Jason Locasale | Scholars@Duke

Jason Locasale
Associate Professor of Pharmacology and Cancer Biology

Our research interests are in three interconnected areas: 1) Quantitative and computational biology of metabolism. 2) The role of diet and pharmacological therapeutics in shaping metabolic pathways in health and cancer. 3) The interaction of metabolism and epigenetics. Each of these synergistic areas utilizes the metabolomics technologies we develop along with our expertise in computational and molecular biology.

Current Appointments & Affiliations

Associate Professor of Pharmacology and Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2018
Member of Duke Molecular Physiology Institute, Duke Molecular Physiology Institute, Duke Molecular Physiology Institute 2013
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2015

Contact Information

Background
Education, Training, & Certifications
- Ph.D., Massachusetts Institute of Technology 2008
- B.A., Rutgers University New Brunswick 2003
Duke Appointment History
- Assistant Professor of Pharmacology & Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2015 - 2018
Recognition
In the News
- SEP 17, 2017 Duke Health News
  
  Natural Molecule Appears to Shut Off Cancer Cells Energy Source
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Hart, Peter C., Tatsuyuki Chiyoda, Xiaojing Liu, Melanie Weigert, Marion Curtis, Chun-Yi Chiang, Rachel Loth, et al. “SPHK1 Is a Novel Target of Metformin in Ovarian Cancer..” Molecular Cancer Research : Mcr 17, no. 4 (April 2019): 870–81. https://doi.org/10.1158/1541-7786.mcr-18-0409.
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  - Ma, Hong, Shuo Yu, Xiaojing Liu, Yingao Zhang, Thomas Fakadej, Ziqing Liu, Chaoying Yin, et al. “Lin28a Regulates Pathological Cardiac Hypertrophic Growth Through Pck2-Mediated Enhancement of Anabolic Synthesis..” Circulation 139, no. 14 (April 2019): 1725–40. https://doi.org/10.1161/circulationaha.118.037803.
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  - Sinclair, Linda V., Andrew Jm Howden, Alejandro Brenes, Laura Spinelli, Jens L. Hukelmann, Andrew N. Macintyre, Xiaojing Liu, et al. “Antigen receptor control of methionine metabolism in T cells..” Elife 8 (March 27, 2019). https://doi.org/10.7554/eLife.44210.
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  - Gao, Xia, Jason W. Locasale, and Michael A. Reid. “Serine and Methionine Metabolism: Vulnerabilities in Lethal Prostate Cancer..” Cancer Cell 35, no. 3 (March 2019): 339–41. https://doi.org/10.1016/j.ccell.2019.02.014.
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  - Vodnala, Suman Kumar, Robert Eil, Rigel J. Kishton, Madhusudhanan Sukumar, Tori N. Yamamoto, Ngoc-Han Ha, Ping-Hsien Lee, et al. “T cell stemness and dysfunction in tumors are triggered by a common mechanism..” Science (New York, N.Y.) 363, no. 6434 (March 2019). https://doi.org/10.1126/science.aau0135.
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  - Yang, Ying, Mari B. Ishak Gabra, Eric A. Hanse, Xazmin H. Lowman, Thai Q. Tran, Haiqing Li, Neta Milman, et al. “MiR-135 suppresses glycolysis and promotes pancreatic cancer cell adaptation to metabolic stress by targeting phosphofructokinase-1..” Nature Communications 10, no. 1 (February 18, 2019). https://doi.org/10.1038/s41467-019-08759-0.
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  - Cao, Jennifer Yinuo, Aunoy Poddar, Leslie Magtanong, Jennifer H. Lumb, Trevor R. Mileur, Michael A. Reid, Cole M. Dovey, et al. “A Genome-wide Haploid Genetic Screen Identifies Regulators of Glutathione Abundance and Ferroptosis Sensitivity..” Cell Reports 26, no. 6 (February 2019): 1544-1556.e8. https://doi.org/10.1016/j.celrep.2019.01.043.
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  - Freemerman, Alex J., Liyang Zhao, Ajeeth K. Pingili, Bin Teng, Alyssa J. Cozzo, Ashley M. Fuller, Amy R. Johnson, et al. “Myeloid Slc2a1-Deficient Murine Model Revealed Macrophage Activation and Metabolic Phenotype Are Fueled by GLUT1..” Journal of Immunology (Baltimore, Md. : 1950) 202, no. 4 (February 2019): 1265–86. https://doi.org/10.4049/jimmunol.1800002.
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  - Daniels, Brian P., Sigal B. Kofman, Julian R. Smith, Geoffrey T. Norris, Annelise G. Snyder, Joseph P. Kolb, Xia Gao, et al. “The Nucleotide Sensor ZBP1 and Kinase RIPK3 Induce the Enzyme IRG1 to Promote an Antiviral Metabolic State in Neurons..” Immunity 50, no. 1 (January 8, 2019): 64-76.e4. https://doi.org/10.1016/j.immuni.2018.11.017.
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  - May, Jasmine L., Fotini M. Kouri, Lisa A. Hurley, Juan Liu, Serena Tommasini-Ghelfi, Yanrong Ji, Peng Gao, et al. “IDH3α regulates one-carbon metabolism in glioblastoma..” Science Advances 5, no. 1 (January 2, 2019). https://doi.org/10.1126/sciadv.aat0456.
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  - Curtis, Marion, Hilary A. Kenny, Bradley Ashcroft, Abir Mukherjee, Alyssa Johnson, Yilin Zhang, Ynes Helou, et al. “Fibroblasts Mobilize Tumor Cell Glycogen to Promote Proliferation and Metastasis..” Cell Metabolism 29, no. 1 (January 2019): 141-155.e9. https://doi.org/10.1016/j.cmet.2018.08.007.
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  - Gemta, Lelisa F., Peter J. Siska, Marin E. Nelson, Xia Gao, Xiaojing Liu, Jason W. Locasale, Hideo Yagita, et al. “Impaired enolase 1 glycolytic activity restrains effector functions of tumor-infiltrating CD8+ T cells..” Science Immunology 4, no. 31 (January 2019). https://doi.org/10.1126/sciimmunol.aap9520.
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  - Dai, Ziwei, and Jason W. Locasale. “Thermodynamic constraints on the regulation of metabolic fluxes..” J Biol Chem 293, no. 51 (December 21, 2018): 19725–39. https://doi.org/10.1074/jbc.RA118.004372.
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  - Reid, Michael A., Annamarie E. Allen, Shiyu Liu, Maria V. Liberti, Pei Liu, Xiaojing Liu, Ziwei Dai, et al. “Serine synthesis through PHGDH coordinates nucleotide levels by maintaining central carbon metabolism..” Nature Communications 9, no. 1 (December 21, 2018). https://doi.org/10.1038/s41467-018-07868-6.
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  - Johnson, Marc O., Melissa M. Wolf, Matthew Z. Madden, Gabriela Andrejeva, Ayaka Sugiura, Diana C. Contreras, Damian Maseda, et al. “Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism..” Cell 175, no. 7 (December 2018): 1780-1795.e19. https://doi.org/10.1016/j.cell.2018.10.001.
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  - Sanderson, Sydney M., and Jason W. Locasale. “Revisiting the Warburg Effect: Some Tumors Hold Their Breath..” Cell Metabolism 28, no. 5 (November 2018): 669–70. https://doi.org/10.1016/j.cmet.2018.10.011.
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  - Stone, Oliver A., Mohamed El-Brolosy, Kerstin Wilhelm, Xiaojing Liu, Ana M. Romão, Elisabetta Grillo, Jason K. H. Lai, et al. “Loss of pyruvate kinase M2 limits growth and triggers innate immune signaling in endothelial cells..” Nature Communications 9, no. 1 (October 9, 2018). https://doi.org/10.1038/s41467-018-06406-8.
