Scholars@Duke
Qingrong Jackie Wu

Qingrong Jackie Wu

Professor of Radiation Oncology
Radiation Oncology
jackie.wu@duke.edu
Box 3295 Med Ctr, Durham, NC 27710
201 Trent Drive, Box 3295, Durham, NC 27710

Scholarly Works - Journal articles

Reference-Free large language model agents for physician-guided radiotherapy treatment planning.

Journal article Med Phys · August 2026 BACKGROUND: Large language models (LLMs) have recently demonstrated exceptional capabilities, offering the potential to streamline workflows and enhance efficiency across diverse tasks. However, their application in domain-specific areas, such as radiother ... Full text Link to item Cite

Feasibility study of a machine learning inspired approach for VMAT optimization.

Journal article Med Phys · April 2026 BACKGROUND: Despite the widespread clinical adoption of volumetric modulated arc therapy (VMAT), advances in its fundamental optimization methodology have remained relatively limited, particularly with respect to open and researcher-accessible optimization ... Full text Link to item Cite

Prescription tradeoff decision support for pancreas stereotactic body radiation therapy: From templates to artificial intelligence models

Journal article Radiation Medicine and Protection · April 1, 2026 Objective: To develop an artificial intelligence (AI) driven plan tradeoff decision making assistant for radiation oncologists. Methods: A user interface (UI) was developed to integrate the assistant with the treatment planning system to facilitate prescri ... Full text Cite

Accuracy of Photon Dose Calculation on Photon-Counting Computed Tomography-A Comparison Study Based on Virtual Monoenergetic and Electron Density (Rho) Images for Pancreatic Cases.

Journal article Adv Radiat Oncol · February 2026 PURPOSE: Photon-counting computed tomography (PCCT) offers versatile anatomic information because of better energy discrimination and higher spatial resolution than conventional energy-integrating computed tomography (CT). With its rapid applications in di ... Full text Link to item Cite

Automatic lung dose painting for functional lung avoidance radiotherapy through multi-modality-guided dose prediction.

Journal article Phys Med Biol · January 9, 2026 Objective.This study aims to develop a multi-modality-guided dose prediction (MMDP)-based auto-planning algorithm for functional lung avoidance radiotherapy (FLART) guided by voxel-wise lung function images.Approach.The proposed auto-planning algorithm con ... Full text Link to item Cite

Quantitative Evaluation of Artificial Intelligence-Based Organ Segmentation Across Multiple Anatomic Sites Using 8 Commercial Software Platforms.

Journal article Pract Radiat Oncol · 2026 PURPOSE: This study aims to evaluate organs-at-risk (OARs) segmentation variability across 8 commercial artificial intelligence (AI)-based segmentation software using independent multi-institutional data sets, and to provide recommendations for clinical pr ... Full text Link to item Cite

Illusion of convergence: Search space geometry in radiotherapy treatment plan optimization.

Journal article Med Phys · January 2026 BACKGROUND: Treatment plan optimization is foundational for radiotherapy. However, the geometry of the underlying search space where feasible solutions reside remains poorly characterized. Understanding this search space is crucial as it: (1) Exposes hidde ... Full text Link to item Cite

A generalizable dose prediction model for automatic radiotherapy planning based on physics-informed priors and large-kernel convolutions.

Journal article Med Phys · January 2026 BACKGROUND: Automatic radiotherapy planning based on deep learning-based dose prediction shows promise in improving planning efficiency, consistency, and quality. However, most existing studies have focused on scenario-specific dose prediction models, ther ... Full text Link to item Cite

Foresight planning: Radiotherapy plan optimization via self-supervised model predictive control.

Journal article Med Phys · November 2025 BACKGROUND: Treatment planning for intensity-modulated radiation therapy (IMRT) and volumetric modulated arc therapy (VMAT) relies on meticulous operation of the inverse optimization, a complex and iterative process of adjusting dose-volume objectives to a ... Full text Link to item Cite

A technique for achieving arbitrary machine dose rates via MLC leaf motion modulation using fixed-gantry IMRT delivery mode.

Journal article Med Phys · June 2025 BACKGROUND: The medical linear accelerator (Linac) typically operates at a constant but discrete dose rate for both 3D conformal fields and intensity modulation radiotherapy (IMRT) fields. However, in certain clinical and radiobiological scenarios, such as ... Full text Link to item Cite

Reinforcement learning-driven automated head and neck simultaneous integrated boost (SIB) radiation therapy: flexible treatment planning aligned with clinical preferences.

Journal article Phys Med Biol · April 22, 2025 Objective.Head-and-neck simultaneous integrated boost (SIB) treatment planning using intensity modulated radiation therapy is particularly challenging due to the proximity to organs-at-risk. Depending on the specific clinical conditions, different parotid- ... Full text Link to item Cite

Quality Management for Radiation Oncology In-House Software Products.

Journal article Bioengineering (Basel) · March 29, 2025 (1) Objective: To develop and implement an in-house software quality management (ISQM) program to ensure the continuous, consistent quality of in-house software products. (2) Methods: The ISQM program consists of two key components: quality assurance (QA) ... Full text Open Access Link to item Cite

Understanding and modeling human-AI interaction of artificial intelligence tool in radiation oncology clinic using deep neural network: a feasibility study using three year prospective data.

Journal article Phys Med Biol · November 14, 2024 Objective.Artificial intelligence (AI) based treatment planning tools are being implemented in clinic. However, human interactions with such AI tools are rarely analyzed. This study aims to comprehend human planner's interaction with the AI planning tool a ... Full text Link to item Cite

Enhanced Electroacoustic Tomography with Supervised Learning for Real-time Electroporation Monitoring.

Journal article Precis Radiat Oncol · September 2024 BACKGROUND: Nanosecond pulsed electric fields (nsPEF)-based electroporation is a new therapy modality potentially synergized with radiation therapy to improve treatment outcomes. To verify its treatment accuracy intraoperatively, electroacoustic tomography ... Full text Link to item Cite

Automatic planning for functional lung avoidance radiotherapy based on function-guided beam angle selection and plan optimization.

Journal article Phys Med Biol · July 17, 2024 Objective.This study aims to develop a fully automatic planning framework for functional lung avoidance radiotherapy (AP-FLART).Approach.The AP-FLART integrates a dosimetric score-based beam angle selection method and a meta-optimization-based plan optimiz ... Full text Link to item Cite

AAPM Task Group 334: A guidance document to using radiotherapy immobilization devices and accessories in an MR environment.

Journal article Med Phys · June 2024 Use of magnetic resonance (MR) imaging in radiation therapy has increased substantially in recent years as more radiotherapy centers are having MR simulators installed, requesting more time on clinical diagnostic MR systems, or even treating with combinati ... Full text Link to item Cite

NRG Oncology Assessment of Artificial Intelligence Deep Learning-Based Auto-segmentation for Radiation Therapy: Current Developments, Clinical Considerations, and Future Directions.

Journal article Int J Radiat Oncol Biol Phys · May 1, 2024 Deep learning neural networks (DLNN) in Artificial intelligence (AI) have been extensively explored for automatic segmentation in radiotherapy (RT). In contrast to traditional model-based methods, data-driven AI-based models for auto-segmentation have show ... Full text Link to item Cite

Organ boundary delineation for automated diagnosis from multi-center using ultrasound images

Journal article Expert Systems with Applications · March 15, 2024 Delineation of prostate boundary is a critical procedure in multi-modal prostate registration and patient-specific anatomical modeling for surgical planning and image-guided biopsy of prostate cancer. Accurate segmentation of the prostate from medical tran ... Full text Cite

A reinforcement learning agent for head and neck intensity-modulated radiation therapy

Journal article Frontiers in Physics · January 1, 2024 Head and neck (HN) cancers pose a difficult problem in the planning of intensity-modulated radiation therapy (IMRT) treatment. The primary tumor can be large and asymmetrical, and multiple organs at risk (OARs) with varying dose-sparing goals lie close to ... Full text Cite

Radiation-induced acoustic signal denoising using a supervised deep learning framework for imaging and therapy monitoring.

Journal article Phys Med Biol · November 29, 2023 Radiation-induced acoustic (RA) imaging is a promising technique for visualizing the invisible radiation energy deposition in tissues, enabling new imaging modalities and real-time therapy monitoring. However, RA imaging signal often suffers from poor sign ... Full text Link to item Cite

Novel Solution for Using Neural Networks for Kidney Boundary Extraction in 2D Ultrasound Data.

