Jeanette Joan McCarthy | Scholars@Duke

Jeanette Joan McCarthy
Adjunct Associate Professor in the Department of Family Medicine and Community Health

As a genetic epidemiologist, I spent the earlier part of my career researching the genetic underpinnings of complex diseases, both infectious and chronic. More recently, I have turned my attention to precision medicine education. As a leading educator in the field of genomic and precision medicine, I now spend my time demystifying genomics for non-technical audiences, including health care providers, patients and other stakeholders. In 2014 I helped launch the first consumer-facing magazine in this field, Genome , where I served as editor-in-chief until 2016. I teach genomic and precision medicine online through Coursera and through the Precision Medicine Academy . I also design and deliver custom workshops and courses to international audiences. My workshops and online courses are meant to increase awareness, improve genomic literacy and teach practical skills for implementing precision medicine. I am also coauthor of the book, Precision Medicine: A Guide to Genomics in Clinical Practice (2016, McGraw Hill Education).

Visit: Precision Medicine Academy precisionmedicineacademy.org

Current Appointments & Affiliations

Adjunct Associate Professor in the Department of Family Medicine and Community Health, Family Medicine and Community Health, Clinical Science Departments 2011
Executive Team Member of Duke Center for Applied Genomics and Precision Medicine, Duke Center for Applied Genomics and Precision Medicine, Medicine 2014

Contact Information

905 S. Lasalle St, Gsrb-I Room 2004, Durham, NC 27710
Duke Box 3445, 905 S. Lasalle St., Durham, NC 27710
jeanette.mccarthy@duke.edu (919) 428-1914
Precision Medicine Academy
Precision Medicine Advisors

