Jason Locasale
Associate Professor of Pharmacology and Cancer Biology
Our research interests are in three interconnected areas: 1) Quantitative and computational biology of metabolism. 2) The role of diet and pharmacological therapeutics in shaping metabolic pathways in health and cancer. 3) The interaction of metabolism and epigenetics. Each of these synergistic areas utilizes the metabolomics technologies we develop along with our expertise in computational and molecular biology.
Current Appointments & Affiliations
- Associate Professor of Pharmacology and Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2018
- Member of Duke Molecular Physiology Institute, Duke Molecular Physiology Institute, Duke Molecular Physiology Institute 2013
- Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2015
Contact Information
- Background
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Education, Training, & Certifications
- Ph.D., Massachusetts Institute of Technology 2008
- B.A., Rutgers University New Brunswick 2003
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Previous Appointments & Affiliations
- Assistant Professor of Pharmacology & Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2015 - 2018
- Recognition
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In the News
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SEP 17, 2017 Duke Health News
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- Research
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External Relationships
- 5am ventures
- AACR
- Adjunct Professor North Carolina State U (unpaid)
- American Association for Cancer Research
- American Cancer Society
- Aquilo Capital Management
- Bridge Bio
- Cancer and Metabolism Editorial Board
- Cell Stress - editorial board
- Clarion Healthcare
- College of reviewers , canadian institutes of health
- Cornerstone Pharmaceuticals
- Danube Epigenetics Webinair Series - FEBS
- Digatalis Ventures
- Enara bio
- Faeth Therapeutics
- Forbeck Foundation
- Francis Crick Institute - London UK speaker
- Fudan University
- Geistlich Pharmaceuticals
- Harvard Medical School
- Institute for Stem Cell Science & Regenerative Medicine (inStem), Bangalore, India
- International Society for Cancer Metabolism
- Israel Science Foundation
- Keystone Symposia
- Kika, Children Cancer-free Foundation - Netherlands
- Life Metabolism
- NIH
- Nanocare Technologies
- Nestle Health Sciences
- Northwestern University
- Oncotarget - editorial board
- Petri Biologicals
- Plos biology - editorial board
- Raphael Pharmaceuticals
- Restoration Foodworks
- Society for Neurooncology
- Southern University of Science and Technology (SUSTech)
- Swiss Federal Institute of Technology Lausanne
- Tsinghua University
- UC Irvine
- United Health Group Research and Developement
- University of Copenhagen
- University of Helsinki
- University of Iceland
- University of Lausanne
- University of Sydney
- University of Toronto
- Viatris
- Wells Fargo & Co
- Xian Jiaotong University
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Dai, Ziwei, Weiyan Zheng, and Jason W. Locasale. “Amino acid variability, tradeoffs and optimality in human diet.” Nat Commun 13, no. 1 (November 5, 2022): 6683. https://doi.org/10.1038/s41467-022-34486-0.Full Text Link to Item
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Locasale, Jason W. “Diet and Exercise in Cancer Metabolism.” Cancer Discov 12, no. 10 (October 5, 2022): 2249–57. https://doi.org/10.1158/2159-8290.CD-22-0096.Full Text Link to Item
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Gu, Xin, Patrick Jouandin, Pranav V. Lalgudi, Rich Binari, Max L. Valenstein, Michael A. Reid, Annamarie E. Allen, et al. “Author Correction: Sestrin mediates detection of and adaptation to low-leucine diets in Drosophila.” Nature 609, no. 7929 (September 2022): E11. https://doi.org/10.1038/s41586-022-05286-9.Full Text Link to Item
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Karampelias, Christos, Kathleen Watt, Charlotte L. Mattsson, Ángel Fernández Ruiz, Habib Rezanejad, Jiarui Mi, Xiaojing Liu, et al. “MNK2 deficiency potentiates β-cell regeneration via translational regulation.” Nat Chem Biol 18, no. 9 (September 2022): 942–53. https://doi.org/10.1038/s41589-022-01047-x.Full Text Link to Item
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Gu, Xin, Patrick Jouandin, Pranav V. Lalgudi, Rich Binari, Max L. Valenstein, Michael A. Reid, Annamarie E. Allen, et al. “Sestrin mediates detection of and adaptation to low-leucine diets in Drosophila.” Nature 608, no. 7921 (August 2022): 209–16. https://doi.org/10.1038/s41586-022-04960-2.Full Text Link to Item
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Liao, Chengheng, Cherise Ryan Glodowski, Cheng Fan, Juan Liu, Kevin R. Mott, Akash Kaushik, Hieu Vu, et al. “Integrated Metabolic Profiling and Transcriptional Analysis Reveals Therapeutic Modalities for Targeting Rapidly Proliferating Breast Cancers.” Cancer Res 82, no. 4 (February 15, 2022): 665–80. https://doi.org/10.1158/0008-5472.CAN-21-2745.Full Text Link to Item
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Sun, Yudong, and Jason W. Locasale. “Rethinking the bioavailability and cellular transport properties of S-adenosylmethionine.” Cell Stress 6, no. 1 (January 2022): 1–5. https://doi.org/10.15698/cst2022.01.261.Full Text Link to Item
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Cable, Jennifer, Olivier Pourquié, Kathryn E. Wellen, Lydia W. S. Finley, Alexander Aulehla, Alex P. Gould, Aurelio Teleman, et al. “Metabolic decisions in development and disease-a Keystone Symposia report.” Ann N Y Acad Sci 1506, no. 1 (December 2021): 55–73. https://doi.org/10.1111/nyas.14678.Full Text Link to Item
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Nam, Hyeyoung, Anirban Kundu, Suman Karki, Garrett J. Brinkley, Darshan S. Chandrashekar, Richard L. Kirkman, Juan Liu, et al. “The TGF-β/HDAC7 axis suppresses TCA cycle metabolism in renal cancer.” Jci Insight 6, no. 22 (November 22, 2021). https://doi.org/10.1172/jci.insight.148438.Full Text Link to Item
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Di Conza, Giusy, Chin-Hsien Tsai, Hector Gallart-Ayala, Yi-Ru Yu, Fabien Franco, Lea Zaffalon, Xin Xie, et al. “Tumor-induced reshuffling of lipid composition on the endoplasmic reticulum membrane sustains macrophage survival and pro-tumorigenic activity.” Nat Immunol 22, no. 11 (November 2021): 1403–15. https://doi.org/10.1038/s41590-021-01047-4.Full Text Link to Item
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Li, Qinfeng, Chao Li, Abdallah Elnwasany, Gaurav Sharma, Yu A. An, Guangyu Zhang, Waleed M. Elhelaly, et al. “PKM1 Exerts Critical Roles in Cardiac Remodeling Under Pressure Overload in the Heart.” Circulation 144, no. 9 (August 31, 2021): 712–27. https://doi.org/10.1161/CIRCULATIONAHA.121.054885.Full Text Link to Item
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Xiao, Zhengtao, and Jason W. Locasale. “Epigenomic links from metabolism-methionine and chromatin architecture.” Curr Opin Chem Biol 63 (August 2021): 11–18. https://doi.org/10.1016/j.cbpa.2021.01.011.Full Text Link to Item
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Schmidt, Daniel R., Rutulkumar Patel, David G. Kirsch, Caroline A. Lewis, Matthew G. Vander Heiden, and Jason W. Locasale. “Metabolomics in cancer research and emerging applications in clinical oncology.” Ca Cancer J Clin 71, no. 4 (July 2021): 333–58. https://doi.org/10.3322/caac.21670.Full Text Link to Item
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Xu, Lingfan, Yu Yin, Yanjing Li, Xufeng Chen, Yan Chang, Hong Zhang, Juan Liu, et al. “A glutaminase isoform switch drives therapeutic resistance and disease progression of prostate cancer.” Proc Natl Acad Sci U S A 118, no. 13 (March 30, 2021). https://doi.org/10.1073/pnas.2012748118.Full Text Link to Item
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Mason, Joshua A., Jordan A. Cockfield, Daniel J. Pape, Hannah Meissner, Michael T. Sokolowski, Taylor C. White, José C. Valentín López, et al. “SGK1 signaling promotes glucose metabolism and survival in extracellular matrix detached cells.” Cell Rep 34, no. 11 (March 16, 2021): 108821. https://doi.org/10.1016/j.celrep.2021.108821.Full Text Link to Item
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Healey, Diana C Contreras, Jacqueline Y. Cephus, Sierra M. Barone, Nowrin U. Chowdhury, Debolanle O. Dahunsi, Matthew Z. Madden, Xiang Ye, et al. “Targeting In Vivo Metabolic Vulnerabilities of Th2 and Th17 Cells Reduces Airway Inflammation.” J Immunol 206, no. 6 (March 15, 2021): 1127–39. https://doi.org/10.4049/jimmunol.2001029.Full Text Link to Item
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Gu, Chunfang, Juan Liu, Xiaojing Liu, Haibo Zhang, Ji Luo, Huanchen Wang, Jason W. Locasale, and Stephen B. Shears. “Metabolic supervision by PPIP5K, an inositol pyrophosphate kinase/phosphatase, controls proliferation of the HCT116 tumor cell line.” Proc Natl Acad Sci U S A 118, no. 10 (March 9, 2021). https://doi.org/10.1073/pnas.2020187118.Full Text Link to Item
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Allen, Annamarie E., and Jason W. Locasale. “Metabolomics: insights into plant-based diets.” Embo Mol Med 13, no. 2 (February 5, 2021): e13568. https://doi.org/10.15252/emmm.202013568.Full Text Link to Item
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Hwang, Inah, Hiroki Uchida, Ziwei Dai, Fei Li, Teresa Sanchez, Jason W. Locasale, Lewis C. Cantley, Hongwu Zheng, and Jihye Paik. “Cellular stress signaling activates type-I IFN response through FOXO3-regulated lamin posttranslational modification.” Nat Commun 12, no. 1 (January 28, 2021): 640. https://doi.org/10.1038/s41467-020-20839-0.Full Text Link to Item
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Pan, Christopher, and Jason W. Locasale. “Targeting metabolism to influence aging.” Science 371, no. 6526 (January 15, 2021): 234–35. https://doi.org/10.1126/science.abf6368.Full Text Link to Item
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Dai, Ziwei, and Jason Locasale. “Amino acid variability, tradeoffs and optimality in human diet,” 2021. https://doi.org/10.1101/2021.06.16.448627.Full Text
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Duan, Likun, Daniel Cooper, Grace Scheidemantle, Jason Locasale, David Kirsch, and Xiaojing Liu. “13C tracer analysis identifies extensive recycling of endogenous CO2 in vivo,” 2021. https://doi.org/10.1101/2021.02.04.429777.Full Text
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Liao, Chengheng, Cherise Ryan Glodowski, Cheng Fan, Juan Liu, Kevin Raynard Mott, Akash Kaushik, Hieu Vu, et al. “Integrated Metabolic and Gene Expression Profiling Reveals New Therapeutic Modalities for Rapidly Proliferating Breast Cancers,” 2021. https://doi.org/10.21203/rs.3.rs-117384/v2.Full Text
