Ines Batinic-Haberle

Professor Emeritus of Radiation Oncology

Radiation Oncology

ibatinic@duke.edu

Box 3839 Med Ctr, Durham, NC 27710

Duke Hospital South, Orange Zone, Room 5317, 200 Trent Drive, Durham, NC 27710

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Scholarly Works - Conferences

Neuro-pharmacokinetic assessment of manganese porphyrin-based superoxide dismutase mimics

Conference Free Radical Biology and Medicine · November 2025 Full text Cite

Results of a Randomized Phase 2 Study of a Novel Superoxide Dismutase Mimetic in Patients with Multiple Brain Metastases undergoing Whole-Brain Radiotherapy

Conference INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS · September 1, 2025 Link to item Cite

Formation and Decomposition of the Mn(II)P-NO Complex In Vitro: Potential Role in Mitochondrial Peroxynitrite Formation

Conference Free Radical Biology and Medicine · November 2023 Full text Cite

RESULTS OF BMX-HGG STUDY: A MULTI-INSTITUTIONAL, RANDOMIZED PHASE 2 CLINICAL TRIAL OF CONCURRENT CHEMORADIATION WITH OR WITHOUT BMX-001 IN PATIENTS WITH NEWLY DIAGNOSED HIGH GRADE GLIOMA

Conference NEURO-ONCOLOGY · November 2023 Link to item Cite

Ascorbate exhibits anti-tumorigenic effects in pre-clinical models of endometrioid endometrial cancer (043)

Conference Gynecologic Oncology · September 2023 Full text Cite

Antioxidant and Pro-Oxidant Actions of Mn Porphyrin-Based Therapeutics

Conference Free Radical Biology and Medicine · February 2022 Full text Cite

2021 SFRBM DISCOVERY AWARD LECTURE

Conference Free Radical Biology and Medicine · February 2022 Full text Cite

MnTnBuOE-2-PyP5+ Ascorbate in the Treatment of Ovarian Cancer

Conference Free Radical Biology and Medicine · November 2020 Full text Cite

BMX-HGG: Phase II trial of newly diagnosed high-grade glioma treated with concurrent radiation therapy, temozolomide, and BMX-001.

Conference JOURNAL OF CLINICAL ONCOLOGY · May 20, 2020 Link to item Cite

Cognitive Outcomes of Phase I Trial of Novel Metalloporphyrin Radioprotectant and Radiosensitizer in Newly Diagnosed High Grade Glioma Patients.

Conference Supportive Care in Cancer · 2020 MASCC20-ABS-1534 ... Cite

PHASE 1 DOSE ESCALATION TRIAL OF THE SAFETY OF BMX-001 CONCURRENT WITH RADIATION THERAPY AND TEMOZOLOMIDE IN NEWLY DIAGNOSED PATIENTS WITH HIGH-GRADE GLIOMAS

Conference NEURO-ONCOLOGY · November 5, 2018 ACTR-28 ... Full text Link to item Cite

Mn porphyrin/ascorbate sensitizes serous epithelial ovarian cancer to chemotherapy

Conference Free Radical Biology and Medicine · November 2018 Full text Cite

Application of resonance raman spectroscopy on manganese porphyrin detection and redox state in endothelial cells: implications on cytoprotection towards peroxynitrite

Conference Free Radical Biology and Medicine · November 2018 Full text Cite

Manganese superoxide dismutase regulates mTORC2 mediated UVB-induced mitophagy

Conference Free Radical Biology and Medicine · November 2018 Full text Cite

Mn- and Fe-porphyrin-based SOD mimics are powerful suppressors of itch in histamine-dependent and -independent mouse models

Conference Free Radical Biology and Medicine · November 2018 Full text Cite

Beneficial impact of a manganese(III) porphyrin in cancer cell migration

Conference Free Radical Biology and Medicine · May 2018 Full text Cite

Resonance raman studies on manganese porphyrin detection and redox state in endothelial cells: implications for antioxidant cytoprotection

