Jason Locasale | Scholars@Duke

Jason Locasale
Associate Professor of Pharmacology and Cancer Biology

Our research interests are in three interconnected areas: 1) Quantitative and computational biology of metabolism. 2) The role of diet and pharmacological therapeutics in shaping metabolic pathways in health and cancer. 3) The interaction of metabolism and epigenetics. Each of these synergistic areas utilizes the metabolomics technologies we develop along with our expertise in computational and molecular biology.

Current Appointments & Affiliations

Associate Professor of Pharmacology and Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2018
Member of Duke Molecular Physiology Institute, Duke Molecular Physiology Institute, Duke Molecular Physiology Institute 2013
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2015

Contact Information

Background
Education, Training, & Certifications
- Ph.D., Massachusetts Institute of Technology 2008
- B.A., Rutgers University New Brunswick 2003
Duke Appointment History
- Assistant Professor of Pharmacology & Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2015 - 2018
Recognition
In the News
- SEP 17, 2017 Duke Health News
  
  Natural Molecule Appears to Shut Off Cancer Cells Energy Source
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Yang, Y, Ishak Gabra, MB, Hanse, EA, Lowman, XH, Tran, TQ, Li, H, Milman, N, Liu, J, Reid, MA, Locasale, JW, Gil, Z, and Kong, M. "MiR-135 suppresses glycolysis and promotes pancreatic cancer cell adaptation to metabolic stress by targeting phosphofructokinase-1." Nature Communications 10, no. 1 (February 18, 2019): 809-null. Full Text
  - Cao, JY, Poddar, A, Magtanong, L, Lumb, JH, Mileur, TR, Reid, MA, Dovey, CM, Wang, J, Locasale, JW, Stone, E, Cole, SPC, Carette, JE, and Dixon, SJ. "A Genome-wide Haploid Genetic Screen Identifies Regulators of Glutathione Abundance and Ferroptosis Sensitivity." Cell Reports 26, no. 6 (February 2019): 1544-1556.e8. Full Text
  - Freemerman, AJ, Zhao, L, Pingili, AK, Teng, B, Cozzo, AJ, Fuller, AM, Johnson, AR, Milner, JJ, Lim, MF, Galanko, JA, Beck, MA, Bear, JE, Rotty, JD, Bezavada, L, Smallwood, HS, Puchowicz, MA, Liu, J, Locasale, JW, Lee, DP, Bennett, BJ, Abel, ED, Rathmell, JC, and Makowski, L. "Myeloid Slc2a1-Deficient Murine Model Revealed Macrophage Activation and Metabolic Phenotype Are Fueled by GLUT1." Journal of Immunology (Baltimore, Md. : 1950) 202, no. 4 (February 2019): 1265-1286. Full Text
  - Hart, PC, Chiyoda, T, Liu, X, Weigert, M, Curtis, M, Chiang, C-Y, Loth, R, Lastra, R, McGregor, SM, Locasale, JW, Lengyel, E, and Romero, IL. "SPHK1 Is a Novel Target of Metformin in Ovarian Cancer." Molecular Cancer Research : Mcr (January 17, 2019). Full Text
  - Ma, H, Yu, S, Liu, X, Zhang, Y, Fakadej, T, Liu, Z, Yin, C, Shen, W, Locasale, JW, Taylor, JM, Qian, L, and Liu, J. "Lin28a Regulates Pathological Cardiac Hypertrophic Growth through Pck2-Mediated Enhancement of Anabolic Synthesis." Circulation (January 14, 2019). Full Text
  - Daniels, BP, Kofman, SB, Smith, JR, Norris, GT, Snyder, AG, Kolb, JP, Gao, X, Locasale, JW, Martinez, J, Gale, M, Loo, Y-M, and Oberst, A. "The Nucleotide Sensor ZBP1 and Kinase RIPK3 Induce the Enzyme IRG1 to Promote an Antiviral Metabolic State in Neurons." Immunity 50, no. 1 (January 8, 2019): 64-76.e4. Full Text
  - May, JL, Kouri, FM, Hurley, LA, Liu, J, Tommasini-Ghelfi, S, Ji, Y, Gao, P, Calvert, AE, Lee, A, Chandel, NS, Davuluri, RV, Horbinski, CM, Locasale, JW, and Stegh, AH. "IDH3α regulates one-carbon metabolism in glioblastoma." Science Advances 5, no. 1 (January 2, 2019): eaat0456-null. Full Text
  - Curtis, M, Kenny, HA, Ashcroft, B, Mukherjee, A, Johnson, A, Zhang, Y, Helou, Y, Batlle, R, Liu, X, Gutierrez, N, Gao, X, Yamada, SD, Lastra, R, Montag, A, Ahsan, N, Locasale, JW, Salomon, AR, Nebreda, AR, and Lengyel, E. "Fibroblasts Mobilize Tumor Cell Glycogen to Promote Proliferation and Metastasis." Cell Metabolism 29, no. 1 (January 2019): 141-155.e9. Full Text
  - Gemta, LF, Siska, PJ, Nelson, ME, Gao, X, Liu, X, Locasale, JW, Yagita, H, Slingluff, CL, Hoehn, KL, Rathmell, JC, and Bullock, TNJ. "Impaired enolase 1 glycolytic activity restrains effector functions of tumor-infiltrating CD8+ T cells." Science Immunology 4, no. 31 (January 2019). Full Text
  - Reid, MA, Allen, AE, Liu, S, Liberti, MV, Liu, P, Liu, X, Dai, Z, Gao, X, Wang, Q, Liu, Y, Lai, L, and Locasale, JW. "Serine synthesis through PHGDH coordinates nucleotide levels by maintaining central carbon metabolism." Nature Communications 9, no. 1 (December 21, 2018): 5442-null. Full Text
  - Dai, Z, and Locasale, JW. "Thermodynamic constraints on the regulation of metabolic fluxes." The Journal of Biological Chemistry 293, no. 51 (December 2018): 19725-19739. Full Text
  - Johnson, MO, Wolf, MM, Madden, MZ, Andrejeva, G, Sugiura, A, Contreras, DC, Maseda, D, Liberti, MV, Paz, K, Kishton, RJ, Johnson, ME, de Cubas, AA, Wu, P, Li, G, Zhang, Y, Newcomb, DC, Wells, AD, Restifo, NP, Rathmell, WK, Locasale, JW, Davila, ML, Blazar, BR, and Rathmell, JC. "Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism." Cell 175, no. 7 (December 2018): 1780-1795.e19. Full Text
  - Sanderson, SM, and Locasale, JW. "Revisiting the Warburg Effect: Some Tumors Hold Their Breath." Cell Metabolism 28, no. 5 (November 2018): 669-670. Full Text
  - Stone, OA, El-Brolosy, M, Wilhelm, K, Liu, X, Romão, AM, Grillo, E, Lai, JKH, Günther, S, Jeratsch, S, Kuenne, C, Lee, I-C, Braun, T, Santoro, MM, Locasale, JW, Potente, M, and Stainier, DYR. "Loss of pyruvate kinase M2 limits growth and triggers innate immune signaling in endothelial cells." Nature Communications 9, no. 1 (October 9, 2018): 4077-null. Full Text
  - Liu, X, Cooper, DE, Cluntun, AA, Warmoes, MO, Zhao, S, Reid, MA, Liu, J, Lund, PJ, Lopes, M, Garcia, BA, Wellen, KE, Kirsch, DG, and Locasale, JW. "Acetate Production from Glucose and Coupling to Mitochondrial Metabolism in Mammals." Cell 175, no. 2 (October 2018): 502-513.e13. Full Text
  - Bechard, ME, Word, AE, Tran, AV, Liu, X, Locasale, JW, and McDonald, OG. "Pentose conversions support the tumorigenesis of pancreatic cancer distant metastases." Oncogene 37, no. 38 (September 2018): 5248-5256. Full Text
  - Gamble, LJ, Frye, CW, Hansen, CM, Locasale, JW, Liu, X, Davis, MS, and Wakshlag, JJ. "Serum metabolomics of Alaskan sled dogs during endurance racing." Comparative Exercise Physiology 14, no. 3 (September 1, 2018): 149-159. Full Text
