Jamie Lynn Todd | Scholars@Duke

Jamie Lynn Todd
Assistant Professor of Medicine

I am a physician-scientist with clinical and research expertise in lung transplantation and advanced lung disease, in particular idiopathic pulmonary fibrosis (IPF). My research aims to advance scientific knowledge related to the clinical and genetic risk factors underlying the development of lung fibrosis including that occurring in chronic lung transplant rejection and diseases leading to transplant, such as IPF. I also have an interest in understanding how the airway epithelial response to injury impacts lung repair, fibrosis, and tissue immunity.

Current Appointments & Affiliations

Assistant Professor of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 2015
Member in the Duke Clinical Research Institute, Duke Clinical Research Institute, Institutes and Centers 2012

Contact Information

Box 103002, MSRB II, Durham, NC 27710
Suite 2073, MSRB II, 106 Research Drive, Durham, NC 27710
jamie.todd@duke.edu (919) 681-1353

Background
Education, Training, & Certifications
- Fellow in Pulmonary Medicine, Medicine, Duke University 2008 - 2009
- Resident, Medicine, Duke University 2005 - 2008
- M.D., University of Colorado School of Medicine 2005
Duke Appointment History
- Medical Instructor in the Department of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 2012 - 2015
- Medical Instructor in the Department of Medicine, Medicine, General Internal Medicine, Medicine 2009 - 2010
Research
Selected Grants
- CTOT Long-Term Extension Study 2019 - 2021
- Immune Profiles to Better Understand Chronic Allograft Dysfunction and Successful Long-term Clinical Outcomes after Human Lung Transplantation awarded by National Institutes of Health 2016 - 2021
- Genetics of Acute Rejection and Chronic Lung Allograft Dysfunction 2019 - 2020
- Cell-free DNA in the Blood and Lung Allograft Fluid: Understanding Association with Acute Rejection in Lung Transplant Recipients 2019 - 2020
- Lung Tissue Gene Expression Profiling in Chronic Lung Allograft Dysfunction-CTOT awarded by Mount Sinai School of Medicine 2018 - 2019
- CTOT - Cell Free DNA awarded by Mount Sinai School of Medicine 2016 - 2017
- CTOT Ancillary Studies Fund Carry Forward BAL awarded by Mount Sinai School of Medicine 2016 - 2017
- Hyaluronan in Acute Rejection and Chronic Lung Allograft Dysfunction after Human Lung Transplantation awarded by Mount Sinai School of Medicine 2016 - 2017
- CTOT Ancillary Studies Fund awarded by Mount Sinai School of Medicine 2014 - 2016
- Blood-SCAN feasibility Phase 3 2013 - 2016
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Todd, Jamie L., Joshua A. Hill, and Guang-Shing Cheng. “Herpesviruses: Silent Instigators of Lung Injury after Hematopoietic Cell Transplant..” Am J Respir Crit Care Med 200, no. 1 (July 1, 2019): 8–10. https://doi.org/10.1164/rccm.201901-0185ED.
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  - Kelly, Francine L., Kaitlyn E. Weinberg, Andrew E. Nagler, Andrew B. Nixon, Mark D. Star, Jamie L. Todd, David M. Brass, and Scott M. Palmer. “EGFR-Dependent IL8 Production by Airway Epithelial Cells After Exposure to the Food Flavoring Chemical 2,3-Butanedione..” Toxicol Sci 169, no. 2 (June 1, 2019): 534–42. https://doi.org/10.1093/toxsci/kfz066.
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  - Glanville, Allan R., Geert M. Verleden, Jamie L. Todd, Christian Benden, Fiorella Calabrese, Jens Gottlieb, Ramsey R. Hachem, et al. “Chronic lung allograft dysfunction: Definition and update of restrictive allograft syndrome-A consensus report from the Pulmonary Council of the ISHLT..” J Heart Lung Transplant 38, no. 5 (May 2019): 483–92. https://doi.org/10.1016/j.healun.2019.03.008.
