Jason Andrew Somarelli

Preprint · 2023 Chondrosarcoma (CSA) is the second most common primary malignancy of bone, whose aggressive potential and chemo-resistant nature result in extremely poor outcomes in patients with advanced disease. Grading and prognostication of these tumors remain a signi ... Full text Cite

Loss of the chromatin remodeler, ATRX, promotes aggressive features of osteosarcoma with increased NF-κB signaling and integrin receptor binding

Preprint · 2022 Full text Cite

Emergent dynamics of underlying regulatory network links EMT and androgen receptor-dependent resistance in prostate cancer

Preprint · 2022 Advanced prostate cancer patients initially respond to hormone therapy, be it in the form of androgen deprivation therapy or second-generation hormone therapies, such as abiraterone acetate or enzalutamide. However, most men with prostate cancer eventually ... Full text Cite

A synthetic lethal screen for Snail-induced enzalutamide resistance identifies JAK/STAT signaling as a therapeutic vulnerability in prostate cancer

Preprint · 2022 Full text Cite

Convergent evolution of p38/MAPK activation in hormone resistant prostate cancer mediates pro-survival, immune evasive, and metastatic phenotypes

Preprint · 2020 Full text Cite

Development of a precision medicine pipeline to identify personalized treatments for colorectal cancer

Preprint · 2020 Full text Cite

Impact of limb salvage versus amputation on overall survival in patients with osteosarcoma of the extremities: an update in the modern era using the National Cancer Database

Preprint · 2020 Full text Cite

From the clinic to the bench and back again in one dog year: identifying new treatments for sarcoma using a cross-species personalized medicine pipeline

Preprint · 2019 Full text Cite

An integrative systems biology and experimental approach identifies convergence of epithelial plasticity, metabolism, and autophagy to promote chemoresistance

Preprint · 2018 Full text Cite

Jason Andrew Somarelli

Scholarly Works - Preprints

Multi-modal transcriptomic analysis unravels enrichment of hybrid epithelial/mesenchymal state and enhanced phenotypic heterogeneity in basal breast cancer

Dynamical modelling of proliferative-invasive plasticity and IFNγ signaling in melanoma reveals mechanisms of PD-L1 expression heterogeneity

Mutually exclusive teams-like patterns of gene regulation characterize phenotypic heterogeneity along the noradrenergic-mesenchymal axis in neuroblastoma

Toxicogenomic analysis of the carcinogenic potential of plastic additives

LCP1 Regulates Cell Motility in Chondrosarcoma and Correlates with Metastatic Potential and Poor Patient Outcomes

Loss of the chromatin remodeler, ATRX, promotes aggressive features of osteosarcoma with increased NF-κB signaling and integrin receptor binding

Emergent dynamics of underlying regulatory network links EMT and androgen receptor-dependent resistance in prostate cancer

A synthetic lethal screen for Snail-induced enzalutamide resistance identifies JAK/STAT signaling as a therapeutic vulnerability in prostate cancer

Partial EMT and associated changes in cellular plasticity in oncovirus-positive samples

The ELF3 transcription factor is associated with an epithelial phenotype and represses epithelial-mesenchymal transition

Mapping phenotypic heterogeneity in melanoma onto the epithelial-hybrid-mesenchymal axis

Analysis of immune subtypes across the epithelial-mesenchymal plasticity spectrum

KLF4 induces Mesenchymal - Epithelial Transition (MET) by suppressing multiple EMT-inducing transcription factors

Atrx deletion impairs cGAS-STING signaling and increases response to radiation and oncolytic herpesvirus in sarcoma

A cross-species drug discovery pipeline to identify and validate new treatments for osteosarcoma

Convergent evolution of p38/MAPK activation in hormone resistant prostate cancer mediates pro-survival, immune evasive, and metastatic phenotypes

Development of a precision medicine pipeline to identify personalized treatments for colorectal cancer

Impact of limb salvage versus amputation on overall survival in patients with osteosarcoma of the extremities: an update in the modern era using the National Cancer Database

From the clinic to the bench and back again in one dog year: identifying new treatments for sarcoma using a cross-species personalized medicine pipeline

An integrative systems biology and experimental approach identifies convergence of epithelial plasticity, metabolism, and autophagy to promote chemoresistance

E-cadherin represses anchorage-independent growth in sarcomas through both signaling and mechanical mechanisms

Epithelial-mesenchymal plasticity: How have quantitative mathematical models helped improve our understanding?

EMT and MET: necessary or permissive for metastasis?