  - Hershberger, KA, Abraham, DM, Liu, J, Locasale, JW, Grimsrud, PA, and Hirschey, MD. "Ablation of Sirtuin5 in the postnatal mouse heart results in protein succinylation and normal survival in response to chronic pressure overload." The Journal of Biological Chemistry 293, no. 27 (July 2018): 10630-10645. Full Text
  - Dai, Z, and Locasale, J. "Thermodynamic constraints on the regulation of metabolic fluxes." (June 7, 2018). Full Text
  - Huang, H, Tang, S, Ji, M, Tang, Z, Shimada, M, Liu, X, Qi, S, Locasale, JW, Roeder, RG, Zhao, Y, and Li, X. "p300-Mediated Lysine 2-Hydroxyisobutyrylation Regulates Glycolysis." Molecular Cell 70, no. 5 (June 7, 2018): 984-null. Full Text
  - Chapman, NM, Zeng, H, Nguyen, T-LM, Wang, Y, Vogel, P, Dhungana, Y, Liu, X, Neale, G, Locasale, JW, and Chi, H. "mTOR coordinates transcriptional programs and mitochondrial metabolism of activated Treg subsets to protect tissue homeostasis." Nature Communications 9, no. 1 (May 29, 2018): 2095-null. Full Text
  - Dai, Z, Mentch, SJ, Gao, X, Nichenametla, SN, and Locasale, JW. "Methionine metabolism influences genomic architecture and gene expression through H3K4me3 peak width." Nature Communications 9, no. 1 (May 16, 2018): 1955-null. Full Text
  - Sanderson, S, Mikhael, P, Dai, Z, and Locasale, J. "Environmental factors shape methionine metabolism in p16/MTAP deleted cells." (May 2, 2018). Full Text
  - Huang, H, Tang, S, Ji, M, Tang, Z, Shimada, M, Liu, X, Qi, S, Locasale, JW, Roeder, RG, Zhao, Y, and Li, X. "p300-Mediated Lysine 2-Hydroxyisobutyrylation Regulates Glycolysis." Molecular Cell 70, no. 4 (May 2018): 663-678.e6. Full Text
  - Yan, W, Wu, X, Zhou, W, Fong, MY, Cao, M, Liu, J, Liu, X, Chen, C-H, Fadare, O, Pizzo, DP, Wu, J, Liu, L, Liu, X, Chin, AR, Ren, X, Chen, Y, Locasale, JW, and Wang, SE. "Cancer-cell-secreted exosomal miR-105 promotes tumour growth through the MYC-dependent metabolic reprogramming of stromal cells." Nature Cell Biology 20, no. 5 (May 2018): 597-609. Full Text
  - Locasale, JW. "New concepts in feedback regulation of glucose metabolism." Current Opinion in Systems Biology 8 (April 2018): 32-38. Full Text
  - Allen, AE, and Locasale, JW. "Glucose Metabolism in Cancer: The Saga of Pyruvate Kinase Continues." Cancer Cell 33, no. 3 (March 2018): 337-339. Full Text
  - Gao, X, Lee, K, Reid, MA, Sanderson, SM, Qiu, C, Li, S, Liu, J, and Locasale, JW. "Serine Availability Influences Mitochondrial Dynamics and Function through Lipid Metabolism." Cell Reports 22, no. 13 (March 2018): 3507-3520. Full Text
  - Hwang, I, Oh, H, Santo, E, Kim, D-Y, Chen, JW, Bronson, RT, Locasale, JW, Na, Y, Lee, J, Reed, S, Toth, M, Yu, WH, Muller, FL, and Paik, J. "FOXO protects against age-progressive axonal degeneration." Aging Cell 17, no. 1 (February 2018). Full Text
  - Dai, Z, Mentch, S, Gao, X, Nichenametla, S, and Locasale, J. "Methionine metabolism influences the genomic architecture of H3K4me3 with the link to gene expression encoded in peak width." (January 5, 2018). Full Text
  - Liu, X, Cooper, DE, Cluntun, AA, Warmoes, MO, Zhao, S, Reid, MA, Liu, J, Wellen, KE, Kirsch, DG, and Locasale, JW. "De Novo Acetate Production is Coupled to Central Carbon Metabolism in Mammals." (2018).
  - Lu, M, Sanderson, SM, Zessin, A, Ashcraft, KA, Jones, LW, Dewhirst, MW, Locasale, JW, and Hsu, DS. "Exercise inhibits tumor growth and central carbon metabolism in patient-derived xenograft models of colorectal cancer." Cancer & Metabolism 6 (January 2018): 14-null. Full Text
  - Zhao, F, Xiao, C, Evans, KS, Theivanthiran, T, DeVito, N, Holtzhausen, A, Liu, J, Liu, X, Boczkowski, D, Nair, S, Locasale, JW, and Hanks, BA. "Paracrine Wnt5a-β-Catenin Signaling Triggers a Metabolic Program that Drives Dendritic Cell Tolerization." Immunity 48, no. 1 (January 2018): 147-160.e7. Full Text Open Access Copy
  - Hershberger, KA, Abraham, DM, Martin, AS, Mao, L, Liu, J, Gu, H, Locasale, JW, and Hirschey, MD. "Sirtuin 5 is required for mouse survival in response to cardiac pressure overload." The Journal of Biological Chemistry 292, no. 48 (December 2017): 19767-19781. Full Text
  - Singleton, KR, Crawford, L, Tsui, E, Manchester, HE, Maertens, O, Liu, X, Liberti, MV, Magpusao, AN, Stein, EM, Tingley, JP, Frederick, DT, Boland, GM, Flaherty, KT, McCall, SJ, Krepler, C, Sproesser, K, Herlyn, M, Adams, DJ, Locasale, JW, Cichowski, K, Mukherjee, S, and Wood, KC. "Melanoma Therapeutic Strategies that Select against Resistance by Exploiting MYC-Driven Evolutionary Convergence." Cell Reports 21, no. 10 (December 2017): 2796-2812. Full Text
  - Reid, MA, Dai, Z, and Locasale, JW. "The impact of cellular metabolism on chromatin dynamics and epigenetics." Nature Cell Biology 19, no. 11 (November 2017): 1298-1306. (Review) Full Text
  - Reid, MA, Paik, J, and Locasale, JW. "A Missing Link to Vitamin B12 Metabolism." Cell 171, no. 4 (November 2017): 736-737. Full Text
  - Tang, S, Fang, Y, Huang, G, Xu, X, Padilla-Banks, E, Fan, W, Xu, Q, Sanderson, SM, Foley, JF, Dowdy, S, McBurney, MW, Fargo, DC, Williams, CJ, Locasale, JW, Guan, Z, and Li, X. "Methionine metabolism is essential for SIRT1-regulated mouse embryonic stem cell maintenance and embryonic development." The Embo Journal 36, no. 21 (November 2017): 3175-3193. Full Text
  - Liberti, MV, Dai, Z, Wardell, SE, Baccile, JA, Liu, X, Gao, X, Baldi, R, Mehrmohamadi, M, Johnson, MO, Madhukar, NS, Shestov, AA, Chio, IIC, Elemento, O, Rathmell, JC, Schroeder, FC, McDonnell, DP, and Locasale, JW. "A Predictive Model for Selective Targeting of the Warburg Effect through GAPDH Inhibition with a Natural Product." Cell Metabolism 26, no. 4 (October 2017): 648-659.e8. Full Text
  - Glass, OK, Bowie, M, Fuller, J, Darr, D, sary, JU, Boss, K, Choudhury, KR, Liu, X, Zhang, Z, Locasale, JW, Williams, C, Dewhirst, MW, Jones, LW, and Seewaldt, V. "Differential response to exercise in claudin-low breast cancer(Published online)." Oncotarget (September 19, 2017). Full Text Open Access Copy
  - Dai, Z, and Locasale, JW. "Understanding metabolism with flux analysis: From theory to application." Metabolic Engineering 43, no. Pt B (September 2017): 94-102. (Review) Full Text
  - Liu, X, and Locasale, JW. "Biochemistry: A toxin that fuels metabolism." Nature 548, no. 7669 (August 16, 2017): 533-534. Full Text
