Herman Ford Staats
Professor of Pathology
Areas of Research Interest:
Our laboratory studies methods to induce and regulate antigen-specific immune responses at the mucosal surfaces of the host. The mucosal tissues and surfaces are often the first site of contact with infectious agents, a common location of life-threatening cancers and in constant contact with environmental antigens. A better understanding of factors that control the induction and regulation of mucosal immune responses may aid the development of vaccines and treatments for infectious agents such as HIV and agents of bioterrorism, cancers and environmental allergies.
Research interests in the Staats’ lab currently focus on:
1. DISCOVERING AND DEVELOPING NOVEL MUCOSAL ADJUVANTS AND THEIR MECHANISM OF ACTION
Adjuvants are substances commonly added to vaccines that enhance the induction of protective immune responses to the vaccine antigen. We have been successful at identifying substances with mucosal adjuvant activity such as the pro-inflammatory cytokine interleukin 1α/β (IL-1α/β). IL-1α/β provides effective nasal adjuvant activity in mice, rabbits and non-human primates. Recent studies performed in collaboration with Dr. Soman Abraham have determined that the chemical mast cell activator compound 48/80 provides effective nasal adjuvant activity in mice and rabbits. Recent funding in the laboratory supported the discovery of small molecule mast cell activators with vaccine adjuvant activity. Current funding in the laboratory supports the discovery of IL-1 receptor agonists (small molecules, peptides, aptamers) that exhibit vaccine adjuvant activity.
2. OPTIMIZING NASAL IMMUNIZATION TO MAXIMIZE VACCINE IMMUNOGENICITY
Nasal immunization studies in mice have demonstrated the ability of nasal immunization to induce protective immune responses equal to those induced by a vaccine delivered with a needle. However, when nasal immunization is performed in rabbits or non-human primates, animals with a nasal cavity structure/anatomy that closely resembles the human nasal cavity, nasal immunization is often not as effective as immunization delivered with a needle. Studies in our lab have demonstrated that an increased nasal residence time in rabbits correlates with increased vaccine immunogenicity. Studies are being performed to develop vaccine delivery techniques and vaccine formulations that maximize nasal residence time and therefore, the immunogenicity of the vaccine. Nasal immunization studies performed in rabbits and non-human primates are performed to optimize nasal vaccine methods that may be tested in humans in the future.
3. EVALUATING FACTORS THAT INFLUENCE THE INDUCTION OF FOOD ALLERGY AND DEVELOPING NOVEL MUCOSAL TREATMENTS FOR FOOD ALLERGY
The number of individuals with food allergy in steadily increasing in developed countries. The administration of food allergens via mucosal routes, a procedure known as “mucosal immunotherapy”, has provided encouraging results suggesting that mucosal immunotherapy is able to modify the host anti-food allergen response to reduce the severity of allergic responses. A recent avenue of research in the laboratory is to 1) develop novel mucosal immunotherapy formulations to treat existing food allergy and 2) evaluate the influence of environmental factors on the induction and severity of food allergies.
Current Appointments & Affiliations
- Professor of Pathology, Pathology, Clinical Science Departments 2008
- Associate Professor of Immunology, Immunology, Basic Science Departments 2006
- Associate Professor of Medicine, Duke Human Vaccine Institute, Institutes and Centers 2007
- Member of the Duke Human Vaccine Institute, Duke Human Vaccine Institute, Institutes and Centers 2006
Contact Information
- 346M, Davison Building, Trent Drive, Durham, NC 27710
- Duke Box 3712, Durham, NC 27710
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herman.staats@duke.edu
(919) 684-8823
- Background
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Education, Training, & Certifications
- Research Associate, Medicine, Duke University 1995 - 1996
- Postdoctoral Fellow, Medicine, Duke University 1993 - 1995
- Ph.D., University of South Alabama 1992
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Previous Appointments & Affiliations
- Associate Professor of Pathology, Pathology, Clinical Science Departments 2006 - 2008
- Assistant Professor in Medicine, Duke Human Vaccine Institute, Institutes and Centers 2003 - 2006
- Assistant Professor in Pathology, Pathology, Clinical Science Departments 2003 - 2006
- Assistant Professor of Immunology, Immunology, Basic Science Departments 2003 - 2006
- Assistant Research Professor of Immunology, Immunology, Basic Science Departments 1996 - 2003
- Assistant Research Professor of Pathology, Pathology, Clinical Science Departments 1999 - 2003
- Assistant Research Professor in Medicine, Duke Human Vaccine Institute, Institutes and Centers 2002 - 2003
- Assistant Research Professor in Medicine, Medicine, Rheumatology and Immunology, Medicine 1996 - 2002
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Leadership & Clinical Positions at Duke
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2009 – 2020 Developmental Core Director, Duke University Center For AIDS Research
2015 – 2017 Chair, Institutional Animal Care and Use Committee
2016 – Present Vice Chair of Research, Department of Pathology
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- Recognition
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In the News
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FEB 5, 2020 Duke Health News
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- Expertise
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Subject Headings
- Research
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Selected Grants
- Basic Immunology Training Program awarded by National Institutes of Health 2020 - 2025
- A novel vaccination strategy to curb recUTIs awarded by National Institutes of Health 2023 - 2024
- Bacteriophage virus-like particle vaccines for fentanyl and heroin overdose awarded by University of New Mexico 2021 - 2024
- CIVICS Component A - Option 3 awarded by National Institutes of Health 2019 - 2023
- Adjuvant Comparison for Peanut Allergy Immunotherapy awarded by National Institutes of Health 2022 - 2023
- Quantitative Methods for HIV/AIDS Research awarded by National Institutes of Health 2018 - 2023
- Duke KURe Program awarded by National Institutes of Health 2013 - 2023
- Supramolecular peptide immunotherapies for peanut allergy awarded by National Institutes of Health 2021 - 2023
- Duke CTSA (TL1) Year 5 awarded by National Institutes of Health 2018 - 2023
- Gonorrhea Vaccine Cooperative Research Center (GV-CRC); Core C: Host Response Monitoring awarded by Henry M. Jackson Foundation 2019 - 2023
- Rational Design of Transferrin Binding Protein-based Vaccines to Combat Gonorrhea awarded by Georgia State University 2019 - 2023
- Vaccine Adjuvant Discovery Program awarded by University of Montana 2019 - 2022
- Research Training in Allergy and Clinical Immunology awarded by National Institutes of Health 2000 - 2022
- Utilizing intranasal immunization to induce a cytotoxic T lymphocyte response and reduce metastatic burden in the lung awarded by National Institutes of Health 2020 - 2021
