Scholars@Duke
Janet Knight Horton

Janet Knight Horton

Adjunct Associate Professor in the Department of Radiation Oncology
Radiation Oncology
Department of Radiation Oncolo, Box 3085, Durham, NC 27710
201 Trent Drive, 05151A Morris Building, Box 3085, Durham, NC 27710

Scholarly Works - Journal articles

Pharmacokinetic Drug-Drug Interaction Studies Between Trilaciclib and Midazolam, Metformin, Rifampin, Itraconazole, and Topotecan in Healthy Volunteers and Patients with Extensive-Stage Small-Cell Lung Cancer.

Journal article Clin Drug Investig · August 2022 BACKGROUND AND OBJECTIVE: Trilaciclib is a cyclin-dependent kinase 4/6 inhibitor indicated to decrease the incidence of chemotherapy-induced myelosuppression in patients with extensive-stage small-cell lung cancer. Trilaciclib is a substrate and time-depen ... Full text Link to item Cite

Trilaciclib Prior to Chemotherapy in Patients with Metastatic Triple-Negative Breast Cancer: Final Efficacy and Subgroup Analysis from a Randomized Phase II Study.

Journal article Clin Cancer Res · February 15, 2022 PURPOSE: We report final antitumor efficacy results from a phase II study of trilaciclib, an intravenous cyclin-dependent kinase 4/6 (CDK4/6) inhibitor, administered prior to gemcitabine plus carboplatin (GCb) in patients with metastatic triple-negative br ... Full text Link to item Cite

Exploratory composite endpoint demonstrates benefit of trilaciclib across multiple clinically meaningful components of myeloprotection in patients with small cell lung cancer.

Journal article Int J Cancer · October 1, 2021 Chemotherapy-induced myelosuppression is an acute, dose-limiting toxicity of chemotherapy regimens used in the treatment of extensive-stage small cell lung cancer (ES-SCLC). Trilaciclib protects haematopoietic stem and progenitor cells from chemotherapy-in ... Full text Link to item Cite

Management of the Axilla in Early-Stage Breast Cancer: Ontario Health (Cancer Care Ontario) and ASCO Guideline.

Journal article J Clin Oncol · September 20, 2021 PURPOSE: To provide recommendations on the best strategies for the management and on the best timing and treatment (surgical and radiotherapeutic) of the axilla for patients with early-stage breast cancer. METHODS: Ontario Health (Cancer Care Ontario) and ... Full text Link to item Cite

Evaluation of Safety of Stereotactic Body Radiotherapy for the Treatment of Patients With Multiple Metastases: Findings From the NRG-BR001 Phase 1 Trial.

Journal article JAMA Oncol · June 1, 2021 IMPORTANCE: Stereotactic body radiotherapy (SBRT) for oligometastases is hypothesized to improve survival and is increasingly used. Little evidence supports its safe use to treat patients with multiple metastases. OBJECTIVE: To establish safety of SBRT dos ... Full text Link to item Cite

First, Do No Harm.

Journal article Int J Radiat Oncol Biol Phys · February 1, 2019 Full text Link to item Cite

Single dose partial breast irradiation using an MRI linear accelerator in the supine and prone treatment position.

Journal article Clin Transl Radiat Oncol · January 2019 BACKGROUND: In selected patients with early-stage and low-risk breast cancer, an MRI-linac based treatment might enable a radiosurgical, non-invasive alternative for current standard breast conserving therapy. AIM: To investigate whether single dose accele ... Full text Link to item Cite

Lessons Learned From Hurricane Maria in Puerto Rico: Practical Measures to Mitigate the Impact of a Catastrophic Natural Disaster on Radiation Oncology Patients.

Journal article Pract Radiat Oncol · 2019 PURPOSE: Although the wind, rain, and flooding of Hurricane Maria in Puerto Rico abated shortly after its landfall on September 20, 2017, the disruption of the electrical, communications, transportation, and medical infrastructure of the island was unprece ... Full text Link to item Cite

Automatic Planning of Whole Breast Radiation Therapy Using Machine Learning Models.

