Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Postdoctoral Fellow, Molecular Genetics, NIEHS 1994 - 1999
  • Ph.D., Pennsylvania State University 1994
  • B.S., North Carolina State University 1988
• 

  Duke Appointment History

  • Associate Research Professor in Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2014 - 2016
  • Associate Research Professor in the Institute for Genome Sciences & Policy, Institutes and Centers, School of Medicine 2006 - 2014
  • Assistant Research Professor of Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2002 - 2006
  • Assistant Research Professor of Genetics, School of Medicine, Duke University 2001 - 2002
• Research
• 

  Selected Grants

  • Duke Women's Reproductive Health Research Scholars awarded by National Institutes of Health 2020 - 2025
  • Training Program in Bioinformatics at the Intersection of Cancer Immunology and Microbiome awarded by National Institutes of Health 2020 - 2025
  • Microbiome Core Facility service for RNA quality assessment using the Agilent Bioanalyzer 2100 instrument NanoChip assay awarded by poweredRESEARCH 2021 - 2022
  • A comprehensive research resource to define mechanisms underlying microbial regulation of host metabolism in pediatric obesity and obesity-targeted therapeutics awarded by National Institutes of Health 2016 - 2021
  • A hands-on, integrative next-generation sequencing course: design, experiment, and analysis awarded by National Institutes of Health 2016 - 2020
  • Biodosimetry High-Throughput Test RFP-16-100-SOL-00010 awarded by DxTerity Diagnostics 2017 - 2019
  • 3D Biology Signatures defined by Nanostring Max System awarded by North Carolina Biotechnology Center 2018 - 2019
  • Single cell analysis of intratumoral heterogeneity in parathyroid neoplasia awarded by National Institutes of Health 2015 - 2017
  • Point of Care Biodosimeter awarded by Department of Health and Human Services 2009 - 2016
  • Alternative splicing and epithelial-mesenchymal plasticity in prostate tumors awarded by National Institutes of Health 2008 - 2014
  • Validating Molecular Signature Risk Models of NSCLC awarded by National Institutes of Health 2006 - 2012
  • Intellectual Property Challenges for the Development of Genomic Diagnostics awarded by National Institutes of Health 2009 - 2012
  • Molecular mechanisms of altered calcium sensing in human parathyroid disease awarded by National Institutes of Health 2010 - 2012
  • Novel Zebrafish Models to Study Toxicity of PCBs and Pesticides During Pregnancy awarded by National Institutes of Health 2007 - 2011
  • Neurosciences Microarray Center awarded by National Institutes of Health 2005 - 2011
  • Refining and Validating Genomic Signatures in Lung Cancer awarded by National Institutes of Health 2009 - 2010
  • Prospective Validation of Genomic Signatures of Chemosensitivity in NSCLC awarded by National Institutes of Health 2009 - 2010
  • Multiscale Integrative Immunology for Adjuvant Development awarded by National Institutes of Health 2005 - 2010
  • Duke-NHLBI Functional Microarray Facility awarded by National Institutes of Health 2002 - 2006
  • Neurosciences Microarray Center awarded by National Institutes of Health 2002 - 2005
  • Duke/NIDDK Functional Genomics Center awarded by National Institutes of Health 2000 - 2003
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Deveaux, April E., Tyler A. Allen, Muthana Al Abo, Xiaodi Qin, Dadong Zhang, Brendon M. Patierno, Lin Gu, et al. “RNA splicing and aggregate gene expression differences in lung squamous cell carcinoma between patients of West African and European ancestry.” Lung Cancer 153 (March 2021): 90–98. https://doi.org/10.1016/j.lungcan.2021.01.015.
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    • McCann, Jessica R., Nathan A. Bihlmeyer, Kimberly Roche, Cameron Catherine, Jayanth Jawahar, Lydia Coulter Kwee, Noelle E. Younge, et al. “The Pediatric Obesity Microbiome and Metabolism Study (POMMS): Methods, Baseline Data, and Early Insights.” Obesity (Silver Spring) 29, no. 3 (March 2021): 569–78. https://doi.org/10.1002/oby.23081.
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    • Dohlman, Anders B., Diana Arguijo Mendoza, Shengli Ding, Michael Gao, Holly Dressman, Iliyan D. Iliev, Steven M. Lipkin, and Xiling Shen. “The cancer microbiome atlas: a pan-cancer comparative analysis to distinguish tissue-resident microbiota from contaminants.” Cell Host Microbe 29, no. 2 (February 10, 2021): 281-298.e5. https://doi.org/10.1016/j.chom.2020.12.001.
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    • Holmes, Zachary C., Justin D. Silverman, Holly K. Dressman, Zhengzheng Wei, Eric P. Dallow, Sarah C. Armstrong, Patrick C. Seed, John F. Rawls, and Lawrence A. David. “Short-Chain Fatty Acid Production by Gut Microbiota from Children with Obesity Differs According to Prebiotic Choice and Bacterial Community Composition.” Mbio 11, no. 4 (August 11, 2020). https://doi.org/10.1128/mBio.00914-20.
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    • Armstrong, Sarah C., McAllister Windom, Nathan A. Bihlmeyer, Jennifer S. Li, Svati H. Shah, Mary Story, Nancy Zucker, et al. “Rationale and design of "Hearts & Parks": study protocol for a pragmatic randomized clinical trial of an integrated clinic-community intervention to treat pediatric obesity.” Bmc Pediatr 20, no. 1 (June 26, 2020): 308. https://doi.org/10.1186/s12887-020-02190-x.
