Jeffrey Nicholas Browndyke

Journal article Br J Anaesth · December 2021 Featured Publication BACKGROUND: Cognitive dysfunction after surgery is a major issue in older adults. Here, we determined the effect of APOE4 on perioperative neurocognitive function in older patients. METHODS: We enrolled 140 English-speaking patients ≥60 yr old scheduled fo ... Full text Open Access Link to item Cite

Identification of MCI individuals using structural and functional connectivity networks.

Journal article Neuroimage · February 1, 2012 Featured Publication Different imaging modalities provide essential complementary information that can be used to enhance our understanding of brain disorders. This study focuses on integrating multiple imaging modalities to identify individuals at risk for mild cognitive impa ... Full text Link to item Cite

Enriched white matter connectivity networks for accurate identification of MCI patients.

Journal article Neuroimage · February 1, 2011 Featured Publication Mild cognitive impairment (MCI), often a prodromal phase of Alzheimer's disease (AD), is frequently considered to be a good target for early diagnosis and therapeutic interventions of AD. Recent emergence of reliable network characterization techniques has ... Full text Link to item Cite

Factor structure of the National Alzheimer's Coordinating Centers uniform dataset neuropsychological battery: an evaluation of invariance between and within groups over time.

Journal article Alzheimer Dis Assoc Disord · 2011 Featured Publication The neuropsychological battery from the National Alzheimer's Disease Coordinating Center is designed to provide a sensitive assessment of mild cognitive disorders for multicenter investigations. Comprising 8 common neuropsychological tests (12 measures), t ... Full text Link to item Cite

Validation of the coin rotation test: a simple, inexpensive, and convenient screening tool for impaired psychomotor processing speed.

Journal article Neurologist · July 2010 Featured Publication OBJECTIVES: The Coin Rotation Test is a simple, convenient, and cost-effective measure of psychomotor processing speed that has been used in neurologic examinations at the Louisiana State University Health Sciences system for almost 20 years. On the Coin R ... Full text Link to item Cite

Temporal lobe functional activity and connectivity in young adult APOE varepsilon4 carriers.

Journal article Alzheimers Dement · July 2010 Featured Publication BACKGROUND: We sought to determine if the APOE epsilon4 allele influences both the functional activation and connectivity of the medial temporal lobes (MTLs) during successful memory encoding in young adults. METHODS: Twenty-four healthy young adults, i.e. ... Full text Link to item Cite

Effects of the dietary approaches to stop hypertension diet, exercise, and caloric restriction on neurocognition in overweight adults with high blood pressure.

Journal article Hypertension · June 2010 Featured Publication High blood pressure increases the risks of stroke, dementia, and neurocognitive dysfunction. Although aerobic exercise and dietary modifications have been shown to reduce blood pressure, no randomized trials have examined the effects of aerobic exercise co ... Full text Open Access Link to item Cite

Aerobic exercise and neurocognitive performance: a meta-analytic review of randomized controlled trials.

Journal article Psychosom Med · April 2010 Featured Publication OBJECTIVES: To assess the effects of aerobic exercise training on neurocognitive performance. Although the effects of exercise on neurocognition have been the subject of several previous reviews and meta-analyses, they have been hampered by methodological ... Full text Open Access Link to item Cite

Genetic regulation of alpha-synuclein mRNA expression in various human brain tissues.

Journal article PLoS One · October 16, 2009 Featured Publication Genetic variability across the SNCA locus has been repeatedly associated with susceptibility to sporadic Parkinson's disease (PD). Accumulated evidence emphasizes the importance of SNCA dosage and expression levels in PD pathogenesis. However whether genet ... Full text Link to item Cite

Neuroanatomical correlates of malingered memory impairment: event-related fMRI of deception on a recognition memory task.

Journal article Brain Inj · June 2008 Featured Publication PRIMARY OBJECTIVE: Event-related, functional magnetic resonance imaging (fMRI) data were acquired in healthy participants during purposefully malingered and normal recognition memory performances to evaluate the neural substrates of feigned memory impairme ... Full text Link to item Cite

FMRI correlates of the WAIS-III symbol search subtest.

