Janet Knight Horton

Journal article Breast J · September 2012 Featured Publication Benign papillary lesions of the breast include papilloma and papillomatosis. A retrospective analysis of patients with a papillary breast lesion diagnosed between October 1992 and December 2009 was performed. Patients were excluded if they had a previous o ... Full text Link to item Cite

Comparison of 3D conformal breast radiation treatment plans using the anisotropic analytical algorithm and pencil beam convolution algorithm.

Journal article Radiother Oncol · May 2012 Featured Publication PURPOSE: To investigate (1) dosimetric differences between plans calculated using the anisotropic analytical algorithm (AAA) and pencil beam convolution (PBC) algorithm, (2) the plan quality achieved using AAA compared to PBC based on dosimetric parameters ... Full text Link to item Cite

Carbonic anhydrase IX is a predictive marker of doxorubicin resistance in early-stage breast cancer independent of HER2 and TOP2A amplification.

Journal article Br J Cancer · February 28, 2012 Featured Publication BACKGROUND: In early-stage breast cancer, adjuvant chemotherapy is associated with significant systemic toxicity with only a modest survival benefit. Therefore, there is considerable interest in identifying predictive markers of response to therapy. Doxoru ... Full text Link to item Cite

Phase I study and biomarker analysis of lapatinib and concurrent radiation for locally advanced breast cancer.

Journal article Oncologist · 2012 Featured Publication PURPOSE: This phase I study assessed the toxicity and safety of combining daily lapatinib with radiation therapy. Sequential tumor biopsies were obtained to evaluate changes in biomarkers, such as epidermal growth factor receptor (EGFR) and human EGFR-2 (H ... Full text Link to item Cite

Preoperative single fraction partial breast radiotherapy for early-stage breast cancer.

Journal article Int J Radiat Oncol Biol Phys · January 1, 2012 Featured Publication PURPOSE: Several recent series evaluating external beam accelerated partial breast irradiation (PBI) have reported adverse cosmetic outcomes, possibly related to large volumes of normal tissue receiving near-prescription doses. We hypothesized that deliver ... Full text Link to item Cite

A comparison of clinical and dosimetric outcomes in patients receiving partial breast irradiation with photon-only versus mixed photon/electron treatment plans.

Journal article Med Dosim · 2011 Featured Publication Several series evaluating external-beam partial breast irradiation (PBI) have linked negative cosmetic outcomes to large normal tissue treatment volumes. We compared patients treated with PBI whose treatment plans included only photons to those whose plans ... Full text Link to item Cite

Impact of volumetric modulated arc therapy technique on treatment with partial breast irradiation.

Journal article Int J Radiat Oncol Biol Phys · September 1, 2010 Featured Publication PURPOSE: To investigate the technical feasibility of volumetric modulated arc therapy (V-MAT) in the delivery of partial breast irradiation (PBI). METHODS AND MATERIALS: V-MAT and the standard, three-dimensional conformal radiotherapy (3D-CRT), were compar ... Full text Link to item Cite

Radiosensitization of chemotherapy-refractory, locally advanced or locally recurrent breast cancer with trastuzumab: a phase II trial.

Journal article Int J Radiat Oncol Biol Phys · March 15, 2010 Featured Publication PURPOSE: Trastuzumab (Herceptin), an anti-human epidermal growth factor receptor 2 (HER2) antibody, has been shown to be an effective radiosensitizer in preclinical studies. The present Phase II trial evaluated trastuzumab plus radiotherapy in patients wit ... Full text Link to item Cite

Accelerated partial breast irradiation: caution and concern from an ASTRO task force.

Journal article Int J Radiat Oncol Biol Phys · July 15, 2009 Featured Publication Full text Link to item Cite

Recurrence after mastectomy for ductal carcinoma in situ.

Journal article Am Surg · July 2009 Featured Publication Mastectomy has long been a standard option for patients with ductal carcinoma in situ (DCIS). It is preferentially chosen by some women and may be suggested for individuals with recurrent, multifocal, or multicentric disease. We chose to evaluate our recen ... Link to item Cite

Trends in the outcomes for patients with limited stage small cell lung cancer: An analysis of the Surveillance, Epidemiology, and End Results database.

Journal article Lung Cancer · May 2009 Featured Publication We used the Surveillance, Epidemiology, and End Results (SEER) database to examine the outcomes of patients with limited stage small cell lung cancer (LS-SCLC) over time and to determine if any trends were present with respect to the publication of signifi ... Full text Link to item Cite

Comparison of three concomitant boost techniques for early-stage breast cancer.

Journal article Int J Radiat Oncol Biol Phys · January 1, 2006 Featured Publication PURPOSE: Whole breast radiotherapy (RT) followed by a tumor bed boost typically spans 5-6 weeks of treatment. Interest is growing in RT regimens, such as concomitant boost, that decrease overall treatment time, lessening the time/cost burden to patients an ... Full text Link to item Cite

Staging of colorectal cancer: past, present, and future.

Journal article Clin Colorectal Cancer · January 2005 Featured Publication Since the inception of staging for colorectal cancer (CRC), anatomic extent of disease has provided a solid foundation for predicting prognosis and guiding treatment in patients with CRC. However, the rapid advances in biologic and genetic technology have ... Full text Link to item Cite

Hospice. Care when there is no cure.

Journal article N C Med J · 2001 Featured Publication Link to item Cite