Scholars@Duke
Glenn Jay Jaffe

Glenn Jay Jaffe

Robert Machemer M.D. Distinguished Professor of Ophthalmology
Ophthalmology, Vitreoretinal Diseases & Surgery
Box 3802 Med Ctr, Durham, NC 27710
Duke Eye Center, 2351 Erwin Ro, Durham, NC 27710

Scholarly Works - Conferences

Onset of End-Stage Atrophic Age-Related Macular Degeneration as an End Point-A Delphi Study: Classification of Atrophy Meetings Report 7.

Conference Ophthalmol Sci · 2025 PURPOSE: To investigate whether consensus can be reached on the acceptability of end-stage atrophy onset as a clinical end point in early intervention trials of age-related macular degeneration (AMD), and the criteria for defining such an end point. DESIGN ... Full text Link to item Cite

HAWK and HARRIER: Ninety-Six-Week Outcomes from the Phase 3 Trials of Brolucizumab for Neovascular Age-Related Macular Degeneration.

Conference Ophthalmology · January 2021 PURPOSE: To report the 96-week outcomes from HAWK and HARRIER. DESIGN: Phase 3, prospective, randomized, double-masked, multicenter studies comparing efficacy and safety of brolucizumab 3 mg (HAWK only) and 6 mg with aflibercept 2 mg in eyes with neovascul ... Full text Link to item Cite

BASELINE CHARACTERISTICS OF VITREOMACULAR TRACTION PROGRESSING TO FULL-THICKNESS MACULAR OR LAMELLAR HOLES IN THE PHASE III TRIALS OF ENZYMATIC VITREOLYSIS.

Conference Retina · August 2020 PURPOSE: To identify characteristics associated with progression from vitreomacular traction (VMT) to a full-thickness macular hole (FTMH) or lamellar hole (LH). METHODS: Post-hoc analysis of the Phase III clinical trial comparing ocriplasmin with placebo ... Full text Link to item Cite

Clinical outcomes following the triple procedure

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · July 1, 2019 Link to item Cite

Luminate protects against hydroquinone-induced injury in human RPE cells

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · July 1, 2019 Link to item Cite

Macular Morphology and Visual Acuity in Year Five of the Comparison of Age-related Macular Degeneration Treatments Trials.

Conference Ophthalmology · February 2019 PURPOSE: To evaluate associations of morphologic features with 5-year visual acuity (VA) in the Comparison of Age-related Macular Degeneration Treatments Trials (CATT). DESIGN: Cohort study within a randomized clinical trial. PARTICIPANTS: Participants in ... Full text Link to item Cite

Semi-Automated Segmentation of Hyperreflective Foci on Optical Coherence Tomography

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · July 1, 2018 Link to item Cite

Phase 2 Trial of Ciliary Neurotrophic Factor for Macular Telangiectasia Type 2

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · July 1, 2018 Link to item Cite

Effect of Bax Inhibitor 1 overexpression on Tunicamycin-induced ER Stress in Human RPE Cells

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 1, 2017 Link to item Cite

Complement Membrane Attack Complex Release Basic Fibroblast Growth Factor from Human RPE Cells

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 1, 2017 Link to item Cite

Baseline Predictors of Five-Year Visual Acuity in the Comparison of AMD Treatment Trials (CATT)

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 1, 2017 Link to item Cite

Cystoid Macular Edema as a Marker in the Progression of Autoimmune Retinopathy

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 1, 2017 Link to item Cite

Intravitreal Aflibercept for Diabetic Macular Edema: 148-Week Results from the VISTA and VIVID Studies.

Conference Ophthalmology · November 2016 PURPOSE: To compare efficacy and safety of intravitreal aflibercept injection (IAI) with macular laser photocoagulation for diabetic macular edema (DME) over 3 years. DESIGN: Two similarly designed phase 3 trials: VISTADME and VIVIDDME. PARTICIPANTS: Patie ... Full text Link to item Cite

The Protective Effect of Bax Inhibitor 1 (BI-1) on Tunicamycin-induced Human RPE Cell Death

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · September 1, 2016 Link to item Cite

The Association of Apolipoprotein E and Membrane Attack Complex in Human RPE Cell

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · September 1, 2016 Link to item Cite

Adalimumab in patients with active and inactive, non-infectious uveitis: VISUAL I and VISUAL II trials

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · September 1, 2016 Link to item Cite

Complement-mediated Apolipoprotein E Accumulation in Cultured Human RPE Cell

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 1, 2015 Link to item Cite

Lab-on-a-disk immunoassay for ocular diagnostics

Conference Proceedings of the IEEE Annual Northeast Bioengineering Conference Nebec · December 2, 2014 Monitoring of angiogenic cytokines in the eyes of patients with diabetic retinopathy (DR) and age-related macular degeneration (AMD) is crucial to confirm efficacy of treatment. We present a novel 'lab-on-a-disk' immunoassay for monitoring vascular endothe ... Full text Cite

"Smart" co-drugs. Rapid intravitreal delivery of 5-FU and prolonged delivery of steroid from the same erodible device

Conference Investigative Ophthalmology and Visual Science · December 1, 1997 Purpose: The aim of this work was to develop a small implantahle hioerodihle device giving sustained release of 5-FU for 1-2 weeks and sustained release of a steroid for over 2 months. Previous work had indicated that this may be optimal for the treatment ... Cite

Short and long term exposure of intraocular lenses to silicone oil after vitrectomy and silicone oil tamponade

Conference Investigative Ophthalmology and Visual Science · December 1, 1997 Purpose: Silicone oil is frequently used as a vitreous substitute after complex vitreoretinal procedures. We sought to study the effect of short and long term exposure to silicone oil on polymethylmethacrylate (PMMA[Alcon MC60BM1), silicone (AMO SI-30NB) a ... Cite

Development of a 1.5 year ganciclovir implant for CMV retinitis

Conference Investigative Ophthalmology and Visual Science · February 15, 1996 Purpose: To develop an implantable device giving sustained release of ganciclovir (GCV) over 1.5 years. Methods. Short rod like pellets of GCV were prepared by compressing 30 mg of GCV in a 2 mm tablet die. Pellets were then coated in a solution of 98% hyd ... Cite

Efficacy and pharmacokinetics of intravitreal sustained release triamcinolone/5-FU codrug suspension in the treatment of experimental PVR

Conference Investigative Ophthalmology and Visual Science · February 15, 1996 Purpose. Last year we described a novel method of delivering a triamcinolone acetonide (TA)/5-FU conjugate as a sustained release suspension for the treatment of PVR in a fibroblast -injection model. Herein, we evaluate the pharmacokinetics and efficacy of ... Cite

Pharmacologic inhibition of experimental proliferative vitreoretinopathy (PVR) using a triamcinolone/5-fluorouracil codrug sustained release pellet

Conference Investigative Ophthalmology and Visual Science · February 15, 1996 Purpose: We have previously evaluated the efficacy of a novel dexamethasone/5-fluorouracil (5-FU) codrug pellet in the treatment of PVR. This prepararion was not fully effective because of the drug's high solubility and relatively fast release rate. In thi ... Cite

Condensation on polymethylmethacrylate, acrylic polymer and silicone intraocular lenses after vitrectomy and fluid-air exchange

Conference Investigative Ophthalmology and Visual Science · February 15, 1996 Purpose: Condensation on the posterior surface of intraocular lenses can markedly compromise the retinal view during vitrectomy and fluid-air exchange. In this study, we compared the condensation and subsequent retinal view degradation after vitrectomy and ... Cite