Scholars@Duke
Henry Hsien-Chun Tseng

Henry Hsien-Chun Tseng

Associate Professor of Ophthalmology
Ophthalmology, Glaucoma
henry.tseng@duke.edu
Dukeeye Center, DUMC 3802, Durham, NC 27710
Duke Eye Center, 2351 Erwin Road, DUMC 3802, Durham, NC 27710

Scholarly Works - Journal articles

Artificial Intelligence-Assisted Structural Analysis of Bones with Paget's Disease of Bone and Osteoporosis: Lessons from Mouse Models.

Journal article Diagnostics (Basel) · August 18, 2026 Background/Objectives: Paget's disease of bone (PDB) and osteoporosis are chronic metabolic bone disorders characterized by disrupted bone remodeling and increased skeletal fragility; however, the underlying mechanism of PDB remains poorly understood. Arti ... Full text Link to item Cite

Optineurin modulates mTORC2/AKT/STAT3 signaling to control MHC class II expression and adaptive immunity against HSV-1

Journal article Cell Reports · April 28, 2026 SummaryHerpes simplex virus 1 (HSV-1) infection contributes to immunopathogenic diseases and lacks an effective vaccine. Improving antigen presentation is key to better vaccine strategies and more robust immune responses. Here, we show that optineurin (OPT ... Full text Cite

Artificial Intelligence-Guided Endpoint Selection for Neuroprotection Trials in Glaucoma.

Journal article Am J Ophthalmol · April 2026 OBJECTIVE: Standard Automated Perimetry (SAP) is the primary method for monitoring glaucoma progression and an established functional endpoint in clinical trials. A ≥7 dB loss in at least five prespecified test locations has been proposed as a potential en ... Full text Link to item Cite

Accelerated Epigenetic Aging Is Associated with Faster Glaucoma Progression: A DNA Methylation Study.

Journal article Ophthalmology · May 2025 PURPOSE: To investigate the association between epigenetic age acceleration and glaucoma progression. DESIGN: Retrospective cohort study. PARTICIPANTS: A total of 100 patients with primary open-angle glaucoma (POAG) with fast progression and 100 patients w ... Full text Link to item Cite

Intraocular Pressure Measurements With the Tono-Vera: A New Handheld Rebound Tonometer.

Journal article J Glaucoma · May 1, 2025 PRÉCIS: In a cross-sectional study comparing the novel Tono-Vera handheld rebound tonometer with the Ocular Response Analyzer, a strong agreement was found between the intraocular pressure measurements of the 2 devices. PURPOSE: To compare intraocular pres ... Full text Link to item Cite

Age-related effects of optineurin deficiency in the mouse eye.

Journal article Vision Res · November 2024 Optineurin (OPTN) is a gene associated with familial normal tension glaucoma (NTG). While NTG involves intraocular pressure (IOP)-independent neurodegeneration of the visual pathway that progresses with age, how OPTN dysfunction leads to NTG remains unclea ... Full text Link to item Cite

Short-term Detection of Fast Progressors in Glaucoma: The Fast Progression Assessment through Clustered Evaluation (Fast-PACE) Study.

Journal article Ophthalmology · June 2024 PURPOSE: To evaluate the performance of an intensive, clustered testing approach in identifying eyes with rapid glaucoma progression over 6 months in the Fast Progression Assessment through Clustered Evaluation (Fast-PACE) Study. DESIGN: Prospective cohort ... Full text Link to item Cite

Postoperative Management of Kahook Dual Blade Goniotomy with Phacoemulsification Cataract Extraction.

Journal article J Curr Glaucoma Pract · 2023 AIM: To review the efficacy and safety of two common postoperative regimens following Kahook Dual Blade goniotomy with phacoemulsification cataract extraction (KDB-CE). MATERIALS AND METHODS: This is a retrospective review of eyes undergoing KDB-CE from Ma ... Full text Link to item Cite

Intrinsic Antiviral Activity of Optineurin Prevents Hyperproliferation of a Primary Herpes Simplex Virus Type 2 Infection.

Journal article J Immunol · January 1, 2022 Very little knowledge exists on virus-specific host cell intrinsic mechanisms that prevent hyperproliferation of primary HSV type 2 (HSV-2) genital infections. In this study, we provide evidence that the Nemo-related protein, optineurin (OPTN), plays a key ... Full text Link to item Cite

OPTN is a host intrinsic restriction factor against neuroinvasive HSV-1 infection.

Journal article Nat Commun · September 13, 2021 Fast-replicating neurotropic herpesviruses exemplified by herpes simplex virus-1 (HSV-1) naturally infect the central nervous system (CNS). However, most individuals intrinsically suppress the virus during a primary infection and preclude it from significa ... Full text Link to item Cite

Roles of autophagy in orthodontic tooth movement.