  - Martin, AS, Abraham, DM, Hershberger, KA, Bhatt, DP, Mao, L, Cui, H, Liu, J, Liu, X, Muehlbauer, MJ, Grimsrud, PA, Locasale, JW, Payne, RM, and Hirschey, MD. "Nicotinamide mononucleotide requires SIRT3 to improve cardiac function and bioenergetics in a Friedreich's ataxia cardiomyopathy model." Jci Insight 2, no. 14 (July 20, 2017). Full Text
  - Garcia, J, Bagwell, J, Njaine, B, Norman, J, Levic, DS, Wopat, S, Miller, SE, Liu, X, Locasale, JW, Stainier, DYR, and Bagnat, M. "Sheath Cell Invasion and Trans-differentiation Repair Mechanical Damage Caused by Loss of Caveolae in the Zebrafish Notochord." Current Biology : Cb 27, no. 13 (July 2017): 1982-1989.e3. Full Text
  - Torrano, V, Valcarcel-Jimenez, L, Cortazar, AR, Liu, X, Urosevic, J, Castillo-Martin, M, Fernandez-Ruiz, S, Morciano, G, Caro-Maldonado, A, Guiu, M, Zuniga-Garcia, P, Graupera, M, Bellmunt, A, Pandya, P, Lorente, M, Martin-Martin, N, Sutherland, JD, Sanchez-Mosquera, P, Bozal-Basterra, L, Zabala-Letona, A, Arruabarrena-Aristorena, A, Berenguer, A, Embade, N, Ugalde-Olano, A, Lacasa-Viscasillas, I, Loizaga-Iriarte, A, Unda-Urzaiz, M, Schultz, N, Aransay, AM, Sanz-Moreno, V, Barrio, R, and Velasco, G et al. "The metabolic co-regulator PGC1 alpha suppresses prostate cancer metastasis (vol 18, pg 645, 2016)." NATURE CELL BIOLOGY 19, no. 7 (July 2017): 873-873. Full Text Link to Item
  - Torrano, V, Valcarcel-Jimenez, L, Cortazar, AR, Liu, X, Urosevic, J, Castillo-Martin, M, Fernández-Ruiz, S, Morciano, G, Caro-Maldonado, A, Guiu, M, Zúñiga-García, P, Graupera, M, Bellmunt, A, Pandya, P, Lorente, M, Martín-Martín, N, Sutherland, JD, Sanchez-Mosquera, P, Bozal-Basterra, L, Zabala-Letona, A, Arruabarrena-Aristorena, A, Berenguer, A, Embade, N, Ugalde-Olano, A, Lacasa-Viscasillas, I, Loizaga-Iriarte, A, Unda-Urzaiz, M, Schultz, N, Aransay, AM, Sanz-Moreno, V, Barrio, R, and Velasco, G et al. "Erratum: The metabolic co-regulator PGC1α suppresses prostate cancer metastasis." Nature cell biology 19, no. 7 (June 2017): 873-. Full Text
  - Liu, X, and Locasale, JW. "Metabolomics reveals intratumor heterogeneity - Implications for precision medicine." Ebiomedicine 19 (May 2017): 4-5. Full Text
  - Wang, X, Yang, K, Xie, Q, Wu, Q, Mack, SC, Shi, Y, Kim, LJY, Prager, BC, Flavahan, WA, Liu, X, Singer, M, Hubert, CG, Miller, TE, Zhou, W, Huang, Z, Fang, X, Regev, A, Suvà, ML, Hwang, TH, Locasale, JW, Bao, S, and Rich, JN. "Purine synthesis promotes maintenance of brain tumor initiating cells in glioma." Nature Neuroscience 20, no. 5 (May 2017): 661-673. Full Text
  - Gao, X, Reid, MA, Kong, M, and Locasale, JW. "Metabolic interactions with cancer epigenetics." Molecular Aspects of Medicine 54 (April 2017): 50-57. (Review) Full Text
  - Liu, X, and Locasale, JW. "Metabolomics: A Primer." Trends in Biochemical Sciences 42, no. 4 (April 2017): 274-284. (Review) Full Text
  - Cluntun, AA, Lukey, MJ, Cerione, RA, and Locasale, JW. "Glutamine Metabolism in Cancer: Understanding the Heterogeneity." Trends in Cancer 3, no. 3 (March 2017): 169-180. (Review) Full Text
  - McDonald, OG, Li, X, Saunders, T, Tryggvadottir, R, Mentch, SJ, Warmoes, MO, Word, AE, Carrer, A, Salz, TH, Natsume, S, Stauffer, KM, Makohon-Moore, A, Zhong, Y, Wu, H, Wellen, KE, Locasale, JW, Iacobuzio-Donahue, CA, and Feinberg, AP. "Epigenomic reprogramming during pancreatic cancer progression links anabolic glucose metabolism to distant metastasis." Nature Genetics 49, no. 3 (March 2017): 367-376. Full Text
  - Dai, Z, and Locasale, JW. "Metabolic pattern formation in the tumor microenvironment." Molecular Systems Biology 13, no. 2 (February 9, 2017): 915-null. Full Text Open Access Copy
  - Mattocks, DAL, Mentch, SJ, Shneyder, J, Ables, GP, Sun, D, Richie, JP, Locasale, JW, and Nichenametla, SN. "Short term methionine restriction increases hepatic global DNA methylation in adult but not young male C57BL/6J mice." Experimental Gerontology 88 (February 2017): 1-8. Full Text
  - Mehrmohamadi, M, Jeong, SH, and Locasale, JW. "Molecular features that predict the response to antimetabolite chemotherapies." Cancer & Metabolism 5 (January 2017): 8-null. Full Text
  - Salerno, S, Mehrmohamadi, M, Liberti, MV, Wan, M, Wells, MT, Booth, JG, and Locasale, JW. "RRmix: A method for simultaneous batch effect correction and analysis of metabolomics data in the absence of internal standards." Plos One 12, no. 6 (January 2017): e0179530-null. Full Text
  - Wang, Q, Liberti, MV, Liu, P, Deng, X, Liu, Y, Locasale, JW, and Lai, L. "Rational Design of Selective Allosteric Inhibitors of PHGDH and Serine Synthesis with Anti-tumor Activity." Cell Chemical Biology 24, no. 1 (January 2017): 55-65. Full Text
  - Mehrmohamadi, M, Mentch, LK, Clark, AG, and Locasale, JW. "Integrative modelling of tumour DNA methylation quantifies the contribution of metabolism." Nature Communications 7 (December 14, 2016): 13666-null. Full Text
  - Gao, X, and Locasale, JW. "Serine Metabolism Links Tumor Suppression to the Epigenetic Landscape." Cell metabolism 24, no. 6 (December 2016): 777-779. Full Text
  - Gerriets, VA, Kishton, RJ, Johnson, MO, Cohen, S, Siska, PJ, Nichols, AG, Warmoes, MO, de Cubas, AA, MacIver, NJ, Locasale, JW, Turka, LA, Wells, AD, and Rathmell, JC. "Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression." Nature Immunology 17, no. 12 (December 2016): 1459-1466. Full Text
  - Liu, X, Romero, IL, Litchfield, LM, Lengyel, E, and Locasale, JW. "Metformin Targets Central Carbon Metabolism and Reveals Mitochondrial Requirements in Human Cancers." Cell Metabolism 24, no. 5 (November 2016): 728-739. Full Text
  - Pan, M, Reid, MA, Lowman, XH, Kulkarni, RP, Tran, TQ, Liu, X, Yang, Y, Hernandez-Davies, JE, Rosales, KK, Li, H, Hugo, W, Song, C, Xu, X, Schones, DE, Ann, DK, Gradinaru, V, Lo, RS, Locasale, JW, and Kong, M. "Regional glutamine deficiency in tumours promotes dedifferentiation through inhibition of histone demethylation." Nature Cell Biology 18, no. 10 (October 2016): 1090-1101. Full Text
  - Zeng, H, Cohen, S, Guy, C, Shrestha, S, Neale, G, Brown, SA, Cloer, C, Kishton, RJ, Gao, X, Youngblood, B, Do, M, Li, MO, Locasale, JW, Rathmell, JC, and Chi, H. "mTORC1 and mTORC2 Kinase Signaling and Glucose Metabolism Drive Follicular Helper T Cell Differentiation." Immunity 45, no. 3 (September 13, 2016): 540-554. Full Text