Journal article Front Oncol · 2019 Purpose: To develop an automatic treatment planning system for whole breast radiation therapy (WBRT) based on two intensity-modulated tangential fields, enabling near-real-time planning. Methods and Materials: A total of 40 WBRT plans from a single institu ... Full text Open Access Link to item Cite

Findings on Surveillance Imaging After Preoperative Partial Breast Irradiation for Early Stage Breast Cancer.

Journal article Int J Radiat Oncol Biol Phys · November 15, 2018 PURPOSE: To evaluate the mammographic sequelae of preoperative accelerated partial breast irradiation (APBI) delivered via either stereotactic radiosurgery or a conventionally fractionated regimen. METHODS AND MATERIALS: This multicenter, retrospective stu ... Full text Link to item Cite

A Phase II Study of Pembrolizumab in EGFR-Mutant, PD-L1+, Tyrosine Kinase Inhibitor Naïve Patients With Advanced NSCLC.

Journal article J Thorac Oncol · August 2018 BACKGROUND: Despite the significant antitumor activity of pembrolizumab in NSCLC, clinical benefit has been less frequently observed in patients whose tumors harbor EGFR mutations compared to EGFR wild-type patients. Our single-center experience on the KEY ... Full text Link to item Cite

Concurrent Veliparib With Chest Wall and Nodal Radiotherapy in Patients With Inflammatory or Locoregionally Recurrent Breast Cancer: The TBCRC 024 Phase I Multicenter Study.

Journal article J Clin Oncol · May 1, 2018 Purpose Locoregional control for inflammatory breast cancers and chest wall recurrences is suboptimal, which has motivated interest in radiosensitization to intensify therapy. Preclinical studies have suggested a favorable therapeutic index when poly (ADP- ... Full text Link to item Cite

Blocking Interleukin (IL)4- and IL13-Mediated Phosphorylation of STAT6 (Tyr641) Decreases M2 Polarization of Macrophages and Protects Against Macrophage-Mediated Radioresistance of Inflammatory Breast Cancer.

Journal article Int J Radiat Oncol Biol Phys · March 15, 2018 PURPOSE: To determine the role of macrophage polarization on the response of inflammatory breast cancer (IBC) cells to radiation and whether modulation of macrophage plasticity can alter radiation response. METHODS AND MATERIALS: The human THP-1 monocyte c ... Full text Link to item Cite

Breast Cancer Biology: Clinical Implications for Breast Radiation Therapy.

Journal article Int J Radiat Oncol Biol Phys · January 1, 2018 Historically, prognosis and treatment decision making for breast cancer patients have been dictated by the anatomic extent of tumor spread. However, in recent years, "breast cancer" has proven to be a collection of unique phenotypes with distinct prognoses ... Full text Link to item Cite

Treatment constraints for single dose external beam preoperative partial breast irradiation in early-stage breast cancer.

Journal article Clin Transl Radiat Oncol · October 2017 BACKGROUND: Following breast-conserving surgery and post-operative 3D-conformal accelerated partial breast irradiation (APBI), suboptimal cosmetic results have been reported. Preoperative radiation delivery to the intact tumor enables better target visuali ... Full text Link to item Cite

Subtype-Specific Radiation Response and Therapeutic Effect of FAS Death Receptor Modulation in Human Breast Cancer.

Journal article Radiat Res · August 2017 Breast cancer is the most common malignancy diagnosed among women and represents a heterogeneous group of subtypes. Radiation therapy is a critical component of treatment for breast cancer patients. However, little is known about radiation response among t ... Full text Link to item Cite

Postmastectomy Conundrum.

Journal article Int J Radiat Oncol Biol Phys · August 1, 2017 Full text Link to item Cite

Cost Implications of an Evidence-Based Approach to Radiation Treatment After Lumpectomy for Early-Stage Breast Cancer.

Journal article J Oncol Pract · April 2017 INTRODUCTION: Breast cancer treatment costs are rising, and identification of high-value oncology treatment strategies is increasingly needed. We sought to determine the potential cost savings associated with an evidence-based radiation treatment (RT) appr ... Full text Link to item Cite

Society of Surgical Oncology-American Society for Radiation Oncology-American Society of Clinical Oncology Consensus Guideline on Margins for Breast-Conserving Surgery With Whole-Breast Irradiation in Ductal Carcinoma In Situ.

