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Hui Chen

Associate Professor of Medicine
Medicine, Medical Oncology

Selected Publications


Novel agents and regimens in acute myeloid leukemia: latest updates from 2022 ASH Annual Meeting.

Journal Article J Hematol Oncol · March 3, 2023 Developments in investigational agents and novel regimens in acute myeloid leukemia (AML) were reported in the 2022 American Society of Hematology (ASH) annual meeting. Encouraging efficacy data were presented from first-in-human studies of two investigati ... Full text Link to item Cite

Quantification of IGF-1 receptor is useful in the differential diagnosis of essential thrombocytosis from reactive thrombocytosis.

Journal Article Eur J Haematol · December 2019 BACKGROUND: To make a definite diagnosis of essential thrombocytosis (ET) from reactive thrombocytosis (RT), the most reliable criteria are the presence of driver mutations, namely JAK2, CALR, or MPL gene mutations. In the absence of these driver mutations ... Full text Link to item Cite

Quantification of IGF-1 Receptor May Be Useful in Diagnosing Polycythemia Vera-Suggestion to Be Added to Be One of the Minor Criterion.

Journal Article PLoS One · 2016 Endogenous erythroid colony (EEC) formation is one of the minor criteria for diagnosing polycythemia vera (PV) according to 2008 WHO diagnostic criteria. But EEC requires bone marrow aspiration and sophisticated laboratory procedures; therefore, practicall ... Full text Link to item Cite

Visualization of the Interstitial Cells of Cajal (ICC) Network in Mice

Journal Article Journal of Visualized Experiments · July 27, 2011 Full text Cite

Regulation of SRF/CArG‐dependent gene transcription during chronic partial obstruction of murine small intestine

Journal Article Neurogastroenterology & Motility · July 2008 Abstract  Intestinal obstructions lead to a variety of motility disorders. Small intestine smooth muscles undergo dramatic phenotypic changes in response to obstruction, but the underlying molecular mechanisms are unknown. Us ... Full text Cite

Differential gene expression in functional classes of interstitial cells of Cajal in murine small intestine

Journal Article Physiological Genomics · November 2007 Interstitial cells of Cajal (ICC) have important functions in regulation of motor activity in the gastrointestinal tract. In murine small intestine, ICC are gathered in the regions of the myenteric plexus (ICC-MY) and the deep muscular plexus (ICC- ... Full text Cite

β-Nicotinamide adenine dinucleotide is an inhibitory neurotransmitter in visceral smooth muscle

Journal Article Proceedings of the National Academy of Sciences · October 9, 2007 Peripheral inhibitory nerves are physiological regulators of the contractile behavior of visceral smooth muscles. One of the transmitters responsible for inhibitory neurotransmission has been reputed to be a purine, possibly ATP. However, the exact ... Full text Cite

Selective labeling and isolation of functional classes of interstitial cells of Cajal of human and murine small intestine

Journal Article American Journal of Physiology-Cell Physiology · January 2007 Specific functions of interstitial cells of Cajal (ICC) have been linked to distinct classes that differ by morphology and distribution. In the small intestine, slow wave-generating ICC are located in the myenteric region (ICC-MY), whereas ICC tha ... Full text Cite

13
Role of local progenitors in the sustenance of networks of interstitial cells of Cajal (ICC) in the murine stomach

Journal Article Neurogastroenterology & Motility · June 2006 Depletion of ICC networks and consequent changes in electrical slow wave activity and neuromuscular neurotransmission play important roles in diabetic and idiopathic gastroparesis. We have shown that reduced insulin/IGF‐I signaling and consequent d ... Full text Cite

Imatinib inhibits various types of activating mutant kit found in gastrointestinal stromal tumors

Journal Article International Journal of Cancer · May 20, 2003 AbstractMutations of proto‐oncogene c‐KIT in gastrointestinal stromal tumors (GISTs) are considered to cause a constitutive activation of KIT responsible for their oncogenesis. Imatinib has therapeutic potential for GISTs b ... Full text Cite

c‐kit Gene mutation at exon 17 or 13 is very rare in sporadic gastrointestinal stromal tumors

Journal Article Journal of Gastroenterology and Hepatology · February 2003 AbstractBackground and Aim:  Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the human gut. They frequently have gain‐of‐function mutations of the c‐kit gene, which en ... Full text Cite

Deficiency of KIT‐positive cells in the colon of patients with diabetes mellitus

Journal Article Journal of Gastroenterology and Hepatology · June 2002 AbstractBackgroundDiabetes mellitus is a well‐known cause of gastrointestinal dysmotility. The pathogenesis of diabetic gastroenteropathy is mainly considered to be a ... Full text Cite

Novel agents and regimens in acute myeloid leukemia: latest updates from 2022 ASH Annual Meeting.