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  - Liu, Xiaojing, Daniel E. Cooper, Ahmad A. Cluntun, Marc O. Warmoes, Steven Zhao, Michael A. Reid, Juan Liu, et al. “Acetate Production from Glucose and Coupling to Mitochondrial Metabolism in Mammals..” Cell 175, no. 2 (October 2018): 502-513.e13. https://doi.org/10.1016/j.cell.2018.08.040.
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  - Bechard, Matthew E., Anna E. Word, Amanda V. Tran, Xiaojing Liu, Jason W. Locasale, and Oliver G. McDonald. “Pentose conversions support the tumorigenesis of pancreatic cancer distant metastases..” Oncogene 37, no. 38 (September 2018): 5248–56. https://doi.org/10.1038/s41388-018-0346-5.
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  - Gamble, L. J., C. W. Frye, C. M. Hansen, J. W. Locasale, X. Liu, M. S. Davis, and J. J. Wakshlag. “Serum metabolomics of Alaskan sled dogs during endurance racing.” Comparative Exercise Physiology 14, no. 3 (September 1, 2018): 149–59. https://doi.org/10.3920/CEP180010.
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  - Hershberger, Kathleen A., Dennis M. Abraham, Juan Liu, Jason W. Locasale, Paul A. Grimsrud, and Matthew D. Hirschey. “Ablation of Sirtuin5 in the postnatal mouse heart results in protein succinylation and normal survival in response to chronic pressure overload..” The Journal of Biological Chemistry 293, no. 27 (July 2018): 10630–45. https://doi.org/10.1074/jbc.ra118.002187.
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  - Dai, Ziwei, and Jason Locasale. “Thermodynamic constraints on the regulation of metabolic fluxes,” June 7, 2018. https://doi.org/10.1101/341271.
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  - Huang, He, Shuang Tang, Ming Ji, Zhanyun Tang, Miho Shimada, Xiaojing Liu, Shankang Qi, et al. “p300-Mediated Lysine 2-Hydroxyisobutyrylation Regulates Glycolysis..” Molecular Cell 70, no. 5 (June 7, 2018). https://doi.org/10.1016/j.molcel.2018.05.035.
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  - Chapman, Nicole M., Hu Zeng, Thanh-Long M. Nguyen, Yanyan Wang, Peter Vogel, Yogesh Dhungana, Xiaojing Liu, Geoffrey Neale, Jason W. Locasale, and Hongbo Chi. “mTOR coordinates transcriptional programs and mitochondrial metabolism of activated Treg subsets to protect tissue homeostasis..” Nature Communications 9, no. 1 (May 29, 2018). https://doi.org/10.1038/s41467-018-04392-5.
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  - Dai, Ziwei, Samantha J. Mentch, Xia Gao, Sailendra N. Nichenametla, and Jason W. Locasale. “Methionine metabolism influences genomic architecture and gene expression through H3K4me3 peak width..” Nature Communications 9, no. 1 (May 16, 2018). https://doi.org/10.1038/s41467-018-04426-y.
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  - Sanderson, Sydney, Peter Mikhael, Ziwei Dai, and Jason Locasale. “Environmental factors shape methionine metabolism in p16/MTAP deleted cells,” May 2, 2018. https://doi.org/10.1101/313288.
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  - Huang, He, Shuang Tang, Ming Ji, Zhanyun Tang, Miho Shimada, Xiaojing Liu, Shankang Qi, et al. “p300-Mediated Lysine 2-Hydroxyisobutyrylation Regulates Glycolysis..” Molecular Cell 70, no. 4 (May 2018): 663-678.e6. https://doi.org/10.1016/j.molcel.2018.04.011.
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  - Yan, Wei, Xiwei Wu, Weiying Zhou, Miranda Y. Fong, Minghui Cao, Juan Liu, Xiaojing Liu, et al. “Cancer-cell-secreted exosomal miR-105 promotes tumour growth through the MYC-dependent metabolic reprogramming of stromal cells..” Nat Cell Biol 20, no. 5 (May 2018): 597–609. https://doi.org/10.1038/s41556-018-0083-6.
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  - Locasale, J. W. “New concepts in feedback regulation of glucose metabolism.” Current Opinion in Systems Biology 8 (April 1, 2018): 32–38. https://doi.org/10.1016/j.coisb.2017.11.005.
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  - Allen, Annamarie E., and Jason W. Locasale. “Glucose Metabolism in Cancer: The Saga of Pyruvate Kinase Continues..” Cancer Cell 33, no. 3 (March 2018): 337–39. https://doi.org/10.1016/j.ccell.2018.02.008.
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  - Gao, Xia, Katie Lee, Michael A. Reid, Sydney M. Sanderson, Chuping Qiu, Siqi Li, Juan Liu, and Jason W. Locasale. “Serine Availability Influences Mitochondrial Dynamics and Function through Lipid Metabolism..” Cell Reports 22, no. 13 (March 2018): 3507–20. https://doi.org/10.1016/j.celrep.2018.03.017.
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  - Hwang, Inah, Hwanhee Oh, Evan Santo, Do-Yeon Kim, John W. Chen, Roderick T. Bronson, Jason W. Locasale, et al. “FOXO protects against age-progressive axonal degeneration..” Aging Cell 17, no. 1 (February 2018). https://doi.org/10.1111/acel.12701.
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  - Dai, Ziwei, Samantha Mentch, Xia Gao, Sailendra Nichenametla, and Jason Locasale. “Methionine metabolism influences the genomic architecture of H3K4me3 with the link to gene expression encoded in peak width,” January 5, 2018. https://doi.org/10.1101/243196.
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  - Liu, Xiaojing, Daniel E. Cooper, Ahmad A. Cluntun, Marc O. Warmoes, Steven Zhao, Michael A. Reid, Juan Liu, Kathryn E. Wellen, David G. Kirsch, and Jason W. Locasale. “De Novo Acetate Production is Coupled to Central Carbon Metabolism in Mammals,” 2018.
  - Lu, Min, Sydney M. Sanderson, Amelia Zessin, Kathleen A. Ashcraft, Lee W. Jones, Mark W. Dewhirst, Jason W. Locasale, and David S. Hsu. “Exercise inhibits tumor growth and central carbon metabolism in patient-derived xenograft models of colorectal cancer..” Cancer & Metabolism 6 (January 2018). https://doi.org/10.1186/s40170-018-0190-7.
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  - Zhao, Fei, Christine Xiao, Kathy S. Evans, Tbalamayooran Theivanthiran, Nicholas DeVito, Alisha Holtzhausen, Juan Liu, et al. “Paracrine Wnt5a-β-Catenin Signaling Triggers a Metabolic Program that Drives Dendritic Cell Tolerization..” Immunity 48, no. 1 (January 2018): 147-160.e7. https://doi.org/10.1016/j.immuni.2017.12.004.
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  - Singleton, Katherine R., Lorin Crawford, Elizabeth Tsui, Haley E. Manchester, Ophelia Maertens, Xiaojing Liu, Maria V. Liberti, et al. “Melanoma Therapeutic Strategies that Select against Resistance by Exploiting MYC-Driven Evolutionary Convergence..” Cell Rep 21, no. 10 (December 5, 2017): 2796–2812. https://doi.org/10.1016/j.celrep.2017.11.022.
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  - Hershberger, Kathleen A., Dennis M. Abraham, Angelical S. Martin, Lan Mao, Juan Liu, Hongbo Gu, Jason W. Locasale, and Matthew D. Hirschey. “Sirtuin 5 is required for mouse survival in response to cardiac pressure overload..” The Journal of Biological Chemistry 292, no. 48 (December 2017): 19767–81. https://doi.org/10.1074/jbc.M117.809897.
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  - Reid, Michael A., Jihye Paik, and Jason W. Locasale. “A Missing Link to Vitamin B12 Metabolism..” Cell 171, no. 4 (November 2017): 736–37. https://doi.org/10.1016/j.cell.2017.10.030.