  - Dai, Z, Shestov, AA, Lai, L, and Locasale, JW. "A Flux Balance of Glucose Metabolism Clarifies the Requirements of the Warburg Effect." Biophysical Journal 111, no. 5 (September 2016): 1088-1100. Full Text
  - Reid, MA, Lowman, XH, Pan, M, Tran, TQ, Warmoes, MO, Ishak Gabra, MB, Yang, Y, Locasale, JW, and Kong, M. "IKKβ promotes metabolic adaptation to glutamine deprivation via phosphorylation and inhibition of PFKFB3." Genes & Development 30, no. 16 (August 2016): 1837-1851. Full Text
  - Liberti, MV, and Locasale, JW. "Metabolism: A new layer of glycolysis." Nature Chemical Biology 12, no. 8 (July 2016): 577-578. Full Text
  - Ser, Z, Gao, X, Johnson, C, Mehrmohamadi, M, Liu, X, Li, S, and Locasale, JW. "Targeting One Carbon Metabolism with an Antimetabolite Disrupts Pyrimidine Homeostasis and Induces Nucleotide Overflow." Cell Reports 15, no. 11 (June 2, 2016): 2367-2376. Full Text
  - Torrano, V, Valcarcel-Jimenez, L, Cortazar, AR, Liu, X, Urosevic, J, Castillo-Martin, M, Fernández-Ruiz, S, Morciano, G, Caro-Maldonado, A, Guiu, M, Zúñiga-García, P, Graupera, M, Bellmunt, A, Pandya, P, Lorente, M, Martín-Martín, N, Sutherland, JD, Sanchez-Mosquera, P, Bozal-Basterra, L, Zabala-Letona, A, Arruabarrena-Aristorena, A, Berenguer, A, Embade, N, Ugalde-Olano, A, Lacasa-Viscasillas, I, Loizaga-Iriarte, A, Unda-Urzaiz, M, Schultz, N, Aransay, AM, Sanz-Moreno, V, Barrio, R, Velasco, G, Pinton, P, Cordon-Cardo, C, Locasale, JW, Gomis, RR, and Carracedo, A. "The metabolic co-regulator PGC1α suppresses prostate cancer metastasis." Nature Cell Biology 18, no. 6 (June 2016): 645-656. Full Text
  - Sadhukhan, S, Liu, X, Ryu, D, Nelson, OD, Stupinski, JA, Li, Z, Chen, W, Zhang, S, Weiss, RS, Locasale, JW, Auwerx, J, and Lin, H. "Metabolomics-assisted proteomics identifies succinylation and SIRT5 as important regulators of cardiac function." Proceedings of the National Academy of Sciences of the United States of America 113, no. 16 (April 5, 2016): 4320-4325. Full Text
  - Kishton, RJ, Barnes, CE, Nichols, AG, Cohen, S, Gerriets, VA, Siska, PJ, Macintyre, AN, Goraksha-Hicks, P, de Cubas, AA, Liu, T, Warmoes, MO, Abel, ED, Yeoh, AEJ, Gershon, TR, Rathmell, WK, Richards, KL, Locasale, JW, and Rathmell, JC. "AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival." Cell Metabolism 23, no. 4 (April 2016): 649-662. Full Text
  - Park, S, Chang, C-Y, Safi, R, Liu, X, Baldi, R, Jasper, JS, Anderson, GR, Liu, T, Rathmell, JC, Dewhirst, MW, Wood, KC, Locasale, JW, and McDonnell, DP. "ERRα-Regulated Lactate Metabolism Contributes to Resistance to Targeted Therapies in Breast Cancer." Cell Reports 15, no. 2 (April 2016): 323-335. Full Text
  - Jurkowska, H, Niewiadomski, J, Hirschberger, LL, Roman, HB, Mazor, KM, Liu, X, Locasale, JW, Park, E, and Stipanuk, MH. "Downregulation of hepatic betaine:homocysteine methyltransferase (BHMT) expression in taurine-deficient mice is reversed by taurine supplementation in vivo." Amino Acids 48, no. 3 (March 2016): 665-676. Full Text
  - Liberti, MV, and Locasale, JW. "The Warburg Effect: How Does it Benefit Cancer Cells?." Trends in Biochemical Sciences 41, no. 3 (March 2016): 211-218. (Review) Full Text
  - Liberti, MV, and Locasale, JW. "Correction to: 'The Warburg Effect: How Does it Benefit Cancer Cells?': [Trends in Biochemical Sciences, 41 (2016) 211]." Trends in Biochemical Sciences 41, no. 3 (March 2016): 287-null. Full Text
  - Chiyoda, T, Liu, X, Lengyel, E, Locasale, J, and Romero, I. "Abstract A68: Sphingosine kinase 1 as a mediator and predictor of metformin's protective effect in ovarian cancer." Clinical Cancer Research 22, no. 2 Supplement (January 15, 2016): A68-A68. Full Text
  - Sumita, K, Lo, Y-H, Takeuchi, K, Senda, M, Kofuji, S, Ikeda, Y, Terakawa, J, Sasaki, M, Yoshino, H, Majd, N, Zheng, Y, Kahoud, ER, Yokota, T, Emerling, BM, Asara, JM, Ishida, T, Locasale, JW, Daikoku, T, Anastasiou, D, Senda, T, and Sasaki, AT. "The Lipid Kinase PI5P4Kβ Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis." Molecular Cell 61, no. 2 (January 7, 2016): 187-198. Full Text
  - Mentch, SJ, and Locasale, JW. "One-carbon metabolism and epigenetics: understanding the specificity." Annals of the New York Academy of Sciences 1363 (January 2016): 91-98. (Review) Full Text
  - Niewiadomski, J, Zhou, JQ, Roman, HB, Liu, X, Hirschberger, LL, Locasale, JW, and Stipanuk, MH. "Effects of a block in cysteine catabolism on energy balance and fat metabolism in mice." Annals of the New York Academy of Sciences 1363 (January 2016): 99-115. Full Text
  - Barker, BE, Sadagopan, N, Wang, Y, Smallbone, K, Myers, CR, Xi, H, Locasale, JW, and Gu, Z. "A robust and efficient method for estimating enzyme complex abundance and metabolic flux from expression data." Computational Biology and Chemistry 59 Pt B (December 2015): 98-112. Full Text
  - Block, KI, Gyllenhaal, C, Lowe, L, Amedei, A, Amin, ARMR, Amin, A, Aquilano, K, Arbiser, J, Arreola, A, Arzumanyan, A, Ashraf, SS, Azmi, AS, Benencia, F, Bhakta, D, Bilsland, A, Bishayee, A, Blain, SW, Block, PB, Boosani, CS, Carey, TE, Carnero, A, Carotenuto, M, Casey, SC, Chakrabarti, M, Chaturvedi, R, Chen, GZ, Chen, H, Chen, S, Chen, YC, Choi, BK, Ciriolo, MR, Coley, HM, Collins, AR, Connell, M, Crawford, S, Curran, CS, Dabrosin, C, Damia, G, Dasgupta, S, DeBerardinis, RJ, Decker, WK, Dhawan, P, Diehl, AME, Dong, J-T, Dou, QP, Drew, JE, Elkord, E, El-Rayes, B, Feitelson, MA, Felsher, DW, Ferguson, LR, Fimognari, C, Firestone, GL, Frezza, C, Fujii, H, Fuster, MM, Generali, D, Georgakilas, AG, Gieseler, F, Gilbertson, M, Green, MF, Grue, B, Guha, G, Halicka, D, Helferich, WG, Heneberg, P, Hentosh, P, Hirschey, MD, Hofseth, LJ, Holcombe, RF, Honoki, K, Hsu, H-Y, Huang, GS, Jensen, LD, Jiang, WG, Jones, LW, Karpowicz, PA, Keith, WN, Kerkar, SP, Khan, GN, Khatami, M, Ko, YH, Kucuk, O, Kulathinal, RJ, Kumar, NB, Kwon, BS, Le, A, Lea, MA, Lee, H-Y, Lichtor, T, Lin, L-T, Locasale, JW, Lokeshwar, BL, Longo, VD, Lyssiotis, CA, MacKenzie, KL, Malhotra, M, Marino, M, Martinez-Chantar, ML, Matheu, A, Maxwell, C, McDonnell, E, Meeker, AK, Mehrmohamadi, M, Mehta, K, Michelotti, GA, Mohammad, RM, Mohammed, SI, Morre, DJ, Muralidhar, V, Muqbil, I, Murphy, MP, Nagaraju, GP, Nahta, R, Niccolai, E, Nowsheen, S, Panis, C, Pantano, F, Parslow, VR, Pawelec, G, Pedersen, PL, Poore, B, Poudyal, D, Prakash, S, Prince, M, Raffaghello, L, Rathmell, JC, Rathmell, WK, Ray, SK, Reichrath, J, Rezazadeh, S, Ribatti, D, Ricciardiello, L, Robey, RB, Rodier, F, Rupasinghe, HPV, Russo, GL, Ryan, EP, Samadi, AK, Sanchez-Garcia, I, Sanders, AJ, Santini, D, Sarkar, M, Sasada, T, Saxena, NK, Shackelford, RE, Shantha Kumara, HMC, Sharma, D, Shin, DM, Sidransky, D, Siegelin, MD, Signori, E, Singh, N, Sivanand, S, Sliva, D, Smythe, C, Spagnuolo, C, Stafforini, DM, Stagg, J, Subbarayan, PR, Sundin, T, Talib, WH, Thompson, SK, Tran, PT, Ungefroren, H, Vander Heiden, MG, Venkateswaran, V, Vinay, DS, Vlachostergios, PJ, Wang, Z, Wellen, KE, Whelan, RL, Yang, ES, Yang, H, Yang, X, Yaswen, P, Yedjou, C, Yin, X, Zhu, J, and Zollo, M. "Designing a broad-spectrum integrative approach for cancer prevention and treatment." Seminars in Cancer Biology 35 Suppl (December 2015): S276-S304. (Review) Full Text
