James Patrick White Jr. | Scholars@Duke

James Patrick White Jr.
Assistant Professor in Medicine

Current Appointments & Affiliations

Assistant Professor in Medicine, Medicine, Hematology, Medicine 2016
Member of Duke Molecular Physiology Institute, Duke Molecular Physiology Institute, Duke Molecular Physiology Institute 2016
Senior Fellow in the Center for Study of Aging, Center for the Study of Aging and Human Development, Institutes and Centers 2016
Affiliate of the Regeneration Next Initiative, Regeneration Next Initiative, Institutes and Centers 2016
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2019

Contact Information

james.white@duke.edu

Background
Education, Training, & Certifications
- Postdoctoral Fellow, Harvard Medical School 2011 - 2014
- Ph.D., University of South Carolina at Columbia 2010
- M.S., Florida State University 2005
Research
Selected Grants
- The AMPK/ULK1/p27Kip1 axis regulates autophagy and cell survival in aged satellite cells awarded by National Institutes of Health 2017 - 2022
Publications & Artistic Works
Selected Publications
- Academic Articles
  - White, James P., Andrew N. Billin, Milton E. Campbell, Alan J. Russell, Kim M. Huffman, and William E. Kraus. “The AMPK/p27Kip1 Axis Regulates Autophagy/Apoptosis Decisions in Aged Skeletal Muscle Stem Cells..” Stem Cell Reports 11, no. 2 (August 2018): 425–39. https://doi.org/10.1016/j.stemcr.2018.06.014.
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  - Khandekar, Melin J., Alexander S. Banks, Dina Laznik-Bogoslavski, James P. White, Jang Hyun Choi, Lawrence Kazak, James C. Lo, et al. “Noncanonical agonist PPARγ ligands modulate the response to DNA damage and sensitize cancer cells to cytotoxic chemotherapy..” Proceedings of the National Academy of Sciences of the United States of America 115, no. 3 (January 2, 2018): 561–66. https://doi.org/10.1073/pnas.1717776115.
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  - White, J. P. “IL-6, cancer and cachexia: Metabolic dysfunction creates the perfect storm.” Translational Cancer Research 6 (March 1, 2017): S280–85. https://doi.org/10.21037/tcr.2017.03.52.
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  - Liebscher, Ines, Brian Ackley, Demet Araç, Donna M. Ariestanti, Gabriela Aust, Byoung-il Bae, Bigyan R. Bista, et al. “New functions and signaling mechanisms for the class of adhesion G protein-coupled receptors..” Annals of the New York Academy of Sciences 1333 (December 2014): 43–64. https://doi.org/10.1111/nyas.12580.
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  - White, James P., Christiane D. Wrann, Rajesh R. Rao, Sreekumaran K. Nair, Mark P. Jedrychowski, Jae-Sung You, Vicente Martínez-Redondo, et al. “G protein-coupled receptor 56 regulates mechanical overload-induced muscle hypertrophy..” Proceedings of the National Academy of Sciences of the United States of America 111, no. 44 (November 2014): 15756–61. https://doi.org/10.1073/pnas.1417898111.
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  - Kir, Serkan, James P. White, Sandra Kleiner, Lawrence Kazak, Paul Cohen, Vickie E. Baracos, and Bruce M. Spiegelman. “Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia..” Nature 513, no. 7516 (September 2014): 100–104. https://doi.org/10.1038/nature13528.
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  - Rao, Rajesh R., Jonathan Z. Long, James P. White, Katrin J. Svensson, Jesse Lou, Isha Lokurkar, Mark P. Jedrychowski, et al. “Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis..” Cell 157, no. 6 (June 2014): 1279–91. https://doi.org/10.1016/j.cell.2014.03.065.
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  - White, J. P., M. J. Puppa, A. Narsale, and J. A. Carson. “Characterization of the male Apc^Min/+ mouse as a hypogonadism model related to cancer cachexia.” Biology Open 2, no. 12 (December 15, 2013): 1346–53. https://doi.org/10.1242/bio.20136544.
