James Taylor Herbert

Journal article J Trauma Acute Care Surg · August 1, 2026 BACKGROUND: Endotracheal intubation is the most common airway intervention in the deployed combat setting, including far-forward Role 1 battalion aid stations. Intubation in this setting is often performed by novice intubators, adding to the complexity of ... Full text Link to item Cite

Temperature Control After In-Hospital Cardiac Arrest: Outcomes From the Discover In-Hospital Cardiac Arrest Cohort.

Journal article Crit Care Med · June 1, 2026 OBJECTIVES: A temperature control strategy is strongly recommended for comatose in-hospital cardiac arrest (IHCA) survivors. We aimed to investigate variation in adherence to this recommendation and associations with outcomes, which have not been comprehen ... Full text Link to item Cite

Blade Size and Outcomes With Standard-Geometry Video Laryngoscopy in Emergency Tracheal Intubations: Secondary Analysis of 2 Randomized Controlled Trials

Journal article Chest Critical Care · June 1, 2026 Background: Laryngoscope blade size may affect successful intubation on the first attempt, but evidence to inform the optimal blade size for standard-geometry curved video laryngoscopes (VLs) in critically ill adults is limited. Research Question: Does the ... Full text Cite

Apolipoprotein E Mimetic Peptide CN-105 and Postoperative Delirium in Older Patients: The Phase 2 MARBLE Randomized Clinical Trial.

Journal article JAMA Netw Open · April 1, 2026 IMPORTANCE: The apolipoprotein E (APOE) gene ε4 allele leads to increased Alzheimer disease risk and neuroinflammation and is also believed to play a role in postoperative delirium. However, the safety and feasibility of modulating apoE protein signaling t ... Full text Link to item Cite

Video vs Direct Laryngoscopy for Tracheal Intubation After Cardiac Arrest: A Secondary Analysis of the Direct vs Video Laryngoscope Trial.

Journal article Chest · May 2025 BACKGROUND: Airway management is a critical component of the care of patients experiencing cardiac arrest, but data from randomized trials on the use of video vs direct laryngoscopy for intubation in the setting of cardiac arrest are limited. Current Ameri ... Full text Link to item Cite

Association Between Neuromuscular Blocking Agents and Outcomes of Emergency Tracheal Intubation: A Secondary Analysis of Randomized Trials.

Journal article Ann Emerg Med · January 2025 STUDY OBJECTIVE: To examine the association between the neuromuscular blocking agent received (succinylcholine versus rocuronium) and the incidences of successful intubation on the first attempt and severe complications during tracheal intubation of critic ... Full text Link to item Cite

The Discover In-Hospital Cardiac Arrest (Discover IHCA) Study: An Investigation of Hospital Practices After In-Hospital Cardiac Arrest.

Journal article Crit Care Explor · September 1, 2024 IMPORTANCE: In-hospital cardiac arrest (IHCA) is a significant public health burden. Rates of return of spontaneous circulation (ROSC) have been improving, but the best way to care for patients after the initial resuscitation remains poorly understood, and ... Full text Link to item Cite

Video versus Direct Laryngoscopy for Tracheal Intubation of Critically Ill Adults.

Journal article N Engl J Med · August 3, 2023 BACKGROUND: Whether video laryngoscopy as compared with direct laryngoscopy increases the likelihood of successful tracheal intubation on the first attempt among critically ill adults is uncertain. METHODS: In a multicenter, randomized trial conducted at 1 ... Full text Link to item Cite

Point-of-Care Lung Ultrasound in Adults: Image Acquisition.

Journal article J Vis Exp · March 3, 2023 Consultative ultrasound performed by radiologists has traditionally not been used for imaging the lungs, as the lungs' air-filled nature normally prevents direct visualization of the lung parenchyma. When showing the lung parenchyma, ultrasound typically g ... Full text Link to item Cite

DirEct versus VIdeo LaryngosCopE (DEVICE): protocol and statistical analysis plan for a randomised clinical trial in critically ill adults undergoing emergency tracheal intubation.