Journal article Biomolecules · October 19, 2023 Background and Objective: Kidney ultrasound (US) imaging is a significant imaging modality for evaluating kidney health and is essential for diagnosis, treatment, surgical intervention planning, and follow-up assessments. Kidney US image segmentation consi ... Full text Link to item Cite

3Din vivodose verification in prostate proton therapy with deep learning-based proton-acoustic imaging.

Journal article Phys Med Biol · October 27, 2022 Dose delivery uncertainty is a major concern in proton therapy, adversely affecting the treatment precision and outcome. Recently, a promising technique, proton-acoustic (PA) imaging, has been developed to provide real-timein vivo3D dose verification. Howe ... Full text Link to item Cite

Input feature design and its impact on the performance of deep learning models for predicting fluence maps in intensity-modulated radiation therapy.

Journal article Phys Med Biol · October 21, 2022 Objective. Deep learning (DL) models for fluence map prediction (FMP) have great potential to reduce treatment planning time in intensity-modulated radiation therapy (IMRT) by avoiding the lengthy inverse optimization process. This study aims to improve th ... Full text Link to item Cite

H-ProSeg: Hybrid ultrasound prostate segmentation based on explainability-guided mathematical model.

Journal article Comput Methods Programs Biomed · June 2022 BACKGROUND AND OBJECTIVE: Accurate and robust prostate segmentation in transrectal ultrasound (TRUS) images is of great interest for image-guided prostate interventions and prostate cancer diagnosis. However, it remains a challenging task for various reaso ... Full text Link to item Cite

Technical note: Determining the applicability of a clinical knowledge-based learning model via prospective outlier detection.

Journal article Med Phys · April 2022 BACKGROUND: Knowledge-based planning (KBP) is increasingly implemented clinically because of its demonstrated ability to improve treatment planning efficiency and reduce plan quality variations. However, cases with large dose-volume histogram (DVH) predict ... Full text Link to item Cite

Purposeful irradiation of the epidural space to enhance local control without compromising cord sparing in spine radiosurgery†.

Journal article J Radiosurg SBRT · 2022 PURPOSE: The epidural space is a frequent site of cancer recurrence after spine stereotactic radiosurgery (SSRS). This may be due to microscopic disease in the epidural space which is underdosed to obey strict spinal cord dose constraints. We hypothesized ... Link to item Cite

A data-driven approach to optimal beam/arc angle selection for liver stereotactic body radiation therapy treatment planning.

Journal article Quant Imaging Med Surg · December 2021 BACKGROUND: Stereotactic body radiation therapy (SBRT) for liver cancer has shown promising therapeutic effects. Effective treatment relies not only on the precise delivery provided by image-guided radiation therapy (IGRT) but also high dose gradient forme ... Full text Link to item Cite

Artificial intelligence applications in intensity modulated radiation treatment planning: an overview.

Journal article Quant Imaging Med Surg · December 2021 Artificial intelligence (AI) refers to methods that improve and automate challenging human tasks by systematically capturing and applying relevant knowledge in these tasks. Over the past decades, a number of approaches have been developed to address differ ... Full text Link to item Cite

Assessing the robustness of artificial intelligence powered planning tools in radiotherapy clinical settings-a phantom simulation approach.

Journal article Quant Imaging Med Surg · December 2021 BACKGROUND: Artificial intelligence (AI) based radiotherapy treatment planning tools have gained interest in automating the treatment planning process. It is essential to understand their overall robustness in various clinical scenarios. This is an existin ... Full text Link to item Cite

Insights of an AI agent via analysis of prediction errors: a case study of fluence map prediction for radiation therapy planning.

Journal article Phys Med Biol · November 26, 2021 Purpose.We have previously reported an artificial intelligence (AI) agent that automatically generates intensity-modulated radiation therapy (IMRT) plans via fluence map prediction, by-passing inverse planning. This AI agent achieved clinically comparable ... Full text Link to item Cite

Introducing matrix sparsity with kernel truncation into dose calculations for fluence optimization.

Journal article Biomed Phys Eng Express · November 12, 2021 Deep learning algorithms for radiation therapy treatment planning automation require large patient datasets and complex architectures that often take hundreds of hours to train. Some of these algorithms require constant dose updating (such as with reinforc ... Full text Link to item Cite

An AI-Enabled Virtual Hands-On Teaching Tool for Treatment Planning: A Pancreas SBRT Pilot Study.

Journal article International journal of radiation oncology, biology, physics · November 2021 Purpose/objective(s)To develop a tutoring program to help physician and physics residents to learn pancreas stereotactic body radiation therapy (SBRT) treatment planning via carefully collected cases and a series of specially designed knowledge mo ... Full text Cite

An artificial intelligence-driven agent for real-time head-and-neck IMRT plan generation using conditional generative adversarial network (cGAN).

Journal article Med Phys · June 2021 PURPOSE: To develop an artificial intelligence (AI) agent for fully automated rapid head-and-neck intensity-modulated radiation therapy (IMRT) plan generation without time-consuming dose-volume-based inverse planning. METHODS: This AI agent was trained via ... Full text Link to item Cite

An Interpretable Planning Bot for Pancreas Stereotactic Body Radiation Therapy.

Journal article Int J Radiat Oncol Biol Phys · March 15, 2021 PURPOSE: Pancreas stereotactic body radiation therapy (SBRT) treatment planning requires planners to make sequential, time-consuming interactions with the treatment planning system to reach the optimal dose distribution. We sought to develop a reinforcemen ... Full text Link to item Cite

Radiation Therapy for Rectal Cancer: Executive Summary of an ASTRO Clinical Practice Guideline.

Journal article Pract Radiat Oncol · 2021 PURPOSE: This guideline reviews the evidence and provides recommendations for the indications and appropriate technique and dose of neoadjuvant radiation therapy (RT) in the treatment of localized rectal cancer. METHODS: The American Society for Radiation ... Full text Link to item Cite

Clinical Experience With Machine Learning-Based Automated Treatment Planning for Whole Breast Radiation Therapy.

Journal article Adv Radiat Oncol · 2021 PURPOSE: The machine learning-based automated treatment planning (MLAP) tool has been developed and evaluated for breast radiation therapy planning at our institution. We implemented MLAP for patient treatment and assessed our clinical experience for its p ... Full text Open Access Link to item Cite

Deep Learning-Based Fluence Map Prediction for Pancreas Stereotactic Body Radiation Therapy With Simultaneous Integrated Boost.

Journal article Adv Radiat Oncol · 2021 PURPOSE: Treatment planning for pancreas stereotactic body radiation therapy (SBRT) is a challenging task, especially with simultaneous integrated boost treatment approaches. We propose a deep learning (DL) framework to accurately predict fluence maps from ... Full text Link to item Cite

A Novel Machine Learning Model for Dose Prediction in Prostate Volumetric Modulated Arc Therapy Using Output Initialization and Optimization Priorities.

Journal article Front Artif Intell · 2021 Treatment planning for prostate volumetric modulated arc therapy (VMAT) can take 5-30 min per plan to optimize and calculate, limiting the number of plan options that can be explored before the final plan decision. Inspired by the speed and accuracy of mod ... Full text Link to item Cite

Technical note: Interpolated Pareto surface similarity metrics for multi-criteria optimization in radiation therapy.

Journal article Med Phys · December 2020 PURPOSE: There is a strong clinical need to evaluate different multi-criteria optimization (MCO) algorithms, including inverse optimization sampling algorithms and machine learning-based predictions. This study aims to develop and compare several interpola ... Full text Link to item Cite

Automatic IMRT planning via static field fluence prediction (AIP-SFFP): a deep learning algorithm for real-time prostate treatment planning.

Journal article Phys Med Biol · September 8, 2020 The purpose of this work was to develop a deep learning (DL) based algorithm, Automatic intensity-modulated radiotherapy (IMRT) Planning via Static Field Fluence Prediction (AIP-SFFP), for automated prostate IMRT planning with real-time planning efficiency ... Full text Link to item Cite

Knowledge-Based Tradeoff Hyperplanes for Head and Neck Treatment Planning.

