Journal articleThe journals of gerontology. Series A, Biological sciences and medical sciences · October 2018
The special design of the Long Life Family Study provides a unique opportunity to investigate the genetics of human longevity by analyzing data on exceptional lifespans in families. In this article, we performed two series of genome wide association studie ...
Full textCite
Journal articleExp Gerontol · September 2018
Longer lifespan is accompanied by a larger number of chronic diseases among older adults. Because of a growing proportion of older adults in the U.S., this brings the problem of age-related morbidity to the forefront as a major contributor to rising medica ...
Full textLink to itemCite
Journal articleExperimental gerontology · July 2018
Despite evident success in clarifying many important features of Alzheimer's disease (AD) the efficient methods of its prevention and treatment are not yet available. The reasons are likely to be the fact that AD is a multifactorial and heterogeneous healt ...
Full textCite
Journal articlePhysical Review D · July 1, 2018
Radiative corrections to the cross sections of photon electroproduction and the single spin asymmetries induced by the interference between the Bethe-Heitler and deep virtual Compton scattering amplitudes are calculated within the leading log approximation ...
Full textCite
Journal articleJ Diabetes Complications · April 2018
AIMS: To identify how efforts to control the diabetes epidemic and the resulting changes in diabetes mellitus, type II (T2D) incidence and survival have affected the time-trend of T2D prevalence. METHODS: A newly developed method of trend decomposition was ...
Full textLink to itemCite
Journal articleJ Alzheimers Dis · 2018
BACKGROUND: Trends in the prevalence of cognitive impairment (CI) based on cognitive assessment instruments are often inconsistent with those of neurocognitive disorders (ND) based on Medicare claims records. OBJECTIVE: We hypothesized that improved ascert ...
Full textLink to itemCite
Journal articleN C Med J · 2018
BACKGROUND Life expectancy in southeastern North Carolina communities located in an area with multiple concentrated animal feeding operations (CAFOs) after adjusting for socioeconomic factors remains low. We hypothesized that poor health outcomes in this r ...
Full textLink to itemCite
Journal articleAnesth Analg · October 2017
BACKGROUND: Declining platelet counts may reveal platelet activation and aggregation in a postoperative prothrombotic state. Therefore, we hypothesized that nadir platelet counts after on-pump coronary artery bypass grafting (CABG) surgery are associated w ...
Full textOpen AccessLink to itemCite
Journal articleTheor Popul Biol · April 2017
In this study, we present a new theory of partitioning of disease prevalence and incidence-based mortality and demonstrate how this theory practically works for analyses of Medicare data. In the theory, the prevalence of a disease and incidence-based morta ...
Full textOpen AccessLink to itemCite
Journal articleBMC bioinformatics · February 2017
BackgroundThe Stochastic Process Model (SPM) represents a general framework for modeling the joint evolution of repeatedly measured variables and time-to-event outcomes observed in longitudinal studies, i.e., SPM relates the stochastic dynamics of ...
Full textOpen AccessCite
Journal articleJ Cardiothorac Vasc Anesth · October 2016
OBJECTIVE: The authors hypothesized that average precardiopulmonary bypass (pre-CPB) transesophageal echocardiographic (TEE) mean gradient (PGm) and aortic valve area (AVA) values would be significantly different from preoperative transthoracic (TTE) value ...
Full textOpen AccessLink to itemCite
Journal articleAnesth Analg · April 2016
BACKGROUND: Current guidelines define severe aortic valve stenosis (AS) as an aortic valve area (AVA) ≤1.0 cm by the continuity equation and mean gradient (ΔPm) ≥ 40 mm Hg. However, these measurements can be discordant when classifying AS severity. Approxi ...
Full textOpen AccessLink to itemCite
Journal articleJ Gen Intern Med · March 2016
BACKGROUND: Patient complexity is often operationalized by counting multiple chronic conditions (MCC) without considering contextual factors that can affect patient risk for adverse outcomes. OBJECTIVE: Our objective was to develop a conceptual model of co ...
Full textOpen AccessLink to itemCite
Journal articleBiogerontology · February 2016
Complex diseases are major contributors to human mortality in old age. Paradoxically, many genetic variants that have been associated with increased risks of such diseases are found in genomes of long-lived people, and do not seem to compromise longevity. ...
Full textOpen AccessCite
Journal articleBiogerontology · February 2016
Increasing proportions of elderly individuals in developed countries combined with substantial increases in related medical expenditures make the improvement of the health of the elderly a high priority today. If the process of aging by individuals is a ma ...
Full textOpen AccessCite
Journal articleNorth American actuarial journal : NAAJ · January 2016
Background and objectiveTo clarify mechanisms of genetic regulation of human aging and longevity traits, a number of genome-wide association studies (GWAS) of these traits have been performed. However, the results of these analyses did not meet ex ...
Full textOpen AccessCite
Journal articleFrontiers in genetics · January 2016
This paper shows that the effects of causal SNPs on lifespan, estimated through GWAS, may be confounded and the genetic structure of the study population may be responsible for this effect. Simulation experiments show that levels of linkage disequilibrium ...
