Joshua Clair Snyder
Associate Professor in Surgery
I am the PI of the Cancer Initiation and Cancer Cell Behavior lab. Our research objective is to determine how cancer cells adapt and grow before cancer is diagnosed. Our lab is also part of the Center for Applied therapeutics where we share our models as tools for preclinical and translational research. To learn more about our research please visit the Cancer Initiation and Cancer Cell Behavior Lab's homepage.
Current Appointments & Affiliations
- Associate Professor in Surgery, Surgery, Surgical Sciences, Surgery 2023
- Associate Professor of Cell Biology, Cell Biology, Basic Science Departments 2022
- Associate Professor in Pharmacology and Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2022
- Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2017
Contact Information
- 203 Research Drive, Msrb1 475A, DUMC 2606, Durham, NC 27710
- Msrbi Rm 475A, Durham, NC 27710
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joshua.snyder@duke.edu
(919) 684-3162
- Background
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Education, Training, & Certifications
- Ph.D., University of Pittsburgh, School of Medicine 2009
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Previous Appointments & Affiliations
- Associate Professor in Surgery, Surgery, Surgical Sciences, Surgery 2022 - 2023
- Assistant Professor of Surgery, Surgery, Surgical Sciences, Surgery 2017 - 2022
- Assistant Professor of Cell Biology, Cell Biology, Basic Science Departments 2018 - 2022
- Assistant Research Professor of Cell Biology, Cell Biology, Basic Science Departments 2015 - 2018
- Assistant Professor in Surgery, Surgery, Surgical Sciences, Surgery 2016 - 2017
- Recognition
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In the News
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DEC 2, 2019 Duke Health News
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- Research
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Selected Grants
- Medical Scientist Training Program awarded by National Institutes of Health 2022 - 2027
- Training Program in Developmental and Stem Cell Biology awarded by National Institutes of Health 2001 - 2027
- Cell and Molecular Biology Training Program awarded by National Institutes of Health 2021 - 2026
- Visualizing tumor heterogeneity in an immune intact and autochthonous mouse model of breast cancer awarded by National Institutes of Health 2021 - 2026
- Therapeutic targeting of breast cancer and host immune responses at inflection points in the disease trajectory awarded by Department of Defense 2021 - 2025
- Mouse Paint: A massively combinatorial approach for illuminating tumor heterogeneity in True Color awarded by National Institutes of Health 2022 - 2025
- Recording the natural history of cancer progression using a Crainbow model of HER2+ breast cancer awarded by Icahn School of Medicine at Mount Sinai 2022 - 2024
- Establishing the molecular and cellular mechanisms of Lgr5 signaling for controlling cancer stem cell behavior awarded by National Institutes of Health 2017 - 2021
- Only the strong survive: Microenvironmental and genetic determinants of organotropism awarded by Sage Bionetworks 2017 - 2018
- A Cancer Rainbow Mouse for Simultaneous Assessment of Multiple Oncogenes awarded by National Institutes of Health 2015 - 2018
- Beta-catenin modulates dopamine dependent signal transduction and behavior. awarded by National Institutes of Health 2011 - 2013
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External Relationships
- 10x Genomics Inc.
- Adanate, Inc.
