Heberto Suarez Roca
Research Scientist
My primary research interest has been focused on the involvement of stress and emotions in the perception of pain and the development of painful chronic syndromes. Also, I have been interested in the search for organic compounds and natural products with analgesic and anti-inflammatory properties.
Background - Education, Training, & Certifications
- M.B.B.S., University of Zulia, Maracaibo 1983
- Ph.D., University of North Carolina, Chapel Hill 1991
- M.D., University of Zulia, Maracaibo 2001
Current Research Interests
My current interest is on the interactions between the cardiovascular and sensory systems, specifically, the role of baroreflex function, which regulates blood pressure, on postoperative acute and chronic pain and inflammation.
Current Appointments & Affiliations
- Research Scientist, Anesthesiology, Clinical Science Departments
Contact Information
- 2036 Snyderman Bldg, Durham, NC 27705
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heberto.suarez.roca@duke.edu
+1 919 681 5688
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Research Gate
- Expertise
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Subject Headings
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Global Scholarship
- Publications & Artistic Works
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Selected Publications
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Academic Articles
- Suarez-Roca, H, Klinger, RY, Podgoreanu, MV, Ji, R-R, Sigurdsson, MI, Waldron, N, Mathew, JP, and Maixner, W. "Contribution of Baroreceptor Function to Pain Perception and Perioperative Outcomes." Anesthesiology 130, no. 4 (April 2019): 634-650. Full Text
- Osorio, MAM, Shulz, SAK, Mejia, JMM, and Suarez-Roca, H. "Impact of two therapeutic interventions in patients with non-specific low back pain." Salud Uninorte 34, no. 2 (May 1, 2018): 338-348. Full Text
- Rada, M, Cárdenas-Fernández, R, Guevara, C, Fernández, AC, and Suárez-Roca, H. "Magnesium sulfate prevents the development of forced swim induced hyperalgesia in rats." Investigacion Clinica (Venezuela) 59, no. 1 (January 1, 2018): 5-16. Full Text
- Ferrer-Mavárez, RE, Urdaneta-Gutierrez, NC, Porta-Knabenschuh, N, Rodríguez-Villasmil, LC, Rosales-Peña, CC, Espinoza, GA, Angel-Migliore, LB, Balza-Jiménez, KDC, Perdomo-Zavarce, LE, Faría-Quintero, AR, Dabian-Makarem, AS, Zapata-Cárdenas, MV, Linero-Arrieta, AR, Acurero-Castellano, GA, Israel-Stern, A, Rosario Garrido, M, Suárez-Roca, H, Migliore de Angel, BDC, Lopez-D'Sola, SE, Charris-Charris, J, Ramírez-Moran, MM, and Angel-Guío, JE. "[Novel central dopaminergic agents derived from atypical di-substituted 2-aminoindane-4, 7. Synthesis and central pharmacological profile]." Investigacion Clinica 56, no. 2 (June 2015): 137-154.
- Guevara, C, Fernandez, AC, Cardenas, R, and Suarez-Roca, H. "Reduction of spinal PGE2 concentrations prevents swim stress-induced thermal hyperalgesia." Neuroscience Letters 591 (March 2015): 110-114. Full Text
- Suarez-Roca, H, Quintero, L, Avila, R, Medina, S, De Freitas, M, and Cárdenas, R. "Central immune overactivation in the presence of reduced plasma corticosterone contributes to swim stress-induced hyperalgesia." Brain Research Bulletin 100 (January 2014): 61-69. Full Text
- Angel Guio, JE, Santiago, A, Rossi, R, Migliore de Angel, B, Barolo, S, Andujar, S, Hernandez, V, Rosales, C, Charris, JE, Suarez-Roca, H, Israel, A, Ramirez, MM, Ortega, J, Cano, NH, and Enriz, RD. "Synthesis and preliminary pharmacological evaluation of methoxilated indoles with possible dopaminergic central action." Latin American Journal of Pharmacy 30, no. 10 (December 1, 2011): 1934-null.
- Quintero, L, Cardenas, R, and Suarez-Roca, H. "Stress-induced hyperalgesia is associated with a reduced and delayed GABA inhibitory control that enhances post-synaptic NMDA receptor activation in the spinal cord." Pain 152, no. 8 (August 2011): 1909-1922. Full Text
- Piñerua-Shuhaibar, L, Villalobos, N, Delgado, N, Rubio, MA, and Suarez-Roca, H. "Enhanced central thermal nociception in mildly depressed nonpatients and transiently sad healthy subjects." The Journal of Pain : Official Journal of the American Pain Society 12, no. 3 (March 2011): 360-369. Full Text
- Mora, M, Quintero, L, Cardenas, R, Suárez-Roca, H, Zavala, M, and Montiel, N. "[Association between HSV-2 infection and serum anti-rat brain antibodies in patients with autism]." Investigacion Clinica 50, no. 3 (September 2009): 315-326.
