James Patrick White Jr. | Scholars@Duke

James Patrick White Jr.
Assistant Professor in Medicine

Current Appointments & Affiliations

Assistant Professor in Medicine, Medicine, Hematology, Medicine 2021
Assistant Research Professor in Cell Biology, Cell Biology, Basic Science Departments 2019
Member of Duke Molecular Physiology Institute, Duke Molecular Physiology Institute, Duke Molecular Physiology Institute 2016
Senior Fellow in the Center for the Study of Aging, Center for the Study of Aging and Human Development, Institutes and Centers 2016
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2019
Affiliate of the Duke Regeneration Center, Regeneration Next Initiative, Basic Science Departments 2021

Contact Information

james.white@duke.edu

Background
Education, Training, & Certifications
- Postdoctoral Fellow, Harvard Medical School 2011 - 2014
- Ph.D., University of South Carolina, Columbia 2010
- M.S., Florida State University 2005
Previous Appointments & Affiliations
- Assistant Professor in Medicine, Medicine, Hematology, Medicine 2016 - 2020
Research
Selected Grants
- Hematology & Transfusion Medicine (T32) awarded by National Institutes of Health 1975 - 2026
- Studies on the Mechanisms by which SIRT5 Regulates Aging and Disease awarded by National Institutes of Health 2019 - 2024
- Assessing healthspan in aged mice after prolonged exposure to young circulation awarded by National Institutes of Health 2020 - 2023
- The AMPK/ULK1/p27Kip1 axis regulates autophagy and cell survival in aged satellite cells awarded by National Institutes of Health 2017 - 2023
- Genomic Analysis of the CALERIE Trial to Generate New Knowledge for Geroscience awarded by Columbia University 2019 - 2023
- Correction of Immune Response Improves Aged Fracture Healing awarded by National Institutes of Health 2020 - 2022
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Lee, David E., Lauren K. McKay, Akshay Bareja, Yongwu Li, Alastair Khodabukus, Nenad Bursac, Gregory A. Taylor, Gurpreet S. Baht, and James P. White. “Meteorin-like is an injectable peptide that can enhance regeneration in aged muscle through immune-driven fibro/adipogenic progenitor signaling.” Nature Communications 13, no. 1 (December 2022): 7613. https://doi.org/10.1038/s41467-022-35390-3.
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  - Huang, Rong, Abhinav R. Balu, Kristin H. Molitoris, James P. White, Alexander G. Robling, Ugur M. Ayturk, and Gurpreet S. Baht. “The role of Meteorin-like in skeletal development and bone fracture healing.” J Orthop Res 40, no. 11 (November 2022): 2510–21. https://doi.org/10.1002/jor.25286.
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  - Zhao, Meng, Niels Banhos Danneskiold-Samsøe, Livia Ulicna, Quennie Nguyen, Laetitia Voilquin, David E. Lee, James P. White, et al. “Phosphoproteomic mapping reveals distinct signaling actions and activation of muscle protein synthesis by Isthmin-1.” Elife 11 (September 28, 2022). https://doi.org/10.7554/eLife.80014.
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  - White, James P., and Wenjing Du. “Career pathways, part 6.” Nat Metab 3, no. 10 (October 2021): 1277–79. https://doi.org/10.1038/s42255-021-00475-8.
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  - Pandey, Ambarish, Sanjiv J. Shah, Javed Butler, Dean L. Kellogg, Gregory D. Lewis, Daniel E. Forman, Robert J. Mentz, et al. “Exercise Intolerance in Older Adults With Heart Failure With Preserved Ejection Fraction: JACC State-of-the-Art Review.” J Am Coll Cardiol 78, no. 11 (September 14, 2021): 1166–87. https://doi.org/10.1016/j.jacc.2021.07.014.
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  - McKay, Lauren K., and James P. White. “The AMPK/p27Kip1 Pathway as a Novel Target to Promote Autophagy and Resilience in Aged Cells.” Cells 10, no. 6 (June 8, 2021). https://doi.org/10.3390/cells10061430.
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  - White, J. P. “Amino Acid Trafficking and Skeletal Muscle Protein Synthesis: A Case of Supply and Demand.” Frontiers in Cell and Developmental Biology 9 (May 31, 2021). https://doi.org/10.3389/fcell.2021.656604.
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  - Bareja, Akshay, James A. Draper, Lauren H. Katz, David E. Lee, Paul A. Grimsrud, and James P. White. “Chronic caloric restriction maintains a youthful phosphoproteome in aged skeletal muscle.” Mech Ageing Dev 195 (April 2021): 111443. https://doi.org/10.1016/j.mad.2021.111443.
