Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., Massachusetts Institute of Technology 2008
  • B.A., Rutgers University New Brunswick 2003
• 

  Duke Appointment History

  • Assistant Professor of Pharmacology & Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2015 - 2018
• Recognition
• 

  In the News

  • SEP 17, 2017

    Duke Health News

    Natural Molecule Appears to Shut Off Cancer Cells Energy Source
• Research
• 

  External Relationships

  • 5am ventures
  • Adjunct Professor North Carolina State U (unpaid)
  • American Association for Cancer Research
  • American Cancer Society
  • Bridge Bio
  • Cell Stress - editorial board
  • Clarion Healthcare
  • Danube Epigenetics Webinair Series - FEBS
  • Digatalis Ventures
  • Enara bio
  • Francis Crick Institute - London UK speaker
  • Geistlich Pharmaceuticals
  • Institute for Stem Cell Science & Regenerative Medicine (inStem), Bangalore, India
  • International Society for Cancer Metabolism
  • Israel Science Foundation
  • Keystone Symposia
  • Kika, Children Cancer-free Foundation - Netherlands
  • NIH
  • Nanocare Technologies
  • Nestle Health Sciences
  • Oncotarget - editorial board
  • Petri Biologicals
  • Plos biology - editorial board
  • Raphael Pharmaceuticals
  • Restoration Foodworks
  • Society for Neurooncology
  • Southern University of Science and Technology (SUSTech)
  • Swiss Federal Institute of Technology Lausanne
  • Tsinghua University
  • UC Irvine
  • United Health Group Research and Developement
  • University of Helsinki
  • University of Lausanne
  • University of Sydney
  • University of Toronto
  • Xian Jiaotong University
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Schmidt, Daniel R., Rutulkumar Patel, David G. Kirsch, Caroline A. Lewis, Matthew G. Vander Heiden, and Jason W. Locasale. “Metabolomics in cancer research and emerging applications in clinical oncology.” Ca Cancer J Clin 71, no. 4 (July 2021): 333–58. https://doi.org/10.3322/caac.21670.
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    • Dai, Ziwei, and Jason Locasale. “Amino acid variability, tradeoffs and optimality in human diet,” June 17, 2021. https://doi.org/10.1101/2021.06.16.448627.
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    • Xu, Lingfan, Yu Yin, Yanjing Li, Xufeng Chen, Yan Chang, Hong Zhang, Juan Liu, et al. “A glutaminase isoform switch drives therapeutic resistance and disease progression of prostate cancer.” Proc Natl Acad Sci U S A 118, no. 13 (March 30, 2021). https://doi.org/10.1073/pnas.2012748118.
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    • Mason, Joshua A., Jordan A. Cockfield, Daniel J. Pape, Hannah Meissner, Michael T. Sokolowski, Taylor C. White, José C. Valentín López, et al. “SGK1 signaling promotes glucose metabolism and survival in extracellular matrix detached cells.” Cell Rep 34, no. 11 (March 16, 2021): 108821. https://doi.org/10.1016/j.celrep.2021.108821.
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    • Healey, Diana C Contreras, Jacqueline Y. Cephus, Sierra M. Barone, Nowrin U. Chowdhury, Debolanle O. Dahunsi, Matthew Z. Madden, Xiang Ye, et al. “Targeting In Vivo Metabolic Vulnerabilities of Th2 and Th17 Cells Reduces Airway Inflammation.” J Immunol 206, no. 6 (March 15, 2021): 1127–39. https://doi.org/10.4049/jimmunol.2001029.
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    • Gu, Chunfang, Juan Liu, Xiaojing Liu, Haibo Zhang, Ji Luo, Huanchen Wang, Jason W. Locasale, and Stephen B. Shears. “Metabolic supervision by PPIP5K, an inositol pyrophosphate kinase/phosphatase, controls proliferation of the HCT116 tumor cell line.” Proc Natl Acad Sci U S A 118, no. 10 (March 9, 2021). https://doi.org/10.1073/pnas.2020187118.
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    • Xiao, Zhengtao, and Jason W. Locasale. “Epigenomic links from metabolism-methionine and chromatin architecture.” Curr Opin Chem Biol 63 (March 2, 2021): 11–18. https://doi.org/10.1016/j.cbpa.2021.01.011.
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    • Nam, Hyeyoung, Anirban Kundu, Suman Karki, Garrett Brinkley, Darshan Chandrashekar, Richard Kirkman, Juan Liu, et al. “TGF-β signaling suppresses TCA cycle metabolism in renal cancer,” February 19, 2021. https://doi.org/10.1101/2021.02.19.429599.
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    • Allen, Annamarie E., and Jason W. Locasale. “Metabolomics: insights into plant-based diets.” Embo Mol Med 13, no. 2 (February 5, 2021): e13568. https://doi.org/10.15252/emmm.202013568.
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    • Duan, Likun, Daniel Cooper, Grace Scheidemantle, Jason Locasale, David Kirsch, and Xiaojing Liu. “13C tracer analysis identifies extensive recycling of endogenous CO2 in vivo,” February 5, 2021. https://doi.org/10.1101/2021.02.04.429777.
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    • Hwang, Inah, Hiroki Uchida, Ziwei Dai, Fei Li, Teresa Sanchez, Jason W. Locasale, Lewis C. Cantley, Hongwu Zheng, and Jihye Paik. “Cellular stress signaling activates type-I IFN response through FOXO3-regulated lamin posttranslational modification.” Nat Commun 12, no. 1 (January 28, 2021): 640. https://doi.org/10.1038/s41467-020-20839-0.
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    • Pan, Christopher, and Jason W. Locasale. “Targeting metabolism to influence aging.” Science 371, no. 6526 (January 15, 2021): 234–35. https://doi.org/10.1126/science.abf6368.
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    • Quek, Lake-Ee, James R. Krycer, Satoshi Ohno, Katsuyuki Yugi, Daniel J. Fazakerley, Richard Scalzo, Sarah D. Elkington, et al. “Erratum: Dynamic 13C Flux Analysis Captures the Reorganization of Adipocyte Glucose Metabolism in Response to Insulin.” Iscience 23, no. 12 (December 18, 2020): 101786. https://doi.org/10.1016/j.isci.2020.101786.
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    • Liao, Chengheng, Cherise Ryan Glodowski, Cheng Fan, Juan Liu, Kevin Raynard Mott, Jason Locasale, Samuel McBrayer, Ralph DeBerardinis, Charles Perou, and Qing Zhang. “Integrated Metabolic Profiling and Gene Expression Analysis Reveals Therapeutic Modalities in Breast Cancer,” December 9, 2020. https://doi.org/10.21203/rs.3.rs-117384/v1.
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    • Dai, Ziwei, Vijyendra Ramesh, and Jason W. Locasale. “The evolving metabolic landscape of chromatin biology and epigenetics.” Nat Rev Genet 21, no. 12 (December 2020): 737–53. https://doi.org/10.1038/s41576-020-0270-8.
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    • Dai, Ziwei, Vijyendra Ramesh, and Jason W. Locasale. “Author Correction: The evolving metabolic landscape of chromatin biology and epigenetics.” Nat Rev Genet 21, no. 12 (December 2020): 782. https://doi.org/10.1038/s41576-020-00291-y.
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    • Yu, Yi-Ru, Hana Imrichova, Haiping Wang, Tung Chao, Zhengtao Xiao, Min Gao, Marcela Rincon-Restrepo, et al. “Disturbed mitochondrial dynamics in CD8+ TILs reinforce T cell exhaustion.” Nat Immunol 21, no. 12 (December 2020): 1540–51. https://doi.org/10.1038/s41590-020-0793-3.
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    • Brinkley, Garrett, Hyeyoung Nam, Eunhee Shim, Richard Kirkman, Anirban Kundu, Suman Karki, Yasaman Heidarian, et al. “Teleological role of L-2-hydroxyglutarate dehydrogenase in the kidney.” Dis Model Mech 13, no. 11 (November 27, 2020). https://doi.org/10.1242/dmm.045898.
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    • Gut, Philipp, Sanna Matilainen, Jesse G. Meyer, Pieti Pällijeff, Joy Richard, Christopher J. Carroll, Liliya Euro, et al. “SUCLA2 mutations cause global protein succinylation contributing to the pathomechanism of a hereditary mitochondrial disease.” Nat Commun 11, no. 1 (November 23, 2020): 5927. https://doi.org/10.1038/s41467-020-19743-4.
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    • Bose, Shree, Annamarie E. Allen, and Jason W. Locasale. “The Molecular Link from Diet to Cancer Cell Metabolism.” Mol Cell 80, no. 3 (November 5, 2020): 554. https://doi.org/10.1016/j.molcel.2020.10.006.