  - Hirschey, MD, DeBerardinis, RJ, Diehl, AME, Drew, JE, Frezza, C, Green, MF, Jones, LW, Ko, YH, Le, A, Lea, MA, Locasale, JW, Longo, VD, Lyssiotis, CA, McDonnell, E, Mehrmohamadi, M, Michelotti, G, Muralidhar, V, Murphy, MP, Pedersen, PL, Poore, B, Raffaghello, L, Rathmell, JC, Sivanand, S, Vander Heiden, MG, Wellen, KE, and Target Validation Team, . "Dysregulated metabolism contributes to oncogenesis." Seminars in Cancer Biology 35 Suppl (December 2015): S129-S150. (Review) Full Text
  - Colak, G, Pougovkina, O, Dai, L, Tan, M, Te Brinke, H, Huang, H, Cheng, Z, Park, J, Wan, X, Liu, X, Yue, WW, Wanders, RJA, Locasale, JW, Lombard, DB, de Boer, VCJ, and Zhao, Y. "Proteomic and Biochemical Studies of Lysine Malonylation Suggest Its Malonic Aciduria-associated Regulatory Role in Mitochondrial Function and Fatty Acid Oxidation." Molecular & Cellular Proteomics : Mcp 14, no. 11 (November 2015): 3056-3071. Full Text
  - Mentch, SJ, Mehrmohamadi, M, Huang, L, Liu, X, Gupta, D, Mattocks, D, Gómez Padilla, P, Ables, G, Bamman, MM, Thalacker-Mercer, AE, Nichenametla, SN, and Locasale, JW. "Histone Methylation Dynamics and Gene Regulation Occur through the Sensing of One-Carbon Metabolism." Cell Metabolism 22, no. 5 (November 2015): 861-873. Full Text
  - Douris, N, Melman, T, Pecherer, JM, Pissios, P, Flier, JS, Cantley, LC, Locasale, JW, and Maratos-Flier, E. "Adaptive changes in amino acid metabolism permit normal longevity in mice consuming a low-carbohydrate ketogenic diet." Biochimica et biophysica acta 1852, no. 10 Pt A (October 2015): 2056-2065. Full Text
  - Mehrmohamadi, M, and Locasale, JW. "Context dependent utilization of serine in cancer." Molecular & cellular oncology 2, no. 4 (October 2015): e996418-. Full Text
  - Chourasia, AH, Tracy, K, Frankenberger, C, Boland, ML, Sharifi, MN, Drake, LE, Sachleben, JR, Asara, JM, Locasale, JW, Karczmar, GS, and Macleod, KF. "Mitophagy defects arising from BNip3 loss promote mammary tumor progression to metastasis." Embo Reports 16, no. 9 (September 2015): 1145-1163. Full Text
  - Ho, P-C, Bihuniak, JD, Macintyre, AN, Staron, M, Liu, X, Amezquita, R, Tsui, Y-C, Cui, G, Micevic, G, Perales, JC, Kleinstein, SH, Abel, ED, Insogna, KL, Feske, S, Locasale, JW, Bosenberg, MW, Rathmell, JC, and Kaech, SM. "Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses." Cell 162, no. 6 (September 2015): 1217-1228. Full Text
  - Buescher, JM, Antoniewicz, MR, Boros, LG, Burgess, SC, Brunengraber, H, Clish, CB, DeBerardinis, RJ, Feron, O, Frezza, C, Ghesquiere, B, Gottlieb, E, Hiller, K, Jones, RG, Kamphorst, JJ, Kibbey, RG, Kimmelman, AC, Locasale, JW, Lunt, SY, Maddocks, ODK, Malloy, C, Metallo, CM, Meuillet, EJ, Munger, J, Nöh, K, Rabinowitz, JD, Ralser, M, Sauer, U, Stephanopoulos, G, St-Pierre, J, Tennant, DA, Wittmann, C, Vander Heiden, MG, Vazquez, A, Vousden, K, Young, JD, Zamboni, N, and Fendt, S-M. "A roadmap for interpreting (13)C metabolite labeling patterns from cells." Current Opinion in Biotechnology 34 (August 2015): 189-201. (Review) Full Text
  - Simões, RV, Serganova, IS, Kruchevsky, N, Leftin, A, Shestov, AA, Thaler, HT, Sukenick, G, Locasale, JW, Blasberg, RG, Koutcher, JA, and Ackerstaff, E. "Metabolic plasticity of metastatic breast cancer cells: adaptation to changes in the microenvironment." Neoplasia (New York, N.Y.) 17, no. 8 (August 2015): 671-684. Full Text
  - Liu, X, Sadhukhan, S, Sun, S, Wagner, GR, Hirschey, MD, Qi, L, Lin, H, and Locasale, JW. "High-Resolution Metabolomics with Acyl-CoA Profiling Reveals Widespread Remodeling in Response to Diet." Molecular & Cellular Proteomics : Mcp 14, no. 6 (June 2015): 1489-1500. Full Text
  - Ser, Z, Liu, X, Tang, NN, and Locasale, JW. "Extraction parameters for metabolomics from cultured cells." Analytical biochemistry 475 (April 2015): 22-28. Full Text
  - Chen, J, Lee, H-J, Wu, X, Huo, L, Kim, S-J, Xu, L, Wang, Y, He, J, Bollu, LR, Gao, G, Su, F, Briggs, J, Liu, X, Melman, T, Asara, JM, Fidler, IJ, Cantley, LC, Locasale, JW, and Weihua, Z. "Gain of glucose-independent growth upon metastasis of breast cancer cells to the brain." Cancer Research 75, no. 3 (February 2015): 554-565. Full Text
  - Madhukar, NS, Warmoes, MO, and Locasale, JW. "Organization of enzyme concentration across the metabolic network in cancer cells." PloS one 10, no. 1 (January 26, 2015): e0117131-. Full Text
  - Cluntun, AA, Huang, H, Dai, L, Liu, X, Zhao, Y, and Locasale, JW. "The rate of glycolysis quantitatively mediates specific histone acetylation sites." Cancer & metabolism 3 (January 2015): 10-. Full Text
  - Crowe, KM, Allison, D, and Bioactive Food Components Conference Speakers, . "Evaluating bioactive food components in obesity and cancer prevention." Critical reviews in food science and nutrition 55, no. 5 (January 2015): 732-734. (Review) Full Text
  - Gerriets, VA, Kishton, RJ, Nichols, AG, Macintyre, AN, Inoue, M, Ilkayeva, O, Winter, PS, Liu, X, Priyadharshini, B, Slawinska, ME, Haeberli, L, Huck, C, Turka, LA, Wood, KC, Hale, LP, Smith, PA, Schneider, MA, MacIver, NJ, Locasale, JW, Newgard, CB, Shinohara, ML, and Rathmell, JC. "Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation." The Journal of Clinical Investigation 125, no. 1 (January 2015): 194-207. Full Text Open Access Copy
  - Johnson, C, Warmoes, MO, Shen, X, and Locasale, JW. "Epigenetics and cancer metabolism." Cancer Letters 356, no. 2 Pt A (January 2015): 309-314. (Review) Full Text