Journal article J Int Neuropsychol Soc · July 2005 Featured Publication Functional magnetic resonance imaging (FMRI) experiments frequently administer substantially adapted cognitive tests. This study was designed to identify FMRI correlates of a well-standardized clinical measure presented with minor adaptations. We administe ... Full text Link to item Cite

Perfusion abnormalities and decision making in cocaine dependence.

Journal article Biol Psychiatry · October 1, 2004 Featured Publication BACKGROUND: Previous studies have shown that cocaine abusers have cerebral perfusion deficits that may diminish cognitive functioning. This study examined whether cocaine-dependent patients have perfusion abnormalities associated with poor decision-making ... Full text Link to item Cite

The neuropsychological profile of vascular cognitive impairment--no dementia: comparisons to patients at risk for cerebrovascular disease and vascular dementia.

Journal article Arch Clin Neuropsychol · September 2004 Featured Publication Hachinski and co-workers have used the term vascular cognitive impairment-no dementia (VaCIND) to represent the earliest stages of cognitive decline associated with vascular changes [Neurology 57 (4) (2001) 714]. However, the neuropsychological profile of ... Full text Link to item Cite

Gender-specific vulnerability for rCBF abnormalities among cocaine abusers.

Journal article Neuroreport · April 9, 2004 Featured Publication Fifty abstinent cocaine-dependent patients and 20 healthy controls were evaluated with 99mTc-HMPAO SPECT to examine gender differences in perfusion. Group contrasts with statistical parametric mapping revealed male and female patients exhibited not only di ... Full text Link to item Cite

Examining the effect of cerebral perfusion abnormality magnitude on cognitive performance in recently abstinent chronic cocaine abusers.

Journal article J Neuroimaging · April 2004 Featured Publication BACKGROUND AND PURPOSE: Cerebral perfusion abnormalities and neuropsychological impairment are common sequelae of chronic cocaine abuse. While perfusion abnormalities have been shown to relate to cognitive deficits in this substance abuse population, the r ... Link to item Cite

Neuroimaging correlates of dementia rating scale performance at baseline and 12-month follow-up among patients with vascular dementia.

Journal article J Geriatr Psychiatry Neurol · December 2003 Featured Publication The authors previously reported that subcortical hyperintensity (SH) and whole-brain volume (WBV) each covary with different subscale scores of the Mattis Dementia Rating Scale (MDRS) among vascular dementia (VaD) patients. The present longitudinal analysi ... Full text Link to item Cite

Long-term citicoline (cytidine diphosphate choline) use in patients with vascular dementia: neuroimaging and neuropsychological outcomes.

Journal article Cerebrovasc Dis · 2003 Featured Publication BACKGROUND: Cytidine diphosphate choline (citicoline) has been previously shown to have efficacy in reducing the functional impairments associated with acute stroke. Citicoline is thought to have neuroprotective benefits and has been used for the treatment ... Full text Link to item Cite

Sensitivity of the dementia rating scale in vascular dementia: comparison between two sets of criteria to define cognitive impairment.

Journal article Cerebrovasc Dis · 2003 Featured Publication BACKGROUND: The Dementia Rating Scale (DRS) is a common measure of cognitive function, but its sensitivity to identify deficits across cognitive domains in vascular dementia (VaD) remains unclear. METHODS: We compared the sensitivity and specificity of two ... Full text Link to item Cite

Acute neuropsychological functioning following cardiosurgical interventions associated with the production of intraoperative cerebral microemboli.

Journal article Clin Neuropsychol · December 2002 Featured Publication Coronary artery bypass graft (CABG) and valve replacement (VR) surgical patients underwent neuropsychological assessment 1-2 days prior to surgery; 7-10 days postsurgery; and 1 month following hospital discharge. A group of matched healthy controls was tes ... Full text Link to item Cite

Computer-related anxiety: examining the impact of technology-specific affect on the performance of a computerized neuropsychological assessment measure.

Journal article Appl Neuropsychol · 2002 Featured Publication This study was conducted to examine the effect of impairment status and computer-specific anxiety on the performance of a computerized neuropsychological assessment measure. Computer related anxiety was measured using a standardized self-report measure tap ... Full text Link to item Cite