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  - Gomes, Ana P., Nathan L. Price, Alvin J. Y. Ling, Javid J. Moslehi, Magdalene K. Montgomery, Luis Rajman, James P. White, et al. “Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging..” Cell 155, no. 7 (December 2013): 1624–38. https://doi.org/10.1016/j.cell.2013.11.037.
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  - Wrann, Christiane D., James P. White, John Salogiannnis, Dina Laznik-Bogoslavski, Jun Wu, Di Ma, Jiandie D. Lin, Michael E. Greenberg, and Bruce M. Spiegelman. “Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway..” Cell Metabolism 18, no. 5 (November 2013): 649–59. https://doi.org/10.1016/j.cmet.2013.09.008.
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  - White, James P., Melissa J. Puppa, Song Gao, Shuichi Sato, Stephen L. Welle, and James A. Carson. “Muscle mTORC1 suppression by IL-6 during cancer cachexia: a role for AMPK..” American Journal of Physiology. Endocrinology and Metabolism 304, no. 10 (May 2013): E1042–52. https://doi.org/10.1152/ajpendo.00410.2012.
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  - White, James P., Song Gao, Melissa J. Puppa, Shuichi Sato, Stephen L. Welle, and James A. Carson. “Testosterone regulation of Akt/mTORC1/FoxO3a signaling in skeletal muscle..” Molecular and Cellular Endocrinology 365, no. 2 (January 2013): 174–86. https://doi.org/10.1016/j.mce.2012.10.019.
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  - Ruas, Jorge L., James P. White, Rajesh R. Rao, Sandra Kleiner, Kevin T. Brannan, Brooke C. Harrison, Nicholas P. Greene, et al. “A PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy..” Cell 151, no. 6 (December 2012): 1319–31. https://doi.org/10.1016/j.cell.2012.10.050.
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  - Gordon, Bradley S., Diana C. Delgado Díaz, James P. White, James A. Carson, and Matthew C. Kostek. “Six1 and Six1 cofactor expression is altered during early skeletal muscle overload in mice..” The Journal of Physiological Sciences : Jps 62, no. 5 (September 2012): 393–401. https://doi.org/10.1007/s12576-012-0214-y.
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  - White, J. P., M. J. Puppa, S. Sato, S. Gao, R. L. Price, J. W. Baynes, M. C. Kostek, L. E. Matesic, and J. A. Carson. “IL-6 regulation on skeletal muscle mitochondrial remodeling during cancer cachexia in the Apc^Min/+ mouse.” Skeletal Muscle 2, no. 1 (July 6, 2012). https://doi.org/10.1186/2044-5040-2-14.
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  - Puppa, M. J., J. P. White, K. T. Velázquez, K. A. Baltgalvis, S. Sato, J. W. Baynes, and J. A. Carson. “The effect of exercise on IL-6-induced cachexia in the Apc^Min/+ mouse.” Journal of Cachexia, Sarcopenia and Muscle 3, no. 2 (January 1, 2012): 117–37. https://doi.org/10.1007/s13539-011-0047-1.
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  - Puppa, Melissa J., James P. White, Shuichi Sato, Mark Cairns, John W. Baynes, and James A. Carson. “Gut barrier dysfunction in the Apc(Min/+) mouse model of colon cancer cachexia..” Biochimica Et Biophysica Acta 1812, no. 12 (December 2011): 1601–6. https://doi.org/10.1016/j.bbadis.2011.08.010.
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  - Washington, T. A., J. P. White, J. M. Davis, L. B. Wilson, L. L. Lowe, S. Sato, and J. A. Carson. “Skeletal muscle mass recovery from atrophy in IL-6 knockout mice..” Acta Physiologica (Oxford, England) 202, no. 4 (August 2011): 657–69. https://doi.org/10.1111/j.1748-1716.2011.02281.x.