Full textOpen AccessCite
Journal articleJ Natl Cancer Inst · December 2015
BACKGROUND: Impact of contemporary treatment of pre-invasive breast cancer (ductal carcinoma in situ [DCIS]) on long-term outcomes remains poorly defined. We aimed to evaluate national treatment trends for DCIS and to determine their impact on disease-spec ...
Full textLink to itemCite
Journal articleLung Cancer · April 2015
OBJECTIVES: To evaluate the role of cardiovascular disease (CVD) comorbidity in survival of patients with non-small cell lung cancer (NSCLC). MATERIALS AND METHODS: The impact of seven CVDs (at the time of NSCLC diagnosis and during subsequent follow-up) o ...
Full textOpen AccessLink to itemCite
Journal articleAnn Surg Oncol · February 2015
BACKGROUND: We evaluated the use and efficacy of adjuvant chemotherapy after resection of T1-2N1M0 non-small cell lung cancer (NSCLC) in elderly patients. METHODS: Factors associated with the use of adjuvant chemotherapy in patients older than 65 years of ...
Full textOpen AccessLink to itemCite
Journal articleCan J Anaesth · January 2015
PURPOSE: Timely communication of intraoperative transesophageal echocardiography (TEE) findings to the postoperative care team is critical to optimizing patient care. We compared the use of a personal computer (PC) system with the use of a mobile tablet de ...
Full textOpen AccessLink to itemCite
Journal articleEuropean Physical Journal A · January 1, 2015
The clear 7σ discrepancy between measurements of the proton charge radius from muonic hydrogen Lamb shifts and those from hydrogen Lamb shift and electron scattering lead to both intense theoretical and experimental efforts to understand and explain this d ...
Full textOpen AccessCite
Journal articleFrontiers in genetics · January 2015
BackgroundThe roles of genetic factors in human longevity would be better understood if one can use more efficient methods in genetic analyses and investigate pleiotropic effects of genetic variants on aging and health related traits.Data and ...
Full textOpen AccessCite
Journal articlePLoS One · 2015
BACKGROUND: Treatment selection for elderly patients with lung cancer must balance the benefits of curative/life-prolonging therapy and the risks of increased mortality due to comorbidities. Lung cancer trials generally exclude patients with comorbidities ...
Full textOpen AccessLink to itemCite
Journal articleSci Total Environ · August 1, 2014
Elevated level of fluoride (F(-)) in drinking water is a well-recognized risk factor of dental fluorosis (DF). While considering optimization of region-specific standards for F(-), it is reasonable, however, to consider how local diet, water sourcing pract ...
Full textOpen AccessLink to itemCite
Journal articlePhysical Review D Particles Fields Gravitation and Cosmology · August 1, 2014
Radiative effects in the electroproduction of photons in polarized ep scattering are calculated with next-to-leading-order accuracy. The contributions of loops and two-photon emission are presented in analytical form. The covariant approach of Bardin and S ...
Full textOpen AccessCite
Journal articleAnnals of epidemiology · June 2014
PurposeGliomas are one of the most fatal malignancies, with largely unknown etiology. This study examines a possible connection between glioma and melanoma, which might provide insight into gliomas' etiology.MethodsUsing data provided by ...
Full textOpen AccessCite
Journal articleJ Thorac Cardiovasc Surg · April 2014
OBJECTIVE: Recently, the role of β-blockers (BBs) in reducing perioperative mortality has been challenged. The conflicting results might have resulted from the extent of BB metabolism by the cytochrome P-450 (CYP2D6) isoenzyme. The purpose of the present s ...
Full textOpen AccessLink to itemCite
Journal articleInt J Chron Obstruct Pulmon Dis · 2014
BACKGROUND: The respiratory tract is a major target of exposure to air pollutants, and respiratory diseases are associated with both short- and long-term exposures. We hypothesized that improved air quality in North Carolina was associated with reduced rat ...
Full textOpen AccessLink to itemCite
Journal articleFrontiers in public health · January 2014
Longitudinal data on aging, health, and longevity provide a wealth of information to investigate different aspects of the processes of aging and development of diseases leading to death. Statistical methods aimed at analyses of time-to-event data jointly w ...
Full textOpen AccessCite
Journal articleESAIM. Probability and statistics = Probabilites et statistique : P & S · January 2014
We consider representations of a joint distribution law of a family of categorical random variables (i.e., a multivariate categorical variable) as a mixture of independent distribution laws (i.e. distribution laws according to which random va ...
Full textOpen AccessCite
Journal articleDis Esophagus · 2014
We examined outcomes and trends in surgery and radiation use for patients with locally advanced esophageal cancer, for whom optimal treatment isn't clear. Trends in surgery and radiation for patients with T1-T3N1M0 squamous cell or adenocarcinoma of the mi ...