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    • Iversen, Edwin S., Janice M. McCarthy, Kirsten Bell Burdett, Gary Lipton, Gary Phillips, Holly Dressman, Joel Ross, and Nelson Chao. “Bridging the gaps: using an NHP model to predict single dose radiation absorption in humans.” Int J Radiat Biol 96, no. 1 (January 2020): 47–56. https://doi.org/10.1080/09553002.2018.1532614.
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    • Balenga, Nariman, Pedram Azimzadeh, Joyce A. Hogue, Paul N. Staats, Yuhong Shi, James Koh, Holly Dressman, and John A. Olson. “Orphan Adhesion GPCR GPR64/ADGRG2 Is Overexpressed in Parathyroid Tumors and Attenuates Calcium-Sensing Receptor-Mediated Signaling.” J Bone Miner Res 32, no. 3 (March 2017): 654–66. https://doi.org/10.1002/jbmr.3023.
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    • Himburg, Heather A., Joshua Sasine, Xiao Yan, Jenny Kan, Holly Dressman, and John P. Chute. “A Molecular Profile of the Endothelial Cell Response to Ionizing Radiation.” Radiat Res 186, no. 2 (August 2016): 141–52. https://doi.org/10.1667/RR14444.1.
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    • Siamakpour-Reihani, Sharareh, Kouros Owzar, Chen Jiang, Peter M. Scarbrough, Oana I. Craciunescu, Janet K. Horton, Holly K. Dressman, Kimberly L. Blackwell, and Mark W. Dewhirst. “Genomic profiling in locally advanced and inflammatory breast cancer and its link to DCE-MRI and overall survival.” Int J Hyperthermia 31, no. 4 (June 2015): 386–95. https://doi.org/10.3109/02656736.2015.1016557.
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    • Zheng, Lingling, Xiao Yan, Sunil Suchindran, Holly Dressman, John P. Chute, and Joseph Lucas. “Biological pathway selection through Bayesian integrative modeling.” Stat Appl Genet Mol Biol 13, no. 4 (August 2014): 435–57. https://doi.org/10.1515/sagmb-2013-0043.
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    • Lucas, Joseph, Holly K. Dressman, Sunil Suchindran, Mai Nakamura, Nelson J. Chao, Heather Himburg, Kerry Minor, et al. “A translatable predictor of human radiation exposure.” Plos One 9, no. 9 (2014): e107897. https://doi.org/10.1371/journal.pone.0107897.
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    • Zheng, L., X. Yan, S. Suchindran, H. Dressman, J. P. Chute, and J. Lucas. “Biological pathway selection through Bayesian integrative modeling (Statistical Applications in Genetics and Molecular Biology).” Statistical Applications in Genetics and Molecular Biology 13, no. 6 (January 1, 2014): 733. https://doi.org/10.1515/sagmb-2014-0087.
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    • Freedman, Jennifer A., Christina K. Augustine, Angelica M. Selim, Kirsten C. Holshausen, Zhengzheng Wei, Katherine A. Tsamis, David S. Hsu, et al. “A methodology for utilization of predictive genomic signatures in FFPE samples.” Bmc Med Genomics 4 (July 11, 2011): 58. https://doi.org/10.1186/1755-8794-4-58.
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    • Koh, James, Moahad Dar, Brian R. Untch, Darshana Dixit, Yuhong Shi, Zhao Yang, Mohamed Abdelgadir Adam, et al. “Regulator of G protein signaling 5 is highly expressed in parathyroid tumors and inhibits signaling by the calcium-sensing receptor.” Mol Endocrinol 25, no. 5 (May 2011): 867–76. https://doi.org/10.1210/me.2010-0277.
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    • Salter, K. H., C. R. Acharya, K. S. Walters, R. Redman, A. Anguiano, K. S. Garman, C. K. Anders, et al. “An Integrated Approach to the Prediction of Chemotherapeutic Response in Patients with Breast Cancer.” Plos One 6, no. 9 (2011). https://doi.org/10.1371/journal.pone.0001908.
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    • Meadows, Sarah K., Holly K. Dressman, Pamela Daher, Heather Himburg, J Lauren Russell, Phuong Doan, Nelson J. Chao, Joseph Lucas, Joseph R. Nevins, and John P. Chute. “Diagnosis of partial body radiation exposure in mice using peripheral blood gene expression profiles.” Plos One 5, no. 7 (July 12, 2010): e11535. https://doi.org/10.1371/journal.pone.0011535.
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    • Barry, W., C. Acharya, M. B. Datto, H. K. Dressman, P. K. Marcom, N. Ready, G. S. Ginsburg, A. Potti, and J. R. Nevins. “Utilization of genomic signatures for chemotherapy response in prospective clinical studies.” Journal of Clinical Oncology 28, no. 15_suppl (May 20, 2010): 10513–10513. https://doi.org/10.1200/jco.2010.28.15_suppl.10513.
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    • Barry, William T., Dawn N. Kernagis, Holly K. Dressman, Ryan J. Griffis, J’vonne D. Hunter, John A. Olson, Jeff R. Marks, et al. “Intratumor heterogeneity and precision of microarray-based predictors of breast cancer biology and clinical outcome.” J Clin Oncol 28, no. 13 (May 1, 2010): 2198–2206. https://doi.org/10.1200/JCO.2009.26.7245.
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    • Barnett, Jason C., Sarah M. Bean, Regina S. Whitaker, Eiji Kondoh, Tsukasa Baba, Shingo Fujii, Jeffrey R. Marks, Holly K. Dressman, Susan K. Murphy, and Andrew Berchuck. “Ovarian cancer tumor infiltrating T-regulatory (T(reg)) cells are associated with a metastatic phenotype.” Gynecol Oncol 116, no. 3 (March 2010): 556–62. https://doi.org/10.1016/j.ygyno.2009.11.020.
