Scholars@Duke
Jason Chen Fan

Scholarly Works

Clinical efficacy and safety of aflibercept biosimilars in neovascular age-related macular degeneration: a systematic review and meta-analysis of randomised controlled trials.

Journal article Br J Ophthalmol · June 3, 2026 BACKGROUND: To evaluate the efficacy and safety of aflibercept biosimilars compared with reference aflibercept in the treatment of neovascular age-related macular degeneration (nAMD). METHODS: A systematic review and meta-analysis were conducted following ... Full text Link to item Cite

Impact of Prior Diabetic Retinal Screening on Hospitalization and Ophthalmic Follow-Up in Diabetic Patients with Newly Diagnosed Proliferative Diabetic Retinopathy.

Journal article Diagnostics (Basel) · May 21, 2026 Background/Objectives: This retrospective cohort study compared hospitalization and follow-up rates in patients with newly diagnosed proliferative diabetic retinopathy (PDR) versus those without prior diabetic retinopathy (DR) screening. Methods: Using Tri ... Full text Link to item Cite

Treatment of primary Inferior rhegmatogenous retinal detachment with heavy silicone oil versus standard silicone oil: A meta-analysis.

Journal article Eur J Ophthalmol · November 2025 PurposeThis study investigates if heavy silicone oil (HSO) is associated with better outcomes than standard silicone oil (SO) as a tamponade agent in the repair of primary inferior rhegmatogenous retinal detachments (RRD).MethodsPubmed, Embase, and Scopus ... Full text Link to item Cite

Novel KMT2D pathogenic variant causing Kabuki Syndrome with associated macular abnormalities and retinopathy of prematurity.

Journal article Ophthalmic Genet · October 2025 BACKGROUND: Kabuki Syndrome (KS) is a rare multiple congenital anomaly syndrome originally described in 1981 by Japanese clinicians. KS belongs to the family of chromatinopathies, a group of disorders characterized by abnormalities in chromatin regulation ... Full text Link to item Cite

Clinical Outcomes in Traumatic Penetrating Keratoplasty Graft Dehiscence.

Journal article Cornea · February 1, 2025 PURPOSE: The purpose of this study was to report clinical characteristics and outcomes of surgical repair for patients with traumatic dehiscence of penetrating keratoplasty (PKP) grafts. METHODS: Retrospective, consecutive chart review of patients evaluate ... Full text Link to item Cite

Vitreoretinal Injury Associated with Sports Ball Ocular Trauma.

Journal article Clin Ophthalmol · 2025 Sports are a common cause of ocular trauma. Vitreoretinal injuries secondary to sports ball trauma can cause permanent vision loss and may be a source of significant morbidity. Trauma most frequently occurs in young males and over half of injuries involve ... Full text Link to item Cite

Foveal photoreceptor atrophy, persistent fetal vasculature, congenital cataracts, and microphthalmia in a pediatric patient with BCOR-associated oculo-facio-cardio-dental (OFCD) syndrome.

Journal article Am J Ophthalmol Case Rep · June 2024 PURPOSE: To report a case of oculo-facio-cardio-dental (OFCD) syndrome secondary to a novel BCOR variant in a pediatric patient with congenital cataracts, microphthalmia, persistent fetal vasculature (PFV), focal chorioretinal hyperpigmentation, peripheral ... Full text Link to item Cite

A patient with concurrent Axenfeld-Rieger and Stickler syndromes verified by molecular genetics.

Journal article Am J Ophthalmol Case Rep · December 2023 PURPOSE: To report a case of Axenfeld-Rieger and Stickler Syndrome in a pediatric patient. OBSERVATIONS: A 3-month-old male was referred to the glaucoma clinic after he was noted to have elevated intraocular pressures in both eyes. His family history was n ... Full text Link to item Cite

Radial Keratotomy-Associated Endophthalmitis.

Journal article Ophthalmol Retina · December 2023 Full text Link to item Cite

Atypical Presentations of Extraparenchymal Neurocysticercosis.

Journal article J Neuroophthalmol · September 1, 2023 BACKGROUND: Neurocysticercosis (NCC) is the most common parasitic infection of the central nervous system and is typically diagnosed through visualization of the cysts in the cerebral parenchyma by neuro-imaging. However, neuro-imaging may not detect extra ... Full text Link to item Cite

Peripheral Retinal Nonperfusion in Pediatric Patients with Optic Disc Hypoplasia.

Journal article Am J Ophthalmol · August 2023 PURPOSE: This study aims to report the association of optic nerve hypoplasia (ONH), peripheral retinal nonperfusion, and secondary complications in pediatric patients. DESIGN: Retrospective case series. METHODS: The study was conducted between January 2015 ... Full text Link to item Cite

Evolving Use of Regional versus General Anesthesia for the Surgical Repair of Open Globe Injuries.