- Transmission electron microscope (TEM) awarded by National Institutes of Health 2019 - 2021
- Developing a SARS-CoV-2 subunit vaccine for nasal immunization awarded by North Carolina Biotechnology Center 2020 - 2021
- Design and Engineering of VesiVax HIV Immunogen Formulations awarded by Molecular Express, Inc. 2020 - 2021
- Evaluation of Conjugated VesiVax Formulations for HIV Vaccines awarded by Molecular Express, Inc. 2020 - 2021
- Evaluation of VesiVax Adjuvant Formulations for HIV Vaccines awarded by Molecular Express, Inc. 2019 - 2021
- Immunotherapy to combat skin infections awarded by National Institutes of Health 2019 - 2021
- Adjuvant Discovery Program (Option #3) awarded by National Institutes of Health 2014 - 2020
- Self-replicating RNA Vaccine for HIV-1 Delivered using a Nanoparticle Adjuvant Formulation awarded by PAI Life Sciences 2019 - 2020
- Novel Adjuvants and Carriers for Opiod Vaccines awarded by National Institutes of Health 2014 - 2020
- Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
- Core C: Monitoring Host Response awarded by Henry M. Jackson Foundation 2014 - 2020
- Adjuvant Discovery Program (Option #2) awarded by National Institutes of Health 2014 - 2019
- Development of a Peanut Allergy Immunotherapy awarded by Molecular Express, Inc. 2017 - 2019
- Rational design of transferrin binding protein-based vaccines to combat gonorrhea awarded by Virginia Commonwealth University 2017 - 2019
- Pregnant rabbits as a model to evaluate the causative role of ZIKV infection in the etiology of congenital malformations awarded by National Institutes of Health 2017 - 2018
- Selection of a VesiVax vaccine for West Nile Virus awarded by Molecular Express, Inc. 2017 - 2018
- Understanding the Mechanism of Mucosal Immunotherapy awarded by University of North Carolina - Chapel Hill 2012 - 2018
- Serial Block Face Scanning Electron Microscope awarded by National Institutes of Health 2016 - 2018
- Overcoming Immunosenescence by Nanoparticle-Mediated Activation awarded by Columbia University 2017 - 2018
- Adjuvant Discovery Program (Option #1) awarded by National Institutes of Health 2014 - 2017
- Innate immune adaptations of hibernation as a new approach to protection against acute organ injury awarded by Society of Cardiovascular Anesthesiologists 2015 - 2017
- Mucosal vaccination to protect against HIV-1 infection at mucosal sites awarded by National Institutes of Health 2012 - 2017
- Adjuvant Discovery Program awarded by National Institutes of Health 2014 - 2017
- Study protocol 8. TrichGuard and TrichGuard V5L LCM project (Option B) awarded by Boehringer Ingelheim Vetmedica, Inc. 2016
- Development of VesiVax Carbohydrate Conjugation Chemistry awarded by Molecular Express, Inc. 2013 - 2015
- Evaluation of the nasal adjuvant activity of angiotensin peptide Ang-(1-7) awarded by National Institutes of Health 2012 - 2015
- Overcoming Immunosenescence by Nanoparticle-Mediated Activation awarded by National Institutes of Health 2012 - 2014
- Core C: Immunology awarded by University of North Carolina - Chapel Hill 2009 - 2014
- Development of Efficacious and Stable Nasal Vaccine Formulations awarded by National Institutes of Health 2009 - 2014
- Sublingual Immunotherapy for Peanut Allergy awarded by National Institutes of Health 2008 - 2013
- Nasal adjuvant to enhance anti-cocaine vaccines awarded by National Institutes of Health 2011 - 2013
- Enterotoxin targeting and delivery mechanisms awarded by National Institutes of Health 2006 - 2012
- Understanding the Mechanism of Mucosal Immunotherapy awarded by National Institutes of Health 2007 - 2012
- Development of Efficacious Vaccine Against UTI's awarded by National Institutes of Health 2008 - 2011
- Nasal Vaccines: Mode of Action, Composition & Delivery awarded by National Institutes of Health 2006 - 2011
- Small cationic antimicrobial peptides: activators of innate & adaptive immunity awarded by National Institutes of Health 2008 - 2010
- Alternative Endpoints for Plague Challenge Models awarded by National Institutes of Health 2004 - 2008
- Novel Oral Adjuvant for Dental Vaccines awarded by National Institutes of Health 2004 - 2008
- Mast Cell Activator as Adjuvant for Biodefense Vaccines awarded by National Institutes of Health 2005 - 2007
- A Universal Env Immunogen for all HIV-1 Subtypes awarded by National Institutes of Health 2003 - 2006
- NCRR FACSAria Cell Sorter awarded by National Center for Research Resources 2004 - 2006
- Detection of in vivo ETEC vesicle production awarded by National Institutes of Health 2003 - 2006
- Immunogenicity of an HIV virus-like particle vaccine awarded by National Institutes of Health 2003 - 2006
- Epitope specificity of vaccine-induced anti-HIV IgG and IgA awarded by National Institutes of Health 2002 - 2003
- Aids Research awarded by National Institutes of Health 1989 - 2002
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External Relationships
- Mastezellen Bio Inc.
- NIH
- Vaccine Injury Compensation Program https://www.hrsa.gov/vaccine-compensation/index.html
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Cui, Z., Zeng, C., Huang, F., Yuan, F., Yan, J., Zhao, Y., … Wang, Q. (2022). Cas13d knockdown of lung protease Ctsl prevents and treats SARS-CoV-2 infection. Nat Chem Biol, 18(10), 1056–1064. https://doi.org/10.1038/s41589-022-01094-4Full Text Link to Item
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Landon, C. D., Dancourt, G., Shing, V., & Staats, H. F. (2021). Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits (Oryctolagus cuniculus). J Vis Exp, (173). https://doi.org/10.3791/62317Full Text Link to Item
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Ristroph, K. D., Rummaneethorn, P., Johnson-Weaver, B., Staats, H., & Prud’homme, R. K. (2021). Highly-loaded protein nanocarriers prepared by Flash NanoPrecipitation with hydrophobic ion pairing. Int J Pharm, 601, 120397. https://doi.org/10.1016/j.ijpharm.2021.120397Full Text Link to Item
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Johnson-Weaver, B. T., Choi, H. W., Yang, H., Granek, J. A., Chan, C., Abraham, S. N., & Staats, H. F. (2021). Nasal Immunization With Small Molecule Mast Cell Activators Enhance Immunity to Co-Administered Subunit Immunogens. Front Immunol, 12, 730346. https://doi.org/10.3389/fimmu.2021.730346Full Text Link to Item
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St John, A. L., Choi, H. W., Walker, Q. D., Blough, B., Kuhn, C. M., Abraham, S. N., & Staats, H. F. (2020). Novel mucosal adjuvant, mastoparan-7, improves cocaine vaccine efficacy. Npj Vaccines, 5(1), 12. https://doi.org/10.1038/s41541-020-0161-1Full Text Link to Item
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Smeekens, J. M., Johnson-Weaver, B. T., Hinton, A. L., Azcarate-Peril, M. A., Moran, T. P., Immormino, R. M., … Kulis, M. D. (2020). Fecal IgA, Antigen Absorption, and Gut Microbiome Composition Are Associated With Food Antigen Sensitization in Genetically Susceptible Mice. Front Immunol, 11, 599637. https://doi.org/10.3389/fimmu.2020.599637Full Text Link to Item
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St John, A. L., Choi, H. W., Walker, Q. D., Blough, B., Kuhn, C. M., Abraham, S. N., & Staats, H. F. (2020). Novel mucosal adjuvant, mastoparan-7, improves cocaine vaccine efficacy. Npj Vaccines, 5(1), 12. https://doi.org/10.1038/s41541-020-0161-1Full Text Open Access Copy Link to Item