Background
Education, Training, & Certifications
- Ph.D., University of California - Berkeley 1993
- M.P.H., University of California - Berkeley 1991
Duke Appointment History
- Associate Research Professor in the Institute for Genome Sciences & Policy, Institutes and Centers, School of Medicine 2007 - 2012
- Associate Professor in Community and Family Medicine, Family Medicine and Community Health, Clinical Science Departments 2009 - 2011
- Associate Professor in Community and Family Medicine, Family Medicine and Community Health, Clinical Science Departments 2007 - 2009
- Instructor, Temporary in the Department of Community and Family Medicine, Family Medicine and Community Health, Clinical Science Departments 2007
Research
Selected Grants
- Pharmacogenetics of Lipid Response to Estrogen Therapy awarded by National Institutes of Health 2006 - 2010
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Lao, X. Q., A. Thompson, J. G. McHutchison, and J. J. McCarthy. “Sex and age differences in lipid response to chronic infection with the hepatitis C virus in the United States National Health and Nutrition Examination Surveys.” J Viral Hepat 18, no. 8 (August 2011): 571–79. https://doi.org/10.1111/j.1365-2893.2010.01347.x.
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  - Tillmann, Hans L., Alex J. Thompson, Keyur Patel, Manfred Wiese, Hannelore Tenckhoff, Hans D. Nischalke, Yuliya Lokhnygina, et al. “A polymorphism near IL28B is associated with spontaneous clearance of acute hepatitis C virus and jaundice.” Gastroenterology 139, no. 5 (November 2010): 1586-1592.e1. https://doi.org/10.1053/j.gastro.2010.07.005.
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  - Li, Josephine H., Xiang Qian Lao, Hans L. Tillmann, Jennifer Rowell, Keyur Patel, Alexander Thompson, Sunil Suchindran, et al. “Interferon-lambda genotype and low serum low-density lipoprotein cholesterol levels in patients with chronic hepatitis C infection.” Hepatology 51, no. 6 (June 2010): 1904–11. https://doi.org/10.1002/hep.23592.
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  - McCarthy, Jeanette J., Josephine H. Li, Alexander Thompson, Sunil Suchindran, Xiang Qian Lao, Keyur Patel, Hans L. Tillmann, Andrew J. Muir, and John G. McHutchison. “Replicated association between an IL28B gene variant and a sustained response to pegylated interferon and ribavirin.” Gastroenterology 138, no. 7 (June 2010): 2307–14. https://doi.org/10.1053/j.gastro.2010.02.009.
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  - Suchindran, Sunil, David Rivedal, John R. Guyton, Tom Milledge, Xiaoyi Gao, Ashlee Benjamin, Jennifer Rowell, Geoffrey S. Ginsburg, and Jeanette J. McCarthy. “Genome-wide association study of Lp-PLA(2) activity and mass in the Framingham Heart Study.” Plos Genet 6, no. 4 (April 29, 2010): e1000928. https://doi.org/10.1371/journal.pgen.1000928.
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  - Chiba-Falek, Ornit, Marshall Nichols, Sunil Suchindran, John Guyton, Geoffrey S. Ginsburg, Elizabeth Barrett-Connor, and Jeanette J. McCarthy. “Impact of gene variants on sex-specific regulation of human Scavenger receptor class B type 1 (SR-BI) expression in liver and association with lipid levels in a population-based study.” Bmc Med Genet 11 (January 19, 2010): 9. https://doi.org/10.1186/1471-2350-11-9.
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  - Suchindran, Sunil, Alicia M. Vana, Richard A. Shaffer, John E. Alcaraz, and Jeanette J. McCarthy. “Racial differences in the interaction between family history and risk factors associated with diabetes in the National Health and Nutritional Examination Survey, 1999-2004.” Genet Med 11, no. 7 (July 2009): 542–47. https://doi.org/10.1097/GIM.0b013e3181a70917.
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  - McCarthy, Jeanette J., Aleefia Somji, Lauren A. Weiss, Brian Steffy, Raquel Vega, Elizabeth Barrett-Connor, Gregory Talavera, and Richard Glynne. “Polymorphisms of the scavenger receptor class B member 1 are associated with insulin resistance with evidence of gene by sex interaction.” J Clin Endocrinol Metab 94, no. 5 (May 2009): 1789–96. https://doi.org/10.1210/jc.2008-2800.
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  - McCarthy, Jeanette J., and Eric J. Topol. “Validity of reported genetic risk factors for acute coronary syndrome.” Jama 298, no. 15 (October 17, 2007): 1758. https://doi.org/10.1001/jama.298.15.1758-a.
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  - Ginsburg, Geoffrey S., Svati H. Shah, and Jeanette J. McCarthy. “Taking cardiovascular genetic association studies to the next level.” J Am Coll Cardiol 50, no. 10 (September 4, 2007): 930–32. https://doi.org/10.1016/j.jacc.2007.05.025.
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  - Nelson, Tamara, Angelica Perez, John Alcaraz, Gregory Talavera, and Jeanette J. McCarthy. “Family History of Diabetes, Acculturation, and the Metabolic Syndrome among Mexican Americans: Proyecto SALSA.” Metab Syndr Relat Disord 5, no. 3 (September 2007): 262–69. https://doi.org/10.1089/met.2006.0035.
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  - McCarthy, Jeanette J. “Gene by sex interaction in the etiology of coronary heart disease and the preceding metabolic syndrome.” Nutr Metab Cardiovasc Dis 17, no. 2 (February 2007): 153–61. https://doi.org/10.1016/j.numecd.2006.01.005.
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  - McCarthy, Jeanette. “Life, diversity and the pursuit of haplotypes.” Nat Biotechnol 23, no. 11 (November 2005): 1376–77. https://doi.org/10.1038/nbt1105-1376.
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  - Moss, Arthur J., Daniel Ryan, David Oakes, Robert E. Goldstein, Henry Greenberg, Monty M. Bodenheimer, Mary W. Brown, et al. “Atherosclerotic risk genotypes and recurrent coronary events after myocardial infarction.” Am J Cardiol 96, no. 2 (July 15, 2005): 177–82. https://doi.org/10.1016/j.amjcard.2005.03.039.
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  - Richard, Erin, Denise von Muhlen, Elizabeth Barrett-Connor, John Alcaraz, Roger Davis, and Jeanette J. McCarthy. “Modification of the effects of estrogen therapy on HDL cholesterol levels by polymorphisms of the HDL-C receptor, SR-BI: the Rancho Bernardo Study.” Atherosclerosis 180, no. 2 (June 2005): 255–62. https://doi.org/10.1016/j.atherosclerosis.2004.12.013.