Journal article Int J Radiat Oncol Biol Phys · April 1, 2020 PURPOSE: To develop a tradeoff hyperplane model to facilitate tradeoff decision-making before inverse planning. METHODS AND MATERIALS: We propose a model-based approach to determine the tradeoff hyperplanes that allow physicians to navigate the clinically ... Full text Link to item Cite

Knowledge Models as Teaching Aid for Training Intensity Modulated Radiation Therapy Planning: A Lung Cancer Case Study.

Journal article Front Artif Intell · 2020 Purpose: Artificial intelligence (AI) employs knowledge models that often behave as a black-box to the majority of users and are not designed to improve the skill level of users. In this study, we aim to demonstrate the feasibility that AI can serve as an ... Full text Link to item Cite

Fluence Map Prediction Using Deep Learning Models - Direct Plan Generation for Pancreas Stereotactic Body Radiation Therapy.

Journal article Front Artif Intell · 2020 Purpose: Treatment planning for pancreas stereotactic body radiation therapy (SBRT) is a difficult and time-consuming task. In this study, we aim to develop a novel deep learning framework to generate clinical-quality plans by direct prediction of fluence ... Full text Open Access Link to item Cite

Modeling of multiple planning target volumes for head and neck treatments in knowledge-based treatment planning.

Journal article Med Phys · September 2019 PURPOSE: The purpose of this study is to develop an accurate and reliable dose volume histogram (DVH) prediction method for external beam radiation therapy plans with multiple planning target volumes (PTVs). MATERIALS AND METHODS: We present a novel DVH pr ... Full text Link to item Cite

Three IMRT advanced planning tools: A multi-institutional side-by-side comparison.

Journal article J Appl Clin Med Phys · August 2019 PURPOSE: To assess three advanced radiation therapy treatment planning tools on the intensity-modulated radiation therapy (IMRT) quality and consistency when compared to the clinically approved plans, referred as manual plans, which were planned without us ... Full text Link to item Cite

Knowledge-based planning for intensity-modulated radiation therapy: A review of data-driven approaches.

Journal article Med Phys · June 2019 PURPOSE: Intensity-Modulated Radiation Therapy (IMRT), including its variations (including IMRT, Volumetric Arc Therapy (VMAT), and Tomotherapy), is a widely used and critically important technology for cancer treatment. It is a knowledge-intensive technol ... Full text Link to item Cite

Knowledge-Based Statistical Inference Method for Plan Quality Quantification.

Journal article Technol Cancer Res Treat · January 1, 2019 AIM: The aim of the study is to develop a geometrically adaptive and statistically robust plan quality inference method. METHODS AND MATERIALS: We propose a knowledge-based plan quality inference method that references to similar plans in the historical da ... Full text Open Access Link to item Cite

Goal-Driven Beam Setting Optimization for Whole-Breast Radiation Therapy.

Journal article Technol Cancer Res Treat · January 1, 2019 PURPOSE: To develop an automated optimization program to generate optimal beam settings for whole-breast radiation therapy driven by clinically oriented goals. MATERIALS AND METHODS: Forty patients were retrospectively included in this study. Each patient' ... Full text Open Access Link to item Cite

Automatic Planning of Whole Breast Radiation Therapy Using Machine Learning Models.

Journal article Front Oncol · 2019 Purpose: To develop an automatic treatment planning system for whole breast radiation therapy (WBRT) based on two intensity-modulated tangential fields, enabling near-real-time planning. Methods and Materials: A total of 40 WBRT plans from a single institu ... Full text Open Access Link to item Cite

Incorporating Case-Based Reasoning for Radiation Therapy Knowledge Modeling: A Pelvic Case Study.

Journal article Technol Cancer Res Treat · January 1, 2019 Knowledge models in radiotherapy capture the relation between patient anatomy and dosimetry to provide treatment planning guidance. When treatment schemes evolve, existing models struggle to predict accurately. We propose a case-based reasoning framework d ... Full text Open Access Link to item Cite

Temporal lobe injury patterns following intensity modulated radiotherapy in a large cohort of nasopharyngeal carcinoma patients.

Journal article Oral Oncol · October 2018 OBJECTIVES: To analyze the correlation between dose-volume-histograms (DVHs) with three patterns (edema, enhancement, and necrosis) of temporal lobe injury (TLI) in patients receiving intensity modulated radiation therapy (IMRT) for nasopharyngeal carcinom ... Full text Link to item Cite

Machine learning and modeling: Data, validation, communication challenges.

Journal article Med Phys · October 2018 With the era of big data, the utilization of machine learning algorithms in radiation oncology is rapidly growing with applications including: treatment response modeling, treatment planning, contouring, organ segmentation, image-guidance, motion tracking, ... Full text Link to item Cite

Lung IMRT planning with automatic determination of beam angle configurations.

Journal article Phys Med Biol · July 6, 2018 Beam angle configuration is a major planning decision in intensity modulated radiation treatment (IMRT) that has a significant impact on dose distributions and thus quality of treatment, especially in complex planning cases such as those for lung cancer tr ... Full text Link to item Cite

Improving Quality and Consistency in NRG Oncology Radiation Therapy Oncology Group 0631 for Spine Radiosurgery via Knowledge-Based Planning.

Journal article Int J Radiat Oncol Biol Phys · March 15, 2018 PURPOSE: To use knowledge-based planning (KBP) as a method of producing high-quality, consistent, protocol-compliant treatment plans in a complex setting of spine stereotactic body radiation therapy on NRG Oncology Radiation Therapy Oncology Group (RTOG) 0 ... Full text Link to item Cite

American Association of Physicists in Medicine Task Group 263: Standardizing Nomenclatures in Radiation Oncology.

Journal article Int J Radiat Oncol Biol Phys · March 15, 2018 A substantial barrier to the single- and multi-institutional aggregation of data to supporting clinical trials, practice quality improvement efforts, and development of big data analytics resource systems is the lack of standardized nomenclatures for expre ... Full text Open Access Link to item Cite

An Ensemble Approach to Knowledge-Based Intensity-Modulated Radiation Therapy Planning.

Journal article Front Oncol · 2018 Knowledge-based planning (KBP) utilizes experienced planners' knowledge embedded in prior plans to estimate optimal achievable dose volume histogram (DVH) of new cases. In the regression-based KBP framework, previously planned patients' anatomical features ... Full text Open Access Link to item Cite

Outlier identification in radiation therapy knowledge-based planning: A study of pelvic cases.

Journal article Med Phys · November 2017 PURPOSE: The purpose of this study was to apply statistical metrics to identify outliers and to investigate the impact of outliers on knowledge-based planning in radiation therapy of pelvic cases. We also aimed to develop a systematic workflow for identify ... Full text Link to item Cite

Exploring the Margin Recipe for Online Adaptive Radiation Therapy for Intermediate-Risk Prostate Cancer: An Intrafractional Seminal Vesicles Motion Analysis.

Journal article Int J Radiat Oncol Biol Phys · June 1, 2017 PURPOSE: To provide a benchmark for seminal vesicle (SV) margin selection to account for intrafractional motion and to investigate the effectiveness of 2 motion surrogates in predicting intrafractional SV coverage. METHODS AND MATERIALS: Fifteen prostate p ... Full text Link to item Cite

Diode-based transmission detector for IMRT delivery monitoring: a validation study.

Journal article J Appl Clin Med Phys · September 8, 2016 The purpose of this work was to evaluate the potential of a new transmission detector for real-time quality assurance of dynamic-MLC-based radiotherapy. The accuracy of detecting dose variation and static/dynamic MLC position deviations was measured, as we ... Full text Open Access Link to item Cite

Diode-based transmission detector for IMRT delivery monitoring: a validation study.

Journal article J Appl Clin Med Phys · September 2016 The purpose of this work was to evaluate the potential of a new transmission detector for real-time quality assurance of dynamic-MLC-based radiotherapy. The accuracy of detecting dose variation and static/dynamic MLC position deviations was measured, as we ... Full text Link to item Cite

SU-F-T-98: Knowledge Modeling for The Outcome of Brain Stereotactic Radiosurgery.

Journal article Med Phys · June 2016 PURPOSE: To create a model that will better predict the survival time for patients that were treated with stereotactic radiosurgery for brain metastases using a support vector machine regression model. METHODS: This study utilized data from 481 patients, w ... Full text Link to item Cite

SU-F-T-97: Outlier Identification in Radiation Therapy Knowledge Modeling.

