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Jadee Lee Neff

Assistant Professor of Pathology
Pathology
40 Duke Medicine Circle, DUMC 3712, Durham, NC 27710

Overview


As a diagnostic hematopathologist and molecular genetic pathologist, my clinical interests are focused on the histologic examination of tissue and bone marrow biopsies to diagnose hematologic malignancies (leukemia, lymphoma, myeloma, etc.) as well as testing DNA from tumors or from blood to detect inherited or acquired mutations that can guide therapeutic management and predict clinical outcome.  My research interests involve 1) understanding the biology of T-cell and NK-cell neoplasms; 2) defining the immunomodulatory response to neoplastic disease; 3) developing methods to monitor immune response and thereby refine tumor immunotherapy; and 4) exploring novel applications of tumor genetics in the diagnosis, prognosis, and management of cancer.

Current Appointments & Affiliations


Assistant Professor of Pathology · 2021 - Present Pathology, Clinical Science Departments
Member of the Duke Cancer Institute · 2020 - Present Duke Cancer Institute, Institutes and Centers

Recent Publications


Associations between molecular classification and response to intra-uterine levonorgestrel device therapy in patients with medically managed endometrial cancer and endometrial intra-epithelial neoplasia: a multi-center Endometrial Cancer Molecularly Targeted Therapy (ECMT2) Consortium study.

Journal Article Int J Gynecol Cancer · April 29, 2026 OBJECTIVE: To determine the association between molecular classification and response in patients with endometrial intra-epithelial neoplasia or endometrial cancer treated with a levonorgestrel intra-uterine device. METHODS: Eligible patients were treated ... Full text Link to item Cite

Spatial proteomics of breast ductal carcinoma in situ reveal distinct regional differences.

Journal Article Sci Rep · March 13, 2026 UNLABELLED: Breast ductal carcinoma in situ is a common non-invasive clinical finding that can progress to invasive breast cancer (IBC). Spatial proteomics can provide an additional dimension to our understanding of this disease and its capacity to progres ... Full text Link to item Cite

Distinct B/myeloid and T-lymphoblast populations at separate anatomic sites in mixed-phenotype acute leukemia with BCR::ABL1 fusion.

Journal Article J Hematop · September 22, 2025 The pluripotency of malignant blasts in acute leukemias is a growing area of scientific and clinical interest. Mixed-phenotype acute leukemias (MPALs) are defined by the presence of blasts showing evidence of differentiation along at least two lineages. Cu ... Full text Open Access Link to item Cite
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Recent Grants


Pathways of Injury and Repair in Barrett's Carcinogenesis Core 2: Biospecimens & Reagents Core

ResearchCo Investigator · Awarded by Case Western Reserve University · 2023 - 2027

View All Grants

Education


Mayo Clinic, Alix School of Medicine · 2011 M.D.
Mayo Clinic, Alix School of Medicine · 2007 Ph.D.