Yuh-Chin Tony Huang

Journal article eLife · October 15, 2014 Featured Publication To identify new approaches to enhance innate immunity to bacterial pneumonia, we investigated the natural experiment of gender differences in resistance to infections. Female and estrogen-treated male mice show greater resistance to pneumococcal pn ... Full text Cite

Comparison of gene expression profiles induced by coarse, fine, and ultrafine particulate matter.

Journal article J Toxicol Environ Health A · 2011 Featured Publication Coarse, fine, and ultrafine particulate matter (PM) fractions possess different physical properties and chemical compositions and may produce different adverse health effects. Studies were undertaken to determine whether or not gene expression patterns may ... Full text Link to item Cite

Gene expression profile in circulating mononuclear cells after exposure to ultrafine carbon particles.

Journal article Inhal Toxicol · August 2010 Featured Publication CONTEXT: Exposure to particulate matter (PM) is associated with systemic health effects, but the cellular and molecular mechanisms are unclear. OBJECTIVE: We hypothesized that, if circulating mononuclear cells play an important role in mediating systemic e ... Full text Link to item Cite

Correlation between the %MinVol setting and work of breathing during adaptive support ventilation in patients with respiratory failure.

Journal article Respir Care · March 2010 Featured Publication BACKGROUND: Adaptive support ventilation (ASV) is a new mode of mechanical ventilation that seeks an optimal breathing pattern based on the minimum work of breathing (WOB) principle. The operator's manual for the ventilators that provide ASV recommends tha ... Link to item Cite

Fine ambient particles induce oxidative stress and metal binding genes in human alveolar macrophages.

Journal article Am J Respir Cell Mol Biol · November 2009 Featured Publication Exposure to pollutant particles increased respiratory morbidity and mortality. The alveolar macrophages (AMs) are one cell type in the lung directly exposed to particles. Upon contact with particles, AMs are activated and produce reactive oxygen species, b ... Full text Link to item Cite

Controlled human exposures to ambient pollutant particles in susceptible populations.

Journal article Environ Health · July 25, 2009 Featured Publication Epidemiologic studies have established an association between exposures to air pollution particles and human mortality and morbidity at concentrations of particles currently found in major metropolitan areas. The adverse effects of pollution particles are ... Full text Open Access Link to item Cite

Exposure to concentrated coarse air pollution particles causes mild cardiopulmonary effects in healthy young adults.

Journal article Environ Health Perspect · July 2009 Featured Publication BACKGROUND: There is ample epidemiologic and toxicologic evidence that exposure to fine particulate matter (PM) air pollution [aerodynamic diameter < or = 2.5 microm (PM(2.5))], which derives primarily from combustion processes, can result in increased mor ... Full text Open Access Link to item Cite

Concentrated ambient ultrafine particle exposure induces cardiac changes in young healthy volunteers.

Journal article Am J Respir Crit Care Med · June 1, 2009 Featured Publication RATIONALE: Exposure to ambient ultrafine particles has been associated with cardiopulmonary toxicity and mortality. Adverse effects specifically linked to ultrafine particles include loss of sympathovagal balance and altered hemostasis. OBJECTIVES: To char ... Full text Link to item Cite

Identification of gene biomarkers for respiratory syncytial virus infection in a bronchial epithelial cell line.

Journal article Genomic Med · December 2008 Featured Publication Respiratory syncytial virus (RSV) infection involves complex virus-host interplay. In this study, we analyzed gene expression in RSV-infected BEAS-2B cells to discover novel signaling pathways and biomarkers. We hybridized RNAs from RSV- or vehicle-treated ... Full text Link to item Cite

Changes in B-type natriuretic peptide improve weaning outcome predicted by spontaneous breathing trial.

Journal article Crit Care Med · May 2008 Featured Publication OBJECTIVE: Despite the use of spontaneous breathing trial (SBT), predicting weaning success remains a major clinical challenge. Because cardiovascular dysfunction could be a major underlying mechanism of weaning failure, we evaluated the role of the levels ... Full text Link to item Cite

Acute exacerbations and respiratory failure in chronic obstructive pulmonary disease.

Journal article Proc Am Thorac Soc · May 1, 2008 Featured Publication Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) describe the phenomenon of sudden worsening in airway function and respiratory symptoms in patients with COPD. These exacerbations can range from self-limited diseases to episodes of flo ... Full text Link to item Cite

Lung compliance measurement in mice.