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Meyers, Allison, Zhan Wang, Wenzheng Han, Qingxia Zhao, Manal Zabalawi, Likun Duan, Juan Liu, et al. “Pyruvate dehydrogenase kinase supports macrophage NLRP3 inflammasome activation during acute inflammation,” 2021. https://doi.org/10.1101/2021.10.02.462869.Full Text
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Nam, Hyeyoung, Anirban Kundu, Suman Karki, Garrett Brinkley, Darshan Chandrashekar, Richard Kirkman, Juan Liu, et al. “TGF-β signaling suppresses TCA cycle metabolism in renal cancer,” 2021. https://doi.org/10.1101/2021.02.19.429599.Full Text
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Quek, Lake-Ee, James R. Krycer, Satoshi Ohno, Katsuyuki Yugi, Daniel J. Fazakerley, Richard Scalzo, Sarah D. Elkington, et al. “Erratum: Dynamic 13C Flux Analysis Captures the Reorganization of Adipocyte Glucose Metabolism in Response to Insulin.” Iscience 23, no. 12 (December 18, 2020): 101786. https://doi.org/10.1016/j.isci.2020.101786.Full Text Link to Item
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Liao, Chengheng, Cherise Ryan Glodowski, Cheng Fan, Juan Liu, Kevin Raynard Mott, Jason Locasale, Samuel McBrayer, Ralph DeBerardinis, Charles Perou, and Qing Zhang. “Integrated Metabolic Profiling and Gene Expression Analysis Reveals Therapeutic Modalities in Breast Cancer,” December 9, 2020. https://doi.org/10.21203/rs.3.rs-117384/v1.Full Text
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Dai, Ziwei, Vijyendra Ramesh, and Jason W. Locasale. “Author Correction: The evolving metabolic landscape of chromatin biology and epigenetics.” Nat Rev Genet 21, no. 12 (December 2020): 782. https://doi.org/10.1038/s41576-020-00291-y.Full Text Link to Item
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Dai, Ziwei, Vijyendra Ramesh, and Jason W. Locasale. “The evolving metabolic landscape of chromatin biology and epigenetics.” Nat Rev Genet 21, no. 12 (December 2020): 737–53. https://doi.org/10.1038/s41576-020-0270-8.Full Text Link to Item
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Yu, Yi-Ru, Hana Imrichova, Haiping Wang, Tung Chao, Zhengtao Xiao, Min Gao, Marcela Rincon-Restrepo, et al. “Disturbed mitochondrial dynamics in CD8+ TILs reinforce T cell exhaustion.” Nat Immunol 21, no. 12 (December 2020): 1540–51. https://doi.org/10.1038/s41590-020-0793-3.Full Text Link to Item
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Brinkley, Garrett, Hyeyoung Nam, Eunhee Shim, Richard Kirkman, Anirban Kundu, Suman Karki, Yasaman Heidarian, et al. “Teleological role of L-2-hydroxyglutarate dehydrogenase in the kidney.” Dis Model Mech 13, no. 11 (November 27, 2020). https://doi.org/10.1242/dmm.045898.Full Text Link to Item
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Gut, Philipp, Sanna Matilainen, Jesse G. Meyer, Pieti Pällijeff, Joy Richard, Christopher J. Carroll, Liliya Euro, et al. “SUCLA2 mutations cause global protein succinylation contributing to the pathomechanism of a hereditary mitochondrial disease.” Nat Commun 11, no. 1 (November 23, 2020): 5927. https://doi.org/10.1038/s41467-020-19743-4.Full Text Link to Item
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Bose, Shree, Annamarie E. Allen, and Jason W. Locasale. “The Molecular Link from Diet to Cancer Cell Metabolism.” Mol Cell 80, no. 3 (November 5, 2020): 554. https://doi.org/10.1016/j.molcel.2020.10.006.Full Text Link to Item
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Liao, Chengheng, Yang Zhang, Cheng Fan, Laura E. Herring, Juan Liu, Jason W. Locasale, Mamoru Takada, et al. “Identification of BBOX1 as a Therapeutic Target in Triple-Negative Breast Cancer.” Cancer Discov 10, no. 11 (November 2020): 1706–21. https://doi.org/10.1158/2159-8290.CD-20-0288.Full Text Link to Item
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Liu, Shiyu, Ziwei Dai, Daniel E. Cooper, David G. Kirsch, and Jason W. Locasale. “Quantitative Analysis of the Physiological Contributions of Glucose to the TCA Cycle.” Cell Metab 32, no. 4 (October 6, 2020): 619-628.e21. https://doi.org/10.1016/j.cmet.2020.09.005.Full Text Link to Item
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Dai, Ziwei, and Jason W. Locasale. “Cooperative virus propagation in COVID-19 transmission.” Medrxiv, September 18, 2020. https://doi.org/10.1101/2020.05.05.20092361.Full Text Link to Item
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Hoxhaj, Gerta, Jason W. Locasale, and Issam Ben-Sahra. “A spoonful of DHAP keeps mTORC1 running on sugars.” Nat Metab 2, no. 9 (September 2020): 801–2. https://doi.org/10.1038/s42255-020-0246-1.Full Text Link to Item
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Deblois, Geneviève, Seyed Ali Madani Tonekaboni, Giacomo Grillo, Constanza Martinez, Yunchi Ingrid Kao, Felicia Tai, Ilias Ettayebi, et al. “Epigenetic Switch-Induced Viral Mimicry Evasion in Chemotherapy-Resistant Breast Cancer.” Cancer Discov 10, no. 9 (September 2020): 1312–29. https://doi.org/10.1158/2159-8290.CD-19-1493.Full Text Link to Item
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Xu, Qing, Yuanyuan Li, Xia Gao, Kai Kang, Jason G. Williams, Lingfeng Tong, Juan Liu, et al. “HNF4α regulates sulfur amino acid metabolism and confers sensitivity to methionine restriction in liver cancer.” Nat Commun 11, no. 1 (August 7, 2020): 3978. https://doi.org/10.1038/s41467-020-17818-w.Full Text Link to Item
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Bose, Shree, Annamarie E. Allen, and Jason W. Locasale. “The Molecular Link from Diet to Cancer Cell Metabolism.” Mol Cell 78, no. 6 (June 18, 2020): 1034–44. https://doi.org/10.1016/j.molcel.2020.05.018.Full Text Link to Item
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Britt, Emily C., Steven V. John, Jason W. Locasale, and Jing Fan. “Metabolic regulation of epigenetic remodeling in immune cells.” Curr Opin Biotechnol 63 (June 2020): 111–17. https://doi.org/10.1016/j.copbio.2019.12.008.Full Text Link to Item
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Ke, Wenfan, James A. Saba, Cong-Hui Yao, Michael A. Hilzendeger, Anna Drangowska-Way, Chintan Joshi, Vinod K. Mony, et al. “Dietary serine-microbiota interaction enhances chemotherapeutic toxicity without altering drug conversion.” Nat Commun 11, no. 1 (May 22, 2020): 2587. https://doi.org/10.1038/s41467-020-16220-w.Full Text Link to Item
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Ramesh, Vijyendra, and Jason W. Locasale. “A reactive metabolite as an immune suppressant.” Nat Immunol 21, no. 5 (May 2020): 497–98. https://doi.org/10.1038/s41590-020-0664-y.Full Text Link to Item
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Fox, Douglas B., Nina Marie G. Garcia, Brock J. McKinney, Ryan Lupo, Laura C. Noteware, Rachel Newcomb, Juan Liu, Jason W. Locasale, Matthew D. Hirschey, and James V. Alvarez. “NRF2 activation promotes the recurrence of dormant tumour cells through regulation of redox and nucleotide metabolism.” Nat Metab 2, no. 4 (April 2020): 318–34. https://doi.org/10.1038/s42255-020-0191-z.Full Text Link to Item
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Lin, Kevin H., Justine C. Rutter, Abigail Xie, Bryann Pardieu, Emily T. Winn, Reinaldo Dal Bello, Antoine Forget, et al. “Using antagonistic pleiotropy to design a chemotherapy-induced evolutionary trap to target drug resistance in cancer.” Nat Genet 52, no. 4 (April 2020): 408–17. https://doi.org/10.1038/s41588-020-0590-9.Full Text Link to Item
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Shats, Igor, Jason G. Williams, Juan Liu, Mikhail V. Makarov, Xiaoyue Wu, Fred B. Lih, Leesa J. Deterding, et al. “Bacteria Boost Mammalian Host NAD Metabolism by Engaging the Deamidated Biosynthesis Pathway.” Cell Metab 31, no. 3 (March 3, 2020): 564-579.e7. https://doi.org/10.1016/j.cmet.2020.02.001.Full Text Link to Item
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Liberti, Maria V., and Jason W. Locasale. “Histone Lactylation: A New Role for Glucose Metabolism.” Trends Biochem Sci 45, no. 3 (March 2020): 179–82. https://doi.org/10.1016/j.tibs.2019.12.004.Full Text Link to Item
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Davis, Ryan T., Kerrigan Blake, Dennis Ma, Mari B Ishak Gabra, Grace A. Hernandez, Anh T. Phung, Ying Yang, et al. “Transcriptional diversity and bioenergetic shift in human breast cancer metastasis revealed by single-cell RNA sequencing.” Nat Cell Biol 22, no. 3 (March 2020): 310–20. https://doi.org/10.1038/s41556-020-0477-0.Full Text Link to Item
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Quek, Lake-Ee, James R. Krycer, Satoshi Ohno, Katsuyuki Yugi, Daniel J. Fazakerley, Richard Scalzo, Sarah D. Elkington, et al. “Dynamic 13C Flux Analysis Captures the Reorganization of Adipocyte Glucose Metabolism in Response to Insulin.” Iscience 23, no. 2 (February 21, 2020): 100855. https://doi.org/10.1016/j.isci.2020.100855.Full Text Link to Item
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Rumala, Courtney Zasha, Juan Liu, Jason Wei Locasale, Barbara Ellen Corkey, Jude Thaddeus Deeney, and Lucia Egydio Rameh. “Exposure of Pancreatic β-Cells to Excess Glucose Results in Bimodal Activation of mTORC1 and mTOR-Dependent Metabolic Acceleration.” Iscience 23, no. 2 (February 21, 2020): 100858. https://doi.org/10.1016/j.isci.2020.100858.Full Text Link to Item
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Tang, Shuang, Xiaoling Li, and Jason W. Locasale. “Dietary Methionine in T Cell Biology and Autoimmune Disease.” Cell Metab 31, no. 2 (February 4, 2020): 211–12. https://doi.org/10.1016/j.cmet.2020.01.007.Full Text Link to Item
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Liberti, Maria V., Annamarie E. Allen, Vijyendra Ramesh, Ziwei Dai, Katherine R. Singleton, Zufeng Guo, Jun O. Liu, Kris C. Wood, and Jason W. Locasale. “Evolved resistance to partial GAPDH inhibition results in loss of the Warburg effect and in a different state of glycolysis.” J Biol Chem 295, no. 1 (January 3, 2020): 111–24. https://doi.org/10.1074/jbc.RA119.010903.Full Text Link to Item
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Sanderson, Sydney, Zhengtao Xiao, Amy Wisdom, Shree Bose, Maria Liberti, Michael Reid, Emily Hocke, Simon Gregory, David Kirsch, and Jason Locasale. “The Na+/K+ATPase Regulates Glycolysis and Modifies Immune Metabolism in Tumors,” 2020. https://doi.org/10.1101/2020.03.31.018739.Full Text
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Xiao, Zhengtao, Jason W. Locasale, and Ziwei Dai. “Metabolism in the tumor microenvironment: insights from single-cell analysis.” Oncoimmunology 9, no. 1 (2020): 1726556. https://doi.org/10.1080/2162402X.2020.1726556.Full Text Link to Item
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Guo, Zufeng, Zhiqiang Cheng, Jingxin Wang, Wukun Liu, Hanjing Peng, Yuefan Wang, AV Subba Rao, et al. “Discovery of a Potent GLUT Inhibitor from a Library of Rapafucins by Using 3D Microarrays.” Angew Chem Int Ed Engl 58, no. 48 (November 25, 2019): 17158–62. https://doi.org/10.1002/anie.201905578.Full Text Link to Item