Conference Free Radical Biology and Medicine · May 2018 Full text Cite

ROS regulate developmental and pathological denervation in vivo

Conference Free Radical Biology and Medicine · May 2018 Full text Cite

Protection Of Neurocognitive Function During Cranial Irradiation Of Brain Tumors

Conference Free Radical Biology and Medicine · November 2017 Full text Cite

A Novel MnSOD Mimetic Targets Various Redox States to Selectively Treat Hematopoietic Malignancies via Control of AP-1 Signaling

Conference Free Radical Biology and Medicine · November 2017 Full text Cite

Novel fluorinated Mn porphyrin as a powerful SOD mimic and catalyst for ascorbate-coupled anticancer therapy

Conference Free Radical Biology and Medicine · November 2017 Full text Cite

Protection of rat prostate and erectile function from radiation-induced damage by novel Mn(III) N- substituted pyridylporphyrin and ascorbate

Conference Free Radical Biology and Medicine · November 2017 Full text Cite

Viability and migration of human renal cancer cells upon treatment with a superoxide dismutase mimic

Conference Toxicology Letters · October 2017 Full text Cite

Application of Resonance Raman spectroscopy for the direct detection of manganese porphyrins and their redox state in endothelial cells

Conference Free Radical Biology and Medicine · July 2017 Full text Cite

Chemometric optimization of the synthesis of meso-tetrakis(2-pyridyl) porphyrin: precursor of redox-active therapeutics

Conference JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY · July 1, 2017 Link to item Cite

A(3)B-type Mn(III) 2-N-methylpyridylporphyrins for development of superoxide dismutase mimics and redox-active therapeutics

Conference JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY · July 1, 2017 Link to item Cite

Redox Proteomics of 4T1 Breast Cancer Cell After Treatment with MnTE-2-PyP5+/Ascorbate System

Conference Free Radical Biology and Medicine · November 2016 Full text Cite

Catalysis of Sulfite Oxidation Adds to the Array of Biologically Relevant Reactions of Cationic Mn(III) Porphyrins, Widely Known as SOD-Mimics

Conference Free Radical Biology and Medicine · November 2016 Full text Cite

Resonance Raman Studies on Manganese Porphyrin Detection and Redox State in Endothelial Cells

Conference Free Radical Biology and Medicine · November 2016 Full text Cite

A Novel Redox Based Therapy Targets the Malignant Cellular Redox State

Conference Free Radical Biology and Medicine · November 2016 Full text Cite

Manganese Porphyrin, MnTE-2-PyP5+, Enhances Chemotherapeutic Response in Hematological Malignancies

Conference Free Radical Biology and Medicine · November 2016 Full text Cite

Redox-Active Mn Porphyrins, MnTE-2-PyP5+ and MnTnBuOE-2-PyP5+ But Not Redox-Inert MnTBAP3-Suppress Tumor Growth in an Environment Where H2O2 Is Produced

Conference Free Radical Biology and Medicine · November 2016 Full text Cite

RADIOPROTECTION OF ERECTILE FUNCTION USING NOVEL ANTI-OXIDANT IN THE RAT

Conference JOURNAL OF SEXUAL MEDICINE · May 1, 2015 Link to item Cite

A METALLOPORPHYRIN CATALYTIC OXIDOREDUCTANT IS PROTECTIVE AFTER SPINAL CORD INJURY IN A RAT MODEL

Conference JOURNAL OF NEUROTRAUMA · August 1, 2013 Link to item Cite

Abstract 5552: Manganese porphyrins in combination with ascorbate act as pro-oxidants and mediate caspase-independent cancer cell death.

