Scholars@Duke
Jared Rex Robbins

Jared Rex Robbins

Professor of Radiation Oncology
Radiation Oncology

Scholarly Works

Simultaneous Versus Sequential IMRT Boost in the Era of Treatment De-Escalation of Head and Neck Cancers.

Journal article Cancers (Basel) · April 23, 2026 Radiation therapy is a central component of the definitive and postoperative management for head and neck cancers (HNC), with intensity-modulated radiation therapy (IMRT) and volumetric modulated arc therapy (VMAT) now standard. Within these techniques, tw ... Full text Open Access Link to item Cite

Barriers, Perceptions, and Predictors for Utilizing Health-Related Technology Among Individuals Receiving Radiation Oncology Care.

Journal article Cureus · April 2026 INTRODUCTION: For many people, mobile applications are pivotal to their daily lives. With a constantly increasing number of applications, the utilization of mobile health (mHealth) has augmented various aspects of clinical care outside of traditional clini ... Full text Open Access Link to item Cite

Multi-phase Automated Segmentation of Dental Structures in CBCT Using a Lightweight Auto3DSeg and SegResNet Implementation

Conference Lecture Notes in Computer Science · January 1, 2026 Cone-beam computed tomography (CBCT) has become an invaluable imaging modality in dentistry, enabling 3D visualization of teeth and surrounding structures for diagnosis and treatment planning. Automated segmentation of dental structures in CBCT can efficie ... Full text Cite

Executive Summary of the American Radium Society Appropriate Use Criteria for Management of Early Glottic Cancer: A Review.

Journal article JAMA Otolaryngol Head Neck Surg · October 1, 2025 IMPORTANCE: Stage I squamous cell carcinoma (SCC) of the glottic larynx carries a favorable prognosis after treatment with endoscopic surgery or radiation therapy (RT). In addition to tumor control, goals of therapy include preservation of voice quality, s ... Full text Open Access Link to item Cite

Clinical outcomes for unresectable anaplastic thyroid cancer treated with radiation: Impacts of radiation intent and the percentage of life spent receiving treatment.

Journal article Oral Oncol · August 2025 INTRODUCTION: Patients with unresectable anaplastic thyroid cancer have poor prognosis and treatment usually includes radiation therapy. Due to the long radiation courses, many patients may spend a significant portion of their remaining lives receiving rad ... Full text Open Access Link to item Cite

Dosimetric analysis of different whole brain radiotherapy treatment planning methods: three types of 3-dimensional versus hippocampal avoidant.

Journal article Radiat Oncol J · June 2025 PURPOSE: Our purpose was to compare four whole brain radiotherapy (WBRT) delivery types: opposed lateral (OL) 3-dimensional-conformal radiotherapy (3D-CRT), a novel opposed lateral sparing (OLS) 3D-CRT technique, 3D optimized dynamic conformal arcs (optDCA ... Full text Link to item Cite

Palliative radiation oncology programs: improving value through high-quality and cost-effective care.

Journal article Ann Palliat Med · May 2025 An estimated 40% of all radiation treatments are delivered with non-curative intent, and there is strong evidence that this cohort of patients benefits from the early integration of palliative care services. Palliative radiation oncology programs (PROPs) a ... Full text Open Access Link to item Cite

Implications of primary tumor site and fraction size on outcomes of palliative radiation for osseous metastases.

Journal article Front Oncol · 2025 PURPOSE: This study reviewed palliative radiation therapy (RT) practices and outcomes and compared the percentage of remaining life spent receiving RT (PRLSRT) in patients treated for osseous metastases. METHODS: A retrospective analysis was conducted usin ... Full text Open Access Link to item Cite

Palliative radiation for bone metastases from hepatocellular carcinoma: practice patterns and the amount of remaining life spent receiving treatment.

Journal article Ann Palliat Med · June 2022 BACKGROUND: Palliative radiation therapy (RT) for bone metastases (BMs) is a common practice. Wide variation exists in clinically used dose schema despite numerous studies demonstrating palliative equipoise between single and multifraction courses. We hypo ... Full text Open Access Link to item Cite

The impact of socioeconomic and geographic factors on access to transoral robotic/endoscopic surgery for early stage oropharyngeal malignancy.

Journal article Am J Otolaryngol · 2022 OBJECTIVE: To evaluate the role of social and geographic factors on the likelihood of receiving transoral robotic surgery (TORS) or non-robotic transoral endoscopic surgery treatment in early stage oropharyngeal squamous cell carcinoma (OPSCC). MATERIALS A ... Full text Link to item Cite

Dosimetry Comparison of Palliative Radiation Plans Generated From Available Diagnostic CT Images Versus Dedicated CT Simulation for Inpatients.