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  - Reid, Michael A., Ziwei Dai, and Jason W. Locasale. “The impact of cellular metabolism on chromatin dynamics and epigenetics..” Nature Cell Biology 19, no. 11 (November 2017): 1298–1306. https://doi.org/10.1038/ncb3629.
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  - Tang, Shuang, Yi Fang, Gang Huang, Xiaojiang Xu, Elizabeth Padilla-Banks, Wei Fan, Qing Xu, et al. “Methionine metabolism is essential for SIRT1-regulated mouse embryonic stem cell maintenance and embryonic development..” The Embo Journal 36, no. 21 (November 2017): 3175–93. https://doi.org/10.15252/embj.201796708.
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  - Liberti, Maria V., Ziwei Dai, Suzanne E. Wardell, Joshua A. Baccile, Xiaojing Liu, Xia Gao, Robert Baldi, et al. “A Predictive Model for Selective Targeting of the Warburg Effect through GAPDH Inhibition with a Natural Product..” Cell Metabolism 26, no. 4 (October 2017): 648-659.e8. https://doi.org/10.1016/j.cmet.2017.08.017.
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  - Glass, O. K., M. Bowie, J. Fuller, D. Darr, J. U. sary, K. Boss, K. R. Choudhury, et al. “Differential response to exercise in claudin-low breast cancer.” Oncotarget, September 19, 2017. https://doi.org/10.18632/oncotarget.21054.
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  - Dai, Ziwei, and Jason W. Locasale. “Understanding metabolism with flux analysis: From theory to application..” Metabolic Engineering 43, no. Pt B (September 2017): 94–102. https://doi.org/10.1016/j.ymben.2016.09.005.
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  - Liu, Xiaojing, and Jason W. Locasale. “Biochemistry: A toxin that fuels metabolism..” Nature 548, no. 7669 (August 16, 2017): 533–34. https://doi.org/10.1038/nature23541.
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  - Martin, Angelical S., Dennis M. Abraham, Kathleen A. Hershberger, Dhaval P. Bhatt, Lan Mao, Huaxia Cui, Juan Liu, et al. “Nicotinamide mononucleotide requires SIRT3 to improve cardiac function and bioenergetics in a Friedreich's ataxia cardiomyopathy model..” Jci Insight 2, no. 14 (July 20, 2017). https://doi.org/10.1172/jci.insight.93885.
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  - Garcia, Jamie, Jennifer Bagwell, Brian Njaine, James Norman, Daniel S. Levic, Susan Wopat, Sara E. Miller, et al. “Sheath Cell Invasion and Trans-differentiation Repair Mechanical Damage Caused by Loss of Caveolae in the Zebrafish Notochord..” Curr Biol 27, no. 13 (July 10, 2017): 1982-1989.e3. https://doi.org/10.1016/j.cub.2017.05.035.
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  - Torrano, Veronica, Lorea Valcarcel-Jimenez, Ana Rosa Cortazar, Xiaojing Liu, Jelena Urosevic, Mireia Castillo-Martin, Sonia Fernandez-Ruiz, et al. “The metabolic co-regulator PGC1 alpha suppresses prostate cancer metastasis (vol 18, pg 645, 2016).” Nature Cell Biology 19, no. 7 (July 1, 2017): 873–873. https://doi.org/10.1038/ncb3558.
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  - Torrano, Veronica, Lorea Valcarcel-Jimenez, Ana Rosa Cortazar, Xiaojing Liu, Jelena Urosevic, Mireia Castillo-Martin, Sonia Fernández-Ruiz, et al. “Erratum: The metabolic co-regulator PGC1α suppresses prostate cancer metastasis..” Nature Cell Biology 19, no. 7 (June 2017). https://doi.org/10.1038/ncb3558.
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  - Liu, Xiaojing, and Jason W. Locasale. “Metabolomics reveals intratumor heterogeneity - Implications for precision medicine..” Ebiomedicine 19 (May 2017): 4–5. https://doi.org/10.1016/j.ebiom.2017.04.030.
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  - Wang, Xiuxing, Kailin Yang, Qi Xie, Qiulian Wu, Stephen C. Mack, Yu Shi, Leo J. Y. Kim, et al. “Purine synthesis promotes maintenance of brain tumor initiating cells in glioma..” Nature Neuroscience 20, no. 5 (May 2017): 661–73. https://doi.org/10.1038/nn.4537.
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  - Gao, Xia, Michael A. Reid, Mei Kong, and Jason W. Locasale. “Metabolic interactions with cancer epigenetics..” Molecular Aspects of Medicine 54 (April 2017): 50–57. https://doi.org/10.1016/j.mam.2016.09.001.
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  - Liu, Xiaojing, and Jason W. Locasale. “Metabolomics: A Primer..” Trends in Biochemical Sciences 42, no. 4 (April 2017): 274–84. https://doi.org/10.1016/j.tibs.2017.01.004.
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  - Cluntun, Ahmad A., Michael J. Lukey, Richard A. Cerione, and Jason W. Locasale. “Glutamine Metabolism in Cancer: Understanding the Heterogeneity..” Trends in Cancer 3, no. 3 (March 2017): 169–80. https://doi.org/10.1016/j.trecan.2017.01.005.
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  - McDonald, Oliver G., Xin Li, Tyler Saunders, Rakel Tryggvadottir, Samantha J. Mentch, Marc O. Warmoes, Anna E. Word, et al. “Epigenomic reprogramming during pancreatic cancer progression links anabolic glucose metabolism to distant metastasis..” Nature Genetics 49, no. 3 (March 2017): 367–76. https://doi.org/10.1038/ng.3753.
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  - Dai, Ziwei, and Jason W. Locasale. “Metabolic pattern formation in the tumor microenvironment..” Molecular Systems Biology 13, no. 2 (February 9, 2017). https://doi.org/10.15252/msb.20167518.
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  - Mattocks, Dwight A. L., Samantha J. Mentch, Jelena Shneyder, Gene P. Ables, Dongxiao Sun, John P. Richie, Jason W. Locasale, and Sailendra N. Nichenametla. “Short term methionine restriction increases hepatic global DNA methylation in adult but not young male C57BL/6J mice..” Experimental Gerontology 88 (February 2017): 1–8. https://doi.org/10.1016/j.exger.2016.12.003.
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  - Mehrmohamadi, Mahya, Seong Ho Jeong, and Jason W. Locasale. “Molecular features that predict the response to antimetabolite chemotherapies..” Cancer & Metabolism 5 (January 2017). https://doi.org/10.1186/s40170-017-0170-3.
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  - Salerno, Stephen, Mahya Mehrmohamadi, Maria V. Liberti, Muting Wan, Martin T. Wells, James G. Booth, and Jason W. Locasale. “RRmix: A method for simultaneous batch effect correction and analysis of metabolomics data in the absence of internal standards..” Plos One 12, no. 6 (January 2017). https://doi.org/10.1371/journal.pone.0179530.
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  - Wang, Qian, Maria V. Liberti, Pei Liu, Xiaobing Deng, Ying Liu, Jason W. Locasale, and Luhua Lai. “Rational Design of Selective Allosteric Inhibitors of PHGDH and Serine Synthesis with Anti-tumor Activity..” Cell Chemical Biology 24, no. 1 (January 2017): 55–65. https://doi.org/10.1016/j.chembiol.2016.11.013.
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  - Mehrmohamadi, Mahya, Lucas K. Mentch, Andrew G. Clark, and Jason W. Locasale. “Integrative modelling of tumour DNA methylation quantifies the contribution of metabolism..” Nature Communications 7 (December 14, 2016). https://doi.org/10.1038/ncomms13666.
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  - Gao, Xia, and Jason W. Locasale. “Serine Metabolism Links Tumor Suppression to the Epigenetic Landscape..” Cell Metabolism 24, no. 6 (December 2016): 777–79. https://doi.org/10.1016/j.cmet.2016.11.012.