Journal article Am J Physiol Lung Cell Mol Physiol · April 2008 Featured Publication Full text Link to item Cite

Patient-ventilator synchrony during pressure-targeted versus flow-targeted small tidal volume assisted ventilation.

Journal article J Crit Care · September 2007 Featured Publication PURPOSE: Low tidal volume (V(T)) delivered by flow-targeted breaths reduces ventilator-induced lung injury but may increase patient breathing effort because of limited flow. We hypothesized that a variable-flow, pressure-targeted breath would improve breat ... Full text Link to item Cite

Up-regulation of tissue factor in human pulmonary artery endothelial cells after ultrafine particle exposure.

Journal article Environ Health Perspect · April 2007 Featured Publication BACKGROUND: Epidemiology studies have linked exposure to pollutant particles to increased cardiovascular mortality and morbidity, but the mechanisms remain unknown. OBJECTIVES: We tested the hypothesis that the ultrafine fraction of ambient pollutant parti ... Full text Open Access Link to item Cite

Pollutant particles enhanced H2O2 production from NAD(P)H oxidase and mitochondria in human pulmonary artery endothelial cells.

Journal article Am J Physiol Cell Physiol · August 2006 Featured Publication Particulate matter (PM) induces oxidative stress and cardiovascular adverse health effects, but the mechanistic link between the two is unclear. We hypothesized that PM enhanced oxidative stress in vascular endothelial cells and investigated the enzymatic ... Full text Link to item Cite

Vascular effects of ambient pollutant particles and metals.

Journal article Curr Vasc Pharmacol · July 2006 Featured Publication Exposure to ambient pollutant particle (APP) is associated with increased cardiovascular morbidity and mortality. Recent evidence indicates that APP-induced vasoconstriction may be an important mechanism. APP constricts systemic arteries and increases bloo ... Full text Link to item Cite

Acute phase reaction in healthy volunteers after bronchoscopy with lavage.

Journal article Chest · June 2006 Featured Publication STUDY OBJECTIVES: Bronchoscopy with BAL is being used increasingly in the investigation of acute and chronic lung inflammation. The scope of the acute phase response induced by the procedure is not fully evaluated. The purpose of the study is to characteri ... Full text Link to item Cite

Discrimination of vanadium from zinc using gene profiling in human bronchial epithelial cells.

Journal article Environ Health Perspect · December 2005 Featured Publication We hypothesized that gene expression profiling may discriminate vanadium from zinc in human bronchial epithelial cells (HBECs). RNA from HBECs exposed to vehicle, V (50 microM), or Zn (50 microM) for 4 hr (n = 4 paired experiments) was hybridized to Affyme ... Full text Open Access Link to item Cite

MARCO is the major binding receptor for unopsonized particles and bacteria on human alveolar macrophages.

Journal article J Immunol · November 1, 2005 Featured Publication Alveolar macrophages (AMs) avidly bind and ingest inhaled environmental particles and bacteria. To identify the particle binding receptor(s) on human AMs, we used functional screening of anti-human AM hybridomas and isolated a mAb, PLK-1, which inhibits AM ... Full text Link to item Cite

Monitoring oxygen delivery in the critically ill.

Journal article Chest · November 2005 Featured Publication An accurate assessment of regional tissue oxygen delivery (DO(2)) may help the intensivist to attenuate end-organ damage in critically ill patients. Transport of oxygen from the ambient air to the mitochondria occurs by convection and diffusion, and is tig ... Full text Link to item Cite

A nitric oxide processing defect of red blood cells created by hypoxia: deficiency of S-nitrosohemoglobin in pulmonary hypertension.

Journal article Proc Natl Acad Sci U S A · October 11, 2005 Featured Publication The mechanism by which hypoxia [low partial pressure of O(2) (pO(2))] elicits signaling to regulate pulmonary arterial pressure is incompletely understood. We considered the possibility that, in addition to its effects on smooth muscle, hypoxia may influen ... Full text Link to item Cite

Beneficial effects of albuterol therapy driven by heliox versus by oxygen in severe asthma exacerbation.

Journal article Acad Emerg Med · September 2005 Featured Publication OBJECTIVES: To determine and define the beneficial effects of heliox-driven albuterol therapy on severe asthma exacerbation and clinical factors that affect greater response. METHODS: The authors conducted two randomized, double-blinded, controlled trials ... Full text Link to item Cite

Pollutant particles produce vasoconstriction and enhance MAPK signaling via angiotensin type I receptor.