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    • Liao, Chengheng, Yang Zhang, Cheng Fan, Laura E. Herring, Juan Liu, Jason W. Locasale, Mamoru Takada, et al. “Identification of BBOX1 as a Therapeutic Target in Triple-Negative Breast Cancer.” Cancer Discov 10, no. 11 (November 2020): 1706–21. https://doi.org/10.1158/2159-8290.CD-20-0288.
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    • Liu, Shiyu, Ziwei Dai, Daniel E. Cooper, David G. Kirsch, and Jason W. Locasale. “Quantitative Analysis of the Physiological Contributions of Glucose to the TCA Cycle.” Cell Metab 32, no. 4 (October 6, 2020): 619-628.e21. https://doi.org/10.1016/j.cmet.2020.09.005.
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    • Deblois, Geneviève, Seyed Ali Madani Tonekaboni, Giacomo Grillo, Constanza Martinez, Yunchi Ingrid Kao, Felicia Tai, Ilias Ettayebi, et al. “Epigenetic Switch-Induced Viral Mimicry Evasion in Chemotherapy-Resistant Breast Cancer.” Cancer Discov 10, no. 9 (September 2020): 1312–29. https://doi.org/10.1158/2159-8290.CD-19-1493.
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    • Hoxhaj, Gerta, Jason W. Locasale, and Issam Ben-Sahra. “A spoonful of DHAP keeps mTORC1 running on sugars.” Nat Metab 2, no. 9 (September 2020): 801–2. https://doi.org/10.1038/s42255-020-0246-1.
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    • Xu, Qing, Yuanyuan Li, Xia Gao, Kai Kang, Jason G. Williams, Lingfeng Tong, Juan Liu, et al. “HNF4α regulates sulfur amino acid metabolism and confers sensitivity to methionine restriction in liver cancer.” Nat Commun 11, no. 1 (August 7, 2020): 3978. https://doi.org/10.1038/s41467-020-17818-w.
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    • Bose, Shree, Annamarie E. Allen, and Jason W. Locasale. “The Molecular Link from Diet to Cancer Cell Metabolism.” Mol Cell 78, no. 6 (June 18, 2020): 1034–44. https://doi.org/10.1016/j.molcel.2020.05.018.
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    • Britt, Emily C., Steven V. John, Jason W. Locasale, and Jing Fan. “Metabolic regulation of epigenetic remodeling in immune cells.” Curr Opin Biotechnol 63 (June 2020): 111–17. https://doi.org/10.1016/j.copbio.2019.12.008.
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    • Ke, Wenfan, James A. Saba, Cong-Hui Yao, Michael A. Hilzendeger, Anna Drangowska-Way, Chintan Joshi, Vinod K. Mony, et al. “Dietary serine-microbiota interaction enhances chemotherapeutic toxicity without altering drug conversion.” Nature Communications 11, no. 1 (May 22, 2020): 2587. https://doi.org/10.1038/s41467-020-16220-w.
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    • Dai, Ziwei, and Jason W. Locasale. “Cooperative virus propagation underlies COVID-19 transmission dynamics.” Medrxiv, May 7, 2020. https://doi.org/10.1101/2020.05.05.20092361.
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    • Ramesh, Vijyendra, and Jason W. Locasale. “A reactive metabolite as an immune suppressant.” Nat Immunol 21, no. 5 (May 2020): 497–98. https://doi.org/10.1038/s41590-020-0664-y.
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    • Fox, Douglas B., Nina Marie G. Garcia, Brock J. McKinney, Ryan Lupo, Laura C. Noteware, Rachel Newcomb, Juan Liu, Jason W. Locasale, Matthew D. Hirschey, and James V. Alvarez. “NRF2 activation promotes the recurrence of dormant tumour cells through regulation of redox and nucleotide metabolism.” Nat Metab 2, no. 4 (April 2020): 318–34. https://doi.org/10.1038/s42255-020-0191-z.
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    • Lin, Kevin H., Justine C. Rutter, Abigail Xie, Bryann Pardieu, Emily T. Winn, Reinaldo Dal Bello, Antoine Forget, et al. “Using antagonistic pleiotropy to design a chemotherapy-induced evolutionary trap to target drug resistance in cancer.” Nat Genet 52, no. 4 (April 2020): 408–17. https://doi.org/10.1038/s41588-020-0590-9.
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    • Sanderson, Sydney, Zhengtao Xiao, Amy Wisdom, Shree Bose, Maria Liberti, Michael Reid, Emily Hocke, Simon Gregory, David Kirsch, and Jason Locasale. “The Na+/K+ ATPase Regulates Glycolysis and Modifies Immune Metabolism in Tumors,” April 2020. https://doi.org/10.1101/2020.03.31.018739.
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    • Shats, Igor, Jason G. Williams, Juan Liu, Mikhail V. Makarov, Xiaoyue Wu, Fred B. Lih, Leesa J. Deterding, et al. “Bacteria Boost Mammalian Host NAD Metabolism by Engaging the Deamidated Biosynthesis Pathway.” Cell Metab 31, no. 3 (March 3, 2020): 564-579.e7. https://doi.org/10.1016/j.cmet.2020.02.001.
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    • Davis, Ryan T., Kerrigan Blake, Dennis Ma, Mari B Ishak Gabra, Grace A. Hernandez, Anh T. Phung, Ying Yang, et al. “Transcriptional diversity and bioenergetic shift in human breast cancer metastasis revealed by single-cell RNA sequencing.” Nat Cell Biol 22, no. 3 (March 2020): 310–20. https://doi.org/10.1038/s41556-020-0477-0.
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    • Liberti, Maria V., and Jason W. Locasale. “Histone Lactylation: A New Role for Glucose Metabolism.” Trends Biochem Sci 45, no. 3 (March 2020): 179–82. https://doi.org/10.1016/j.tibs.2019.12.004.
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    • Quek, Lake-Ee, James R. Krycer, Satoshi Ohno, Katsuyuki Yugi, Daniel J. Fazakerley, Richard Scalzo, Sarah D. Elkington, et al. “Dynamic 13C Flux Analysis Captures the Reorganization of Adipocyte Glucose Metabolism in Response to Insulin.” Iscience 23, no. 2 (February 21, 2020): 100855. https://doi.org/10.1016/j.isci.2020.100855.
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    • Rumala, Courtney Zasha, Juan Liu, Jason Wei Locasale, Barbara Ellen Corkey, Jude Thaddeus Deeney, and Lucia Egydio Rameh. “Exposure of Pancreatic β-Cells to Excess Glucose Results in Bimodal Activation of mTORC1 and mTOR-Dependent Metabolic Acceleration.” Iscience 23, no. 2 (February 21, 2020): 100858. https://doi.org/10.1016/j.isci.2020.100858.
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    • Tang, Shuang, Xiaoling Li, and Jason W. Locasale. “Dietary Methionine in T Cell Biology and Autoimmune Disease.” Cell Metab 31, no. 2 (February 4, 2020): 211–12. https://doi.org/10.1016/j.cmet.2020.01.007.
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    • Liberti, Maria V., Annamarie E. Allen, Vijyendra Ramesh, Ziwei Dai, Katherine R. Singleton, Zufeng Guo, Jun O. Liu, Kris C. Wood, and Jason W. Locasale. “Evolved resistance to partial GAPDH inhibition results in loss of the Warburg effect and in a different state of glycolysis.” J Biol Chem 295, no. 1 (January 3, 2020): 111–24. https://doi.org/10.1074/jbc.RA119.010903.
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    • Guo, Zufeng, Zhiqiang Cheng, Jingxin Wang, Wukun Liu, Hanjing Peng, Yuefan Wang, AV Subba Rao, et al. “Discovery of a Potent GLUT Inhibitor from a Library of Rapafucins by Using 3D Microarrays.” Angew Chem Int Ed Engl 58, no. 48 (November 25, 2019): 17158–62. https://doi.org/10.1002/anie.201905578.
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    • Tabilas, Cybelle, Jocelyn Wang, Xiaojing Liu, Jason W. Locasale, Norah L. Smith, and Brian D. Rudd. “Cutting Edge: Elevated Glycolytic Metabolism Limits the Formation of Memory CD8+ T Cells in Early Life.” J Immunol 203, no. 10 (November 15, 2019): 2571–76. https://doi.org/10.4049/jimmunol.1900426.
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    • Zurlo, Giada, Xijuan Liu, Mamoru Takada, Cheng Fan, Jeremy M. Simon, Travis S. Ptacek, Javier Rodriguez, et al. “Prolyl hydroxylase substrate adenylosuccinate lyase is an oncogenic driver in triple negative breast cancer.” Nat Commun 10, no. 1 (November 15, 2019): 5177. https://doi.org/10.1038/s41467-019-13168-4.