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  - Huffman, Kim M., Brian J. Andonian, Dennis M. Abraham, Akshay Bareja, David E. Lee, Lauren H. Katz, Janet L. Huebner, William E. Kraus, and James P. White. “Exercise protects against cardiac and skeletal muscle dysfunction in a mouse model of inflammatory arthritis.” J Appl Physiol (1985) 130, no. 3 (March 1, 2021): 853–64. https://doi.org/10.1152/japplphysiol.00576.2020.
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  - Baht, Gurpreet S., Akshay Bareja, David E. Lee, Rajesh R. Rao, Rong Huang, Janet L. Huebner, David B. Bartlett, et al. “Author Correction: Meteorin-like facilitates skeletal muscle repair through a Stat3/IGF-1 mechanism.” Nat Metab 2, no. 8 (August 2020): 794. https://doi.org/10.1038/s42255-020-0257-y.
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  - Baht, Gurpreet S., Akshay Bareja, David E. Lee, Rajesh R. Rao, Rong Huang, Janet L. Huebner, David B. Bartlett, et al. “Meteorin-like facilitates skeletal muscle repair through a Stat3/IGF-1 mechanism.” Nat Metab 2, no. 3 (March 2020): 278–89. https://doi.org/10.1038/s42255-020-0184-y.
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  - Colón-Emeric, Cathleen, Heather E. Whitson, Sarah D. Berry, Roger A. Fielding, Denise K. Houston, Douglas P. Kiel, Clifford J. Rosen, et al. “AGS and NIA Bench-to Bedside Conference Summary: Osteoporosis and Soft Tissue (Muscle and Fat) Disorders.” J Am Geriatr Soc 68, no. 1 (January 2020): 31–38. https://doi.org/10.1111/jgs.16248.
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  - Huang, Rong, Xiaohua Zong, Puviindran Nadesan, Janet L. Huebner, Virginia B. Kraus, James P. White, Phillip J. White, and Gurpreet S. Baht. “Lowering circulating apolipoprotein E levels improves aged bone fracture healing.” Jci Insight 4, no. 18 (September 19, 2019). https://doi.org/10.1172/jci.insight.129144.
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  - Lee, David E., Akshay Bareja, David B. Bartlett, and James P. White. “Autophagy as a Therapeutic Target to Enhance Aged Muscle Regeneration.” Cells 8, no. 2 (February 2019): E183. https://doi.org/10.3390/cells8020183.
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  - Bareja, Akshay, David E. Lee, and James P. White. “Maximizing Longevity and Healthspan: Multiple Approaches All Converging on Autophagy.” Front Cell Dev Biol 7 (2019): 183. https://doi.org/10.3389/fcell.2019.00183.
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  - Zhou, Jin, Daniel C. Parker, James P. White, Andrea Lim, Kim M. Huffman, Jia Pei Ho, Paul M. Yen, and William E. Kraus. “Thyroid Hormone Status Regulates Skeletal Muscle Response to Chronic Motor Nerve Stimulation.” Front Physiol 10 (2019): 1363. https://doi.org/10.3389/fphys.2019.01363.
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  - Vi, Linda, Gurpreet S. Baht, Erik J. Soderblom, Heather Whetstone, Qingxia Wei, Bridgette Furman, Vijitha Puviindran, et al. “Macrophage cells secrete factors including LRP1 that orchestrate the rejuvenation of bone repair in mice.” Nat Commun 9, no. 1 (December 5, 2018): 5191. https://doi.org/10.1038/s41467-018-07666-0.
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  - White, James P., Andrew N. Billin, Milton E. Campbell, Alan J. Russell, Kim M. Huffman, and William E. Kraus. “The AMPK/p27Kip1 Axis Regulates Autophagy/Apoptosis Decisions in Aged Skeletal Muscle Stem Cells.” Stem Cell Reports 11, no. 2 (August 14, 2018): 425–39. https://doi.org/10.1016/j.stemcr.2018.06.014.
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  - Khandekar, Melin J., Alexander S. Banks, Dina Laznik-Bogoslavski, James P. White, Jang Hyun Choi, Lawrence Kazak, James C. Lo, et al. “Noncanonical agonist PPARγ ligands modulate the response to DNA damage and sensitize cancer cells to cytotoxic chemotherapy.” Proc Natl Acad Sci U S A 115, no. 3 (January 16, 2018): 561–66. https://doi.org/10.1073/pnas.1717776115.
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  - White, J. P. “IL-6, cancer and cachexia: Metabolic dysfunction creates the perfect storm.” Translational Cancer Research 6 (March 1, 2017): S280–85. https://doi.org/10.21037/tcr.2017.03.52.
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  - Liebscher, Ines, Brian Ackley, Demet Araç, Donna M. Ariestanti, Gabriela Aust, Byoung-il Bae, Bigyan R. Bista, et al. “New functions and signaling mechanisms for the class of adhesion G protein-coupled receptors.” Ann N Y Acad Sci 1333, no. 1 (December 2014): 43–64. https://doi.org/10.1111/nyas.12580.