Journal article Am J Orthod Dentofacial Orthop · May 2021 INTRODUCTION: Orthodontic tooth movement (OTM) relies on efficient remodeling of alveolar bone. While a well-controlled inflammatory response is essential during OTM, the mechanism regulating inflammation is unknown. Autophagy, a conserved catabolic pathwa ... Full text Link to item Cite

Deficiency of optineurin enhances osteoclast differentiation by attenuating the NRF2-mediated antioxidant response.

Journal article Exp Mol Med · April 2021 Abnormally increased resorption contributes to bone degenerative diseases such as Paget's disease of bone (PDB) through unclear mechanisms. Recently, the optineurin (OPTN) gene has been implicated in PDB, and global OPTN knockout mice (Optn-/-) were shown ... Full text Open Access Link to item Cite

Dopamine suppresses osteoclast differentiation via cAMP/PKA/CREB pathway.

Journal article Cell Signal · February 2021 How the nervous system regulates bone remodeling is an exciting area of emerging research in bone biology. Accumulating evidence suggest that neurotransmitter-mediated inputs from neurons may act directly on osteoclasts. Dopamine is a neurotransmitter that ... Full text Link to item Cite

Rates of Glaucomatous Structural and Functional Change From a Large Clinical Population: The Duke Glaucoma Registry Study.

Journal article Am J Ophthalmol · February 2021 PURPOSE: To investigate rates of structural and functional change in a large clinical population of glaucoma and glaucoma suspect patients. DESIGN: Retrospective cohort. METHODS: Twenty-nine thousand five hundred forty-eight spectral-domain optical coheren ... Full text Link to item Cite

Application of bioluminescence resonance energy transfer-based cell tracking approach in bone tissue engineering.

Journal article J Tissue Eng · 2021 Bioluminescent imaging (BLI) has emerged as a popular in vivo tracking modality in bone regeneration studies stemming from its clear advantages: non-invasive, real-time, and inexpensive. We recently adopted bioluminescence resonance energy transfer (BRET) ... Full text Open Access Link to item Cite

Respiratory pathology in the Optn-/- mouse model of Amyotrophic Lateral Sclerosis.

Journal article Respir Physiol Neurobiol · November 2020 Amyotrophic Lateral Sclerosis (ALS) is a devastating neurodegenerative disorder that results in death due to respiratory failure. Many genetic defects are associated with ALS; one such defect is a mutation in the gene encoding optineurin (OPTN). Using an o ... Full text Link to item Cite

Efficacy and safety of a single-use dual blade goniotomy: 18-month results.

Journal article J Cataract Refract Surg · October 2020 PURPOSE: To compare the 18-month efficacy and safety of Kahook Dual Blade goniotomy (KDB) in combination with cataract surgery (combined group) or as a standalone procedure (standalone group). SETTING: Single surgeon practice. DESIGN: Retrospective review ... Full text Link to item Cite

Retinal Ganglion Cells With a Glaucoma OPTN(E50K) Mutation Exhibit Neurodegenerative Phenotypes when Derived from Three-Dimensional Retinal Organoids.

Journal article Stem Cell Reports · July 14, 2020 Retinal ganglion cells (RGCs) serve as the connection between the eye and the brain, with this connection disrupted in glaucoma. Numerous cellular mechanisms have been associated with glaucomatous neurodegeneration, and useful cellular models of glaucoma a ... Full text Open Access Link to item Cite

Global deletion of Optineurin results in altered type I IFN signaling and abnormal bone remodeling in a model of Paget's disease.

Journal article Cell Death Differ · January 2020 Genome-wide association studies (GWAS) have identified Optineurin (OPTN) as genetically linked to Paget's disease of the bone (PDB), a chronic debilitating bone remodeling disorder characterized by localized areas of increased bone resorption and abnormal ... Full text Link to item Cite

Association of Open-Angle Glaucoma with Non-Alzheimer's Dementia and Cognitive Impairment.

Journal article Ophthalmol Glaucoma · 2020 PURPOSE: To compare the odds of central neurodegenerative diseases in patients with open-angle glaucoma (OAG) with the odds in patients without glaucoma (control patients). DESIGN: Cross-sectional study. PARTICIPANTS: Patients 18 years of age or older who ... Full text Link to item Cite

CDDO-Me, Sulforaphane and tBHQ attenuate the RANKL-induced osteoclast differentiation via activating the NRF2-mediated antioxidant response.

Journal article Biochem Biophys Res Commun · April 9, 2019 Metabolic bone diseases are global public health concerns and are primarily caused by uncontrolled osteoclast (OC) formation and activation. During OC differentiation, intracellular reactive oxygen species (ROS) stimulated by receptor activator of nuclear ... Full text Link to item Cite

Dopaminergic enhancement of cellular adhesion in bone marrow derived mesenchymal stem cells (MSCs).