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Tabilas, Cybelle, Jocelyn Wang, Xiaojing Liu, Jason W. Locasale, Norah L. Smith, and Brian D. Rudd. “Cutting Edge: Elevated Glycolytic Metabolism Limits the Formation of Memory CD8+ T Cells in Early Life.” J Immunol 203, no. 10 (November 15, 2019): 2571–76. https://doi.org/10.4049/jimmunol.1900426.Full Text Link to Item
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Zurlo, Giada, Xijuan Liu, Mamoru Takada, Cheng Fan, Jeremy M. Simon, Travis S. Ptacek, Javier Rodriguez, et al. “Prolyl hydroxylase substrate adenylosuccinate lyase is an oncogenic driver in triple negative breast cancer.” Nat Commun 10, no. 1 (November 15, 2019): 5177. https://doi.org/10.1038/s41467-019-13168-4.Full Text Link to Item
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Liu, Shiyu, Ziwei Dai, Daniel Cooper, David Kirsch, and Jason Locasale. “Quantitative analysis of the physiological contributions of glucose to the TCA cycle,” November 13, 2019. https://doi.org/10.1101/840538.Full Text
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Langston, P Kent, Aya Nambu, Jonathan Jung, Munehiko Shibata, H Ibrahim Aksoylar, Jiahui Lei, Peining Xu, et al. “Author Correction: Glycerol phosphate shuttle enzyme GPD2 regulates macrophage inflammatory responses.” Nat Immunol 20, no. 11 (November 2019): 1555. https://doi.org/10.1038/s41590-019-0517-8.Full Text Link to Item
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Sanderson, Sydney M., Xia Gao, Ziwei Dai, and Jason W. Locasale. “Methionine metabolism in health and cancer: a nexus of diet and precision medicine.” Nat Rev Cancer 19, no. 11 (November 2019): 625–37. https://doi.org/10.1038/s41568-019-0187-8.Full Text Link to Item
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Bose, Shree, Vijyendra Ramesh, and Jason W. Locasale. “Acetate Metabolism in Physiology, Cancer, and Beyond.” Trends Cell Biol 29, no. 9 (September 2019): 695–703. https://doi.org/10.1016/j.tcb.2019.05.005.Full Text Link to Item
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Langston, P Kent, Aya Nambu, Jonathan Jung, Munehiko Shibata, H Ibrahim Aksoylar, Jiahui Lei, Peining Xu, et al. “Glycerol phosphate shuttle enzyme GPD2 regulates macrophage inflammatory responses.” Nat Immunol 20, no. 9 (September 2019): 1186–95. https://doi.org/10.1038/s41590-019-0453-7.Full Text Link to Item
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Xiao, Zhengtao, Ziwei Dai, and Jason W. Locasale. “Metabolic landscape of the tumor microenvironment at single cell resolution.” Nat Commun 10, no. 1 (August 21, 2019): 3763. https://doi.org/10.1038/s41467-019-11738-0.Full Text Link to Item
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Gao, Xia, Sydney M. Sanderson, Ziwei Dai, Michael A. Reid, Daniel E. Cooper, Min Lu, John P. Richie, et al. “Dietary methionine influences therapy in mouse cancer models and alters human metabolism.” Nature 572, no. 7769 (August 2019): 397–401. https://doi.org/10.1038/s41586-019-1437-3.Full Text Link to Item
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Park, Sunghee, Rachid Safi, Xiaojing Liu, Robert Baldi, Wen Liu, Juan Liu, Jason W. Locasale, Ching-Yi Chang, and Donald P. McDonnell. “Inhibition of ERRα Prevents Mitochondrial Pyruvate Uptake Exposing NADPH-Generating Pathways as Targetable Vulnerabilities in Breast Cancer.” Cell Rep 27, no. 12 (June 18, 2019): 3587-3601.e4. https://doi.org/10.1016/j.celrep.2019.05.066.Full Text Link to Item
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Sanderson, Sydney M., Peter G. Mikhael, Vijyendra Ramesh, Ziwei Dai, and Jason W. Locasale. “Nutrient availability shapes methionine metabolism in p16/MTAP-deleted cells.” Sci Adv 5, no. 6 (June 2019): eaav7769. https://doi.org/10.1126/sciadv.aav7769.Full Text Link to Item
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Ma, Hong, Shuo Yu, Xiaojing Liu, Yingao Zhang, Thomas Fakadej, Ziqing Liu, Chaoying Yin, et al. “Lin28a Regulates Pathological Cardiac Hypertrophic Growth Through Pck2-Mediated Enhancement of Anabolic Synthesis.” Circulation 139, no. 14 (April 2, 2019): 1725–40. https://doi.org/10.1161/CIRCULATIONAHA.118.037803.Full Text Link to Item
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Lee, Jiyoung, Ali E. Yesilkanal, Joseph P. Wynne, Casey Frankenberger, Juan Liu, Jielin Yan, Mohamad Elbaz, et al. “Effective breast cancer combination therapy targeting BACH1 and mitochondrial metabolism.” Nature 568, no. 7751 (April 2019): 254–58. https://doi.org/10.1038/s41586-019-1005-x.Full Text Link to Item
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Hart, Peter C., Tatsuyuki Chiyoda, Xiaojing Liu, Melanie Weigert, Marion Curtis, Chun-Yi Chiang, Rachel Loth, et al. “SPHK1 Is a Novel Target of Metformin in Ovarian Cancer.” Mol Cancer Res 17, no. 4 (April 2019): 870–81. https://doi.org/10.1158/1541-7786.MCR-18-0409.Full Text Link to Item
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Vodnala, Suman Kumar, Robert Eil, Rigel J. Kishton, Madhusudhanan Sukumar, Tori N. Yamamoto, Ngoc-Han Ha, Ping-Hsien Lee, et al. “T cell stemness and dysfunction in tumors are triggered by a common mechanism.” Science 363, no. 6434 (March 29, 2019). https://doi.org/10.1126/science.aau0135.Full Text Link to Item
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Sinclair, Linda V., Andrew Jm Howden, Alejandro Brenes, Laura Spinelli, Jens L. Hukelmann, Andrew N. Macintyre, Xiaojing Liu, et al. “Antigen receptor control of methionine metabolism in T cells.” Elife 8 (March 27, 2019). https://doi.org/10.7554/eLife.44210.Full Text Link to Item
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Gao, Xia, Jason W. Locasale, and Michael A. Reid. “Serine and Methionine Metabolism: Vulnerabilities in Lethal Prostate Cancer.” Cancer Cell 35, no. 3 (March 18, 2019): 339–41. https://doi.org/10.1016/j.ccell.2019.02.014.Full Text Link to Item
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Yang, Ying, Mari B. Ishak Gabra, Eric A. Hanse, Xazmin H. Lowman, Thai Q. Tran, Haiqing Li, Neta Milman, et al. “MiR-135 suppresses glycolysis and promotes pancreatic cancer cell adaptation to metabolic stress by targeting phosphofructokinase-1.” Nat Commun 10, no. 1 (February 18, 2019): 809. https://doi.org/10.1038/s41467-019-08759-0.Full Text Link to Item
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Freemerman, Alex J., Liyang Zhao, Ajeeth K. Pingili, Bin Teng, Alyssa J. Cozzo, Ashley M. Fuller, Amy R. Johnson, et al. “Myeloid Slc2a1-Deficient Murine Model Revealed Macrophage Activation and Metabolic Phenotype Are Fueled by GLUT1.” J Immunol 202, no. 4 (February 15, 2019): 1265–86. https://doi.org/10.4049/jimmunol.1800002.Full Text Link to Item
-
Cao, Jennifer Yinuo, Aunoy Poddar, Leslie Magtanong, Jennifer H. Lumb, Trevor R. Mileur, Michael A. Reid, Cole M. Dovey, et al. “A Genome-wide Haploid Genetic Screen Identifies Regulators of Glutathione Abundance and Ferroptosis Sensitivity.” Cell Rep 26, no. 6 (February 5, 2019): 1544-1556.e8. https://doi.org/10.1016/j.celrep.2019.01.043.Full Text Link to Item
-
Gemta, Lelisa F., Peter J. Siska, Marin E. Nelson, Xia Gao, Xiaojing Liu, Jason W. Locasale, Hideo Yagita, et al. “Impaired enolase 1 glycolytic activity restrains effector functions of tumor-infiltrating CD8+ T cells.” Sci Immunol 4, no. 31 (January 25, 2019). https://doi.org/10.1126/sciimmunol.aap9520.Full Text Link to Item
-
Daniels, Brian P., Sigal B. Kofman, Julian R. Smith, Geoffrey T. Norris, Annelise G. Snyder, Joseph P. Kolb, Xia Gao, et al. “The Nucleotide Sensor ZBP1 and Kinase RIPK3 Induce the Enzyme IRG1 to Promote an Antiviral Metabolic State in Neurons.” Immunity 50, no. 1 (January 15, 2019): 64-76.e4. https://doi.org/10.1016/j.immuni.2018.11.017.Full Text Link to Item
-
Curtis, Marion, Hilary A. Kenny, Bradley Ashcroft, Abir Mukherjee, Alyssa Johnson, Yilin Zhang, Ynes Helou, et al. “Fibroblasts Mobilize Tumor Cell Glycogen to Promote Proliferation and Metastasis.” Cell Metab 29, no. 1 (January 8, 2019): 141-155.e9. https://doi.org/10.1016/j.cmet.2018.08.007.Full Text Link to Item
-
May, Jasmine L., Fotini M. Kouri, Lisa A. Hurley, Juan Liu, Serena Tommasini-Ghelfi, Yanrong Ji, Peng Gao, et al. “IDH3α regulates one-carbon metabolism in glioblastoma.” Sci Adv 5, no. 1 (January 2019): eaat0456. https://doi.org/10.1126/sciadv.aat0456.Full Text Link to Item
-
Reid, Michael A., Annamarie E. Allen, Shiyu Liu, Maria V. Liberti, Pei Liu, Xiaojing Liu, Ziwei Dai, et al. “Serine synthesis through PHGDH coordinates nucleotide levels by maintaining central carbon metabolism.” Nat Commun 9, no. 1 (December 21, 2018): 5442. https://doi.org/10.1038/s41467-018-07868-6.Full Text Link to Item
-
Dai, Ziwei, and Jason W. Locasale. “Thermodynamic constraints on the regulation of metabolic fluxes.” J Biol Chem 293, no. 51 (December 21, 2018): 19725–39. https://doi.org/10.1074/jbc.RA118.004372.Full Text Link to Item
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Johnson, Marc O., Melissa M. Wolf, Matthew Z. Madden, Gabriela Andrejeva, Ayaka Sugiura, Diana C. Contreras, Damian Maseda, et al. “Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism.” Cell 175, no. 7 (December 13, 2018): 1780-1795.e19. https://doi.org/10.1016/j.cell.2018.10.001.Full Text Link to Item
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Sanderson, Sydney M., and Jason W. Locasale. “Revisiting the Warburg Effect: Some Tumors Hold Their Breath.” Cell Metab 28, no. 5 (November 6, 2018): 669–70. https://doi.org/10.1016/j.cmet.2018.10.011.Full Text Link to Item
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Stone, Oliver A., Mohamed El-Brolosy, Kerstin Wilhelm, Xiaojing Liu, Ana M. Romão, Elisabetta Grillo, Jason K. H. Lai, et al. “Loss of pyruvate kinase M2 limits growth and triggers innate immune signaling in endothelial cells.” Nat Commun 9, no. 1 (October 9, 2018): 4077. https://doi.org/10.1038/s41467-018-06406-8.Full Text Link to Item
-
Liu, Xiaojing, Daniel E. Cooper, Ahmad A. Cluntun, Marc O. Warmoes, Steven Zhao, Michael A. Reid, Juan Liu, et al. “Acetate Production from Glucose and Coupling to Mitochondrial Metabolism in Mammals.” Cell 175, no. 2 (October 4, 2018): 502-513.e13. https://doi.org/10.1016/j.cell.2018.08.040.Full Text Link to Item
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Bechard, Matthew E., Anna E. Word, Amanda V. Tran, Xiaojing Liu, Jason W. Locasale, and Oliver G. McDonald. “Pentose conversions support the tumorigenesis of pancreatic cancer distant metastases.” Oncogene 37, no. 38 (September 2018): 5248–56. https://doi.org/10.1038/s41388-018-0346-5.Full Text Link to Item
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Gamble, L. J., C. W. Frye, C. M. Hansen, J. W. Locasale, X. Liu, M. S. Davis, and J. J. Wakshlag. “Serum metabolomics of Alaskan sled dogs during endurance racing.” Comparative Exercise Physiology 14, no. 3 (September 1, 2018): 149–59. https://doi.org/10.3920/CEP180010.Full Text