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    • Tebbit, Christopher L., Jun Zhai, Brian R. Untch, Matthew J. Ellis, Holly K. Dressman, Rex C. Bentley, Jay A. Baker, et al. “Novel tumor sampling strategies to enable microarray gene expression signatures in breast cancer: a study to determine feasibility and reproducibility in the context of clinical care.” Breast Cancer Res Treat 118, no. 3 (December 2009): 635–43. https://doi.org/10.1007/s10549-008-0301-1.
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    • Marcom, P. K., M. B. Datto, W. T. Barry, J. Geradts, T. L. Foster, H. K. Dressman, J. Olson, A. Potti, G. Ginsburg, and J. R. Nevins. “Implementation of genomic predictors of chemotherapy response for guiding preoperative therapy in a prospective breast cancer trial.” J Clin Oncol 27, no. 15_suppl (May 20, 2009): 11057.
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    • Boren, Todd, Yin Xiong, Ardeshir Hakam, Robert Wenham, Sachin Apte, Gina Chan, Siddharth G. Kamath, Dung-Tsa Chen, Holly Dressman, and Johnathan M. Lancaster. “MicroRNAs and their target messenger RNAs associated with ovarian cancer response to chemotherapy.” Gynecol Oncol 113, no. 2 (May 2009): 249–55. https://doi.org/10.1016/j.ygyno.2009.01.014.
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    • Berchuck, Andrew, Edwin S. Iversen, Jingqin Luo, Jennifer P. Clarke, Hisani Horne, Douglas A. Levine, Jeff Boyd, et al. “Microarray analysis of early stage serous ovarian cancers shows profiles predictive of favorable outcome.” Clin Cancer Res 15, no. 7 (April 1, 2009): 2448–55. https://doi.org/10.1158/1078-0432.CCR-08-2430.
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    • Hsu, David S., Chaitanya R. Acharya, Bala S. Balakumaran, Richard F. Riedel, Mickey K. Kim, Marvaretta Stevenson, Sascha Tuchman, et al. “Characterizing the developmental pathways TTF-1, NKX2-8, and PAX9 in lung cancer.” Proc Natl Acad Sci U S A 106, no. 13 (March 31, 2009): 5312–17. https://doi.org/10.1073/pnas.0900827106.
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    • Pilon, Andre M., Murat O. Arcasoy, Holly K. Dressman, Serena E. Vayda, Yelena D. Maksimova, Jose I. Sangerman, Patrick G. Gallagher, and David M. Bodine. “Failure of terminal erythroid differentiation in EKLF-deficient mice is associated with cell cycle perturbation and reduced expression of E2F2.” Mol Cell Biol 28, no. 24 (December 2008): 7394–7401. https://doi.org/10.1128/MCB.01087-08.
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    • Boren, Todd, Yin Xiong, Ardeshir Hakam, Robert Wenham, Sachin Apte, ZhengZheng Wei, Siddharth Kamath, Dung-Tsa Chen, Holly Dressman, and Johnathan M. Lancaster. “MicroRNAs and their target messenger RNAs associated with endometrial carcinogenesis.” Gynecol Oncol 110, no. 2 (August 2008): 206–15. https://doi.org/10.1016/j.ygyno.2008.03.023.
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    • Haskins, Kylie A., Jonathan F. Russell, Nathan Gaddis, Holly K. Dressman, and Alejandro Aballay. “Unfolded protein response genes regulated by CED-1 are required for Caenorhabditis elegans innate immunity.” Dev Cell 15, no. 1 (July 2008): 87–97. https://doi.org/10.1016/j.devcel.2008.05.006.
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    • Barry, W. T., M. Datto, J. Geradts, T. Foster, J. Olson, P. K. Marcom, H. K. Dressman, J. R. Nevins, G. Ginsburg, and A. Potti. “Genomic-based signatures of chemosensitivity and ER/HER2 status in biologic replicate breast cancer samples.” J Clin Oncol 26, no. 15_suppl (May 20, 2008): 11068.
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    • Cragun, J. M., T. Boren, Y. Xiong, M. Indermaur, S. Kamath, H. Cottrill, L. Balducci, et al. “Gene expression determinants of ovarian cancer platinum-response in older women.” J Clin Oncol 26, no. 15_suppl (May 20, 2008): 22059.
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    • Cragun, J. M., T. Boren, Y. Xiong, M. Indermaur, S. Kamath, H. Cottrill, L. Balducci, et al. “Gene expression determinants of ovarian cancer platinum-response in older women.” Journal of Clinical Oncology 26, no. 15_suppl (May 20, 2008): 22059–22059. https://doi.org/10.1200/jco.2008.26.15_suppl.22059.
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    • Hsu, S. D., C. R. Acharya, R. F. Riedel, R. C. Redman, K. S. Garman, H. K. Dressman, G. Ginsburg, S. Powers, D. Mu, and A. Potti. “Use of co-activation of lung cancer specific developmental pathway genes, TTF-1, NKX2-8, and PAX9, to predict prognosis and guide therapeutic strategies.” J Clin Oncol 26, no. 15_suppl (May 20, 2008): 7511.
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    • Hsu, S. D., C. R. Acharya, R. F. Riedel, R. C. Redman, K. S. Garman, H. K. Dressman, G. Ginsburg, S. Powers, D. Mu, and A. Potti. “Use of co-activation of lung cancer specific developmental pathway genes, TTF-1, NKX2–8, and PAX9, to predict prognosis and guide therapeutic strategies.” Journal of Clinical Oncology 26, no. 15_suppl (May 20, 2008): 7511–7511. https://doi.org/10.1200/jco.2008.26.15_suppl.7511.