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    • Liu, Shiyu, Ziwei Dai, Daniel Cooper, David Kirsch, and Jason Locasale. “Quantitative analysis of the physiological contributions of glucose to the TCA cycle,” November 13, 2019. https://doi.org/10.1101/840538.
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    • Langston, P Kent, Aya Nambu, Jonathan Jung, Munehiko Shibata, H Ibrahim Aksoylar, Jiahui Lei, Peining Xu, et al. “Author Correction: Glycerol phosphate shuttle enzyme GPD2 regulates macrophage inflammatory responses.” Nat Immunol 20, no. 11 (November 2019): 1555. https://doi.org/10.1038/s41590-019-0517-8.
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    • Sanderson, Sydney M., Xia Gao, Ziwei Dai, and Jason W. Locasale. “Methionine metabolism in health and cancer: a nexus of diet and precision medicine.” Nat Rev Cancer 19, no. 11 (November 2019): 625–37. https://doi.org/10.1038/s41568-019-0187-8.
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    • Bose, Shree, Vijyendra Ramesh, and Jason W. Locasale. “Acetate Metabolism in Physiology, Cancer, and Beyond.” Trends Cell Biol 29, no. 9 (September 2019): 695–703. https://doi.org/10.1016/j.tcb.2019.05.005.
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    • Langston, P Kent, Aya Nambu, Jonathan Jung, Munehiko Shibata, H Ibrahim Aksoylar, Jiahui Lei, Peining Xu, et al. “Glycerol phosphate shuttle enzyme GPD2 regulates macrophage inflammatory responses.” Nat Immunol 20, no. 9 (September 2019): 1186–95. https://doi.org/10.1038/s41590-019-0453-7.
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    • Xiao, Zhengtao, Ziwei Dai, and Jason W. Locasale. “Metabolic landscape of the tumor microenvironment at single cell resolution.” Nat Commun 10, no. 1 (August 21, 2019): 3763. https://doi.org/10.1038/s41467-019-11738-0.
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    • Gao, Xia, Sydney M. Sanderson, Ziwei Dai, Michael A. Reid, Daniel E. Cooper, Min Lu, John P. Richie, et al. “Dietary methionine influences therapy in mouse cancer models and alters human metabolism.” Nature 572, no. 7769 (August 2019): 397–401. https://doi.org/10.1038/s41586-019-1437-3.
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    • Park, Sunghee, Rachid Safi, Xiaojing Liu, Robert Baldi, Wen Liu, Juan Liu, Jason W. Locasale, Ching-Yi Chang, and Donald P. McDonnell. “Inhibition of ERRα Prevents Mitochondrial Pyruvate Uptake Exposing NADPH-Generating Pathways as Targetable Vulnerabilities in Breast Cancer.” Cell Rep 27, no. 12 (June 18, 2019): 3587-3601.e4. https://doi.org/10.1016/j.celrep.2019.05.066.
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    • Sanderson, Sydney M., Peter G. Mikhael, Vijyendra Ramesh, Ziwei Dai, and Jason W. Locasale. “Nutrient availability shapes methionine metabolism in p16/MTAP-deleted cells.” Sci Adv 5, no. 6 (June 2019): eaav7769. https://doi.org/10.1126/sciadv.aav7769.
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    • Ma, Hong, Shuo Yu, Xiaojing Liu, Yingao Zhang, Thomas Fakadej, Ziqing Liu, Chaoying Yin, et al. “Lin28a Regulates Pathological Cardiac Hypertrophic Growth Through Pck2-Mediated Enhancement of Anabolic Synthesis.” Circulation 139, no. 14 (April 2, 2019): 1725–40. https://doi.org/10.1161/CIRCULATIONAHA.118.037803.
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    • Hart, Peter C., Tatsuyuki Chiyoda, Xiaojing Liu, Melanie Weigert, Marion Curtis, Chun-Yi Chiang, Rachel Loth, et al. “SPHK1 Is a Novel Target of Metformin in Ovarian Cancer.” Mol Cancer Res 17, no. 4 (April 2019): 870–81. https://doi.org/10.1158/1541-7786.MCR-18-0409.
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    • Lee, Jiyoung, Ali E. Yesilkanal, Joseph P. Wynne, Casey Frankenberger, Juan Liu, Jielin Yan, Mohamad Elbaz, et al. “Effective breast cancer combination therapy targeting BACH1 and mitochondrial metabolism.” Nature 568, no. 7751 (April 2019): 254–58. https://doi.org/10.1038/s41586-019-1005-x.
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    • Vodnala, Suman Kumar, Robert Eil, Rigel J. Kishton, Madhusudhanan Sukumar, Tori N. Yamamoto, Ngoc-Han Ha, Ping-Hsien Lee, et al. “T cell stemness and dysfunction in tumors are triggered by a common mechanism.” Science 363, no. 6434 (March 29, 2019). https://doi.org/10.1126/science.aau0135.
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    • Sinclair, Linda V., Andrew Jm Howden, Alejandro Brenes, Laura Spinelli, Jens L. Hukelmann, Andrew N. Macintyre, Xiaojing Liu, et al. “Antigen receptor control of methionine metabolism in T cells.” Elife 8 (March 27, 2019). https://doi.org/10.7554/eLife.44210.
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    • Gao, Xia, Jason W. Locasale, and Michael A. Reid. “Serine and Methionine Metabolism: Vulnerabilities in Lethal Prostate Cancer.” Cancer Cell 35, no. 3 (March 18, 2019): 339–41. https://doi.org/10.1016/j.ccell.2019.02.014.
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    • Yang, Ying, Mari B. Ishak Gabra, Eric A. Hanse, Xazmin H. Lowman, Thai Q. Tran, Haiqing Li, Neta Milman, et al. “MiR-135 suppresses glycolysis and promotes pancreatic cancer cell adaptation to metabolic stress by targeting phosphofructokinase-1.” Nat Commun 10, no. 1 (February 18, 2019): 809. https://doi.org/10.1038/s41467-019-08759-0.
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    • Freemerman, Alex J., Liyang Zhao, Ajeeth K. Pingili, Bin Teng, Alyssa J. Cozzo, Ashley M. Fuller, Amy R. Johnson, et al. “Myeloid Slc2a1-Deficient Murine Model Revealed Macrophage Activation and Metabolic Phenotype Are Fueled by GLUT1.” J Immunol 202, no. 4 (February 15, 2019): 1265–86. https://doi.org/10.4049/jimmunol.1800002.
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    • Cao, Jennifer Yinuo, Aunoy Poddar, Leslie Magtanong, Jennifer H. Lumb, Trevor R. Mileur, Michael A. Reid, Cole M. Dovey, et al. “A Genome-wide Haploid Genetic Screen Identifies Regulators of Glutathione Abundance and Ferroptosis Sensitivity.” Cell Rep 26, no. 6 (February 5, 2019): 1544-1556.e8. https://doi.org/10.1016/j.celrep.2019.01.043.
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    • Gemta, Lelisa F., Peter J. Siska, Marin E. Nelson, Xia Gao, Xiaojing Liu, Jason W. Locasale, Hideo Yagita, et al. “Impaired enolase 1 glycolytic activity restrains effector functions of tumor-infiltrating CD8+ T cells.” Sci Immunol 4, no. 31 (January 25, 2019). https://doi.org/10.1126/sciimmunol.aap9520.
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    • Daniels, Brian P., Sigal B. Kofman, Julian R. Smith, Geoffrey T. Norris, Annelise G. Snyder, Joseph P. Kolb, Xia Gao, et al. “The Nucleotide Sensor ZBP1 and Kinase RIPK3 Induce the Enzyme IRG1 to Promote an Antiviral Metabolic State in Neurons.” Immunity 50, no. 1 (January 15, 2019): 64-76.e4. https://doi.org/10.1016/j.immuni.2018.11.017.
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    • Curtis, Marion, Hilary A. Kenny, Bradley Ashcroft, Abir Mukherjee, Alyssa Johnson, Yilin Zhang, Ynes Helou, et al. “Fibroblasts Mobilize Tumor Cell Glycogen to Promote Proliferation and Metastasis.” Cell Metab 29, no. 1 (January 8, 2019): 141-155.e9. https://doi.org/10.1016/j.cmet.2018.08.007.
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    • May, Jasmine L., Fotini M. Kouri, Lisa A. Hurley, Juan Liu, Serena Tommasini-Ghelfi, Yanrong Ji, Peng Gao, et al. “IDH3α regulates one-carbon metabolism in glioblastoma.” Sci Adv 5, no. 1 (January 2019): eaat0456. https://doi.org/10.1126/sciadv.aat0456.
