Jay Alan Baker
Professor of Radiology
As a radiologist in the Division of Breast Imaging, I am interested in studying techniques to better detect and assess breast lesions that may represent breast cancer. The major focus of my research activity involves identifying features of breast lesions on mammography/tomosynthesis, ultrasound and MRI that reliably indicate breast cancer or, equally important, reliably indicate a lesion is not breast cancer and biopsy can be safely avoided.
Breast cancer is the most common malignancy occurring in women and the second most frequent cause of non-skin cancer deaths among women. Screening mammography programs have repeatedly shown a reduction in the mortality from breast cancer by 30 to 50%. However, breast imaging suffers from a lack of specificity. The result is that 60 to 80% of breast biopsies performed in this country are for benign lesions and are therefore - in retrospect - unnecessary. Because of the overlap in imaging features of benign and malignant lesions, however, these lesions cannot be differentiated without tissue sampling, and the extraordinary number of breast biopsies performed markedly increases the cost of breast cancer prevention programs and is an impediment to breast screening for some women. To overcome this limitation, we are working to identify previously unrecognized features of breast lesions. Some of these features appear to confirm that a lesion is definitively benign without the need for biopsy. Other features have identified a particular appearance for breast cancer with features that mimic other benign lesions, thus allowing earlier diagnosis and fewer overlooked breast cancers. We are assessing these features with large reader studies to both determine the accuracy and to confirm that the features can be taught and recognized by radiologists at all levels of breast imaging experience. If successful, widespread adoption and recognition of these features may greatly reduce the number of women who undergo a needle biopsy for a benign breast lesion. Conversely, widespread recognition of other features may reduce delays in diagnosis of breast cancer.
Breast cancer is the most common malignancy occurring in women and the second most frequent cause of non-skin cancer deaths among women. Screening mammography programs have repeatedly shown a reduction in the mortality from breast cancer by 30 to 50%. However, breast imaging suffers from a lack of specificity. The result is that 60 to 80% of breast biopsies performed in this country are for benign lesions and are therefore - in retrospect - unnecessary. Because of the overlap in imaging features of benign and malignant lesions, however, these lesions cannot be differentiated without tissue sampling, and the extraordinary number of breast biopsies performed markedly increases the cost of breast cancer prevention programs and is an impediment to breast screening for some women. To overcome this limitation, we are working to identify previously unrecognized features of breast lesions. Some of these features appear to confirm that a lesion is definitively benign without the need for biopsy. Other features have identified a particular appearance for breast cancer with features that mimic other benign lesions, thus allowing earlier diagnosis and fewer overlooked breast cancers. We are assessing these features with large reader studies to both determine the accuracy and to confirm that the features can be taught and recognized by radiologists at all levels of breast imaging experience. If successful, widespread adoption and recognition of these features may greatly reduce the number of women who undergo a needle biopsy for a benign breast lesion. Conversely, widespread recognition of other features may reduce delays in diagnosis of breast cancer.
Current Appointments & Affiliations
- Professor of Radiology, Radiology, Breast Imaging, Radiology 2013
- Chief, Breast Imaging, Radiology, Breast Imaging, Radiology 2003
- Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2000
Contact Information
- Box 3808 Med Ctr, Durham, NC 27710
- Dept of Radiology, Durham, NC 27710
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jay.baker@duke.edu
(919) 684-7655
- Background
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Education, Training, & Certifications
- Resident, Radiology, Duke University 1992 - 1997
- M.D., Duke University 1992
- B.A., University of Pennsylvania 1988
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Duke Appointment History
- Associate Professor of Radiology, Radiology, Breast Imaging, Radiology 2008 - 2013
- Associate Professor of Radiology, Radiology, Breast Imaging, Radiology 2005 - 2008
- Assistant Professor of Radiology, Radiology, Breast Imaging, Radiology 2000 - 2004
- Clinical Associate in the Department of Radiology, Radiology, Breast Imaging, Radiology 1997 - 1998
- Instructor, Temporary in the Department of Radiology, Radiology, Breast Imaging, Radiology 1997
- Research
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Selected Grants
- Genomic Diversity and the Microenvironment as Drivers of Progression in DCIS awarded by Department of Defense 2014 - 2021
- Machine learning and collaborative filtering tools for personalized education in digital breast tomosynthesis awarded by National Institutes of Health 2016 - 2021
- Preoperative Breast Radiotherapy: A Tool to Provide Individualized and Biologically-Based Radiation Therapy awarded by Gateway for Cancer Research 2015 - 2021
- (PQC3) Genomic Diversity and the Microenvironment as Drivers of Metastasis in DCIS awarded by National Institutes of Health 2014 - 2019
- Improved education in digital breast tomosynthesis using machine learning and computer vision tools awarded by Radiological Society of North America 2014 - 2016
- Combined breast MRI/biomarker strategies to identify aggressive biology awarded by National Institutes of Health 2015