Journal article BMJ Open · January 13, 2023 INTRODUCTION: Among critically ill patients undergoing orotracheal intubation in the emergency department (ED) or intensive care unit (ICU), failure to visualise the vocal cords and intubate the trachea on the first attempt is associated with an increased ... Full text Link to item Cite

Variation in Fluid and Vasopressor Use in Shock With and Without Physiologic Assessment: A Multicenter Observational Study.

Journal article Crit Care Med · October 2020 OBJECTIVES: To characterize the association between the use of physiologic assessment (central venous pressure, pulmonary artery occlusion pressure, stroke volume variation, pulse pressure variation, passive leg raise test, and critical care ultrasound) wi ... Full text Link to item Cite

Evaluation of Vasopressor Exposure and Mortality in Patients With Septic Shock.

Journal article Crit Care Med · October 2020 OBJECTIVES: The objectives of this study were to: 1) determine the association between vasopressor dosing intensity during the first 6 hours and first 24 hours after the onset of septic shock and 30-day in-hospital mortality; 2) determine whether the effec ... Full text Link to item Cite

Transesophageal Echocardiography Use in Diagnosis and Management of Embolized Intravascular Foreign Bodies.

Journal article Semin Cardiothorac Vasc Anesth · March 2018 The increasing use of endovascular interventions coupled with the large number of published case series detailing complications attest to the likelihood that anesthesiologists will encounter a case of intravascular foreign body embolization during their ca ... Full text Link to item Cite

Raising the pressure: Hemodynamic effects of splanchnic nerve stimulation.

Journal article J Appl Physiol (1985) · July 1, 2017 A number of cardiovascular and neurological diseases are characterized by a dysregulation of intravascular volume distribution. The veins and arteries of the visceral organs form the so-called splanchnic vascular compartment and are the largest reservoir f ... Full text Link to item Cite

MYC activity mitigates response to rapamycin in prostate cancer through 4EBP1-mediated inhibition of autophagy.

Journal article Autophagy · February 2010 Cancer cells have evolved exquisitely to ignore both intrinsic and extrinsic cell death signals, and resistance to cell death is a critical challenge facing clinical oncology. Autophagy, the catabolic recycling process that involves the fusion of autophago ... Full text Link to item Cite

Activation of cap-independent translation by variant eukaryotic initiation factor 4G in vivo.

Journal article RNA · October 2008 Protein synthesis is tightly controlled by assembly of an intricate ribonucleoprotein complex at the m(7)GTP-cap on eukaryotic mRNAs. Ensuing linear scanning of the 5' untranslated region (UTR) is believed to transfer the preinitiation complex to the initi ... Full text Link to item Cite

Treatment of cerebellar granule cell neurons with the neurotrophic factor pigment epithelium-derived factor in vitro enhances expression of other neurotrophic factors as well as cytokines and chemokines.

Journal article J Neurosci Res · September 1, 2004 Microarray analyses demonstrated that a variety of genes was affected by treatment of cerebellar granule cell neurons with the neurotrophic factor pigment epithelium-derived factor (PEDF). The genes for neurotrophins, glial cell-derived neurotrophic factor ... Full text Link to item Cite

Effect of strain and sex on mu opioid receptor-mediated G-protein activation in rat brain.

Journal article Brain Res Bull · May 15, 2003 Strain and sex differences in mu opioid-mediated antinociception have been reported in rodents. The present studies evaluated mu opioid receptor-mediated G-protein activation in Lewis and Fischer 344 (F344) male and female rats using agonist-stimulated [35 ... Full text Link to item Cite

Research jobs for recent college graduates: A comparison between traditional lab technician positions and NIH's postbaccalaureate IRTA fellowship.

Journal article J Undergrad Neurosci Educ · 2003 The features that distinguish the Postbaccalaureate IRTA experience from a normal lab tech job are the enhanced educational opportunities, greater independence, more organized social outlets and networking opportunities, life in the DC Metro area, and the ... Link to item Cite