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    • Dai, Ziwei, and Jason W. Locasale. “Thermodynamic constraints on the regulation of metabolic fluxes.” J Biol Chem 293, no. 51 (December 21, 2018): 19725–39. https://doi.org/10.1074/jbc.RA118.004372.
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    • Reid, Michael A., Annamarie E. Allen, Shiyu Liu, Maria V. Liberti, Pei Liu, Xiaojing Liu, Ziwei Dai, et al. “Serine synthesis through PHGDH coordinates nucleotide levels by maintaining central carbon metabolism.” Nat Commun 9, no. 1 (December 21, 2018): 5442. https://doi.org/10.1038/s41467-018-07868-6.
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    • Johnson, Marc O., Melissa M. Wolf, Matthew Z. Madden, Gabriela Andrejeva, Ayaka Sugiura, Diana C. Contreras, Damian Maseda, et al. “Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism.” Cell 175, no. 7 (December 13, 2018): 1780-1795.e19. https://doi.org/10.1016/j.cell.2018.10.001.
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    • Sanderson, Sydney M., and Jason W. Locasale. “Revisiting the Warburg Effect: Some Tumors Hold Their Breath.” Cell Metab 28, no. 5 (November 6, 2018): 669–70. https://doi.org/10.1016/j.cmet.2018.10.011.
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    • Stone, Oliver A., Mohamed El-Brolosy, Kerstin Wilhelm, Xiaojing Liu, Ana M. Romão, Elisabetta Grillo, Jason K. H. Lai, et al. “Loss of pyruvate kinase M2 limits growth and triggers innate immune signaling in endothelial cells.” Nat Commun 9, no. 1 (October 9, 2018): 4077. https://doi.org/10.1038/s41467-018-06406-8.
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    • Liu, Xiaojing, Daniel E. Cooper, Ahmad A. Cluntun, Marc O. Warmoes, Steven Zhao, Michael A. Reid, Juan Liu, et al. “Acetate Production from Glucose and Coupling to Mitochondrial Metabolism in Mammals.” Cell 175, no. 2 (October 4, 2018): 502-513.e13. https://doi.org/10.1016/j.cell.2018.08.040.
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    • Bechard, Matthew E., Anna E. Word, Amanda V. Tran, Xiaojing Liu, Jason W. Locasale, and Oliver G. McDonald. “Pentose conversions support the tumorigenesis of pancreatic cancer distant metastases.” Oncogene 37, no. 38 (September 2018): 5248–56. https://doi.org/10.1038/s41388-018-0346-5.
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    • Gamble, L. J., C. W. Frye, C. M. Hansen, J. W. Locasale, X. Liu, M. S. Davis, and J. J. Wakshlag. “Serum metabolomics of Alaskan sled dogs during endurance racing.” Comparative Exercise Physiology 14, no. 3 (September 1, 2018): 149–59. https://doi.org/10.3920/CEP180010.
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    • Chapman, Nicole M., Hu Zeng, Thanh-Long M. Nguyen, Yanyan Wang, Peter Vogel, Yogesh Dhungana, Xiaojing Liu, Geoffrey Neale, Jason W. Locasale, and Hongbo Chi. “mTOR coordinates transcriptional programs and mitochondrial metabolism of activated Treg subsets to protect tissue homeostasis.” Nat Commun 9, no. 1 (May 29, 2018): 2095. https://doi.org/10.1038/s41467-018-04392-5.
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    • Dai, Ziwei, Samantha J. Mentch, Xia Gao, Sailendra N. Nichenametla, and Jason W. Locasale. “Methionine metabolism influences genomic architecture and gene expression through H3K4me3 peak width.” Nat Commun 9, no. 1 (May 16, 2018): 1955. https://doi.org/10.1038/s41467-018-04426-y.
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    • Sanderson, Sydney, Peter Mikhael, Ziwei Dai, and Jason Locasale. “Environmental factors shape methionine metabolism in p16/MTAP deleted cells,” May 2, 2018. https://doi.org/10.1101/313288.
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    • Gao, Xia, Katie Lee, Michael A. Reid, Sydney M. Sanderson, Chuping Qiu, Siqi Li, Juan Liu, and Jason W. Locasale. “Serine Availability Influences Mitochondrial Dynamics and Function through Lipid Metabolism.” Cell Rep 22, no. 13 (March 27, 2018): 3507–20. https://doi.org/10.1016/j.celrep.2018.03.017.
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    • Allen, Annamarie E., and Jason W. Locasale. “Glucose Metabolism in Cancer: The Saga of Pyruvate Kinase Continues.” Cancer Cell 33, no. 3 (March 12, 2018): 337–39. https://doi.org/10.1016/j.ccell.2018.02.008.
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    • Hwang, Inah, Hwanhee Oh, Evan Santo, Do-Yeon Kim, John W. Chen, Roderick T. Bronson, Jason W. Locasale, et al. “FOXO protects against age-progressive axonal degeneration.” Aging Cell 17, no. 1 (February 2018). https://doi.org/10.1111/acel.12701.
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    • Zhao, Fei, Christine Xiao, Kathy S. Evans, Tbalamayooran Theivanthiran, Nicholas DeVito, Alisha Holtzhausen, Juan Liu, et al. “Paracrine Wnt5a-β-Catenin Signaling Triggers a Metabolic Program that Drives Dendritic Cell Tolerization.” Immunity 48, no. 1 (January 16, 2018): 147-160.e7. https://doi.org/10.1016/j.immuni.2017.12.004.
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    • Dai, Ziwei, Samantha Mentch, Xia Gao, Sailendra Nichenametla, and Jason Locasale. “Methionine metabolism influences the genomic architecture of H3K4me3 with the link to gene expression encoded in peak width,” January 5, 2018. https://doi.org/10.1101/243196.
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    • Liu, Xiaojing, Daniel E. Cooper, Ahmad A. Cluntun, Marc O. Warmoes, Steven Zhao, Michael A. Reid, Juan Liu, Kathryn E. Wellen, David G. Kirsch, and Jason W. Locasale. “De Novo Acetate Production is Coupled to Central Carbon Metabolism in Mammals,” 2018.
    • Lu, Min, Sydney M. Sanderson, Amelia Zessin, Kathleen A. Ashcraft, Lee W. Jones, Mark W. Dewhirst, Jason W. Locasale, and David S. Hsu. “Exercise inhibits tumor growth and central carbon metabolism in patient-derived xenograft models of colorectal cancer.” Cancer Metab 6 (2018): 14. https://doi.org/10.1186/s40170-018-0190-7.
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    • Hershberger, Kathleen A., Dennis M. Abraham, Angelical S. Martin, Lan Mao, Juan Liu, Hongbo Gu, Jason W. Locasale, and Matthew D. Hirschey. “Sirtuin 5 is required for mouse survival in response to cardiac pressure overload.” J Biol Chem 292, no. 48 (December 1, 2017): 19767–81. https://doi.org/10.1074/jbc.M117.809897.
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    • Reid, Michael A., Jihye Paik, and Jason W. Locasale. “A Missing Link to Vitamin B12 Metabolism.” Cell 171, no. 4 (November 2, 2017): 736–37. https://doi.org/10.1016/j.cell.2017.10.030.
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    • Tang, Shuang, Yi Fang, Gang Huang, Xiaojiang Xu, Elizabeth Padilla-Banks, Wei Fan, Qing Xu, et al. “Methionine metabolism is essential for SIRT1-regulated mouse embryonic stem cell maintenance and embryonic development.” Embo J 36, no. 21 (November 2, 2017): 3175–93. https://doi.org/10.15252/embj.201796708.
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    • Reid, Michael A., Ziwei Dai, and Jason W. Locasale. “The impact of cellular metabolism on chromatin dynamics and epigenetics.” Nat Cell Biol 19, no. 11 (November 2017): 1298–1306. https://doi.org/10.1038/ncb3629.
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    • Liberti, Maria V., Ziwei Dai, Suzanne E. Wardell, Joshua A. Baccile, Xiaojing Liu, Xia Gao, Robert Baldi, et al. “A Predictive Model for Selective Targeting of the Warburg Effect through GAPDH Inhibition with a Natural Product.” Cell Metab 26, no. 4 (October 3, 2017): 648-659.e8. https://doi.org/10.1016/j.cmet.2017.08.017.
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    • Dai, Ziwei, and Jason W. Locasale. “Understanding metabolism with flux analysis: From theory to application.” Metab Eng 43, no. Pt B (September 2017): 94–102. https://doi.org/10.1016/j.ymben.2016.09.005.
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    • Cluntun, Ahmad A., Michael J. Lukey, Richard A. Cerione, and Jason W. Locasale. “Glutamine Metabolism in Cancer: Understanding the Heterogeneity.” Trends Cancer 3, no. 3 (March 2017): 169–80. https://doi.org/10.1016/j.trecan.2017.01.005.