- Tension-Stat3-miR-mediated metastasis awarded by University of California - San Francisco 2015
- (PQA5) 'Dose and Mechanisms of Exercise in Breast Cancer Prevention' awarded by National Institutes of Health 2013 - 2014
- 3D Digital Breast Phantoms For Multimodality Research awarded by National Institutes of Health 2010 - 2014
- Information-Theoretic Based CAD in Mammography awarded by National Institutes of Health 2003 - 2011
- Tomosynthesis for Improved Breast Cancer Detection awarded by National Institutes of Health 2006 - 2011
- Reducing Benign Breast Biopsies with Computer Modeling awarded by National Institutes of Health 2003 - 2008
- FDG-PEM Detection - Characterization of Breast Cancer awarded by National Institutes of Health 2004 - 2007
- Breast Elemental Composition Imaging awarded by National Institutes of Health 2004 - 2007
- Resolution Requirements for Mammographic Displays awarded by National Institutes of Health 2003 - 2006
- Predicting Breast Cancer With Ultrasound and Mammography awarded by National Institutes of Health 2002 - 2005
- Improved Diagnosis of Breast Microcalcification Clusters awarded by National Institutes of Health 2001 - 2004
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External Relationships
- Gerson Lehrman Group
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Bahl, Manisha, Jay A. Baker, Emily N. Kinsey, and Sujata V. Ghate. “MRI predictors of tumor-positive margins after breast-conserving surgery.” Clin Imaging 57 (September 2019): 45–49. https://doi.org/10.1016/j.clinimag.2019.05.006.Full Text Link to Item
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Hendrick, R Edward, Jay A. Baker, and Mark A. Helvie. “Breast cancer deaths averted over 3 decades.” Cancer 125, no. 9 (May 1, 2019): 1482–88. https://doi.org/10.1002/cncr.31954.Full Text Link to Item
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Georgian-Smith, Dianne, Nancy A. Obuchowski, Joseph Y. Lo, Rachel F. Brem, Jay A. Baker, Paul R. Fisher, Alice Rim, Wei Zhao, Laurie L. Fajardo, and Thomas Mertelmeier. “Can Digital Breast Tomosynthesis Replace Full-Field Digital Mammography? A Multireader, Multicase Study of Wide-Angle Tomosynthesis.” Ajr Am J Roentgenol, April 1, 2019, 1–7. https://doi.org/10.2214/AJR.18.20294.Full Text Link to Item
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Natarajan, Brahma, Daphna Spiegel, Elizabeth M. Nichols, Steven Feigenberg, Rachel Blitzblau, Gloria Broadwater, Eileen A. Duffy, Jay A. Baker, and Janet K. Horton. “Findings on Surveillance Imaging After Preoperative Partial Breast Irradiation for Early Stage Breast Cancer.” Int J Radiat Oncol Biol Phys 102, no. 4 (November 15, 2018): 1374–81. https://doi.org/10.1016/j.ijrobp.2018.05.059.Full Text Link to Item
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Baker, Jay A. “Accurate Inputs for Costs and Benefits of Screening Mammography.” Ajr Am J Roentgenol 211, no. 1 (July 2018): W80. https://doi.org/10.2214/AJR.18.19650.Full Text Link to Item
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Shi, Bibo, Lars J. Grimm, Maciej A. Mazurowski, Jay A. Baker, Jeffrey R. Marks, Lorraine M. King, Carlo C. Maley, E Shelley Hwang, and Joseph Y. Lo. “Prediction of Occult Invasive Disease in Ductal Carcinoma in Situ Using Deep Learning Features.” J Am Coll Radiol 15, no. 3 Pt B (March 2018): 527–34. https://doi.org/10.1016/j.jacr.2017.11.036.Full Text Link to Item
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Baker, Jay A. “False Information About Breast Cancer Screening.” Jama Intern Med 178, no. 2 (February 1, 2018): 298–99. https://doi.org/10.1001/jamainternmed.2017.7084.Full Text Link to Item
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Grimm, Lars J., Jing Zhang, Jay A. Baker, Mary S. Soo, Karen S. Johnson, and Maciej A. Mazurowski. “Relationships Between MRI Breast Imaging-Reporting and Data System (BI-RADS) Lexicon Descriptors and Breast Cancer Molecular Subtypes: Internal Enhancement is Associated with Luminal B Subtype.” Breast J 23, no. 5 (September 2017): 579–82. https://doi.org/10.1111/tbj.12799.Full Text Link to Item
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Shi, Bibo, Lars J. Grimm, Maciej A. Mazurowski, Jay A. Baker, Jeffrey R. Marks, Lorraine M. King, Carlo C. Maley, E Shelley Hwang, and Joseph Y. Lo. “Can Occult Invasive Disease in Ductal Carcinoma In Situ Be Predicted Using Computer-extracted Mammographic Features?” Acad Radiol 24, no. 9 (September 2017): 1139–47. https://doi.org/10.1016/j.acra.2017.03.013.Full Text Link to Item
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Vasan, Alison, Jay A. Baker, Rebecca A. Shelby, and Mary Scott C. Soo. “Impact of Sodium Bicarbonate-Buffered Lidocaine on Patient Pain During Image-Guided Breast Biopsy.” J Am Coll Radiol 14, no. 9 (September 2017): 1194–1201. https://doi.org/10.1016/j.jacr.2017.03.026.Full Text Link to Item
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Grimm, Lars J., David Y. Johnson, Karen S. Johnson, Jay A. Baker, Mary Scott Soo, E Shelley Hwang, and Sujata V. Ghate. “Suspicious breast calcifications undergoing stereotactic biopsy in women ages 70 and over: Breast cancer incidence by BI-RADS descriptors.” Eur Radiol 27, no. 6 (June 2017): 2275–81. https://doi.org/10.1007/s00330-016-4617-7.Full Text Link to Item
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Hayes Balmadrid, Melissa A., Rebecca A. Shelby, Anava A. Wren, Lauren S. Miller, Sora C. Yoon, Jay A. Baker, Liz A. Wildermann, and Mary Scott Soo. “Anxiety prior to breast biopsy: Relationships with length of time from breast biopsy recommendation to biopsy procedure and psychosocial factors.” J Health Psychol 22, no. 5 (April 2017): 561–71. https://doi.org/10.1177/1359105315607828.Full Text Link to Item