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  - Gerriets, Valerie A., Rigel J. Kishton, Marc O. Johnson, Sivan Cohen, Peter J. Siska, Amanda G. Nichols, Marc O. Warmoes, et al. “Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression..” Nature Immunology 17, no. 12 (December 2016): 1459–66. https://doi.org/10.1038/ni.3577.
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  - Liu, Xiaojing, Iris L. Romero, Lacey M. Litchfield, Ernst Lengyel, and Jason W. Locasale. “Metformin Targets Central Carbon Metabolism and Reveals Mitochondrial Requirements in Human Cancers..” Cell Metabolism 24, no. 5 (November 2016): 728–39. https://doi.org/10.1016/j.cmet.2016.09.005.
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  - Pan, Min, Michael A. Reid, Xazmin H. Lowman, Rajan P. Kulkarni, Thai Q. Tran, Xiaojing Liu, Ying Yang, et al. “Regional glutamine deficiency in tumours promotes dedifferentiation through inhibition of histone demethylation..” Nature Cell Biology 18, no. 10 (October 2016): 1090–1101. https://doi.org/10.1038/ncb3410.
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  - Zeng, Hu, Sivan Cohen, Cliff Guy, Sharad Shrestha, Geoffrey Neale, Scott A. Brown, Caryn Cloer, et al. “mTORC1 and mTORC2 Kinase Signaling and Glucose Metabolism Drive Follicular Helper T Cell Differentiation..” Immunity 45, no. 3 (September 13, 2016): 540–54. https://doi.org/10.1016/j.immuni.2016.08.017.
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  - Dai, Ziwei, Alexander A. Shestov, Luhua Lai, and Jason W. Locasale. “A Flux Balance of Glucose Metabolism Clarifies the Requirements of the Warburg Effect..” Biophysical Journal 111, no. 5 (September 2016): 1088–1100. https://doi.org/10.1016/j.bpj.2016.07.028.
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  - Reid, Michael A., Xazmin H. Lowman, Min Pan, Thai Q. Tran, Marc O. Warmoes, Mari B. Ishak Gabra, Ying Yang, Jason W. Locasale, and Mei Kong. “IKKβ promotes metabolic adaptation to glutamine deprivation via phosphorylation and inhibition of PFKFB3..” Genes & Development 30, no. 16 (August 2016): 1837–51. https://doi.org/10.1101/gad.287235.116.
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  - Liberti, Maria V., and Jason W. Locasale. “Metabolism: A new layer of glycolysis..” Nature Chemical Biology 12, no. 8 (July 2016): 577–78. https://doi.org/10.1038/nchembio.2133.
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  - Ser, Zheng, Xia Gao, Christelle Johnson, Mahya Mehrmohamadi, Xiaojing Liu, Siqi Li, and Jason W. Locasale. “Targeting One Carbon Metabolism with an Antimetabolite Disrupts Pyrimidine Homeostasis and Induces Nucleotide Overflow..” Cell Reports 15, no. 11 (June 2, 2016): 2367–76. https://doi.org/10.1016/j.celrep.2016.05.035.
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  - Torrano, Veronica, Lorea Valcarcel-Jimenez, Ana Rosa Cortazar, Xiaojing Liu, Jelena Urosevic, Mireia Castillo-Martin, Sonia Fernández-Ruiz, et al. “The metabolic co-regulator PGC1α suppresses prostate cancer metastasis..” Nature Cell Biology 18, no. 6 (June 2016): 645–56. https://doi.org/10.1038/ncb3357.
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  - Park, Sunghee, Ching-Yi Chang, Rachid Safi, Xiaojing Liu, Robert Baldi, Jeff S. Jasper, Grace R. Anderson, et al. “ERRα-Regulated Lactate Metabolism Contributes to Resistance to Targeted Therapies in Breast Cancer..” Cell Rep 15, no. 2 (April 12, 2016): 323–35. https://doi.org/10.1016/j.celrep.2016.03.026.
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  - Sadhukhan, Sushabhan, Xiaojing Liu, Dongryeol Ryu, Ornella D. Nelson, John A. Stupinski, Zhi Li, Wei Chen, et al. “Metabolomics-assisted proteomics identifies succinylation and SIRT5 as important regulators of cardiac function..” Proceedings of the National Academy of Sciences of the United States of America 113, no. 16 (April 5, 2016): 4320–25. https://doi.org/10.1073/pnas.1519858113.
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  - Kishton, Rigel J., Carson E. Barnes, Amanda G. Nichols, Sivan Cohen, Valerie A. Gerriets, Peter J. Siska, Andrew N. Macintyre, et al. “AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival..” Cell Metabolism 23, no. 4 (April 2016): 649–62. https://doi.org/10.1016/j.cmet.2016.03.008.
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  - Jurkowska, Halina, Julie Niewiadomski, Lawrence L. Hirschberger, Heather B. Roman, Kevin M. Mazor, Xiaojing Liu, Jason W. Locasale, Eunkyue Park, and Martha H. Stipanuk. “Downregulation of hepatic betaine:homocysteine methyltransferase (BHMT) expression in taurine-deficient mice is reversed by taurine supplementation in vivo..” Amino Acids 48, no. 3 (March 2016): 665–76. https://doi.org/10.1007/s00726-015-2108-9.
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  - Liberti, Maria V., and Jason W. Locasale. “The Warburg Effect: How Does it Benefit Cancer Cells?.” Trends in Biochemical Sciences 41, no. 3 (March 2016): 211–18. https://doi.org/10.1016/j.tibs.2015.12.001.
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  - Liberti, Maria V., and Jason W. Locasale. “Correction to: 'The Warburg Effect: How Does it Benefit Cancer Cells?': [Trends in Biochemical Sciences, 41 (2016) 211]..” Trends in Biochemical Sciences 41, no. 3 (March 2016). https://doi.org/10.1016/j.tibs.2016.01.004.
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  - Chiyoda, Tatsuyuki, Xiaojing Liu, Ernst Lengyel, Jason Locasale, and Iris Romero. “Abstract A68: Sphingosine kinase 1 as a mediator and predictor of metformin's protective effect in ovarian cancer..” Other Topics, January 15, 2016. https://doi.org/10.1158/1557-3265.ovca15-a68.
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  - Sumita, Kazutaka, Yu-Hua Lo, Koh Takeuchi, Miki Senda, Satoshi Kofuji, Yoshiki Ikeda, Jumpei Terakawa, et al. “The Lipid Kinase PI5P4Kβ Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis..” Molecular Cell 61, no. 2 (January 7, 2016): 187–98. https://doi.org/10.1016/j.molcel.2015.12.011.
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  - Mentch, Samantha J., and Jason W. Locasale. “One-carbon metabolism and epigenetics: understanding the specificity..” Ann N Y Acad Sci 1363 (January 2016): 91–98. https://doi.org/10.1111/nyas.12956.
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  - Niewiadomski, Julie, James Q. Zhou, Heather B. Roman, Xiaojing Liu, Lawrence L. Hirschberger, Jason W. Locasale, and Martha H. Stipanuk. “Effects of a block in cysteine catabolism on energy balance and fat metabolism in mice..” Annals of the New York Academy of Sciences 1363 (January 2016): 99–115. https://doi.org/10.1111/nyas.13021.
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  - Barker, Brandon E., Narayanan Sadagopan, Yiping Wang, Kieran Smallbone, Christopher R. Myers, Hongwei Xi, Jason W. Locasale, and Zhenglong Gu. “A robust and efficient method for estimating enzyme complex abundance and metabolic flux from expression data..” Computational Biology and Chemistry 59 Pt B (December 2015): 98–112. https://doi.org/10.1016/j.compbiolchem.2015.08.002.
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  - Block, Keith I., Charlotte Gyllenhaal, Leroy Lowe, Amedeo Amedei, ARM Ruhul Amin, Amr Amin, Katia Aquilano, et al. “Designing a broad-spectrum integrative approach for cancer prevention and treatment..” Seminars in Cancer Biology 35 Suppl (December 2015): S276–304. https://doi.org/10.1016/j.semcancer.2015.09.007.