Journal article Cureus · September 2021 Introduction The morbidity sequelae of advanced cancer are often irreversible. Early palliative radiation can prevent, delay, and even improve these consequences. Treatment may be delayed due to a packed computed tomography (CT) simulation schedule or othe ... Full text Link to item Cite

Systematic review of postoperative therapy for resected squamous cell carcinoma of the head and neck: Executive summary of the American Radium Society appropriate use criteria.

Journal article Head Neck · January 2021 BACKGROUND: The aims of this systematic review are to (a) evaluate the current literature on the impact of postoperative therapy for resected squamous cell carcinoma of the head and neck (SCCHN) on oncologic and non-oncologic outcomes and (b) identify the ... Full text Link to item Cite

Ipsilateral radiation for squamous cell carcinoma of the tonsil: American Radium Society appropriate use criteria executive summary.

Journal article Head Neck · January 2021 BACKGROUND: We conducted the current systemic review to provide up-to-date literature summary and optimal evidence-based recommendations for ipsilateral radiation for squamous cell carcinoma of the tonsil. METHODS: We performed literature search of peer-re ... Full text Link to item Cite

The influence of breast cancer subtype on survival after palliative radiation for osseous metastases.

Journal article Cancer Med · December 2020 BACKGROUND: Among patients with osseous metastases, breast cancer (BC) patients typically have the best prognosis. In the palliative setting, BC is often considered a single disease, but based on receptor status there are four distinct subtypes: luminal A ... Full text Link to item Cite

Neoadjuvant chemotherapy improves survival compared with concurrent chemoradiation alone in nasopharyngeal carcinoma patients with N3 disease.

Journal article Head Neck · December 2019 BACKGROUND: Neoadjuvant chemotherapy (NAC) trials in endemic regions of nasopharyngeal carcinoma (NPC) found improved survival, but studies are lacking in nonendemic regions. We assessed whether adding NAC to concurrent chemoradiation (CRT) improves overal ... Full text Link to item Cite

The Dosimetric Impact of Interfractional Organ-at-Risk Movement During Liver Stereotactic Body Radiation Therapy.

Journal article Pract Radiat Oncol · November 2019 PURPOSE: Stereotactic body radiation therapy (SBRT) is an effective therapy for treating liver malignancies. However, little is known about interfractional dose variations to adjacent organs at risk (OARs). We examine the effects of interfractional organ m ... Full text Link to item Cite

Downstaging Locally Advanced Cholangiocarcinoma Pre-Liver Transplantation: A Prospective Pilot Study.

Journal article J Surg Res · October 2019 BACKGROUND: Orthotopic liver transplantation (OLT) after neoadjuvant therapy (NT) in well-selected patients with unresectable hilar cholangiocarcinoma (CCA) achieves excellent recurrence-free survival. Current criteria for NT-OLT exclude patients with loca ... Full text Open Access Link to item Cite

Stereotactic body radiation therapy for hepatocellular carcinoma: Practice patterns, dose selection and factors impacting survival.

Journal article Cancer Med · March 2019 BACKGROUND: Stereotactic body radiation therapy (SBRT) is an emerging option for unresectable hepatocellular carcinoma (HCC) without consensus regarding optimal dose schemas. This analysis identifies practice patterns and factors that influence dose select ... Full text Link to item Cite

Early Prediction of Acute Xerostomia During Radiation Therapy for Head and Neck Cancer Based on Texture Analysis of Daily CT.

Journal article Int J Radiat Oncol Biol Phys · November 15, 2018 PURPOSE: To investigate radiation-induced changes of computed tomography (CT) textures in parotid glands (PG) to predict acute xerostomia during radiotherapy (RT) for head and neck cancer (HNC). METHODS AND MATERIALS: Daily or fraction kilovoltage CTs acqu ... Full text Link to item Cite

Magnetic Resonance-based Response Assessment and Dose Adaptation in Human Papilloma Virus Positive Tumors of the Oropharynx treated with Radiotherapy (MR-ADAPTOR): An R-IDEAL stage 2a-2b/Bayesian phase II trial.

Journal article Clin Transl Radiat Oncol · November 2018 BACKGROUND: Current standard radiotherapy for oropharynx cancer (OPC) is associated with high rates of severe toxicities, shown to adversely impact patients' quality of life. Given excellent outcomes of human papilloma virus (HPV)-associated OPC and long-t ... Full text Link to item Cite

Technical Note: Enhancing soft tissue contrast and radiation-induced image changes with dual-energy CT for radiation therapy.