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Johnson-Weaver, B. T., Sempowski, G. D., & Staats, H. F. (2019). Nasal peanut+ CpG immunotherapy enhances peanut-specific IFN-γ in Th2 cells and IL-10 in non-Th2 cells in mice. Allergy, 74(11), 2220–2223. https://doi.org/10.1111/all.13738Full Text Link to Item
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Jones, D. I., Pollara, J. J., Johnson-Weaver, B. T., LaBranche, C. C., Montefiori, D. C., Pickup, D. J., … Staats, H. F. (2019). Optimized Mucosal Modified Vaccinia Virus Ankara Prime/Soluble gp120 Boost HIV Vaccination Regimen Induces Antibody Responses Similar to Those of an Intramuscular Regimen. J Virol, 93(14). https://doi.org/10.1128/JVI.00475-19Full Text Link to Item
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Choi, H. W., Chan, C., Shterev, I. D., Lynch, H. E., Robinette, T. J., Johnson-Weaver, B. T., … Staats, H. F. (2019). Identification of Novel Mast Cell Activators Using Cell-Based High-Throughput Screening. Slas Discov, 24(6), 628–640. https://doi.org/10.1177/2472555219834699Full Text Link to Item
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Pollara, J., Jones, D. I., Huffman, T., Edwards, R. W., Dennis, M., Li, S. H., … Permar, S. R. (2019). Bridging Vaccine-Induced HIV-1 Neutralizing and Effector Antibody Responses in Rabbit and Rhesus Macaque Animal Models. J Virol, 93(10). https://doi.org/10.1128/JVI.02119-18Full Text Link to Item
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Arifuzzaman, M., Mobley, Y. R., Choi, H. W., Bist, P., Salinas, C. A., Brown, Z. D., … Abraham, S. N. (2019). MRGPR-mediated activation of local mast cells clears cutaneous bacterial infection and protects against reinfection. Sci Adv, 5(1), eaav0216. https://doi.org/10.1126/sciadv.aav0216Full Text Open Access Copy Link to Item
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Choi, H. W., Suwanpradid, J., Kim, I. H., Staats, H. F., Haniffa, M., MacLeod, A. S., & Abraham, S. N. (2018). Perivascular dendritic cells elicit anaphylaxis by relaying allergens to mast cells via microvesicles. Science, 362(6415). https://doi.org/10.1126/science.aao0666Full Text Link to Item
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Johnson-Weaver, B., Choi, H. W., Abraham, S. N., & Staats, H. F. (2018). Mast cell activators as novel immune regulators. Curr Opin Pharmacol, 41, 89–95. https://doi.org/10.1016/j.coph.2018.05.004Full Text Link to Item
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Johnson-Weaver, B. T., McRitchie, S., Mercier, K. A., Pathmasiri, W., Sumner, S. J., Chan, C., … Staats, H. F. (2018). Effect of endotoxin and alum adjuvant vaccine on peanut allergy. J Allergy Clin Immunol, 141(2), 791-794.e8. https://doi.org/10.1016/j.jaci.2017.07.043Full Text Link to Item
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Staats, H. F., & Burkhart, D. J. (2018). Softness makes it better. Nat Mater, 17(2), 113–114. https://doi.org/10.1038/nmat5072Full Text Link to Item
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Johnson-Weaver, B. T., Staats, H. F., Burks, A. W., & Kulis, M. D. (2018). Adjuvanted Immunotherapy Approaches for Peanut Allergy. Front Immunol, 9, 2156. https://doi.org/10.3389/fimmu.2018.02156Full Text Link to Item
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Norton, J. N., Reynolds, R. P., Chan, C., Valdivia, R. H., & Staats, H. F. (2017). Assessing the satisfaction and burden within an academic animal care and use program. Faseb J, 31(9), 3913–3921. https://doi.org/10.1096/fj.201700072RRFull Text Link to Item
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Jones, D. I., McGee, C. E., Sample, C. J., Sempowski, G. D., Pickup, D. J., & Staats, H. F. (2016). Modified Vaccinia Ankara Virus Vaccination Provides Long-Term Protection against Nasal Rabbitpox Virus Challenge. Clin Vaccine Immunol, 23(7), 648–651. https://doi.org/10.1128/CVI.00216-16Full Text Link to Item
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Nelson, C. S., Pollara, J., Kunz, E. L., Jeffries, T. L., Duffy, R., Beck, C., … Permar, S. R. (2016). Combined HIV-1 Envelope Systemic and Mucosal Immunization of Lactating Rhesus Monkeys Induces a Robust Immunoglobulin A Isotype B Cell Response in Breast Milk. J Virol, 90(10), 4951–4965. https://doi.org/10.1128/JVI.00335-16Full Text Link to Item
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Samo, M., Choudhary, N. R., Riebe, K. J., Shterev, I., Staats, H. F., Sempowski, G. D., & Leduc, I. (2016). Immunization with the Haemophilus ducreyi trimeric autotransporter adhesin DsrA with alum, CpG or imiquimod generates a persistent humoral immune response that recognizes the bacterial surface. Vaccine, 34(9), 1193–1200. https://doi.org/10.1016/j.vaccine.2016.01.024Full Text Link to Item
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Phua, K. K. L., Staats, H. F., Nair, S. K., & Leong, K. W. (2015). Intranasal mRNA nanoparticle vaccination induces prophylactic and therapeutic anti-tumor immunity. J Control Release, 213, e66–e67. https://doi.org/10.1016/j.jconrel.2015.05.110Full Text Link to Item
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Roggelin, L., Vinnemeier, C. D., Fischer-Herr, J., Johnson-Weaver, B. T., Rolling, T., Burchard, G. D., … Cramer, J. P. (2015). Serological response following re-vaccination with Salmonella typhi Vi-capsular polysaccharide vaccines in healthy adult travellers. Vaccine, 33(33), 4141–4145. https://doi.org/10.1016/j.vaccine.2015.05.080Full Text Link to Item
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Bento, D., Staats, H. F., & Borges, O. (2015). Effect of particulate adjuvant on the anthrax protective antigen dose required for effective nasal vaccination. Vaccine, 33(31), 3609–3613. https://doi.org/10.1016/j.vaccine.2015.06.037Full Text Link to Item
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Bento, D., Staats, H. F., Gonçalves, T., & Borges, O. (2015). Development of a novel adjuvanted nasal vaccine: C48/80 associated with chitosan nanoparticles as a path to enhance mucosal immunity. Eur J Pharm Biopharm, 93, 149–164. https://doi.org/10.1016/j.ejpb.2015.03.024Full Text Link to Item
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Sayes, C. M., Staats, H., & Hickey, A. J. (2014). Scale of health: indices of safety and efficacy in the evolving environment of large biological datasets. Pharm Res, 31(9), 2256–2265. https://doi.org/10.1007/s11095-014-1415-2Full Text Link to Item
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Phua, K. K. L., Staats, H. F., Leong, K. W., & Nair, S. K. (2014). Intranasal mRNA nanoparticle vaccination induces prophylactic and therapeutic anti-tumor immunity. Sci Rep, 4, 5128. https://doi.org/10.1038/srep05128Full Text Link to Item
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Permar, S. R., & Staats, H. F. (2014). Which comes first: the antigen or the adjuvant? J Clin Invest, 124(6), 2364–2365. https://doi.org/10.1172/JCI76263Full Text Link to Item
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Majumder, P. P., Sarkar-Roy, N., Staats, H., Ramamurthy, T., Maiti, S., Chowdhury, G., … Wagener, D. K. (2014). Genomic correlates of variability in immune response to an oral cholera vaccine. Nature, 507(7490 SUPPL.), 1000–1006.