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  - Hirschey, Matthew D., Ralph J. DeBerardinis, Anna Mae E. Diehl, Janice E. Drew, Christian Frezza, Michelle F. Green, Lee W. Jones, et al. “Dysregulated metabolism contributes to oncogenesis..” Seminars in Cancer Biology 35 Suppl (December 2015): S129–50. https://doi.org/10.1016/j.semcancer.2015.10.002.
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  - Colak, Gozde, Olga Pougovkina, Lunzhi Dai, Minjia Tan, Heleen Te Brinke, He Huang, Zhongyi Cheng, et al. “Proteomic and Biochemical Studies of Lysine Malonylation Suggest Its Malonic Aciduria-associated Regulatory Role in Mitochondrial Function and Fatty Acid Oxidation..” Mol Cell Proteomics 14, no. 11 (November 2015): 3056–71. https://doi.org/10.1074/mcp.M115.048850.
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  - Mentch, Samantha J., Mahya Mehrmohamadi, Lei Huang, Xiaojing Liu, Diwakar Gupta, Dwight Mattocks, Paola Gómez Padilla, et al. “Histone Methylation Dynamics and Gene Regulation Occur through the Sensing of One-Carbon Metabolism..” Cell Metabolism 22, no. 5 (November 2015): 861–73. https://doi.org/10.1016/j.cmet.2015.08.024.
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  - Douris, Nicholas, Tamar Melman, Jordan M. Pecherer, Pavlos Pissios, Jeffrey S. Flier, Lewis C. Cantley, Jason W. Locasale, and Eleftheria Maratos-Flier. “Adaptive changes in amino acid metabolism permit normal longevity in mice consuming a low-carbohydrate ketogenic diet..” Biochimica Et Biophysica Acta 1852, no. 10 Pt A (October 2015): 2056–65. https://doi.org/10.1016/j.bbadis.2015.07.009.
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  - Mehrmohamadi, Mahya, and Jason W. Locasale. “Context dependent utilization of serine in cancer..” Molecular & Cellular Oncology 2, no. 4 (October 2015). https://doi.org/10.1080/23723556.2014.996418.
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  - Chourasia, Aparajita H., Kristin Tracy, Casey Frankenberger, Michelle L. Boland, Marina N. Sharifi, Lauren E. Drake, Joseph R. Sachleben, et al. “Mitophagy defects arising from BNip3 loss promote mammary tumor progression to metastasis..” Embo Reports 16, no. 9 (September 2015): 1145–63. https://doi.org/10.15252/embr.201540759.
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  - Ho, Ping-Chih, Jessica Dauz Bihuniak, Andrew N. Macintyre, Matthew Staron, Xiaojing Liu, Robert Amezquita, Yao-Chen Tsui, et al. “Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses..” Cell 162, no. 6 (September 2015): 1217–28. https://doi.org/10.1016/j.cell.2015.08.012.
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  - Buescher, Joerg M., Maciek R. Antoniewicz, Laszlo G. Boros, Shawn C. Burgess, Henri Brunengraber, Clary B. Clish, Ralph J. DeBerardinis, et al. “A roadmap for interpreting (13)C metabolite labeling patterns from cells..” Current Opinion in Biotechnology 34 (August 2015): 189–201. https://doi.org/10.1016/j.copbio.2015.02.003.
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  - Simões, Rui V., Inna S. Serganova, Natalia Kruchevsky, Avigdor Leftin, Alexander A. Shestov, Howard T. Thaler, George Sukenick, et al. “Metabolic plasticity of metastatic breast cancer cells: adaptation to changes in the microenvironment..” Neoplasia (New York, N.Y.) 17, no. 8 (August 2015): 671–84. https://doi.org/10.1016/j.neo.2015.08.005.
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  - Liu, Xiaojing, Sushabhan Sadhukhan, Shengyi Sun, Gregory R. Wagner, Matthew D. Hirschey, Ling Qi, Hening Lin, and Jason W. Locasale. “High-Resolution Metabolomics with Acyl-CoA Profiling Reveals Widespread Remodeling in Response to Diet..” Molecular & Cellular Proteomics : Mcp 14, no. 6 (June 2015): 1489–1500. https://doi.org/10.1074/mcp.M114.044859.
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  - Ser, Zheng, Xiaojing Liu, Ngoc Nu Tang, and Jason W. Locasale. “Extraction parameters for metabolomics from cultured cells..” Analytical Biochemistry 475 (April 2015): 22–28. https://doi.org/10.1016/j.ab.2015.01.003.
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  - Chen, Jinyu, Ho-Jeong Lee, Xuefeng Wu, Lei Huo, Sun-Jin Kim, Lei Xu, Yan Wang, et al. “Gain of glucose-independent growth upon metastasis of breast cancer cells to the brain..” Cancer Research 75, no. 3 (February 2015): 554–65. https://doi.org/10.1158/0008-5472.CAN-14-2268.
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  - Madhukar, Neel S., Marc O. Warmoes, and Jason W. Locasale. “Organization of enzyme concentration across the metabolic network in cancer cells..” Plos One 10, no. 1 (January 26, 2015). https://doi.org/10.1371/journal.pone.0117131.
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  - Cluntun, Ahmad A., He Huang, Lunzhi Dai, Xiaojing Liu, Yingming Zhao, and Jason W. Locasale. “The rate of glycolysis quantitatively mediates specific histone acetylation sites..” Cancer & Metabolism 3 (January 2015). https://doi.org/10.1186/s40170-015-0135-3.
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  - Crowe, Kristi M., David Allison, and David Bioactive Food Components Conference Speakers. “Evaluating bioactive food components in obesity and cancer prevention..” Critical Reviews in Food Science and Nutrition 55, no. 5 (January 2015): 732–34. https://doi.org/10.1080/10408398.2013.878305.
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  - Gerriets, Valerie A., Rigel J. Kishton, Amanda G. Nichols, Andrew N. Macintyre, Makoto Inoue, Olga Ilkayeva, Peter S. Winter, et al. “Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation..” The Journal of Clinical Investigation 125, no. 1 (January 2015): 194–207. https://doi.org/10.1172/JCI76012.
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  - Johnson, Christelle, Marc O. Warmoes, Xiling Shen, and Jason W. Locasale. “Epigenetics and cancer metabolism..” Cancer Letters 356, no. 2 Pt A (January 2015): 309–14. https://doi.org/10.1016/j.canlet.2013.09.043.
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  - Huang, Lei, Dongsung Kim, Xiaojing Liu, Christopher R. Myers, and Jason W. Locasale. “Estimating relative changes of metabolic fluxes..” Plos Computational Biology 10, no. 11 (November 20, 2014). https://doi.org/10.1371/journal.pcbi.1003958.
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  - Liu, T., R. J. Kishton, A. N. Macintyre, V. A. Gerriets, H. Xiang, X. Liu, E. D. Abel, D. Rizzieri, J. W. Locasale, and J. C. Rathmell. “Glucose transporter 1-mediated glucose uptake is limiting for B-cell acute lymphoblastic leukemia anabolic metabolism and resistance to apoptosis..” Cell Death & Disease 5, no. 11 (November 6, 2014). https://doi.org/10.1038/cddis.2014.493.
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  - Mehrmohamadi, Mahya, Xiaojing Liu, Alexander A. Shestov, and Jason W. Locasale. “Characterization of the usage of the serine metabolic network in human cancer..” Cell Reports 9, no. 4 (November 6, 2014): 1507–19. https://doi.org/10.1016/j.celrep.2014.10.026.
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  - Warmoes, Marc O., and Jason W. Locasale. “Heterogeneity of glycolysis in cancers and therapeutic opportunities..” Biochem Pharmacol 92, no. 1 (November 1, 2014): 12–21. https://doi.org/10.1016/j.bcp.2014.07.019.