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  - White, James P., Christiane D. Wrann, Rajesh R. Rao, Sreekumaran K. Nair, Mark P. Jedrychowski, Jae-Sung You, Vicente Martínez-Redondo, et al. “G protein-coupled receptor 56 regulates mechanical overload-induced muscle hypertrophy.” Proc Natl Acad Sci U S A 111, no. 44 (November 4, 2014): 15756–61. https://doi.org/10.1073/pnas.1417898111.
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  - Kir, Serkan, James P. White, Sandra Kleiner, Lawrence Kazak, Paul Cohen, Vickie E. Baracos, and Bruce M. Spiegelman. “Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia.” Nature 513, no. 7516 (September 4, 2014): 100–104. https://doi.org/10.1038/nature13528.
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  - Rao, Rajesh R., Jonathan Z. Long, James P. White, Katrin J. Svensson, Jesse Lou, Isha Lokurkar, Mark P. Jedrychowski, et al. “Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis.” Cell 157, no. 6 (June 5, 2014): 1279–91. https://doi.org/10.1016/j.cell.2014.03.065.
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  - Gomes, Ana P., Nathan L. Price, Alvin J. Y. Ling, Javid J. Moslehi, Magdalene K. Montgomery, Luis Rajman, James P. White, et al. “Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging.” Cell 155, no. 7 (December 19, 2013): 1624–38. https://doi.org/10.1016/j.cell.2013.11.037.
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  - White, J. P., M. J. Puppa, A. Narsale, and J. A. Carson. “Characterization of the male Apc^Min/+ mouse as a hypogonadism model related to cancer cachexia.” Biology Open 2, no. 12 (December 15, 2013): 1346–53. https://doi.org/10.1242/bio.20136544.
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  - Wrann, Christiane D., James P. White, John Salogiannnis, Dina Laznik-Bogoslavski, Jun Wu, Di Ma, Jiandie D. Lin, Michael E. Greenberg, and Bruce M. Spiegelman. “Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway.” Cell Metab 18, no. 5 (November 5, 2013): 649–59. https://doi.org/10.1016/j.cmet.2013.09.008.
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  - White, James P., Melissa J. Puppa, Song Gao, Shuichi Sato, Stephen L. Welle, and James A. Carson. “Muscle mTORC1 suppression by IL-6 during cancer cachexia: a role for AMPK.” Am J Physiol Endocrinol Metab 304, no. 10 (May 15, 2013): E1042–52. https://doi.org/10.1152/ajpendo.00410.2012.
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  - White, James P., Song Gao, Melissa J. Puppa, Shuichi Sato, Stephen L. Welle, and James A. Carson. “Testosterone regulation of Akt/mTORC1/FoxO3a signaling in skeletal muscle.” Mol Cell Endocrinol 365, no. 2 (January 30, 2013): 174–86. https://doi.org/10.1016/j.mce.2012.10.019.
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  - Ruas, Jorge L., James P. White, Rajesh R. Rao, Sandra Kleiner, Kevin T. Brannan, Brooke C. Harrison, Nicholas P. Greene, et al. “A PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy.” Cell 151, no. 6 (December 7, 2012): 1319–31. https://doi.org/10.1016/j.cell.2012.10.050.
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  - Gordon, Bradley S., Diana C. Delgado Díaz, James P. White, James A. Carson, and Matthew C. Kostek. “Six1 and Six1 cofactor expression is altered during early skeletal muscle overload in mice.” J Physiol Sci 62, no. 5 (September 2012): 393–401. https://doi.org/10.1007/s12576-012-0214-y.
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  - White, J. P., M. J. Puppa, S. Sato, S. Gao, R. L. Price, J. W. Baynes, M. C. Kostek, L. E. Matesic, and J. A. Carson. “IL-6 regulation on skeletal muscle mitochondrial remodeling during cancer cachexia in the Apc^Min/+ mouse.” Skeletal Muscle 2, no. 1 (July 6, 2012). https://doi.org/10.1186/2044-5040-2-14.
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  - Puppa, M. J., J. P. White, K. T. Velázquez, K. A. Baltgalvis, S. Sato, J. W. Baynes, and J. A. Carson. “The effect of exercise on IL-6-induced cachexia in the Apc^Min/+ mouse.” Journal of Cachexia, Sarcopenia and Muscle 3, no. 2 (January 1, 2012): 117–37. https://doi.org/10.1007/s13539-011-0047-1.
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  - Puppa, Melissa J., James P. White, Shuichi Sato, Mark Cairns, John W. Baynes, and James A. Carson. “Gut barrier dysfunction in the Apc(Min/+) mouse model of colon cancer cachexia.” Biochim Biophys Acta 1812, no. 12 (December 2011): 1601–6. https://doi.org/10.1016/j.bbadis.2011.08.010.