Full textOpen AccessLink to itemCite
Journal articleExp Gerontol · December 2013
Multi-morbidity is common among older adults; however, for many aging-related diseases there is no information for U.S. elderly population on how earlier-manifested disease affects the risk of another disease manifested later during patient's lifetime. Qua ...
Full textOpen AccessLink to itemCite
Journal article2013 ACM Conference on Bioinformatics Computational Biology and Biomedical Informatics ACM Bcb 2013 · November 28, 2013
The model to evaluate and predict the effectiveness of treatment of the Major Depressive Disorder (MDD) was developed and estimated using MindLinc data. The clinical global impression (CGI) scale with seven categories was used to measure the patient's stat ...
Full textOpen AccessCite
Journal articleExp Gerontol · August 2013
OBJECTIVES: Considering disease incidence to be a main contributor to healthy lifespan of the US elderly population may lead to erroneous conclusions when recovery/long-term remission factors are underestimated. Using two Medicare-based population datasets ...
Full textOpen AccessLink to itemCite
Journal articleAge Ageing · July 2013
OBJECTIVES: time trends of age-adjusted incidence rates of 19 ageing-related diseases were evaluated for 1992-2005 period with the National Long Term Care Survey and the Surveillance, Epidemiology and End RESULTS Registry data both linked to Medicare data ...
Full textOpen AccessLink to itemCite
Journal articleRes Aging · July 2013
Incidence rates of acute coronary heart disease (ACHD; including myocardial infarction and angina pectoris), stroke, and heart failure (HF) were studied for their age, disability, and comorbidity patterns in the U.S. elderly population using the National L ...
Full textOpen AccessLink to itemCite
Journal articleJ Thorac Oncol · June 2013
INTRODUCTION: : We evaluated treatment patterns of elderly patients with stage IIIA (N2) non-small-cell lung cancer (NSCLC). METHODS: : The use of surgery, chemotherapy, and radiation for patients with stage IIIA (T1-T3N2M0) NSCLC in the Surveillance, Epid ...
Full textOpen AccessLink to itemCite
Journal articleVoprosy onkologii · January 2013
The myelodepression at therapy for solid malignancies is considered as a mediating element of common antineoplastic activity on the basis of ability of stem cells of hemapoietic system to participate in regeneration of the various tissues of the body, incl ...
Cite
Journal articleFrontiers in genetics · January 2013
Background and objectiveThe influence of genes on human lifespan is mediated by biological processes that characterize body's functioning. The age trajectories of these processes contain important information about mechanisms linking aging, health ...
Full textOpen AccessCite
Journal articleNorth American Actuarial Journal · December 1, 2012
The objective of this paper is to investigate dynamic properties of age trajectories of physiological indices and their effects on mortality risk and longevity using longitudinal data on more than 5,000 individuals collected in biennial examinations of the ...
Full textOpen AccessCite
Journal articleJ Am Coll Surg · November 2012
BACKGROUND: We examined survival associated with locally advanced esophageal squamous cell cancer (SCC) to evaluate if treatment without surgery could be considered adequate. STUDY DESIGN: Patients in the Surveillance, Epidemiology and End Results Registry ...
Full textOpen AccessLink to itemCite
Journal articleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · November 2012
IntroductionThe optimal timing of primary and metastatic tumor management in patients with synchronous hepatic colorectal metastases remains controversial. We aimed to compare perioperative outcomes of simultaneous colorectal/liver resection (SCLR ...
Full textOpen AccessCite
Journal articleComputer Physics Communications · July 1, 2012
The structure and algorithms of the Monte Carlo generator ELRADGEN 2.0 designed to simulate radiative events in polarized ep-scattering are presented. The full set of analytical expressions for the QED radiative corrections is presented and discussed in de ...
Full textOpen AccessCite
Journal articlePhysics of life reviews · June 2012
A better understanding of processes and mechanisms linking human aging with changes in health status and survival requires methods capable of analyzing new data that take into account knowledge about these processes accumulated in the field. In this paper, ...
Full textOpen AccessCite
Journal articleAnn Surg Oncol · April 2012
BACKGROUND: Management and outcomes of patients with invasive intraductal papillary mucinous neoplasm (IPMN) of the pancreas are not well established. We investigated whether adjuvant radiotherapy (RT) improved cancer-specific survival (CSS) and overall su ...
Full textOpen AccessLink to itemCite
Journal articlePhysical Review D Particles Fields Gravitation and Cosmology · March 28, 2012
Radiative effects in the electroproduction of photons in polarized ep scattering are calculated in the leading log approximation and analyzed numerically for kinematical conditions of current measurement at Jefferson Lab. Radiative corrections to the cross ...
Full textOpen AccessCite
Journal articleMath Biosci · March 2012
In this paper we present a new multiple-pathway stochastic model of carcinogenesis with potential of predicting individual incidence risks on the basis of biomedical measurements. The model incorporates the concept of intracellular barrier mechanisms in wh ...