- Precisonary Instruments, LLC
- Tisch Cancer Institute
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Adler, Frederick R., Alexander R. A. Anderson, Abhinav Bhushan, Paul Bogdan, Jose Javier Bravo-Cordero, Amy Brock, Yun Chen, et al. “Modeling collective cell behavior in cancer: Perspectives from an interdisciplinary conversation.” Cell Syst 14, no. 4 (April 19, 2023): 252–57. https://doi.org/10.1016/j.cels.2023.03.002.Full Text Link to Item
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Other Articles
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Ginzel, Joshua D., Chaitanya R. Acharya, Veronica Lubkov, Hidetoshi Mori, Peter G. Boone, Lauren K. Rochelle, Wendy L. Roberts, et al. “Supplementary Figure 6 from HER2 Isoforms Uniquely Program Intratumor Heterogeneity and Predetermine Breast Cancer Trajectories During the Occult Tumorigenic Phase,” April 3, 2023. https://doi.org/10.1158/1541-7786.22526387.Full Text
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Ginzel, Joshua D., Chaitanya R. Acharya, Veronica Lubkov, Hidetoshi Mori, Peter G. Boone, Lauren K. Rochelle, Wendy L. Roberts, et al. “Supplementary Figure 5 from HER2 Isoforms Uniquely Program Intratumor Heterogeneity and Predetermine Breast Cancer Trajectories During the Occult Tumorigenic Phase,” April 3, 2023. https://doi.org/10.1158/1541-7786.22526390.v1.Full Text
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Ginzel, Joshua D., Chaitanya R. Acharya, Veronica Lubkov, Hidetoshi Mori, Peter G. Boone, Lauren K. Rochelle, Wendy L. Roberts, et al. “Supplementary Figure 1 from HER2 Isoforms Uniquely Program Intratumor Heterogeneity and Predetermine Breast Cancer Trajectories During the Occult Tumorigenic Phase,” April 3, 2023. https://doi.org/10.1158/1541-7786.22526402.Full Text
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Ginzel, Joshua D., Chaitanya R. Acharya, Veronica Lubkov, Hidetoshi Mori, Peter G. Boone, Lauren K. Rochelle, Wendy L. Roberts, et al. “Movie 1 from HER2 Isoforms Uniquely Program Intratumor Heterogeneity and Predetermine Breast Cancer Trajectories During the Occult Tumorigenic Phase,” April 3, 2023. https://doi.org/10.1158/1541-7786.22526420.Full Text
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Ginzel, Joshua D., Chaitanya R. Acharya, Veronica Lubkov, Hidetoshi Mori, Peter G. Boone, Lauren K. Rochelle, Wendy L. Roberts, et al. “Movie 3 from HER2 Isoforms Uniquely Program Intratumor Heterogeneity and Predetermine Breast Cancer Trajectories During the Occult Tumorigenic Phase,” April 3, 2023. https://doi.org/10.1158/1541-7786.22526414.Full Text
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Ginzel, Joshua D., Chaitanya R. Acharya, Veronica Lubkov, Hidetoshi Mori, Peter G. Boone, Lauren K. Rochelle, Wendy L. Roberts, et al. “Supplementary File 1 from HER2 Isoforms Uniquely Program Intratumor Heterogeneity and Predetermine Breast Cancer Trajectories During the Occult Tumorigenic Phase,” April 3, 2023. https://doi.org/10.1158/1541-7786.22526381.v1.Full Text
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Ginzel, Joshua D., Chaitanya R. Acharya, Veronica Lubkov, Hidetoshi Mori, Peter G. Boone, Lauren K. Rochelle, Wendy L. Roberts, et al. “Movie 4 from HER2 Isoforms Uniquely Program Intratumor Heterogeneity and Predetermine Breast Cancer Trajectories During the Occult Tumorigenic Phase,” April 3, 2023. https://doi.org/10.1158/1541-7786.22526411.v1.Full Text
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Ginzel, Joshua D., Chaitanya R. Acharya, Veronica Lubkov, Hidetoshi Mori, Peter G. Boone, Lauren K. Rochelle, Wendy L. Roberts, et al. “Supplementary Figure 1 from HER2 Isoforms Uniquely Program Intratumor Heterogeneity and Predetermine Breast Cancer Trajectories During the Occult Tumorigenic Phase,” April 3, 2023. https://doi.org/10.1158/1541-7786.22526402.v1.Full Text
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Ginzel, Joshua D., Chaitanya R. Acharya, Veronica Lubkov, Hidetoshi Mori, Peter G. Boone, Lauren K. Rochelle, Wendy L. Roberts, et al. “Supplementary Figure 7 from HER2 Isoforms Uniquely Program Intratumor Heterogeneity and Predetermine Breast Cancer Trajectories During the Occult Tumorigenic Phase,” April 3, 2023. https://doi.org/10.1158/1541-7786.22526384.v1.Full Text