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  - Todd, Jamie L., Megan L. Neely, C. A. Finlen Copeland, Courtney W. Frankel, John M. Reynolds, and Scott M. Palmer. “Prognostic significance of early pulmonary function changes after onset of chronic lung allograft dysfunction..” J Heart Lung Transplant 38, no. 2 (February 2019): 184–93. https://doi.org/10.1016/j.healun.2018.10.006.
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  - Palmer, Scott M., Laurie Snyder, Jamie L. Todd, Benjamin Soule, Rose Christian, Kevin Anstrom, Yi Luo, Robert Gagnon, and Glenn Rosen. “Randomized, Double-Blind, Placebo-Controlled, Phase 2 Trial of BMS-986020, a Lysophosphatidic Acid Receptor Antagonist for the Treatment of Idiopathic Pulmonary Fibrosis..” Chest 154, no. 5 (November 2018): 1061–69. https://doi.org/10.1016/j.chest.2018.08.1058.
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  - Messina, Julia A., Cameron R. Wolfe, Marion Hemmersbach-Miller, Carmelo Milano, Jamie L. Todd, John Reynolds, Barbara D. Alexander, Wiley A. Schell, Christina A. Cuomo, and John R. Perfect. “Genomic characterization of recurrent mold infections in thoracic transplant recipients..” Transpl Infect Dis 20, no. 5 (October 2018). https://doi.org/10.1111/tid.12935.
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  - Riley, Isaretta L., L Ebony Boulware, Jie-Lena Sun, Karen Chiswell, Loretta G. Que, Monica Kraft, Jamie L. Todd, Scott M. Palmer, and Monique L. Anderson. “Factors associated with reporting results for pulmonary clinical trials in ClinicalTrials.gov..” Clin Trials 15, no. 1 (February 2018): 87–94. https://doi.org/10.1177/1740774517740352.
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  - Petrovski, Slavé, Jamie L. Todd, Michael T. Durheim, Quanli Wang, Jason W. Chien, Fran L. Kelly, Courtney Frankel, et al. “An Exome Sequencing Study to Assess the Role of Rare Genetic Variation in Pulmonary Fibrosis..” Am J Respir Crit Care Med 196, no. 1 (July 1, 2017): 82–93. https://doi.org/10.1164/rccm.201610-2088OC.
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  - Todd, Jamie L., and Scott M. Palmer. “Danger signals in regulating the immune response to solid organ transplantation..” J Clin Invest 127, no. 7 (June 30, 2017): 2464–72. https://doi.org/10.1172/JCI90594.
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  - DerHovanessian, Ariss, Jamie L. Todd, Alice Zhang, Ning Li, Aradhna Mayalall, C Ashley Finlen Copeland, Michael Shino, et al. “Validation and Refinement of Chronic Lung Allograft Dysfunction Phenotypes in Bilateral and Single Lung Recipients..” Ann Am Thorac Soc 13, no. 5 (May 2016): 627–35. https://doi.org/10.1513/AnnalsATS.201510-719OC.
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  - Genao, Liza, Michael T. Durheim, Xiaojuan Mi, Jamie L. Todd, Heather E. Whitson, and Lesley H. Curtis. “Early and Long-term Outcomes of Older Adults after Acute Care Encounters for Chronic Obstructive Pulmonary Disease Exacerbation..” Ann Am Thorac Soc 12, no. 12 (December 2015): 1805–12. https://doi.org/10.1513/AnnalsATS.201504-250OC.
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  - Verleden, S. E., J. L. Todd, M. Sato, S. M. Palmer, T. Martinu, E. N. Pavlisko, R. Vos, et al. “Impact of CLAD Phenotype on Survival After Lung Retransplantation: A Multicenter Study..” Am J Transplant 15, no. 8 (August 2015): 2223–30. https://doi.org/10.1111/ajt.13281.
