j.bmc.2007.12.027.
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  - Piñerúa-Shuhaibar, Lorena, Jesús Estévez, and Heberto Suárez-Roca. “[The Zung's autoscale for depression as predictor of sensorial and autonomic alterations to pain]..” Investigacion Clinica 48, no. 4 (December 2007): 469–83.
  - Avila-Peña, D., N. Peña, L. Quintero, and H. Suárez-Roca. “Antinociceptive activity of Syzygium jambos leaves extract on rats..” Journal of Ethnopharmacology 112, no. 2 (June 2007): 380–85. https://doi.org/10.1016/j.jep.2007.03.027.
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  - Suarez-Roca, Heberto, Luis Quintero, Jose Luis Arcaya, William Maixner, and Srinivas G. Rao. “Stress-induced muscle and cutaneous hyperalgesia: differential effect of milnacipran..” Physiology & Behavior 88, no. 1–2 (June 2006): 82–87. https://doi.org/10.1016/j.physbeh.2006.03.010.
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  - Suarez-Roca, Heberto, Jose Antonio Silva, Jose Luis Arcaya, Luis Quintero, William Maixner, and Lorena Pinerua-Shuhaibar. “Role of mu-opioid and NMDA receptors in the development and maintenance of repeated swim stress-induced thermal hyperalgesia..” Behavioural Brain Research 167, no. 2 (February 2006): 205–11. https://doi.org/10.1016/j.bbr.2005.09.006.
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  - Uzcátegui, Bercy, Dinorah Avila, Heberto Suárez-Roca, Luis Quintero, José Ortega, and Beatriz González. “Anti-inflammatory, antinociceptive, and antipyretic effects of Lantana trifolia Linnaeus in experimental animals..” Investigacion Clinica 45, no. 4 (December 2004): 317–22.
  - Rodríguez, L. J., Y. Medina, H. Suárez-Roca, B. M. De Angel, A. Israel, J. E. Charris, S. E. López, J. A. Caldera, and J. E. Angel-Guio. “Conformational theoretical study of substituted and non-substituted N-aralkyl-2-aminoindans and its relation with dopaminergic activity.” Journal of Molecular Structure: Theochem 636, no. 1–3 (September 30, 2003): 1–8. https://doi.org/10.1016/S0166-1280(03)00023-X.
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  - Suarez-Roca, H., L. Piñerua-Shuhaibar, M. E. Morales, and W. Maixner. “Increased perception of post-ischemic paresthesias in depressed subjects..” J Psychosom Res 55, no. 3 (September 2003): 253–57. https://doi.org/10.1016/s0022-3999(02)00498-1.
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  - Quintero, Luis, Maria Cecilia Cuesta, Jose Antonio Silva, Jose Luis Arcaya, Lorena Pinerua-Suhaibar, William Maixner, and Heberto Suarez-Roca. “Repeated swim stress increases pain-induced expression of c-Fos in the rat lumbar cord..” Brain Res 965, no. 1–2 (March 7, 2003): 259–68. https://doi.org/10.1016/s0006-8993(02)04224-5.
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  - Suarez-Roca, Heberto, and Luigi X. Cubeddu. “The selective serotonin reuptake inhibitor citalopram induces the storage of serotonin in catecholaminergic terminals..” The Journal of Pharmacology and Experimental Therapeutics 302, no. 1 (July 2002): 174–79. https://doi.org/10.1124/jpet.302.1.174.
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  - Cuesta, M. C., L. Quintero, H. Pons, and H. Suarez-Roca. “Substance P and calcitonin gene-related peptide increase IL-1 beta, IL-6 and TNF alpha secretion from human peripheral blood mononuclear cells..” Neurochemistry International 40, no. 4 (April 2002): 301–6. https://doi.org/10.1016/s0197-0186(01)00094-8.
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  - Quintero, L., M. Moreno, C. Avila, J. Arcaya, W. Maixner, and H. Suarez-Roca. “Long-lasting delayed hyperalgesia after subchronic swim stress..” Pharmacol Biochem Behav 67, no. 3 (November 2000): 449–58. https://doi.org/10.1016/s0091-3057(00)00374-9.
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  - González, B., H. Suárez-Roca, A. Bravo, R. Salas-Auvert, and D. Avila. “Chemical composition and biological activity of extracts from arrabidaea bilabiata..” Pharmaceutical Biology 38, no. 4 (January 2000): 287–90. https://doi.org/10.1076/1388-0209(200009)3841-aft287.
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  - Cuesta, M. C., J. L. Arcaya, G. Cano, L. Sanchez, W. Maixner, and H. Suarez-Roca. “Opposite modulation of capsaicin-evoked substance P release by glutamate receptors..” Neurochem Int 35, no. 6 (December 1999): 471–78. https://doi.org/10.1016/s0197-0186(99)00081-9.
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  - Piñerua-Shuhaibar, L., D. Prieto-Rincon, A. Ferrer, E. Bonilla, W. Maixner, and H. Suarez-Roca. “Reduced tolerance and cardiovascular response to ischemic pain in minor depression..” J Affect Disord 56, no. 2–3 (December 1999): 119–26. https://doi.org/10.1016/s0165-0327(99)00051-8.
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  - Cano, G., J. L. Arcaya, G. Gómez, W. Maixner, and H. Suarez-Roca. “Multiphasic morphine modulation of substance P release from capsaicin-sensitive primary afferent fibers..” Neurochem Res 24, no. 10 (October 1999): 1203–7. https://doi.org/10.1023/a:1020963120333.
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  - Arcaya, J. L., G. Cano, G. Gómez, W. Maixner, and H. Suárez-Roca. “Dynorphin A increases substance P release from trigeminal primary afferent C-fibers..” Eur J Pharmacol 366, no. 1 (January 29, 1999): 27–34. https://doi.org/10.1016/s0014-2999(98)00897-8.
