Jane Blackmer

Journal article Genetics · October 8, 2025 Amplified centrosome number causes genomic instability, most severely through division into >2 aneuploid daughter cells (multipolar mitosis). Several mechanisms that suppress multipolar division have been uncovered, yet mechanisms that favor viable multipo ... Full text Link to item Cite

Anatomy Drawing: Dissecting the Impact of Art in Medicine.

Journal article Med Sci Educ · April 2025 INTRODUCTION: Many studies have examined the role of medical humanities in processing overall academic and emotional experiences, but few have studied the impact of visual art on human body dissection reflection. At the Duke University School of Medicine, ... Full text Link to item Cite

Progressive transformation of the HIV-1 reservoir cell profile over two decades of antiviral therapy.

Journal article Cell host & microbe · January 2023 HIV-1 establishes a life-long reservoir of virally infected cells which cannot be eliminated by antiretroviral therapy (ART). Here, we demonstrate a markedly altered viral reservoir profile of long-term ART-treated individuals, characterized by large clone ... Full text Cite

Parallel analysis of transcription, integration, and sequence of single HIV-1 proviruses.

Journal article Cell · January 2022 HIV-1-infected cells that persist despite antiretroviral therapy (ART) are frequently considered "transcriptionally silent," but active viral gene expression may occur in some cells, challenging the concept of viral latency. Applying an assay for profiling ... Full text Cite

Distinct viral reservoirs in individuals with spontaneous control of HIV-1.

Journal article Nature · September 2020 Sustained, drug-free control of HIV-1 replication is naturally achieved in less than 0.5% of infected individuals (here termed 'elite controllers'), despite the presence of a replication-competent viral reservoir1. Inducing such an ability to sp ... Full text Cite

Blood and Lymph Node Dissemination of Clonal Genome-Intact Human Immunodeficiency Virus 1 DNA Sequences During Suppressive Antiretroviral Therapy.

Journal article The Journal of infectious diseases · July 2020 The majority of cells with latent human immunodeficiency virus 1 infection are located in lymphoid tissues that are difficult to access. In the current study, we used single-genome near-full-length proviral sequencing to evaluate intact and defective provi ... Full text Cite

Immune-profiling of ZIKV-infected patients identifies a distinct function of plasmacytoid dendritic cells for immune cross-regulation.

Journal article Nature communications · May 2020 Zika virus (ZIKV) is a mosquito-borne pathogen with increasing public health significance. To characterize immune responses to ZIKV, here we examine transcriptional signatures of CD4 T, CD8 T, B, and NK cells, monocytes, myeloid dendritic cells (mDCs), and ... Full text Cite