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  - Sayah, David M., Beñat Mallavia, Fengchun Liu, Guadalupe Ortiz-Muñoz, Axelle Caudrillier, Ariss DerHovanessian, David J. Ross, et al. “Neutrophil extracellular traps are pathogenic in primary graft dysfunction after lung transplantation..” Am J Respir Crit Care Med 191, no. 4 (February 15, 2015): 455–63. https://doi.org/10.1164/rccm.201406-1086OC.
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  - Foster, Matthew W., Lake D. Morrison, Jamie L. Todd, Laurie D. Snyder, J Will Thompson, Erik J. Soderblom, Kelly Plonk, et al. “Quantitative proteomics of bronchoalveolar lavage fluid in idiopathic pulmonary fibrosis..” J Proteome Res 14, no. 2 (February 6, 2015): 1238–49. https://doi.org/10.1021/pr501149m.
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  - Todd, J. L., and S. M. Palmer. “Alemtuzumab induction in lung transplantation: time to move on?.” Am J Transplant 14, no. 8 (August 2014): 1721–22. https://doi.org/10.1111/ajt.12825.
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  - Todd, Jamie L., Jason D. Christie, and Scott M. Palmer. “Update in lung transplantation 2013..” Am J Respir Crit Care Med 190, no. 1 (July 1, 2014): 19–24. https://doi.org/10.1164/rccm.201402-0384UP.
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  - Todd, Jamie L., Xingan Wang, Seichiro Sugimoto, Vanessa E. Kennedy, Helen L. Zhang, Elizabeth N. Pavlisko, Fran L. Kelly, et al. “Hyaluronan contributes to bronchiolitis obliterans syndrome and stimulates lung allograft rejection through activation of innate immunity..” Am J Respir Crit Care Med 189, no. 5 (March 1, 2014): 556–66. https://doi.org/10.1164/rccm.201308-1481OC.
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  - Todd, Jamie L., Rahil Jain, Elizabeth N. Pavlisko, C Ashley Finlen Copeland, John M. Reynolds, Laurie D. Snyder, and Scott M. Palmer. “Impact of forced vital capacity loss on survival after the onset of chronic lung allograft dysfunction..” Am J Respir Crit Care Med 189, no. 2 (January 15, 2014): 159–66. https://doi.org/10.1164/rccm.201306-1155OC.
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  - Todd, Jamie L., Kyle R. White, Karen Chiswell, Asba Tasneem, and Scott M. Palmer. “Using ClinicalTrials.gov to understand the state of clinical research in pulmonary, critical care, and sleep medicine..” Ann Am Thorac Soc 10, no. 5 (October 2013): 411–17. https://doi.org/10.1513/AnnalsATS.201305-111OC.
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  - Kennedy, V. E., J. L. Todd, and S. M. Palmer. “Bronchoalveolar lavage as a tool to predict, diagnose and understand bronchiolitis obliterans syndrome..” Am J Transplant 13, no. 3 (March 2013): 552–61. https://doi.org/10.1111/ajt.12091.
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  - Bedoya, A. D., J. L. Todd, T. Martinu, S. M. Palmer, and L. D. Snyder. “Lung Transplantation For Pulmonary Complications After Bone Marrow Transplantation.” American Journal of Respiratory and Critical Care Medicine 187 (January 1, 2013).
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  - Davis, W. A., C. A. Finlen Copeland, J. L. Todd, L. D. Snyder, J. A. Martissa, and S. M. Palmer. “Spirometrically significant acute rejection increases the risk for BOS and death after lung transplantation..” Am J Transplant 12, no. 3 (March 2012): 745–52. https://doi.org/10.1111/j.1600-6143.2011.03849.x.
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  - Todd, J. L., and S. M. Palmer. “Response.” Chest 141, no. 1 (January 1, 2012). https://doi.org/10.1378/chest.11-2258.
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  - Todd, Jamie L., David B. Goldstein, Dongliang Ge, Jason Christie, and Scott M. Palmer. “The state of genome-wide association studies in pulmonary disease: a new perspective..” Am J Respir Crit Care Med 184, no. 8 (October 15, 2011): 873–80. https://doi.org/10.1164/rccm.201106-0971PP.
