Journal ArticleJournal of hematology & oncology · August 2024
Multiple classes of therapies targeting claudin-18 isoform 2 (CLDN18.2) are under development for the treatment of advanced gastroesophageal adenocarcinoma and other solid tumors. At the 2024 American Society of Clinical Oncology (ASCO) Annual Meeting, the ...
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Journal ArticleJ Hematol Oncol · March 3, 2023
Developments in investigational agents and novel regimens in acute myeloid leukemia (AML) were reported in the 2022 American Society of Hematology (ASH) annual meeting. Encouraging efficacy data were presented from first-in-human studies of two investigati ...
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Journal ArticleEur J Haematol · December 2019
BACKGROUND: To make a definite diagnosis of essential thrombocytosis (ET) from reactive thrombocytosis (RT), the most reliable criteria are the presence of driver mutations, namely JAK2, CALR, or MPL gene mutations. In the absence of these driver mutations ...
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Journal ArticlePLoS One · 2016
Endogenous erythroid colony (EEC) formation is one of the minor criteria for diagnosing polycythemia vera (PV) according to 2008 WHO diagnostic criteria. But EEC requires bone marrow aspiration and sophisticated laboratory procedures; therefore, practicall ...
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Journal ArticleNeurogastroenterology & Motility · July 2008
Abstract Intestinal obstructions lead to a variety of motility disorders. Small intestine smooth muscles undergo dramatic phenotypic changes in response to obstruction, but the underlying molecular mechanisms are unknown. Us ...
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Journal ArticlePhysiological Genomics · November 2007
Interstitial cells of Cajal (ICC) have important functions in regulation of motor activity in the gastrointestinal tract. In murine small intestine, ICC are gathered in the regions of the myenteric plexus (ICC-MY) and the deep muscular plexus (ICC- ...
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Journal ArticleProceedings of the National Academy of Sciences · October 9, 2007
Peripheral inhibitory nerves are physiological regulators of the contractile behavior of visceral smooth muscles. One of the transmitters responsible for inhibitory neurotransmission has been reputed to be a purine, possibly ATP. However, the exact ...
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Journal ArticleAmerican Journal of Physiology-Cell Physiology · January 2007
Specific functions of interstitial cells of Cajal (ICC) have been linked to distinct classes that differ by morphology and distribution. In the small intestine, slow wave-generating ICC are located in the myenteric region (ICC-MY), whereas ICC tha ...
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Journal ArticleNeurogastroenterology & Motility · June 2006
Depletion of ICC networks and consequent changes in electrical slow wave activity and neuromuscular neurotransmission play important roles in diabetic and idiopathic gastroparesis. We have shown that reduced insulin/IGF‐I signaling and consequent d ...
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Journal ArticleInternational Journal of Cancer · May 20, 2003
AbstractMutations of proto‐oncogene c‐KIT in gastrointestinal stromal tumors (GISTs) are considered to cause a constitutive activation of KIT responsible for their oncogenesis. Imatinib has therapeutic potential for GISTs b ...
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Journal ArticleJournal of Gastroenterology and Hepatology · February 2003
AbstractBackground and Aim: Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the human gut. They frequently have gain‐of‐function mutations of the c‐kit gene, which en ...
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Journal ArticleJournal of Gastroenterology and Hepatology · June 2002
AbstractBackgroundDiabetes mellitus is a well‐known cause of gastrointestinal dysmotility. The pathogenesis of diabetic gastroenteropathy is mainly considered to be a ...
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