Journal article J Clin Oncol · November 20, 2016 Background Controversy exists regarding the optimal negative margin width for ductal carcinoma in situ (DCIS) treated with breast-conserving surgery and whole-breast irradiation (WBRT). Methods A multidisciplinary consensus panel used a meta-analysis of ma ... Full text Link to item Cite

Society of Surgical Oncology-American Society for Radiation Oncology-American Society of Clinical Oncology Consensus Guideline on Margins for Breast-Conserving Surgery with Whole-Breast Irradiation in Ductal Carcinoma In Situ.

Journal article Ann Surg Oncol · November 2016 PURPOSE: Controversy exists regarding the optimal negative margin width for ductal carcinoma in situ (DCIS) treated with breast-conserving surgery and whole-breast irradiation. METHODS: A multidisciplinary consensus panel used a meta-analysis of margin wid ... Full text Link to item Cite

Assessment of Treatment Response With Diffusion-Weighted MRI and Dynamic Contrast-Enhanced MRI in Patients With Early-Stage Breast Cancer Treated With Single-Dose Preoperative Radiotherapy: Initial Results.

Journal article Technol Cancer Res Treat · October 2016 Single-dose preoperative stereotactic body radiotherapy is a novel radiotherapy technique for the early-stage breast cancer, and the treatment response pattern of this technique needs to be investigated on a quantitative basis. In this work, dynamic contra ... Full text Link to item Cite

Society of Surgical Oncology-American Society for Radiation Oncology-American Society of Clinical Oncology Consensus Guideline on Margins for Breast-Conserving Surgery With Whole-Breast Irradiation in Ductal Carcinoma in Situ.

Journal article Pract Radiat Oncol · 2016 PURPOSE: Controversy exists regarding the optimal negative margin width for ductal carcinoma in situ (DCIS) treated with breast-conserving surgery and whole-breast irradiation. METHODS AND MATERIALS: A multidisciplinary consensus panel used a meta-analysis ... Full text Link to item Cite

Whose Disease Will Recur After Mastectomy for Early Stage, Node-Negative Breast Cancer? A Systematic Review.

Journal article Clin Breast Cancer · December 2015 Effective local control is associated with improved overall survival, particularly for women with early-stage cancers. No other local therapy is typically offered to women with T1-2 N0 breast cancer after mastectomy, although in select women the 5-year loc ... Full text Link to item Cite

FAS Death Receptor: A Breast Cancer Subtype-Specific Radiation Response Biomarker and Potential Therapeutic Target.

Journal article Radiat Res · November 2015 Although a standardized approach to radiotherapy has been used to treat breast cancer, regardless of subtype (e.g., luminal, basal), recent clinical data suggest that radiation response may vary significantly among subtypes. We hypothesized that this clini ... Full text Link to item Cite

Prognostic significance of differential expression of angiogenic genes in women with high-grade serous ovarian carcinoma.

Journal article Gynecol Oncol · October 2015 OBJECTIVES: To identify angiogenic biomarkers associated with tumor angiogenesis and clinical outcome in high-grade serous ovarian cancer (HGSC). METHODS: 51 HGSC samples were analyzed using Affymetrix HG-U133A microarray. Microvessel density (MVD) counts ... Full text Link to item Cite

Preoperative Single-Fraction Partial Breast Radiation Therapy: A Novel Phase 1, Dose-Escalation Protocol With Radiation Response Biomarkers.

Journal article Int J Radiat Oncol Biol Phys · July 15, 2015 PURPOSE: Women with biologically favorable early-stage breast cancer are increasingly treated with accelerated partial breast radiation (PBI). However, treatment-related morbidities have been linked to the large postoperative treatment volumes required for ... Full text Link to item Cite

Genomic profiling in locally advanced and inflammatory breast cancer and its link to DCE-MRI and overall survival.