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Miller, Lauren S., Rebecca A. Shelby, Melissa Hayes Balmadrid, Sora Yoon, Jay A. Baker, Liz Wildermann, and Mary Scott Soo. “Patient Anxiety Before and Immediately After Imaging-Guided Breast Biopsy Procedures: Impact of Radiologist-Patient Communication.” J Am Coll Radiol 13, no. 11S (November 2016): e62–71. https://doi.org/10.1016/j.jacr.2016.09.034.Full Text Link to Item
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Bahl, Manisha, Jay A. Baker, Mythreyi Bhargavan-Chatfield, Eugenia K. Brandt, and Sujata V. Ghate. “Impact of Breast Density Notification Legislation on Radiologists' Practices of Reporting Breast Density: A Multi-State Study.” Radiology 280, no. 3 (September 2016): 701–6. https://doi.org/10.1148/radiol.2016152457.Full Text Link to Item
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Nelson, Jeffrey S., Jered R. Wells, Jay A. Baker, and Ehsan Samei. “How does c-view image quality compare with conventional 2D FFDM?” Med Phys 43, no. 5 (May 2016): 2538. https://doi.org/10.1118/1.4947293.Full Text Link to Item
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Bahl, Manisha, Jay A. Baker, and Sujata V. Ghate. “Reply to "Conventional Ductography Combined With Digital Breast Tomosynthesis for Imaging of Pathologic Nipple Discharge".” Ajr Am J Roentgenol 206, no. 2 (February 2016): W45. https://doi.org/10.2214/AJR.15.15606.Full Text Link to Item
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Baker, Jay A. “In Estimating Overdiagnosis, Details Matter.” Acad Radiol 23, no. 1 (January 2016): 115–16. https://doi.org/10.1016/j.acra.2015.08.034.Full Text Link to Item
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Bahl, Manisha, Jay A. Baker, Emily N. Kinsey, and Sujata V. Ghate. “Architectural Distortion on Mammography: Correlation With Pathologic Outcomes and Predictors of Malignancy.” Ajr Am J Roentgenol 205, no. 6 (December 2015): 1339–45. https://doi.org/10.2214/AJR.15.14628.Full Text Link to Item
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Bahl, Manisha, Jay A. Baker, Rachel A. Greenup, and Sujata V. Ghate. “Evaluation of Pathologic Nipple Discharge: What is the Added Diagnostic Value of MRI?” Ann Surg Oncol 22 Suppl 3 (December 2015): S435–41. https://doi.org/10.1245/s10434-015-4792-9.Full Text Link to Item
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Blitzblau, Rachel C., Ritu Arya, Sua Yoo, Jay A. Baker, Zheng Chang, Manisha Palta, Eileen Duffy, and Janet K. Horton. “A phase 1 trial of preoperative partial breast radiation therapy: Patient selection, target delineation, and dose delivery.” Pract Radiat Oncol 5, no. 5 (September 2015): e513–20. https://doi.org/10.1016/j.prro.2015.02.002.Full Text Link to Item
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Grimm, Lars J., Andy L. Anderson, Jay A. Baker, Karen S. Johnson, Ruth Walsh, Sora C. Yoon, and Sujata V. Ghate. “Frequency of Malignancy and Imaging Characteristics of Probably Benign Lesions Seen at Breast MRI.” Ajr Am J Roentgenol 205, no. 2 (August 2015): 442–47. https://doi.org/10.2214/AJR.14.13530.Full Text Link to Item
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Horton, Janet K., Rachel C. Blitzblau, Sua Yoo, Joseph Geradts, Zheng Chang, Jay A. Baker, Gregory S. Georgiade, et al. “Preoperative Single-Fraction Partial Breast Radiation Therapy: A Novel Phase 1, Dose-Escalation Protocol With Radiation Response Biomarkers.” Int J Radiat Oncol Biol Phys 92, no. 4 (July 15, 2015): 846–55. https://doi.org/10.1016/j.ijrobp.2015.03.007.Full Text Link to Item
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Bahl, Manisha, Jay A. Baker, Rachel A. Greenup, and Sujata V. Ghate. “Diagnostic Value of Ultrasound in Female Patients With Nipple Discharge.” Ajr Am J Roentgenol 205, no. 1 (July 2015): 203–8. https://doi.org/10.2214/AJR.14.13354.Full Text Link to Item
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Grimm, Lars J., Andy L. Anderson, Jay A. Baker, Karen S. Johnson, Ruth Walsh, Sora C. Yoon, and Sujata V. Ghate. “Interobserver Variability Between Breast Imagers Using the Fifth Edition of the BI-RADS MRI Lexicon.” Ajr Am J Roentgenol 204, no. 5 (May 2015): 1120–24. https://doi.org/10.2214/AJR.14.13047.Full Text Link to Item
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Grimm, Lars J., Karen S. Johnson, P Kelly Marcom, Jay A. Baker, and Mary S. Soo. “Can breast cancer molecular subtype help to select patients for preoperative MR imaging?” Radiology 274, no. 2 (February 2015): 352–58. https://doi.org/10.1148/radiol.14140594.Full Text Link to Item
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Miller, Lauren S., Rebecca A. Shelby, Melissa Hayes Balmadrid, Sora Yoon, Jay A. Baker, Liz Wildermann, and Mary Scott Soo. “Patient anxiety before and immediately after imaging-guided breast biopsy procedures: impact of radiologist-patient communication.” J Am Coll Radiol 10, no. 6 (June 2013): 423–31. https://doi.org/10.1016/j.jacr.2012.11.005.Full Text Link to Item
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Johnson, Karen S., Jay A. Baker, Sheila S. Lee, and Mary Scott Soo. “Cancelation of MRI guided breast biopsies for suspicious breast lesions identified at 3.0 T MRI: reasons, rates, and outcomes.” Acad Radiol 20, no. 5 (May 2013): 569–75. https://doi.org/10.1016/j.acra.2013.01.005.Full Text Link to Item
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Lyman, Gary H., Jay Baker, Joseph Geradts, Janet Horton, Gretchen Kimmick, Jeffrey Peppercorn, Scott Pruitt, Randall P. Scheri, and E Shelley Hwang. “Multidisciplinary care of patients with early-stage breast cancer.” Surg Oncol Clin N Am 22, no. 2 (April 2013): 299–317. https://doi.org/10.1016/j.soc.2012.12.005.Full Text Link to Item
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Johnson, Karen S., Rex C. Bentley, P. Kelly Marcom, and Jay A. Baker. “Pseudoangiomatous stromal hyperplasia (PASH) causing massive breast enlargement: MRI findings.” Breast J 18, no. 6 (November 2012): 600–601. https://doi.org/10.1111/tbj.12026.Full Text Link to Item