  - Huang, L, Kim, D, Liu, X, Myers, CR, and Locasale, JW. "Estimating relative changes of metabolic fluxes." PLoS computational biology 10, no. 11 (November 20, 2014): e1003958-. Full Text
  - Liu, T, Kishton, RJ, Macintyre, AN, Gerriets, VA, Xiang, H, Liu, X, Abel, ED, Rizzieri, D, Locasale, JW, and Rathmell, JC. "Glucose transporter 1-mediated glucose uptake is limiting for B-cell acute lymphoblastic leukemia anabolic metabolism and resistance to apoptosis." Cell death & disease 5, no. 11 (November 6, 2014): e1516--. Full Text
  - Mehrmohamadi, M, Liu, X, Shestov, AA, and Locasale, JW. "Characterization of the usage of the serine metabolic network in human cancer." Cell Reports 9, no. 4 (November 6, 2014): 1507-1519. Full Text
  - Warmoes, MO, and Locasale, JW. "Heterogeneity of glycolysis in cancers and therapeutic opportunities." Biochemical pharmacology 92, no. 1 (November 2014): 12-21. (Review) Full Text
  - Liu, T, Kishton, RJ, Macintyre, AN, Gerriets, VA, Xiang, H, Liu, X, Abel, ED, Rizzieri, D, Locasale, JW, and Rathmell, JC. "Glucose transporter 1-mediated glucose uptake is limiting for B-cell acute lymphoblastic leukemia anabolic metabolism and resistance to apoptosis." Cell Death & Disease 5 (October 16, 2014): e1470-null. Full Text
  - Shestov, AA, Liu, X, Ser, Z, Cluntun, AA, Hung, YP, Huang, L, Kim, D, Le, A, Yellen, G, Albeck, JG, and Locasale, JW. "Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step." Elife 3 (July 9, 2014). Full Text
  - Shestov, AA, Liu, X, Ser, Z, Cluntun, AA, Hung, YP, Huang, L, Kim, D, Le, A, Yellen, G, Albeck, JG, and Locasale, JW. "Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step." ELIFE 3 (July 9, 2014). Full Text Link to Item
  - Liu, X, Ser, Z, Cluntun, AA, Mentch, SJ, and Locasale, JW. "A strategy for sensitive, large scale quantitative metabolomics." Journal of visualized experiments : JoVE , no. 87 (May 27, 2014). Full Text
  - Dasgupta, T, Croll, DH, Owen, JA, Vander Heiden, MG, Locasale, JW, Alon, U, Cantley, LC, and Gunawardena, J. "A fundamental trade-off in covalent switching and its circumvention by enzyme bifunctionality in glucose homeostasis." The Journal of Biological Chemistry 289, no. 19 (May 2014): 13010-13025. Full Text
  - Sun, S, Shi, G, Han, X, Francisco, AB, Ji, Y, Mendonça, N, Liu, X, Locasale, JW, Simpson, KW, Duhamel, GE, Kersten, S, Yates, JR, Long, Q, and Qi, L. "Erratum: Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation, endoplasmic reticulum homeostasis, and survival (Proceedings of the National Academy of Sciences of the United States of America (2014) 111, 5, (E582-E591) doi:10.1073/pnas.1318114111)." Proceedings of the National Academy of Sciences of the United States of America 111, no. 16 (April 22, 2014): 6115-null. Full Text
  - Liu, X, Ser, Z, and Locasale, JW. "Development and quantitative evaluation of a high-resolution metabolomics technology." Analytical Chemistry 86, no. 4 (February 2014): 2175-2184. Full Text
  - Sun, S, Shi, G, Han, X, Francisco, AB, Ji, Y, Mendonça, N, Liu, X, Locasale, JW, Simpson, KW, Duhamel, GE, Kersten, S, Yates, JR, Long, Q, and Qi, L. "Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation, endoplasmic reticulum homeostasis, and survival." Proceedings of the National Academy of Sciences of the United States of America 111, no. 5 (February 2014): E582-E591. Full Text
  - Chen, K-Y, Liu, X, Bu, P, Lin, C-S, Rakhilin, N, Locasale, JW, and Shen, X. "A metabolic signature of colon cancer initiating cells." Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual Conference 2014 (January 2014): 4759-4762. Full Text
  - Johnson, C, Chen, K-Y, Liu, X, Bu, P, Locasale, J, and Shen, X. "A metabolic signature of colon cancer initiating cells." Cancer & Metabolism 2, no. Suppl 1 (January 2014): P32-P32. Full Text
  - Liu, T, Kishton, RJ, Macintyre, AN, Gerriets, VA, Xiang, H, Liu, X, Abel, ED, Rizzieri, D, Locasale, JW, and Rathmell, JC. "Glucose transporter 1-mediated glucose uptake is limiting for B-cell acute lymphoblastic leukemia anabolic metabolism and resistance to apoptosis." Cell Death & Disease 5 (2014): e1516-null. Full Text
  - Parkhitko, AA, Priolo, C, Coloff, JL, Yun, J, Wu, JJ, Mizumura, K, Xu, W, Malinowska, IA, Yu, J, Kwiatkowski, DJ, Locasale, JW, Asara, JM, Choi, AMK, Finkel, T, and Henske, EP. "Autophagy-dependent metabolic reprogramming sensitizes TSC2-deficient cells to the antimetabolite 6-aminonicotinamide." Molecular Cancer Research : Mcr 12, no. 1 (January 2014): 48-57. Full Text
  - Shestov, AA, Barker, B, Gu, Z, and Locasale, JW. "Computational approaches for understanding energy metabolism." Wiley interdisciplinary reviews. Systems biology and medicine 5, no. 6 (November 2013): 733-750. (Review) Full Text
  - Locasale, JW. "Serine, glycine and one-carbon units: cancer metabolism in full circle." Nature Reviews. Cancer 13, no. 8 (August 2013): 572-583. (Review) Full Text
  - Hu, J, Locasale, JW, Bielas, JH, O'Sullivan, J, Sheahan, K, Cantley, LC, Vander Heiden, MG, and Vitkup, D. "Heterogeneity of tumor-induced gene expression changes in the human metabolic network." Nature Biotechnology 31, no. 6 (June 2013): 522-529. Full Text
  - Baker, R, Lewis, SM, Sasaki, AT, Wilkerson, EM, Locasale, JW, Cantley, LC, Kuhlman, B, Dohlman, HG, and Campbell, SL. "Site-specific monoubiquitination activates Ras by impeding GTPase-activating protein function." Nature Structural & Molecular Biology 20, no. 1 (January 2013): 46-52. Full Text
  - Shyh-Chang, N, Locasale, JW, Lyssiotis, CA, Zheng, Y, Teo, RY, Ratanasirintrawoot, S, Zhang, J, Onder, T, Unternaehrer, JJ, Zhu, H, Asara, JM, Daley, GQ, and Cantley, LC. "Influence of threonine metabolism on S-adenosylmethionine and histone methylation." Science (New York, N.Y.) 339, no. 6116 (January 2013): 222-226. Full Text
  - Locasale, JW. "The consequences of enhanced cell-autonomous glucose metabolism." Trends in endocrinology and metabolism: TEM 23, no. 11 (November 2012): 545-551. Full Text
  - Locasale, JW, Melman, T, Song, S, Yang, X, Swanson, KD, Cantley, LC, Wong, ET, and Asara, JM. "Metabolomics of human cerebrospinal fluid identifies signatures of malignant glioma." Molecular & Cellular Proteomics : Mcp 11, no. 6 (June 2012): M111.014688-null. Full Text
