Scholars@Duke
Irma Husain

Irma Husain

Assistant Professor of Medicine
Medicine, Nephrology

Scholarly Works

Whole-Body Functional and Molecular Imaging by Integrated Photoacoustic and Ultrasound Imaging

Conference Proceedings of SPIE the International Society for Optical Engineering · March 5, 2026 The complexity of biomedical research, particularly studies of brain activity, the tumor microenvironment, and aging, demands imaging technologies capable of concurrently revealing multiple aspects of tissue pathology and physiology. Traditional single-mod ... Full text Cite

Targeting allograft inflammatory factor 1 reprograms kidney macrophages to enhance repair.

Journal article J Clin Invest · January 21, 2025 The role of macrophages (MΦs) remains incompletely understood in kidney injury and repair. The plasticity of MΦs offers an opportunity to polarize them toward mediating injury resolution in both native and transplanted kidneys undergoing ischemia and/or re ... Full text Link to item Cite

Murine kidney transplant outcome is best measured by transdermal glomerular filtration rate.

Journal article Am J Transplant · December 2024 Mouse kidney transplantation provides a powerful preclinical model for the study of kidney transplant alloimmunity. However, accurate measurement of graft function is difficult because of the inaccuracy of traditional surrogate markers serum creatinine and ... Full text Link to item Cite

AXL inhibition suppresses early allograft monocyte-to-macrophage differentiation and prolongs allograft survival.

Conference JCI Insight · March 8, 2024 Innate immune cells are important in the initiation and potentiation of alloimmunity in transplantation. Immediately upon organ anastomosis and reperfusion, recipient monocytes enter the graft from circulation and differentiate to inflammatory macrophages ... Full text Link to item Cite

Novel Approaches to Immunomodulation for Solid Organ Transplantation.

Journal article Annu Rev Med · January 29, 2024 Despite significant advances in the field of transplantation in the past two decades, current clinically available therapeutic options for immunomodulation remain fairly limited. The advent of calcineurin inhibitor-based immunosuppression has led to signif ... Full text Link to item Cite

Research Highlights

Journal article Transplantation · November 2023 Full text Cite

Blocking CCL8-CCR8-Mediated Early Allograft Inflammation Improves Kidney Transplant Function.

Journal article J Am Soc Nephrol · October 2022 BACKGROUND: In kidney transplantation, early allograft inflammation impairs long-term allograft function. However, precise mediators of early kidney allograft inflammation are unclear, making it challenging to design therapeutic interventions. METHODS: We ... Full text Open Access Link to item Cite

Research Highlights

Journal article Transplantation · March 1, 2022 Full text Cite

Apoptotic Donor Cells in Transplantation.

Journal article Front Immunol · 2021 Despite significant advances in prevention and treatment of transplant rejection with immunosuppressive medications, we continue to face challenges of long-term graft survival, detrimental medication side effects to both the recipient and transplanted orga ... Full text Link to item Cite

Single cell transcriptomics of mouse kidney transplants reveals a myeloid cell pathway for transplant rejection.

Journal article JCI insight · October 2020 Myeloid cells are increasingly recognized as major players in transplant rejection. Here, we used a murine kidney transplantation model and single cell transcriptomics to dissect the contribution of myeloid cell subsets and their potential signaling pathwa ... Full text Open Access Cite

Research Highlights

Journal article Transplantation · July 1, 2020 Full text Cite

Proteinuric Kidney Diseases: A Podocyte's Slit Diaphragm and Cytoskeleton Approach.

Journal article Front Med (Lausanne) · 2018 Proteinuric kidney diseases are a group of disorders with diverse pathological mechanisms associated with significant losses of protein in the urine. The glomerular filtration barrier (GFB), comprised of the three important layers, the fenestrated glomerul ... Full text Link to item Cite

Role of androgen receptor in prostatic neoplasia versus hyperplasia.

Journal article J Cancer Res Ther · 2016 INTRODUCTION: Androgens play a fundamental role in the growth, differentiation, and maintenance of prostate tissue. The objective of the study was to evaluate and compare the androgen receptor (AR) expression in benign prostatic hyperplasia (BPH), prostati ... Full text Link to item Cite

CSF norepinephrine in cerebrovascular accidents.

Journal article Indian J Med Res · November 1978 Link to item Cite