Scholars@Duke
Huanghe Yang

Huanghe Yang

Associate Professor of Biochemistry
Biochemistry
Box 3711,DUMC, Durham, NC 27710
213 Nanaline H Duke, Box 3711, DUMC, Durham, NC 27710

Scholarly Works - Preprints

Cannabidiol Inhibits PIEZO Channels to Mitigate Red Blood Disorders

Preprint · 2026 Hyperactivity of the mechanosensitive ion channel PIEZO1 promotes pathologic Ca²⁺ overload in red blood cells (RBCs), driving dehydration, TMEM16F-dependent phosphatidylserine (PS) exposure, microparticle shedding, and increased thrombotic and vaso-occlusi ... Full text Cite

Gardos potassium channel amplifies PIEZO1-TMEM16F coupling in red blood cells

Preprint · 2026 ABSTRACT In red blood cells (RBCs), the mechanosensitive channel PIEZO1 provides an upstream Ca 2+ signal that activates TMEM16F, a Ca 2+ -activated phospholipid scramblase (CaPLSase) responsible for phosphatidylserine (PS) externalization. How ... Full text Cite

TMEM16 and OSCA/TMEM63 proteins share a conserved potential to permeate ions and phospholipids.

Preprint · November 4, 2024 The calcium-activated TMEM16 proteins and the mechanosensitive/osmolarity-activated OSCA/TMEM63 proteins belong to the Transmembrane Channel/Scramblase (TCS) superfamily. Within the superfamily, OSCA/TMEM63 proteins, as well as TMEM16A and TMEM16B, are tho ... Full text Link to item Cite

TMEM16 and OSCA/TMEM63 proteins share a conserved potential to permeate ions and phospholipids

Preprint · October 16, 2024 AbstractThe calcium-activated TMEM16 proteins and the mechanosensitive/osmolarity-activated OSCA/TMEM63 proteins belong to the Transmembrane Channel/Scramblase (TCS) superfamily. Within the superfamily, OSCA/TMEM63 ... Full text Cite

TMEM16 and TMEM63/OSCA proteins share a conserved potential to permeate ions and phospholipids

Preprint · May 1, 2024 AbstractThe calcium-activated TMEM16 proteins and the mechanosensitive/osmolarity-activated OSCA/TMEM63 proteins belong to the Transmembrane Channel/Scramblase (TCS) superfamily. Within the superfamily, OSCA/TMEM63 ... Full text Cite

Niclosamide potentiates TMEM16A and induces vasoconstriction.

Preprint · August 2, 2023 The TMEM16A calcium-activated chloride channel is a promising therapeutic target for various diseases. Niclosamide, an anthelmintic medication, has been considered as a TMEM16A inhibitor for treating asthma and chronic obstructive pulmonary disease, but wa ... Full text Link to item Cite

Trophoblast organoids with physiological polarity model placental structure and function.

Preprint · July 17, 2023 Human trophoblast organoids (TOs) are a three-dimensional ex vivo culture model that can be used to study various aspects of placental development, physiology, and pathology. Previously, we showed that TOs derived from full-term human placental tissue coul ... Full text Link to item Cite