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Mazurowski, Maciej A., Huiman X. Barnhart, Jay A. Baker, and Georgia D. Tourassi. “Identifying error-making patterns in assessment of mammographic BI-RADS descriptors among radiology residents using statistical pattern recognition.” Acad Radiol 19, no. 7 (July 2012): 865–71. https://doi.org/10.1016/j.acra.2012.01.012.Full Text Link to Item
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Johnson, Karen S., Jay A. Baker, Sheila S. Lee, and Mary S. Soo. “Suspicious breast lesions detected at 3.0 T magnetic resonance imaging: clinical and histological outcomes.” Acad Radiol 19, no. 6 (June 2012): 667–74. https://doi.org/10.1016/j.acra.2012.02.016.Full Text Link to Item
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Ghate, Sujata V., Jay A. Baker, Connie E. Kim, Karen S. Johnson, Ruth Walsh, and Mary Scott C. Soo. “Using the BI-RADS lexicon in a restrictive form of double reading as a strategy for minimizing screening mammography recall rates.” Ajr Am J Roentgenol 198, no. 4 (April 2012): 962–70. https://doi.org/10.2214/AJR.11.6648.Full Text Link to Item
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Baker, Jay A., and Joseph Y. Lo. “Breast tomosynthesis: state-of-the-art and review of the literature.” Acad Radiol 18, no. 10 (October 2011): 1298–1310. https://doi.org/10.1016/j.acra.2011.06.011.Full Text Link to Item
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Brown, Kelan J., Mustafa R. Bashir, Jay A. Baker, Douglas S. Tyler, and Erik K. Paulson. “Imaging-guided preoperative hookwire localization of nonpalpable extramammary lesions.” Ajr Am J Roentgenol 197, no. 3 (September 2011): W525–27. https://doi.org/10.2214/AJR.10.6176.Full Text Link to Item
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Ghate, Sujata V., Jay A. Baker, Ashley D. Hawkins, and Brian J. Soher. “Titanium vs carbon coated ceramic breast tissue marker clips: 3T MR susceptibility artifact and local signal disturbance.” Acad Radiol 18, no. 6 (June 2011): 770–73. https://doi.org/10.1016/j.acra.2011.01.008.Full Text Link to Item
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Webb, Lincoln J., Ehsan Samei, Joseph Y. Lo, Jay A. Baker, Sujata V. Ghate, Connie Kim, Mary Scott Soo, and Ruth Walsh. “Comparative performance of multiview stereoscopic and mammographic display modalities for breast lesion detection.” Med Phys 38, no. 4 (April 2011): 1972–80. https://doi.org/10.1118/1.3562901.Full Text Link to Item
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Singh, Swatee, Jeff Maxwell, Jay A. Baker, Jennifer L. Nicholas, and Joseph Y. Lo. “Computer-aided classification of breast masses: performance and interobserver variability of expert radiologists versus residents.” Radiology 258, no. 1 (January 2011): 73–80. https://doi.org/10.1148/radiol.10081308.Full Text Link to Item
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Liang, K., E. D. Light, J. A. Baker, F. Lachmann, J. Collins, and S. W. Smith. “Clinical prototype of autonomous breast biopsy robot guided by 4Dultrasound.” Proceedings Ieee Ultrasonics Symposium, December 1, 2010, 2348–51. https://doi.org/10.1109/ULTSYM.2010.5935778.Full Text
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Bennett, Lisa E., Sujata V. Ghate, Rex Bentley, and Jay A. Baker. “Is surgical excision of core biopsy proven benign papillomas of the breast necessary?” Acad Radiol 17, no. 5 (May 2010): 553–57. https://doi.org/10.1016/j.acra.2010.01.001.Full Text Link to Item
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Mazurowski, Maciej A., Jay A. Baker, Huiman X. Barnhart, and Georgia D. Tourassi. “Individualized computer-aided education in mammography based on user modeling: concept and preliminary experiments.” Med Phys 37, no. 3 (March 2010): 1152–60. https://doi.org/10.1118/1.3301575.Full Text Link to Item
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Bukhman, Rita, Randall P. Scheri, Maria Angelica Selim, and Jay A. Baker. “Sonography in the identification of calciphylaxis of the breast.” J Ultrasound Med 29, no. 1 (January 2010): 129–33. https://doi.org/10.7863/jum.2010.29.1.129.Full Text Link to Item
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Tebbit, Christopher L., Jun Zhai, Brian R. Untch, Matthew J. Ellis, Holly K. Dressman, Rex C. Bentley, Jay A. Baker, et al. “Novel tumor sampling strategies to enable microarray gene expression signatures in breast cancer: a study to determine feasibility and reproducibility in the context of clinical care.” Breast Cancer Res Treat 118, no. 3 (December 2009): 635–43. https://doi.org/10.1007/s10549-008-0301-1.Full Text Link to Item
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Chawla, Amarpreet S., Joseph Y. Lo, Jay A. Baker, and Ehsan Samei. “Optimized image acquisition for breast tomosynthesis in projection and reconstruction space.” Med Phys 36, no. 11 (November 2009): 4859–69. https://doi.org/10.1118/1.3231814.Full Text Link to Item
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Wilke, Lee G., Gloria Broadwater, Sarah Rabiner, Elizabeth Owens, Sora Yoon, Sujata Ghate, Victoria Scott, et al. “Breast self-examination: defining a cohort still in need.” Am J Surg 198, no. 4 (October 2009): 575–79. https://doi.org/10.1016/j.amjsurg.2009.06.012.Full Text Link to Item
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Saunders, Robert S., Ehsan Samei, Joseph Y. Lo, and Jay A. Baker. “Can compression be reduced for breast tomosynthesis? Monte carlo study on mass and microcalcification conspicuity in tomosynthesis.” Radiology 251, no. 3 (June 2009): 673–82. https://doi.org/10.1148/radiol.2521081278.Full Text Link to Item
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Pollard, Benjamin J., Ehsan Samei, Amarpreet S. Chawla, Jay Baker, Sujata Ghate, Connie Kim, Mary S. Soo, and Noriyuki Hashimoto. “The influence of increased ambient lighting on mass detection in mammograms.” Acad Radiol 16, no. 3 (March 2009): 299–304. https://doi.org/10.1016/j.acra.2008.08.017.Full Text Link to Item