Journal article Int J Hyperthermia · June 2015 PURPOSE: We have previously reported that dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) perfusion patterns obtained from locally advanced breast cancer (LABC) patients prior to neoadjuvant therapy predicted pathologic clinical response. Ge ... Full text Link to item Cite

Dosimetric comparison of preoperative single-fraction partial breast radiotherapy techniques: 3D CRT, noncoplanar IMRT, coplanar IMRT, and VMAT.

Journal article J Appl Clin Med Phys · January 8, 2015 The purpose of this study was to compare dosimetric parameters of treatment plans among four techniques for preoperative single-fraction partial breast radiotherapy in order to select an optimal treatment technique. The techniques evaluated were noncoplana ... Full text Link to item Cite

Surgical patterns of care in patients with invasive breast cancer treated with neoadjuvant systemic therapy and breast magnetic resonance imaging: results of a secondary analysis of TBCRC 017.

Journal article Ann Surg Oncol · January 2015 BACKGROUND: Neoadjuvant chemotherapy (NCT) downstages advanced primary tumors, with magnetic resonance imaging (MRI) being the most sensitive imaging predictor of response. However, the impact of MRI evaluation on surgical treatment decisions in the neoadj ... Full text Link to item Cite

Dosimetric comparison of preoperative single-fraction partial breast radiotherapy techniques: 3D CRT, noncoplanar IMRT, coplanar IMRT, and VMAT

Journal article Journal of Applied Clinical Medical Physics · January 1, 2015 The purpose of this study was to compare dosimetric parameters of treatment plans among four techniques for preoperative single-fraction partial breast radiotherapy in order to select an optimal treatment technique. The techniques evaluated were noncoplana ... Cite

Exercise behavior and patient-reported outcomes in women with early breast cancer receiving locoregional radiation therapy.

Journal article Pract Radiat Oncol · 2015 PURPOSE: Radiation therapy is associated with acute treatment-related complications that can lead to decreased quality of life (QOL). Exercise has been shown in other cancer treatment settings to improve negative outcomes. We conducted a prospective pilot ... Full text Link to item Cite

A phase 1 trial of preoperative partial breast radiation therapy: Patient selection, target delineation, and dose delivery.

Journal article Pract Radiat Oncol · 2015 PURPOSE: Diffusion of accelerated partial breast irradiation into clinical practice is limited by the need for specialized equipment and training. The accessible external beam technique yields unacceptable complication rates, likely from large postoperativ ... Full text Link to item Cite

Oncology scandquality of life and patient perspectives during breast radiation therapy

Journal article International Journal of Radiation Oncology Biology Physics · January 1, 2015 Full text Cite

Society of Surgical Oncology-American Society for Radiation Oncology consensus guideline on margins for breast-conserving surgery with whole-breast irradiation in stages I and II invasive breast cancer.

Journal article J Clin Oncol · May 10, 2014 PURPOSE: Controversy exists regarding the optimal margin width in breast-conserving surgery for invasive breast cancer. METHODS: A multidisciplinary consensus panel used a meta-analysis of margin width and ipsilateral breast tumor recurrence (IBTR) from a ... Full text Link to item Cite

Society of Surgical Oncology-American Society for Radiation Oncology consensus guideline on margins for breast-conserving surgery with whole-breast irradiation in stages I and II invasive breast cancer.

Journal article Int J Radiat Oncol Biol Phys · March 1, 2014 PURPOSE: To convene a multidisciplinary panel of breast experts to examine the relationship between margin width and ipsilateral breast tumor recurrence (IBTR) and develop a guideline for defining adequate margins in the setting of breast conserving surger ... Full text Link to item Cite

Society of Surgical Oncology-American Society for Radiation Oncology consensus guideline on margins for breast-conserving surgery with whole-breast irradiation in stages I and II invasive breast cancer.

Journal article Ann Surg Oncol · March 2014 PURPOSE: Controversy exists regarding the optimal margin width in breast-conserving surgery for invasive breast cancer. METHODS: A multidisciplinary consensus panel used a meta-analysis of margin width and ipsilateral breast tumor recurrence (IBTR) from a ... Full text Link to item Cite

Dosimetric comparison of 3D conformal, IMRT, and V-MAT techniques for accelerated partial-breast irradiation (APBI).