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  - Todd, Jamie L., and Scott M. Palmer. “Bronchiolitis obliterans syndrome: the final frontier for lung transplantation..” Chest 140, no. 2 (August 2011): 502–8. https://doi.org/10.1378/chest.10-2838.
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  - Todd, Jamie L., and Scott M. Palmer. “Lung transplantation in advanced COPD: is it worth it?.” Semin Respir Crit Care Med 31, no. 3 (June 2010): 365–72. https://doi.org/10.1055/s-0030-1254076.
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  - Todd, Jamie L., and Victor F. Tapson. “Thrombolytic therapy for acute pulmonary embolism: a critical appraisal..” Chest 135, no. 5 (May 2009): 1321–29. https://doi.org/10.1378/chest.08-2125.
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  - Mwita, W., J. Chilongani, R. White, G. Mshana, J. Changalucha, F. Mosha, D. Ross, B. Zaba, and J. Todd. “Has the HIV epidemic in rural Mwanza, Tanzania reached a plateau?.” Tanzan J Health Res 10, no. 3 (July 2008): 117–23.
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  - Todd, J. L., J. Lakey, D. Howell, M. Reidy, and D. Zaas. “Portal hypertension and granulomatous liver disease in a lung transplant recipient due to disseminated atypical mycobacterial infection..” Am J Transplant 7, no. 5 (May 2007): 1300–1303. https://doi.org/10.1111/j.1600-6143.2007.01748.x.
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  - Ross, S. E., J. Todd, L. A. Moore, B. L. Beaty, L. Wittevrongel, and C. T. Lin. “Expectations of patients and physicians regarding patient-accessible medical records.” Journal of Medical Internet Research 7, no. 2 (April 1, 2005). https://doi.org/10.2196/jmir.7.2.e13.
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- Book Sections
  - Todd, J. L., and S. M. Palmer. “Innate immune responses and bronchiolitis obliterans syndrome.” In Bronchiolitis Obliterans Syndrome in Lung Transplantation, 147–67, 2013. https://doi.org/10.1007/978-1-4614-7636-8_8.
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- Conference Papers
  - Swaminathan, Aparna C., Megan L. Neely, Courtney W. Frankel, Fran L. Kelly, Slavé Petrovski, Michael T. Durheim, Erika Bush, et al. “Lung Transplant Outcomes in Patients With Pulmonary Fibrosis With Telomere-Related Gene Variants..” In Chest, 156:477–85, 2019. https://doi.org/10.1016/j.chest.2019.03.030.
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  - Ahmed, M., L. Levy, S. E. Hunter, K. C. Zhang, E. Huszti, K. M. Boonstra, A. T. Sage, et al. “Lung Bile Acid as Biomarker of Microaspiration and Its Relationship to Lung Inflammation.” In The Journal of Heart and Lung Transplantation, 38:S255–56. Elsevier BV, 2019. https://doi.org/10.1016/j.healun.2019.01.635.
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  - Martinu, T., A. Koutsokera, C. Benden, E. Cantu, D. Chambers, M. Cypel, J. Edelman, et al. “ISHLT Consensus on Standardization of Bronchoalveolar Lavage in Lung Transplantation.” In The Journal of Heart and Lung Transplantation, 38:S120–21. Elsevier BV, 2019. https://doi.org/10.1016/j.healun.2019.01.283.
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  - Pavlisko, E. N., M. L. Neely, H. Kopetskie, D. Hwang, C. F. Farver, A. V. Arrossi, W. D. Wallace, et al. “Occurrence and Risk Factors for Acute Lung Injury (ALI) and Organizing Pneumonia (OP) after Lung Transplant.” In The Journal of Heart and Lung Transplantation, 38:S56–57. Elsevier BV, 2019. https://doi.org/10.1016/j.healun.2019.01.124.