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  - Greer, Beau Kjerulf, Jim P. White, Eric M. Arguello, and Emily M. Haymes. “Branched-chain amino acid supplementation lowers perceived exertion but does not affect performance in untrained males..” Journal of Strength and Conditioning Research 25, no. 2 (February 2011): 539–44. https://doi.org/10.1519/jsc.0b013e3181bf443a.
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  - White, James P., Kristen A. Baltgalvis, Melissa J. Puppa, Shuichi Sato, John W. Baynes, and James A. Carson. “Muscle oxidative capacity during IL-6-dependent cancer cachexia..” American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 300, no. 2 (February 2011): R201–11. https://doi.org/10.1152/ajpregu.00300.2010.
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  - White, James P., John W. Baynes, Stephen L. Welle, Matthew C. Kostek, Lydia E. Matesic, Shuichi Sato, and James A. Carson. “The regulation of skeletal muscle protein turnover during the progression of cancer cachexia in the Apc(Min/+) mouse..” Plos One 6, no. 9 (January 2011). https://doi.org/10.1371/journal.pone.0024650.
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  - Baltgalvis, Kristen A., Franklin G. Berger, Maria Marjorette O. Peña, J. Mark Davis, James P. White, and James A. Carson. “Activity level, apoptosis, and development of cachexia in Apc(Min/+) mice..” Journal of Applied Physiology (Bethesda, Md. : 1985) 109, no. 4 (October 2010): 1155–61. https://doi.org/10.1152/japplphysiol.00442.2010.
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  - White, J. P., J. M. Reecy, T. A. Washington, S. Sato, M. E. Le, J. M. Davis, L. B. Wilson, and J. A. Carson. “Overload-induced skeletal muscle extracellular matrix remodelling and myofibre growth in mice lacking IL-6..” Acta Physiologica (Oxford, England) 197, no. 4 (December 2009): 321–32. https://doi.org/10.1111/j.1748-1716.2009.02029.x.
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  - White, James P., Kristen A. Baltgalvis, Shuichi Sato, L Britt Wilson, and James A. Carson. “Effect of nandrolone decanoate administration on recovery from bupivacaine-induced muscle injury..” Journal of Applied Physiology (Bethesda, Md. : 1985) 107, no. 5 (November 2009): 1420–30. https://doi.org/10.1152/japplphysiol.00668.2009.
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  - Baltgalvis, Kristen A., Franklin G. Berger, Maria Marjorette O. Peña, J Mark Davis, James P. White, and James A. Carson. “Muscle wasting and interleukin-6-induced atrogin-I expression in the cachectic Apc ( Min/+ ) mouse..” Pflugers Archiv : European Journal of Physiology 457, no. 5 (March 2009): 989–1001. https://doi.org/10.1007/s00424-008-0574-6.
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  - White, J. P., J. M. Wilson, K. G. Austin, B. K. Greer, N. St. John, and L. B. Panton. “Effect of carbohydrate-protein supplement timing on acute exercise-induced muscle damage.” Journal of the International Society of Sports Nutrition 5 (February 19, 2008). https://doi.org/10.1186/1550-2783-5-5.
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  - Greer, Beau Kjerulf, John L. Woodard, Jim P. White, Eric M. Arguello, and Emily M. Haymes. “Branched-chain amino acid supplementation and indicators of muscle damage after endurance exercise..” International Journal of Sport Nutrition and Exercise Metabolism 17, no. 6 (December 2007): 595–607. https://doi.org/10.1123/ijsnem.17.6.595.
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- Book Sections
  - White, J. P. “Control of Skeletal Muscle Cell Growth and Size Through Adhesion GPCRs (.” In Handbook of Experimental Pharmacology: Adhesion G Protein-Coupled Receptors, 234:299–308. Springer, 2016. https://doi.org/10.1007/978-3-319-41523-9_13.
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Education, Training, & Certifications

Selected Grants

Selected Publications

Academic Articles

Book Sections