Journal article Med Phys · June 2016 PURPOSE: To investigate the impact of outliers on knowledge modeling in radiation therapy, and develop a systematic workflow for identifying and analyzing geometric and dosimetric outliers using pelvic cases. METHODS: Four groups (G1-G4) of pelvic plans we ... Full text Link to item Cite

MO-D-BRC-03: Knowledge-Based Planning.

Journal article Med Phys · June 2016 Treatment planning is a central part of radiation therapy, including delineation in tumor volumes and critical organs, setting treatment goals of prescription doses to the tumor targets and tolerance doses to the critical organs, and finally generation of ... Full text Link to item Cite

SU-F-T-352: Development of a Knowledge Based Automatic Lung IMRT Planning Algorithm with Non-Coplanar Beams.

Journal article Med Phys · June 2016 PURPOSE: To improve the robustness of a knowledge based automatic lung IMRT planning method and to further validate the reliability of this algorithm by utilizing for the planning of clinical cases with non-coplanar beams. METHODS: A lung IMRT planning met ... Full text Link to item Cite

WE-AB-209-05: Development of an Ultra-Fast High Quality Whole Breast Radiotherapy Treatment Planning System.

Journal article Med Phys · June 2016 PURPOSE: To enable near-real-time (<20sec) and interactive planning without compromising quality for whole breast RT treatment planning using tangential fields. METHODS: Whole breast RT plans from 20 patients treated with single energy (SE, 6MV, 10 patient ... Full text Link to item Cite

Establishing the feasibility of the dosimetric compliance criteria of RTOG 1308: phase III randomized trial comparing overall survival after photon versus proton radiochemotherapy for inoperable stage II-IIIB NSCLC.

Journal article Radiat Oncol · May 4, 2016 BACKGROUND: To establish the feasibility of the dosimetric compliance criteria of the RTOG 1308 trial through testing against Intensity Modulation Radiation Therapy (IMRT) and Passive Scattering Proton Therapy (PSPT) plans. METHODS: Twenty-six lung IMRT an ... Full text Link to item Cite

Atlas-guided prostate intensity modulated radiation therapy (IMRT) planning.

Journal article Phys Med Biol · September 21, 2015 An atlas-based IMRT planning technique for prostate cancer was developed and evaluated. A multi-dose atlas was built based on the anatomy patterns of the patients, more specifically, the percent distance to the prostate and the concaveness angle formed by ... Full text Link to item Cite

Utilizing knowledge from prior plans in the evaluation of quality assurance.

Journal article Phys Med Biol · June 21, 2015 Increased interest regarding sensitivity of pre-treatment intensity modulated radiotherapy and volumetric modulated arc radiotherapy (VMAT) quality assurance (QA) to delivery errors has led to the development of dose-volume histogram (DVH) based analysis. ... Full text Link to item Cite

TU-AB-303-06: Does Online Adaptive Radiation Therapy Mean Zero Margin for Intermediate-Risk Prostate Cancer? An Intra-Fractional Seminal Vesicles Motion Analysis.

Journal article Med Phys · June 2015 PURPOSE: To provide benchmark for seminal vesicles (SVs) margin selection to account for intra-fractional motion; and to investigate the effectiveness of two motion surrogates in predicting intra-fractional SV underdosage. METHODS: 9 prostate SBRT patients ... Full text Link to item Cite

SU-E-T-434: Fixed Margin Or Online Adaptation for Intermediate-Risk Prostate Stereotactic Body Radiation Therapy? A Dosimetric Study.

Journal article Med Phys · June 2015 PURPOSE: To investigate the choice of fixed margin or online adaptation when treating intermediate-risk prostate cancer including seminal vesicles (SV) using stereotactic body radiation therapy (SBRT). METHODS: 9 prostate SBRT patients were retrospectively ... Full text Link to item Cite

SU-E-P-22: AAPM Task Group 263 Tackling Standardization of Nomenclature for Radiation Therapy.

Journal article Med Phys · June 2015 PURPOSE: There is growing recognition of need for increased clarity and consistency in the nomenclatures used for body and organ structures, DVH metrics, toxicity, dose and volume units, etc. Standardization has multiple benefits; e.g. facilitating data co ... Full text Link to item Cite

WE-E-BRB-02: Knowledge Modeling For Clinical Treatment Planning.

Journal article Med Phys · June 2015 UNLABELLED: The knowledge-based treatment planning automation has evolved from academic research from the clinical application with the involvement of the major industry TPS vendors. Previous work proved the concept that IMRT or VMAT plans can be designed ... Full text Link to item Cite

SU-F-BRD-03: Evaluation of Head-Neck IMPT Plans Quality Using a Knowledge Based Model.

Journal article Med Phys · June 2015 PURPOSE: To develop and evaluate a model that predicts the dose volume histogram (DVH) of head and neck IMPT plans based on knowledge of prior plans. METHODS: Total of forty Head-Neck cancer patients underwent IMPT were used in the study. Using thirty pati ... Full text Link to item Cite

Quantitative comparison of automatic and manual IMRT optimization for prostate cancer: the benefits of DVH prediction.

Journal article J Appl Clin Med Phys · March 8, 2015 A recent publication indicated that the patient anatomical feature (PAF) model was capable of predicting optimal objectives based on past experience. In this study, the benefits of IMRT optimization using PAF-predicted objectives as guidance for prostate w ... Full text Open Access Link to item Cite

Standardized beam bouquets for lung IMRT planning.

Journal article Phys Med Biol · March 7, 2015 The selection of the incident angles of the treatment beams is a critical component of intensity modulated radiation therapy (IMRT) planning for lung cancer due to significant variations in tumor location, tumor size and patient anatomy. We investigate the ... Full text Link to item Cite

From active shape model to active optical flow model: a shape-based approach to predicting voxel-level dose distributions in spine SBRT.

Journal article Phys Med Biol · March 7, 2015 Prediction of achievable dose distribution in spine stereotactic body radiation therapy (SBRT) can help in designing high-quality treatment plans to maximally protect spinal cords and to effectively control tumours. Dose distributions at spinal cords are p ... Full text Link to item Cite

Impact of dose calculation accuracy during optimization on lung IMRT plan quality.

Journal article J Appl Clin Med Phys · January 8, 2015 The purpose of this study was to evaluate the effect of dose calculation accuracy and the use of an intermediate dose calculation step during the optimization of intensity-modulated radiation therapy (IMRT) planning on the final plan quality for lung cance ... Full text Link to item Cite

Quality assurance for online adapted treatment plans: benchmarking and delivery monitoring simulation.

Journal article Med Phys · January 2015 PURPOSE: An important challenge facing online adaptive radiation therapy is the development of feasible and efficient quality assurance (QA). This project aimed to validate the deliverability of online adapted plans and develop a proof-of-concept online de ... Full text Link to item Cite

An active optical flow model for dose prediction in spinal sbrt plans

Journal article Lecture Notes in Computational Vision and Biomechanics · January 1, 2015 Accurate dose predication is critical to spinal stereotactic body radiation therapy (SBRT). It enables radiation oncologists and planners to design treatment plans that maximally protect spinal cord while effectively controlling surrounding tumors. Spinal ... Full text Cite

Quantitative comparison of automatic and manual IMRT optimization for prostate cancer: The benefits of DVH prediction

Journal article Journal of Applied Clinical Medical Physics · January 1, 2015 A recent publication indicated that the patient anatomical feature (PAF) model was capable of predicting optimal objectives based on past experience. In this study, the benefits of IMRT optimization using PAF-predicted objectives as guidance for prostate w ... Full text Cite

SU-E-J-80: Interplay Effect Between VMAT Intensity Modulation and Tumor Motion in Hypofractioned Lung Treatment, Investigated with 3D Pressage Dosimeter.

Journal article Med Phys · June 2014 PURPOSE: To demonstrate an embedded tissue equivalent presage dosimeter for measuring 3D doses in moving tumors and to study the interplay effect between the tumor motion and intensity modulation in hypofractioned Volumetric Modulated Arc Therapy(VMAT) lun ... Full text Link to item Cite

TH-A-9A-10: Prostate SBRT Delivery with Flattening-Filter-Free Mode: Benefit and Accuracy.