Journal article Am J Ophthalmol · July 2023 PURPOSE: The purpose of the current study is to report outcomes with the evolving use of regional anesthesia with monitored anesthesia care (RA-MAC) vs general anesthesia (GA) in the repair of open globe injuries. DESIGN: Retrospective, consecutive, compar ... Full text Link to item Cite

Familial exudative vitreoretinopathy associated with retinal astrocytic hamartoma.

Journal article Am J Ophthalmol Case Rep · March 2022 PURPOSE: To report the first case of retinal astrocytic hamartoma (RAH) arising in the setting of Familial Exudative Vitreoretinopathy (FEVR). OBSERVATIONS: An otherwise healthy 3-month-old male was clinically diagnosed with Familial Exudative Vitreoretino ... Full text Link to item Cite

CYTOMEGALOVIRUS RETINITIS WITH BELATACEPT IMMUNOSUPPRESSION.

Journal article Retin Cases Brief Rep · March 1, 2022 PURPOSE: To report two cases of cytomegalovirus (CMV) retinitis in renal transplant patients after conversion to belatacept immunosuppression. METHODS: Case report. RESULTS: Case A was a 41-year-old African American man with no ocular history, chronic hepa ... Full text Link to item Cite

Ocular and Systemic Complications of COVID-19: Impact on Patients and Healthcare.

Journal article Clin Ophthalmol · 2022 There is increasing information available about the effects of the SARS-CoV-2 virus on the systemic and ocular health of patients, as well as the effects of delayed health care. This mini-review summarizes the potential complications and treatments of COVI ... Full text Link to item Cite

Outcomes in Patients with Suprachoroidal Hemorrhage After Anterior Segment Surgery.

Journal article Clin Ophthalmol · 2022 OBJECTIVE: The purpose of the current study is to report outcomes of suprachoroidal hemorrhage (SCH) after anterior segment surgery at a single institution, and to identify clinical features associated with visual prognosis. METHODS AND ANALYSIS: Retrospec ... Full text Link to item Cite

Cyb5r3 links FoxO1-dependent mitochondrial dysfunction with β-cell failure.

Journal article Mol Metab · April 2020 OBJECTIVE: Diabetes is characterized by pancreatic β-cell dedifferentiation. Dedifferentiating β cells inappropriately metabolize lipids over carbohydrates and exhibit impaired mitochondrial oxidative phosphorylation. However, the mechanism linking the β-c ... Full text Link to item Cite

When β-cells fail: lessons from dedifferentiation.

Journal article Diabetes Obes Metab · September 2016 Diabetes is caused by a combination of impaired responsiveness to insulin and reduced production of insulin by the pancreas. Until recently, the decline of insulin production had been ascribed to β-cell death. But recent research has shown that β-cells do ... Full text Link to item Cite

Aldehyde dehydrogenase 1a3 defines a subset of failing pancreatic β cells in diabetic mice.

Journal article Nat Commun · August 30, 2016 Insulin-producing β cells become dedifferentiated during diabetes progression. An impaired ability to select substrates for oxidative phosphorylation, or metabolic inflexibility, initiates progression from β-cell dysfunction to β-cell dedifferentiation. Th ... Full text Link to item Cite

FoxO1 Deacetylation Decreases Fatty Acid Oxidation in β-Cells and Sustains Insulin Secretion in Diabetes.

Journal article J Biol Chem · May 6, 2016 Pancreatic β-cell dysfunction contributes to onset and progression of type 2 diabetes. In this state β-cells become metabolically inflexible, losing the ability to select between carbohydrates and lipids as substrates for mitochondrial oxidation. These cha ... Full text Link to item Cite

METABOLISM. S-Nitrosylation links obesity-associated inflammation to endoplasmic reticulum dysfunction.

Journal article Science · July 31, 2015 The association between inflammation and endoplasmic reticulum (ER) stress has been observed in many diseases. However, if and how chronic inflammation regulates the unfolded protein response (UPR) and alters ER homeostasis in general, or in the context of ... Full text Link to item Cite

Phenotypic assays identify azoramide as a small-molecule modulator of the unfolded protein response with antidiabetic activity.

Journal article Sci Transl Med · June 17, 2015 The endoplasmic reticulum (ER) plays a critical role in protein, lipid, and glucose metabolism as well as cellular calcium signaling and homeostasis. Perturbation of ER function and chronic ER stress are associated with many pathologies ranging from diabet ... Full text Link to item Cite

Polysome profiling in liver identifies dynamic regulation of endoplasmic reticulum translatome by obesity and fasting.

Journal article PLoS Genet · August 2012 Obesity-associated metabolic complications are generally considered to emerge from abnormalities in carbohydrate and lipid metabolism, whereas the status of protein metabolism is not well studied. Here, we performed comparative polysome and associated tran ... Full text Link to item Cite