Glenn Jay Jaffe

Journal article Am J Ophthalmol · July 2003 Featured Work PURPOSE: To report the sensitivity and specificity of B-scan ultrasonography to detect macular thickening. DESIGN: Observational case series. METHODS: Seventy-seven eyes of 40 consecutive patients (age range, 7-80 years) in a retinal specialty practice wer ... Full text Link to item Cite

Aquaporin-1 channels in human retinal pigment epithelium: role in transepithelial water movement.

Journal article Invest Ophthalmol Vis Sci · June 2003 Featured Work PURPOSE: Aquaporin (AQP) is a hexahelical integral membrane protein that functions as a constitutive channel for water and regulated channel for cations in fluid transporting tissues, including many in the eye. Although AQP1 has been cloned from a cDNA lib ... Full text Link to item Cite

Effect of mutant IkappaB on cytokine-induced activation of NF-kappaB in cultured human RPE cells.

Journal article Invest Ophthalmol Vis Sci · March 2003 Featured Work PURPOSE: The nuclear transcription factor (NF)-kappaB is a central regulator of multiple inflammatory cytokines. The current study was conducted to determine whether infection of human retinal pigment epithelial (RPE) cells by adenovirus carrying a mutant ... Full text Link to item Cite

Modified external needle drainage procedure for rhegmatogenous retinal detachment.

Journal article Retina · February 2003 Featured Work PURPOSE: To describe the results of a modified external needle subretinal fluid drainage technique to treat eyes with a rhegmatogenous retinal detachment. METHODS: One hundred eighty-seven consecutive patients with a rhegmatogenous retinal detachment who u ... Full text Link to item Cite

Effect of INS37217, a P2Y(2) receptor agonist, on experimental retinal detachment and electroretinogram in adult rabbits.

Journal article Invest Ophthalmol Vis Sci · November 2002 Featured Work PURPOSE: To evaluate the effects of subretinal and intravitreal delivery of INS37217, a P2Y(2) receptor agonist, on subretinal fluid reabsorption in experimentally induced retinal detachments in rabbits, and to characterize the effects of INS37217 on elect ... Link to item Cite

Diagnostic yield of vitrectomy in eyes with suspected posterior segment infection or malignancy.

Journal article Ophthalmology · June 2002 Featured Work PURPOSE: To determine the yield of diagnostic pars plana vitrectomy in eyes with suspected posterior segment inflammation or malignancy when clinical examination and systemic laboratory testing did not yield a specific diagnosis. DESIGN: Non-comparative in ... Full text Link to item Cite

Fluocinolone acetonide sustained drug delivery device to treat severe uveitis.

Journal article Ophthalmology · November 2000 Featured Work PURPOSE: Uveitis is often a chronic disease requiring long-term medical therapy. In this report, we describe a pilot safety and efficacy trial of a novel sustained drug delivery system containing fluocinolone acetonide to treat patients with severe uveitis ... Full text Link to item Cite

Safety and pharmacokinetics of an intraocular fluocinolone acetonide sustained delivery device.

Journal article Invest Ophthalmol Vis Sci · October 2000 Featured Work PURPOSE: To determine the safety and pharmacokinetics of an intraocular fluocinolone acetonide sustained drug delivery device. METHODS: Nonbiodegradable drug delivery devices containing 2 or 15 mg of a synthetic corticosteroid, fluocinolone acetonide, were ... Link to item Cite

An intravitreal sustained-release triamcinolone and 5-fluorouracil codrug in the treatment of experimental proliferative vitreoretinopathy.

Journal article Arch Ophthalmol · January 1998 Featured Work OBJECTIVE: To determine the efficacy and pharmacokinetics of an intravitreal sustained-release triamcinolone acetonide and 5-fluorouracil (TA/5-FU) codrug in the treatment of experimental proliferative vitreoretinopathy (PVR). METHODS: The therapeutic effi ... Full text Link to item Cite

Intravitreal sustained-release cyclosporine in the treatment of experimental uveitis.

Journal article Ophthalmology · January 1998 Featured Work OBJECTIVE: Uveitis often is a chronic disease requiring long-term medical therapy. Despite treatment, the disease may be difficult to control and may produce serious, vision-threatening ocular complications. In this study, the authors determined whether an ... Full text Link to item Cite

Uveitis in the southeastern United States.

Journal article Curr Eye Res · September 1997 Featured Work PURPOSE: Previous epidemiologic studies of uveitis have focused on predominantly Caucasian populations, and none have been based in the Southeast. We analyzed the epidemiology of uveitis among a referral population with a high percentage of African America ... Full text Link to item Cite

Expression of CD44 and variant isoforms in cultured human retinal pigment epithelial cells.

Journal article Invest Ophthalmol Vis Sci · September 1997 Featured Work PURPOSE: CD44 is a major hyaluronic acid receptor that exists as a number of isoforms, generated by alternative splicing of 9 "variant" exons in humans (v2 to v10) and 10 exons in rodents. Little is known about the expression and function of CD44 in human ... Link to item Cite

Tissue plasminogen activator for postvitrectomy fibrin formation.

Journal article Ophthalmology · February 1990 Featured Work The authors injected 25 micrograms of recombinant tissue plasminogen activator (tPA) into the anterior chamber or vitreous cavity of 23 eyes of 22 patients with severe intraocular fibrin formation that developed after vitrectomy surgery for complicated cas ... Full text Link to item Cite