Full textOpen AccessLink to itemCite
Journal articleJ Am Geriatr Soc · February 2012
OBJECTIVES: To use the Medicare Files of Service Use (MFSU) to evaluate patterns in the incidence of aging-related diseases in the U.S. elderly population. DESIGN: Age-specific incidence rates of 19 aging-related diseases were evaluated using the National ...
Full textOpen AccessLink to itemCite
Journal articlePLoS One · 2012
BACKGROUND: HIV-1-positive patients clear the human papillomavirus (HPV) infection less frequently than HIV-1-negative. Datasets for estimating HPV clearance probability often have irregular measurements of HPV status and risk factors. A new transitional p ...
Full textOpen AccessLink to itemCite
Journal articlePLoS One · 2012
BACKGROUND: Adenocarcinomas (ACs) and squamous cell carcinomas (SCCs) differ by clinical and molecular characteristics. We evaluated the characteristics of carcinogenesis by modeling the age patterns of incidence rates of ACs and SCCs of various organs to ...
Full textOpen AccessLink to itemCite
Journal articleMathematical Population Studies · December 1, 2011
Data on individual health histories, age trajectories of physiological or biological variables, and mortality allow for the study of the joint evolution of health and physiological states and their effects on mortality. Individual health and physiological ...
Full textOpen AccessCite
Journal articleBreast Cancer Res Treat · November 2011
Inflammatory Breast Carcinoma (IBC), the most aggressive type of breast tumor with unique clinicopathological presentation, is hypothesized to have distinct etiology with a socioeconomic status (SES) component. Using the Surveillance, Epidemiology and End ...
Full textLink to itemCite
Journal articleBreast Cancer Res Treat · July 2011
The observed bimodal patterns of breast cancer incidence in the U.S. suggested that breast cancer may be viewed as more than one biological entity. We studied the factors potentially contributing to this phenomenon, specifically focusing on how disease het ...
Full textOpen AccessLink to itemCite
Journal articleAging cell · June 2011
Progress in unraveling the genetic origins of healthy aging is tempered, in part, by a lack of replication of effects, which is often considered a signature of false-positive findings. We convincingly demonstrate that the lack of genetic effects on an agin ...
Full textOpen AccessCite
Journal articleRadiation and environmental biophysics · May 2011
A new model of the hematopoietic system response in humans chronically exposed to ionizing radiation describes the dynamics of the hematopoietic stem cell compartment as well as the dynamics of each of the four blood cell types (lymphocytes, neutrophiles, ...
Full textOpen AccessCite
Journal articleBiogerontology · April 2011
Small sample size of genetic data is often a limiting factor for desirable accuracy of estimated genetic effects on age-specific risks and survival. Longitudinal non-genetic data containing information on survival or disease onsets of study participants fo ...
Full textOpen AccessCite
Journal articleMechanisms of ageing and development · March 2011
We analysed relationship between the risk of onset of "unhealthy life" (defined as the onset of cancer, cardiovascular diseases, or diabetes) and longitudinal changes in body mass index, diastolic blood pressure, hematocrit, pulse pressure, pulse rate, and ...
Full textOpen AccessCite
Journal articleComput Math Methods Med · 2011
Time trajectories of medical costs-associated with onset of twelve aging-related cancer and chronic noncancer diseases were analyzed using the National Long-Term Care Survey data linked to Medicare Service Use files. A special procedure for selecting indiv ...
Full textOpen AccessLink to itemCite
Journal articleHealth physics · September 2010
The major goal of this study is to investigate and quantitatively describe the nature of the relationship between the characteristics of chronic exposure to ionizing radiation and specific patterns of hematopoiesis reduction. The study is based on about 3, ...
Full textOpen AccessCite
Journal articleHealth physics · September 2010
A new model of the hematopoietic system for humans chronically exposed to ionizing radiation allows for quantitative description of the initial hematopoiesis inhibition and subsequent increase in the risks of late stochastic effects such as leukemia. This ...
Full textOpen AccessCite
Journal articleRejuvenation research · August 2010
Relationships between aging, disease risks, and longevity are not yet well understood. For example, joint increases in cancer risk and total survival observed in many human populations and some experimental aging studies may be linked to a trade-off betwee ...
Full textOpen AccessCite
Journal articleBiogerontology · June 2010
Exceptional survival results from complicated interplay between genetic and environmental factors. The effects of these factors on survival are mediated by the biological and physiological variables, which affect mortality risk. In this paper, we evaluated ...
Full textCite
Journal articleRadiation and environmental biophysics · May 2010
The major goal of this study was to identify and quantitatively describe the association between the characteristics of chronic (low-dose rate) exposure to (low LET) ionizing radiation and cellularity of peripheral blood cell lines. About 3,200 hemograms ( ...
Full textOpen AccessCite
Journal articleStroke · March 2010
Background and purposeImprovements in recovery rates may contribute to an increase in healthy life expectancy. It is unclear, however, whether such changes take place because health researchers traditionally deal with changes in incidence and surv ...
