Scholars@Duke
Joshua Clair Snyder

Joshua Clair Snyder

Adjunct Professor in the Department of Surgery
Surgery, Surgical Sciences
203 Research Drive, MSRB1 475A, DUMC 2606, Durham, NC 27710
MSRBI Rm 475A, Durham, NC 27710

Scholarly Works - Preprints

P95-HER2 promotes metastatic progression by biasing MRTFA dependent signaling.

Preprint · July 23, 2026 Naturally occurring isoforms of the proto-oncogene Erb-B2 Receptor Tyrosine Kinase 2 (ERBB2, HER2) incite unique pathways of tumor progression in mouse models of breast cancer. Although each isoform has been shown to progress to metastasis, the N-terminall ... Full text Link to item Cite

CoSiDeX: A hyperspectral fluorescent protein resource for highly multiplexed imaging.

Preprint · May 14, 2025 Fluorescent proteins (FPs) have revolutionized spatiotemporal observations in biology. Yet, the design of multiplexed assays remains constrained by limited spectral characterization and palette validation. Although over 1,000 FPs have been catalogued, syst ... Full text Link to item Cite

Nonlinear progression during the occult transition establishes cancer lethality.

Preprint · August 12, 2024 Cancer screening is based upon a linear model of neoplastic growth and malignant progression. Yet, historical observations suggest that malignant progression is uncoupled from growth which may explain the paradoxical increase in early-stage breast cancer d ... Full text Link to item Cite