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Hershberger, Kathleen A., Dennis M. Abraham, Juan Liu, Jason W. Locasale, Paul A. Grimsrud, and Matthew D. Hirschey. “Ablation of Sirtuin5 in the postnatal mouse heart results in protein succinylation and normal survival in response to chronic pressure overload.” J Biol Chem 293, no. 27 (July 6, 2018): 10630–45. https://doi.org/10.1074/jbc.RA118.002187.Full Text Link to Item
-
Huang, He, Shuang Tang, Ming Ji, Zhanyun Tang, Miho Shimada, Xiaojing Liu, Shankang Qi, et al. “p300-Mediated Lysine 2-Hydroxyisobutyrylation Regulates Glycolysis.” Mol Cell 70, no. 5 (June 7, 2018): 984. https://doi.org/10.1016/j.molcel.2018.05.035.Full Text Link to Item
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Chapman, Nicole M., Hu Zeng, Thanh-Long M. Nguyen, Yanyan Wang, Peter Vogel, Yogesh Dhungana, Xiaojing Liu, Geoffrey Neale, Jason W. Locasale, and Hongbo Chi. “mTOR coordinates transcriptional programs and mitochondrial metabolism of activated Treg subsets to protect tissue homeostasis.” Nat Commun 9, no. 1 (May 29, 2018): 2095. https://doi.org/10.1038/s41467-018-04392-5.Full Text Link to Item
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Huang, He, Shuang Tang, Ming Ji, Zhanyun Tang, Miho Shimada, Xiaojing Liu, Shankang Qi, et al. “p300-Mediated Lysine 2-Hydroxyisobutyrylation Regulates Glycolysis.” Mol Cell 70, no. 4 (May 17, 2018): 663-678.e6. https://doi.org/10.1016/j.molcel.2018.04.011.Full Text Link to Item
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Dai, Ziwei, Samantha J. Mentch, Xia Gao, Sailendra N. Nichenametla, and Jason W. Locasale. “Methionine metabolism influences genomic architecture and gene expression through H3K4me3 peak width.” Nat Commun 9, no. 1 (May 16, 2018): 1955. https://doi.org/10.1038/s41467-018-04426-y.Full Text Link to Item
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Yan, Wei, Xiwei Wu, Weiying Zhou, Miranda Y. Fong, Minghui Cao, Juan Liu, Xiaojing Liu, et al. “Cancer-cell-secreted exosomal miR-105 promotes tumour growth through the MYC-dependent metabolic reprogramming of stromal cells.” Nat Cell Biol 20, no. 5 (May 2018): 597–609. https://doi.org/10.1038/s41556-018-0083-6.Full Text Link to Item
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Locasale, Jason W. “New concepts in feedback regulation of glucose metabolism.” Curr Opin Syst Biol 8 (April 2018): 32–38. https://doi.org/10.1016/j.coisb.2017.11.005.Full Text Link to Item
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Gao, Xia, Katie Lee, Michael A. Reid, Sydney M. Sanderson, Chuping Qiu, Siqi Li, Juan Liu, and Jason W. Locasale. “Serine Availability Influences Mitochondrial Dynamics and Function through Lipid Metabolism.” Cell Rep 22, no. 13 (March 27, 2018): 3507–20. https://doi.org/10.1016/j.celrep.2018.03.017.Full Text Link to Item
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Allen, Annamarie E., and Jason W. Locasale. “Glucose Metabolism in Cancer: The Saga of Pyruvate Kinase Continues.” Cancer Cell 33, no. 3 (March 12, 2018): 337–39. https://doi.org/10.1016/j.ccell.2018.02.008.Full Text Link to Item
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Hwang, Inah, Hwanhee Oh, Evan Santo, Do-Yeon Kim, John W. Chen, Roderick T. Bronson, Jason W. Locasale, et al. “FOXO protects against age-progressive axonal degeneration.” Aging Cell 17, no. 1 (February 2018). https://doi.org/10.1111/acel.12701.Full Text Link to Item
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Zhao, Fei, Christine Xiao, Kathy S. Evans, Tbalamayooran Theivanthiran, Nicholas DeVito, Alisha Holtzhausen, Juan Liu, et al. “Paracrine Wnt5a-β-Catenin Signaling Triggers a Metabolic Program that Drives Dendritic Cell Tolerization.” Immunity 48, no. 1 (January 16, 2018): 147-160.e7. https://doi.org/10.1016/j.immuni.2017.12.004.Full Text Open Access Copy Link to Item
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Liu, Xiaojing, Daniel E. Cooper, Ahmad A. Cluntun, Marc O. Warmoes, Steven Zhao, Michael A. Reid, Juan Liu, Kathryn E. Wellen, David G. Kirsch, and Jason W. Locasale. “De Novo Acetate Production is Coupled to Central Carbon Metabolism in Mammals,” 2018.
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Dai, Ziwei, Samantha Mentch, Xia Gao, Sailendra Nichenametla, and Jason Locasale. “Methionine metabolism influences the genomic architecture of H3K4me3 with the link to gene expression encoded in peak width,” 2018. https://doi.org/10.1101/243196.Full Text
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Dai, Ziwei, and Jason Locasale. “Thermodynamic constraints on the regulation of metabolic fluxes,” 2018. https://doi.org/10.1101/341271.Full Text
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Lu, Min, Sydney M. Sanderson, Amelia Zessin, Kathleen A. Ashcraft, Lee W. Jones, Mark W. Dewhirst, Jason W. Locasale, and David S. Hsu. “Exercise inhibits tumor growth and central carbon metabolism in patient-derived xenograft models of colorectal cancer.” Cancer Metab 6 (2018): 14. https://doi.org/10.1186/s40170-018-0190-7.Full Text Link to Item
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Sanderson, Sydney, Peter Mikhael, Ziwei Dai, and Jason Locasale. “Environmental factors shape methionine metabolism in p16/MTAP deleted cells,” 2018. https://doi.org/10.1101/313288.Full Text
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Singleton, Katherine R., Lorin Crawford, Elizabeth Tsui, Haley E. Manchester, Ophelia Maertens, Xiaojing Liu, Maria V. Liberti, et al. “Melanoma Therapeutic Strategies that Select against Resistance by Exploiting MYC-Driven Evolutionary Convergence.” Cell Rep 21, no. 10 (December 5, 2017): 2796–2812. https://doi.org/10.1016/j.celrep.2017.11.022.Full Text Link to Item
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Hershberger, Kathleen A., Dennis M. Abraham, Angelical S. Martin, Lan Mao, Juan Liu, Hongbo Gu, Jason W. Locasale, and Matthew D. Hirschey. “Sirtuin 5 is required for mouse survival in response to cardiac pressure overload.” J Biol Chem 292, no. 48 (December 1, 2017): 19767–81. https://doi.org/10.1074/jbc.M117.809897.Full Text Link to Item
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Glass, Oliver K., Michelle Bowie, Julie Fuller, David Darr, Jerry Usary, Keara Boss, Kingshuk Roy Choudhury, et al. “Differential response to exercise in claudin-low breast cancer.” Oncotarget 8, no. 60 (November 24, 2017): 100989–4. https://doi.org/10.18632/oncotarget.21054.Full Text Open Access Copy Link to Item
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Reid, Michael A., Jihye Paik, and Jason W. Locasale. “A Missing Link to Vitamin B12 Metabolism.” Cell 171, no. 4 (November 2, 2017): 736–37. https://doi.org/10.1016/j.cell.2017.10.030.Full Text Link to Item
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Tang, Shuang, Yi Fang, Gang Huang, Xiaojiang Xu, Elizabeth Padilla-Banks, Wei Fan, Qing Xu, et al. “Methionine metabolism is essential for SIRT1-regulated mouse embryonic stem cell maintenance and embryonic development.” Embo J 36, no. 21 (November 2, 2017): 3175–93. https://doi.org/10.15252/embj.201796708.Full Text Link to Item
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Reid, Michael A., Ziwei Dai, and Jason W. Locasale. “The impact of cellular metabolism on chromatin dynamics and epigenetics.” Nat Cell Biol 19, no. 11 (November 2017): 1298–1306. https://doi.org/10.1038/ncb3629.Full Text Link to Item
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Liberti, Maria V., Ziwei Dai, Suzanne E. Wardell, Joshua A. Baccile, Xiaojing Liu, Xia Gao, Robert Baldi, et al. “A Predictive Model for Selective Targeting of the Warburg Effect through GAPDH Inhibition with a Natural Product.” Cell Metab 26, no. 4 (October 3, 2017): 648-659.e8. https://doi.org/10.1016/j.cmet.2017.08.017.Full Text Link to Item
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Dai, Ziwei, and Jason W. Locasale. “Understanding metabolism with flux analysis: From theory to application.” Metab Eng 43, no. Pt B (September 2017): 94–102. https://doi.org/10.1016/j.ymben.2016.09.005.Full Text Link to Item
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Liu, Xiaojing, and Jason W. Locasale. “Biochemistry: A toxin that fuels metabolism.” Nature 548, no. 7669 (August 31, 2017): 533–34. https://doi.org/10.1038/nature23541.Full Text Link to Item
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Martin, Angelical S., Dennis M. Abraham, Kathleen A. Hershberger, Dhaval P. Bhatt, Lan Mao, Huaxia Cui, Juan Liu, et al. “Nicotinamide mononucleotide requires SIRT3 to improve cardiac function and bioenergetics in a Friedreich's ataxia cardiomyopathy model.” Jci Insight 2, no. 14 (July 20, 2017). https://doi.org/10.1172/jci.insight.93885.Full Text Link to Item
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Garcia, Jamie, Jennifer Bagwell, Brian Njaine, James Norman, Daniel S. Levic, Susan Wopat, Sara E. Miller, et al. “Sheath Cell Invasion and Trans-differentiation Repair Mechanical Damage Caused by Loss of Caveolae in the Zebrafish Notochord.” Curr Biol 27, no. 13 (July 10, 2017): 1982-1989.e3. https://doi.org/10.1016/j.cub.2017.05.035.Full Text Link to Item
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Torrano, Veronica, Lorea Valcarcel-Jimenez, Ana Rosa Cortazar, Xiaojing Liu, Jelena Urosevic, Mireia Castillo-Martin, Sonia Fernández-Ruiz, et al. “Erratum: The metabolic co-regulator PGC1α suppresses prostate cancer metastasis.” Nat Cell Biol 19, no. 7 (June 29, 2017): 873. https://doi.org/10.1038/ncb3558.Full Text Link to Item
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Liu, Xiaojing, and Jason W. Locasale. “Metabolomics reveals intratumor heterogeneity - Implications for precision medicine.” Ebiomedicine 19 (May 2017): 4–5. https://doi.org/10.1016/j.ebiom.2017.04.030.Full Text Link to Item
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Wang, Xiuxing, Kailin Yang, Qi Xie, Qiulian Wu, Stephen C. Mack, Yu Shi, Leo J. Y. Kim, et al. “Purine synthesis promotes maintenance of brain tumor initiating cells in glioma.” Nat Neurosci 20, no. 5 (May 2017): 661–73. https://doi.org/10.1038/nn.4537.Full Text Link to Item
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Gao, Xia, Michael A. Reid, Mei Kong, and Jason W. Locasale. “Metabolic interactions with cancer epigenetics.” Molecular Aspects of Medicine 54 (April 2017): 50–57. https://doi.org/10.1016/j.mam.2016.09.001.Full Text
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Liu, Xiaojing, and Jason W. Locasale. “Metabolomics: A Primer.” Trends Biochem Sci 42, no. 4 (April 2017): 274–84. https://doi.org/10.1016/j.tibs.2017.01.004.Full Text Link to Item