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  - Liu, T., R. J. Kishton, A. N. Macintyre, V. A. Gerriets, H. Xiang, X. Liu, E. D. Abel, D. Rizzieri, J. W. Locasale, and J. C. Rathmell. “Glucose transporter 1-mediated glucose uptake is limiting for B-cell acute lymphoblastic leukemia anabolic metabolism and resistance to apoptosis..” Cell Death & Disease 5 (October 16, 2014). https://doi.org/10.1038/cddis.2014.431.
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  - Shestov, Alexander A., Xiaojing Liu, Zheng Ser, Ahmad A. Cluntun, Yin P. Hung, Lei Huang, Dongsung Kim, et al. “Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step..” Elife 3 (July 9, 2014). https://doi.org/10.7554/eLife.03342.
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  - Shestov, Alexander A., Xiaojing Liu, Zheng Ser, Ahmad A. Cluntun, Yin P. Hung, Lei Huang, Dongsung Kim, et al. “Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step.” Elife 3 (July 9, 2014). https://doi.org/10.7554/eLife.03342.
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  - Liu, Xiaojing, Zheng Ser, Ahmad A. Cluntun, Samantha J. Mentch, and Jason W. Locasale. “A strategy for sensitive, large scale quantitative metabolomics..” Journal of Visualized Experiments : Jove, no. 87 (May 27, 2014). https://doi.org/10.3791/51358.
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  - Dasgupta, Tathagata, David H. Croll, Jeremy A. Owen, Matthew G. Vander Heiden, Jason W. Locasale, Uri Alon, Lewis C. Cantley, and Jeremy Gunawardena. “A fundamental trade-off in covalent switching and its circumvention by enzyme bifunctionality in glucose homeostasis..” J Biol Chem 289, no. 19 (May 9, 2014): 13010–25. https://doi.org/10.1074/jbc.M113.546515.
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  - Sun, S., G. Shi, X. Han, A. B. Francisco, Y. Ji, N. Mendonça, X. Liu, et al. “Erratum: Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation, endoplasmic reticulum homeostasis, and survival (Proceedings of the National Academy of Sciences of the United States of America (2014) 111, 5, (E582-E591) doi:10.1073/pnas.1318114111).” Proceedings of the National Academy of Sciences of the United States of America 111, no. 16 (April 22, 2014). https://doi.org/10.1073/pnas.1405563111.
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  - Liu, Xiaojing, Zheng Ser, and Jason W. Locasale. “Development and quantitative evaluation of a high-resolution metabolomics technology..” Anal Chem 86, no. 4 (February 18, 2014): 2175–84. https://doi.org/10.1021/ac403845u.
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  - Sun, Shengyi, Guojun Shi, Xuemei Han, Adam B. Francisco, Yewei Ji, Nuno Mendonça, Xiaojing Liu, et al. “Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation, endoplasmic reticulum homeostasis, and survival..” Proc Natl Acad Sci U S A 111, no. 5 (February 4, 2014): E582–91. https://doi.org/10.1073/pnas.1318114111.
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  - Chen, Kai-Yuan, Xiaojing Liu, Pengcheng Bu, Chieh-Sheng Lin, Nikolai Rakhilin, Jason W. Locasale, and Xiling Shen. “A metabolic signature of colon cancer initiating cells..” Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual Conference 2014 (January 2014): 4759–62. https://doi.org/10.1109/EMBC.2014.6944688.
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  - Johnson, Christelle, Kai-Yuan Chen, Xiaojing Liu, Pengcheng Bu, Jason Locasale, and Xiling Shen. “A metabolic signature of colon cancer initiating cells..” Cancer & Metabolism 2, no. Suppl 1 (January 2014): P32–P32. https://doi.org/10.1186/2049-3002-2-S1-P32.
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  - Liu, T., R. J. Kishton, A. N. Macintyre, V. A. Gerriets, H. Xiang, X. Liu, E. D. Abel, D. Rizzieri, J. W. Locasale, and J. C. Rathmell. “Glucose transporter 1-mediated glucose uptake is limiting for B-cell acute lymphoblastic leukemia anabolic metabolism and resistance to apoptosis..” Cell Death & Disease 5 (2014). https://doi.org/10.1038/cddis.2014.493.
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  - Parkhitko, Andrey A., Carmen Priolo, Jonathan L. Coloff, Jihye Yun, Julia J. Wu, Kenji Mizumura, Wenping Xu, et al. “Autophagy-dependent metabolic reprogramming sensitizes TSC2-deficient cells to the antimetabolite 6-aminonicotinamide..” Molecular Cancer Research : Mcr 12, no. 1 (January 2014): 48–57. https://doi.org/10.1158/1541-7786.MCR-13-0258-T.
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  - Shestov, Alexander A., Brandon Barker, Zhenglong Gu, and Jason W. Locasale. “Computational approaches for understanding energy metabolism..” Wiley Interdisciplinary Reviews. Systems Biology and Medicine 5, no. 6 (November 2013): 733–50. https://doi.org/10.1002/wsbm.1238.
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  - Locasale, Jason W. “Serine, glycine and one-carbon units: cancer metabolism in full circle..” Nat Rev Cancer 13, no. 8 (August 2013): 572–83. https://doi.org/10.1038/nrc3557.
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  - Hu, Jie, Jason W. Locasale, Jason H. Bielas, Jacintha O’Sullivan, Kieran Sheahan, Lewis C. Cantley, Matthew G. Vander Heiden, and Dennis Vitkup. “Heterogeneity of tumor-induced gene expression changes in the human metabolic network..” Nature Biotechnology 31, no. 6 (June 2013): 522–29. https://doi.org/10.1038/nbt.2530.
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  - Shyh-Chang, Ng, Jason W. Locasale, Costas A. Lyssiotis, Yuxiang Zheng, Ren Yi Teo, Sutheera Ratanasirintrawoot, Jin Zhang, et al. “Influence of threonine metabolism on S-adenosylmethionine and histone methylation..” Science 339, no. 6116 (January 11, 2013): 222–26. https://doi.org/10.1126/science.1226603.
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  - Baker, Rachael, Steven M. Lewis, Atsuo T. Sasaki, Emily M. Wilkerson, Jason W. Locasale, Lewis C. Cantley, Brian Kuhlman, Henrik G. Dohlman, and Sharon L. Campbell. “Site-specific monoubiquitination activates Ras by impeding GTPase-activating protein function..” Nature Structural & Molecular Biology 20, no. 1 (January 2013): 46–52. https://doi.org/10.1038/nsmb.2430.
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  - Locasale, Jason W. “The consequences of enhanced cell-autonomous glucose metabolism..” Trends in Endocrinology and Metabolism: Tem 23, no. 11 (November 2012): 545–51. https://doi.org/10.1016/j.tem.2012.07.005.
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  - Locasale, Jason W., Tamar Melman, Susan Song, Xuemei Yang, Kenneth D. Swanson, Lewis C. Cantley, Eric T. Wong, and John M. Asara. “Metabolomics of human cerebrospinal fluid identifies signatures of malignant glioma..” Molecular & Cellular Proteomics : Mcp 11, no. 6 (June 2012). https://doi.org/10.1074/mcp.M111.014688.
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  - Ying, Haoqiang, Alec C. Kimmelman, Costas A. Lyssiotis, Sujun Hua, Gerald C. Chu, Eliot Fletcher-Sananikone, Jason W. Locasale, et al. “Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism..” Cell 149, no. 3 (April 27, 2012): 656–70. https://doi.org/10.1016/j.cell.2012.01.058.
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  - Lyssiotis, C. A., D. Anastasiou, J. W. Locasale, M. G. Vander Heiden, H. R. Christofk, and L. C. Cantley. “Cellular control mechanisms that regulate pyruvate kinase M2 activity and promote cancer growth.” Biomedical Research 23, no. SPEC. ISSUE (February 23, 2012): 213–17.