Conference Cancer Research · April 15, 2013 AbstractResistance to therapy-mediated apoptosis in inflammatory breast cancer (IBC), an aggressive and distinct subtype of breast cancer was recently attributed to increased antioxidant expression (superoxi ... Full text Cite

RADIOPROTECTION OF BRAIN WHITE MATTER BY THE CATALYTIC MnSOD MIMIC/ANTIOXIDANT, BMX-001

Conference NEURO-ONCOLOGY · April 1, 2013 Link to item Cite

Comprehensive Pharmacokinetic Studies and Biodistribution of Two Cationic Mn Porphyrin-Based Catalysts, MnTE-2-PyP5+ and MnTnHex-2-PyP5+: Plasma and Organ Oral Availability, Mitochondrial, Cytosolic, Whole Brain, Hippocampus and Cortex Distribution

Conference Free Radical Biology and Medicine · November 2012 Full text Cite

Understanding Differences in Mechanisms of Action of Fe vs Mn Porphyrins: Comparison of Their Reactivities Towards Cellular Reductants and Reactive Species

Conference Free Radical Biology and Medicine · November 2012 Full text Cite

Structure-activity and bioavailability studies drive development of cationic Mn porphyrins as cancer and central nervous system therapeutics

Conference ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY · August 19, 2012 Link to item Cite

Effects of alkyl chain length of Zn N-alkylpyridylporphyrins on photo-mediated protein crosslinking

Conference FASEB JOURNAL · April 1, 2012 Link to item Cite

Lipophilicity of Mn(III) N-Alkylpyridylporphyrins Dominates Their Accumulation Within Mitochondria and Therefore in Vivo Efficacy: a Mouse Study

Conference Free Radical Biology and Medicine · November 2011 Full text Cite

Lipophilic Mn Porphyrins in the Treatment of Brain Tumors

Conference Free Radical Biology and Medicine · November 2011 Full text Cite

Timely Administration of Mn porphyrin, MnTM-2PyP5+ is Critical to Afford Protection in Diabetes: a Rat Study

Conference Free Radical Biology and Medicine · November 2011 Full text Cite

Experimental and Computational Studies on Mn Porphyrin-Based Therapeutics: Unforeseen Intramolecular Rearrangements on Methoxyalkyl Analogues of MnTE-2-PyP5+ and MnTnHex-2-PyP5+

Conference Free Radical Biology and Medicine · November 2011 Full text Cite

Fe porphyrins Revisited: Synthesis, Characterization and the Effects of Ortho and Meta Fe(III) N-Alkylpyridylporphyrins Upon the Growth of E. Coli in the Presence and Absence of Ascorbate

Conference Free Radical Biology and Medicine · November 2011 Full text Cite

A Breakthrough in the Development of SOD Mimics/Cellular Redox Modulators: a Superior Mn porphyrin, MnTnBuOE-2-PyP5+ With Finely Tuned Properties

Conference Free Radical Biology and Medicine · November 2011 Full text Cite

4-Hydroxy-2-Nonenal Mediates Aifm2 Release From Mitochondria: An Insight Into the Mechanism of Oxidative Stress Mediated Retrograde Signaling

Conference Free Radical Biology and Medicine · November 2011 Full text Cite

Understanding Protonation and Redox Equilibria of Metal site of Mn Porphyrin-based Cellular Redox Modulators is Essential for Comprehending their ROS-related Chemistry and Biology

Conference Free Radical Biology and Medicine · 2010 Full text Cite

Thermal Stability of MnTE-2-PyPCl5, a Potent Catalytic Antioxidant and Cellular Redox Modulator

Conference Free Radical Biology and Medicine · 2010 Full text Cite

Cationic Mn Porphyrins Change Their Action from anti- to pro-oxidative in the Presence of Cellular Reductants: Relevance to understanding the beneficial therapeutic effects of SOD mimics in vivo

Conference Free Radical Biology and Medicine · 2010 Full text Cite

Structural Modification Diminishes Toxicity of Lipophilic Longer Mn(III) N-alkylpyridyl porphyrin-based Powerful SOD Mimics: Synthesis, Characterization and SOD-deficient E. coli and S. cerevisiae studies

Conference Free Radical Biology and Medicine · 2010 Full text Cite

Accumulation of Porphyrin-based SOD Mimics in Mitochondria is Proportional to Their Lipophilicity: S. cerevisiae Study of ortho Mn(III) N-alkylpyridylporphyrins