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Choi, H. W., Brooking-Dixon, R., Neupane, S., Lee, C.-J., Miao, E. A., Staats, H. F., & Abraham, S. N. (2013). Salmonella typhimurium impedes innate immunity with a mast-cell-suppressing protein tyrosine phosphatase, SptP. Immunity, 39(6), 1108–1120. https://doi.org/10.1016/j.immuni.2013.11.009Full Text Link to Item
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Sample, C. J., Hudak, K. E., Barefoot, B. E., Koci, M. D., Wanyonyi, M. S., Abraham, S., … Ramsburg, E. A. (2013). A mastoparan-derived peptide has broad-spectrum antiviral activity against enveloped viruses. Peptides, 48, 96–105. https://doi.org/10.1016/j.peptides.2013.07.014Full Text Link to Item
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Majumder, P. P., Sarkar-Roy, N., Staats, H., Ramamurthy, T., Maiti, S., Chowdhury, G., … Wagener, D. K. (2013). Genomic correlates of variability in immune response to an oral cholera vaccine. Eur J Hum Genet, 21(9), 1000–1006. https://doi.org/10.1038/ejhg.2012.278Full Text Link to Item
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Zaccaro, D. J., Wagener, D. K., Whisnant, C. C., & Staats, H. F. (2013). Evaluation of vaccine-induced antibody responses: impact of new technologies. Vaccine, 31(25), 2756–2761. https://doi.org/10.1016/j.vaccine.2013.03.065Full Text Link to Item
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Fouda, G. G. A., Amos, J. D., Wilks, A. B., Pollara, J., Ray, C. A., Chand, A., … Permar, S. R. (2013). Mucosal immunization of lactating female rhesus monkeys with a transmitted/founder HIV-1 envelope induces strong Env-specific IgA antibody responses in breast milk. J Virol, 87(12), 6986–6999. https://doi.org/10.1128/JVI.00528-13Full Text Link to Item
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Gwinn, W. M., Johnson, B. T., Kirwan, S. M., Sobel, A. E., Abraham, S. N., Gunn, M. D., & Staats, H. F. (2013). A comparison of non-toxin vaccine adjuvants for their ability to enhance the immunogenicity of nasally-administered anthrax recombinant protective antigen. Vaccine, 31(11), 1480–1489. https://doi.org/10.1016/j.vaccine.2013.01.012Full Text Link to Item
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Staats, H. F., Kirwan, S. M., Choi, H. W., Shelburne, C. P., Abraham, S. N., Leung, G. Y. C., & Chen, D.-K. (2013). A Mast Cell Degranulation Screening Assay for the Identification of Novel Mast Cell Activating Agents. Medchemcomm, 4(1). https://doi.org/10.1039/C2MD20073BFull Text Link to Item
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Kulis, M., Saba, K., Kim, E. H., Bird, J. A., Kamilaris, N., Vickery, B. P., … Burks, A. W. (2012). Increased peanut-specific IgA levels in saliva correlate with food challenge outcomes after peanut sublingual immunotherapy. J Allergy Clin Immunol, 129(4), 1159–1162. https://doi.org/10.1016/j.jaci.2011.11.045Full Text Link to Item
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Thompson, A. L., Johnson, B. T., Sempowski, G. D., Gunn, M. D., Hou, B., DeFranco, A. L., & Staats, H. F. (2012). Maximal adjuvant activity of nasally delivered IL-1α requires adjuvant-responsive CD11c(+) cells and does not correlate with adjuvant-induced in vivo cytokine production. J Immunol, 188(6), 2834–2846. https://doi.org/10.4049/jimmunol.1100254Full Text Link to Item
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St John, A. L., Chan, C. Y., Staats, H. F., Leong, K. W., & Abraham, S. N. (2012). Synthetic mast-cell granules as adjuvants to promote and polarize immunity in lymph nodes. Nat Mater, 11(3), 250–257. https://doi.org/10.1038/nmat3222Full Text Link to Item
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Wang, S. H., Kirwan, S. M., Abraham, S. N., Staats, H. F., & Hickey, A. J. (2012). Stable dry powder formulation for nasal delivery of anthrax vaccine. J Pharm Sci, 101(1), 31–47. https://doi.org/10.1002/jps.22742Full Text Link to Item
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Wang, S. H., Thompson, A. L., Hickey, A. J., & Staats, H. F. (2012). Dry powder vaccines for mucosal administration: critical factors in manufacture and delivery. Curr Top Microbiol Immunol, 354, 121–156. https://doi.org/10.1007/82_2011_167Full Text Link to Item
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Mestecky, J., Wright, P. F., Lopalco, L., Staats, H. F., Kozlowski, P. A., Moldoveanu, Z., … Hoelscher, M. (2011). Scarcity or absence of humoral immune responses in the plasma and cervicovaginal lavage fluids of heavily HIV-1-exposed but persistently seronegative women. Aids Res Hum Retroviruses, 27(5), 469–486. https://doi.org/10.1089/aid.2010.0169Full Text Link to Item
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Gwinn, W. M., Kirwan, S. M., Wang, S. H., Ashcraft, K. A., Sparks, N. L., Doil, C. R., … Staats, H. F. (2011). Erratum to " Effective induction of protective systemic immunity with nasally administered vaccines adjuvanted with IL-1" [Vaccine 28 (42) (2010) 6901-6914]. Vaccine, 29(15), 2821. https://doi.org/10.1016/j.vaccine.2011.01.096Full Text
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Staats, H. F., Fielhauer, J. R., Thompson, A. L., Tripp, A. A., Sobel, A. E., Maddaloni, M., … Pascual, D. W. (2011). Mucosal targeting of a BoNT/A subunit vaccine adjuvanted with a mast cell activator enhances induction of BoNT/A neutralizing antibodies in rabbits. Plos One, 6(1), e16532. https://doi.org/10.1371/journal.pone.0016532Full Text Link to Item
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Thompson, A. L., & Staats, H. F. (2011). Cytokines: the future of intranasal vaccine adjuvants. Clin Dev Immunol, 2011, 289597. https://doi.org/10.1155/2011/289597Full Text Link to Item
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Gwinn, W. M., Kirwan, S. M., Wang, S. H., Ashcraft, K. A., Sparks, N. L., Doil, C. R., … Staats, H. F. (2010). Effective induction of protective systemic immunity with nasally administered vaccines adjuvanted with IL-1. Vaccine, 28(42), 6901–6914. https://doi.org/10.1016/j.vaccine.2010.08.006Full Text Link to Item
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Fusco, W. G., Afonina, G., Nepluev, I., Cholon, D. M., Choudhary, N., Routh, P. A., … Elkins, C. (2010). Immunization with the Haemophilus ducreyi hemoglobin receptor HgbA with adjuvant monophosphoryl lipid A protects swine from a homologous but not a heterologous challenge. Infect Immun, 78(9), 3763–3772. https://doi.org/10.1128/IAI.00217-10Full Text Link to Item
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Clapp, B., Golden, S., Maddaloni, M., Staats, H. F., & Pascual, D. W. (2010). Adenovirus F protein as a delivery vehicle for botulinum B. Bmc Immunol, 11, 36. https://doi.org/10.1186/1471-2172-11-36Full Text Open Access Copy Link to Item
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Staats, H. F., & Leong, K. W. (2010). Polymer hydrogels: Chaperoning vaccines. Nat Mater, 9(7), 537–538. https://doi.org/10.1038/nmat2788Full Text Link to Item
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Staats, H. F., Kirwan, S. M., Whisnant, C. C., Stephenson, J. L., Wagener, D. K., & Majumder, P. P. (2010). Development of a bead immunoassay to measure Vi polysaccharide-specific serum IgG after vaccination with the Salmonella enterica serovar Typhi Vi polysaccharide. Clin Vaccine Immunol, 17(3), 412–419. https://doi.org/10.1128/CVI.00354-09Full Text Link to Item
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Majumder, P. P., Staats, H. F., Sarkar-Roy, N., Varma, B., Ghosh, T., Maiti, S., … Wagener, D. K. (2009). Genetic determinants of immune-response to a polysaccharide vaccine for typhoid. Hugo J, 3(1–4), 17–30. https://doi.org/10.1007/s11568-010-9134-1Full Text Link to Item