  - Locasale, J. W., T. Melman, S. Song, X. Yang, K. D. Swanson, L. C. Cantley, E. T. Wong, and J. M. Asara. “Metabolomics of human cerebrospinal fluid identifies signatures of malignant glioma..” Molecular & Cellular Proteomics : Mcp 11, no. 6 (2012). https://doi.org/10.1074/mcp.M111.014688.
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  - Locasale, Jason W. “Metabolic rewiring drives resistance to targeted cancer therapy..” Molecular Systems Biology 8 (January 2012). https://doi.org/10.1038/msb.2012.30.
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  - Locasale, Jason W., Alexandra Grassian, Rameen Beroukhim, Matthew Meyerson, Gerhard Wagner, John M. Asara, Joan S. Brugge, Matthew G. Vander Heiden, and Lewis C. Cantley. “Amplification of phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis..” Bmc Proceedings 6, no. Suppl 3 (January 2012): O15–O15. https://doi.org/10.1186/1753-6561-6-S3-O15.
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  - Locasale, Jason W., and Benjamin J. Zeskind. “Maximizing the efficacy of angiogenesis inhibitors..” Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology 30, no. 3 (January 2012): 337–38. https://doi.org/10.1200/jco.2011.38.5435.
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  - Yun, Jihye, Jared L. Johnson, Christin L. Hanigan, and Jason W. Locasale. “Interactions between epigenetics and metabolism in cancers..” Frontiers in Oncology 2 (January 2012). https://doi.org/10.3389/fonc.2012.00163.
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  - Shyh-Chang, Ng, Yuxiang Zheng, Jason W. Locasale, and Lewis C. Cantley. “Human pluripotent stem cells decouple respiration from energy production..” The Embo Journal 30, no. 24 (December 14, 2011): 4851–52. https://doi.org/10.1038/emboj.2011.436.
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  - Locasale, Jason W., and Benjamin Zeskind. “IL-6 and ovarian cancer--letter..” Clinical Cancer Research : An Official Journal of the American Association for Cancer Research 17, no. 24 (December 6, 2011). https://doi.org/10.1158/1078-0432.ccr-11-2170.
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  - Anastasiou, Dimitrios, George Poulogiannis, John M. Asara, Matthew B. Boxer, Jian-kang Jiang, Min Shen, Gary Bellinger, et al. “Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses..” Science 334, no. 6060 (December 2, 2011): 1278–83. https://doi.org/10.1126/science.1211485.
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  - Mullarky, Edouard, Katherine R. Mattaini, Matthew G. Vander Heiden, Lewis C. Cantley, and Jason W. Locasale. “PHGDH amplification and altered glucose metabolism in human melanoma..” Pigment Cell & Melanoma Research 24, no. 6 (December 2011): 1112–15. https://doi.org/10.1111/j.1755-148x.2011.00919.x.
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  - Locasale, Jason W., and Lewis C. Cantley. “Genetic selection for enhanced serine metabolism in cancer development..” Cell Cycle (Georgetown, Tex.) 10, no. 22 (November 15, 2011): 3812–13. https://doi.org/10.4161/cc.10.22.18224.
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  - Locasale, Jason W., Tamar Melman, Susan S. Song, Xuemei Yang, Kenneth D. Swanson, Lewis C. Cantley, John M. Asara, and Eric T. Wong. “METABOLOMICS PROFILING OF PATIENT CEREBROSPINAL FLUID IDENTIFIES SIGNATURES OF MALIGNANT GLIOMA.” Neuro Oncology 13 (November 1, 2011): 69–69.
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  - “METABOLIC PATHWAYS..” Neuro Oncology 13, no. Suppl 3 (November 2011): iii69–72. https://doi.org/10.1093/neuonc/nor153.
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  - Gao, Daming, Hiroyuki Inuzuka, Meng-Kwang Marcus Tan, Hidefumi Fukushima, Jason W. Locasale, Pengda Liu, Lixin Wan, et al. “mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR..” Molecular Cell 44, no. 2 (October 2011): 290–303. https://doi.org/10.1016/j.molcel.2011.08.030.
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  - Locasale, Jason W., and Lewis C. Cantley. “Metabolic flux and the regulation of mammalian cell growth..” Cell Metabolism 14, no. 4 (October 2011): 443–51. https://doi.org/10.1016/j.cmet.2011.07.014.
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  - Yi, Caroline H., Heling Pan, Jan Seebacher, Il-Ho Jang, Sven G. Hyberts, Gregory J. Heffron, Matthew G. Vander Heiden, et al. “Metabolic regulation of protein N-alpha-acetylation by Bcl-xL promotes cell survival..” Cell 146, no. 4 (August 2011): 607–20. https://doi.org/10.1016/j.cell.2011.06.050.
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  - Locasale, Jason W., Alexandra R. Grassian, Tamar Melman, Costas A. Lyssiotis, Katherine R. Mattaini, Adam J. Bass, Gregory Heffron, et al. “Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis..” Nat Genet 43, no. 9 (July 31, 2011): 869–74. https://doi.org/10.1038/ng.890.
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  - CANTLEY LEWIS C, J. C., J. C. VANDER HEIDEN MATTHEW, J. C. LOCASALE JASON, and J. C. SHARFI HADAR. “METHODS AND COMPOSITIONS FOR THE DIAGNOSIS AND TREATMENT OF CELLULAR PROLIFERATIVE DISORDERS,” May 26, 2011.
  - Yang, Xuemei, Jason Locasale, Rami Rahal, Susanne Breitkopf, Matthew VanderHeiden, Dimitrios Spentzos, Chin-Lee Wu, et al. “Abstract LB-255: A mass spectrometry platform to quantitatively profile cancer cell metabolism from cells, tumors, and fixed tissue.” Cancer Research 71, no. 8 Supplement (April 15, 2011). https://doi.org/10.1158/1538-7445.am2011-lb-255.
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  - Sasaki, Atsuo T., Arkaitz Carracedo, Jason W. Locasale, Dimitrios Anastasiou, Koh Takeuchi, Emily Rose Kahoud, Sasson Haviv, John M. Asara, Pier Paolo Pandolfi, and Lewis C. Cantley. “Ubiquitination of K-Ras enhances activation and facilitates binding to select downstream effectors..” Science Signaling 4, no. 163 (March 8, 2011). https://doi.org/10.1126/scisignal.2001518.
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  - Vander Heiden, M. G., S. Y. Lunt, T. L. Dayton, B. P. Fiske, W. J. Israelsen, K. R. Mattaini, N. I. Vokes, et al. “Metabolic pathway alterations that support cell proliferation..” Cold Spring Harb Symp Quant Biol 76 (2011): 325–34. https://doi.org/10.1101/sqb.2012.76.010900.
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  - Locasale, Jason W., Matthew G. Vander Heiden, and Lewis C. Cantley. “Rewiring of glycolysis in cancer cell metabolism..” Cell Cycle (Georgetown, Tex.) 9, no. 21 (November 7, 2010). https://doi.org/10.4161/cc.9.21.13925.
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  - Vander Heiden, Matthew G., Jason W. Locasale, Kenneth D. Swanson, Hadar Sharfi, Greg J. Heffron, Daniel Amador-Noguez, Heather R. Christofk, et al. “Evidence for an alternative glycolytic pathway in rapidly proliferating cells..” Science 329, no. 5998 (September 17, 2010): 1492–99. https://doi.org/10.1126/science.1188015.
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  - Yang, X., R. Rahal, J. Locasale, S. Song, L. Cantley, E. Wong, N. Perrimon, M. Vander Heiden, and J. Asara. “A Mass Spectrometry Platform to Quantitatively Profile Cancer Cell Metabolism from Cell Lines to Tissues..” Journal of Biomolecular Techniques : Jbt 21, no. 3 Suppl (September 2010): S39–40.
  - Prisic, Sladjana, Selasi Dankwa, Daniel Schwartz, Michael F. Chou, Jason W. Locasale, Choong-Min Kang, Guy Bemis, George M. Church, Hanno Steen, and Robert N. Husson. “Extensive phosphorylation with overlapping specificity by Mycobacterium tuberculosis serine/threonine protein kinases..” Proceedings of the National Academy of Sciences of the United States of America 107, no. 16 (April 5, 2010): 7521–26. https://doi.org/10.1073/pnas.0913482107.