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Cluntun, Ahmad A., Michael J. Lukey, Richard A. Cerione, and Jason W. Locasale. “Glutamine Metabolism in Cancer: Understanding the Heterogeneity.” Trends Cancer 3, no. 3 (March 2017): 169–80. https://doi.org/10.1016/j.trecan.2017.01.005.Full Text Link to Item
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McDonald, Oliver G., Xin Li, Tyler Saunders, Rakel Tryggvadottir, Samantha J. Mentch, Marc O. Warmoes, Anna E. Word, et al. “Epigenomic reprogramming during pancreatic cancer progression links anabolic glucose metabolism to distant metastasis.” Nat Genet 49, no. 3 (March 2017): 367–76. https://doi.org/10.1038/ng.3753.Full Text Link to Item
-
Dai, Ziwei, and Jason W. Locasale. “Metabolic pattern formation in the tumor microenvironment.” Mol Syst Biol 13, no. 2 (February 9, 2017): 915. https://doi.org/10.15252/msb.20167518.Full Text Open Access Copy Link to Item
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Mattocks, Dwight A. L., Samantha J. Mentch, Jelena Shneyder, Gene P. Ables, Dongxiao Sun, John P. Richie, Jason W. Locasale, and Sailendra N. Nichenametla. “Short term methionine restriction increases hepatic global DNA methylation in adult but not young male C57BL/6J mice.” Exp Gerontol 88 (February 2017): 1–8. https://doi.org/10.1016/j.exger.2016.12.003.Full Text Link to Item
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Wang, Qian, Maria V. Liberti, Pei Liu, Xiaobing Deng, Ying Liu, Jason W. Locasale, and Luhua Lai. “Rational Design of Selective Allosteric Inhibitors of PHGDH and Serine Synthesis with Anti-tumor Activity.” Cell Chem Biol 24, no. 1 (January 19, 2017): 55–65. https://doi.org/10.1016/j.chembiol.2016.11.013.Full Text Link to Item
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Mehrmohamadi, Mahya, Seong Ho Jeong, and Jason W. Locasale. “Molecular features that predict the response to antimetabolite chemotherapies.” Cancer Metab 5 (2017): 8. https://doi.org/10.1186/s40170-017-0170-3.Full Text Link to Item
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Salerno, Stephen, Mahya Mehrmohamadi, Maria V. Liberti, Muting Wan, Martin T. Wells, James G. Booth, and Jason W. Locasale. “RRmix: A method for simultaneous batch effect correction and analysis of metabolomics data in the absence of internal standards.” Plos One 12, no. 6 (2017): e0179530. https://doi.org/10.1371/journal.pone.0179530.Full Text Link to Item
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Mehrmohamadi, Mahya, Lucas K. Mentch, Andrew G. Clark, and Jason W. Locasale. “Integrative modelling of tumour DNA methylation quantifies the contribution of metabolism.” Nat Commun 7 (December 14, 2016): 13666. https://doi.org/10.1038/ncomms13666.Full Text Link to Item
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Gao, Xia, and Jason W. Locasale. “Serine Metabolism Links Tumor Suppression to the Epigenetic Landscape.” Cell Metabolism 24, no. 6 (December 2016): 777–79. https://doi.org/10.1016/j.cmet.2016.11.012.Full Text
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Gerriets, Valerie A., Rigel J. Kishton, Marc O. Johnson, Sivan Cohen, Peter J. Siska, Amanda G. Nichols, Marc O. Warmoes, et al. “Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression.” Nat Immunol 17, no. 12 (December 2016): 1459–66. https://doi.org/10.1038/ni.3577.Full Text Link to Item
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Liu, Xiaojing, Iris L. Romero, Lacey M. Litchfield, Ernst Lengyel, and Jason W. Locasale. “Metformin Targets Central Carbon Metabolism and Reveals Mitochondrial Requirements in Human Cancers.” Cell Metab 24, no. 5 (November 8, 2016): 728–39. https://doi.org/10.1016/j.cmet.2016.09.005.Full Text Link to Item
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Pan, Min, Michael A. Reid, Xazmin H. Lowman, Rajan P. Kulkarni, Thai Q. Tran, Xiaojing Liu, Ying Yang, et al. “Regional glutamine deficiency in tumours promotes dedifferentiation through inhibition of histone demethylation.” Nat Cell Biol 18, no. 10 (October 2016): 1090–1101. https://doi.org/10.1038/ncb3410.Full Text Link to Item
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Zeng, Hu, Sivan Cohen, Cliff Guy, Sharad Shrestha, Geoffrey Neale, Scott A. Brown, Caryn Cloer, et al. “mTORC1 and mTORC2 Kinase Signaling and Glucose Metabolism Drive Follicular Helper T Cell Differentiation.” Immunity 45, no. 3 (September 20, 2016): 540–54. https://doi.org/10.1016/j.immuni.2016.08.017.Full Text Link to Item
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Dai, Ziwei, Alexander A. Shestov, Luhua Lai, and Jason W. Locasale. “A Flux Balance of Glucose Metabolism Clarifies the Requirements of the Warburg Effect.” Biophys J 111, no. 5 (September 6, 2016): 1088–1100. https://doi.org/10.1016/j.bpj.2016.07.028.Full Text Link to Item
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Reid, Michael A., Xazmin H. Lowman, Min Pan, Thai Q. Tran, Marc O. Warmoes, Mari B. Ishak Gabra, Ying Yang, Jason W. Locasale, and Mei Kong. “IKKβ promotes metabolic adaptation to glutamine deprivation via phosphorylation and inhibition of PFKFB3.” Genes Dev 30, no. 16 (August 15, 2016): 1837–51. https://doi.org/10.1101/gad.287235.116.Full Text Link to Item
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Liberti, Maria V., and Jason W. Locasale. “Metabolism: A new layer of glycolysis.” Nat Chem Biol 12, no. 8 (July 19, 2016): 577–78. https://doi.org/10.1038/nchembio.2133.Full Text Link to Item
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Ser, Zheng, Xia Gao, Christelle Johnson, Mahya Mehrmohamadi, Xiaojing Liu, Siqi Li, and Jason W. Locasale. “Targeting One Carbon Metabolism with an Antimetabolite Disrupts Pyrimidine Homeostasis and Induces Nucleotide Overflow.” Cell Rep 15, no. 11 (June 14, 2016): 2367–76. https://doi.org/10.1016/j.celrep.2016.05.035.Full Text Link to Item
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Torrano, Veronica, Lorea Valcarcel-Jimenez, Ana Rosa Cortazar, Xiaojing Liu, Jelena Urosevic, Mireia Castillo-Martin, Sonia Fernández-Ruiz, et al. “The metabolic co-regulator PGC1α suppresses prostate cancer metastasis.” Nat Cell Biol 18, no. 6 (June 2016): 645–56. https://doi.org/10.1038/ncb3357.Full Text Link to Item
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Sadhukhan, Sushabhan, Xiaojing Liu, Dongryeol Ryu, Ornella D. Nelson, John A. Stupinski, Zhi Li, Wei Chen, et al. “Metabolomics-assisted proteomics identifies succinylation and SIRT5 as important regulators of cardiac function.” Proc Natl Acad Sci U S A 113, no. 16 (April 19, 2016): 4320–25. https://doi.org/10.1073/pnas.1519858113.Full Text Link to Item
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Kishton, Rigel J., Carson E. Barnes, Amanda G. Nichols, Sivan Cohen, Valerie A. Gerriets, Peter J. Siska, Andrew N. Macintyre, et al. “AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival.” Cell Metab 23, no. 4 (April 12, 2016): 649–62. https://doi.org/10.1016/j.cmet.2016.03.008.Full Text Link to Item
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Park, Sunghee, Ching-Yi Chang, Rachid Safi, Xiaojing Liu, Robert Baldi, Jeff S. Jasper, Grace R. Anderson, et al. “ERRα-Regulated Lactate Metabolism Contributes to Resistance to Targeted Therapies in Breast Cancer.” Cell Rep 15, no. 2 (April 12, 2016): 323–35. https://doi.org/10.1016/j.celrep.2016.03.026.Full Text Link to Item
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Jurkowska, Halina, Julie Niewiadomski, Lawrence L. Hirschberger, Heather B. Roman, Kevin M. Mazor, Xiaojing Liu, Jason W. Locasale, Eunkyue Park, and Martha H. Stipanuk. “Downregulation of hepatic betaine:homocysteine methyltransferase (BHMT) expression in taurine-deficient mice is reversed by taurine supplementation in vivo.” Amino Acids 48, no. 3 (March 2016): 665–76. https://doi.org/10.1007/s00726-015-2108-9.Full Text Link to Item
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Liberti, Maria V., and Jason W. Locasale. “The Warburg Effect: How Does it Benefit Cancer Cells?” Trends Biochem Sci 41, no. 3 (March 2016): 211–18. https://doi.org/10.1016/j.tibs.2015.12.001.Full Text Link to Item
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Liberti, Maria V., and Jason W. Locasale. “Correction to: 'The Warburg Effect: How Does it Benefit Cancer Cells?': [Trends in Biochemical Sciences, 41 (2016) 211].” Trends Biochem Sci 41, no. 3 (March 2016): 287. https://doi.org/10.1016/j.tibs.2016.01.004.Full Text Link to Item
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Sumita, Kazutaka, Yu-Hua Lo, Koh Takeuchi, Miki Senda, Satoshi Kofuji, Yoshiki Ikeda, Jumpei Terakawa, et al. “The Lipid Kinase PI5P4Kβ Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis.” Mol Cell 61, no. 2 (January 21, 2016): 187–98. https://doi.org/10.1016/j.molcel.2015.12.011.Full Text Link to Item
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Chiyoda, Tatsuyuki, Xiaojing Liu, Ernst Lengyel, Jason Locasale, and Iris Romero. “Abstract A68: Sphingosine kinase 1 as a mediator and predictor of metformin's protective effect in ovarian cancer.” Clinical Cancer Research 22, no. 2_Supplement (January 15, 2016): A68–A68. https://doi.org/10.1158/1557-3265.ovca15-a68.Full Text
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Mentch, Samantha J., and Jason W. Locasale. “One-carbon metabolism and epigenetics: understanding the specificity.” Ann N Y Acad Sci 1363, no. 1 (January 2016): 91–98. https://doi.org/10.1111/nyas.12956.Full Text Link to Item
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Niewiadomski, Julie, James Q. Zhou, Heather B. Roman, Xiaojing Liu, Lawrence L. Hirschberger, Jason W. Locasale, and Martha H. Stipanuk. “Effects of a block in cysteine catabolism on energy balance and fat metabolism in mice.” Ann N Y Acad Sci 1363, no. 1 (January 2016): 99–115. https://doi.org/10.1111/nyas.13021.Full Text Link to Item
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Barker, Brandon E., Narayanan Sadagopan, Yiping Wang, Kieran Smallbone, Christopher R. Myers, Hongwei Xi, Jason W. Locasale, and Zhenglong Gu. “A robust and efficient method for estimating enzyme complex abundance and metabolic flux from expression data.” Comput Biol Chem 59 Pt B, no. 0 0 (December 2015): 98–112. https://doi.org/10.1016/j.compbiolchem.2015.08.002.Full Text Link to Item
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Block, Keith I., Charlotte Gyllenhaal, Leroy Lowe, Amedeo Amedei, ARM Ruhul Amin, Amr Amin, Katia Aquilano, et al. “Designing a broad-spectrum integrative approach for cancer prevention and treatment.” Semin Cancer Biol 35 Suppl, no. Suppl (December 2015): S276–304. https://doi.org/10.1016/j.semcancer.2015.09.007.Full Text Link to Item
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Hirschey, Matthew D., Ralph J. DeBerardinis, Anna Mae E. Diehl, Janice E. Drew, Christian Frezza, Michelle F. Green, Lee W. Jones, et al. “Dysregulated metabolism contributes to oncogenesis.” Semin Cancer Biol 35 Suppl (December 2015): S129–50. https://doi.org/10.1016/j.semcancer.2015.10.002.Full Text Link to Item