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Singh, Swatee, Georgia D. Tourassi, Jay A. Baker, Ehsan Samei, and Joseph Y. Lo. “Automated breast mass detection in 3D reconstructed tomosynthesis volumes: a featureless approach.” Med Phys 35, no. 8 (August 2008): 3626–36. https://doi.org/10.1118/1.2953562.Full Text Link to Item
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Chawla, Amarpreet S., Ehsan Samei, Robert S. Saunders, Joseph Y. Lo, and Jay A. Baker. “A mathematical model platform for optimizing a multiprojection breast imaging system.” Med Phys 35, no. 4 (April 2008): 1337–45. https://doi.org/10.1118/1.2885367.Full Text Link to Item
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Mazurowski, Maciej A., Piotr A. Habas, Jacek M. Zurada, Joseph Y. Lo, Jay A. Baker, and Georgia D. Tourassi. “Training neural network classifiers for medical decision making: the effects of imbalanced datasets on classification performance.” Neural Netw 21, no. 2–3 (March 2008): 427–36. https://doi.org/10.1016/j.neunet.2007.12.031.Full Text Link to Item
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Baker, J. A. “4-13 Effect of Computer-Aided Detection on Independent Double Reading of Paired Screen-Film and Full-Field Digital Screening Mammograms.” Breast Diseases 18, no. 4 (January 1, 2008): 357. https://doi.org/10.1016/S1043-321X(07)80394-8.Full Text
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Saunders, Robert S., Jay A. Baker, David M. Delong, Jeff P. Johnson, and Ehsan Samei. “Does image quality matter? Impact of resolution and noise on mammographic task performance.” Med Phys 34, no. 10 (October 2007): 3971–81. https://doi.org/10.1118/1.2776253.Full Text Link to Item
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Jesneck, Jonathan L., Joseph Y. Lo, and Jay A. Baker. “Breast mass lesions: computer-aided diagnosis models with mammographic and sonographic descriptors.” Radiology 244, no. 2 (August 2007): 390–98. https://doi.org/10.1148/radiol.2442060712.Full Text Link to Item
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Ghate, S. V., C. Kim, K. Johnson, J. A. Baker, and M. C. Soo. “Minimal Screening Mammography Recall Rates Using Standardized BI-RADS Criteria.” American Journal of Roentgenology 188, no. 5 (May 1, 2007).Link to Item
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Samei, Ehsan, Robert S. Saunders, Jay A. Baker, and David M. Delong. “Digital mammography: effects of reduced radiation dose on diagnostic performance.” Radiology 243, no. 2 (May 2007): 396–404. https://doi.org/10.1148/radiol.2432061065.Full Text Link to Item
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Saunders, Robert S., Ehsan Samei, Jay Baker, David Delong, Mary Scott Soo, Ruth Walsh, Etta Pisano, Cherie M. Kuzmiak, and Dag Pavic. “Comparison of LCD and CRT displays based on efficacy for digital mammography.” Acad Radiol 13, no. 11 (November 2006): 1317–26. https://doi.org/10.1016/j.acra.2006.07.017.Full Text Link to Item
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Jesneck, Jonathan L., Loren W. Nolte, Jay A. Baker, Carey E. Floyd, and Joseph Y. Lo. “Optimized approach to decision fusion of heterogeneous data for breast cancer diagnosis.” Med Phys 33, no. 8 (August 2006): 2945–54. https://doi.org/10.1118/1.2208934.Full Text Link to Item
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Saunders, Robert, Ehsan Samei, Jay Baker, and David Delong. “Simulation of mammographic lesions.” Acad Radiol 13, no. 7 (July 2006): 860–70. https://doi.org/10.1016/j.acra.2006.03.015.Full Text Link to Item
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Chen, Y., J. Y. Lo, J. A. Baker, and J. T. Dobbins. “Gaussian frequency blending algorithm with Matrix Inversion Tomosynthesis (MITS) and Filtered Back Projection (FBP) for better digital breast tomosynthesis reconstruction.” Progress in Biomedical Optics and Imaging Proceedings of Spie 6142 I (June 30, 2006). https://doi.org/10.1117/12.652264.Full Text
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Jesneck, J. L., L. W. Nolte, J. A. Baker, and J. Y. Lo. “The effect of data set size on computer-aided diagnosis of breast cancer: Comparing decision fusion to a linear discriminant.” Progress in Biomedical Optics and Imaging Proceedings of Spie 6146 (June 23, 2006). https://doi.org/10.1117/12.655235.Full Text
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Ghate, Sujata V., Eric L. Rosen, Mary Scott C. Soo, and Jay A. Baker. “MRI-guided vacuum-assisted breast biopsy with a handheld portable biopsy system.” Ajr Am J Roentgenol 186, no. 6 (June 2006): 1733–36. https://doi.org/10.2214/AJR.05.0551.Full Text Link to Item
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Soo, Mary Scott, Sujata V. Ghate, Jay A. Baker, Eric L. Rosen, Ruth Walsh, Brenda N. Warwick, A. R. Ramachandran, and Kathryn R. Nightingale. “Streaming detection for evaluation of indeterminate sonographic breast masses: a pilot study.” Ajr Am J Roentgenol 186, no. 5 (May 2006): 1335–41. https://doi.org/10.2214/AJR.05.0005.Full Text Link to Item
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Soo, M. S., S. Ghate, J. A. Baker, and E. Rosen. “Reply [2].” American Journal of Roentgenology 186, no. 3 (March 1, 2006): 902–3. https://doi.org/10.2214/AJR.06.5013-1.Full Text
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Saunders, R. S., E. Samei, J. Johnson, and J. Baker. “Effect of display resolution on the detection of mammographie lesions.” Progress in Biomedical Optics and Imaging Proceedings of Spie 5749 (September 19, 2005): 243–50. https://doi.org/10.1117/12.595682.Full Text
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Bilska-Wolak, Anna O., Carey E. Floyd, Joseph Y. Lo, and Jay A. Baker. “Computer aid for decision to biopsy breast masses on mammography: validation on new cases.” Acad Radiol 12, no. 6 (June 2005): 671–80. https://doi.org/10.1016/j.acra.2005.02.011.Full Text Link to Item