  - Ying, H, Kimmelman, AC, Lyssiotis, CA, Hua, S, Chu, GC, Fletcher-Sananikone, E, Locasale, JW, Son, J, Zhang, H, Coloff, JL, Yan, H, Wang, W, Chen, S, Viale, A, Zheng, H, Paik, J-H, Lim, C, Guimaraes, AR, Martin, ES, Chang, J, Hezel, AF, Perry, SR, Hu, J, Gan, B, Xiao, Y, Asara, JM, Weissleder, R, Wang, YA, Chin, L, Cantley, LC, and DePinho, RA. "Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism." Cell 149, no. 3 (April 2012): 656-670. Full Text
  - Lyssiotis, CA, Anastasiou, D, Locasale, JW, Vander Heiden, MG, Christofk, HR, and Cantley, LC. "Cellular control mechanisms that regulate pyruvate kinase M2 activity and promote cancer growth." Biomedical Research 23, no. SPEC. ISSUE (February 23, 2012): 213-217.
  - Locasale, JW, Grassian, A, Beroukhim, R, Meyerson, M, Wagner, G, Asara, JM, Brugge, JS, Vander Heiden, MG, and Cantley, LC. "Amplification of phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis." Bmc Proceedings 6, no. Suppl 3 (January 2012): O15-O15. Full Text
  - Locasale, JW, Melman, T, Song, S, Yang, X, Swanson, KD, Cantley, LC, Wong, ET, and Asara, JM. "Metabolomics of human cerebrospinal fluid identifies signatures of malignant glioma." Molecular & cellular proteomics : MCP 11, no. 6 (2012): M111.014688-. Full Text
  - Locasale, JW, and Zeskind, BJ. "Maximizing the efficacy of angiogenesis inhibitors." Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology 30, no. 3 (January 2012): 337-338. (Letter) Full Text
  - Locasale, JW. "Metabolic rewiring drives resistance to targeted cancer therapy." Molecular Systems Biology 8 (January 2012): 597-null. Full Text
  - Yun, J, Johnson, JL, Hanigan, CL, and Locasale, JW. "Interactions between epigenetics and metabolism in cancers." Frontiers in Oncology 2 (January 2012): 163-null. Full Text
  - Shyh-Chang, N, Zheng, Y, Locasale, JW, and Cantley, LC. "Human pluripotent stem cells decouple respiration from energy production." The EMBO journal 30, no. 24 (December 14, 2011): 4851-4852. Full Text
  - Locasale, JW, and Zeskind, B. "IL-6 and ovarian cancer--letter." Clinical cancer research : an official journal of the American Association for Cancer Research 17, no. 24 (December 6, 2011): 7837-. (Letter) Full Text
  - Anastasiou, D, Poulogiannis, G, Asara, JM, Boxer, MB, Jiang, J-K, Shen, M, Bellinger, G, Sasaki, AT, Locasale, JW, Auld, DS, Thomas, CJ, Vander Heiden, MG, and Cantley, LC. "Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses." Science (New York, N.Y.) 334, no. 6060 (December 2011): 1278-1283. Full Text
  - Mullarky, E, Mattaini, KR, Vander Heiden, MG, Cantley, LC, and Locasale, JW. "PHGDH amplification and altered glucose metabolism in human melanoma." Pigment Cell & Melanoma Research 24, no. 6 (December 2011): 1112-1115. (Review) Full Text
  - Locasale, JW, and Cantley, LC. "Genetic selection for enhanced serine metabolism in cancer development." Cell cycle (Georgetown, Tex.) 10, no. 22 (November 15, 2011): 3812-3813. Full Text
  - "METABOLIC PATHWAYS." Neuro Oncology 13, no. Suppl 3 (November 2011): iii69-iii72. Full Text
  - Locasale, JW, Melman, T, Song, SS, Yang, X, Swanson, KD, Cantley, LC, Asara, JM, and Wong, ET. "METABOLOMICS PROFILING OF PATIENT CEREBROSPINAL FLUID IDENTIFIES SIGNATURES OF MALIGNANT GLIOMA." NEURO-ONCOLOGY 13 (November 2011): 69-69. Link to Item
  - Gao, D, Inuzuka, H, Tan, M-KM, Fukushima, H, Locasale, JW, Liu, P, Wan, L, Zhai, B, Chin, YR, Shaik, S, Lyssiotis, CA, Gygi, SP, Toker, A, Cantley, LC, Asara, JM, Harper, JW, and Wei, W. "mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR." Molecular cell 44, no. 2 (October 2011): 290-303. Full Text
  - Locasale, JW, and Cantley, LC. "Metabolic flux and the regulation of mammalian cell growth." Cell Metabolism 14, no. 4 (October 2011): 443-451. (Review) Full Text
  - Yi, CH, Pan, H, Seebacher, J, Jang, I-H, Hyberts, SG, Heffron, GJ, Vander Heiden, MG, Yang, R, Li, F, Locasale, JW, Sharfi, H, Zhai, B, Rodriguez-Mias, R, Luithardt, H, Cantley, LC, Daley, GQ, Asara, JM, Gygi, SP, Wagner, G, Liu, C-F, and Yuan, J. "Metabolic regulation of protein N-alpha-acetylation by Bcl-xL promotes cell survival." Cell 146, no. 4 (August 2011): 607-620. Full Text
  - Locasale, JW, Grassian, AR, Melman, T, Lyssiotis, CA, Mattaini, KR, Bass, AJ, Heffron, G, Metallo, CM, Muranen, T, Sharfi, H, Sasaki, AT, Anastasiou, D, Mullarky, E, Vokes, NI, Sasaki, M, Beroukhim, R, Stephanopoulos, G, Ligon, AH, Meyerson, M, Richardson, AL, Chin, L, Wagner, G, Asara, JM, Brugge, JS, Cantley, LC, and Vander Heiden, MG. "Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis." Nature Genetics 43, no. 9 (July 31, 2011): 869-874. Full Text
  - CANTLEY LEWIS C, , VANDER HEIDEN MATTHEW, , LOCASALE JASON, , and SHARFI HADAR, . "METHODS AND COMPOSITIONS FOR THE DIAGNOSIS AND TREATMENT OF CELLULAR PROLIFERATIVE DISORDERS." (May 26, 2011).
  - Yang, X, Locasale, J, Rahal, R, Breitkopf, S, VanderHeiden, M, Spentzos, D, Wu, C-L, Perrimon, N, Cantley, L, Wong, E, and Asara, J. "Abstract LB-255: A mass spectrometry platform to quantitatively profile cancer cell metabolism from cells, tumors, and fixed tissue." Cancer Research 71, no. 8 Supplement (April 15, 2011). Full Text
  - Sasaki, AT, Carracedo, A, Locasale, JW, Anastasiou, D, Takeuchi, K, Kahoud, ER, Haviv, S, Asara, JM, Pandolfi, PP, and Cantley, LC. "Ubiquitination of K-Ras enhances activation and facilitates binding to select downstream effectors." Science Signaling 4, no. 163 (March 8, 2011): ra13-null. Full Text
  - Vander Heiden, MG, Lunt, SY, Dayton, TL, Fiske, BP, Israelsen, WJ, Mattaini, KR, Vokes, NI, Stephanopoulos, G, Cantley, LC, Metallo, CM, and Locasale, JW. "Metabolic pathway alterations that support cell proliferation." Cold Spring Harbor Symposia on Quantitative Biology 76 (January 2011): 325-334. (Review) Full Text
  - Locasale, JW, Vander Heiden, MG, and Cantley, LC. "Rewiring of glycolysis in cancer cell metabolism." Cell cycle (Georgetown, Tex.) 9, no. 21 (November 7, 2010): 4253-. Full Text
  - Vander Heiden, MG, Locasale, JW, Swanson, KD, Sharfi, H, Heffron, GJ, Amador-Noguez, D, Christofk, HR, Wagner, G, Rabinowitz, JD, Asara, JM, and Cantley, LC. "Evidence for an alternative glycolytic pathway in rapidly proliferating cells." Science (New York, N.Y.) 329, no. 5998 (September 2010): 1492-1499. Full Text
  - Yang, X, Rahal, R, Locasale, J, Song, S, Cantley, L, Wong, E, Perrimon, N, Vander Heiden, M, and Asara, J. "A Mass Spectrometry Platform to Quantitatively Profile Cancer Cell Metabolism from Cell Lines to Tissues." Journal of Biomolecular Techniques : Jbt 21, no. 3 Suppl (September 2010): S39-S40.