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Mentch, Samantha J., Mahya Mehrmohamadi, Lei Huang, Xiaojing Liu, Diwakar Gupta, Dwight Mattocks, Paola Gómez Padilla, et al. “Histone Methylation Dynamics and Gene Regulation Occur through the Sensing of One-Carbon Metabolism.” Cell Metab 22, no. 5 (November 3, 2015): 861–73. https://doi.org/10.1016/j.cmet.2015.08.024.Full Text Link to Item
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Colak, Gozde, Olga Pougovkina, Lunzhi Dai, Minjia Tan, Heleen Te Brinke, He Huang, Zhongyi Cheng, et al. “Proteomic and Biochemical Studies of Lysine Malonylation Suggest Its Malonic Aciduria-associated Regulatory Role in Mitochondrial Function and Fatty Acid Oxidation.” Mol Cell Proteomics 14, no. 11 (November 2015): 3056–71. https://doi.org/10.1074/mcp.M115.048850.Full Text Link to Item
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Mehrmohamadi, Mahya, and Jason W. Locasale. “Context dependent utilization of serine in cancer.” Mol Cell Oncol 2, no. 4 (October 1, 2015): e996418. https://doi.org/10.1080/23723556.2014.996418.Full Text Link to Item
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Douris, Nicholas, Tamar Melman, Jordan M. Pecherer, Pavlos Pissios, Jeffrey S. Flier, Lewis C. Cantley, Jason W. Locasale, and Eleftheria Maratos-Flier. “Adaptive changes in amino acid metabolism permit normal longevity in mice consuming a low-carbohydrate ketogenic diet.” Biochim Biophys Acta 1852, no. 10 Pt A (October 2015): 2056–65. https://doi.org/10.1016/j.bbadis.2015.07.009.Full Text Link to Item
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Ho, Ping-Chih, Jessica Dauz Bihuniak, Andrew N. Macintyre, Matthew Staron, Xiaojing Liu, Robert Amezquita, Yao-Chen Tsui, et al. “Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses.” Cell 162, no. 6 (September 10, 2015): 1217–28. https://doi.org/10.1016/j.cell.2015.08.012.Full Text Link to Item
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Chourasia, Aparajita H., Kristin Tracy, Casey Frankenberger, Michelle L. Boland, Marina N. Sharifi, Lauren E. Drake, Joseph R. Sachleben, et al. “Mitophagy defects arising from BNip3 loss promote mammary tumor progression to metastasis.” Embo Rep 16, no. 9 (September 2015): 1145–63. https://doi.org/10.15252/embr.201540759.Full Text Link to Item
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Buescher, Joerg M., Maciek R. Antoniewicz, Laszlo G. Boros, Shawn C. Burgess, Henri Brunengraber, Clary B. Clish, Ralph J. DeBerardinis, et al. “A roadmap for interpreting (13)C metabolite labeling patterns from cells.” Curr Opin Biotechnol 34 (August 2015): 189–201. https://doi.org/10.1016/j.copbio.2015.02.003.Full Text Link to Item
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Simões, Rui V., Inna S. Serganova, Natalia Kruchevsky, Avigdor Leftin, Alexander A. Shestov, Howard T. Thaler, George Sukenick, et al. “Metabolic plasticity of metastatic breast cancer cells: adaptation to changes in the microenvironment.” Neoplasia 17, no. 8 (August 2015): 671–84. https://doi.org/10.1016/j.neo.2015.08.005.Full Text Link to Item
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Liu, Xiaojing, Sushabhan Sadhukhan, Shengyi Sun, Gregory R. Wagner, Matthew D. Hirschey, Ling Qi, Hening Lin, and Jason W. Locasale. “High-Resolution Metabolomics with Acyl-CoA Profiling Reveals Widespread Remodeling in Response to Diet.” Mol Cell Proteomics 14, no. 6 (June 2015): 1489–1500. https://doi.org/10.1074/mcp.M114.044859.Full Text Link to Item
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Ser, Zheng, Xiaojing Liu, Ngoc Nu Tang, and Jason W. Locasale. “Extraction parameters for metabolomics from cultured cells.” Anal Biochem 475 (April 15, 2015): 22–28. https://doi.org/10.1016/j.ab.2015.01.003.Full Text Link to Item
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Chen, Jinyu, Ho-Jeong Lee, Xuefeng Wu, Lei Huo, Sun-Jin Kim, Lei Xu, Yan Wang, et al. “Gain of glucose-independent growth upon metastasis of breast cancer cells to the brain.” Cancer Res 75, no. 3 (February 1, 2015): 554–65. https://doi.org/10.1158/0008-5472.CAN-14-2268.Full Text Link to Item
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Johnson, Christelle, Marc O. Warmoes, Xiling Shen, and Jason W. Locasale. “Epigenetics and cancer metabolism.” Cancer Lett 356, no. 2 Pt A (January 28, 2015): 309–14. https://doi.org/10.1016/j.canlet.2013.09.043.Full Text Link to Item
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Cluntun, Ahmad A., He Huang, Lunzhi Dai, Xiaojing Liu, Yingming Zhao, and Jason W. Locasale. “The rate of glycolysis quantitatively mediates specific histone acetylation sites.” Cancer Metab 3 (2015): 10. https://doi.org/10.1186/s40170-015-0135-3.Full Text Link to Item
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Crowe, Kristi M., David Allison, and David Bioactive Food Components Conference Speakers. “Evaluating bioactive food components in obesity and cancer prevention.” Crit Rev Food Sci Nutr 55, no. 5 (2015): 732–34. https://doi.org/10.1080/10408398.2013.878305.Full Text Link to Item
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Gerriets, Valerie A., Rigel J. Kishton, Amanda G. Nichols, Andrew N. Macintyre, Makoto Inoue, Olga Ilkayeva, Peter S. Winter, et al. “Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation.” J Clin Invest 125, no. 1 (January 2015): 194–207. https://doi.org/10.1172/JCI76012.Full Text Open Access Copy Link to Item
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Madhukar, Neel S., Marc O. Warmoes, and Jason W. Locasale. “Organization of enzyme concentration across the metabolic network in cancer cells.” Plos One 10, no. 1 (2015): e0117131. https://doi.org/10.1371/journal.pone.0117131.Full Text Link to Item
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Mehrmohamadi, Mahya, Xiaojing Liu, Alexander A. Shestov, and Jason W. Locasale. “Characterization of the usage of the serine metabolic network in human cancer.” Cell Rep 9, no. 4 (November 20, 2014): 1507–19. https://doi.org/10.1016/j.celrep.2014.10.026.Full Text Link to Item
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Huang, Lei, Dongsung Kim, Xiaojing Liu, Christopher R. Myers, and Jason W. Locasale. “Estimating relative changes of metabolic fluxes.” Plos Comput Biol 10, no. 11 (November 2014): e1003958. https://doi.org/10.1371/journal.pcbi.1003958.Full Text Link to Item
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Warmoes, Marc O., and Jason W. Locasale. “Heterogeneity of glycolysis in cancers and therapeutic opportunities.” Biochem Pharmacol 92, no. 1 (November 1, 2014): 12–21. https://doi.org/10.1016/j.bcp.2014.07.019.Full Text Link to Item
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“Glucose transporter 1-mediated glucose uptake is limiting for B-cell acute lymphoblastic leukemia anabolic metabolism and resistance to apoptosis.” Cell Death & Disease 5, no. 11 (November 2014): e1516-. https://doi.org/10.1038/cddis.2014.493.Full Text
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Liu, T., R. J. Kishton, A. N. Macintyre, V. A. Gerriets, H. Xiang, X. Liu, E. D. Abel, D. Rizzieri, J. W. Locasale, and J. C. Rathmell. “Glucose transporter 1-mediated glucose uptake is limiting for B-cell acute lymphoblastic leukemia anabolic metabolism and resistance to apoptosis.” Cell Death Dis 5, no. 10 (October 16, 2014): e1470. https://doi.org/10.1038/cddis.2014.431.Full Text Link to Item
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Shestov, Alexander A., Xiaojing Liu, Zheng Ser, Ahmad A. Cluntun, Yin P. Hung, Lei Huang, Dongsung Kim, et al. “Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step.” Elife 3 (July 9, 2014). https://doi.org/10.7554/eLife.03342.Full Text Link to Item
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Liu, Xiaojing, Zheng Ser, Ahmad A. Cluntun, Samantha J. Mentch, and Jason W. Locasale. “A strategy for sensitive, large scale quantitative metabolomics.” J Vis Exp, no. 87 (May 27, 2014). https://doi.org/10.3791/51358.Full Text Link to Item
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Dasgupta, Tathagata, David H. Croll, Jeremy A. Owen, Matthew G. Vander Heiden, Jason W. Locasale, Uri Alon, Lewis C. Cantley, and Jeremy Gunawardena. “A fundamental trade-off in covalent switching and its circumvention by enzyme bifunctionality in glucose homeostasis.” J Biol Chem 289, no. 19 (May 9, 2014): 13010–25. https://doi.org/10.1074/jbc.M113.546515.Full Text Link to Item
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Sun, S., G. Shi, X. Han, A. B. Francisco, Y. Ji, N. Mendonça, X. Liu, et al. “Erratum: Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation, endoplasmic reticulum homeostasis, and survival (Proceedings of the National Academy of Sciences of the United States of America (2014) 111, 5, (E582-E591) doi:10.1073/pnas.1318114111).” Proceedings of the National Academy of Sciences of the United States of America 111, no. 16 (April 22, 2014): 6115. https://doi.org/10.1073/pnas.1405563111.Full Text
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Liu, Xiaojing, Zheng Ser, and Jason W. Locasale. “Development and quantitative evaluation of a high-resolution metabolomics technology.” Anal Chem 86, no. 4 (February 18, 2014): 2175–84. https://doi.org/10.1021/ac403845u.Full Text Link to Item
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Sun, Shengyi, Guojun Shi, Xuemei Han, Adam B. Francisco, Yewei Ji, Nuno Mendonça, Xiaojing Liu, et al. “Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation, endoplasmic reticulum homeostasis, and survival.” Proc Natl Acad Sci U S A 111, no. 5 (February 4, 2014): E582–91. https://doi.org/10.1073/pnas.1318114111.Full Text Link to Item
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Johnson, Christelle, Kai-Yuan Chen, Xiaojing Liu, Pengcheng Bu, Jason Locasale, and Xiling Shen. “A metabolic signature of colon cancer initiating cells.” Cancer & Metabolism 2, no. Suppl 1 (January 2014): P32–P32. https://doi.org/10.1186/2049-3002-2-s1-p32.Full Text
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Chen, Kai-Yuan, Xiaojing Liu, Pengcheng Bu, Chieh-Sheng Lin, Nikolai Rakhilin, Jason W. Locasale, and Xiling Shen. “A metabolic signature of colon cancer initiating cells.” Annu Int Conf Ieee Eng Med Biol Soc 2014 (2014): 4759–62. https://doi.org/10.1109/EMBC.2014.6944688.Full Text Link to Item
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Liu, T., R. J. Kishton, A. N. Macintyre, V. A. Gerriets, H. Xiang, X. Liu, E. D. Abel, D. Rizzieri, J. W. Locasale, and J. C. Rathmell. “Glucose transporter 1-mediated glucose uptake is limiting for B-cell acute lymphoblastic leukemia anabolic metabolism and resistance to apoptosis.” Cell Death Dis 5 (2014): e1516. https://doi.org/10.1038/cddis.2014.493.Full Text Link to Item
