Current Appointments & Affiliations
Assistant Professor in Medicine
·
2021 - Present
Medicine, Hematology,
Medicine
Assistant Research Professor in Cell Biology
·
2019 - Present
Cell Biology,
Basic Science Departments
Member of Duke Molecular Physiology Institute
·
2016 - Present
Duke Molecular Physiology Institute,
Institutes and Centers
Senior Fellow in the Center for the Study of Aging
·
2016 - Present
Center for the Study of Aging and Human Development,
Institutes and Centers
Member of the Duke Cancer Institute
·
2019 - Present
Duke Cancer Institute,
Institutes and Centers
Affiliate of the Duke Regeneration Center
·
2021 - Present
Duke Regeneration Center,
Basic Science Departments
Recent Publications
The CALERIE Genomic Data Resource.
Journal Article Nat Aging · February 2025 Caloric restriction (CR) slows biological aging and prolongs healthy lifespan in model organisms. Findings from the CALERIE randomized, controlled trial of long-term CR in healthy, nonobese humans broadly supports a similar pattern of effects in humans. To ... Full text Link to item CiteLiver-derived plasminogen mediates muscle stem cell expansion during caloric restriction through the plasminogen receptor Plg-RKT.
Journal Article Cell Rep · March 26, 2024 An intriguing effect of short-term caloric restriction (CR) is the expansion of certain stem cell populations, including muscle stem cells (satellite cells), which facilitate an accelerated regenerative program after injury. Here, we utilized the MetRSL274 ... Full text Link to item CiteMulti-omic rejuvenation and life span extension on exposure to youthful circulation
Journal Article Nature Aging · August 1, 2023 Heterochronic parabiosis (HPB) is known for its functional rejuvenation effects across several mouse tissues. However, its impact on biological age and long-term health is unknown. Here we performed extended (3-month) HPB, followed by a 2-month detachment ... Full text CiteRecent Grants
Fibro/Adipogenic Progenitor Metabolic Reprogramming for Age-Related Muscle Fibrosis
ResearchAdvisor · Awarded by National Institutes of Health · 2024 - 2029Endocrinology and Metabolism Training Program
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2024 - 2029Mechanisms linking the Branched-Chain alpha-Keto Acid regulatory network to the pathogenesis of NASH
ResearchCollaborator · Awarded by National Institute of Diabetes and Digestive and Kidney Diseases · 2023 - 2028View All Grants
Education, Training & Certifications
University of South Carolina, Columbia ·
2010
Ph.D.
Florida State University ·
2005
M.S.