- Urdaneta, A, Siso, A, Urdaneta, B, Cardenas, R, Quintero, L, Avila, R, and Suarez-Roca, H. "Lack of correlation between the central anti-nociceptive and peripheral anti-inflammatory effects of selective COX-2 inhibitor parecoxib." Brain Research Bulletin 80, no. 1-2 (August 2009): 56-61. Full Text
- Suarez-Roca, H, Leal, L, Silva, JA, Pinerua-Shuhaibar, L, and Quintero, L. "Reduced GABA neurotransmission underlies hyperalgesia induced by repeated forced swimming stress." Behavioural Brain Research 189, no. 1 (May 2008): 159-169. Full Text
- Andujar, SA, de Angel, BM, Charris, JE, Israel, A, Suárez-Roca, H, López, SE, Garrido, MR, Cabrera, EV, Visbal, G, Rosales, C, Suvire, FD, Enriz, RD, and Angel-Guío, JE. "Synthesis, dopaminergic profile, and molecular dynamics calculations of N-aralkyl substituted 2-aminoindans." Bioorganic & Medicinal Chemistry 16, no. 6 (March 2008): 3233-3244. Full Text
- Piñerúa-Shuhaibar, L, Estévez, J, and Suárez-Roca, H. "[The Zung's autoscale for depression as predictor of sensorial and autonomic alterations to pain]." Investigacion Clinica 48, no. 4 (December 2007): 469-483.
- Avila-Peña, D, Peña, N, Quintero, L, and Suárez-Roca, H. "Antinociceptive activity of Syzygium jambos leaves extract on rats." Journal of Ethnopharmacology 112, no. 2 (June 2007): 380-385. Full Text
- Suarez-Roca, H, Quintero, L, Arcaya, JL, Maixner, W, and Rao, SG. "Stress-induced muscle and cutaneous hyperalgesia: differential effect of milnacipran." Physiology & Behavior 88, no. 1-2 (June 2006): 82-87. Full Text
- Suarez-Roca, H, Silva, JA, Arcaya, JL, Quintero, L, Maixner, W, and Pinerua-Shuhaibar, L. "Role of mu-opioid and NMDA receptors in the development and maintenance of repeated swim stress-induced thermal hyperalgesia." Behavioural Brain Research 167, no. 2 (February 2006): 205-211. Full Text
- Uzcátegui, B, Avila, D, Suárez-Roca, H, Quintero, L, Ortega, J, and González, B. "Anti-inflammatory, antinociceptive, and antipyretic effects of Lantana trifolia Linnaeus in experimental animals." Investigacion Clinica 45, no. 4 (December 2004): 317-322.
- Rodríguez, LJ, Medina, Y, Suárez-Roca, H, De Angel, BM, Israel, A, Charris, JE, López, SE, Caldera, JA, and Angel-Guio, JE. "Conformational theoretical study of substituted and non-substituted N-aralkyl-2-aminoindans and its relation with dopaminergic activity." Journal of Molecular Structure: Theochem 636, no. 1-3 (September 30, 2003): 1-8. Full Text
- Suarez-Roca, H, Piñerua-Shuhaibar, L, Morales, ME, and Maixner, W. "Increased perception of post-ischemic paresthesias in depressed subjects." Journal of Psychosomatic Research 55, no. 3 (September 2003): 253-257. Full Text
- Quintero, L, Cuesta, MC, Silva, JA, Arcaya, JL, Pinerua-Suhaibar, L, Maixner, W, and Suarez-Roca, H. "Repeated swim stress increases pain-induced expression of c-Fos in the rat lumbar cord." Brain Research 965, no. 1-2 (March 2003): 259-268. Full Text
- Suarez-Roca, H, and Cubeddu, LX. "The selective serotonin reuptake inhibitor citalopram induces the storage of serotonin in catecholaminergic terminals." The Journal of Pharmacology and Experimental Therapeutics 302, no. 1 (July 2002): 174-179. Full Text
- Cuesta, MC, Quintero, L, Pons, H, and Suarez-Roca, H. "Substance P and calcitonin gene-related peptide increase IL-1 beta, IL-6 and TNF alpha secretion from human peripheral blood mononuclear cells." Neurochemistry International 40, no. 4 (April 2002): 301-306. Full Text
- Quintero, L, Moreno, M, Avila, C, Arcaya, J, Maixner, W, and Suarez-Roca, H. "Long-lasting delayed hyperalgesia after subchronic swim stress." Pharmacology, Biochemistry, and Behavior 67, no. 3 (November 2000): 449-458. Full Text
- González, B, Suárez-Roca, H, Bravo, A, Salas-Auvert, R, and Avila, D. "Chemical Composition And Biological Activity Of Extracts From Arrabidaea Bilabiata." Pharmaceutical Biology 38, no. 4 (October 2000): 287-290. Full Text
- González, B, Suárez-Roca, H, Bravo, A, Salas-Auvert, R, and Avila, D. "Chemical composition and biological activity of extracts from arrabidaea bilabiata." Pharmaceutical Biology 38, no. 4 (January 2000): 287-290. Full Text
- Cuesta, MC, Arcaya, JL, Cano, G, Sanchez, L, Maixner, W, and Suarez-Roca, H. "Opposite modulation of capsaicin-evoked substance P release by glutamate receptors." Neurochemistry International 35, no. 6 (December 1999): 471-478. Full Text