Journal article Med Dosim · 2014 The purpose is to dosimetrically compare the following 3 delivery techniques: 3-dimensional conformal radiation therapy (3D-CRT), intensity-modulated arc therapy (IMRT), and volumetric-modulated arc therapy (V-MAT) in the treatment of accelerated partial-b ... Full text Link to item Cite

Radiotherapy after mastectomy.

Journal article Surg Oncol Clin N Am · July 2013 Classic randomized trials documented the benefit of postmastectomy radiotherapy in women with node-positive or locally advanced breast cancer. Modern advances in surgical therapy, systemic therapy, and radiotherapy, however, along with an improved understa ... Full text Link to item Cite

Magnetic resonance imaging as a predictor of pathologic response in patients treated with neoadjuvant systemic treatment for operable breast cancer. Translational Breast Cancer Research Consortium trial 017.

Journal article Cancer · May 15, 2013 BACKGROUND: Increased pathologic complete response (pCR) rates observed with neoadjuvant chemotherapy (NCT) for some subsets of patients with invasive breast cancer have prompted interest in whether patients who achieved a pCR can be identified preoperativ ... Full text Link to item Cite

Multidisciplinary care of patients with early-stage breast cancer.

Journal article Surg Oncol Clin N Am · April 2013 There is a compelling need for close coordination and integration of multiple specialties in the management of patients with early-stage breast cancer. Optimal patient care and outcomes depend on the sequential and often simultaneous participation and dial ... Full text Link to item Cite

Oncology scan - Breast cancers

Journal article International Journal of Radiation Oncology Biology Physics · April 1, 2013 Full text Cite

Treatment planning technique in patients receiving postmastectomy radiation therapy.

Journal article Pract Radiat Oncol · 2013 Many of the technical subtleties involved in postmastectomy radiation treatment planning will never be addressed in a robust clinical trial setting. However, these issues are faced daily by practicing radiation oncologists with little to guide them in the ... Full text Link to item Cite

Oncology scan - breast cancer.

Journal article International journal of radiation oncology, biology, physics · September 2012 Full text Cite

Risk of invasive breast cancer and ductal carcinoma in situ in women with atypical papillary lesions of the breast.

Journal article Breast J · September 2012 Featured Publication Benign papillary lesions of the breast include papilloma and papillomatosis. A retrospective analysis of patients with a papillary breast lesion diagnosed between October 1992 and December 2009 was performed. Patients were excluded if they had a previous o ... Full text Link to item Cite

Comparison of 3D conformal breast radiation treatment plans using the anisotropic analytical algorithm and pencil beam convolution algorithm.

Journal article Radiother Oncol · May 2012 Featured Publication PURPOSE: To investigate (1) dosimetric differences between plans calculated using the anisotropic analytical algorithm (AAA) and pencil beam convolution (PBC) algorithm, (2) the plan quality achieved using AAA compared to PBC based on dosimetric parameters ... Full text Link to item Cite

Carbonic anhydrase IX is a predictive marker of doxorubicin resistance in early-stage breast cancer independent of HER2 and TOP2A amplification.

Journal article Br J Cancer · February 28, 2012 Featured Publication BACKGROUND: In early-stage breast cancer, adjuvant chemotherapy is associated with significant systemic toxicity with only a modest survival benefit. Therefore, there is considerable interest in identifying predictive markers of response to therapy. Doxoru ... Full text Link to item Cite

Phase I study and biomarker analysis of lapatinib and concurrent radiation for locally advanced breast cancer.

Journal article Oncologist · 2012 Featured Publication PURPOSE: This phase I study assessed the toxicity and safety of combining daily lapatinib with radiation therapy. Sequential tumor biopsies were obtained to evaluate changes in biomarkers, such as epidermal growth factor receptor (EGFR) and human EGFR-2 (H ... Full text Link to item Cite

Preoperative single fraction partial breast radiotherapy for early-stage breast cancer.

