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Jadee Lee Neff

Assistant Professor of Pathology
Pathology
40 Duke Medicine Circle, DUMC 3712, Durham, NC 27710

Overview


As a diagnostic hematopathologist and molecular genetic pathologist, my clinical interests are focused on the histologic examination of tissue and bone marrow biopsies to diagnose hematologic malignancies (leukemia, lymphoma, myeloma, etc.) as well as testing DNA from tumors or from blood to detect inherited or acquired mutations that can guide therapeutic management and predict clinical outcome.  My research interests involve 1) understanding the biology of T-cell and NK-cell neoplasms; 2) defining the immunomodulatory response to neoplastic disease; 3) developing methods to monitor immune response and thereby refine tumor immunotherapy; and 4) exploring novel applications of tumor genetics in the diagnosis, prognosis, and management of cancer.

Current Appointments & Affiliations


Assistant Professor of Pathology · 2021 - Present Pathology, Clinical Science Departments
Member of the Duke Cancer Institute · 2020 - Present Duke Cancer Institute, Institutes and Centers

Recent Publications


Distinct B/myeloid and T-lymphoblast populations at separate anatomic sites in mixed-phenotype acute leukemia with BCR::ABL1 fusion.

Journal Article J Hematop · September 22, 2025 The pluripotency of malignant blasts in acute leukemias is a growing area of scientific and clinical interest. Mixed-phenotype acute leukemias (MPALs) are defined by the presence of blasts showing evidence of differentiation along at least two lineages. Cu ... Full text Open Access Link to item Cite

Paired single-cell and spatial transcriptional profiling reveals a central osteopontin macrophage response mediating tuberculous granuloma formation.

Journal Article mBio · September 10, 2025 Granulomas are classic manifestations of tuberculosis pathogenesis. They result from an ensemble of immune responses to Mycobacterium tuberculosis infection, but the identities, arrangement, cellular interactions, and regulation of the cells that comprise ... Full text Link to item Cite

Cathepsin Z is a conserved susceptibility factor underlying tuberculosis severity.

Journal Article PLoS Biol · September 2025 Tuberculosis (TB) outcomes vary widely, from asymptomatic infection to mortality, yet most animal models do not recapitulate human phenotypic and genotypic variation. The genetically diverse Collaborative Cross mouse panel models distinct facets of TB dise ... Full text Link to item Cite
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Recent Grants


Cooperative Human Tissue Network Support through Duke's BioRepository & Precision Pathology Center

ResearchCo Investigator · Awarded by National Cancer Institute · 2019 - 2029

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Education, Training & Certifications


Mayo Clinic, Alix School of Medicine · 2011 M.D.
Mayo Clinic, Alix School of Medicine · 2007 Ph.D.