Journal article Med Phys · June 2014 PURPOSE: Flattening-filter-free (FFF) beam mode offered on TrueBeam™ linac enables delivering IMRT at 2400 MU/min dose rate. This study investigates the benefit and delivery accuracy of using high dose rate in the context of prostate SBRT. METHODS: 8 prost ... Full text Link to item Cite

WE-A-BRD-01: Innovation in Radiation Therapy Planning I: Knowledge Guided Treatment Planning.

Journal article Med Phys · June 2014 Intensity modulated radiation therapy (IMRT) and Volumetric Modulated Arc Therapy (VMAT) offer the capability of normal tissues and organs sparing. However, the exact amount of sparing is often unknown until the plan is complete. This lack of prior guidanc ... Full text Link to item Cite

SU-E-J-177: Understanding the Seminal Vesicle's Motion Relative to the Prostate: Range and Pattern.

Journal article Med Phys · June 2014 PURPOSE: To investigate inter-fractional (inter-fx) and intra-fractional (intra-fx) seminal vesicle (SV) motion to determine motion management strategies for prostate SBRT. METHODS: 9 prostate SBRT patients (37Gy/5fx) were studied. All patients were implan ... Full text Link to item Cite

MO-C-17A-07: Building Atlas for Automatic Prostate IMRT Planning: Anatomical Feature Parameterization and Classification.

Journal article Med Phys · June 2014 PURPOSE: To establish and evaluate a prostate IMRT plan atlas to provide accurate dose guidance for dose-guided automatic planning (DAP) technique. METHODS: 25 prostate cancer patients treated with IMRT were studied. The anatomy of prostate cancer cases wa ... Full text Link to item Cite

SU-E-T-527: Prior Knowledge Guided TomoTherapy Treatment Planning.

Journal article Med Phys · June 2014 PURPOSE: The quality and efficiency of radiotherapy treatment planning are highly planer dependent. Previously we have developed a statistical model to correlate anatomical features with dosimetry features of head and neck Tomotherapy treatment. The model ... Full text Link to item Cite

TH-E-BRF-10: Interim Esophageal Cancer Response Assessment Via 18FDG-PET Scanning During Radiation Therapy.

Journal article Med Phys · June 2014 PURPOSE: Local failure occurs in a large proportion of esophageal cancer patients treated with chemoradiation. The treatment strategy for non-responders could potentially be modified if they are identified during therapy. This work investigates the utility ... Full text Link to item Cite

TU-C-BRE-07: Quantifying the Clinical Impact of VMAT Delivery Errors Relative to Prior Patients' Plans and Adjusted for Anatomical Differences.

Journal article Med Phys · June 2014 PURPOSE: There is increased interest in the Radiation Oncology Physics community regarding sensitivity of pre-treatment IMRT/VMAT QA to delivery errors. Consequently, tools mapping pre-treatment QA to the patient DVH have been developed. However, the quant ... Full text Link to item Cite

WE-G-9A-01: Radiation Oncology Outcomes Informatics.

Journal article Med Phys · June 2014 The construction of databases and support software to enable routine and systematic aggregation, analysis and reporting of patient outcomes data is emerging as an important area. "How have results for our patients been affected by the improvements we have ... Full text Link to item Cite

TU-C-17A-11: Progressive Knowledge Modeling for Pelvic IMRT/VMAT Treatment Planning.

Journal article Med Phys · June 2014 PURPOSE: To investigate the feasibility of progressive knowledge modeling for IMRT/VMAT treatment planning for multiple cancer types in the pelvic region. METHODS: The treatment planning knowledge model quantifies correlations between patient anatomical fe ... Full text Link to item Cite

SU-E-T-229: Machine Learning Methods for Knowledge Based Treatment Planning of Prostate Cancer.

Journal article Med Phys · June 2014 PURPOSE: To evaluate the accuracy of the dose prediction models constructed with machine learning techniques, Support Vector Machine (SVM) and Artificial Neural Network (ANN) for the prediction of dose volume histogram (DVH) of organs-at-risk (OAR) in IMRT ... Full text Link to item Cite

Incorporating single-side sparing in models for predicting parotid dose sparing in head and neck IMRT.

Journal article Med Phys · February 2014 PURPOSE: Sparing of single-side parotid gland is a common practice in head-and-neck (HN) intensity modulated radiation therapy (IMRT) planning. It is a special case of dose sparing tradeoff between different organs-at-risk. The authors describe an improved ... Full text Link to item Cite

Dosimetric comparison of 3D conformal, IMRT, and V-MAT techniques for accelerated partial-breast irradiation (APBI).

Journal article Med Dosim · 2014 The purpose is to dosimetrically compare the following 3 delivery techniques: 3-dimensional conformal radiation therapy (3D-CRT), intensity-modulated arc therapy (IMRT), and volumetric-modulated arc therapy (V-MAT) in the treatment of accelerated partial-b ... Full text Link to item Cite

Modeling the dosimetry of organ-at-risk in head and neck IMRT planning: an intertechnique and interinstitutional study.

Journal article Med Phys · December 2013 PURPOSE: To build a statistical model to quantitatively correlate the anatomic features of structures and the corresponding dose-volume histogram (DVH) of head and neck (HN) Tomotherapy (Tomo) plans. To study if the model built upon one intensity modulated ... Full text Link to item Cite

Strategies for automatic online treatment plan reoptimization using clinical treatment planning system: a planning parameters study.

Journal article Med Phys · November 2013 PURPOSE: Adaptive radiation therapy for prostate cancer using online reoptimization provides an improved control of interfractional anatomy variations. However, the clinical implementation of online reoptimization is currently limited by the low efficiency ... Full text Link to item Cite

Single institution's dosimetry and IGRT analysis of prostate SBRT.

Journal article Radiat Oncol · September 13, 2013 BACKGROUND AND PURPOSE: To report single institution's IGRT and dosimetry analysis on the 37 Gy/5 fraction prostate SBRT clinical trial. MATERIALS/METHODS: The IRB (Duke University Medical Center) approved clinical trial has treated 28 patients with stage ... Full text Link to item Cite

A knowledge-based approach to improving and homogenizing intensity modulated radiation therapy planning quality among treatment centers: an example application to prostate cancer planning.

Journal article Int J Radiat Oncol Biol Phys · September 1, 2013 PURPOSE: Intensity modulated radiation therapy (IMRT) treatment planning can have wide variation among different treatment centers. We propose a system to leverage the IMRT planning experience of larger institutions to automatically create high-quality pla ... Full text Link to item Cite

SU-E-T-143: Dosimetric Characteristics of TrueBeam STx System with High Definition Multi-Leaf Collimator: Commissioning of Stereotactic Radiosurgery.

Journal article Med Phys · June 2013 IntroductionDosimetric characteristics of one TrueBeam STx treatment unit with a 120-leaf high definition multileaf collimator (HD120MLC) are systematically measured for commissioning of stereotactic radiosurgery (SRS). Due to limited data available, it is ... Full text Link to item Cite

TH-C-500-01: Collaborative Knowledge Modeling and Integration for Radiation Therapy Planning.

Journal article Med Phys · June 2013 Experience, knowledge, and guidelines about intensity modulated radiation therapy (IMRT) have been accumulated over the past decade, but they have largely not been formally extracted or modeled to support more efficient and optimal treatment planning. Ther ... Full text Link to item Cite

TH-C-137-11: Dose-Guided Automatic IMRT Planning: A Feasibility Study.

Journal article Med Phys · June 2013 PURPOSE: To develop and evaluate an automatic planning technique for prostate cancer utilizing prior expert plan's dose as guidance. METHODS: A plan atlas was created using 10 expert prostate IMRT plans covering a variety of typical anatomical configuratio ... Full text Link to item Cite

Quantitative analysis of the factors which affect the interpatient organ-at-risk dose sparing variation in IMRT plans.

Journal article Med Phys · November 2012 Featured Publication PURPOSE: The authors present an evidence-based approach to quantify the effects of an array of patient anatomical features of the planning target volumes (PTVs) and organs-at-risk (OARs) and their spatial relationships on the interpatient OAR dose sparing ... Full text Link to item Cite

SU-E-T-104: Commissioning and Dosimetric Characteristics of TrueBeam System: Composite Data of Three TrueBeam Machines.