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Kunder, C. A., St John, A. L., Li, G., Leong, K. W., Berwin, B., Staats, H. F., & Abraham, S. N. (2009). Mast cell-derived particles deliver peripheral signals to remote lymph nodes. J Exp Med, 206(11), 2455–2467. https://doi.org/10.1084/jem.20090805Full Text Link to Item
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Shelburne, C. P., Nakano, H., St John, A. L., Chan, C., McLachlan, J. B., Gunn, M. D., … Abraham, S. N. (2009). Mast cells augment adaptive immunity by orchestrating dendritic cell trafficking through infected tissues. Cell Host Microbe, 6(4), 331–342. https://doi.org/10.1016/j.chom.2009.09.004Full Text Link to Item
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McGowen, A. L., Hale, L. P., Shelburne, C. P., Abraham, S. N., & Staats, H. F. (2009). The mast cell activator compound 48/80 is safe and effective when used as an adjuvant for intradermal immunization with Bacillus anthracis protective antigen. Vaccine, 27(27), 3544–3552. https://doi.org/10.1016/j.vaccine.2009.03.069Full Text Link to Item
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Hofmann, A. M., Staats, H. F., & Abraham, S. N. (2009). Use of a Mast Cell Activator as a Mucosal Adjuvant for Pertussis Vaccines. Journal of Allergy and Clinical Immunology, 123(2), S164–S164. https://doi.org/10.1016/j.jaci.2008.12.618Full Text
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Chen, Y.-H., Lipes, B. D., Kenan, D. J., Staats, H. F., & Gunn, M. D. (2009). Identification of recombinant antibodies against multiple distinct toll-like receptors by homolog mining a single immune scFv phage library. J Immunol Methods, 340(2), 144–153. https://doi.org/10.1016/j.jim.2008.10.013Full Text Link to Item
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Thompson, J. M., Whitmore, A. C., Staats, H. F., & Johnston, R. (2008). The contribution of type I interferon signaling to immunity induced by alphavirus replicon vaccines. Vaccine, 26(39), 4998–5003. https://doi.org/10.1016/j.vaccine.2008.07.011Full Text Link to Item
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Thompson, J. M., Whitmore, A. C., Staats, H. F., & Johnston, R. E. (2008). Alphavirus replicon particles acting as adjuvants promote CD8+ T cell responses to co-delivered antigen. Vaccine, 26(33), 4267–4275. https://doi.org/10.1016/j.vaccine.2008.05.046Full Text Link to Item
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Thompson, J. M., Nicholson, M. G., Whitmore, A. C., Zamora, M., West, A., Iwasaki, A., … Johnston, R. E. (2008). Nonmucosal alphavirus vaccination stimulates a mucosal inductive environment in the peripheral draining lymph node. J Immunol, 181(1), 574–585. https://doi.org/10.4049/jimmunol.181.1.574Full Text Link to Item
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Lipes, B. D., Chen, Y.-H., Ma, H., Staats, H. F., Kenan, D. J., & Gunn, M. D. (2008). An entirely cell-based system to generate single-chain antibodies against cell surface receptors. J Mol Biol, 379(2), 261–272. https://doi.org/10.1016/j.jmb.2008.03.072Full Text Link to Item
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McLachlan, J. B., Shelburne, C. P., Hart, J. P., Pizzo, S. V., Goyal, R., Brooking-Dixon, R., … Abraham, S. N. (2008). Mast cell activators: a new class of highly effective vaccine adjuvants. Nat Med, 14(5), 536–541. https://doi.org/10.1038/nm1757Full Text Link to Item
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Staats, H. F., Alam, S. M., Scearce, R. M., Kirwan, S. M., Zhang, J. X., Gwinn, W. M., & Haynes, B. F. (2007). In vitro and in vivo characterization of anthrax anti-protective antigen and anti-lethal factor monoclonal antibodies after passive transfer in a mouse lethal toxin challenge model to define correlates of immunity. Infect Immun, 75(11), 5443–5452. https://doi.org/10.1128/IAI.00529-07Full Text Link to Item
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Garmise, R. J., Staats, H. F., & Hickey, A. J. (2007). Novel dry powder preparations of whole inactivated influenza virus for nasal vaccination. Aaps Pharmscitech, 8(4), E81. https://doi.org/10.1208/pt0804081Full Text Link to Item
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McGowen, A., Paraggio, N. A., Sobel, A. E., Kirwan, S. M., Shelburne, C. P., Pizzo, S. V., … Staats, H. F. (2007). The mast cell activator Compound 48/80 is a potent adjuvant for intradermally-administered anthrax protective antigen. Journal of Immunology, 178.Link to Item
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Shelburne, C. P., St John, A., McLachlau, J. B., Staats, H. F., & Abraham, S. N. (2007). Mast cells enable heightened humoral immunity during infection. Journal of Immunology, 178.Link to Item
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Fujihashi, K., Staats, H. F., Kozaki, S., & Pascual, D. W. (2007). Mucosal vaccine development for botulinum intoxication. Expert Rev Vaccines, 6(1), 35–45. https://doi.org/10.1586/14760584.6.1.35Full Text Link to Item
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Hale, L. P., Fitzhugh, D. J., & Staats, H. F. (2006). Oral immunogenicity of the plant proteinase bromelain. Int Immunopharmacol, 6(13–14), 2038–2046. https://doi.org/10.1016/j.intimp.2006.08.007Full Text Link to Item
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Yu, J.-S., Peacock, J. W., Vanleeuwen, S., Hsu, T., Jacobs, W. R., Cayabyab, M. J., … Haynes, B. F. (2006). Generation of mucosal anti-human immunodeficiency virus type 1 T-cell responses by recombinant Mycobacterium smegmatis. Clin Vaccine Immunol, 13(11), 1204–1211. https://doi.org/10.1128/CVI.00195-06Full Text Link to Item
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Maddaloni, M., Staats, H. F., Mierzejewska, D., Hoyt, T., Robinson, A., Callis, G., … Pascual, D. W. (2006). Mucosal vaccine targeting improves onset of mucosal and systemic immunity to botulinum neurotoxin A. J Immunol, 177(8), 5524–5532. https://doi.org/10.4049/jimmunol.177.8.5524Full Text Link to Item
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Nordone, S. K., Peacock, J. W., Kirwan, S. M., & Staats, H. F. (2006). Capric acid and hydroxypropylmethylcellulose increase the immunogenicity of nasally administered peptide vaccines. Aids Res Hum Retroviruses, 22(6), 558–568. https://doi.org/10.1089/aid.2006.22.558Full Text Link to Item
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Thompson, J. M., Whitmore, A. C., Konopka, J. L., Collier, M. L., Richmond, E. M. B., Davis, N. L., … Johnston, R. E. (2006). Mucosal and systemic adjuvant activity of alphavirus replicon particles. Proc Natl Acad Sci U S A, 103(10), 3722–3727. https://doi.org/10.1073/pnas.0600287103Full Text Link to Item
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Haynes, B. F., Fleming, J., St Clair, E. W., Katinger, H., Stiegler, G., Kunert, R., … Alam, S. M. (2005). Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodies. Science, 308(5730), 1906–1908. https://doi.org/10.1126/science.1111781Full Text Link to Item
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Kobayashi, R., Kohda, T., Kataoka, K., Ihara, H., Kozaki, S., Pascual, D. W., … Fujihashi, K. (2005). A novel neurotoxoid vaccine prevents mucosal botulism. J Immunol, 174(4), 2190–2195. https://doi.org/10.4049/jimmunol.174.4.2190Full Text Link to Item
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Gopal, I. N., Quinn, A., Henry, S. C., Hamilton, J. D., Staats, H. F., & Frothingham, R. (2005). Nasal peptide vaccination elicits CD8 responses and reduces viral burden after challenge with virulent murine cytomegalovirus. Microbiol Immunol, 49(2), 113–119. https://doi.org/10.1111/j.1348-0421.2005.tb03710.xFull Text Link to Item