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Baker, Jay A., Eric L. Rosen, Michele M. Crockett, and Joseph Y. Lo. “Accuracy of segmentation of a commercial computer-aided detection system for mammography.” Radiology 235, no. 2 (May 2005): 385–90. https://doi.org/10.1148/radiol.2352040899.Full Text Link to Item
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Cole, Elodia B., Etta D. Pisano, Donglin Zeng, Keith Muller, Stephen R. Aylward, Sungwook Park, Cherie Kuzmiak, et al. “The effects of gray scale image processing on digital mammography interpretation performance.” Acad Radiol 12, no. 5 (May 2005): 585–95. https://doi.org/10.1016/j.acra.2005.01.017.Full Text Link to Item
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Ghate, Sujata V., Mary Scott Soo, Jay A. Baker, Ruth Walsh, Edgardo I. Gimenez, and Eric L. Rosen. “Comparison of recall and cancer detection rates for immediate versus batch interpretation of screening mammograms.” Radiology 235, no. 1 (April 2005): 31–35. https://doi.org/10.1148/radiol.2351040699.Full Text Link to Item
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Hong, Andrea S., Eric L. Rosen, Mary S. Soo, and Jay A. Baker. “BI-RADS for sonography: positive and negative predictive values of sonographic features.” Ajr Am J Roentgenol 184, no. 4 (April 2005): 1260–65. https://doi.org/10.2214/ajr.184.4.01841260.Full Text Link to Item
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Soo, Mary Scott, Eric L. Rosen, Jessie Q. Xia, Sujata Ghate, and Jay A. Baker. “Computer-aided detection of amorphous calcifications.” Ajr Am J Roentgenol 184, no. 3 (March 2005): 887–92. https://doi.org/10.2214/ajr.184.3.01840887.Full Text Link to Item
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Rosen, Eric L., Timothy G. Turkington, Mary Scott Soo, Jay A. Baker, and R Edward Coleman. “Detection of primary breast carcinoma with a dedicated, large-field-of-view FDG PET mammography device: initial experience.” Radiology 234, no. 2 (February 2005): 527–34. https://doi.org/10.1148/radiol.2342040654.Full Text Link to Item
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Baker, Jay A., Joseph Y. Lo, David M. Delong, and Carey E. Floyd. “Computer-aided detection in screening mammography: variability in cues.” Radiology 233, no. 2 (November 2004): 411–17. https://doi.org/10.1148/radiol.2332031200.Full Text Link to Item
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Rosen, E. L., K. L. Blackwell, J. A. Baker, and S. G. Orel. “Accuracy of MRI in the detection of residual breast cancer after neoadjuvant chemotherapy.” Breast Diseases 15, no. 2 (July 1, 2004): 140–42.
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Liu, D. L. D., J. A. Baker, and P. Von Behren. “A clinical study of adaptive beamforming using time-delay adjustments on a 1-D array.” Proceedings of the Ieee Ultrasonics Symposium 1 (December 1, 2003): 339–42.
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Rosen, Eric L., Jay A. Baker, and Mary Scott Soo. “Accuracy of a collagen-plug biopsy site marking device deployed after stereotactic core needle breast biopsy.” Ajr Am J Roentgenol 181, no. 5 (November 2003): 1295–99. https://doi.org/10.2214/ajr.181.5.1811295.Full Text Link to Item
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Rosen, Eric L., Kimberly L. Blackwell, Jay A. Baker, Mary Scott Soo, Rex C. Bentley, Daohai Yu, Thaddeus V. Samulski, and Mark W. Dewhirst. “Accuracy of MRI in the detection of residual breast cancer after neoadjuvant chemotherapy.” Ajr Am J Roentgenol 181, no. 5 (November 2003): 1275–82. https://doi.org/10.2214/ajr.181.5.1811275.Full Text Link to Item
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Baker, Jay A., Eric L. Rosen, Joseph Y. Lo, Edgardo I. Gimenez, Ruth Walsh, and Mary Scott Soo. “Computer-aided detection (CAD) in screening mammography: sensitivity of commercial CAD systems for detecting architectural distortion.” Ajr Am J Roentgenol 181, no. 4 (October 2003): 1083–88. https://doi.org/10.2214/ajr.181.4.1811083.Full Text Link to Item
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Soo, Mary Scott, Jay A. Baker, and Eric L. Rosen. “Sonographic detection and sonographically guided biopsy of breast microcalcifications.” Ajr Am J Roentgenol 180, no. 4 (April 2003): 941–48. https://doi.org/10.2214/ajr.180.4.1800941.Full Text Link to Item
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Rosen, Eric L., Rex C. Bentley, Jay A. Baker, and Mary Scott Soo. “Imaging-guided core needle biopsy of papillary lesions of the breast.” Ajr Am J Roentgenol 179, no. 5 (November 2002): 1185–92. https://doi.org/10.2214/ajr.179.5.1791185.Full Text Link to Item
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Hall, Ferris M. “Negative predictive value of breast imaging in patients with palpable lesions.” Ajr Am J Roentgenol 179, no. 4 (October 2002): 1073. https://doi.org/10.2214/ajr.179.4.1791073.Full Text Link to Item
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Pisano, Etta D., Elodia B. Cole, Emily O. Kistner, Keith E. Muller, Bradley M. Hemminger, Mary L. Brown, R Eugene Johnston, et al. “Interpretation of digital mammograms: comparison of speed and accuracy of soft-copy versus printed-film display.” Radiology 223, no. 2 (May 2002): 483–88. https://doi.org/10.1148/radiol.2232010704.Full Text Link to Item
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Baker, Jay A., and Mary Scott Soo. “Breast US: assessment of technical quality and image interpretation.” Radiology 223, no. 1 (April 2002): 229–38. https://doi.org/10.1148/radiol.2231011125.Full Text Link to Item
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Rosen, Eric L., Jay A. Baker, and Mary Scott Soo. “Malignant lesions initially subjected to short-term mammographic follow-up.” Radiology 223, no. 1 (April 2002): 221–28. https://doi.org/10.1148/radiol.2231011355.Full Text Link to Item