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  - Todd, J. L., M. L. Neely, H. Kopetskie, M. Sever, J. Kirchner, C. W. Frankel, L. D. Snyder, et al. “Acute Rejection (AR) and Lymphocytic Bronchiolitis (LB) in a Multicenter Lung Transplant Cohort.” In The Journal of Heart and Lung Transplantation, 38:S402–3. Elsevier BV, 2019. https://doi.org/10.1016/j.healun.2019.01.1025.
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  - Zhang, K. C., S. E. Hunter, E. Huszti, M. Ahmed, L. Levy, K. M. Boonstra, A. T. Sage, et al. “Effects of Nissen Fundoplication on Markers of Microaspiration and Inflammation after Lung Transplantation.” In The Journal of Heart and Lung Transplantation, 38:S73–74. Elsevier BV, 2019. https://doi.org/10.1016/j.healun.2019.01.166.
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  - Todd, J. L., M. L. Neely, C. Brinkley, F. L. Kelly, C. W. Frankel, J. Kirchner, J. A. Belperio, et al. “Hyaluronan in Acute Rejection After Lung Transplantation.” In Journal of Heart and Lung Transplantation, 37:S441–S441. ELSEVIER SCIENCE INC, 2018.
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  - Todd, J. L., V. Venkat, R. Henao, C. Brinkley, F. L. Kelly, C. W. Frankel, A. Frear, et al. “Bronchoalveolar Lavage Fluid Proteome in Chronic Lung Allograft Dysfunction.” In Journal of Heart and Lung Transplantation, 37:S204–S204. ELSEVIER SCIENCE INC, 2018.
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  - Fuller, Candace C., Craig Zinderman, Steven A. Anderson, Carolyn Balsbaugh, Nicholas Bryant, Hayley Burgess, Howard Chazin, et al. “Assessment of Transfusion-Related Acute Lung Injury after Red Blood Cell, Plasma and Platelet Administration: Initial Results in the Sentinel System.” In Pharmacoepidemiology and Drug Safety, 26:385–385. WILEY, 2017.
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  - Klement, W., J. Tikkanen, S. Juvet, J. L. Todd, S. S. Weigt, L. D. Snyder, S. Azad, et al. “Automating the Diagnosis of Potential CLAD and Its Subtypes in Lung Transplant Recipients.” In Journal of Heart and Lung Transplantation, 36:S309–S309. ELSEVIER SCIENCE INC, 2017.
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  - Todd, J. L., A. J. Mikels-Vigdal, F. L. Kelly, E. N. Pavlisko, I. Mikaelian, T. G. O’Riordan, V. C. Smith, and S. M. Palmer. “Loxl-2 Contributes To The Development Of Obliterative Bronchiolitis (ob) In Humans.” In American Journal of Respiratory and Critical Care Medicine, Vol. 195. AMER THORACIC SOC, 2017.
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  - Todd, J. L., M. W. Foster, A. Valente, C. Brinkley, H. A. Ali, J. M. Reynolds, F. L. Kelly, and S. M. Palmer. “Proteomics Of Bronchoalveolar Lavage (bal) Fluid In Bronchiolitis Obliterans Syndrome (bos).” In American Journal of Respiratory and Critical Care Medicine, Vol. 195. AMER THORACIC SOC, 2017.
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  - Durheim, M. T., D. M. Wojdyla, C. L. Green, S. Keshavjee, K. McCurry, A. O. Lidor, R. D. Davis, S. M. Palmer, and J. L. Todd. “Evaluation of an FVC-Based Definition of Restrictive Chronic Lung Allograft Dysfunction (CLAD) in a Multi-Center Cohort.” In The Journal of Heart and Lung Transplantation, 35:S117–18. Elsevier BV, 2016. https://doi.org/10.1016/j.healun.2016.01.321.
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  - Todd, J. L., C. A. Finlen Copeland, M. Neely, and S. M. Palmer. “FVC and FEV1 Decline in Chronic Lung Allograft Dysfunction (CLAD) Phenotypes.” In The Journal of Heart and Lung Transplantation, 35:S223–24. Elsevier BV, 2016. https://doi.org/10.1016/j.healun.2016.01.633.