Journal article Environ Health Perspect · August 2005 Featured Publication Exposure to particulate matter (PM) is associated with acute cardiovascular mortality and morbidity, but the mechanisms are not entirely clear. In this study, we hypothesized that PM may activate the angiotensin type 1 receptor (AT1R), a G protein-coupled ... Full text Open Access Link to item Cite

Seasonal variations in air pollution particle-induced inflammatory mediator release and oxidative stress.

Journal article Environ Health Perspect · August 2005 Featured Publication Health effects associated with particulate matter (PM) show seasonal variations. We hypothesized that these heterogeneous effects may be attributed partly to the differences in the elemental composition of PM. Normal human bronchial epithelial (NHBE) cells ... Full text Open Access Link to item Cite

3-nitrotyrosine attenuates respiratory syncytial virus infection in human bronchial epithelial cell line.

Journal article Am J Physiol Lung Cell Mol Physiol · May 2005 Featured Publication 3-nitrotyrosine (NO2Tyr), an L-tyrosine derivative during nitrative stress, can substitute the COOH-terminal tyrosine of alpha-tubulin, posttranslationally altering microtubular functions. Because infection of the cells by respiratory syncytial virus (RSV) ... Full text Link to item Cite

Heliox improves hemodynamics in mechanically ventilated patients with chronic obstructive pulmonary disease with systolic pressure variations.

Journal article Crit Care Med · May 2005 Featured Publication OBJECTIVE: To test the hypothesis that, compared with air-oxygen, heliox would improve cardiac performance in mechanically ventilated patients with severe chronic obstructive pulmonary disease and systolic pressure variations >15 mm Hg and to determine cli ... Full text Link to item Cite

Apoptotic and inflammatory effects induced by different particles in human alveolar macrophages.

Journal article Inhal Toxicol · December 15, 2004 Featured Publication Pollutant particles induce apoptosis and inflammation, but the relationship between these two biological processes is not entirely clear. In this study, we compared the proapoptotic and proinflammatory effects of four particles: residual oil fly ash (ROFA) ... Full text Link to item Cite

Reduced inspiratory flow attenuates IL-8 release and MAPK activation of lung overstretch.

Journal article Eur Respir J · August 2004 Featured Publication Lung overstretch involves mechanical factors, including large tidal volumes (VT), which induce inflammatory responses. The current authors hypothesised that inspiratory flow contributes to ventilator-induced inflammation. Buffer-perfused rabbit lungs were ... Full text Link to item Cite

Vanadyl sulfate inhibits NO production via threonine phosphorylation of eNOS.

Journal article Environ Health Perspect · February 2004 Featured Publication Exposure to excessive vanadium occurs in some occupations and with consumption of some dietary regimens for weight reduction and body building. Because vanadium is vasoactive, individuals exposed to excessive vanadium may develop adverse vascular effects. ... Full text Open Access Link to item Cite

Neutrophil depletion attenuates interleukin-8 production in mild-overstretch ventilated normal rabbit lung.

Journal article Crit Care Med · February 2004 Featured Publication OBJECTIVE: Acute lung injury induced by lung overstretch is associated with neutrophil influx, but the pathogenic role of neutrophils in overstretch-induced lung injury remains unclear. DESIGN: To assess the contribution of neutrophils, we compared the eff ... Full text Link to item Cite

Exposure to concentrated ambient particles (CAPs): a review.

Journal article Inhal Toxicol · January 2004 Featured Publication Epidemiologic studies support a participation of fine particulate matter (PM) with a diameter of 0.1 to 2.5 microm in the effects of air pollution particles on human health. The ambient fine particle concentrator is a recently developed technology that can ... Full text Link to item Cite

The role of soluble components in ambient fine particles-induced changes in human lungs and blood.

Journal article Inhal Toxicol · April 11, 2003 Featured Publication Normal individuals developed pulmonary neutrophilic inflammation and increased blood fibrinogen following inhalation of concentrated ambient particles (CAPS). In this study, we sought to determine how soluble components in CAPS contributed to these changes ... Full text Link to item Cite

Mitochondrial oxidant production by a pollutant dust and NO-mediated apoptosis in human alveolar macrophage.

Journal article Am J Physiol Cell Physiol · January 2003 Featured Publication Residual oil fly ash (ROFA) is a pollutant dust that stimulates production of reactive oxygen species (ROS) from mitochondria and apoptosis in alveolar macrophages (AM), but the relationship between these two processes is unclear. In this study, human AM w ... Full text Link to item Cite