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    • Salter, K. H., B. A. Perez, C. R. Acharya, K. S. Walters, A. Anguiano, C. K. Anders, H. K. Dressman, P. K. Marcom, J. R. Nevins, and A. Potti. “Integration of clinico-pathologic variables, mRNA, and microRNA profiles represents an optimal strategy to predict sensitivity to chemotherapeutic agents in breast cancer.” J Clin Oncol 26, no. 15_suppl (May 20, 2008): 14567.
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    • Acharya, Chaitanya R., David S. Hsu, Carey K. Anders, Ariel Anguiano, Kelly H. Salter, Kelli S. Walters, Richard C. Redman, et al. “Gene expression signatures, clinicopathological features, and individualized therapy in breast cancer.” Jama 299, no. 13 (April 2, 2008): 1574–87. https://doi.org/10.1001/jama.299.13.1574.
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    • Meadows, Sarah K., Holly K. Dressman, Garrett G. Muramoto, Heather Himburg, Alice Salter, ZhengZheng Wei, Geoffrey S. Ginsburg, Nelson J. Chao, Joseph R. Nevins, and John P. Chute. “Gene expression signatures of radiation response are specific, durable and accurate in mice and humans.” Plos One 3, no. 4 (April 2, 2008): e1912. https://doi.org/10.1371/journal.pone.0001912.
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    • Salter, Kelly H., Chaitanya R. Acharya, Kelli S. Walters, Richard Redman, Ariel Anguiano, Katherine S. Garman, Carey K. Anders, et al. “An integrated approach to the prediction of chemotherapeutic response in patients with breast cancer.” Plos One 3, no. 4 (April 2, 2008): e1908. https://doi.org/10.1371/journal.pone.0001908.
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    • Boren, T., H. K. Dressman, S. Kamath, Z. Z. Wei, J. Cragun, M. Humphrey, N. Chen, Y. Xiong, and J. M. Lancaster. “MicroRNAs and their target messenger RNAs associated with the development of endometrial carcinoma.” Gynecologic Oncology 108, no. 3 (March 1, 2008): S88–89.
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    • Boren, T., H. K. Dressman, Z. Z. Wei, M. A. Martino, T. Zhang, J. Palmer, and J. M. Lancaster. “Gene expression patterns in formalin-fixed, paraffin-embedded endometrial tissue associated with lymph node metastasis.” Gynecologic Oncology 108, no. 3 (March 1, 2008): S89–90.
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    • Indermaur, M. D., T. Boren, J. Cragun, R. Wenham, S. Aptel, G. Chan, S. G. Karnath, Z. Wei, H. K. Dressman, and J. M. Lancaster. “Formalin-fixed, paraffin-embedded ovarian cancer gene expression signatures associated with platinum response.” Gynecologic Oncology 108, no. 3 (March 1, 2008): S39–S39.
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    • Indermaur, M. D., T. Boren, S. G. Kamath, Z. Wei, R. Wenham, S. Apte, H. K. Dressman, and J. M. Lancaster. “Targeted therapy to improve endometrial cancer response to doxorubicin.” Gynecologic Oncology 108, no. 3 (March 1, 2008): S82–S82.
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    • Hsu, David S., Bala S. Balakumaran, Chaitanya R. Acharya, Vanja Vlahovic, Kelli S. Walters, Katherine Garman, Carey Anders, et al. “Pharmacogenomic strategies provide a rational approach to the treatment of cisplatin-resistant patients with advanced cancer.” J Clin Oncol 25, no. 28 (October 1, 2007): 4350–57. https://doi.org/10.1200/JCO.2007.11.0593.
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    • Dressman, Holly K., Garrett G. Muramoto, Nelson J. Chao, Sarah Meadows, Dawn Marshall, Geoffrey S. Ginsburg, Joseph R. Nevins, and John P. Chute. “Gene expression signatures that predict radiation exposure in mice and humans.” Plos Med 4, no. 4 (April 2007): e106. https://doi.org/10.1371/journal.pmed.0040106.
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    • Learn, Chris A., Peter M. Grossi, Robert J. Schmittling, Weihua Xie, Duane A. Mitchell, Isaac Karikari, ZhengZheng Wei, Holly Dressman, and John H. Sampson. “Genetic analysis of intracranial tumors in a murine model of glioma demonstrate a shift in gene expression in response to host immunity.” J Neuroimmunol 182, no. 1–2 (January 2007): 63–72. https://doi.org/10.1016/j.jneuroim.2006.09.016.
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    • Learn, Chris A., Peter E. Fecci, Robert J. Schmittling, Weihua Xie, Isaac Karikari, Duane A. Mitchell, Gary E. Archer, ZhengZheng Wei, Holly Dressman, and John H. Sampson. “Profiling of CD4+, CD8+, and CD4+CD25+CD45RO+FoxP3+ T cells in patients with malignant glioma reveals differential expression of the immunologic transcriptome compared with T cells from healthy volunteers.” Clin Cancer Res 12, no. 24 (December 15, 2006): 7306–15. https://doi.org/10.1158/1078-0432.CCR-06-1727.
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    • Cheng, Skye H., Cheng-Fang Horng, Mike West, Erich Huang, Jennifer Pittman, Mei-Hua Tsou, Holly Dressman, et al. “Genomic prediction of locoregional recurrence after mastectomy in breast cancer.” J Clin Oncol 24, no. 28 (October 1, 2006): 4594–4602. https://doi.org/10.1200/JCO.2005.02.5676.
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    • Lancaster, J. M., H. K. Dressman, J. P. Clarke, R. A. Sayer, M. A. Martino, J. M. Cragun, A. H. Henriott, et al. “Identification of genes associated with ovarian cancer metastasis using microarray expression analysis.” Int J Gynecol Cancer 16, no. 5 (September 2006): 1733–45. https://doi.org/10.1111/j.1525-1438.2006.00660.x.