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Ginzel, Joshua D., Chaitanya R. Acharya, Veronica Lubkov, Hidetoshi Mori, Peter G. Boone, Lauren K. Rochelle, Wendy L. Roberts, et al. “Movie 5 from HER2 Isoforms Uniquely Program Intratumor Heterogeneity and Predetermine Breast Cancer Trajectories During the Occult Tumorigenic Phase,” April 3, 2023. https://doi.org/10.1158/1541-7786.22526405.v1.Full Text
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Ginzel, Joshua D., Chaitanya R. Acharya, Veronica Lubkov, Hidetoshi Mori, Peter G. Boone, Lauren K. Rochelle, Wendy L. Roberts, et al. “Supplementary Figure 7 from HER2 Isoforms Uniquely Program Intratumor Heterogeneity and Predetermine Breast Cancer Trajectories During the Occult Tumorigenic Phase,” April 3, 2023. https://doi.org/10.1158/1541-7786.22526384.Full Text
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Ginzel, Joshua D., Chaitanya R. Acharya, Veronica Lubkov, Hidetoshi Mori, Peter G. Boone, Lauren K. Rochelle, Wendy L. Roberts, et al. “Supplementary Figure 4 from HER2 Isoforms Uniquely Program Intratumor Heterogeneity and Predetermine Breast Cancer Trajectories During the Occult Tumorigenic Phase,” April 3, 2023. https://doi.org/10.1158/1541-7786.22526393.Full Text
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Ginzel, Joshua D., Chaitanya R. Acharya, Veronica Lubkov, Hidetoshi Mori, Peter G. Boone, Lauren K. Rochelle, Wendy L. Roberts, et al. “Supplementary Figure 6 from HER2 Isoforms Uniquely Program Intratumor Heterogeneity and Predetermine Breast Cancer Trajectories During the Occult Tumorigenic Phase,” April 3, 2023. https://doi.org/10.1158/1541-7786.22526387.v1.Full Text
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Ginzel, Joshua D., Chaitanya R. Acharya, Veronica Lubkov, Hidetoshi Mori, Peter G. Boone, Lauren K. Rochelle, Wendy L. Roberts, et al. “Movie 2 from HER2 Isoforms Uniquely Program Intratumor Heterogeneity and Predetermine Breast Cancer Trajectories During the Occult Tumorigenic Phase,” April 3, 2023. https://doi.org/10.1158/1541-7786.22526417.v1.Full Text
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Ginzel, Joshua D., Chaitanya R. Acharya, Veronica Lubkov, Hidetoshi Mori, Peter G. Boone, Lauren K. Rochelle, Wendy L. Roberts, et al. “Supplementary Figure 2 from HER2 Isoforms Uniquely Program Intratumor Heterogeneity and Predetermine Breast Cancer Trajectories During the Occult Tumorigenic Phase,” April 3, 2023. https://doi.org/10.1158/1541-7786.22526399.Full Text
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Ginzel, Joshua D., Chaitanya R. Acharya, Veronica Lubkov, Hidetoshi Mori, Peter G. Boone, Lauren K. Rochelle, Wendy L. Roberts, et al. “Supplementary Figure 4 from HER2 Isoforms Uniquely Program Intratumor Heterogeneity and Predetermine Breast Cancer Trajectories During the Occult Tumorigenic Phase,” April 3, 2023. https://doi.org/10.1158/1541-7786.22526393.v1.Full Text
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Ginzel, Joshua D., Chaitanya R. Acharya, Veronica Lubkov, Hidetoshi Mori, Peter G. Boone, Lauren K. Rochelle, Wendy L. Roberts, et al. “Supplementary Figure 2 from HER2 Isoforms Uniquely Program Intratumor Heterogeneity and Predetermine Breast Cancer Trajectories During the Occult Tumorigenic Phase,” April 3, 2023. https://doi.org/10.1158/1541-7786.22526399.v1.Full Text
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Ginzel, Joshua D., Chaitanya R. Acharya, Veronica Lubkov, Hidetoshi Mori, Peter G. Boone, Lauren K. Rochelle, Wendy L. Roberts, et al. “Movie 4 from HER2 Isoforms Uniquely Program Intratumor Heterogeneity and Predetermine Breast Cancer Trajectories During the Occult Tumorigenic Phase,” April 3, 2023. https://doi.org/10.1158/1541-7786.22526411.Full Text
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Ginzel, Joshua D., Chaitanya R. Acharya, Veronica Lubkov, Hidetoshi Mori, Peter G. Boone, Lauren K. Rochelle, Wendy L. Roberts, et al. “Supplementary File 1 from HER2 Isoforms Uniquely Program Intratumor Heterogeneity and Predetermine Breast Cancer Trajectories During the Occult Tumorigenic Phase,” April 3, 2023. https://doi.org/10.1158/1541-7786.22526381.Full Text