Full textCite
Journal articleRejuvenation research · February 2010
Multiple functions of the beta2-adrenergic receptor (ADRB2) and angiotensin-converting enzyme (ACE) genes warrant studies of their associations with aging-related phenotypes. We focus on multimarker analyses and analyses of the effects of compound genotype ...
Full textOpen AccessCite
Journal articleVoprosy onkologii · January 2010
To investigate the deviation of survival curves from monotonous shape, 17 curves for 6 most common cancer sites of 87,205 patients (aged 30-89) were selected from The U.S. Surveillance, Epidemiology and End Results (SEER) Register database. The curves were ...
Cite
Journal articleCurr Gerontol Geriatr Res · 2010
It is well known from epidemiology that values of indices describing physiological state in a given age may influence human morbidity and mortality risks. Studies of connection between aging and life span suggest a possibility that dynamic properties of ag ...
Full textLink to itemCite
Journal articleInternational Journal of Low Radiation · January 1, 2010
This paper describes a new approach to modelling carcinogenesis, including that induced by ionising radiation. The specific feature of the developed approach is that the model, still adhering to the mutational theory of carcinogenesis, includes parameters ...
Full textCite
Journal articleMechanisms of ageing and development · September 2009
The levels of blood glucose (BG) in humans tend to increase with age deviating from the norm specified for the young adults. Such elevation is often considered as a factor contributing to an increase in risks of disease and death. The proper use of interve ...
Full textCite
Journal articleJournal of theoretical biology · May 2009
Many longitudinal studies of aging collect genetic information only for a sub-sample of participants of the study. These data also do not include recent findings, new ideas and methodological concepts developed by distinct groups of researchers. The formal ...
Full textCite
Journal articleMathematical biosciences · April 2009
The results of recent experimental and epidemiological studies provide evidence on the connection between carcinogenesis, cancer progression, and aging. Existing models, however, are traditionally focused only on one of these aspects of health deterioratio ...
Full textCite
Journal articlePhysics Letters Section B Nuclear Elementary Particle and High Energy Physics · February 9, 2009
The contribution of exclusive radiative tail to the cross section of semi-inclusive hadron leptoproduction has been calculated exactly for the first time. Although the experience of inclusive data analyses suggests us that the contribution of radiative tai ...
Full textCite
Journal articleComputational and Mathematical Methods in Medicine · January 1, 2009
Linear latent structure analysis is a new approach for investigation of population heterogeneity using high-dimensional categorical data. In this approach, the population is represented by a distribution of latent vectors, which play the role of heterogene ...
Full textCite
Journal articleMechanisms of ageing and development · January 2009
The potential gain in life expectancy which could result from the complete elimination of mortality from cancer in the U.S. would not exceed 3 years if one were to consider cancer independently of other causes of death. In this paper, we review evidence of ...
Full textCite
Journal article · December 1, 2008
Age patterns of incidence rates of major circulatory diseases (CDs), their time trends, risk factors, and other characteristics capable of contributing to the debates on the role of aging in the deterioration of human health are investigated using standard ...
Full textCite
Journal articleMathematical Population Studies · July 1, 2008
An analysis using the 1982-1999 National Long-term Care Survey (NLTCS) linked to Medicare vital statistics data 1982-2003 focused on deaths at ages 85+ where deviations from the Gompertz mortality function are often observed. To model the complex mortality ...
Full textCite
Journal articleMechanisms of ageing and development · April 2008
An important feature of aging-related deterioration in human health is the decline in organisms' resistance to stresses, which contributes to an increase in morbidity and mortality risks. In human longitudinal studies of aging, such a decline is not measur ...
Full textCite
Journal articleTheoretical population biology · February 2008
Variables measured in longitudinal studies of aging and longevity do not exhaust the list of all factors affecting health and mortality transitions. Unobserved factors generate hidden variability in susceptibility to diseases and death in populations and i ...
Full textCite
Journal articleJournal of the American Geriatrics Society · January 2008
ObjectivesTo investigate the relationship between body mass index (BMI) and 9-year mortality in older (> or = 65) Americans with and without disability.DesignCohort study.SettingThe unique disability-focused National Long Term Ca ...
Full textCite
Journal articleExperimental gerontology · October 2007
Cross-sectional analyses show that an index of aging-associated health/well-being deficits, called the "frailty index", can characterize the aging process in humans. This study provides support for such characterization from a longitudinal analysis of the ...
Full textCite
Journal articleMathematical biosciences · August 2007
Aging-related changes in a human organism follow dynamic regularities, which contribute to the observed age patterns of incidence and mortality curves. An organism's 'optimal' (normal) physiological state changes with age, affecting the values of risks of ...
Full textCite
Journal articleJournal of the American Geriatrics Society · June 2007
ObjectivesTo describe the accumulation of aging-associated health disorders using a cumulative measure known as a frailty index (FI) and to evaluate its ability to differentiate long- and short-life phenotypes as well as the FI's connection to agi ...