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Peacock, J. W., Nordone, S. K., Jackson, S. S., Liao, H.-X., Letvin, N. L., Yafal, A. G., … Staats, H. F. (2004). Gender differences in human immunodeficiency virus type 1-specific CD8 responses in the reproductive tract and colon following nasal peptide priming and modified vaccinia virus Ankara boosting. J Virol, 78(23), 13163–13172. https://doi.org/10.1128/JVI.78.23.13163-13172.2004Full Text Link to Item
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Egan, M. A., Chong, S. Y., Hagen, M., Megati, S., Schadeck, E. B., Piacente, P., … Staats, H. F. (2004). A comparative evaluation of nasal and parenteral vaccine adjuvants to elicit systemic and mucosal HIV-1 peptide-specific humoral immune responses in cynomolgus macaques. Vaccine, 22(27–28), 3774–3788. https://doi.org/10.1016/j.vaccine.2004.03.011Full Text Link to Item
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Qimron, U., Paul, L., Bar-Haim, E., Bloushtain, N., Eisenbach, L., Staats, H. F., & Porgador, A. (2004). Non-replicating mucosal and systemic vaccines: quantitative and qualitative differences in the Ag-specific CD8(+) T cell population in different tissues. Vaccine, 22(11–12), 1390–1394. https://doi.org/10.1016/j.vaccine.2003.11.043Full Text Link to Item
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McLachlan, J. B., Hart, J. P., Pizzo, S. V., Shelburne, C. P., Staats, H. F., Gunn, M. D., & Abraham, S. N. (2003). Mast cell-derived tumor necrosis factor induces hypertrophy of draining lymph nodes during infection. Nat Immunol, 4(12), 1199–1205. https://doi.org/10.1038/ni1005Full Text Link to Item
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Sufka, S. A., Ferrari, G., Gryszowka, V. E., Wrin, T., Fiscus, S. A., Tomaras, G. D., … Hicks, C. B. (2003). Prolonged CD4+ cell/virus load discordance during treatment with protease inhibitor-based highly active antiretroviral therapy: immune response and viral control. J Infect Dis, 187(7), 1027–1037. https://doi.org/10.1086/368359Full Text Link to Item
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Wright, P. F., Kozlowski, P. A., Rybczyk, G. K., Goepfert, P., Staats, H. F., VanCott, T. C., … Mestecky, J. (2002). Detection of mucosal antibodies in HIV type 1-infected individuals. Aids Res Hum Retroviruses, 18(17), 1291–1300. https://doi.org/10.1089/088922202320886334Full Text Link to Item
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Liao, H. X., Cianciolo, G. J., Staats, H. F., Scearce, R. M., Lapple, D. M., Stauffer, S. H., … Haynes, B. F. (2002). Increased immunogenicity of HIV envelope subunit complexed with alpha2-macroglobulin when combined with monophosphoryl lipid A and GM-CSF. Vaccine, 20(17–18), 2396–2403. https://doi.org/10.1016/s0264-410x(02)00090-7Full Text Link to Item
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Bradney, C. P., Sempowski, G. D., Liao, H.-X., Haynes, B. F., & Staats, H. F. (2002). Cytokines as adjuvants for the induction of anti-human immunodeficiency virus peptide immunoglobulin G (IgG) and IgA antibodies in serum and mucosal secretions after nasal immunization. J Virol, 76(2), 517–524. https://doi.org/10.1128/jvi.76.2.517-524.2002Full Text Link to Item
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Staats, H. F., Bradney, C. P., Gwinn, W. M., Jackson, S. S., Sempowski, G. D., Liao, H. X., … Haynes, B. F. (2001). Cytokine requirements for induction of systemic and mucosal CTL after nasal immunization. J Immunol, 167(9), 5386–5394. https://doi.org/10.4049/jimmunol.167.9.5386Full Text Link to Item
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Boyaka, P. N., Wright, P. F., Marinaro, M., Kiyono, H., Johnson, J. E., Gonzales, R. A., … McGhee, J. R. (2000). Human nasopharyngeal-associated lymphoreticular tissues. Functional analysis of subepithelial and intraepithelial B and T cells from adenoids and tonsils. Am J Pathol, 157(6), 2023–2035. https://doi.org/10.1016/S0002-9440(10)64841-9Full Text Link to Item
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Wilson, K. H., Brown, R. S., & Staats, H. F. (2000). Colonization of mice by human commensals engineered to produce tetanus toxin fragment C. Clinical Infectious Diseases, 31(1), 322–322.Link to Item
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Cheng, H., Tumpey, T. M., Staats, H. F., van Rooijen, N., Oakes, J. E., & Lausch, R. N. (2000). Role of macrophages in restricting herpes simplex virus type 1 growth after ocular infection. Invest Ophthalmol Vis Sci, 41(6), 1402–1409.Link to Item
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Laskowitz, D. T., Lee, D. M., Schmechel, D., & Staats, H. F. (2000). Altered immune responses in apolipoprotein E-deficient mice. J Lipid Res, 41(4), 613–620.Link to Item
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Haynes, B. F., Liao, H. X., Staats, H. F., Alam, M. S., Weinhold, K. J., & Montefiori, D. C. (2000). HIV vaccine development at Duke University Medical Center. Immunol Res, 22(2–3), 263–269. https://doi.org/10.1385/ir:22:2-3:263Full Text Link to Item
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Staats, H. F., & Ennis, F. A. (1999). IL-1 is an effective adjuvant for mucosal and systemic immune responses when coadministered with protein immunogens. J Immunol, 162(10), 6141–6147.Link to Item
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Staats, H. F., & Ennis, F. A. (1999). Mucosal adjuvanticity of interleukin. Faseb Journal, 13(4), A287–A287.Link to Item
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Porgador, A., Staats, H. F., Itoh, Y., & Kelsall, B. L. (1998). Intranasal immunization with cytotoxic T-lymphocyte epitope peptide and mucosal adjuvant cholera toxin: selective augmentation of peptide-presenting dendritic cells in nasal mucosa-associated lymphoid tissue. Infect Immun, 66(12), 5876–5881. https://doi.org/10.1128/IAI.66.12.5876-5881.1998Full Text Link to Item
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Lee, D. M., Staats, H. F., Sundy, J. S., Patel, D. D., Sempowski, G. D., Scearce, R. M., … Haynes, B. F. (1998). Immunologic characterization of CD7-deficient mice. J Immunol, 160(12), 5749–5756.Link to Item
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Staats, H. F., Montgomery, S. P., & Palker, T. J. (1997). Intranasal immunization is superior to vaginal, gastric, or rectal immunization for the induction of systemic and mucosal anti-HIV antibody responses. Aids Res Hum Retroviruses, 13(11), 945–952. https://doi.org/10.1089/aid.1997.13.945Full Text Link to Item
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Porgador, A., Staats, H. F., Faiola, B., Gilboa, E., & Palker, T. J. (1997). Intranasal immunization with CTL epitope peptides from HIV-1 or ovalbumin and the mucosal adjuvant cholera toxin induces peptide-specific CTLs and protection against tumor development in vivo. J Immunol, 158(2), 834–841.Link to Item
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Staats, H. F. (1997). Induction of MHC-Restricted CTL specific for distinct epitopes by intranasal immunization with a combination of CTL epitope peptides and the mucosal adjuvant cholera toxin. Journal of Allergy and Clinical Immunology, 99(1), 138–138.Link to Item
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Staats, H. F., Porgador, A., Faiola, B., Gilboa, E., & Palker, T. J. (1996). Induction of cytotoxic T lymphocytes (CTL) specific for HIV-1 or protection against tumor challenge by intranasal immunization with CTL peptide and cholera toxin. Faseb Journal, 10(6).