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Soo, Mary Scott, Jay A. Baker, Eric L. Rosen, and Thuy T. Vo. “Sonographically guided biopsy of suspicious microcalcifications of the breast: a pilot study.” Ajr Am J Roentgenol 178, no. 4 (April 2002): 1007–15. https://doi.org/10.2214/ajr.178.4.1781007.Full Text Link to Item
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Lo, Joseph Y., Mia K. Markey, Jay A. Baker, and Carey E. Floyd. “Cross-institutional evaluation of BI-RADS predictive model for mammographic diagnosis of breast cancer.” Ajr Am J Roentgenol 178, no. 2 (February 2002): 457–63. https://doi.org/10.2214/ajr.178.2.1780457.Full Text Link to Item
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Soo, M. S., E. L. Rosen, J. A. Baker, T. T. Vo, and B. A. Boyd. “Negative predictive value of sonography with mammography in patients with palpable breast lesions.” Ajr Am J Roentgenol 177, no. 5 (November 2001): 1167–70. https://doi.org/10.2214/ajr.177.5.1771167.Full Text Link to Item
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Baker, J. A., M. S. Soo, and E. L. Rosen. “Artifacts and pitfalls in sonographic imaging of the breast.” Ajr Am J Roentgenol 176, no. 5 (May 2001): 1261–66. https://doi.org/10.2214/ajr.176.5.1761261.Full Text Link to Item
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Baker, J. A., and M. S. Soo. “The evolving role of sonography in evaluating solid breast masses.” Semin Ultrasound Ct Mr 21, no. 4 (August 2000): 286–96. https://doi.org/10.1016/s0887-2171(00)90023-4.Full Text Link to Item
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Baker, J. A., P. J. Kornguth, M. S. Soo, R. Walsh, and P. Mengoni. “Sonography of solid breast lesions: observer variability of lesion description and assessment.” Ajr Am J Roentgenol 172, no. 6 (June 1999): 1621–25. https://doi.org/10.2214/ajr.172.6.10350302.Full Text Link to Item
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Baker, J. A., M. S. Soo, and P. Mengoni. “Sonographically guided percutaneous interventions of the breast using a steerable ultrasound beam.” Ajr Am J Roentgenol 172, no. 1 (January 1999): 157–59. https://doi.org/10.2214/ajr.172.1.9888759.Full Text Link to Item
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Floyd, C. E., J. Y. Lo, and J. A. Baker. “Prediction of breast biopsy outcomes from mammographic findings.” Edited by K. Doi, H. MacMahon, M. L. Giger, and K. R. Hoffmann. Computer Aided Diagnosis in Medical Imaging 1182 (January 1, 1999): 193–200.Link to Item
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Lo, J. Y., J. A. Baker, P. J. Kornguth, and C. E. Floyd. “Effect of patient history data on the prediction of breast cancer from mammographic findings with artificial neural networks.” Acad Radiol 6, no. 1 (January 1999): 10–15. https://doi.org/10.1016/s1076-6332(99)80056-7.Full Text Link to Item
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Freed, K. S., J. Y. Lo, J. A. Baker, C. E. Floyd, V. H. Low, J. T. Seabourn, and R. C. Nelson. “Predictive model for the diagnosis of intraabdominal abscess.” Acad Radiol 5, no. 7 (July 1998): 473–79. https://doi.org/10.1016/s1076-6332(98)80187-6.Full Text Link to Item
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Lo, J. Y., J. A. Baker, P. J. Kornguth, J. D. Iglehart, and C. E. Floyd. “Predicting breast cancer invasion with artificial neural networks on the basis of mammographic features.” Radiology 203, no. 1 (April 1997): 159–63. https://doi.org/10.1148/radiology.203.1.9122385.Full Text Link to Item
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Vittitoe, N. F., J. A. Baker, and C. E. Floyd. “Fractal texture analysis in computer-aided diagnosis of solitary pulmonary nodules.” Acad Radiol 4, no. 2 (February 1997): 96–101. https://doi.org/10.1016/s1076-6332(97)80005-0.Full Text Link to Item
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Floyd, C. E., G. D. Tourassi, and J. A. Baker. “Use of genetic algorithms for computer-aided diagnosis of breast cancers from image features.” Proceedings of Spie the International Society for Optical Engineering 2710 (December 1, 1996): 51–58. https://doi.org/10.1117/12.237973.Full Text
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Lo, J. Y., J. Kim, J. A. Baker, and C. E. Floyd. “Computer-aided diagnosis of mammography using an artificial neural network: Predicting the invasiveness of breast cancers from image features.” Proceedings of Spie the International Society for Optical Engineering 2710 (December 1, 1996): 725–32. https://doi.org/10.1117/12.237977.Full Text
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Baker, J. A., P. J. Kornguth, and C. E. Floyd. “Breast imaging reporting and data system standardized mammography lexicon: observer variability in lesion description.” Ajr Am J Roentgenol 166, no. 4 (April 1996): 773–78. https://doi.org/10.2214/ajr.166.4.8610547.Full Text Link to Item
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Baker, J. A., P. J. Kornguth, J. Y. Lo, and C. E. Floyd. “Artificial neural network: improving the quality of breast biopsy recommendations.” Radiology 198, no. 1 (January 1996): 131–35. https://doi.org/10.1148/radiology.198.1.8539365.Full Text Link to Item
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Floyd, C. E., J. A. Baker, H. G. Chotas, D. M. Delong, and C. E. Ravin. “Selenium-based digital radiography of the chest: radiologists' preference compared with film-screen radiographs.” Ajr Am J Roentgenol 165, no. 6 (December 1995): 1353–58. https://doi.org/10.2214/ajr.165.6.7484562.Full Text Link to Item
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Lo, J. Y., J. A. Baker, P. J. Kornguth, and C. E. Floyd. “Computer-aided diagnosis of breast cancer: artificial neural network approach for optimized merging of mammographic features.” Acad Radiol 2, no. 10 (October 1995): 841–50. https://doi.org/10.1016/s1076-6332(05)80057-1.Full Text Link to Item