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    • Gollob, Jared A., Catherine J. Sciambi, Bercedis L. Peterson, Tina Richmond, Monica Thoreson, Kelly Moran, Holly K. Dressman, Jaroslav Jelinek, and Jean-Pierre J. Issa. “Phase I trial of sequential low-dose 5-aza-2'-deoxycytidine plus high-dose intravenous bolus interleukin-2 in patients with melanoma or renal cell carcinoma.” Clin Cancer Res 12, no. 15 (August 1, 2006): 4619–27. https://doi.org/10.1158/1078-0432.CCR-06-0883.
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    • Dressman, Holly K., Andrea Bild, Jennifer Garst, David Harpole, and Anil Potti. “Genomic signatures in non-small-cell lung cancer: targeting the targeted therapies.” Curr Oncol Rep 8, no. 4 (July 2006): 252–57. https://doi.org/10.1007/s11912-006-0029-1.
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    • Potti, A., H. K. Dressman, A. Bild, R. Riedel, M. Kelley, G. Ginsburg, J. Lancaster, J. Nevins, and P. Febbo. “A genomic strategy to combinatorial therapeutics in solid tumors.” J Clin Oncol 24, no. 18_suppl (June 20, 2006): 2031.
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    • Chute, John P., Garrett G. Muramoto, Holly K. Dressman, Gary Wolfe, Nelson J. Chao, and Simon Lin. “Molecular profile and partial functional analysis of novel endothelial cell-derived growth factors that regulate hematopoiesis.” Stem Cells 24, no. 5 (May 2006): 1315–27. https://doi.org/10.1634/stemcells.2005-0029.
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    • Lux, Andreas, Fiona Salway, Holly K. Dressman, Gabriele Kröner-Lux, Mathias Hafner, Philip J. R. Day, Douglas A. Marchuk, and John Garland. “ALK1 signalling analysis identifies angiogenesis related genes and reveals disparity between TGF-beta and constitutively active receptor induced gene expression.” Bmc Cardiovasc Disord 6 (April 4, 2006): 13. https://doi.org/10.1186/1471-2261-6-13.
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    • Damodaran, Tirupapuliyur V., Stephen T. Greenfield, Anand G. Patel, Holly K. Dressman, Siomon K. Lin, and Mohamed B. Abou-Donia. “Toxicogenomic studies of the rat brain at an early time point following acute sarin exposure.” Neurochem Res 31, no. 3 (March 2006): 367–81. https://doi.org/10.1007/s11064-005-9023-5.
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    • Potti, Anil, Andrea Bild, Holly K. Dressman, Deborah A. Lewis, Joseph R. Nevins, and Thomas L. Ortel. “Gene-expression patterns predict phenotypes of immune-mediated thrombosis.” Blood 107, no. 4 (February 15, 2006): 1391–96. https://doi.org/10.1182/blood-2005-07-2669.
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    • Damodaran, Tirupapuliyur V., Anand G. Patel, Stephen T. Greenfield, Holly K. Dressman, Simon M. Lin, and Mohamed B. Abou-Donia. “Gene expression profiles of the rat brain both immediately and 3 months following acute sarin exposure.” Biochem Pharmacol 71, no. 4 (February 14, 2006): 497–520. https://doi.org/10.1016/j.bcp.2005.10.051.
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    • Dressman, Holly K., Christopher Hans, Andrea Bild, John A. Olson, Eric Rosen, P Kelly Marcom, Vlayka B. Liotcheva, et al. “Gene expression profiles of multiple breast cancer phenotypes and response to neoadjuvant chemotherapy.” Clin Cancer Res 12, no. 3 Pt 1 (February 1, 2006): 819–26. https://doi.org/10.1158/1078-0432.CCR-05-1447.
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    • Bild, Andrea H., Guang Yao, Jeffrey T. Chang, Quanli Wang, Anil Potti, Dawn Chasse, Mary-Beth Joshi, et al. “Oncogenic pathway signatures in human cancers as a guide to targeted therapies.” Nature 439, no. 7074 (January 19, 2006): 353–57. https://doi.org/10.1038/nature04296.
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    • Dressman, Holly K., Lise Barley-Maloney, Laura-Leigh Rowlette, Paul F. Agris, and Mariano A. Garcia-Blanco. “Assessing incomplete deprotection of microarray oligonucleotides in situ.” Nucleic Acids Res 34, no. 19 (2006): e131. https://doi.org/10.1093/nar/gkl713.
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    • Boutlis, Craig S., Holly K. Dressman, Emiliana Tjitra, Helena Maniboey, Joseph R. Nevins, J Brice Weinberg, and Nicholas M. Anstey. “Patterns of gene expression that characterize outcomes of Plasmodium falciparum infection.” American Journal of Tropical Medicine and Hygiene 73, no. 6 (December 1, 2005): 225–225.
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    • Black, Esther P., Timothy Hallstrom, Holly K. Dressman, Mike West, and Joseph R. Nevins. “Distinctions in the specificity of E2F function revealed by gene expression signatures.” Proc Natl Acad Sci U S A 102, no. 44 (November 1, 2005): 15948–53. https://doi.org/10.1073/pnas.0504300102.
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    • Gollob, Jared A., Catherine J. Sciambi, Zhiqing Huang, and Holly K. Dressman. “Gene expression changes and signaling events associated with the direct antimelanoma effect of IFN-gamma.” Cancer Res 65, no. 19 (October 1, 2005): 8869–77. https://doi.org/10.1158/0008-5472.CAN-05-1387.