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  - O’Brien, E. C., P. Shrader, M. T. Durheim, L. D. Snyder, J. L. Todd, V. Gamerman, K. J. Anstrom, et al. “Disease Severity And Quality Of Life In Newly Diagnosed Idiopathic Pulmonary Fibrosis Patients.” In American Journal of Respiratory and Critical Care Medicine, Vol. 193. AMER THORACIC SOC, 2016.
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  - Ali, H. A., L. D. Snyder, L. F. Diehl, J. L. Todd, and S. Aryal. “Atypical Primary Effusion Lymphoma In A Lung Transplant Recipient.” In American Journal of Respiratory and Critical Care Medicine, Vol. 191. AMER THORACIC SOC, 2015.
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  - Aryal, S., E. N. Pavlisko, and J. L. Todd. “A Case Of Acute Fibrinous And Organizing Pneumonia Associated With Development Of Anti-Hla Antibodies After Lung Transplantation.” In American Journal of Respiratory and Critical Care Medicine, Vol. 191. AMER THORACIC SOC, 2015.
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  - Chery, G. S., S. M. Palmer, L. D. Snyder, A. L. Gray, J. L. Todd, G. Harrison, and E. N. Pavlisko. “Post-Transplant Lymphoproliferative Disorder Erosion Into A Large Pulmonary Artery With Death Secondary To Hemorrhagic Shock.” In American Journal of Respiratory and Critical Care Medicine, Vol. 191. AMER THORACIC SOC, 2015.
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  - Chery, G. S., S. M. Palmer, L. D. Snyder, J. L. Todd, and C. Wolfe. “Brincidofovir In Progressive Multifocal Leukoencephalopathy After Lung Transplant.” In American Journal of Respiratory and Critical Care Medicine, Vol. 191. AMER THORACIC SOC, 2015.
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  - Copeland, CA Finlen, J. A. Martissa, C. W. Frankel, E. C. Benedetti, E. Callahan, D. Ross, S. M. Palmer, et al. “A Prospective Multicenter Assessment Of Aztreonam Lysine For Inhalation In The Treatment Of Lung Transplant Recipients With Chronic Lung Allograft Dysfunction.” In American Journal of Respiratory and Critical Care Medicine, Vol. 191. AMER THORACIC SOC, 2015.
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  - Todd, J. L., F. L. Kelly, D. M. Brass, V. E. Kennedy, E. N. Pavlisko, and S. M. Palmer. “Increased Amphiregulin Expression Is Associated With Chronic Allograft Dysfunction After Lung Transplantation.” In American Journal of Respiratory and Critical Care Medicine, Vol. 191. AMER THORACIC SOC, 2015.
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  - Todd, J. L., T. J. Urban, C. A. Finlen Copeland, F. L. Kelly, D. B. Goldstein, and S. M. Palmer. “Whole Exome Sequencing: A Novel Strategy to Understand Chronic Lung Allograft Dysfunction (CLAD).” In The Journal of Heart and Lung Transplantation, 33:S140–S140. Elsevier BV, 2014. https://doi.org/10.1016/j.healun.2014.01.377.
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  - Todd, J. L., V. E. Kennedy, E. N. Pavlisko, H. L. Zhang, F. L. Kelly, and S. M. Palmer. “Elevated Hyaluronan Is Associated with Bronchiolitis Obliterans Syndrome.” In The Journal of Heart and Lung Transplantation, 33:S106–7. Elsevier BV, 2014. https://doi.org/10.1016/j.healun.2014.01.319.
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  - Todd, J. L., R. Jain, E. N. Pavlisko, C Finlen Copeland, L. D. Snyder, and S. M. Palmer. “Restrictive Spirometry At Bronchiolitis Obliterans Syndrome Onset Predicts Worse Survival.” In American Journal of Respiratory and Critical Care Medicine, Vol. 187. AMER THORACIC SOC, 2013.
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Education, Training, & Certifications

Duke Appointment History

Selected Grants

Selected Publications

Academic Articles

Book Sections

Conference Papers