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Baker, J. A., P. J. Kornguth, J. Y. Lo, M. E. Williford, and C. E. Floyd. “Breast cancer: prediction with artificial neural network based on BI-RADS standardized lexicon.” Radiology 196, no. 3 (September 1995): 817–22. https://doi.org/10.1148/radiology.196.3.7644649.Full Text Link to Item
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Baker, J. A., and B. A. Carroll. “The sonographic appearance of anomalous circumrenal vein mimicking perirenal fluid collection.” J Ultrasound Med 14, no. 3 (March 1995): 244–46. https://doi.org/10.7863/jum.1995.14.3.244.Full Text Link to Item
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Lo, J. Y., C. E. Floyd, J. A. Baker, and C. E. Ravin. “Scatter compensation in digital chest radiography using the posterior beam stop technique.” Med Phys 21, no. 3 (March 1994): 435–43. https://doi.org/10.1118/1.597388.Full Text Link to Item
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Baker, J. A., C. E. Floyd, J. Y. Lo, and C. E. Ravin. “Observer evaluation of scatter subtraction for digital portable chest radiographs.” Invest Radiol 28, no. 8 (August 1993): 667–70. https://doi.org/10.1097/00004424-199308000-00001.Full Text Link to Item
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Lo, J. Y., C. E. Floyd, J. A. Baker, and C. E. Ravin. “An artificial neural network for estimating scatter exposures in portable chest radiography.” Med Phys 20, no. 4 (July 1993): 965–73. https://doi.org/10.1118/1.596978.Full Text Link to Item
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Berry, J. J., J. M. Hoffman, C. Steenbergen, J. A. Baker, C. Floyd, P. Van Trigt, M. W. Hanson, and R. E. Coleman. “Human pathologic correlation with PET in ischemic and nonischemic cardiomyopathy.” J Nucl Med 34, no. 1 (January 1993): 39–47.Link to Item
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Floyd, C. E., J. A. Baker, J. Y. Lo, and C. E. Ravin. “Measurement of scatter fractions in clinical bedside radiography.” Radiology 183, no. 3 (June 1992): 857–61. https://doi.org/10.1148/radiology.183.3.1584947.Full Text Link to Item
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Floyd, C. E., J. A. Baker, J. Y. Lo, and C. E. Ravin. “Posterior beam-stop method for scatter fraction measurement in digital radiography.” Invest Radiol 27, no. 2 (February 1992): 119–23. https://doi.org/10.1097/00004424-199202000-00004.Full Text Link to Item
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Berry, J. J., J. A. Baker, K. S. Pieper, M. W. Hanson, J. M. Hoffman, and R. E. Coleman. “The effect of metabolic milieu on cardiac PET imaging using fluorine-18-deoxyglucose and nitrogen-13-ammonia in normal volunteers.” J Nucl Med 32, no. 8 (August 1991): 1518–25.Link to Item
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Book Sections
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Lo, J. Y., A. O. Bilska-Wolak, J. A. Baker, G. D. Tourassi, C. E. Floyd, and M. K. Markey. “Computer-aided diagnosis in breast imaging: Where do we go after detection?” In Recent Advances in Breast Imaging, Mammography, and Computer-Aided Diagnosis of Breast Cancer, 871–900, 2006. https://doi.org/10.1117/3.651880.ch27.Full Text
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Conference Papers
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Horton, J. K., J. A. Baker, R. Blitzblau, G. S. Georgiade, E. S. Hwang, E. A. Duffy, M. Morgan, et al. “Preoperative Partial Breast Radiation Therapy: Short-term Imaging Outcomes With Two Unique Treatment Regimens.” In International Journal of Radiation Oncology*Biology*Physics, 93:E46–E46. Elsevier BV, 2015. https://doi.org/10.1016/j.ijrobp.2015.07.658.Full Text
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Horton, J. K., R. C. Blitzblau, S. Yoo, G. S. Georgiade, J. Geradts, J. A. Baker, Z. Chang, et al. “Abstract P5-14-04: Preoperative single-fraction partial breast radiotherapy – Initial results from a novel phase I dose-escalation protocol with exploration of radiation response biomarkers.” In Poster Session Abstracts. American Association for Cancer Research, 2013. https://doi.org/10.1158/0008-5472.sabcs13-p5-14-04.Full Text
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Horton, J. K., R. C. Blitzblau, S. Yoo, G. S. Georgiade, J. Geradts, J. A. Baker, Z. Chang, E. Duffy, and E. S. Hwang. “Preoperative Single-Fraction Partial Breast Radiation Therapy: A Novel Phase 1 Dose-Escalation Protocol and Exploration of Breast Cancer Radiation Response.” In International Journal of Radiation Oncology*Biology*Physics, 87:S229–S229. Elsevier BV, 2013. https://doi.org/10.1016/j.ijrobp.2013.06.594.Full Text
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Chen, Y., J. Lo, J. Baker, and J. Dobbins. “SU‐FF‐I‐21: Two‐Dimensional Shift‐And‐Add (SAA) Algorithm for Digital Breast Tomosynthesis Reconstruction.” In Medical Physics, 33:2001, 2006. https://doi.org/10.1118/1.2240260.Full Text
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Soo, M. S., J. A. Baker, S. V. Ghate, R. Walsh, B. Warwick, and K. Nightingale. “Streaming detection for evaluation of indeterminate sono-graphic breast masses - A pilot study.” In American Journal of Roentgenology, 184:27–27. AMER ROENTGEN RAY SOC, 2005.Link to Item
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Hong, A. S., J. A. Baker, J. Y. Lo, J. L. Nicholas, and M. S. Soo. “Computer-aided classification of breast masses using mammogram, ultrasound, and clinical inputs.” In American Journal of Roentgenology, 182:33–33. AMER ROENTGEN RAY SOC, 2004.Link to Item
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LO, J. Y., A. H. BAYDUSH, J. A. BAKER, P. J. KORNGUTH, and C. E. FLOYD. “COMPUTER-AIDED DIAGNOSIS OF BREAST MASS MALIGNANCY WITH AUTOMATED FEATURE-EXTRACTION AND ARTIFICIAL NEURAL NETWORKS.” In Radiology, 197:425–425, 1995.Link to Item
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