Journal article Med Phys · June 2012 INTRODUCTION: A TrueBeam linear accelerator (TB-LINAC) is designed to deliver standard flattened and flattening-filter-free (FFF) beams. In our institute, three TB-LINAC units are installed. In this work, composite data of the three units and multi-unit co ... Full text Link to item Cite

SU-E-J-23: Prostate Bed Motion Study Using Surgical Clips Based on Daily CBCT.

Journal article Med Phys · June 2012 PURPOSE: To study prostate-bed motion after prostatectomy using the surgical clips as a surrogate. METHODS: On the treatment planning CT, surgical clips within the PTV are identified and contoured. They are also identified and contoured in each daily CBCT. ... Full text Link to item Cite

SU-E-J-16: Prostate Bed Motion during Post-Prostatectomy Radiotherapy.

Journal article Med Phys · June 2012 PURPOSE: To report the inter-fractional prostate bed motion (PBM) during post-prostatectomy radiotherapy using cone-beam CT (CBCT). The correlations between PBM, anterior rectal wall and posterior bladder wall shifts were also investigated. METHODS: Sevent ... Full text Link to item Cite

MO-D-BRB-09: Treatment Delivery QA for Online Adaptive Radiation Therapy Based on Dynamic Machine Information (DMI): A Feasibility Study.

Journal article Med Phys · June 2012 PURPOSE: To implement a quality assurance (QA) system for the treatment delivery of online adaptive radiation therapy utilizing Dynamic Machine Information (DMI). MATERIALS AND METHODS: DMI provides the expected/actual MLC leaf-positions, delivered MU, and ... Full text Link to item Cite

SU-E-T-559: Evaluation of Flatening Filter Free (FFF) Beams in Radiotherapy of Head and Neck Cancer.

Journal article Med Phys · June 2012 PURPOSE: To investigate th applicability of the flattening filter free (FFF) to fractionated radiotherapy of head and neck cancer. METHODS: Twelve patients previously treated with IMRT were selected. A SIB protocol was chosen so that 66/54 Gy were prescrib ... Full text Link to item Cite

Volumetric-modulated arc therapy: effective and efficient end-to-end patient-specific quality assurance.

Journal article Int J Radiat Oncol Biol Phys · April 1, 2012 Featured Publication PURPOSE: To explore an effective and efficient end-to-end patient-specific quality-assurance (QA) protocol for volumetric modulated arc radiotherapy (VMAT) and to evaluate the suitability of a stationary radiotherapy QA device (two-dimensional [2D] ion cha ... Full text Link to item Cite

Development and clinical evaluation of a three-dimensional cone-beam computed tomography estimation method using a deformation field map.

Journal article Int J Radiat Oncol Biol Phys · April 1, 2012 PURPOSE: To develop a three-dimensional (3D) cone-beam computed tomography (CBCT) estimation method using a deformation field map, and to evaluate and optimize the efficiency and accuracy of the method for use in the clinical setting. METHODS AND MATERIALS ... Full text Link to item Cite

IMRT treatment of anal cancer with a scrotal shield.

Journal article Med Dosim · 2012 The risk of sterility in males undergoing radiotherapy in the pelvic region indicates the use of a shielding device, which offers protection to the testes for patients wishing to maintain fertility. The use of such devices in the realm of intensity-modulat ... Full text Link to item Cite

Development of a 4D dosimetry simulation system in radiotherapy

Journal article International Journal of Biomedical Engineering and Technology · January 1, 2012 Featured Publication 4D CT image sets are used to encode patient-organ motion and to calculate the dose delivered during each respiratory phase. The dose-per-phase is summarised to the total dose via deformable registration. The system incorporates the actual beam parameters a ... Full text Cite

Adaptive prostate IGRT combining online re-optimization and re-positioning: a feasibility study.

Journal article Phys Med Biol · March 7, 2011 Featured Publication In prostate radiation therapy, inter-fractional organ motion/deformation has posed significant challenges on reliable daily dose delivery. To correct for this issue, off-line re-optimization and online re-positioning have been used clinically. In this pape ... Full text Link to item Cite

A planning quality evaluation tool for prostate adaptive IMRT based on machine learning.

Journal article Med Phys · February 2011 Featured Publication PURPOSE: To ensure plan quality for adaptive IMRT of the prostate, we developed a quantitative evaluation tool using a machine learning approach. This tool generates dose volume histograms (DVHs) of organs-at-risk (OARs) based on prior plans as a reference ... Full text Link to item Cite

An image-guided technique for planning and verification of supine craniospinal irradiation.

Journal article J Appl Clin Med Phys · January 31, 2011 Featured Publication We present a technique for planning and verification of craniospinal treatment with the patient in the supine position. Treatment delivery and verification is streamlined through the use of modern imaging techniques. Treatments use two lateral brain fields ... Full text Link to item Cite

Adaptive radiation therapy: technical components and clinical applications.

Journal article Cancer J · 2011 In current standard radiation therapy process, patient anatomy is represented by the snapshot of computed tomographic images at the simulation for treatment planning. However, patient anatomy during the treatment course is not static, and the changes can b ... Full text Link to item Cite

Digital tomosynthesis for respiratory gated liver treatment: clinical feasibility for daily image guidance.

Journal article Int J Radiat Oncol Biol Phys · January 1, 2011 PURPOSE: Breath-hold (BH) treatment minimizes internal target volumes (ITV) when treating sites prone to motion. Digital tomosynthesis (DTS) imaging has advantages over cone-beam CT (CBCT) for BH imaging: BH-DTS scan can be completed during a single breath ... Full text Link to item Cite

An image-guided technique for planning and verification of supine craniospinal irradiation

Journal article Journal of Applied Clinical Medical Physics · January 1, 2011 We present a technique for planning and verification of craniospinal treatment with the patient in the supine position. Treatment delivery and verification is streamlined through the use of modern imaging techniques. Treatments use two lateral brain fields ... Full text Cite

Intensity-modulated radiation therapy for anal malignancies: a preliminary toxicity and disease outcomes analysis.

Journal article Int J Radiat Oncol Biol Phys · December 1, 2010 PURPOSE: Intensity-modulated radiation therapy (IMRT) has the potential to reduce toxicities associated with chemoradiotherapy in the treatment of anal cancer. This study reports the results of using IMRT in the treatment of anal cancer. METHODS AND MATERI ... Full text Link to item Cite

Impact of volumetric modulated arc therapy technique on treatment with partial breast irradiation.

Journal article Int J Radiat Oncol Biol Phys · September 1, 2010 PURPOSE: To investigate the technical feasibility of volumetric modulated arc therapy (V-MAT) in the delivery of partial breast irradiation (PBI). METHODS AND MATERIALS: V-MAT and the standard, three-dimensional conformal radiotherapy (3D-CRT), were compar ... Full text Link to item Cite

Arc-modulated radiation therapy based on linear models.

Journal article Phys Med Biol · July 7, 2010 Featured Publication This paper reports an inverse arc-modulated radiation therapy planning technique based on linear models. It is implemented with a two-step procedure. First, fluence maps for 36 fixed-gantry beams are generated using a linear model-based intensity-modulated ... Full text Link to item Cite

Radiotherapy treatment plans with RapidArc for prostate cancer involving seminal vesicles and lymph nodes.

Journal article Int J Radiat Oncol Biol Phys · March 1, 2010 PURPOSE: Dosimetric results and treatment delivery efficiency of RapidArc plans to those of conventional intensity-modulated radiotherapy (IMRT) plans were compared using the Eclipse treatment planning system for high-risk prostate cancer. MATERIALS AND ME ... Full text Link to item Cite

Similarities between static and rotational intensity-modulated plans.

Journal article Phys Med Biol · January 7, 2010 Featured Publication The aim of this study was to explore similarities between intensity-modulated radiotherapy (IMRT) and intensity-modulated arc therapy (IMAT) techniques in the context of the number of multi-leaf collimator (MLC) segments required to achieve plan objectives ... Full text Link to item Cite

On-line adaptive radiation therapy: feasibility and clinical study.