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    • Mattocks, Dwight A. L., Samantha J. Mentch, Jelena Shneyder, Gene P. Ables, Dongxiao Sun, John P. Richie, Jason W. Locasale, and Sailendra N. Nichenametla. “Short term methionine restriction increases hepatic global DNA methylation in adult but not young male C57BL/6J mice.” Exp Gerontol 88 (February 2017): 1–8. https://doi.org/10.1016/j.exger.2016.12.003.
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    • Wang, Qian, Maria V. Liberti, Pei Liu, Xiaobing Deng, Ying Liu, Jason W. Locasale, and Luhua Lai. “Rational Design of Selective Allosteric Inhibitors of PHGDH and Serine Synthesis with Anti-tumor Activity.” Cell Chem Biol 24, no. 1 (January 19, 2017): 55–65. https://doi.org/10.1016/j.chembiol.2016.11.013.
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    • Mehrmohamadi, Mahya, Seong Ho Jeong, and Jason W. Locasale. “Molecular features that predict the response to antimetabolite chemotherapies.” Cancer Metab 5 (2017): 8. https://doi.org/10.1186/s40170-017-0170-3.
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    • Salerno, Stephen, Mahya Mehrmohamadi, Maria V. Liberti, Muting Wan, Martin T. Wells, James G. Booth, and Jason W. Locasale. “RRmix: A method for simultaneous batch effect correction and analysis of metabolomics data in the absence of internal standards.” Plos One 12, no. 6 (2017): e0179530. https://doi.org/10.1371/journal.pone.0179530.
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    • Mehrmohamadi, Mahya, Lucas K. Mentch, Andrew G. Clark, and Jason W. Locasale. “Integrative modelling of tumour DNA methylation quantifies the contribution of metabolism.” Nat Commun 7 (December 14, 2016): 13666. https://doi.org/10.1038/ncomms13666.
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    • Liu, Xiaojing, Iris L. Romero, Lacey M. Litchfield, Ernst Lengyel, and Jason W. Locasale. “Metformin Targets Central Carbon Metabolism and Reveals Mitochondrial Requirements in Human Cancers.” Cell Metab 24, no. 5 (November 8, 2016): 728–39. https://doi.org/10.1016/j.cmet.2016.09.005.
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    • Dai, Ziwei, Alexander A. Shestov, Luhua Lai, and Jason W. Locasale. “A Flux Balance of Glucose Metabolism Clarifies the Requirements of the Warburg Effect.” Biophys J 111, no. 5 (September 6, 2016): 1088–1100. https://doi.org/10.1016/j.bpj.2016.07.028.
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    • Reid, Michael A., Xazmin H. Lowman, Min Pan, Thai Q. Tran, Marc O. Warmoes, Mari B. Ishak Gabra, Ying Yang, Jason W. Locasale, and Mei Kong. “IKKβ promotes metabolic adaptation to glutamine deprivation via phosphorylation and inhibition of PFKFB3.” Genes Dev 30, no. 16 (August 15, 2016): 1837–51. https://doi.org/10.1101/gad.287235.116.
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    • Ser, Zheng, Xia Gao, Christelle Johnson, Mahya Mehrmohamadi, Xiaojing Liu, Siqi Li, and Jason W. Locasale. “Targeting One Carbon Metabolism with an Antimetabolite Disrupts Pyrimidine Homeostasis and Induces Nucleotide Overflow.” Cell Rep 15, no. 11 (June 14, 2016): 2367–76. https://doi.org/10.1016/j.celrep.2016.05.035.
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    • Chiyoda, Tatsuyuki, Xiaojing Liu, Ernst Lengyel, Jason Locasale, and Iris Romero. “Abstract A68: Sphingosine kinase 1 as a mediator and predictor of metformin's protective effect in ovarian cancer.” Other Topics, January 15, 2016. https://doi.org/10.1158/1557-3265.ovca15-a68.
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    • Barker, Brandon E., Narayanan Sadagopan, Yiping Wang, Kieran Smallbone, Christopher R. Myers, Hongwei Xi, Jason W. Locasale, and Zhenglong Gu. “A robust and efficient method for estimating enzyme complex abundance and metabolic flux from expression data.” Comput Biol Chem 59 Pt B (December 2015): 98–112. https://doi.org/10.1016/j.compbiolchem.2015.08.002.
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    • Chen, Jinyu, Ho-Jeong Lee, Xuefeng Wu, Lei Huo, Sun-Jin Kim, Lei Xu, Yan Wang, et al. “Gain of glucose-independent growth upon metastasis of breast cancer cells to the brain.” Cancer Res 75, no. 3 (February 1, 2015): 554–65. https://doi.org/10.1158/0008-5472.CAN-14-2268.
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    • Johnson, Christelle, Marc O. Warmoes, Xiling Shen, and Jason W. Locasale. “Epigenetics and cancer metabolism.” Cancer Lett 356, no. 2 Pt A (January 28, 2015): 309–14. https://doi.org/10.1016/j.canlet.2013.09.043.
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    • Cluntun, Ahmad A., He Huang, Lunzhi Dai, Xiaojing Liu, Yingming Zhao, and Jason W. Locasale. “The rate of glycolysis quantitatively mediates specific histone acetylation sites.” Cancer Metab 3 (2015): 10. https://doi.org/10.1186/s40170-015-0135-3.
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    • Crowe, Kristi M., David Allison, and David Bioactive Food Components Conference Speakers. “Evaluating bioactive food components in obesity and cancer prevention.” Crit Rev Food Sci Nutr 55, no. 5 (2015): 732–34. https://doi.org/10.1080/10408398.2013.878305.
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    • Gerriets, Valerie A., Rigel J. Kishton, Amanda G. Nichols, Andrew N. Macintyre, Makoto Inoue, Olga Ilkayeva, Peter S. Winter, et al. “Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation.” J Clin Invest 125, no. 1 (January 2015): 194–207. https://doi.org/10.1172/JCI76012.
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    • Madhukar, Neel S., Marc O. Warmoes, and Jason W. Locasale. “Organization of enzyme concentration across the metabolic network in cancer cells.” Plos One 10, no. 1 (2015): e0117131. https://doi.org/10.1371/journal.pone.0117131.
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    • Mehrmohamadi, Mahya, Xiaojing Liu, Alexander A. Shestov, and Jason W. Locasale. “Characterization of the usage of the serine metabolic network in human cancer.” Cell Rep 9, no. 4 (November 20, 2014): 1507–19. https://doi.org/10.1016/j.celrep.2014.10.026.
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    • Huang, Lei, Dongsung Kim, Xiaojing Liu, Christopher R. Myers, and Jason W. Locasale. “Estimating relative changes of metabolic fluxes.” Plos Comput Biol 10, no. 11 (November 2014): e1003958. https://doi.org/10.1371/journal.pcbi.1003958.
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    • Liu, T., R. J. Kishton, A. N. Macintyre, V. A. Gerriets, H. Xiang, X. Liu, E. D. Abel, D. Rizzieri, J. W. Locasale, and J. C. Rathmell. “Glucose transporter 1-mediated glucose uptake is limiting for B-cell acute lymphoblastic leukemia anabolic metabolism and resistance to apoptosis.” Cell Death & Disease 5, no. 11 (November 2014): e1516-. https://doi.org/10.1038/cddis.2014.493.
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    • Warmoes, Marc O., and Jason W. Locasale. “Heterogeneity of glycolysis in cancers and therapeutic opportunities.” Biochem Pharmacol 92, no. 1 (November 1, 2014): 12–21. https://doi.org/10.1016/j.bcp.2014.07.019.
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    • Liu, T., R. J. Kishton, A. N. Macintyre, V. A. Gerriets, H. Xiang, X. Liu, E. D. Abel, D. Rizzieri, J. W. Locasale, and J. C. Rathmell. “Glucose transporter 1-mediated glucose uptake is limiting for B-cell acute lymphoblastic leukemia anabolic metabolism and resistance to apoptosis.” Cell Death Dis 5 (October 16, 2014): e1470. https://doi.org/10.1038/cddis.2014.431.
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    • Shestov, Alexander A., Xiaojing Liu, Zheng Ser, Ahmad A. Cluntun, Yin P. Hung, Lei Huang, Dongsung Kim, et al. “Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step.” Elife 3 (July 9, 2014). https://doi.org/10.7554/eLife.03342.
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    • Shestov, Alexander A., Xiaojing Liu, Zheng Ser, Ahmad A. Cluntun, Yin P. Hung, Lei Huang, Dongsung Kim, et al. “Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step.” Elife 3 (July 9, 2014). https://doi.org/10.7554/eLife.03342.