- Piñerua-Shuhaibar, L, Prieto-Rincon, D, Ferrer, A, Bonilla, E, Maixner, W, and Suarez-Roca, H. "Reduced tolerance and cardiovascular response to ischemic pain in minor depression." Journal of Affective Disorders 56, no. 2-3 (December 1999): 119-126. Full Text
- Cano, G, Arcaya, JL, Gómez, G, Maixner, W, and Suarez-Roca, H. "Multiphasic morphine modulation of substance P release from capsaicin-sensitive primary afferent fibers." Neurochemical Research 24, no. 10 (October 1999): 1203-1207. Full Text
- Arcaya, JL, Cano, G, Gómez, G, Maixner, W, and Suárez-Roca, H. "Dynorphin A increases substance P release from trigeminal primary afferent C-fibers." European Journal of Pharmacology 366, no. 1 (January 1999): 27-34. Full Text
- Cano, G, Suárez-Roca, H, and Bonilla, E. "Alterations of excitatory amino acid receptors in the brain of manganese-treated mice." Molecular and Chemical Neuropathology 30, no. 1-2 (January 1997): 41-52. Full Text
- Carrizo, E, Cano, G, Suarez-Roca, H, and Bonilla, E. "Motor activity and quantitative autoradiographic analysis of muscarinic receptors in the brain of rats subjected to the forced swimming test." Brain Research Bulletin 42, no. 2 (January 1997): 133-139. Full Text
- Cano, G, Suárez-Roca, H, and Bonilla, E. "Manganese poisoning reduces strychnine-insensitive glycine binding sites in the globus pallidus of the mouse brain." Investigacion Clinica 37, no. 4 (December 1996): 209-219.
- Suarez-Roca, H, and Maixner, W. "Morphine produces a biphasic modulation of substance P release from cultured dorsal root ganglion neurons." Neuroscience Letters 194, no. 1-2 (July 1995): 41-44. Full Text
- Cuesta de Di Zio, MC, Gómez, G, Bonilla, E, and Suarez-Roca, H. "Autoreceptor presynaptic control of dopamine release from striatum is lost at early stages of manganese poisoning." Life Sciences 56, no. 22 (January 1995): 1857-1864. Full Text
- Suarez-Roca, H, and Maixner, W. "Activation of kappa opioid receptors by U50488H and morphine enhances the release of substance P from rat trigeminal nucleus slices." The Journal of Pharmacology and Experimental Therapeutics 264, no. 2 (February 1993): 648-653.
- Suarez-Roca, H, and Maixner, W. "Delta-opioid-receptor activation by [D-Pen2,D-Pen5]enkephalin and morphine inhibits substance P release from trigeminal nucleus slices." European Journal of Pharmacology 229, no. 1 (December 1992): 1-7. Full Text
- Suarez-Roca, H, Abdullah, L, Zuniga, J, Madison, S, and Maixner, W. "Multiphasic effect of morphine on the release of substance P from rat trigeminal nucleus slices." Brain Research 579, no. 2 (May 1992): 187-194. Full Text
- Suarez-Roca, H, and Maixner, W. "Morphine produces a multiphasic effect on the release of substance P from rat trigeminal nucleus slices by activating different opioid receptor subtypes." Brain Research 579, no. 2 (May 1992): 195-203. Full Text
- Madison, S, Whitsel, EA, Suarez-Roca, H, and Maixner, W. "Sensitizing effects of leukotriene B4 on intradental primary afferents." Pain 49, no. 1 (April 1992): 99-104. Full Text
- Castro-Caraballo, F, Suárez-Roca, H, Estévez, J, and Bonilla, E. "[Spontaneous motor activity in mice overloaded with iron-dextran]." Investigacion Clinica 33, no. 3 (January 1992): 121-134.
- Morales, LM, Estévez, J, Suárez, H, Villalobos, R, Chacín de Bonilla, L, and Bonilla, E. "Nutritional evaluation of Huntington disease patients." Am J Clin Nutr 50, no. 1 (July 1989): 145-150. Full Text Link to Item
- Suarez-Roca, H, Lovenberg, T, and Cubeddu, LX. "Comparative dopamine-cholinergic mechanisms in the olfactory tubercle and the striatum: effects of metoclopramide." The Journal of Pharmacology and Experimental Therapeutics 243, no. 3 (December 1987): 840-851.
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Book Sections
- Suarez Roca, H. "Opposite opioid modulation of SP-containing primary afferents." In New Advances in Cardiovascular Physiology and Pharmacology. : Excerpta Médica International, Congress Series. Elservier Science Publisher, 1998. (Chapter)
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Conference Papers
- Suarez-Roca, H, and Maixner, W. "Opposite opioid modulation of substance P-containing primary afferents." 9th Latin American Congress of Physiological Sciences/2nd Scientific Meeting of the Latin American Society of Hypertension. CARACAS, VENEZUELA. September 1997.: ELSEVIER SCIENCE BV, January 1, 1998. Link to Item
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