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    • Delong, Mark, Guang Yao, Quanli Wang, Adrian Dobra, Esther P. Black, Jeffrey T. Chang, Andrea Bild, Mike West, Joseph R. Nevins, and Holly Dressman. “DIG--a system for gene annotation and functional discovery.” Bioinformatics 21, no. 13 (July 1, 2005): 2957–59. https://doi.org/10.1093/bioinformatics/bti467.
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    • Martino, M. A., A. Elahi, R. Sutphen, C. Klippel, T. Boren, H. K. Dressman, A. Berchuck, and J. M. Lancaster. “Expression analysis of genes involved in ovarian cancer metastasis.” J Clin Oncol 23, no. 16_suppl (June 2005): 5038.
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    • Berchuck, Andrew, Edwin S. Iversen, Johnathan M. Lancaster, Jennifer Pittman, Jingqin Luo, Paula Lee, Susan Murphy, et al. “Patterns of gene expression that characterize long-term survival in advanced stage serous ovarian cancers.” Clin Cancer Res 11, no. 10 (May 15, 2005): 3686–96. https://doi.org/10.1158/1078-0432.CCR-04-2398.
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    • Rich, Jeremy N., Christopher Hans, Beatrix Jones, Edwin S. Iversen, Roger E. McLendon, BK Ahmed Rasheed, Adrian Dobra, et al. “Gene expression profiling and genetic markers in glioblastoma survival.” Cancer Res 65, no. 10 (May 15, 2005): 4051–58. https://doi.org/10.1158/0008-5472.CAN-04-3936.
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    • Bammler, Theodore, Richard P. Beyer, Sanchita Bhattacharya, Gary A. Boorman, Abee Boyles, Blair U. Bradford, Roger E. Bumgarner, et al. “Standardizing global gene expression analysis between laboratories and across platforms.” Nat Methods 2, no. 5 (May 2005): 351–56. https://doi.org/10.1038/nmeth754.
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    • Seo, David, Tao Wang, Holly Dressman, Edward E. Herderick, Edwin S. Iversen, Chunming Dong, Korkut Vata, et al. “Gene expression phenotypes of atherosclerosis.” Arterioscler Thromb Vasc Biol 24, no. 10 (October 2004): 1922–27. https://doi.org/10.1161/01.ATV.0000141358.65242.1f.
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    • Pittman, Jennifer, Erich Huang, Holly Dressman, Cheng-Fang Horng, Skye H. Cheng, Mei-Hua Tsou, Chii-Ming Chen, et al. “Integrated modeling of clinical and gene expression information for personalized prediction of disease outcomes.” Proc Natl Acad Sci U S A 101, no. 22 (June 1, 2004): 8431–36. https://doi.org/10.1073/pnas.0401736101.
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    • Berchuck, Andrew, Edwin S. Iversen, Johnathan M. Lancaster, Holly K. Dressman, Mike West, Joseph R. Nevins, and Jeffrey R. Marks. “Prediction of optimal versus suboptimal cytoreduction of advanced-stage serous ovarian cancer with the use of microarrays.” Am J Obstet Gynecol 190, no. 4 (April 2004): 910–25. https://doi.org/10.1016/j.ajog.2004.02.005.
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    • Advani, Anjali S., Holly K. Dressman, Marisol Quiroz, Gregory A. Taylor, and Ann Marie Pendergast. “Elevated expression of a subset of interferon inducible genes in primary bone marrow cells expressing p185 Bcr-Abl versus p210 Bcr-Abl by DNA microarray analysis.” Leuk Res 28, no. 3 (March 2004): 285–94. https://doi.org/10.1016/s0145-2126(03)00264-9.
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    • Hashimoto, Tomoki, Michael T. Lawton, Gen Wen, Guo-Yuan Yang, Thomas Chaly, Campbell L. Stewart, Holly K. Dressman, Nicholas M. Barbaro, Douglas A. Marchuk, and William L. Young. “Gene microarray analysis of human brain arteriovenous malformations.” Neurosurgery 54, no. 2 (February 2004): 410–23. https://doi.org/10.1227/01.neu.0000103421.35266.71.
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    • Lancaster, Johnathan M., Holly K. Dressman, Regina S. Whitaker, Laura Havrilesky, Jonathan Gray, Jeffrey R. Marks, Joseph R. Nevins, and Andrew Berchuck. “Gene expression patterns that characterize advanced stage serous ovarian cancers.” J Soc Gynecol Investig 11, no. 1 (January 2004): 51–59. https://doi.org/10.1016/j.jsgi.2003.07.004.
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    • Qin, Li-Xuan, Kathleen F. Kerr, and Kathleen F. Contributing Members of the Toxicogenomics Research Consortium. “Empirical evaluation of data transformations and ranking statistics for microarray analysis.” Nucleic Acids Res 32, no. 18 (2004): 5471–79. https://doi.org/10.1093/nar/gkh866.
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    • Nevins, Joseph R., Erich S. Huang, Holly Dressman, Jennifer Pittman, Andrew T. Huang, and Mike West. “Towards integrated clinico-genomic models for personalized medicine: combining gene expression signatures and clinical factors in breast cancer outcomes prediction.” Hum Mol Genet 12 Spec No 2 (October 15, 2003): R153–57. https://doi.org/10.1093/hmg/ddg287.
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    • Ellis, Matthew J., Eric Rosen, Holly Dressman, and Jeffery Marks. “Neoadjuvant comparisons of aromatase inhibitors and tamoxifen: pretreatment determinants of response and on-treatment effect.” J Steroid Biochem Mol Biol 86, no. 3–5 (September 2003): 301–7. https://doi.org/10.1016/s0960-0760(03)00371-6.