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  - Cano, G., H. Suárez-Roca, and E. Bonilla. “Alterations of excitatory amino acid receptors in the brain of manganese-treated mice..” Molecular and Chemical Neuropathology 30, no. 1–2 (January 1997): 41–52. https://doi.org/10.1007/bf02815149.
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  - Carrizo, E., G. Cano, H. Suarez-Roca, and E. Bonilla. “Motor activity and quantitative autoradiographic analysis of muscarinic receptors in the brain of rats subjected to the forced swimming test..” Brain Research Bulletin 42, no. 2 (January 1997): 133–39. https://doi.org/10.1016/s0361-9230(96)00226-2.
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  - Cano, G., H. Suárez-Roca, and E. Bonilla. “Manganese poisoning reduces strychnine-insensitive glycine binding sites in the globus pallidus of the mouse brain..” Investigacion Clinica 37, no. 4 (December 1996): 209–19.
  - Suarez-Roca, H., and W. Maixner. “Morphine produces a biphasic modulation of substance P release from cultured dorsal root ganglion neurons..” Neurosci Lett 194, no. 1–2 (July 14, 1995): 41–44. https://doi.org/10.1016/0304-3940(95)11721-8.
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  - Cuesta de Di Zio, M. C., G. Gómez, E. Bonilla, and H. Suarez-Roca. “Autoreceptor presynaptic control of dopamine release from striatum is lost at early stages of manganese poisoning..” Life Sciences 56, no. 22 (January 1995): 1857–64. https://doi.org/10.1016/0024-3205(95)00160-8.
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  - Suarez-Roca, H., and W. Maixner. “Activation of kappa opioid receptors by U50488H and morphine enhances the release of substance P from rat trigeminal nucleus slices..” J Pharmacol Exp Ther 264, no. 2 (February 1993): 648–53.
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  - Suarez-Roca, H., and W. Maixner. “Delta-opioid-receptor activation by [D-Pen2,D-Pen5]enkephalin and morphine inhibits substance P release from trigeminal nucleus slices..” Eur J Pharmacol 229, no. 1 (December 8, 1992): 1–7. https://doi.org/10.1016/0014-2999(92)90278-c.
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  - Suarez-Roca, H., L. Abdullah, J. Zuniga, S. Madison, and W. Maixner. “Multiphasic effect of morphine on the release of substance P from rat trigeminal nucleus slices..” Brain Res 579, no. 2 (May 8, 1992): 187–94. https://doi.org/10.1016/0006-8993(92)90050-j.
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  - Suarez-Roca, H., and W. Maixner. “Morphine produces a multiphasic effect on the release of substance P from rat trigeminal nucleus slices by activating different opioid receptor subtypes..” Brain Res 579, no. 2 (May 8, 1992): 195–203. https://doi.org/10.1016/0006-8993(92)90051-a.
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  - Madison, S., E. A. Whitsel, H. Suarez-Roca, and W. Maixner. “Sensitizing effects of leukotriene B4 on intradental primary afferents..” Pain 49, no. 1 (April 1992): 99–104. https://doi.org/10.1016/0304-3959(92)90194-g.
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  - Castro-Caraballo, F., H. Suárez-Roca, J. Estévez, and E. Bonilla. “[Spontaneous motor activity in mice overloaded with iron-dextran]..” Investigacion Clinica 33, no. 3 (January 1992): 121–34.
  - Morales, L. M., J. Estévez, H. Suárez, R. Villalobos, L. Chacín de Bonilla, and E. Bonilla. “Nutritional evaluation of Huntington disease patients..” Am J Clin Nutr 50, no. 1 (July 1989): 145–50. https://doi.org/10.1093/ajcn/50.1.145.
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  - Suarez-Roca, H., T. Lovenberg, and L. X. Cubeddu. “Comparative dopamine-cholinergic mechanisms in the olfactory tubercle and the striatum: effects of metoclopramide..” The Journal of Pharmacology and Experimental Therapeutics 243, no. 3 (December 1987): 840–51.
  - “Addicted to Compulsions: A Complex Case Study of Obsessive and Compulsive Disorder Treated with Acceptance and Commitment Therapy (ACT) and Exposure Therapy (ERP).” Drug Dependence and Addiction Open Access Journal, n.d., 01–08. https://doi.org/10.33513/ddad/1801-01.
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- Book Sections
  - Suarez Roca, H. “Opposite opioid modulation of SP-containing primary afferents.” In New Advances in Cardiovascular Physiology and Pharmacology. Excerpta Médica International, Congress Series. Elservier Science Publisher, 1998.
- Conference Papers
  - Heurich, Rainer, Tamara King, Frank Porreca, Heberto Suarez-Roca, and Srinivas Rao. “Analgesic efficacy of milnacipran in animal models of chronic pain.” In Biological Psychiatry, 63:64S-64S. ELSEVIER SCIENCE INC, 2008.
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  - Suarez-Roca, H., and W. Maixner. “Opposite opioid modulation of substance P-containing primary afferents.” In New Advances in Cardiovascular Physiology and Pharmacology, edited by M. Velasco and R. Hernandez, 1184:201–16. ELSEVIER SCIENCE BV, 1998.
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Subject Headings

Global Scholarship

Expertise

Research

Teaching

Selected Grants

Selected Publications

Academic Articles

Book Sections

Conference Papers