Journal article Int J Radiat Oncol Biol Phys · January 1, 2012 Featured Publication PURPOSE: Several recent series evaluating external beam accelerated partial breast irradiation (PBI) have reported adverse cosmetic outcomes, possibly related to large volumes of normal tissue receiving near-prescription doses. We hypothesized that deliver ... Full text Link to item Cite

Protein Pathway Activation after Ionizing Radiation in Luminal and Basal Breast Cancer Cell Lines

Journal article International Journal of Radiation Oncology*Biology*Physics · October 2011 Full text Cite

Age-related disparities in the use of radiotherapy for treatment of localized soft tissue sarcoma.

Journal article Cancer · September 1, 2011 BACKGROUND: Many elderly patients with cancer experience increased cancer-related morbidity and mortality compared with younger patients. In soft tissue sarcoma, adjuvant radiotherapy is an integral part of definitive therapy for limb preservation. The aut ... Full text Link to item Cite

In response to Drs. Kim and Shaitelman

Journal article International Journal of Radiation Oncology Biology Physics · May 1, 2011 Full text Cite

A comparison of clinical and dosimetric outcomes in patients receiving partial breast irradiation with photon-only versus mixed photon/electron treatment plans.

Journal article Med Dosim · 2011 Featured Publication Several series evaluating external-beam partial breast irradiation (PBI) have linked negative cosmetic outcomes to large normal tissue treatment volumes. We compared patients treated with PBI whose treatment plans included only photons to those whose plans ... Full text Link to item Cite

Impact of volumetric modulated arc therapy technique on treatment with partial breast irradiation.

Journal article Int J Radiat Oncol Biol Phys · September 1, 2010 Featured Publication PURPOSE: To investigate the technical feasibility of volumetric modulated arc therapy (V-MAT) in the delivery of partial breast irradiation (PBI). METHODS AND MATERIALS: V-MAT and the standard, three-dimensional conformal radiotherapy (3D-CRT), were compar ... Full text Link to item Cite

Radiosensitization of chemotherapy-refractory, locally advanced or locally recurrent breast cancer with trastuzumab: a phase II trial.

Journal article Int J Radiat Oncol Biol Phys · March 15, 2010 Featured Publication PURPOSE: Trastuzumab (Herceptin), an anti-human epidermal growth factor receptor 2 (HER2) antibody, has been shown to be an effective radiosensitizer in preclinical studies. The present Phase II trial evaluated trastuzumab plus radiotherapy in patients wit ... Full text Link to item Cite

Accelerated partial breast irradiation: caution and concern from an ASTRO task force.

Journal article Int J Radiat Oncol Biol Phys · July 15, 2009 Featured Publication Full text Link to item Cite

Recurrence after mastectomy for ductal carcinoma in situ.

Journal article Am Surg · July 2009 Featured Publication Mastectomy has long been a standard option for patients with ductal carcinoma in situ (DCIS). It is preferentially chosen by some women and may be suggested for individuals with recurrent, multifocal, or multicentric disease. We chose to evaluate our recen ... Link to item Cite

Trends in the outcomes for patients with limited stage small cell lung cancer: An analysis of the Surveillance, Epidemiology, and End Results database.

Journal article Lung Cancer · May 2009 Featured Publication We used the Surveillance, Epidemiology, and End Results (SEER) database to examine the outcomes of patients with limited stage small cell lung cancer (LS-SCLC) over time and to determine if any trends were present with respect to the publication of signifi ... Full text Link to item Cite

Comparison of three concomitant boost techniques for early-stage breast cancer.

Journal article Int J Radiat Oncol Biol Phys · January 1, 2006 Featured Publication PURPOSE: Whole breast radiotherapy (RT) followed by a tumor bed boost typically spans 5-6 weeks of treatment. Interest is growing in RT regimens, such as concomitant boost, that decrease overall treatment time, lessening the time/cost burden to patients an ... Full text Link to item Cite

Staging of colorectal cancer: past, present, and future.

Journal article Clin Colorectal Cancer · January 2005 Featured Publication Since the inception of staging for colorectal cancer (CRC), anatomic extent of disease has provided a solid foundation for predicting prognosis and guiding treatment in patients with CRC. However, the rapid advances in biologic and genetic technology have ... Full text Link to item Cite

Hospice. Care when there is no cure.

Journal article N C Med J · 2001 Featured Publication Link to item Cite