Journal article J Stem Cell Res Ther · August 2017 Dopamine (DA) is a well-known neurotransmitter and critical element in the mussel adhesive protein that has gained increasing attention for its role in cellular growth enhancement in biomaterials, including cellular adhesion improvement. As the mechanism u ... Full text Link to item Cite

Cytokine biomarkers in tear film for primary open-angle glaucoma.

Journal article Clin Ophthalmol · 2017 PURPOSE: To determine the utility of tear film cytokines as biomarkers for early primary open-angle glaucoma (POAG). METHODS: Patients without POAG and eye drop-naïve patients with newly diagnosed POAG were recruited from an academic hospital-based glaucom ... Full text Open Access Link to item Cite

Retinal thinning in amyotrophic lateral sclerosis patients without ophthalmic disease.

Journal article PLoS One · 2017 IMPORTANCE: Amyotrophic lateral sclerosis (ALS) is a fatal, rapidly progressive neurodegenerative disease that primarily affects motor neurons. Recently, three causative genes have been implicated in both ALS and glaucoma. However, it is still uncertain wh ... Full text Link to item Cite

Method for single illumination source combined optical coherence tomography and fluorescence imaging of fluorescently labeled ocular structures in transgenic mice.

Journal article Exp Eye Res · October 2016 In vivo imaging permits longitudinal study of ocular disease processes in the same animal over time. Two different in vivo optical imaging modalities - optical coherence tomography (OCT) and fluorescence - provide important structural and cellular data res ... Full text Link to item Cite

Spectrum and Clinical Course of Visual Field Abnormalities in Ethambutol Toxicity.

Journal article Neuroophthalmology · June 2016 Visual toxicities from ethambutol are rare but represent one of the few causes of non-glaucomatous and non-compressive bitemporal hemianopsia. The authors present a six-patient case series illustrating variable clinical presentation and reversibility of vi ... Full text Link to item Cite

Visual impairment in an optineurin mouse model of primary open-angle glaucoma.

Journal article Neurobiol Aging · June 2015 Primary open-angle glaucoma (POAG) is characterized by progressive neurodegeneration of retinal ganglion cells (RGCs). Why RGCs degenerate in low-pressure POAG remains poorly understood. To gain mechanistic insights, we developed a novel mouse model based ... Full text Link to item Cite

Dopaminergic effects on in vitro osteogenesis.

Journal article Bone Res · 2015 Multiple growth factors (e.g., BMP2, TGF-β1, FGF2) and isolated genes have been shown to improve osteoblastic proliferation and mineralization, advancing bone tissue engineering. Among these factors, both polydopamine (PDA) and dopamine (DA) monomer have r ... Full text Link to item Cite

Risk factors for exposure of glaucoma drainage devices: a retrospective observational study.

Journal article BMJ Open · May 2, 2014 OBJECTIVES: The purpose of this study was to identify risk factors for exposure of glaucoma drainage devices (GDD). SETTING: This retrospective, observational study was conducted in the eye clinic of an academic medical centre. PARTICIPANTS: Participants i ... Full text Link to item Cite

Injuring neurons induces neuronal differentiation in a population of hippocampal precursor cells in culture.

Journal article Neurobiol Dis · April 2006 A novel population of hippocampal precursor cells (HPCs) that can be induced to differentiate into astrocytes and oligodendrocytes can be derived from hippocampal cultures grown in serum-free media. The HPCs are PDGF-responsive, do not proliferate with bFG ... Full text Link to item Cite

Differential localization of ErbB receptor ensembles influences their signaling in hippocampal neurons.

Journal article DNA Cell Biol · September 2005 Our studies indicate that ErbB complexes participate in both survival and synaptic plasticity signals of hippocampal neurons but in a manner that depends on the subcellular localization of the receptor ensembles. Using dissociated hippocampal cultures, we ... Full text Link to item Cite

Platelet-derived growth factor-BB pretreatment attenuates excitotoxic death in cultured hippocampal neurons.

Journal article Neurobiol Dis · 2005 Neuronal excitotoxic death results from excess stimulation by elevated levels of extracellular glutamate acting on N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors. While excitotoxicity is typically ... Full text Link to item Cite

Differential expression of GABA and glutamate-receptor subunits and enzymes involved in GABA metabolism between electrophysiologically identified hippocampal CA1 pyramidal cells and interneurons.

Journal article Epilepsia · February 2003 PURPOSE: The balance between synaptic excitation and inhibition within the hippocampus is critical for maintaining normal hippocampal function. Even mild reduction in inhibition or enhancement of excitation can produce seizures. Synaptic excitation is prod ... Full text Link to item Cite