Full textCite
Journal articleBiogerontology · June 2007
The deterioration of human health with age is manifested in changes of thousands of physiological and biological variables. The contribution of some of such changes to the mortality risk may be small and cannot be reliably detected by existing statistical ...
Full textCite
Journal articleRisk Anal · April 2007
A microsimulation model, allowing one to forecast short- and long-term population changes conditional on the prevalence of a risk factor in a population, is presented. In this model, population changes result from the aggregation of changes in individual e ...
Full textLink to itemCite
Journal articleMechanisms of ageing and development · March 2007
BackgroundWe employ an approach based on the elaborated frailty index (FI), which is capable of taking into account variables with mild effect on the aging, health and survival outcomes, and investigate the connections between the FI, chronologica ...
Full textCite
Journal articleRejuvenation research · March 2007
The composite index constructed from longitudinal survey data as the level of deficits accumulated by an individual (frailty index) captures important systemic aspects of deterioration in a human organism, and is an attractive candidate for studying determ ...
Full textCite
Journal articleStatistical Methodology · January 1, 2007
A new method for analyzing high-dimensional categorical data, Linear Latent Structure (LLS) analysis, is presented. LLS models belong to the family of latent structure models, which are mixture distribution models constrained to satisfy the local independe ...
Full textCite
Journal articleAge (Dordrecht, Netherlands) · December 2006
Age trajectories of physiological indices contain important information about aging-related changes in the human organism and therefore may help us understand human longevity. The goal of this study is to investigate whether shapes of such trajectories ear ...
Full textCite
Journal articleMechanisms of ageing and development · November 2006
BackgroundAn index of age-associated health/well-being disorders (deficits), called the "frailty index" (FI), appears to be a promising characteristic to capture dynamic variability in aging manifestations among age-peers. In this study we provide ...
Full textCite
Journal articleRadiats Biol Radioecol · 2006
In this paper we review recently-developed extension frailty, quadratic hazard, stochastic process, microsimulation, and linear latent structure models, which have the potential to describe the health effects of human populations exposed to ionizing radiat ...
Link to itemCite
Journal articleRadiats Biol Radioecol · 2006
Efforts to model the health effects of low-dose ionizing radiation (IR) have often focused on cancer. Meanwhile, significant evidence links IR and age-associated non-cancer diseases. Modeling of such complex processes, which are not currently well understo ...
Link to itemCite
Journal articleScience of aging knowledge environment : SAGE KE · June 2005
Much of the increased risk for atherosclerosis progression with age may be a result of age-related declines in the capacity of precursor cells to repair damage in the arterial endothelium. To estimate the impact of progenitor cell therapy for atheroscleros ...
Full textCite
Journal articleMathematical Population Studies · April 1, 2005
Life table models based on nonlinear dynamics of risk factors are developed using stochastic differential equations for individual changes and on the resulting Fokker-Planck equation to describe population changes. Central to the model is a microsimulation ...
Full textCite
Journal articleJournal of Biological Systems · December 1, 2004
We present two models suitable for describing dynamics of a population of unicellular organisms residing in chemostat. These models are based on biologically motivated Dynamic Energy Budget (DEB) theory and take into account the dynamics of mean energy res ...
Full textCite
Journal articleFrontiers in bioscience : a journal and virtual library · September 2004
The health effects of ionizing radiation on human populations are often analyzed using epidemiological statistical methods. Because of the complexity of the health consequences of ionizing radiation and the prolonged period during which the consequences em ...
Full textCite
Journal articleJournal of Experimental and Theoretical Physics · March 1, 2004
The electron structure function method is applied to calculate model-independent QED radiative corrections to the asymmetry of electron-proton scattering. Representations for both spin-independent and spin-dependent parts of the cross section are derived. ...
Full textCite
Journal articleFrontiers in bioscience : a journal and virtual library · January 2004
Despite the wealth of longitudinal data on the health dynamics of human populations, information on covariates (risk factors) changes in those studies has not been systematically and fully exploited. In this work we use the 46-year follow-up of the Framing ...
Full textCite
Journal articlePhysical Review D · December 1, 2002
Using a method of electron structure functions, we calculated a model independent radiative correction to the recoil proton polarization for elastic electron-proton scattering. Explicit expressions for the recoil proton polarization are represented as a co ...
Full textCite
Journal articlePhysical Review D Particles Fields Gravitation and Cosmology · January 1, 2002
A formalism for radiative correction (RC) calculation in exclusive pion electroproduction on the proton is presented. A FORTRAN code EXCLURAD is developed for the RC procedure. The numerical analysis is done in the kinematics of current Jefferson Lab exper ...
Full textCite
Journal articlePhysics of Particles and Nuclei · December 1, 2001
The present status of the theoretical description of the deep inelastic scattering of leptons off protons with account for radiative corrections (RCs) in the leading and next-to-leading approximations are reviewed. For the process ep → epγ along with RC co ...