  - Prisic, S, Dankwa, S, Schwartz, D, Chou, MF, Locasale, JW, Kang, C-M, Bemis, G, Church, GM, Steen, H, and Husson, RN. "Extensive phosphorylation with overlapping specificity by Mycobacterium tuberculosis serine/threonine protein kinases." Proceedings of the National Academy of Sciences of the United States of America 107, no. 16 (April 5, 2010): 7521-7526. Full Text
  - Locasale, JW, and Cantley, LC. "Altered metabolism in cancer." Bmc Biology 8 (January 2010): 88-null. Full Text
  - Locasale, JW, Cantley, LC, and Vander Heiden, MG. "Cancer's insatiable appetite." Nature biotechnology 27, no. 10 (October 2009): 916-917. Full Text
  - Locasale, JW, and Wolf-Yadlin, A. "Maximum entropy reconstructions of dynamic signaling networks from quantitative proteomics data." Plos One 4, no. 8 (August 26, 2009): e6522-null. Full Text
  - Locasale, JW, Napoli, AA, Chen, S, Berman, HM, and Lawson, CL. "Signatures of protein-DNA recognition in free DNA binding sites." Journal of molecular biology 386, no. 4 (March 2009): 1054-1065. Full Text
  - Locasale, JW. "Signal duration and the time scale dependence of signal integration in biochemical pathways." Bmc Systems Biology 2 (December 17, 2008): 108-null. Full Text
  - Locasale, JW. "Three-state kinetic mechanism for scaffold-mediated signal transduction." Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics 78, no. 5 Pt 1 (November 21, 2008): 051921-null. Full Text
  - Locasale, JW, and Chakraborty, AK. "Regulation of signal duration and the statistical dynamics of kinase activation by scaffold proteins." PLoS computational biology 4, no. 6 (June 27, 2008): e1000099-. Full Text
  - Locasale, JW, and Chakraborty, AK. "Importance of signal duration and the time scale dependence of signal integration in biochemical networks." FASEB JOURNAL 22 (April 2008). Link to Item
  - Locasale, JW. "Allovalency revisited: an analysis of multisite phosphorylation and substrate rebinding." The Journal of chemical physics 128, no. 11 (March 2008): 115106-. Full Text
  - Locasale, JW. "Scaffold proteins tune the regulatory properties of protein kinase cascades." ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 234 (August 19, 2007). Link to Item
  - Locasale, JW, Shaw, AS, and Chakraborty, AK. "Scaffold proteins confer diverse regulatory properties to protein kinase cascades." Proceedings of the National Academy of Sciences of the United States of America 104, no. 33 (August 8, 2007): 13307-13312. Full Text
  - Čemerski, S, Das, J, Locasale, J, Arnold, P, Giurisato, E, Markiewicz, MA, Fremont, D, Allen, PM, Chakraborty, AK, and Shaw, AS. "The Stimulatory Potency of T Cell Antigens Is Influenced by the Formation of the Immunological Synapse." Immunity 26, no. 3 (March 23, 2007): 345-355. Full Text
  - Cemerski, S, Das, J, Locasale, J, Arnold, P, Giurisato, E, Markiewicz, MA, Fremont, D, Allen, PM, Chakraborty, AK, and Shaw, AS. "The stimulatory potency of T cell antigens is influenced by the formation of the immunological synapse." Immunity 26, no. 3 (March 8, 2007): 345-355. Full Text
  - Locasale, JW. "Computational investigations into the origins of short-term biochemical memory in T cell activation." PloS one 2, no. 7 (January 2007): e627-. Full Text
- Book Sections
  - Anastasiou, D, Locasale, JW, and Vander Heiden, MG. "Cancer metabolism." In Systems Biology of Cancer, 295-308. January 1, 2015. Full Text
  - Patnaik, A, Locasale, JW, and Cantley, LC. "Cancer cell metabolism." In Insulin-like Growth Factors and Cancer: From Basic Biology to Therapeutics, 245-261. January 1, 2012. Full Text
- Conference Papers
  - Garcia, JN, Bagwell, J, Njaine, B, Norman, J, Levic, D, Wopat, S, Miller, S, Liu, X, Locasale, J, Stainier, D, and Bagnat, M. "Sheath Cell Invasion and Trans-differentiation Repair Mechanical Damage Caused by Loss of Caveolae in the Zebrafish Notochord." Annual Joint Meeting of the American-Society-for-Cell-Biology and the European-Molecular-Biology-Organization (ASCB/EMBO). Philadelphia, PA. December 2, 2017 - December 6, 2017.: AMER SOC CELL BIOLOGY, January 1, 2017. Link to Item
  - Valcarcel, L, Torrano, V, Cortazar, AR, Liu, X, Urosevic, J, Castillo, M, Morciano, G, Graupera, M, Pandya, P, Unda-Urzaiz, M, Schultz, N, Aransay, A, Sanz-Moreno, V, Barrio, R, Velasco, G, Pinton, P, Cordon-Cardo, C, Gomis, RR, Locasale, J, and Carracedo, A. "Transcriptional regulation of prostate cancer metabolism." : ELSEVIER SCI LTD, July 1, 2016. Link to Item
  - O-Sullivan, I, Sibai, Z, Zhang, W, Locasale, J, Mashek, DG, and Unterman, TG. "Fox01 Promotes Glucose Intolerance in Liver-specific Insulin Receptor Knockout (LIRKO) Mice by Regulating ATGL-dependent Lipo lysis and Fatty Acid Oxidation." June 2016. Link to Item
  - Liu, X, Lengyel, E, Romero, I, and Locasale, J. "Metformin acts to disrupt mitochondrial-associated metabolic homeostasis in human cancer." : AMER CHEMICAL SOC, August 16, 2015. Link to Item
  - Romero, IL, Liu, X, Mitra, AK, Lengyel, E, and Locasale, JW. "Abstract POSTER-TECH-1123: Advancing metformin as therapeutic for ovarian cancer: metabolomic profiling of mouse ovarian tumors identifies metformin-induced global metabolic changes." : American Association for Cancer Research (AACR), August 15, 2015. Full Text
  - Campbell, SL, Baker, R, Lewis, S, Sasaki, A, Wilkerson, EM, Locasale, J, Cantley, LC, Kuhlman, B, and Dohlman, H. "Ras Activity Regulation by Monoubiquitination." April 2013. Link to Item
  - Shestov, A, Mancuso, A, Locasale, JW, and Glickson, JD. "Human melanoma metabolic network analysis with combined 13C NMR/bioreactor technique: testing the Warburg effect." April 2013. Link to Item
  - Locasale, JW, Chakraborty, AK, and Shaw, A. "Scaffold proteins confer diverse regulatory properties to protein kinase cascades." April 2007. Link to Item
  - Castner, EW, Lee, BJ, Diken, EG, Shirota, H, DeRitter, M, Wiewior, PP, and Locasale, JW. "Friction, dynamics, and length scales in hydrophilic polymers." March 2003. Link to Item
Teaching & Mentoring
Recent Courses

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.

Education, Training, & Certifications

Duke Appointment History

In the News

Selected Publications

Academic Articles

Book Sections

Conference Papers

Recent Courses