Current Appointments & Affiliations
Adjunct Assistant Professor in the Department of Pharmacology and Cancer Biology
·
2022 - Present
Pharmacology & Cancer Biology,
Basic Science Departments
Recent Publications
Oxidative Phosphorylation Is a Metabolic Vulnerability of Endocrine Therapy-Tolerant Persister Cells in ER+ Breast Cancer.
Journal Article Cancer Res · March 14, 2025 Despite adjuvant treatment with endocrine therapies, estrogen receptor-positive (ER+) breast cancers recur in a significant proportion of patients. Recurrences are attributable to clinically undetectable endocrine-tolerant persister cancer cells that retai ... Full text Link to item CiteCorrection: Oncogenic Transformation by Inhibitor-Sensitive and -Resistant EGFR Mutants.
Journal Article PLoS Med · September 2024 [This corrects the article DOI: 10.1371/journal.pmed.0020313.]. ... Full text Link to item CiteOptical imaging reveals chemotherapy-induced metabolic reprogramming of residual disease and recurrence.
Journal Article Sci Adv · April 5, 2024 Fewer than 20% of triple-negative breast cancer patients experience long-term responses to mainstay chemotherapy. Resistant tumor subpopulations use alternative metabolic pathways to escape therapy, survive, and eventually recur. Here, we show in vivo, lon ... Full text Link to item CiteRecent Grants
Defining the role of the histone methyltransferase G9a in mitigating replication stress in cancer
FellowshipPrincipal Investigator · Awarded by Howard Hughes Medical Institute · 2020 - 2023Pathways regulating dormant cell survival and recurrence
ResearchPrincipal Investigator · Awarded by American Cancer Society, Inc. · 2019 - 2021Exploring the role of polyploidy in tumor progression
FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2019 - 2021View All Grants
Education, Training & Certifications
Harvard Medical School ·
2005
Ph.D.
Pennsylvania State University ·
1999
B.S.