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    • Huang, Erich S., Esther P. Black, Holly Dressman, Mike West, and Joseph R. Nevins. “Gene expression phenotypes of oncogenic signaling pathways.” Cell Cycle 2, no. 5 (September 2003): 415–17.
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    • Huang, E., S. Ishida, J. Pittmann, H. Dressman, A. Bild, M. Kloos, M. D’Amico, R. G. Pestell, M. West, and J. R. Nevins. “Erratum: Gene expression phenotypic models that predict the activity of oncogenic pathways (Nature Genetics (2003) 34 (226-230)).” Nature Genetics 34, no. 4 (August 1, 2003): 465. https://doi.org/10.1038/ng0803-465.
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    • Black, Esther P., Erich Huang, Holly Dressman, Rachel Rempel, Nina Laakso, Sylvia L. Asa, Seiichi Ishida, Mike West, and Joseph R. Nevins. “Distinct gene expression phenotypes of cells lacking Rb and Rb family members.” Cancer Res 63, no. 13 (July 1, 2003): 3716–23.
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    • Huang, Erich, Seiichi Ishida, Jennifer Pittman, Holly Dressman, Andrea Bild, Mark Kloos, Mark D’Amico, Richard G. Pestell, Mike West, and Joseph R. Nevins. “Gene expression phenotypic models that predict the activity of oncogenic pathways.” Nat Genet 34, no. 2 (June 2003): 226–30. https://doi.org/10.1038/ng1167.
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    • Huang, Erich, Skye H. Cheng, Holly Dressman, Jennifer Pittman, Mei Hua Tsou, Cheng Fang Horng, Andrea Bild, et al. “Gene expression predictors of breast cancer outcomes.” Lancet 361, no. 9369 (May 10, 2003): 1590–96. https://doi.org/10.1016/S0140-6736(03)13308-9.
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    • Bebenek, Anna, Geraldine T. Carver, Holly Kloos Dressman, Farid A. Kadyrov, Joseph K. Haseman, Vasiliy Petrov, William H. Konigsberg, Jim D. Karam, and John W. Drake. “Dissecting the fidelity of bacteriophage RB69 DNA polymerase: site-specific modulation of fidelity by polymerase accessory proteins.” Genetics 162, no. 3 (November 2002): 1003–18.
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    • West, M., C. Blanchette, H. Dressman, E. Huang, S. Ishida, R. Spang, H. Zuzan, J. A. Olson, J. R. Marks, and J. R. Nevins. “Predicting the clinical status of human breast cancer by using gene expression profiles.” Proc Natl Acad Sci U S A 98, no. 20 (September 25, 2001): 11462–67. https://doi.org/10.1073/pnas.201162998.
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    • Bebenek, A., H. K. Dressman, G. T. Carver, S. Ng, V. Petrov, G. Yang, W. H. Konigsberg, J. D. Karam, and J. W. Drake. “Interacting fidelity defects in the replicative DNA polymerase of bacteriophage RB69.” J Biol Chem 276, no. 13 (March 30, 2001): 10387–97. https://doi.org/10.1074/jbc.M007707200.
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    • Dressman, H. K., and J. W. Drake. “Lysis and lysis inhibition in bacteriophage T4: rV mutations reside in the holin t gene.” J Bacteriol 181, no. 14 (July 1999): 4391–96. https://doi.org/10.1128/JB.181.14.4391-4396.1999.
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    • Paddison, P., S. T. Abedon, H. K. Dressman, K. Gailbreath, J. Tracy, E. Mosser, J. Neitzel, B. Guttman, and E. Kutter. “The roles of the bacteriophage T4 r genes in lysis inhibition and fine-structure genetics: a new perspective.” Genetics 148, no. 4 (April 1998): 1539–50.
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    • Dressman, H. K., C. C. Wang, J. D. Karam, and J. W. Drake. “Retention of replication fidelity by a DNA polymerase functioning in a distantly related environment.” Proc Natl Acad Sci U S A 94, no. 15 (July 22, 1997): 8042–46. https://doi.org/10.1073/pnas.94.15.8042.
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    • Humphries, J. E., H. K. Dressman, and M. E. Williams. “Immunoglobulin gene rearrangement in multiple myeloma: limitations of Southern blot analysis.” Hum Pathol 22, no. 10 (October 1991): 966–71. https://doi.org/10.1016/0046-8177(91)90004-9.
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  • Other Articles

    • “Retraction. An integrated genomic-based approach to individualized treatment of patients with advanced-stage ovarian cancer.” J Clin Oncol, February 20, 2012. https://doi.org/10.1200/jco.2012.42.0331.
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    • “Retraction. Pharmacogenomic strategies provide a rational approach to the treatment of cisplatin-resistant patients with advanced cancer. J Clin Oncol 25:4350–7, 2007.” J Clin Oncol, December 10, 2010. https://doi.org/10.1200/JCO.2010.33.7311.
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    • Andrew, B., E. S. Iversen, J. M. Lancaster, H. K. Dressman, M. West, J. R. Nevins, J. R. Marks, and B. E. Miller. “Prediction of optimal versus suboptimal cytoreduction of advanced-stage serious ovarian cancer with the use of microarrays.” Women’S Oncology Review, September 1, 2004. https://doi.org/10.1080/14733400412331312585.
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  • Conference Papers

    • Danko, Melissa E., Brian R. Untch, Christopher L. Tebbit, Jun Zhai, Holly K. Dressman, Rex C. Bentley, Jay Baker, Jeffley R. Marks, Joseph R. Nevins, and Olson John A. Jr. “A clinicogenomic model to predict lymph node metastasis in breast cancer.” In Journal of the American College of Surgeons, 207:S45–S45, 2008. https://doi.org/10.1016/j.jamcollsurg.2008.06.092.