Cite
Journal articlePhysical Review D · December 1, 2001
Explicit formulas for radiative correction (RC) calculations for elastic ep scattering are presented. Two typical measurements of polarization observables, such as beam-target asymmetry or recoil proton polarization, are considered. The possibilities of ta ...
Full textCite
Journal articleZhurnal Eksperimental Noj I Teoreticheskoj Fiziki · December 1, 2001
We completely analyze the model-independent leading radiative corrections to the cross-section and polarization observables in the semi-inclusive deep-inelastic electron-nucleus scattering with the detection of a proton and the scattered electron in coinci ...
Cite
Journal articlePhysical Review D · November 1, 2001
For the kinematical region when a hard photon is emitted predominantly close to the direction of motion of a longitudinally polarized initial electron and relatively small momentum is transferred to a proton we calculate the azimuthal asymmetry of photon e ...
Cite
Journal articlePhysical Review D · November 1, 2001
For the kinematical region when a hard photon is emitted predominantly close to the direction of motion of a longitudinally polarized initial electron and relatively small momentum is transferred to a proton we calculate the azimuthal asymmetry of photon e ...
Cite
Journal articlePhysics Letters Section B Nuclear Elementary Particle and High Energy Physics · August 16, 2001
Compact analytical formulae for QED radiative corrections in the processes of elastic e-p scattering are obtained in the case when kinematic variables are reconstructed from the recoil proton momentum measured. Numerical analysis is presented under kinemat ...
Full textCite
Journal articleJournal of Experimental and Theoretical Physics · January 1, 2001
We completely analyze the model-independent leading radiative corrections to the cross section and polarization observables in the semi-inclusive deep-inelastic electron-nucleus scattering with the detection of a proton and the scattered electron in coinci ...
Full textCite
Journal articleEuropean Physical Journal C · January 1, 2001
The influence of the nuclear medium on the production of charged hadrons in semi-inclusive deep-inelastic scattering has been studied by the HERMES experiment at DESY using a 27.5 GeV positron beam. The differential multiplicity of charged hadrons and iden ...
Full textCite
Journal articlePhysics Letters Section B Nuclear Elementary Particle and High Energy Physics · November 23, 2000
The dependence on Q2 (the negative square of the 4-momentum of the exchanged virtual photon) of the generalised Gerasimov-Drell-Hearn integral for the proton has been measured in the range 1.2 GeV2 < Q2 < 12 GeV2 ...
Full textCite
Journal articleJournal of Physics G Nuclear and Particle Physics · September 1, 2000
The contribution of the radiative tail from the quasielastic peak to low-order radiative correction to deep inelastic scattering of polarized leptons by polarized 3He is calculated within the sum-rules formalism and y-scaling hypothesis. A numer ...
Full textCite
Journal articlePhysics Letters Section B Nuclear Elementary Particle and High Energy Physics · February 17, 2000
QED radiative effects are considered in the case of the measurement of spin-density matrix elements of diffractive ρ-meson electroproduction. Large radiative correction for r00/5 is found in the kinematics of collider experiments at H ...
Full textCite
Journal articleEuropean Physical Journal C · January 1, 2000
Measurements of the cross section for exclusive virtual-photoproduction of ρ0 mesons from hydrogen are reported. The data were collected by the HERMES experiment using 27.5 GeV positrons incident on a hydrogen gas target in the HERA storage ring ...
Full textCite
Journal articlePhysical Review A Atomic Molecular and Optical Physics · January 1, 2000
The process of electron-positron pair production by linearly polarized photons may be used as a polarimeter to perform mobile measurement of linear photon polarization. In the limit of high photon energies ω the distributions of the recoil-electron momentu ...
Cite
Journal articlePhysical Review A Atomic Molecular and Optical Physics · January 1, 2000
The process of electron-positron pair production by linearly polarized photons may be used as a polarimeter to perform mobile measurement of linear photon polarization. In the limit of high photon energies ω the distributions of the recoil-electron momentu ...
Full textCite
Journal articlePhysical Review D - Particles, Fields, Gravitation and Cosmology · January 1, 2000
We calculate the deep inelastic scattering (DIS) cross section under kinematical requirements when a final hadron state is a single proton. The process in the lowest order is known as the radiative tail from the elastic peak. We take into account the corre ...
Full textCite
Journal articleEuropean Physical Journal C · January 1, 1999
The electromagnetic radiative correction to the cross section of the vector meson electroproduction is calculated. Explicit covariant formulae for the observed cross section are obtained. The dependence of the radiative correction on the experimental resol ...
Full textCite
Journal articleEuropean Physical Journal C · January 1, 1999
An approach to calculate radiative corrections to the unpolarized cross section of semi-inclusive electroproduction is developed. Explicit formulae for the lowest order QED radiative correction are presented. A detailed numerical analysis is performed with ...
Full textCite
Journal articlePhysics Letters Section B Nuclear Elementary Particle and High Energy Physics · January 1, 1999
The measurement of the polarized gluon distribution function ΔG / G using current-target correlations in the Breit frame of deep inelastic scattering is proposed. The approach is illustrated using a Monte Carlo simulation of polarized ep-collisions for HER ...