Journal article J Oncol · 2010 The purpose of this paper is to evaluate the feasibility and clinical dosimetric benefit of an on-line, that is, with the patient in the treatment position, Adaptive Radiation Therapy (ART) system for prostate cancer treatment based on daily cone-beam CT i ... Full text Open Access Link to item Cite

Patient specific quality assurance: Transition from IMRT to IMAT

Journal article Journal of Physics Conference Series · January 1, 2010 The purpose of this study was to test a patient-specific quality assurance (QA) protocol for intensity-modulated arc radiotherapy (IMAT), and to evaluate the use of an intensity-modulated stationary radiotherapy QA device (2D ion chamber array). Thirty-nin ... Full text Cite

ExacTrac X-ray 6 degree-of-freedom image-guidance for intracranial non-invasive stereotactic radiotherapy: comparison with kilo-voltage cone-beam CT.

Journal article Radiother Oncol · December 2009 BACKGROUND AND PURPOSE: To compare the residual setup errors measured with ExacTrac X-ray 6 degree-of-freedom (6D) and cone-beam computed tomography (CBCT) for a head phantom and patients receiving intracranial non-invasive fractionated stereotactic radiot ... Full text Link to item Cite

Volumetric arc intensity-modulated therapy for spine body radiotherapy: comparison with static intensity-modulated treatment.

Journal article Int J Radiat Oncol Biol Phys · December 1, 2009 Featured Publication PURPOSE: This clinical study evaluates the feasibility of using volumetric arc-modulated treatment (VMAT) for spine stereotactic body radiotherapy (SBRT) to achieve highly conformal dose distributions that spare adjacent organs at risk (OAR) with reduced t ... Full text Link to item Cite

Tradeoffs of integrating real-time tracking into IGRT for prostate cancer treatment.

Journal article Phys Med Biol · September 7, 2009 This study investigated the integration of the Calypso real-time tracking system, based on implanted ferromagnetic transponders and a detector array, into the current process for image-guided radiation treatment (IGRT) of prostate cancer at our institution ... Full text Link to item Cite

Comparison of online IGRT techniques for prostate IMRT treatment: adaptive vs repositioning correction.

Journal article Med Phys · May 2009 This study compares three online image guidance techniques (IGRT) for prostate IMRT treatment: bony-anatomy matching, soft-tissue matching, and online replanning. Six prostate IMRT patients were studied. Five daily CBCT scans from the first week were acqui ... Full text Link to item Cite

Ice as a water-equivalent solid medium for brachytherapy dosimetric measurements.

Journal article Radiat Environ Biophys · April 2009 Precise positioning of source and dosimeters is essential in the experimental determination of dosimetric characteristics of brachytherapy sources. Various near-water equivalent solid phantoms have been used to achieve the necessary precision in the positi ... Full text Link to item Cite

Stereotactic body radiotherapy for lesions of the spine and paraspinal regions.

Journal article Int J Radiat Oncol Biol Phys · April 1, 2009 PURPOSE: To describe our experience and clinical strategy for stereotactic body radiotherapy (SBRT) of spinal lesions. METHODS AND MATERIALS: Thirty-two patients with 33 spinal lesions underwent computed tomography-based simulation while free breathing. Gr ... Full text Link to item Cite

Comparing digital tomosynthesis to cone-beam CT for position verification in patients undergoing partial breast irradiation.

Journal article Int J Radiat Oncol Biol Phys · March 1, 2009 PURPOSE: To evaluate digital tomosynthesis (DTS) technology for daily positioning of patients receiving accelerated partial breast irradiation (APBI) and to compare the positioning accuracy of DTS to three-dimensional cone-beam computed tomography (CBCT). ... Full text Link to item Cite

Refinement of treatment setup and target localization accuracy using three-dimensional cone-beam computed tomography for stereotactic body radiotherapy.

Journal article Int J Radiat Oncol Biol Phys · February 1, 2009 PURPOSES: To quantitatively compare two-dimensional (2D) orthogonal kV with three-dimensional (3D) cone-beam CT (CBCT) for target localization; and to assess intrafraction motion with kV images in patients undergoing stereotactic body radiotherapy (SBRT). ... Full text Link to item Cite

Impact of collimator leaf width and treatment technique on stereotactic radiosurgery and radiotherapy plans for intra- and extracranial lesions.

Journal article Radiat Oncol · January 21, 2009 BACKGROUND: This study evaluated the dosimetric impact of various treatment techniques as well as collimator leaf width (2.5 vs 5 mm) for three groups of tumors -- spine tumors, brain tumors abutting the brainstem, and liver tumors. These lesions often pre ... Full text Open Access Link to item Cite

Impact of collimator leaf width and treatment technique on stereotactic radiosurgery and radiotherapy plans for intra- and extracranial lesions

Journal article Radiation Oncology · January 21, 2009 Background: This study evaluated the dosimetric impact of various treatment techniques as well as collimator leaf width (2.5 vs 5 mm) for three groups of tumors - spine tumors, brain tumors abutting the brainstem, and liver tumors. These lesions often pres ... Full text Cite

Clinical evaluation of positioning verification using digital tomosynthesis and bony anatomy and soft tissues for prostate image-guided radiotherapy.

Journal article Int J Radiat Oncol Biol Phys · January 1, 2009 PURPOSE: To evaluate on-board digital tomosynthesis (DTS) for patient positioning vs. two-dimensional (2D) radiography and three-dimensional cone beam (CBCT). METHODS AND MATERIALS: A total of 92 image sessions from 9 prostate cancer patients were analyzed ... Full text Link to item Cite

Analysis of image quality for real-time target tracking using simultaneous kV-MV imaging.

Journal article Med Phys · December 2008 Real-time tracking can provide high accuracy localization for a moving target and minimize the effect of motion. Simultaneous kV-MV imaging has been proposed as a real-time tracking technique by utilizing the existing kV on-board imager (OBI) and the MV el ... Full text Link to item Cite

Dosimetric characteristics of novalis Tx system with high definition multileaf collimator.

Journal article Med Phys · October 2008 A new Novalis Tx system equipped with a high definition multileaf collimator (HDMLC) recently became available to perform both image-guided radiosurgery and conventional radiotherapy. It is capable of delivering a highly conformal radiation dose with three ... Full text Link to item Cite

A novel digital tomosynthesis (DTS) reconstruction method using a deformation field map.

Journal article Med Phys · July 2008 We developed a novel digital tomosynthesis (DTS) reconstruction method using a deformation field map to optimally estimate volumetric information in DTS images. The deformation field map is solved by using prior information, a deformation model, and new pr ... Full text Link to item Cite

Deformation estimation and analysis for adaptive radiation therapy

Journal article Progress in Biomedical Optics and Imaging Proceedings of SPIE · May 19, 2008 To accommodate the inter- and intra-fractional motion of internal organs in prostate cancer treatment, a large margin (5mm-25mm) has often to be considered during radiation therapy planning. Normally, the inter- fractional motion is more substantial than t ... Full text Cite

The impact of respiratory motion and treatment technique on stereotactic body radiation therapy for liver cancer.

Journal article Med Phys · April 2008 Featured Publication Stereotactic body radiation therapy (SBRT), which delivers a much higher fractional dose than conventional treatment in only a few fractions, is an effective treatment for liver metastases. For patients who are treated under free-breathing conditions, howe ... Full text Link to item Cite

Integration of cone-beam CT in stereotactic body radiation therapy.

Journal article Technol Cancer Res Treat · April 2008 This report describes the technique and initial experience using cone beam CT (CBCT) for localization of treatment targets in patients undergoing stereotactic body radiation therapy (SBRT). Patients selected for SBRT underwent 3-D or 4-D CT scans in a cust ... Full text Link to item Cite

On-line re-optimization of prostate IMRT plans for adaptive radiation therapy.

Journal article Phys Med Biol · February 7, 2008 For intermediate and high risk prostate cancer, both the prostate gland and seminal vesicles are included in the clinical target volume. Internal motion patterns of these two organs vary, presenting a challenge for adaptive treatment. Adaptive techniques s ... Full text Link to item Cite

Automatic registration between reference and on-board digital tomosynthesis images for positioning verification.

Journal article Med Phys · February 2008 The authors developed a hybrid multiresolution rigid-body registration technique to automatically register reference digital tomosynthesis (DTS) images with on-board DTS images to guide patient positioning in radiation therapy. This hybrid registration tec ... Full text Link to item Cite

Evaluation of Image Enhancement Method on Target Registration Using Cone Beam CT in Radiation Therapy.