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    • Liu, Xiaojing, Zheng Ser, Ahmad A. Cluntun, Samantha J. Mentch, and Jason W. Locasale. “A strategy for sensitive, large scale quantitative metabolomics.” J Vis Exp, no. 87 (May 27, 2014). https://doi.org/10.3791/51358.
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    • Dasgupta, Tathagata, David H. Croll, Jeremy A. Owen, Matthew G. Vander Heiden, Jason W. Locasale, Uri Alon, Lewis C. Cantley, and Jeremy Gunawardena. “A fundamental trade-off in covalent switching and its circumvention by enzyme bifunctionality in glucose homeostasis.” J Biol Chem 289, no. 19 (May 9, 2014): 13010–25. https://doi.org/10.1074/jbc.M113.546515.
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    • Sun, S., G. Shi, X. Han, A. B. Francisco, Y. Ji, N. Mendonça, X. Liu, et al. “Erratum: Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation, endoplasmic reticulum homeostasis, and survival (Proceedings of the National Academy of Sciences of the United States of America (2014) 111, 5, (E582-E591) doi:10.1073/pnas.1318114111).” Proceedings of the National Academy of Sciences of the United States of America 111, no. 16 (April 22, 2014): 6115. https://doi.org/10.1073/pnas.1405563111.
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    • Liu, Xiaojing, Zheng Ser, and Jason W. Locasale. “Development and quantitative evaluation of a high-resolution metabolomics technology.” Anal Chem 86, no. 4 (February 18, 2014): 2175–84. https://doi.org/10.1021/ac403845u.
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    • Sun, Shengyi, Guojun Shi, Xuemei Han, Adam B. Francisco, Yewei Ji, Nuno Mendonça, Xiaojing Liu, et al. “Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation, endoplasmic reticulum homeostasis, and survival.” Proc Natl Acad Sci U S A 111, no. 5 (February 4, 2014): E582–91. https://doi.org/10.1073/pnas.1318114111.
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    • Chen, Kai-Yuan, Xiaojing Liu, Pengcheng Bu, Chieh-Sheng Lin, Nikolai Rakhilin, Jason W. Locasale, and Xiling Shen. “A metabolic signature of colon cancer initiating cells.” Annu Int Conf Ieee Eng Med Biol Soc 2014 (2014): 4759–62. https://doi.org/10.1109/EMBC.2014.6944688.
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    • Johnson, Christelle, Kai-Yuan Chen, Xiaojing Liu, Pengcheng Bu, Jason Locasale, and Xiling Shen. “A metabolic signature of colon cancer initiating cells.” Cancer & Metabolism 2, no. Suppl 1 (January 2014): P32–P32. https://doi.org/10.1186/2049-3002-2-s1-p32.
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    • Liu, T., R. J. Kishton, A. N. Macintyre, V. A. Gerriets, H. Xiang, X. Liu, E. D. Abel, D. Rizzieri, J. W. Locasale, and J. C. Rathmell. “Glucose transporter 1-mediated glucose uptake is limiting for B-cell acute lymphoblastic leukemia anabolic metabolism and resistance to apoptosis.” Cell Death Dis 5 (2014): e1516. https://doi.org/10.1038/cddis.2014.493.
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    • Parkhitko, Andrey A., Carmen Priolo, Jonathan L. Coloff, Jihye Yun, Julia J. Wu, Kenji Mizumura, Wenping Xu, et al. “Autophagy-dependent metabolic reprogramming sensitizes TSC2-deficient cells to the antimetabolite 6-aminonicotinamide.” Mol Cancer Res 12, no. 1 (January 2014): 48–57. https://doi.org/10.1158/1541-7786.MCR-13-0258-T.
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    • Shestov, Alexander A., Brandon Barker, Zhenglong Gu, and Jason W. Locasale. “Computational approaches for understanding energy metabolism.” Wiley Interdiscip Rev Syst Biol Med 5, no. 6 (November 2013): 733–50. https://doi.org/10.1002/wsbm.1238.
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    • Locasale, Jason W. “Serine, glycine and one-carbon units: cancer metabolism in full circle.” Nat Rev Cancer 13, no. 8 (August 2013): 572–83. https://doi.org/10.1038/nrc3557.
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    • Hu, Jie, Jason W. Locasale, Jason H. Bielas, Jacintha O’Sullivan, Kieran Sheahan, Lewis C. Cantley, Matthew G. Vander Heiden, and Dennis Vitkup. “Heterogeneity of tumor-induced gene expression changes in the human metabolic network.” Nat Biotechnol 31, no. 6 (June 2013): 522–29. https://doi.org/10.1038/nbt.2530.
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    • Shyh-Chang, Ng, Jason W. Locasale, Costas A. Lyssiotis, Yuxiang Zheng, Ren Yi Teo, Sutheera Ratanasirintrawoot, Jin Zhang, et al. “Influence of threonine metabolism on S-adenosylmethionine and histone methylation.” Science 339, no. 6116 (January 11, 2013): 222–26. https://doi.org/10.1126/science.1226603.
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    • Baker, Rachael, Steven M. Lewis, Atsuo T. Sasaki, Emily M. Wilkerson, Jason W. Locasale, Lewis C. Cantley, Brian Kuhlman, Henrik G. Dohlman, and Sharon L. Campbell. “Site-specific monoubiquitination activates Ras by impeding GTPase-activating protein function.” Nat Struct Mol Biol 20, no. 1 (January 2013): 46–52. https://doi.org/10.1038/nsmb.2430.
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    • Locasale, Jason W. “The consequences of enhanced cell-autonomous glucose metabolism.” Trends Endocrinol Metab 23, no. 11 (November 2012): 545–51. https://doi.org/10.1016/j.tem.2012.07.005.
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    • Locasale, Jason W. “Metabolic rewiring drives resistance to targeted cancer therapy.” Mol Syst Biol 8 (July 17, 2012): 597. https://doi.org/10.1038/msb.2012.30.
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    • Locasale, Jason W., Tamar Melman, Susan Song, Xuemei Yang, Kenneth D. Swanson, Lewis C. Cantley, Eric T. Wong, and John M. Asara. “Metabolomics of human cerebrospinal fluid identifies signatures of malignant glioma.” Mol Cell Proteomics 11, no. 6 (June 2012): M111.014688. https://doi.org/10.1074/mcp.M111.014688.
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    • Ying, Haoqiang, Alec C. Kimmelman, Costas A. Lyssiotis, Sujun Hua, Gerald C. Chu, Eliot Fletcher-Sananikone, Jason W. Locasale, et al. “Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism.” Cell 149, no. 3 (April 27, 2012): 656–70. https://doi.org/10.1016/j.cell.2012.01.058.
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    • Lyssiotis, C. A., D. Anastasiou, J. W. Locasale, M. G. Vander Heiden, H. R. Christofk, and L. C. Cantley. “Cellular control mechanisms that regulate pyruvate kinase M2 activity and promote cancer growth.” Biomedical Research 23, no. SPEC. ISSUE (February 23, 2012): 213–17.
    • Locasale, Jason W., and Benjamin J. Zeskind. “Maximizing the efficacy of angiogenesis inhibitors.” J Clin Oncol 30, no. 3 (January 20, 2012): 337–38. https://doi.org/10.1200/JCO.2011.38.5435.
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    • Locasale, Jason W., Alexandra Grassian, Rameen Beroukhim, Matthew Meyerson, Gerhard Wagner, John M. Asara, Joan S. Brugge, Matthew G. Vander Heiden, and Lewis C. Cantley. “Amplification of phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis.” Bmc Proceedings 6, no. Suppl 3 (January 2012): O15–O15. https://doi.org/10.1186/1753-6561-6-s3-o15.
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    • Yun, Jihye, Jared L. Johnson, Christin L. Hanigan, and Jason W. Locasale. “Interactions between epigenetics and metabolism in cancers.” Front Oncol 2 (2012): 163. https://doi.org/10.3389/fonc.2012.00163.
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    • Locasale, Jason W., and Benjamin Zeskind. “IL-6 and ovarian cancer--letter.” Clin Cancer Res 17, no. 24 (December 15, 2011): 7837. https://doi.org/10.1158/1078-0432.CCR-11-2170.
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    • Shyh-Chang, Ng, Yuxiang Zheng, Jason W. Locasale, and Lewis C. Cantley. “Human pluripotent stem cells decouple respiration from energy production.” Embo J 30, no. 24 (December 14, 2011): 4851–52. https://doi.org/10.1038/emboj.2011.436.
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    • Anastasiou, Dimitrios, George Poulogiannis, John M. Asara, Matthew B. Boxer, Jian-kang Jiang, Min Shen, Gary Bellinger, et al. “Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses.” Science 334, no. 6060 (December 2, 2011): 1278–83. https://doi.org/10.1126/science.1211485.