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Palker, T. J., Muir, A. J., Spragion, D. E., Staats, H. F., Langlois, A., & Montefiori, D. C. (1996). The V3 domain of SIVmac251 gp120 contains a linear neutralizing epitope. Virology, 224(2), 415–426. https://doi.org/10.1006/viro.1996.0548Full Text Link to Item
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Staats, H. F., Nichols, W. G., & Palker, T. J. (1996). Mucosal immunity to HIV-1: systemic and vaginal antibody responses after intranasal immunization with the HIV-1 C4/V3 peptide T1SP10 MN(A). J Immunol, 157(1), 462–472.Link to Item
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Staats, H. F., Porgador, A., Faiola, B., Gilboa, E., & Palker, T. J. (1996). Induction of cytotoxic T lymphocytes (CTL) specific for HIV-1 or protection against tumor challenge by intranasal immunization with CTL peptide and cholera toxin. Faseb Journal, 10(6), 1105–1105.Link to Item
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Takahashi, I., Kiyono, H., Jackson, R. J., Fujihashi, K., Staats, H. F., Hamada, S., … McGhee, J. R. (1996). Epitope maps of the Escherichia coli heat-labile toxin B subunit for development of a synthetic oral vaccine. Infect Immun, 64(4), 1290–1298. https://doi.org/10.1128/iai.64.4.1290-1298.1996Full Text Link to Item
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VanCott, J. L., Staats, H. F., Pascual, D. W., Roberts, M., Chatfield, S. N., Yamamoto, M., … McGhee, J. R. (1996). Regulation of mucosal and systemic antibody responses by T helper cell subsets, macrophages, and derived cytokines following oral immunization with live recombinant Salmonella. J Immunol, 156(4), 1504–1514.Link to Item
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Lee, D. M., Sundy, J. S., Staats, H. F., Patel, D. D., & Haynes, B. F. (1996). Initial characterization of cd7 deficient mice: evidence of a role for CD7 in regulation of thymocyte development. Journal of Investigative Medicine, 44(3).
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Marinaro, M., Staats, H. F., Hiroi, T., Jackson, R. J., Coste, M., Boyaka, P. N., … McGhee, J. R. (1995). Mucosal adjuvant effect of cholera toxin in mice results from induction of T helper 2 (Th2) cells and IL-4. J Immunol, 155(10), 4621–4629.Link to Item
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Horowitz, N. S., Staats, H. F., & Palker, T. J. (1995). Effect of bismuth salts on systemic and mucosal immune responses to orally administered cholera toxin. Immunopharmacology, 31(1), 31–41. https://doi.org/10.1016/0162-3109(95)00031-2Full Text Link to Item
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STAATS, H. F., & PALKER, T. J. (1995). INCREASED IMMUNOGENICITY OF PEPTIDES USED AS ORAL VACCINES BY COADMINISTRATION OF PROTEASE INHIBITORS. Faseb Journal, 9(3), A290–A290.Link to Item
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Jackson, R. J., Staats, H. F., Xu-Amano, J., Takahashi, I., Kiyono, H., Hudson, M. E., … McGhee, J. R. (1994). Oral vaccine models: multiple delivery systems employing tetanus toxoid. Ann N Y Acad Sci, 730, 217–234. https://doi.org/10.1111/j.1749-6632.1994.tb44251.xFull Text Link to Item
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Xu-Amano, J., Jackson, R. J., Fujihashi, K., Kiyono, H., Staats, H. F., & McGhee, J. R. (1994). Helper Th1 and Th2 cell responses following mucosal or systemic immunization with cholera toxin. Vaccine, 12(10), 903–911. https://doi.org/10.1016/0264-410x(94)90033-7Full Text Link to Item
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Staats, H. F., Jackson, R. J., Marinaro, M., Takahashi, I., Kiyono, H., & McGhee, J. R. (1994). Mucosal immunity to infection with implications for vaccine development. Curr Opin Immunol, 6(4), 572–583. https://doi.org/10.1016/0952-7915(94)90144-9Full Text Link to Item
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McGhee, J. R., Xu-Amano, J., Miller, C. J., Jackson, R. J., Fujihashi, K., Staats, H. F., & Kiyono, H. (1994). The common mucosal immune system: from basic principles to enteric vaccines with relevance for the female reproductive tract. Reprod Fertil Dev, 6(3), 369–379. https://doi.org/10.1071/rd9940369Full Text Link to Item
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Xu-Amano, J., Kiyono, H., Jackson, R. J., Staats, H. F., Fujihashi, K., Burrows, P. D., … McGhee, J. R. (1993). Helper T cell subsets for immunoglobulin A responses: oral immunization with tetanus toxoid and cholera toxin as adjuvant selectively induces Th2 cells in mucosa associated tissues. J Exp Med, 178(4), 1309–1320. https://doi.org/10.1084/jem.178.4.1309Full Text Link to Item
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Staats, H. F., & Lausch, R. N. (1993). Cytokine expression in vivo during murine herpetic stromal keratitis. Effect of protective antibody therapy. J Immunol, 151(1), 277–283.Link to Item
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Staats, H. F., Oakes, J. E., & Lausch, R. N. (1991). Anti-glycoprotein D monoclonal antibody protects against herpes simplex virus type 1-induced diseases in mice functionally depleted of selected T-cell subsets or asialo GM1+ cells. J Virol, 65(11), 6008–6014. https://doi.org/10.1128/JVI.65.11.6008-6014.1991Full Text Link to Item
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Lousch, R. N., Staats, H., Oakes, J. E., Cohen, G. H., & Eisenberg, R. J. (1991). Prevention of herpes keratitis by monoclonal antibodies specific for discontinuous and continuous epitopes on glycoprotein D. Invest Ophthalmol Vis Sci, 32(10), 2735–2740.Link to Item
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Lausch, R. N., Staats, H., Metcalf, J. F., & Oakes, J. E. (1990). Effective antibody therapy in herpes simplex virus ocular infection. Characterization of recipient immune response. Intervirology, 31(2–4), 159–165. https://doi.org/10.1159/000150150Full Text Link to Item
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Book Sections
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Johnson-Weaver, B., Abraham, S., & Staats, H. (2020). Innate Immunity based Mucosal Modulators and Adjuvants. In H. Kiyono & D. Pascual (Eds.), Mucosal Vaccines (pp. 167–183). Academic Press. https://doi.org/10.1016/C2016-0-00017-7Full Text Link to Item