Journal article Med Phys · July 4, 2018 PURPOSE: The purpose of this work is to investigate the use of low-energy monoenergetic decompositions obtained from dual-energy CT (DECT) to enhance image contrast and the detection of radiation-induced changes of CT textures in pancreatic cancer. METHODS ... Full text Link to item Cite

Stereotactic Body Radiotherapy for Elderly Patients With Medically Inoperable Pancreatic Cancer.

Journal article Am J Clin Oncol · February 2017 OBJECTIVES: People over the age of 75 years account for approximately 40% of patients diagnosed with pancreatic cancer, many with comorbidities that may limit their treatment options. This study reports on the use of stereotactic body radiation therapy (SB ... Full text Link to item Cite

Reducing radiation dose and enhancing imaging quality of 4DCT for radiation therapy using iterative reconstruction algorithms.

Journal article Adv Radiat Oncol · 2017 PURPOSE: Four-dimensional computed tomography (CT) images are typically used to quantify the necessary internal target volumes for thoracic and abdominal tumors. However, 4-dimensional CT is typically associated with excessive imaging dose to patients and ... Full text Link to item Cite

Palliative interventions for hepatocellular carcinoma patients: analysis of the National Cancer Database.

Journal article Ann Palliat Med · January 2017 BACKGROUND: Palliative therapies are provided to a subset of hepatocellular carcinoma (HCC) patients with the aim of providing symptomatic relief, better quality of life and improved survival. The present study sought to assess and compare the efficacy of ... Full text Link to item Cite

Predictive Capacity of 3 Comorbidity Indices in Estimating Survival Endpoints in Women With Early-Stage Endometrial Carcinoma.

Journal article Int J Gynecol Cancer · October 2016 OBJECTIVE: The negative impact of comorbidity on survival in women with endometrial carcinoma (EC) is well-known. Few validated comorbidity indices are available for clinical use, such as the Charlson Comorbidity Index (CCI), the Age-Adjusted CCI (AACCI), ... Full text Link to item Cite

ACR Appropriateness Criteria® pre-irradiation evaluation and management of brain metastases.

Journal article J Palliat Med · August 2014 Pretreatment evaluation is performed to determine the number, location, and size of the brain metastases and magnetic resonance imaging (MRI) is the recommended imaging technique, particularly in patients being considered for surgery or stereotactic radios ... Full text Link to item Cite

Radiosurgery of multiple brain metastases with single-isocenter dynamic conformal arcs (SIDCA).

Journal article Radiother Oncol · July 2014 PURPOSE: To propose single-isocenter dynamic conformal arcs (SIDCA), a novel technique for radiosurgery of multiple brain metastases, and to compare SIDCA with volumetric modulated arc therapy (VMAT) and multiple-isocenter dynamic conformal arcs (MIDCA) fo ... Full text Link to item Cite

The impact of income on clinical outcomes in FIGO stages I to II endometrioid adenocarcinoma of the uterus.

Journal article Am J Clin Oncol · December 2013 OBJECTIVE(S): To determine the influence of income on clinical outcomes in patients with surgical stages I to II endometrioid adenocarcinoma of the uterus. METHODS: We retrospectively analyzed the records of 660 women initially treated from 1985 to 2009. O ... Full text Link to item Cite

Impact of age-adjusted Charlson comorbidity score on outcomes for patients with early-stage endometrial cancer.

Journal article Gynecol Oncol · December 2013 OBJECTIVES: To determine the impact of Age-Adjusted Charlson Comorbidity (AAC) index score on survival outcomes for patients with early stage endometrial cancer. METHODS: After IRB-approval, AAC score at time of hysterectomy was retrospectively tabulated b ... Full text Link to item Cite

A novel approach for establishing benchmark CBCT/CT deformable image registrations in prostate cancer radiotherapy.

Journal article Phys Med Biol · November 21, 2013 Deformable image registration (DIR) is an integral component for adaptive radiation therapy. However, accurate registration between daily cone-beam computed tomography (CBCT) and treatment planning CT is challenging, due to significant daily variations in ... Full text Link to item Cite

Adjuvant radiation therapy for patients with type II endometrial carcinoma: impact on tumor recurrence and survival.

Journal article Int J Gynecol Cancer · May 2013 PURPOSE/OBJECTIVE: The optimal adjuvant treatment of type II endometrial carcinoma after hysterectomy remains controversial. The objective of this study was to determine the effect of adjuvant radiation therapy (RT) on recurrence-free survival (RFS), disea ... Full text Link to item Cite

The impact of race on outcomes of patients with early stage uterine endometrioid carcinoma.

Journal article Gynecol Oncol · February 2013 OBJECTIVES: The purpose of the present study was to determine whether racial disparity exists between African American (AA) and non-African American (NAA) patients with uterine endometrioid carcinoma who received similar multidisciplinary management. METHO ... Full text Link to item Cite

Radiosurgery to the surgical cavity as adjuvant therapy for resected brain metastasis.