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    • Mullarky, Edouard, Katherine R. Mattaini, Matthew G. Vander Heiden, Lewis C. Cantley, and Jason W. Locasale. “PHGDH amplification and altered glucose metabolism in human melanoma.” Pigment Cell Melanoma Res 24, no. 6 (December 2011): 1112–15. https://doi.org/10.1111/j.1755-148X.2011.00919.x.
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    • Locasale, Jason W., and Lewis C. Cantley. “Genetic selection for enhanced serine metabolism in cancer development.” Cell Cycle 10, no. 22 (November 15, 2011): 3812–13. https://doi.org/10.4161/cc.10.22.18224.
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    • Locasale, Jason W., Tamar Melman, Susan S. Song, Xuemei Yang, Kenneth D. Swanson, Lewis C. Cantley, John M. Asara, and Eric T. Wong. “METABOLOMICS PROFILING OF PATIENT CEREBROSPINAL FLUID IDENTIFIES SIGNATURES OF MALIGNANT GLIOMA.” Neuro Oncology 13 (November 1, 2011): 69–69.
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    • Locasale, Jason W., Tamar Melman, Susan S. Song, Xuemei Yang, Kenneth D. Swanson, Lewis C. Cantley, John M. Asara, et al. “METABOLIC PATHWAYS.” Neuro Oncology 13, no. Suppl 3 (November 2011): iii69–72.
    • Gao, Daming, Hiroyuki Inuzuka, Meng-Kwang Marcus Tan, Hidefumi Fukushima, Jason W. Locasale, Pengda Liu, Lixin Wan, et al. “mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR.” Mol Cell 44, no. 2 (October 21, 2011): 290–303. https://doi.org/10.1016/j.molcel.2011.08.030.
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    • Locasale, Jason W., and Lewis C. Cantley. “Metabolic flux and the regulation of mammalian cell growth.” Cell Metab 14, no. 4 (October 5, 2011): 443–51. https://doi.org/10.1016/j.cmet.2011.07.014.
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    • Yi, Caroline H., Heling Pan, Jan Seebacher, Il-Ho Jang, Sven G. Hyberts, Gregory J. Heffron, Matthew G. Vander Heiden, et al. “Metabolic regulation of protein N-alpha-acetylation by Bcl-xL promotes cell survival.” Cell 146, no. 4 (August 19, 2011): 607–20. https://doi.org/10.1016/j.cell.2011.06.050.
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    • Locasale, Jason W., Alexandra R. Grassian, Tamar Melman, Costas A. Lyssiotis, Katherine R. Mattaini, Adam J. Bass, Gregory Heffron, et al. “Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis.” Nat Genet 43, no. 9 (July 31, 2011): 869–74. https://doi.org/10.1038/ng.890.
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    • CANTLEY LEWIS C, K. A., K. A. VANDER HEIDEN MATTHEW, K. A. LOCASALE JASON, and K. A. SHARFI HADAR. “METHODS AND COMPOSITIONS FOR THE DIAGNOSIS AND TREATMENT OF CELLULAR PROLIFERATIVE DISORDERS,” May 26, 2011.
    • Yang, Xuemei, Jason Locasale, Rami Rahal, Susanne Breitkopf, Matthew VanderHeiden, Dimitrios Spentzos, Chin-Lee Wu, et al. “Abstract LB-255: A mass spectrometry platform to quantitatively profile cancer cell metabolism from cells, tumors, and fixed tissue.” Cellular and Molecular Biology, April 15, 2011. https://doi.org/10.1158/1538-7445.am2011-lb-255.
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    • Sasaki, Atsuo T., Arkaitz Carracedo, Jason W. Locasale, Dimitrios Anastasiou, Koh Takeuchi, Emily Rose Kahoud, Sasson Haviv, John M. Asara, Pier Paolo Pandolfi, and Lewis C. Cantley. “Ubiquitination of K-Ras enhances activation and facilitates binding to select downstream effectors.” Sci Signal 4, no. 163 (March 8, 2011): ra13. https://doi.org/10.1126/scisignal.2001518.
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    • Vander Heiden, M. G., S. Y. Lunt, T. L. Dayton, B. P. Fiske, W. J. Israelsen, K. R. Mattaini, N. I. Vokes, et al. “Metabolic pathway alterations that support cell proliferation.” Cold Spring Harb Symp Quant Biol 76 (2011): 325–34. https://doi.org/10.1101/sqb.2012.76.010900.
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    • Locasale, Jason W., Matthew G. Vander Heiden, and Lewis C. Cantley. “Rewiring of glycolysis in cancer cell metabolism.” Cell Cycle 9, no. 21 (November 1, 2010): 4253. https://doi.org/10.4161/cc.9.21.13925.
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    • Vander Heiden, Matthew G., Jason W. Locasale, Kenneth D. Swanson, Hadar Sharfi, Greg J. Heffron, Daniel Amador-Noguez, Heather R. Christofk, et al. “Evidence for an alternative glycolytic pathway in rapidly proliferating cells.” Science 329, no. 5998 (September 17, 2010): 1492–99. https://doi.org/10.1126/science.1188015.
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    • Yang, X., R. Rahal, J. Locasale, S. Song, L. Cantley, E. Wong, N. Perrimon, M. Vander Heiden, and J. Asara. “A Mass Spectrometry Platform to Quantitatively Profile Cancer Cell Metabolism from Cell Lines to Tissues.” Journal of Biomolecular Techniques : Jbt 21, no. 3 Suppl (September 2010): S39–40.
    • Locasale, Jason W., and Lewis C. Cantley. “Altered metabolism in cancer.” Bmc Biol 8 (June 25, 2010): 88. https://doi.org/10.1186/1741-7007-8-88.
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    • Prisic, Sladjana, Selasi Dankwa, Daniel Schwartz, Michael F. Chou, Jason W. Locasale, Choong-Min Kang, Guy Bemis, George M. Church, Hanno Steen, and Robert N. Husson. “Extensive phosphorylation with overlapping specificity by Mycobacterium tuberculosis serine/threonine protein kinases.” Proc Natl Acad Sci U S A 107, no. 16 (April 20, 2010): 7521–26. https://doi.org/10.1073/pnas.0913482107.
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    • Locasale, Jason W., Lewis C. Cantley, and Matthew G. Vander Heiden. “Cancer's insatiable appetite.” Nat Biotechnol 27, no. 10 (October 2009): 916–17. https://doi.org/10.1038/nbt1009-916.
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    • Locasale, Jason W., and Alejandro Wolf-Yadlin. “Maximum entropy reconstructions of dynamic signaling networks from quantitative proteomics data.” Plos One 4, no. 8 (August 26, 2009): e6522. https://doi.org/10.1371/journal.pone.0006522.
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    • Locasale, Jason W., Andrew A. Napoli, Shengfeng Chen, Helen M. Berman, and Catherine L. Lawson. “Signatures of protein-DNA recognition in free DNA binding sites.” J Mol Biol 386, no. 4 (March 6, 2009): 1054–65. https://doi.org/10.1016/j.jmb.2009.01.007.
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    • Locasale, Jason W. “Signal duration and the time scale dependence of signal integration in biochemical pathways.” Bmc Syst Biol 2 (December 17, 2008): 108. https://doi.org/10.1186/1752-0509-2-108.
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    • Locasale, Jason W. “Three-state kinetic mechanism for scaffold-mediated signal transduction.” Phys Rev E Stat Nonlin Soft Matter Phys 78, no. 5 Pt 1 (November 2008): 051921. https://doi.org/10.1103/PhysRevE.78.051921.
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    • Locasale, Jason W., and Arup K. Chakraborty. “Regulation of signal duration and the statistical dynamics of kinase activation by scaffold proteins.” Plos Comput Biol 4, no. 6 (June 27, 2008): e1000099. https://doi.org/10.1371/journal.pcbi.1000099.
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    • Locasale, Jason W., and Arup K. Chakraborty. “Importance of signal duration and the time scale dependence of signal integration in biochemical networks.” Faseb Journal 22 (April 1, 2008).
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    • Locasale, Jason W. “Allovalency revisited: an analysis of multisite phosphorylation and substrate rebinding.” J Chem Phys 128, no. 11 (March 21, 2008): 115106. https://doi.org/10.1063/1.2841124.
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    • Locasale, Jason W. “Scaffold proteins tune the regulatory properties of protein kinase cascades.” Abstracts of Papers of the American Chemical Society 234 (August 19, 2007).
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    • Locasale, Jason W., Andrey S. Shaw, and Arup K. Chakraborty. “Scaffold proteins confer diverse regulatory properties to protein kinase cascades.” Proc Natl Acad Sci U S A 104, no. 33 (August 14, 2007): 13307–12. https://doi.org/10.1073/pnas.0706311104.