Conference Free Radical Biology and Medicine · 2010 Full text Cite

Effect of Mn Porphyrins and Antioxidants on MRI Predictors and Behavior in an Animal Model of Cerebral Palsy

Conference Free Radical Biology and Medicine · 2010 Full text Cite

Mn porphyrins suppress oxidative stress injuries through redox-based pathways

Conference AMINO ACIDS · July 1, 2009 Link to item Cite

Zn(II) N-alkylpyridyl-porphyrin photosensitizers target structural proteins and enzymes: Impact of lipophilicity

Conference AMINO ACIDS · July 1, 2009 Link to item Cite

Increased Lipophilicity of meta Mn(III) N-alkylpyridylporphyrins, when Compared to ortho isomers, Fully Compensates for their Lower SOD-like Activity when Protecting SOD-deficient E. coli

Conference FREE RADICAL BIOLOGY AND MEDICINE · January 1, 2009 Link to item Cite

Lipophilicity of Potent Mn Porphyrin-based SOD and Peroxynitrite Reductase Mimics is Redox Modulated

Conference FREE RADICAL BIOLOGY AND MEDICINE · January 1, 2009 Link to item Cite

The in vitro Cytotoxic Effects of Mn(III) Alkylpyridylporphyrin/ascorbate system on Four Tumor Cell Lines

Conference FREE RADICAL BIOLOGY AND MEDICINE · January 1, 2009 Link to item Cite

Mntbap Selectively Scavenges Peroxynitrite Over Superoxide: Comparison of Mntbap to Mnte-2-Pyp in Two Different Models of Oxidative Stress Injuries, SOD-Specific E-coli Model and Carrageenan-Induced Pleurisy

Conference FREE RADICAL BIOLOGY AND MEDICINE · January 1, 2008 Link to item Cite

Lipophilicity Is a Critical Parameter That Dominates the Efficacy of Metalloporphyrins in Blocking the Development of Morphine Antinociceptive Tolerance Through Peroxynitrite Mediated Pathways

Conference FREE RADICAL BIOLOGY AND MEDICINE · January 1, 2008 Link to item Cite

Oral Availability of Mnte-2-Pyp(5+), a Potent Antioxidant and Cellular Redox Modulator

Conference FREE RADICAL BIOLOGY AND MEDICINE · January 1, 2008 Link to item Cite

Overproduction of beta-amyloid peptides induces chronic oxidative stress and suppresses MnSOD expression in mature neurons: implications for Alzheimer's disease

Conference FREE RADICAL BIOLOGY AND MEDICINE · January 1, 2007 Link to item Cite

Pure MnTBAP is not a superoxide dismutase mimic in aqueous systems: A case of structure-activity relationship as a watchdog mechanism in experimental therapeutics and biology

Conference FREE RADICAL BIOLOGY AND MEDICINE · January 1, 2007 Link to item Cite

Design and biodistribution of MN porphyrin-based therapeutics for oxidative stress

Conference FREE RADICAL BIOLOGY AND MEDICINE · January 1, 2007 Link to item Cite

Recent advances in understanding structure-activity relationships of Mn porphyrin-based therapeutics: Charge distribution and electrostatic effects

Conference FREE RADICAL BIOLOGY AND MEDICINE · January 1, 2007 Link to item Cite

Mn porphyrin-based SOD mimic, MnTe-2-PyP5+ (AEOL-10113), targets mouse heart mitochondria after single 10 Mg/Kg IP administration

Conference FREE RADICAL BIOLOGY AND MEDICINE · January 1, 2006 Link to item Cite

Metalloporphyrins mimic cyt P450 in activating cyclophosphamide in biologically relevant system

Conference FREE RADICAL BIOLOGY AND MEDICINE · January 1, 2006 Link to item Cite

Metalloporphyrin mediated protection from renal ischemia/reperfusion injury

Conference FREE RADICAL BIOLOGY AND MEDICINE · January 1, 2006 Link to item Cite