Journal article Neurosurgery · November 2012 BACKGROUND: The standard treatment of resected brain metastasis is whole-brain radiotherapy (WBRT). To avoid the potential toxicity of WBRT and to improve local control, we have used radiosurgery alone to the surgical cavity. OBJECTIVE: To demonstrate the ... Full text Link to item Cite

Is time to recurrence after hysterectomy predictive of survival in patients with early stage endometrial carcinoma?

Journal article Gynecol Oncol · October 2012 PURPOSE/OBJECTIVE(S): To determine the prognostic significance of time to recurrence (TTR) on overall survival (OS) and disease-specific survival (DSS) following recurrence in patients with stage I-II uterine endometrioid carcinoma. MATERIALS/METHODS: Afte ... Full text Link to item Cite

ACR Appropriateness Criteria® follow-up and retreatment of brain metastases.

Journal article Am J Clin Oncol · June 2012 Multiple options for retreatment are available, which include whole-brain radiation therapy, stereotactic radiosurgery, surgery, chemotherapy, and supportive care. Size, number, timing, location, histology, performance status, and extracranial disease stat ... Full text Link to item Cite

Interfractional target variations for partial breast irradiation.

Journal article Int J Radiat Oncol Biol Phys · April 1, 2012 PURPOSE: In this work, we quantify the interfractional variations in the shape of the clinical target volume (CTV) by analyzing the daily CT data acquired during CT-guided partial breast irradiation (PBI) and compare the effectiveness of various reposition ... Full text Link to item Cite

Hysterectomy for uterine adenocarcinoma in the elderly: tumor characteristics, and long-term outcome.

Journal article Gynecol Oncol · October 2011 OBJECTIVES: To evaluate the tumor recurrences and survival in elderly patients ≥75 years of age with uterine endometrioid carcinoma treated with surgical staging with/without adjuvant radiation therapy (RT). METHODS: We identified 675 surgically staged pat ... Full text Link to item Cite

Vaginal recurrence more than 17 years after hysterectomy and adjuvant treatment for uterine carcinoma with successful salvage brachytherapy: a case report.

Journal article Case Rep Oncol · April 18, 2011 PURPOSE: Although the majority of recurrences occur within the first 3 years of hysterectomy for endometrioid carcinoma, we report herein a successful salvage vaginal brachytherapy in a patient with endometrioid uterine carcinoma which recurred more than 1 ... Full text Link to item Cite

Radiation therapy as part of local control of metastatic neuroblastoma: the St Jude Children's Research Hospital experience.

Journal article J Pediatr Surg · April 2010 PURPOSE: The purpose of the study was to compare outcomes of pediatric patients with high-risk metastatic neuroblastoma who received radiotherapy (RT) with those of patients who did not. PATIENTS AND METHODS: We reviewed the records of 63 patients with new ... Full text Link to item Cite

Cellular and molecular bases of the initiation of fever.

Journal article PLoS Biol · September 2006 All phases of lipopolysaccharide (LPS)-induced fever are mediated by prostaglandin (PG) E2. It is known that the second febrile phase (which starts at approximately 1.5 h post-LPS) and subsequent phases are mediated by PGE2 that originated in endotheliocyt ... Full text Link to item Cite

Expanding the febrigenic role of cyclooxygenase-2 to the previously overlooked responses.

Journal article Am J Physiol Regul Integr Comp Physiol · November 2005 Previous studies on the role of cyclooxygenase (COX)-1 and -2 in fever induced by intravenous LPS have failed to investigate the role of these isoenzymes in the earliest responses: monophasic fever (response to a low, near-threshold dose of LPS) and the fi ... Full text Link to item Cite

Thermoregulatory responses to lipopolysaccharide in the mouse: dependence on the dose and ambient temperature.

Journal article Am J Physiol Regul Integr Comp Physiol · November 2005 Most published studies of thermoregulatory responses of mice to LPS involved a stressful injection of LPS, were run at a poorly controlled and often subneutral ambient temperature (T(a)), and paid little attention to the dependence of the response on the L ... Full text Link to item Cite

Thermoregulatory responses of rats to conventional preparations of lipopolysaccharide are caused by lipopolysaccharide per se-- not by lipoprotein contaminants.

Journal article Am J Physiol Regul Integr Comp Physiol · August 2005 LPS preparations cause a variety of body temperature (T(b)) responses: monophasic fever, different phases of polyphasic fever, and hypothermia. Conventional (c) LPS preparations contain highly active lipoprotein contaminants (endotoxin proteins). Whereas L ... Full text Link to item Cite