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    • Locasale, Jason W. “Computational investigations into the origins of short-term biochemical memory in T cell activation.” Plos One 2, no. 7 (July 18, 2007): e627. https://doi.org/10.1371/journal.pone.0000627.
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    • Cemerski, Saso, Jayajit Das, Jason Locasale, Phoebe Arnold, Emanuele Giurisato, Mary A. Markiewicz, Daved Fremont, Paul M. Allen, Arup K. Chakraborty, and Andrey S. Shaw. “The stimulatory potency of T cell antigens is influenced by the formation of the immunological synapse.” Immunity 26, no. 3 (March 2007): 345–55. https://doi.org/10.1016/j.immuni.2007.01.013.
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  • Book Sections

    • Anastasiou, D., J. W. Locasale, and M. G. Vander Heiden. “Cancer metabolism.” In Systems Biology of Cancer, 295–308, 2015. https://doi.org/10.1017/9780511979811.020.
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    • Patnaik, A., J. W. Locasale, and L. C. Cantley. “Cancer cell metabolism.” In Insulin-like Growth Factors and Cancer: From Basic Biology to Therapeutics, 245–61, 2012. https://doi.org/10.1007/978-1-4614-0598-6_13.
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  • Conference Papers

    • Kim, Leo J. Y., Esther W. Lim, Jason W. Locasale, Andrew E. Sloan, Christian M. Metallo, and Jeremy N. Rich. “Reprogrammed TCA Cycle Maintains a Stem-Like Epitranscriptome and Therapeutic Persistence in Glioblastoma Stem Cells.” In Journal of Neurosurgery, 132:123–123. AMER ASSOC NEUROLOGICAL SURGEONS, 2020.
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    • Liu, Xiaojing, Daniel E. Cooper, Ahmad A. Cluntun, Marc O. Warmoes, Steven Zhao, Michael A. Reid, Juan Liu, et al. “Abstract 792: Acetate production from glucose and coupling to mitochondrial metabolism in mammals.” In Molecular and Cellular Biology / Genetics. American Association for Cancer Research, 2019. https://doi.org/10.1158/1538-7445.sabcs18-792.
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    • Ma, Hong, Shuo Yu, Xiaojing Liu, Yingao Zhang, Thomas Fakadej, Ziqing Liu, Chaoying Yin, et al. “Lin28a Regulates Pathological Cardiac Hypertrophic Growth through Pck2-mediated Enhancement of Anabolic Synthesis.” In Faseb Journal, Vol. 33. WILEY, 2019.
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    • Ma, Hong, Shuo Yu, Xiaojing Liu, Yingao Zhang, Thomas Fakadej, Ziqing Liu, Chaoying Yin, et al. “Abstract 415: Lin28a Regulates Pathological Cardiac Hypertrophic Growth Through Pck2-mediated Enhancement of Anabolic Synthesis.” In Circulation Research, Vol. 123. Ovid Technologies (Wolters Kluwer Health), 2018. https://doi.org/10.1161/res.123.suppl_1.415.
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    • Hart, Peter C., Tatsuyuki Chiyoda, Marion Curtis, Xiaojing Liu, Chun-Yi Chiang, Stephanie McGregor, Ricardo Lastra, Jason Locasale, Ernst Lengyel, and Iris L. Romero. “Abstract 5474: Activity of the S1P pathway promotes ovarian cancer and serves as a novel metabolic target of metformin.” In Molecular and Cellular Biology / Genetics. American Association for Cancer Research, 2018. https://doi.org/10.1158/1538-7445.am2018-5474.
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    • Lee, Jiyoung, Ali Yesilkanal, Casey Frankenberger, Mohamad Elbaz, Daniel Rabe, Jielin Yan, Felicia Rustandy, et al. “Abstract 5497: Effective combination therapy for breast cancer targeting BACH1 and mitochondrial metabolism.” In Molecular and Cellular Biology / Genetics. American Association for Cancer Research, 2018. https://doi.org/10.1158/1538-7445.am2018-5497.
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    • Liberti, Maria V., Ziwei Dai, Suzanne E. Wardell, Joshua A. Baccile, Xiaojing Liu, Xia Gao, Robert Baldi, et al. “Abstract 5496: A predictive model for selective targeting of the Warburg effect through GAPDH inhibition with a natural product.” In Molecular and Cellular Biology / Genetics. American Association for Cancer Research, 2018. https://doi.org/10.1158/1538-7445.am2018-5496.
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    • Sanderson, Sydney M., Peter Mikhael, Ziwei Dai, and Jason W. Locasale. “Abstract 388: p16/MTAP status as a model for investigating gene-environment interactions in metabolism.” In Molecular and Cellular Biology / Genetics. American Association for Cancer Research, 2018. https://doi.org/10.1158/1538-7445.am2018-388.
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    • Garcia, J. N., J. Bagwell, B. Njaine, J. Norman, D. Levic, S. Wopat, S. Miller, et al. “Sheath Cell Invasion and Trans-differentiation Repair Mechanical Damage Caused by Loss of Caveolae in the Zebrafish Notochord.” In Molecular Biology of the Cell, Vol. 28. AMER SOC CELL BIOLOGY, 2017.
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    • Valcarcel, L., V. Torrano, A. R. Cortazar, X. Liu, J. Urosevic, M. Castillo, G. Morciano, et al. “Transcriptional regulation of prostate cancer metabolism.” In European Journal of Cancer, 61:S171–S171. ELSEVIER SCI LTD, 2016.
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    • O-Sullivan, Insug, Zakaria Sibai, Wenwei Zhang, Jason Locasale, Douglas G. Mashek, and Terry G. Unterman. “Fox01 Promotes Glucose Intolerance in Liver-specific Insulin Receptor Knockout (LIRKO) Mice by Regulating ATGL-dependent Lipo lysis and Fatty Acid Oxidation.” In Diabetes, 65:A67–A67. AMER DIABETES ASSOC, 2016.
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    • Liu, Xiaojing, Ernst Lengyel, Iris Romero, and Jason Locasale. “Metformin acts to disrupt mitochondrial-associated metabolic homeostasis in human cancer.” In Abstracts of Papers of the American Chemical Society, Vol. 250. AMER CHEMICAL SOC, 2015.
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    • Romero, Iris L., Xiaojing Liu, Anirban K. Mitra, Ernst Lengyel, and Jason W. Locasale. “Abstract POSTER-TECH-1123: Advancing metformin as therapeutic for ovarian cancer: metabolomic profiling of mouse ovarian tumors identifies metformin-induced global metabolic changes.” In Technologies That Drive Ovarian Cancer Research. American Association for Cancer Research, 2015. https://doi.org/10.1158/1557-3265.ovcasymp14-poster-tech-1123.
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    • Campbell, Sharon L., Rachael Baker, Steven Lewis, Atsuo Sasaki, Emily M. Wilkerson, Jason Locasale, Lewis C. Cantley, Brian Kuhlman, and Henrik Dohlman. “Ras Activity Regulation by Monoubiquitination.” In Faseb Journal, Vol. 27. FEDERATION AMER SOC EXP BIOL, 2013.
       Link to Item
    • Shestov, Alexander, Anthony Mancuso, Jason W. Locasale, and Jerry D. Glickson. “Human melanoma metabolic network analysis with combined 13C NMR/bioreactor technique: testing the Warburg effect.” In Faseb Journal, Vol. 27. FEDERATION AMER SOC EXP BIOL, 2013.
       Link to Item
    • Locasale, Jason W., Arup K. Chakraborty, and Andrey Shaw. “Scaffold proteins confer diverse regulatory properties to protein kinase cascades.” In Faseb Journal, 21:A264–A264. FEDERATION AMER SOC EXP BIOL, 2007.
       Link to Item
    • Castner, E. W., B. J. Lee, E. G. Diken, H. Shirota, M. DeRitter, P. P. Wiewior, and J. W. Locasale. “Friction, dynamics, and length scales in hydrophilic polymers.” In Abstracts of Papers of the American Chemical Society, 225:U446–U446. AMER CHEMICAL SOC, 2003.
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• Teaching & Mentoring
• 

  Recent Courses

  • PHARM 393: Research Independent Study 2021
  • PHARM 493: Research Independent Study 2021
  • PHARM 494: Research Independent Study 2021
  • PHARM 393: Research Independent Study 2020
  • PHARM 493: Research Independent Study 2020
  • PHARM 494: Research Independent Study 2020
  • PHARM 393: Research Independent Study 2019
  • PHARM 493: Research Independent Study 2019
  • PHARM 494: Research Independent Study 2019

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