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    • Gallagher, Patrick G., Andre M. Pilon, Murat O. Arcasoy, Serena E. Vayda, Holly K. Dressman, James J. Bieker, and David M. Bodine. “Failure of definitive erythropoiesis in EKLF-deficient mice.” In Blood Cells, Molecules, and Diseases, 38:140–41. Elsevier BV, 2007. https://doi.org/10.1016/j.bcmd.2006.10.050.
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    • Pilon, Andre M., Murat O. Arcasoy, Serena E. Vayda, Holly K. Dressman, James J. Bieker, David M. Bodine, and Patrick G. Gallagher. “EKLF-deficiency leads to multiple defects in erythropoiesis: Dysregulation of AHSP and E2F.” In Blood Cells, Molecules, and Diseases, 38:172–172. Elsevier BV, 2007. https://doi.org/10.1016/j.bcmd.2006.10.118.
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    • Pilon, Andre M., Murat O. Arcasoy, Serena E. Vayda, Holly K. Dressman, James J. Bieker, David M. Bodine, and Patrick G. Gallagher. “Defects in E2F1/2 expression are associated with abnormalities in cell cycle and differentiation in EKLF-deficient erythroid cells.” In Blood, 108:29A-29A. AMER SOC HEMATOLOGY, 2006.
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    • Potti, A., H. K. Dressman, A. Bild, R. Riedel, M. Kelley, G. Ginsburg, J. Lancaster, J. Nevins, and P. Febbo. “A genomic strategy to combinatorial therapeutics in solid tumors.” In Journal of Clinical Oncology, 24:86S-86S. AMER SOC CLINICAL ONCOLOGY, 2006.
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    • Dressman, Holly K., Johnathan M. Lancaster, Gina Chan, Janiel M. Cragun, Andrea Bild, Robyn Sayer, Jennifer Clarke, et al. “Targeted approaches to the treatment of ovarian cancer.” In Cancer Research, Vol. 66. AMER ASSOC CANCER RESEARCH, 2006.
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    • Potti, A., H. K. Dressman, A. H. Bild, J. R. Nevins, and P. K. Marcom. “Gene expression-based signatures of chemosensitivity and oncogenic pathway deregulation provide a novel approach to breast cancer therapeutics.” In Breast Cancer Research and Treatment, 100:S278–S278. SPRINGER, 2006.
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    • Gallagher, P. G., M. O. Arcasoy, S. E. Vayda, H. K. Dressman, J. J. Bieker, and D. M. Bodine. “A differentiation block in erythroid cells lacking erythroid krupple-like factor (EKLF).” In Blood, 106:157A-157A. AMER SOC HEMATOLOGY, 2005.
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    • Potti, A., H. K. Dressman, and M. O. Arcasoy. “Gene expression patterns identify novel biologically relevant signaling and transcriptional pathways involved in terminal erythroid differentiation and polycythemia vera.” In Blood, 106:984A-984A. AMER SOC HEMATOLOGY, 2005.
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    • Bild, A. H., G. Yao, J. T. Chang, Q. L. Wang, A. Potti, D. Harpole, J. Lancaster, et al. “Oncogenic pathway signatures in human cancers as a guide to targeted therapies.” In Cancer Epidemiology Biomarkers & Prevention, 14:2743S-2743S. AMER ASSOC CANCER RESEARCH, 2005.
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    • Martino, M. A., A. Elahi, R. Sutphen, C. Klippel, T. Boren, H. K. Dressman, A. Berchuck, and J. M. Lancaster. “Expression analysis of genes involved in ovarian cancer metastasis.” In Journal of Clinical Oncology, 23:464S-464S. AMER SOC CLINICAL ONCOLOGY, 2005.
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    • Burch, L. H., I. V. Yang, H. K. Dressman, D. A. Schwartz, H. Guo, P. C. Kuo, H. J. Cohen, and S. A. Lagoo-Deenadayalan. “Transcriptional response to endotoxin in young adult and aged rats.” In Journal of the American Geriatrics Society, 53:S70–S70. WILEY-BLACKWELL, 2005.
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    • Blackwell, K. L., H. Dressman, J. Olson, E. Rosen, P. K. Marcom, V. Liotcheva, E. Jones, et al. “Molecular signatures that predict response to anthracycline-taxane based neoadjuvant chemotherapy.” In Breast Cancer Research and Treatment, 88:S22–S22. SPRINGER, 2004.
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    • Pittman, J. L., C. L. Tebbit, E. P. Black, H. K. Dressman, E. S. Huang, J. A. Olson, J. R. Marks, et al. “Predictive models that combine multiple forms of genomic and clinical data to achieve personalized prediction of outcomes in breast cancer.” In Breast Cancer Research and Treatment, 88:S21–22. SPRINGER, 2004.
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    • Advani, A. S., H. K. Dressman, M. Quiroz, G. A. Taylor, and A. M. Pendergast. “Elevated expression of numerous interferon inducible genes in primary bone marrow cells expressing p185 Bcr-Abl versus p210 Bcr-Abl by DNA microarray analysis.” In Blood, 100:584A-584A. AMER SOC HEMATOLOGY, 2002.
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  • Datasets

    • Shen, Xiling, Shengli Ding, Holly Dressman, Anders B. Dohlman, Michael Gao, Diana Arguijo-Mendoza, Steven M. Lipkin, and Iliyan D. Iliev. “Data from: The Cancer Microbiome Atlas (TCMA): A Pan-Cancer Comparative Analysis to Distinguish Organ-Associated Microbiota from Equiprevalent Contaminants,” September 29, 2020. https://doi.org/10.7924/r4rn36833.
       Data Access

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