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Parkhitko, Andrey A., Carmen Priolo, Jonathan L. Coloff, Jihye Yun, Julia J. Wu, Kenji Mizumura, Wenping Xu, et al. “Autophagy-dependent metabolic reprogramming sensitizes TSC2-deficient cells to the antimetabolite 6-aminonicotinamide.” Mol Cancer Res 12, no. 1 (January 2014): 48–57. https://doi.org/10.1158/1541-7786.MCR-13-0258-T.Full Text Link to Item
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Shestov, Alexander A., Xiaojing Liu, Zheng Ser, Ahmad A. Cluntun, Yin P. Hung, Lei Huang, Dongsung Kim, et al. “Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step.” Elife 3 (2014). https://doi.org/10.7554/eLife.03342.Full Text Link to Item
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Locasale, Jason W. “Serine, glycine and one-carbon units: cancer metabolism in full circle.” Nat Rev Cancer 13, no. 8 (August 2013): 572–83. https://doi.org/10.1038/nrc3557.Full Text Link to Item
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Hu, Jie, Jason W. Locasale, Jason H. Bielas, Jacintha O’Sullivan, Kieran Sheahan, Lewis C. Cantley, Matthew G. Vander Heiden, and Dennis Vitkup. “Heterogeneity of tumor-induced gene expression changes in the human metabolic network.” Nat Biotechnol 31, no. 6 (June 2013): 522–29. https://doi.org/10.1038/nbt.2530.Full Text Link to Item
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Shyh-Chang, Ng, Jason W. Locasale, Costas A. Lyssiotis, Yuxiang Zheng, Ren Yi Teo, Sutheera Ratanasirintrawoot, Jin Zhang, et al. “Influence of threonine metabolism on S-adenosylmethionine and histone methylation.” Science 339, no. 6116 (January 11, 2013): 222–26. https://doi.org/10.1126/science.1226603.Full Text Link to Item
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Baker, Rachael, Steven M. Lewis, Atsuo T. Sasaki, Emily M. Wilkerson, Jason W. Locasale, Lewis C. Cantley, Brian Kuhlman, Henrik G. Dohlman, and Sharon L. Campbell. “Site-specific monoubiquitination activates Ras by impeding GTPase-activating protein function.” Nat Struct Mol Biol 20, no. 1 (January 2013): 46–52. https://doi.org/10.1038/nsmb.2430.Full Text Link to Item
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Shestov, Alexander A., Brandon Barker, Zhenglong Gu, and Jason W. Locasale. “Computational approaches for understanding energy metabolism.” Wiley Interdiscip Rev Syst Biol Med 5, no. 6 (2013): 733–50. https://doi.org/10.1002/wsbm.1238.Full Text Link to Item
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Locasale, Jason W. “The consequences of enhanced cell-autonomous glucose metabolism.” Trends Endocrinol Metab 23, no. 11 (November 2012): 545–51. https://doi.org/10.1016/j.tem.2012.07.005.Full Text Link to Item
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Locasale, Jason W. “Metabolic rewiring drives resistance to targeted cancer therapy.” Mol Syst Biol 8 (July 17, 2012): 597. https://doi.org/10.1038/msb.2012.30.Full Text Link to Item
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Locasale, Jason W., Tamar Melman, Susan Song, Xuemei Yang, Kenneth D. Swanson, Lewis C. Cantley, Eric T. Wong, and John M. Asara. “Metabolomics of human cerebrospinal fluid identifies signatures of malignant glioma.” Mol Cell Proteomics 11, no. 6 (June 2012): M111.014688. https://doi.org/10.1074/mcp.M111.014688.Full Text Link to Item
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Ying, Haoqiang, Alec C. Kimmelman, Costas A. Lyssiotis, Sujun Hua, Gerald C. Chu, Eliot Fletcher-Sananikone, Jason W. Locasale, et al. “Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism.” Cell 149, no. 3 (April 27, 2012): 656–70. https://doi.org/10.1016/j.cell.2012.01.058.Full Text Link to Item
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Lyssiotis, C. A., D. Anastasiou, J. W. Locasale, M. G. Vander Heiden, H. R. Christofk, and L. C. Cantley. “Cellular control mechanisms that regulate pyruvate kinase M2 activity and promote cancer growth.” Biomedical Research 23, no. SPEC. ISSUE (February 23, 2012): 213–17.
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Locasale, Jason W., and Benjamin J. Zeskind. “Maximizing the efficacy of angiogenesis inhibitors.” J Clin Oncol 30, no. 3 (January 20, 2012): 337–38. https://doi.org/10.1200/JCO.2011.38.5435.Full Text Link to Item
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Locasale, Jason W., Alexandra Grassian, Rameen Beroukhim, Matthew Meyerson, Gerhard Wagner, John M. Asara, Joan S. Brugge, Matthew G. Vander Heiden, and Lewis C. Cantley. “Amplification of phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis.” Bmc Proceedings 6, no. Suppl 3 (January 2012): O15–O15. https://doi.org/10.1186/1753-6561-6-s3-o15.Full Text
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Yun, Jihye, Jared L. Johnson, Christin L. Hanigan, and Jason W. Locasale. “Interactions between epigenetics and metabolism in cancers.” Front Oncol 2 (2012): 163. https://doi.org/10.3389/fonc.2012.00163.Full Text Link to Item
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Locasale, Jason W., and Benjamin Zeskind. “IL-6 and ovarian cancer--letter.” Clin Cancer Res 17, no. 24 (December 15, 2011): 7837. https://doi.org/10.1158/1078-0432.CCR-11-2170.Full Text Link to Item
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Shyh-Chang, Ng, Yuxiang Zheng, Jason W. Locasale, and Lewis C. Cantley. “Human pluripotent stem cells decouple respiration from energy production.” Embo J 30, no. 24 (December 14, 2011): 4851–52. https://doi.org/10.1038/emboj.2011.436.Full Text Link to Item
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Anastasiou, Dimitrios, George Poulogiannis, John M. Asara, Matthew B. Boxer, Jian-kang Jiang, Min Shen, Gary Bellinger, et al. “Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses.” Science 334, no. 6060 (December 2, 2011): 1278–83. https://doi.org/10.1126/science.1211485.Full Text Link to Item
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Mullarky, Edouard, Katherine R. Mattaini, Matthew G. Vander Heiden, Lewis C. Cantley, and Jason W. Locasale. “PHGDH amplification and altered glucose metabolism in human melanoma.” Pigment Cell Melanoma Res 24, no. 6 (December 2011): 1112–15. https://doi.org/10.1111/j.1755-148X.2011.00919.x.Full Text Link to Item
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Locasale, Jason W., and Lewis C. Cantley. “Genetic selection for enhanced serine metabolism in cancer development.” Cell Cycle 10, no. 22 (November 15, 2011): 3812–13. https://doi.org/10.4161/cc.10.22.18224.Full Text Link to Item
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Locasale, Jason W., Tamar Melman, Susan S. Song, Xuemei Yang, Kenneth D. Swanson, Lewis C. Cantley, John M. Asara, and Eric T. Wong. “METABOLOMICS PROFILING OF PATIENT CEREBROSPINAL FLUID IDENTIFIES SIGNATURES OF MALIGNANT GLIOMA.” Neuro Oncology 13 (November 1, 2011): 69–69.Link to Item
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Adams, Seray, Nady Braidy, Charlie Teo, Gilles Guillemin, Metellus Philippe, Colin Carole, Taieb David, et al. “METABOLIC PATHWAYS.” Neuro Oncology 13, no. Suppl 3 (November 2011): iii69–72.
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Gao, Daming, Hiroyuki Inuzuka, Meng-Kwang Marcus Tan, Hidefumi Fukushima, Jason W. Locasale, Pengda Liu, Lixin Wan, et al. “mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR.” Mol Cell 44, no. 2 (October 21, 2011): 290–303. https://doi.org/10.1016/j.molcel.2011.08.030.Full Text Link to Item
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Locasale, Jason W., and Lewis C. Cantley. “Metabolic flux and the regulation of mammalian cell growth.” Cell Metab 14, no. 4 (October 5, 2011): 443–51. https://doi.org/10.1016/j.cmet.2011.07.014.Full Text Link to Item
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Yi, Caroline H., Heling Pan, Jan Seebacher, Il-Ho Jang, Sven G. Hyberts, Gregory J. Heffron, Matthew G. Vander Heiden, et al. “Metabolic regulation of protein N-alpha-acetylation by Bcl-xL promotes cell survival.” Cell 146, no. 4 (August 19, 2011): 607–20. https://doi.org/10.1016/j.cell.2011.06.050.Full Text Link to Item
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Locasale, Jason W., Alexandra R. Grassian, Tamar Melman, Costas A. Lyssiotis, Katherine R. Mattaini, Adam J. Bass, Gregory Heffron, et al. “Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis.” Nat Genet 43, no. 9 (July 31, 2011): 869–74. https://doi.org/10.1038/ng.890.Full Text Link to Item
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CANTLEY LEWIS C, James Richard, James Richard VANDER HEIDEN MATTHEW, James Richard LOCASALE JASON, and James Richard SHARFI HADAR. “METHODS AND COMPOSITIONS FOR THE DIAGNOSIS AND TREATMENT OF CELLULAR PROLIFERATIVE DISORDERS,” May 26, 2011.
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Yang, Xuemei, Jason Locasale, Rami Rahal, Susanne Breitkopf, Matthew VanderHeiden, Dimitrios Spentzos, Chin-Lee Wu, et al. “Abstract LB-255: A mass spectrometry platform to quantitatively profile cancer cell metabolism from cells, tumors, and fixed tissue.” Cancer Research 71, no. 8_Supplement (April 15, 2011). https://doi.org/10.1158/1538-7445.am2011-lb-255.Full Text
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Sasaki, Atsuo T., Arkaitz Carracedo, Jason W. Locasale, Dimitrios Anastasiou, Koh Takeuchi, Emily Rose Kahoud, Sasson Haviv, John M. Asara, Pier Paolo Pandolfi, and Lewis C. Cantley. “Ubiquitination of K-Ras enhances activation and facilitates binding to select downstream effectors.” Sci Signal 4, no. 163 (March 8, 2011): ra13. https://doi.org/10.1126/scisignal.2001518.Full Text Link to Item
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Vander Heiden, M. G., S. Y. Lunt, T. L. Dayton, B. P. Fiske, W. J. Israelsen, K. R. Mattaini, N. I. Vokes, et al. “Metabolic pathway alterations that support cell proliferation.” Cold Spring Harb Symp Quant Biol 76 (2011): 325–34. https://doi.org/10.1101/sqb.2012.76.010900.Full Text Link to Item
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Locasale, Jason W., Matthew G. Vander Heiden, and Lewis C. Cantley. “Rewiring of glycolysis in cancer cell metabolism.” Cell Cycle 9, no. 21 (November 1, 2010): 4253. https://doi.org/10.4161/cc.9.21.13925.Full Text Link to Item
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Vander Heiden, Matthew G., Jason W. Locasale, Kenneth D. Swanson, Hadar Sharfi, Greg J. Heffron, Daniel Amador-Noguez, Heather R. Christofk, et al. “Evidence for an alternative glycolytic pathway in rapidly proliferating cells.” Science 329, no. 5998 (September 17, 2010): 1492–99. https://doi.org/10.1126/science.1188015.Full Text Link to Item
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Yang, X., R. Rahal, J. Locasale, S. Song, L. Cantley, E. Wong, N. Perrimon, M. Vander Heiden, and J. Asara. “A Mass Spectrometry Platform to Quantitatively Profile Cancer Cell Metabolism from Cell Lines to Tissues.” Journal of Biomolecular Techniques : Jbt 21, no. 3 Suppl (September 2010): S39–40.