Full textCite
Journal articleEuropean Physical Journal C · January 1, 1999
Within the framework of a simple model, we study single-spin asymmetries for pion production in hadron-hadron collisions at high energies with one hadron polarized. The asymmetries are generated via a mechanism of final-(initial-) state interactions. For p ...
Full textCite
Journal articlePhysics Letters Section B Nuclear Elementary Particle and High Energy Physics · January 1, 1999
Spin asymmetries of semi-inclusive cross sections for the production of positively and negatively charged hadrons have been measured in deep-inelastic scattering of polarized positrons on polarized hydrogen and He targets, in the kinematic range 0.023 < x ...
Full textCite
Journal articlePhysical Review Letters · January 1, 1999
Exclusive incoherent electroproduction of the ρ0(770) meson from 1H, 2H, 3He, and 14N targets has been studied by the HERMES experiment at squared four-momentum transfer Q2 > 0.4GeV2
Full textCite
Journal articlePhysics Letters Section B Nuclear Elementary Particle and High Energy Physics · December 24, 1998
The virtual photon absorption cross section differences [σ1/2 - σ3/2] for the proton and neutron have been determined from measurements of polarised cross section asymmetries in deep inelastic scattering of 27.5 GeV longitudinally pol ...
Full textCite
Journal articlePhysics Letters Section B Nuclear Elementary Particle and High Energy Physics · December 3, 1998
A measurement of the proton spin structure function g1p(x,Q2) in deep-inelastic scattering is presented. The data were taken with the 27.6 GeV longitudinally polarised positron beam at HERA incident on a longitudinally pola ...
Full textCite
Journal articleJournal of Physics G Nuclear and Particle Physics · December 1, 1998
Two possible schemes of the radiative correction procedure are discussed. The sources of the systematic uncertainties due to the radiative correction procedure in the measurements of the structure function gn1 with 3He targ ...
Full textCite
Journal articlePhysics of Atomic Nuclei · December 1, 1998
Model-independent radiative corrections of orders α, αL, and α2L2 to the lepton current for the deep-inelastic scattering of polarized leptons on light polarized nuclei have been obtained. The computational method employed is briefly ...
Cite
Journal articleJournal of Physics G Nuclear and Particle Physics · November 1, 1998
The one-loop electroweak radiative correction of the lowest order to lepton current for deep inelastic scattering of longitudinally polarized leptons by polarized nucleons is obtained in a model-independent way. Detailed numerical analysis within the kinem ...
Full textCite
Journal articlePhysics Letters Section B Nuclear Elementary Particle and High Energy Physics · July 23, 1998
The matrix element squared for Compton scattering of a heavy photon on a longitudinally polarized electron is calculated. Assuming that all kinematical invariants and the invariant mass of the heavy photon are large in comparison with the electron mass, th ...
Full textCite
Journal articleNuclear Instruments and Methods in Physics Research Section A Accelerators Spectrometers Detectors and Associated Equipment · June 21, 1998
A new method to extract asymmetries and spin-dependent structure functions is proposed. The method is based on the exact formulae for differences of cross-sections of deep inelastic scattering of polarised leptons on polarised nucleons with different orien ...
Full textCite
Journal articlePhysical Review Letters · January 1, 1998
The flavor asymmetry of the light quark sea of the nucleon is determined in the kinematic range 0.02 < x < 0.3 and 1 < Q2 < 10GeV2 for the first time from semi-inclusive deep-inelastic scattering. The quantity [d¯(x)- ¯u(x)]/[u(x)-d(x ...
Full textCite
Journal articlePhysics Letters Section B Nuclear Elementary Particle and High Energy Physics · July 10, 1997
Results are reported from the HERMES experiment at HERA on a measurement of the neutron spin structure function gn1(x, Q2) in deep inelastic scattering using 27.5 GeV longitudinally polarized positrons incident on a polariz ...
Full textCite
Journal articleComputer Physics Communications · January 1, 1997
The FORTRAN code POLRAD 2.0 for radiative correction calculation in inclusive and semi-inclusive deep inelastic scattering of polarized leptons by polarized nucleons and nuclei is described. Its theoretical basis, structure and algorithms are discussed in ...
Full textCite
Journal articleJournal of Physics G Nuclear and Particle Physics · December 1, 1994
Principal contributions to QED radiative effects in deep inelastic scattering (DIS) of polarized leptons by polarized targets (H,D,3He) are investigated both on the Born level and taking into account radiative corrections (RC). Scattering in the ...
Full textCite
Journal articleJournal of Physics G Nuclear and Particle Physics · December 1, 1992
The authors obtain the formulae for the invariant inclusive cross section of the elastic radiative tail and other observables which shall be measured in forthcoming lepton-nucleon experiments. Taking into account the parameters of these experiments a reali ...
Full textCite