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Ginzel, Joshua D., Chaitanya R. Acharya, Veronica Lubkov, Hidetoshi Mori, Peter G. Boone, Lauren K. Rochelle, Wendy L. Roberts, et al. “Supplementary Figure 3 from HER2 Isoforms Uniquely Program Intratumor Heterogeneity and Predetermine Breast Cancer Trajectories During the Occult Tumorigenic Phase,” April 3, 2023. https://doi.org/10.1158/1541-7786.22526396.Full Text
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Ginzel, Joshua D., Chaitanya R. Acharya, Veronica Lubkov, Hidetoshi Mori, Peter G. Boone, Lauren K. Rochelle, Wendy L. Roberts, et al. “Supplementary Tables 1-5 for scRNAseq marker genes from HER2 Isoforms Uniquely Program Intratumor Heterogeneity and Predetermine Breast Cancer Trajectories During the Occult Tumorigenic Phase,” April 3, 2023. https://doi.org/10.1158/1541-7786.22526378.Full Text
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Ginzel, Joshua D., Chaitanya R. Acharya, Veronica Lubkov, Hidetoshi Mori, Peter G. Boone, Lauren K. Rochelle, Wendy L. Roberts, et al. “Movie 5 from HER2 Isoforms Uniquely Program Intratumor Heterogeneity and Predetermine Breast Cancer Trajectories During the Occult Tumorigenic Phase,” April 3, 2023. https://doi.org/10.1158/1541-7786.22526405.Full Text
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Ginzel, Joshua D., Chaitanya R. Acharya, Veronica Lubkov, Hidetoshi Mori, Peter G. Boone, Lauren K. Rochelle, Wendy L. Roberts, et al. “Movie 1 from HER2 Isoforms Uniquely Program Intratumor Heterogeneity and Predetermine Breast Cancer Trajectories During the Occult Tumorigenic Phase,” April 3, 2023. https://doi.org/10.1158/1541-7786.22526420.v1.Full Text
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Ginzel, Joshua D., Chaitanya R. Acharya, Veronica Lubkov, Hidetoshi Mori, Peter G. Boone, Lauren K. Rochelle, Wendy L. Roberts, et al. “Supplementary Figure 5 from HER2 Isoforms Uniquely Program Intratumor Heterogeneity and Predetermine Breast Cancer Trajectories During the Occult Tumorigenic Phase,” April 3, 2023. https://doi.org/10.1158/1541-7786.22526390.Full Text
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Ginzel, Joshua D., Chaitanya R. Acharya, Veronica Lubkov, Hidetoshi Mori, Peter G. Boone, Lauren K. Rochelle, Wendy L. Roberts, et al. “Data from HER2 Isoforms Uniquely Program Intratumor Heterogeneity and Predetermine Breast Cancer Trajectories During the Occult Tumorigenic Phase,” April 3, 2023. https://doi.org/10.1158/1541-7786.c.6545072.v1.Full Text
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Ginzel, Joshua D., Chaitanya R. Acharya, Veronica Lubkov, Hidetoshi Mori, Peter G. Boone, Lauren K. Rochelle, Wendy L. Roberts, et al. “Movie 3 from HER2 Isoforms Uniquely Program Intratumor Heterogeneity and Predetermine Breast Cancer Trajectories During the Occult Tumorigenic Phase,” April 3, 2023. https://doi.org/10.1158/1541-7786.22526414.v1.Full Text
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Ginzel, Joshua D., Chaitanya R. Acharya, Veronica Lubkov, Hidetoshi Mori, Peter G. Boone, Lauren K. Rochelle, Wendy L. Roberts, et al. “Supplementary Tables 1-5 for scRNAseq marker genes from HER2 Isoforms Uniquely Program Intratumor Heterogeneity and Predetermine Breast Cancer Trajectories During the Occult Tumorigenic Phase,” April 3, 2023. https://doi.org/10.1158/1541-7786.22526378.v1.Full Text
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Ginzel, Joshua D., Chaitanya R. Acharya, Veronica Lubkov, Hidetoshi Mori, Peter G. Boone, Lauren K. Rochelle, Wendy L. Roberts, et al. “Supplementary Figure 3 from HER2 Isoforms Uniquely Program Intratumor Heterogeneity and Predetermine Breast Cancer Trajectories During the Occult Tumorigenic Phase,” April 3, 2023. https://doi.org/10.1158/1541-7786.22526396.v1.Full Text
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Ginzel, Joshua D., Chaitanya R. Acharya, Veronica Lubkov, Hidetoshi Mori, Peter G. Boone, Lauren K. Rochelle, Wendy L. Roberts, et al. “Movie 2 from HER2 Isoforms Uniquely Program Intratumor Heterogeneity and Predetermine Breast Cancer Trajectories During the Occult Tumorigenic Phase,” April 3, 2023. https://doi.org/10.1158/1541-7786.22526417.Full Text
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- Teaching & Mentoring
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Recent Courses
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