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Locasale, Jason W., and Lewis C. Cantley. “Altered metabolism in cancer.” Bmc Biol 8 (June 25, 2010): 88. https://doi.org/10.1186/1741-7007-8-88.Full Text Link to Item
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Prisic, Sladjana, Selasi Dankwa, Daniel Schwartz, Michael F. Chou, Jason W. Locasale, Choong-Min Kang, Guy Bemis, George M. Church, Hanno Steen, and Robert N. Husson. “Extensive phosphorylation with overlapping specificity by Mycobacterium tuberculosis serine/threonine protein kinases.” Proc Natl Acad Sci U S A 107, no. 16 (April 20, 2010): 7521–26. https://doi.org/10.1073/pnas.0913482107.Full Text Link to Item
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Locasale, Jason W., Lewis C. Cantley, and Matthew G. Vander Heiden. “Cancer's insatiable appetite.” Nat Biotechnol 27, no. 10 (October 2009): 916–17. https://doi.org/10.1038/nbt1009-916.Full Text Link to Item
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Locasale, Jason W., and Alejandro Wolf-Yadlin. “Maximum entropy reconstructions of dynamic signaling networks from quantitative proteomics data.” Plos One 4, no. 8 (August 26, 2009): e6522. https://doi.org/10.1371/journal.pone.0006522.Full Text Link to Item
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Locasale, Jason W., Andrew A. Napoli, Shengfeng Chen, Helen M. Berman, and Catherine L. Lawson. “Signatures of protein-DNA recognition in free DNA binding sites.” J Mol Biol 386, no. 4 (March 6, 2009): 1054–65. https://doi.org/10.1016/j.jmb.2009.01.007.Full Text Link to Item
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Locasale, Jason W. “Signal duration and the time scale dependence of signal integration in biochemical pathways.” Bmc Syst Biol 2 (December 17, 2008): 108. https://doi.org/10.1186/1752-0509-2-108.Full Text Link to Item
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Locasale, Jason W. “Three-state kinetic mechanism for scaffold-mediated signal transduction.” Phys Rev E Stat Nonlin Soft Matter Phys 78, no. 5 Pt 1 (November 2008): 051921. https://doi.org/10.1103/PhysRevE.78.051921.Full Text Link to Item
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Locasale, Jason W., and Arup K. Chakraborty. “Regulation of signal duration and the statistical dynamics of kinase activation by scaffold proteins.” Plos Comput Biol 4, no. 6 (June 27, 2008): e1000099. https://doi.org/10.1371/journal.pcbi.1000099.Full Text Link to Item
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Locasale, Jason W., and Arup K. Chakraborty. “Importance of signal duration and the time scale dependence of signal integration in biochemical networks.” Faseb Journal 22 (April 1, 2008).Link to Item
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Locasale, Jason W. “Allovalency revisited: an analysis of multisite phosphorylation and substrate rebinding.” J Chem Phys 128, no. 11 (March 21, 2008): 115106. https://doi.org/10.1063/1.2841124.Full Text Link to Item
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Locasale, Jason W. “Scaffold proteins tune the regulatory properties of protein kinase cascades.” Abstracts of Papers of the American Chemical Society 234 (August 19, 2007).Link to Item
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Locasale, Jason W., Andrey S. Shaw, and Arup K. Chakraborty. “Scaffold proteins confer diverse regulatory properties to protein kinase cascades.” Proc Natl Acad Sci U S A 104, no. 33 (August 14, 2007): 13307–12. https://doi.org/10.1073/pnas.0706311104.Full Text Link to Item
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Locasale, Jason W. “Computational investigations into the origins of short-term biochemical memory in T cell activation.” Plos One 2, no. 7 (July 18, 2007): e627. https://doi.org/10.1371/journal.pone.0000627.Full Text Link to Item
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Cemerski, Saso, Jayajit Das, Jason Locasale, Phoebe Arnold, Emanuele Giurisato, Mary A. Markiewicz, Daved Fremont, Paul M. Allen, Arup K. Chakraborty, and Andrey S. Shaw. “The stimulatory potency of T cell antigens is influenced by the formation of the immunological synapse.” Immunity 26, no. 3 (March 2007): 345–55. https://doi.org/10.1016/j.immuni.2007.01.013.Full Text Link to Item
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Book Sections
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Reid, M. A., S. M. Sanderson, and J. W. Locasale. “Cancer Metabolism.” In Abeloff’s Clinical Oncology, 127-138.e4, 2019. https://doi.org/10.1016/B978-0-323-47674-4.00009-8.Full Text
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Anastasiou, D., J. W. Locasale, and M. G. Vander Heiden. “Cancer metabolism.” In Systems Biology of Cancer, 295–308, 2015. https://doi.org/10.1017/9780511979811.020.Full Text
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Patnaik, A., J. W. Locasale, and L. C. Cantley. “Cancer cell metabolism.” In Insulin-like Growth Factors and Cancer: From Basic Biology to Therapeutics, 245–61, 2012. https://doi.org/10.1007/978-1-4614-0598-6_13.Full Text
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Conference Papers
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Kim, Leo J. Y., Esther W. Lim, Jason W. Locasale, Andrew E. Sloan, Christian M. Metallo, and Jeremy N. Rich. “Reprogrammed TCA Cycle Maintains a Stem-Like Epitranscriptome and Therapeutic Persistence in Glioblastoma Stem Cells.” In Journal of Neurosurgery, 132:123–123. AMER ASSOC NEUROLOGICAL SURGEONS, 2020.Link to Item
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Liu, Xiaojing, Daniel E. Cooper, Ahmad A. Cluntun, Marc O. Warmoes, Steven Zhao, Michael A. Reid, Juan Liu, et al. “Abstract 792: Acetate production from glucose and coupling to mitochondrial metabolism in mammals.” In Molecular and Cellular Biology / Genetics. American Association for Cancer Research, 2019. https://doi.org/10.1158/1538-7445.sabcs18-792.Full Text
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Ma, Hong, Shuo Yu, Xiaojing Liu, Yingao Zhang, Thomas Fakadej, Ziqing Liu, Chaoying Yin, et al. “Lin28a Regulates Pathological Cardiac Hypertrophic Growth through Pck2-mediated Enhancement of Anabolic Synthesis.” In Faseb Journal, Vol. 33. WILEY, 2019.Link to Item
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Ma, Hong, Shuo Yu, Xiaojing Liu, Yingao Zhang, Thomas Fakadej, Ziqing Liu, Chaoying Yin, et al. “Abstract 415: Lin28a Regulates Pathological Cardiac Hypertrophic Growth Through Pck2-mediated Enhancement of Anabolic Synthesis.” In Circulation Research, Vol. 123. Ovid Technologies (Wolters Kluwer Health), 2018. https://doi.org/10.1161/res.123.suppl_1.415.Full Text
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Hart, Peter C., Tatsuyuki Chiyoda, Marion Curtis, Xiaojing Liu, Chun-Yi Chiang, Stephanie McGregor, Ricardo Lastra, Jason Locasale, Ernst Lengyel, and Iris L. Romero. “Abstract 5474: Activity of the S1P pathway promotes ovarian cancer and serves as a novel metabolic target of metformin.” In Cancer Research, 78:5474–5474. American Association for Cancer Research (AACR), 2018. https://doi.org/10.1158/1538-7445.am2018-5474.Full Text
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Lee, Jiyoung, Ali Yesilkanal, Casey Frankenberger, Mohamad Elbaz, Daniel Rabe, Jielin Yan, Felicia Rustandy, et al. “Abstract 5497: Effective combination therapy for breast cancer targeting BACH1 and mitochondrial metabolism.” In Cancer Research, 78:5497–5497. American Association for Cancer Research (AACR), 2018. https://doi.org/10.1158/1538-7445.am2018-5497.Full Text
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Liberti, Maria V., Ziwei Dai, Suzanne E. Wardell, Joshua A. Baccile, Xiaojing Liu, Xia Gao, Robert Baldi, et al. “Abstract 5496: A predictive model for selective targeting of the Warburg effect through GAPDH inhibition with a natural product.” In Cancer Research, 78:5496–5496. American Association for Cancer Research (AACR), 2018. https://doi.org/10.1158/1538-7445.am2018-5496.Full Text
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Sanderson, Sydney M., Peter Mikhael, Ziwei Dai, and Jason W. Locasale. “Abstract 388: p16/MTAP status as a model for investigating gene-environment interactions in metabolism.” In Cancer Research, 78:388–388. American Association for Cancer Research (AACR), 2018. https://doi.org/10.1158/1538-7445.am2018-388.Full Text
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Garcia, J. N., J. Bagwell, B. Njaine, J. Norman, D. Levic, S. Wopat, S. Miller, et al. “Sheath Cell Invasion and Trans-differentiation Repair Mechanical Damage Caused by Loss of Caveolae in the Zebrafish Notochord.” In Molecular Biology of the Cell, Vol. 28. AMER SOC CELL BIOLOGY, 2017.Link to Item
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Valcarcel, L., V. Torrano, A. R. Cortazar, X. Liu, J. Urosevic, M. Castillo, G. Morciano, et al. “Transcriptional regulation of prostate cancer metabolism.” In European Journal of Cancer, 61:S171–S171. Elsevier BV, 2016. https://doi.org/10.1016/s0959-8049(16)61606-4.Full Text
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O-Sullivan, Insug, Zakaria Sibai, Wenwei Zhang, Jason Locasale, Douglas G. Mashek, and Terry G. Unterman. “Fox01 Promotes Glucose Intolerance in Liver-specific Insulin Receptor Knockout (LIRKO) Mice by Regulating ATGL-dependent Lipo lysis and Fatty Acid Oxidation.” In Diabetes, 65:A67–A67. AMER DIABETES ASSOC, 2016.Link to Item
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Liu, Xiaojing, Ernst Lengyel, Iris Romero, and Jason Locasale. “Metformin acts to disrupt mitochondrial-associated metabolic homeostasis in human cancer.” In Abstracts of Papers of the American Chemical Society, Vol. 250. AMER CHEMICAL SOC, 2015.Link to Item
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Romero, Iris L., Xiaojing Liu, Anirban K. Mitra, Ernst Lengyel, and Jason W. Locasale. “Abstract POSTER-TECH-1123: Advancing metformin as therapeutic for ovarian cancer: metabolomic profiling of mouse ovarian tumors identifies metformin-induced global metabolic changes.” In Clinical Cancer Research, Vol. 21. American Association for Cancer Research (AACR), 2015. https://doi.org/10.1158/1557-3265.ovcasymp14-poster-tech-1123.Full Text
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Campbell, Sharon L., Rachael Baker, Steven Lewis, Atsuo Sasaki, Emily M. Wilkerson, Jason Locasale, Lewis C. Cantley, Brian Kuhlman, and Henrik Dohlman. “Ras Activity Regulation by Monoubiquitination.” In Faseb Journal, Vol. 27. FEDERATION AMER SOC EXP BIOL, 2013.Link to Item
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Shestov, Alexander, Anthony Mancuso, Jason W. Locasale, and Jerry D. Glickson. “Human melanoma metabolic network analysis with combined 13C NMR/bioreactor technique: testing the Warburg effect.” In Faseb Journal, Vol. 27. FEDERATION AMER SOC EXP BIOL, 2013.Link to Item
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Locasale, Jason W., Arup K. Chakraborty, and Andrey Shaw. “Scaffold proteins confer diverse regulatory properties to protein kinase cascades.” In Faseb Journal, 21:A264–A264. FEDERATION AMER SOC EXP BIOL, 2007.Link to Item
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Castner, E. W., B. J. Lee, E. G. Diken, H. Shirota, M. DeRitter, P. P. Wiewior, and J. W. Locasale. “Friction, dynamics, and length scales in hydrophilic polymers.” In Abstracts of Papers of the American Chemical Society, 225:U446–U446. AMER CHEMICAL SOC, 2003.Link to Item
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Preprints
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Allen, Annamarie E., Yudong Sun, Fangchao Wei, Michael A. Reid, and Jason W. Locasale. “Nucleotide metabolism is linked to cysteine availability.” Cold Spring Harbor Laboratory, October 1, 2022. https://doi.org/10.1101/2022.09.30.510321.Full Text
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- Teaching & Mentoring
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Recent Courses
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