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Choi, H. W., Johnson-Weaver, B., Staats, H., & Abraham, S. (2019). Mast Cells For the Control of Mucosal Immunity. In H. Kiyono & D. Pascual (Eds.), Mucosal Vaccines Innovation for Preventing Infectious Diseases. Academic Press.Link to Item
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Johnson-Weaver, B., Abraham, S., & Staats, H. (2019). Innate Immunity-Based Mucosal Modulators and Adjuvants. In H. Kiyono & D. Pascual (Eds.), Mucosal Vaccines Innovation for Preventing Infectious Diseases. Academic Press.Link to Item
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Hickey, A. J., Staats, H., Roy, C. J., Powell, K. G., Sullivan, V., Rothrock, G., & Sayes, C. M. (2014). Nasal dry powder vaccine delivery technology. In Molecular Vaccines: From Prophylaxis to Therapy - Volume 2 (pp. 717–726). https://doi.org/10.1007/978-3-319-00978-0_18Full Text
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Conference Papers
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Johnson-Weaver, B. T., Choi, H., Chan, C., Shterev, I., Abraham, S., & Staats, H. F. (2021). Nasal immunization with mast cell activating small molecules protects mice against West Nile Virus infection. In Journal of Immunology (Vol. 206).Link to Item
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Orgel, K. A., Smeekens, J., Johnson, B., Miller, D. R., Staats, H. F., Burks, A. W., … Kulis, M. D. (2019). Adjuvant-free intragastric sensitization to peanut promotes anaphylaxis in CC027/GeniUnc mice. In Journal of Allergy and Clinical Immunology (Vol. 143, pp. AB69–AB69). San Francisco, CA: MOSBY-ELSEVIER.Link to Item
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Pollara, J., Jones, D. I., Huffman, T., Dennis, M., Li, G., Goodman, D., … Permar, S. R. (2018). Bridging Vaccine-induced Antibody Responses in Rabbit and Rhesus Macaque Animal Models. In Aids Research and Human Retroviruses (Vol. 34, pp. 129–129). Madrid, SPAIN: MARY ANN LIEBERT, INC.Link to Item
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Choi, H. W., Brooking, R., Neupane, S., Lee, C.-J., Miao, E., Staats, H. F., & Abraham, S. N. (2014). Salmonella Typhimurium Impedes Innate Immunity With a Mast Cell-Suppressing Tyrosine Phosphatase Sptp. In Journal of Allergy and Clinical Immunology (Vol. 133, pp. AB247–AB247). Elsevier BV. https://doi.org/10.1016/j.jaci.2013.12.879Full Text
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Johnson, B. T., Kulis, M., Abraham, S. N., Burks, A. W., & Staats, H. F. (2012). Nasal Immunization with Peanut Antigen and The Cationic Peptide Adjuvant Mastoparan 7 Induces Serum Humoral Immunity That Protects Peanut Allergic Mice Against Systemic Anaphylaxis. In Journal of Allergy and Clinical Immunology (Vol. 129, pp. AB176–AB176). Elsevier BV. https://doi.org/10.1016/j.jaci.2011.12.221Full Text
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Hofmann, A. M., Jin, C., Staats, H. F., & Abraham, S. N. (2010). An In Vitro Model of Mast Cell Desensitization. In Journal of Allergy and Clinical Immunology (Vol. 125, pp. AB179–AB179). Elsevier BV. https://doi.org/10.1016/j.jaci.2009.12.702Full Text
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Hofmann, A. M., Staats, H. F., & Abraham, S. N. (2009). Mast cell activator as a mucosal adjuvant in intranasal pertussis vaccine. In Clinical and Experimental Allergy (Vol. 39, pp. 1940–1940). Nottingham, ENGLAND: WILEY-BLACKWELL PUBLISHING, INC.Link to Item
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Pons, L., Buchanan, A. D., Steele, P. H., Staats, H. F., & Burks, A. W. (2006). CD4+CD25high T Regulatory Cells in Egg-Allergic Children Undergoing Oral Desensitization. In Journal of Allergy and Clinical Immunology (Vol. 117, pp. S42–S42). Elsevier BV. https://doi.org/10.1016/j.jaci.2005.12.171Full Text
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Kadono, T., Staats, H. F., Steeber, D. A., Tedder, T. F., & Tamaki, K. (2004). Cutaneous and nasal immunity is L-selectin-dependent, whereas cooperation between L-selectin and beta 7 integrin is critical for intestinal immunity. In Journal of Investigative Dermatology (Vol. 122, pp. A117–A117). Providence, RI: BLACKWELL PUBLISHING INC.Link to Item
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Peacock, J. W., Nordone, S. K., Jackson, S., Liao, H. X., Letvin, N., Yafal, A. G., … Staats, H. F. (2003). Immunization that induces maximal HIV-specific cell-mediated immunity in the reproductive tract and colon of female mice is not optimal in male. In Faseb Journal (Vol. 17, pp. C320–C320). DENVER, COLORADO: FEDERATION AMER SOC EXP BIOL.Link to Item
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Steeber, D. A., Kadono, T., Staats, H. F., Venturi, G. M., Andrews, M. C., Wagner, N., & Tedder, T. F. (2003). Differential requirement for L-selectin- and beta 7 integrin-dependent lymphocyte migration in generation of gut- and nasal-associated mucosal immune responses. In Faseb Journal (Vol. 17, pp. C230–C230). DENVER, COLORADO: FEDERATION AMER SOC EXP BIOL.Link to Item
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- Teaching & Mentoring
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Recent Courses
- Scholarly, Clinical, & Service Activities
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Service to the Profession
- Editor. Clinical and Vaccine Immunology. 2014 - 2017 2014 - 2017
- Co-Chair. Abstract Programming, Immunotherapy and Vaccines. American Association of Immunologists Annual Meeting. 2011 - 2014 2011 - 2014
- Publications Committee member. American Association of Immunologists. 2010 - 2014 2010 - 2014
- NIH Study Section Member. Vaccines for Microbial Diseases (VMD). 2008 - 2012 2008 - 2012
- Section Editor. Journal of Immunology. 2006 - 2010 2006 - 2010
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Service to Duke
- Vice Chair of Research. Department of Pathology, Duke University School of Medicine. 2016 2016
- Chair, Institutional Animal Care and Use Committee. December 2015 - 2017 2015 - 2017
- Institutional Animal Care and Use Committee. 2013 - 2018 2013 - 2018
- Director. Center For AIDS Research Developmental Core. 2009 2009
- Basic Sciences Faculty Steering Committee. 2007 - 2018 2007 - 2018
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