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  - Washington, T. A., J. P. White, J. M. Davis, L. B. Wilson, L. L. Lowe, S. Sato, and J. A. Carson. “Skeletal muscle mass recovery from atrophy in IL-6 knockout mice.” Acta Physiol (Oxf) 202, no. 4 (August 2011): 657–69. https://doi.org/10.1111/j.1748-1716.2011.02281.x.
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  - Greer, Beau Kjerulf, Jim P. White, Eric M. Arguello, and Emily M. Haymes. “Branched-chain amino acid supplementation lowers perceived exertion but does not affect performance in untrained males.” J Strength Cond Res 25, no. 2 (February 2011): 539–44. https://doi.org/10.1519/JSC.0b013e3181bf443a.
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  - White, James P., Kristen A. Baltgalvis, Melissa J. Puppa, Shuichi Sato, John W. Baynes, and James A. Carson. “Muscle oxidative capacity during IL-6-dependent cancer cachexia.” Am J Physiol Regul Integr Comp Physiol 300, no. 2 (February 2011): R201–11. https://doi.org/10.1152/ajpregu.00300.2010.
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  - White, James P., John W. Baynes, Stephen L. Welle, Matthew C. Kostek, Lydia E. Matesic, Shuichi Sato, and James A. Carson. “The regulation of skeletal muscle protein turnover during the progression of cancer cachexia in the Apc(Min/+) mouse.” Plos One 6, no. 9 (2011): e24650. https://doi.org/10.1371/journal.pone.0024650.
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  - Baltgalvis, Kristen A., Franklin G. Berger, Maria Marjorette O. Peña, J. Mark Davis, James P. White, and James A. Carson. “Activity level, apoptosis, and development of cachexia in Apc(Min/+) mice.” J Appl Physiol (1985) 109, no. 4 (October 2010): 1155–61. https://doi.org/10.1152/japplphysiol.00442.2010.
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  - White, J. P., J. M. Reecy, T. A. Washington, S. Sato, M. E. Le, J. M. Davis, L. B. Wilson, and J. A. Carson. “Overload-induced skeletal muscle extracellular matrix remodelling and myofibre growth in mice lacking IL-6.” Acta Physiol (Oxf) 197, no. 4 (December 2009): 321–32. https://doi.org/10.1111/j.1748-1716.2009.02029.x.
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  - White, James P., Kristen A. Baltgalvis, Shuichi Sato, L Britt Wilson, and James A. Carson. “Effect of nandrolone decanoate administration on recovery from bupivacaine-induced muscle injury.” J Appl Physiol (1985) 107, no. 5 (November 2009): 1420–30. https://doi.org/10.1152/japplphysiol.00668.2009.
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  - Baltgalvis, Kristen A., Franklin G. Berger, Maria Marjorette O. Peña, J Mark Davis, James P. White, and James A. Carson. “Muscle wasting and interleukin-6-induced atrogin-I expression in the cachectic Apc ( Min/+ ) mouse.” Pflugers Arch 457, no. 5 (March 2009): 989–1001. https://doi.org/10.1007/s00424-008-0574-6.
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  - White, J. P., J. M. Wilson, K. G. Austin, B. K. Greer, N. St. John, and L. B. Panton. “Effect of carbohydrate-protein supplement timing on acute exercise-induced muscle damage.” Journal of the International Society of Sports Nutrition 5 (February 19, 2008). https://doi.org/10.1186/1550-2783-5-5.
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  - Greer, Beau Kjerulf, John L. Woodard, Jim P. White, Eric M. Arguello, and Emily M. Haymes. “Branched-chain amino acid supplementation and indicators of muscle damage after endurance exercise.” Int J Sport Nutr Exerc Metab 17, no. 6 (December 2007): 595–607. https://doi.org/10.1123/ijsnem.17.6.595.
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- Book Sections
  - White, James P. “Control of Skeletal Muscle Cell Growth and Size Through Adhesion GPCRs.,” 234:299–308, 2016. https://doi.org/10.1007/978-3-319-41523-9_13.
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Teaching & Mentoring
Recent Courses
Scholarly, Clinical, & Service Activities
Outreach & Engaged Scholarship
- Summer Neuroscience Program Mentor. Summer Neuroscience Program. 2021 - 2022 2021 - 2022

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Education, Training, & Certifications

Previous Appointments & Affiliations

Selected Grants

Selected Publications

Academic Articles

Book Sections

Recent Courses

Outreach & Engaged Scholarship