Journal Article J Hematol Oncol · March 3, 2023 Developments in investigational agents and novel regimens in acute myeloid leukemia (AML) were reported in the 2022 American Society of Hematology (ASH) annual meeting. Encouraging efficacy data were presented from first-in-human studies of two investigati ... Full text Link to item Cite

Quantification of IGF-1 receptor is useful in the differential diagnosis of essential thrombocytosis from reactive thrombocytosis.

Journal Article Eur J Haematol · December 2019 BACKGROUND: To make a definite diagnosis of essential thrombocytosis (ET) from reactive thrombocytosis (RT), the most reliable criteria are the presence of driver mutations, namely JAK2, CALR, or MPL gene mutations. In the absence of these driver mutations ... Full text Link to item Cite

Quantification of IGF-1 Receptor May Be Useful in Diagnosing Polycythemia Vera-Suggestion to Be Added to Be One of the Minor Criterion.

Journal Article PLoS One · 2016 Endogenous erythroid colony (EEC) formation is one of the minor criteria for diagnosing polycythemia vera (PV) according to 2008 WHO diagnostic criteria. But EEC requires bone marrow aspiration and sophisticated laboratory procedures; therefore, practicall ... Full text Link to item Cite

Visualization of the Interstitial Cells of Cajal (ICC) Network in Mice

Journal Article Journal of Visualized Experiments · July 27, 2011 Full text Cite

Regulation of SRF/CArG‐dependent gene transcription during chronic partial obstruction of murine small intestine

Journal Article Neurogastroenterology & Motility · July 2008 Abstract  Intestinal obstructions lead to a variety of motility disorders. Small intestine smooth muscles undergo dramatic phenotypic changes in response to obstruction, but the underlying molecular mechanisms are unknown. Us ... Full text Cite

Differential gene expression in functional classes of interstitial cells of Cajal in murine small intestine

Journal Article Physiological Genomics · November 2007 Interstitial cells of Cajal (ICC) have important functions in regulation of motor activity in the gastrointestinal tract. In murine small intestine, ICC are gathered in the regions of the myenteric plexus (ICC-MY) and the deep muscular plexus (ICC- ... Full text Cite

β-Nicotinamide adenine dinucleotide is an inhibitory neurotransmitter in visceral smooth muscle

Journal Article Proceedings of the National Academy of Sciences · October 9, 2007 Peripheral inhibitory nerves are physiological regulators of the contractile behavior of visceral smooth muscles. One of the transmitters responsible for inhibitory neurotransmission has been reputed to be a purine, possibly ATP. However, the exact ... Full text Cite

Selective labeling and isolation of functional classes of interstitial cells of Cajal of human and murine small intestine

Journal Article American Journal of Physiology-Cell Physiology · January 2007 Specific functions of interstitial cells of Cajal (ICC) have been linked to distinct classes that differ by morphology and distribution. In the small intestine, slow wave-generating ICC are located in the myenteric region (ICC-MY), whereas ICC tha ... Full text Cite

13
Role of local progenitors in the sustenance of networks of interstitial cells of Cajal (ICC) in the murine stomach

Journal Article Neurogastroenterology & Motility · June 2006 Depletion of ICC networks and consequent changes in electrical slow wave activity and neuromuscular neurotransmission play important roles in diabetic and idiopathic gastroparesis. We have shown that reduced insulin/IGF‐I signaling and consequent d ... Full text Cite

Imatinib inhibits various types of activating mutant kit found in gastrointestinal stromal tumors

Journal Article International Journal of Cancer · May 20, 2003 AbstractMutations of proto‐oncogene c‐KIT in gastrointestinal stromal tumors (GISTs) are considered to cause a constitutive activation of KIT responsible for their oncogenesis. Imatinib has therapeutic potential for GISTs b ... Full text Cite

c‐kit Gene mutation at exon 17 or 13 is very rare in sporadic gastrointestinal stromal tumors

Journal Article Journal of Gastroenterology and Hepatology · February 2003 AbstractBackground and Aim:  Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the human gut. They frequently have gain‐of‐function mutations of the c‐kit gene, which en ... Full text Cite

Deficiency of KIT‐positive cells in the colon of patients with diabetes mellitus

Journal Article Journal of Gastroenterology and Hepatology · June 2002 AbstractBackgroundDiabetes mellitus is a well‐known cause of gastrointestinal dysmotility. The pathogenesis of diabetic gastroenteropathy is mainly considered to be a ... Full text Cite