Journal article Clin Med Oncol · 2008 An intensity based six-degree image registration algorithm between cone-beam CT (CBCT) and planning CT has been developed for image-guided radiation therapy (IGRT). CT images of an anthropomorphic chest phantom were acquired using conventional CT scanner a ... Full text Link to item Cite

An on-line adaptive radiation therapy system for intensity modulated radiation therapy: An application of multi-objective optimization

Journal article Journal of Industrial and Management Optimization · January 1, 2008 Radiation therapy (RT) is a non-invasive and highly ekective treatment option for Prostate cancer. The goal is to deliver the prescription dose to the tumor (prostate) while minimizing the damages to the surrounding healthy organs namely bladder, rectum, a ... Full text Cite

3-D deformation guided on-line modification of multi-leaf collimators for adaptive radiation therapy

Journal article Lecture Notes in Computer Science Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics · January 1, 2008 Adaptive radiation therapy (ART) requires an on-line modification of the treatment plan to compensate for the motion of organs. In this paper, an improved multi-leaf collimator (MLC) deformation approach is proposed to accurately compensate for the organ m ... Full text Cite

Cone-beam CT localization of internal target volumes for stereotactic body radiotherapy of lung lesions.

Journal article Int J Radiat Oncol Biol Phys · December 1, 2007 PURPOSE: In this study, we investigate a technique of matching internal target volumes (ITVs) in four-dimensional (4D) simulation computed tomography (CT) to the composite target volume in free-breathing on-board cone-beam (CB) CT. The technique is illustr ... Full text Link to item Cite

On-board patient positioning for head-and-neck IMRT: comparing digital tomosynthesis to kilovoltage radiography and cone-beam computed tomography.

Journal article Int J Radiat Oncol Biol Phys · October 1, 2007 PURPOSE: High-precision intensity-modulated radiotherapy demands high patient positioning accuracy. On-board digital tomosynthesis (DTS) provides three-dimensional (3D) image guidance for daily positioning with a lower imaging dose, faster acquisition, and ... Full text Link to item Cite

Evaluation of three types of reference image data for external beam radiotherapy target localization using digital tomosynthesis (DTS).

Journal article Med Phys · August 2007 Digital tomosynthesis (DTS) is a fast, low-dose three-dimensional (3D) imaging approach which yields slice images with excellent in-plane resolution, though low plane-to-plane resolution. A stack of DTS slices can be reconstructed from a single limited-ang ... Full text Link to item Cite

TU‐C‐T‐617‐01: A Computer Model for Automatic Planning and Optimization for Gamma Knife Radiosurgery Using Auto‐Positioning System

Journal article Medical Physics · January 1, 2005 Purpose: This research addresses the automatic‐planning of Gamma Knife radiosurgery using auto‐positioning system (APS). We previously reported a morphology‐guided automatic planning model via optimization of dose conformity and minimization of total numbe ... Full text Cite

Real-time inverse planning for Gamma Knife radiosurgery.

Journal article Med Phys · November 2003 Featured Publication The challenges of real-time Gamma Knife inverse planning are the large number of variables involved and the unknown search space a priori. With limited collimator sizes, shots have to be heavily overlapped to form a smooth prescription isodose line that co ... Full text Link to item Cite

Plug pattern optimization for gamma knife radiosurgery treatment planning.

Journal article Int J Radiat Oncol Biol Phys · February 1, 2003 PURPOSE: To develop a novel dose optimization algorithm for improving the sparing of critical structures during gamma knife radiosurgery by shaping the plug pattern of each individual shot. METHOD AND MATERIALS: We first use a geometric information (medial ... Full text Link to item Cite

Implementation of the isocenter-shift technique for smoothing MLC field edge on a 3D treatment planning system.

Journal article Med Phys · July 2002 Stepped leaf edges are the major limitation of conforming to the prescribed treatment contour defined by the conventional multileaf collimator (MLC), which produces a scalloped dose pattern. The commercial HD-270 MLC (HDI) technique provides a software sol ... Full text Link to item Cite

Megavoltage radiation dose response of digital computed radiography

Journal article Proceedings of SPIE the International Society for Optical Engineering · January 1, 2001 The response of a digital computed radiography system to the megavoltage therapeutic radiation beams was invested. A narrow slit of radiation beam was used to test the line spread function of the system. The effects of various facts such as cassette, beam ... Full text Cite

Improving spatial resolution of multileaf collimator defined radiation treatment field

Journal article Proceedings of SPIE the International Society for Optical Engineering · January 1, 2001 A prototype high definition multi-leaf collimator system (HDI) has been developed and installed on the linear accelerator for use in conformal radiotherapy. The HDI technique utilizes the dynamic shift of the 3D-target volume to feather the multi-leaf coll ... Full text Cite

GammaPlan-Leksell Gamma Knife radiosurgery treatment planning verification method.

Journal article Med Phys · September 2000 This work provides a method for an independent check of Gamma Knife GammaPlan radiosurgery calculations, named the spherical approximation method or SAM. Based on skull dimension measurements, the treated volume of the head is modeled as a sphere of radius ... Full text Link to item Cite

Three-dimensional treatment planning computer-based vs nomogram-based implant technique for prostate carcinoma

Journal article Journal of Brachytherapy International · January 1, 2000 The use of three-dimensional (3D) treatment planning computers for determining seed placement in prostate brachytherapy has become more widespread. This study compares the dosimetric differences between prostate implants performed by using 3D treatment pla ... Cite

Fast verification of Gamma Knifetrade mark treatment plans.

Journal article J Appl Clin Med Phys · 2000 The Leksell stereotactic Gamma Knifetrade mark uses radiation from 201 (60)Co sources that are focused to the center of a collimator helmet to deliver a high dose of radiation with minimal irradiation of proximal structures. This paper presents a method fo ... Full text Link to item Cite

Three-dimensional skeletonization for computer-assisted treatment planning in radiosurgery.

Journal article Comput Med Imaging Graph · 2000 This paper describes a new algorithm for skeletonization of two- (2D) and three-dimensional (3D) objects based on ridge extraction. Ridges are formed when grassfire fronts collapse during grassfire propagation and they correspond to the locus of skeleton. ... Full text Link to item Cite

A reliable intensity modulated radiation therapy approach with multiple opposed lateral fields for head and neck tumors

Journal article Annual International Conference of the IEEE Engineering in Medicine and Biology Proceedings · January 1, 2000 Multileaf collimators were applied to intensity modulated lateral fields to achieve a relatively homogeneous dose distribution in the head and neck region without using any wedges. Then the isodose distribution was compared with one planned with wedges. As ... Full text Cite

Morphology-guided radiosurgery treatment planning and optimization for multiple isocenters.

Journal article Med Phys · October 1999 Featured Publication This work merges two distinct fields, 3D morphology and ionizing radiation dosimetry, to solve the problem of 3D-treatment planning and optimization in stereotactic radiosurgery. In Leksell Gamma Knife radiosurgery, dose delivery is based on the unit "shot ... Full text Link to item Cite

The influence of x-ray energy on lung dose uniformity in total-body irradiation.

Journal article Int J Radiat Oncol Biol Phys · July 15, 1997 PURPOSE: In this study we examine the influence of x-ray energy on the uniformity of the dose within the lung in total-body irradiation treatments in which partial transmission blocks are used to control the lung dose. METHODS AND MATERIALS: A solid water ... Full text Link to item Cite

Morphology-guided radiotherapy treatment planning and optimization

Journal article Proceedings of SPIE the International Society for Optical Engineering · December 1, 1996 In gamma unit radiosurgery treatment planning, dose delivery is based on the unit 'shot,' a distribution of dose approximately spherical in shape. Multiple shots are used to cover different parts of a given target region. Effective 3D optimization for gamm ... Full text Cite

Fast 3D medial axis transformation to reduce computation and complexity in radiosurgery treatment planning

Journal article Proceedings of SPIE the International Society for Optical Engineering · December 1, 1996 The medial axis analysis of an object can be used to effectively guide and optimize radiosurgery treatment planning. In this paper, a fast Euclidean medial axis transformation in three dimensions based on dynamic grassfire simulation and ridge extraction i ... Full text Cite