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  - Locasale, Jason W., and Lewis C. Cantley. “Altered metabolism in cancer..” Bmc Biology 8 (January 2010). https://doi.org/10.1186/1741-7007-8-88.
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  - Locasale, Jason W., Lewis C. Cantley, and Matthew G. Vander Heiden. “Cancer's insatiable appetite..” Nature Biotechnology 27, no. 10 (October 2009): 916–17. https://doi.org/10.1038/nbt1009-916.
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  - Locasale, Jason W., and Alejandro Wolf-Yadlin. “Maximum entropy reconstructions of dynamic signaling networks from quantitative proteomics data..” Plos One 4, no. 8 (August 26, 2009). https://doi.org/10.1371/journal.pone.0006522.
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  - Locasale, Jason W., Andrew A. Napoli, Shengfeng Chen, Helen M. Berman, and Catherine L. Lawson. “Signatures of protein-DNA recognition in free DNA binding sites..” Journal of Molecular Biology 386, no. 4 (March 2009): 1054–65. https://doi.org/10.1016/j.jmb.2009.01.007.
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  - Locasale, Jason W. “Signal duration and the time scale dependence of signal integration in biochemical pathways..” Bmc Systems Biology 2 (December 17, 2008). https://doi.org/10.1186/1752-0509-2-108.
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  - Locasale, Jason W. “Three-state kinetic mechanism for scaffold-mediated signal transduction..” Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics 78, no. 5 Pt 1 (November 21, 2008). https://doi.org/10.1103/PhysRevE.78.051921.
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  - Locasale, Jason W., and Arup K. Chakraborty. “Regulation of signal duration and the statistical dynamics of kinase activation by scaffold proteins..” Plos Computational Biology 4, no. 6 (June 27, 2008). https://doi.org/10.1371/journal.pcbi.1000099.
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  - Locasale, Jason W., and Arup K. Chakraborty. “Importance of signal duration and the time scale dependence of signal integration in biochemical networks.” Faseb Journal 22 (April 1, 2008).
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  - Locasale, Jason W. “Allovalency revisited: an analysis of multisite phosphorylation and substrate rebinding..” The Journal of Chemical Physics 128, no. 11 (March 2008). https://doi.org/10.1063/1.2841124.
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  - Locasale, Jason W. “Scaffold proteins tune the regulatory properties of protein kinase cascades.” Abstracts of Papers of the American Chemical Society 234 (August 19, 2007).
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  - Locasale, Jason W., Andrey S. Shaw, and Arup K. Chakraborty. “Scaffold proteins confer diverse regulatory properties to protein kinase cascades..” Proceedings of the National Academy of Sciences of the United States of America 104, no. 33 (August 8, 2007): 13307–12. https://doi.org/10.1073/pnas.0706311104.
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  - Čemerski, S., J. Das, J. Locasale, P. Arnold, E. Giurisato, M. A. Markiewicz, D. Fremont, P. M. Allen, A. K. Chakraborty, and A. S. Shaw. “The Stimulatory Potency of T Cell Antigens Is Influenced by the Formation of the Immunological Synapse.” Immunity 26, no. 3 (March 23, 2007): 345–55. https://doi.org/10.1016/j.immuni.2007.01.013.
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  - Cemerski, Saso, Jayajit Das, Jason Locasale, Phoebe Arnold, Emanuele Giurisato, Mary A. Markiewicz, Daved Fremont, Paul M. Allen, Arup K. Chakraborty, and Andrey S. Shaw. “The stimulatory potency of T cell antigens is influenced by the formation of the immunological synapse..” Immunity 26, no. 3 (March 8, 2007): 345–55. https://doi.org/10.1016/j.immuni.2007.01.013.
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  - Locasale, Jason W. “Computational investigations into the origins of short-term biochemical memory in T cell activation..” Plos One 2, no. 7 (January 2007). https://doi.org/10.1371/journal.pone.0000627.
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- Book Sections
  - Anastasiou, D., J. W. Locasale, and M. G. Vander Heiden. “Cancer metabolism.” In Systems Biology of Cancer, 295–308, 2015. https://doi.org/10.1017/9780511979811.020.
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  - Patnaik, A., J. W. Locasale, and L. C. Cantley. “Cancer cell metabolism.” In Insulin-like Growth Factors and Cancer: From Basic Biology to Therapeutics, 245–61, 2012. https://doi.org/10.1007/978-1-4614-0598-6_13.
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- Conference Papers
  - Garcia, J. N., J. Bagwell, B. Njaine, J. Norman, D. Levic, S. Wopat, S. Miller, et al. “Sheath Cell Invasion and Trans-differentiation Repair Mechanical Damage Caused by Loss of Caveolae in the Zebrafish Notochord..” In Molecular Biology of the Cell, Vol. 28. AMER SOC CELL BIOLOGY, 2017.
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  - Valcarcel, L., V. Torrano, A. R. Cortazar, X. Liu, J. Urosevic, M. Castillo, G. Morciano, et al. “Transcriptional regulation of prostate cancer metabolism.” In European Journal of Cancer, 61:S171–S171. ELSEVIER SCI LTD, 2016.
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  - O-Sullivan, Insug, Zakaria Sibai, Wenwei Zhang, Jason Locasale, Douglas G. Mashek, and Terry G. Unterman. “Fox01 Promotes Glucose Intolerance in Liver-specific Insulin Receptor Knockout (LIRKO) Mice by Regulating ATGL-dependent Lipo lysis and Fatty Acid Oxidation.” In Diabetes, 65:A67–A67. AMER DIABETES ASSOC, 2016.
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  - Liu, Xiaojing, Ernst Lengyel, Iris Romero, and Jason Locasale. “Metformin acts to disrupt mitochondrial-associated metabolic homeostasis in human cancer.” In Abstracts of Papers of the American Chemical Society, Vol. 250. AMER CHEMICAL SOC, 2015.
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  - Romero, Iris L., Xiaojing Liu, Anirban K. Mitra, Ernst Lengyel, and Jason W. Locasale. “Abstract POSTER-TECH-1123: Advancing metformin as therapeutic for ovarian cancer: metabolomic profiling of mouse ovarian tumors identifies metformin-induced global metabolic changes.” In Technologies That Drive Ovarian Cancer Research. American Association for Cancer Research, 2015. https://doi.org/10.1158/1557-3265.ovcasymp14-poster-tech-1123.
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  - Campbell, Sharon L., Rachael Baker, Steven Lewis, Atsuo Sasaki, Emily M. Wilkerson, Jason Locasale, Lewis C. Cantley, Brian Kuhlman, and Henrik Dohlman. “Ras Activity Regulation by Monoubiquitination.” In Faseb Journal, Vol. 27. FEDERATION AMER SOC EXP BIOL, 2013.
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  - Shestov, Alexander, Anthony Mancuso, Jason W. Locasale, and Jerry D. Glickson. “Human melanoma metabolic network analysis with combined 13C NMR/bioreactor technique: testing the Warburg effect.” In Faseb Journal, Vol. 27. FEDERATION AMER SOC EXP BIOL, 2013.
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  - Locasale, Jason W., Arup K. Chakraborty, and Andrey Shaw. “Scaffold proteins confer diverse regulatory properties to protein kinase cascades.” In Faseb Journal, 21:A264–A264. FEDERATION AMER SOC EXP BIOL, 2007.
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  - Castner, E. W., B. J. Lee, E. G. Diken, H. Shirota, M. DeRitter, P. P. Wiewior, and J. W. Locasale. “Friction, dynamics, and length scales in hydrophilic polymers..” In Abstracts of Papers of the American Chemical Society, 225:U446–U446. AMER CHEMICAL SOC, 2003.
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