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  - Jefferson, Brian K., Jennifer H. Foster, Jeanette J. McCarthy, Geoffrey Ginsburg, Alex Parker, Kandice Kottke-Marchant, and Eric J. Topol. “Aspirin resistance and a single gene.” Am J Cardiol 95, no. 6 (March 15, 2005): 805–8. https://doi.org/10.1016/j.amjcard.2004.11.045.
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  - Stenina, Olga I., Tatiana V. Byzova, Josephine C. Adams, Jeanette J. McCarthy, Eric J. Topol, and Edward F. Plow. “Coronary artery disease and the thrombospondin single nucleotide polymorphisms.” Int J Biochem Cell Biol 36, no. 6 (June 2004): 1013–30. https://doi.org/10.1016/j.biocel.2004.01.005.
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  - McCarthy, J. J., A. Parker, R. Salem, D. J. Moliterno, Q. Wang, E. F. Plow, S. Rao, et al. “Large scale association analysis for identification of genes underlying premature coronary heart disease: cumulative perspective from analysis of 111 candidate genes.” J Med Genet 41, no. 5 (May 2004): 334–41. https://doi.org/10.1136/jmg.2003.016584.
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  - Wessel, Jennifer, Eric J. Topol, Ming Ji, Joanne Meyer, and Jeanette J. McCarthy. “Replication of the association between the thrombospondin-4 A387P polymorphism and myocardial infarction.” Am Heart J 147, no. 5 (May 2004): 905–9. https://doi.org/10.1016/j.ahj.2003.12.013.
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  - Gayà, Antoni, Anna Esteve, Jordi Casabona, Jeanette J. McCarthy, Jaume Martorell, Thomas F. Schulz, Denise Whitby, and Denise EURO-SHAKS working group. “Amino acid residue at position 13 in HLA-DR beta chain plays a critical role in the development of Kaposi's sarcoma in AIDS patients.” Aids 18, no. 2 (January 23, 2004): 199–204. https://doi.org/10.1097/00002030-200401230-00008.
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  - McCarthy, Jeanette J., Joanne Meyer, David J. Moliterno, L Kristin Newby, William J. Rogers, Eric J. Topol, and Eric J. GenQuest multicenter study. “Evidence for substantial effect modification by gender in a large-scale genetic association study of the metabolic syndrome among coronary heart disease patients.” Hum Genet 114, no. 1 (December 2003): 87–98. https://doi.org/10.1007/s00439-003-1026-1.
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  - McCarthy, Jeanette J. “Advances in pharmacogenomic research and development.” Mol Biotechnol 25, no. 3 (November 2003): 275–82. https://doi.org/10.1385/MB:25:3:275.
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  - McCarthy, J. J., T. Lehner, C. Reeves, D. J. Moliterno, L. K. Newby, W. J. Rogers, E. J. Topol, and E. J. Genequest investigators. “Association of genetic variants in the HDL receptor, SR-B1, with abnormal lipids in women with coronary artery disease.” J Med Genet 40, no. 6 (June 2003): 453–58. https://doi.org/10.1136/jmg.40.6.453.
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  - McCarthy, Jeanette J., Steve Lewitzky, Cynthia Reeves, Alan Permutt, Benjamin Glaser, Leif C. Groop, Thomas Lehner, and Joanne M. Meyer. “Polymorphisms of the HDL receptor gene associated with HDL cholesterol levels in diabetic kindred from three populations.” Hum Hered 55, no. 4 (2003): 163–70. https://doi.org/10.1159/000073986.
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  - Ginsburg, G. S., and J. J. McCarthy. “Personalized medicine: revolutionizing drug discovery and patient care.” Trends Biotechnol 19, no. 12 (December 2001): 491–96. https://doi.org/10.1016/s0167-7799(01)01814-5.
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  - Topol, E. J., J. McCarthy, S. Gabriel, D. J. Moliterno, W. J. Rogers, L. K. Newby, M. Freedman, et al. “Single nucleotide polymorphisms in multiple novel thrombospondin genes may be associated with familial premature myocardial infarction.” Circulation 104, no. 22 (November 27, 2001): 2641–44. https://doi.org/10.1161/hc4701.100910.
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  - Duncan, L. M., J. Deeds, F. E. Cronin, M. Donovan, A. J. Sober, M. Kauffman, and J. J. McCarthy. “Melastatin expression and prognosis in cutaneous malignant melanoma.” J Clin Oncol 19, no. 2 (January 15, 2001): 568–76. https://doi.org/10.1200/JCO.2001.19.2.568.
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  - McCarthy, J. “The true nature of pharmacogenomic associations?” Trends Pharmacol Sci 21, no. 12 (December 1, 2000): 461. https://doi.org/10.1016/s0165-6147(00)01595-9.
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  - McCarthy, J. J. “Genetic studies: look no further than your own backyard.” Trends Biotechnol 18, no. 11 (November 2000): 441. https://doi.org/10.1016/s0167-7799(00)01503-1.
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  - McCarthy, J. “Genetic studies: look no further than your own backyard.” Trends Genet 16, no. 10 (October 2000): 440. https://doi.org/10.1016/s0168-9525(00)02129-6.
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  - McCarthy, J. J., and R. Hilfiker. “The use of single-nucleotide polymorphism maps in pharmacogenomics.” Nat Biotechnol 18, no. 5 (May 2000): 505–8. https://doi.org/10.1038/75360.
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  - Chen, J. J., J. A. Hollenbach, E. A. Trachtenberg, J. J. Just, M. Carrington, K. S. Rønningen, A. Begovich, et al. “Hardy-Weinberg testing for HLA class II (DRB1, DQA1, DQB1, and DPB1) loci in 26 human ethnic groups.” Tissue Antigens 54, no. 6 (December 1999): 533–42. https://doi.org/10.1034/j.1399-0039.1999.540601.x.
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  - Rousseau, C. M., J. J. Just, E. J. Abrams, J. Casabona, Z. Stein, and M. C. King. “CCR5del32 in perinatal HIV-1 infection.” J Acquir Immune Defic Syndr Hum Retrovirol 16, no. 4 (December 1, 1997): 239–42. https://doi.org/10.1097/00042560-199712010-00003.
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  - Lloyd, C. M., J. A. Gonzalo, D. J. Salant, J. Just, and J. C. Gutierrez-Ramos. “Intercellular adhesion molecule-1 deficiency prolongs survival and protects against the development of pulmonary inflammation during murine lupus.” J Clin Invest 100, no. 5 (September 1, 1997): 963–71. https://doi.org/10.1172/JCI119647.
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  - Just, J. J., M. C. King, G. Thomson, and W. Klitz. “African-American HLA class II allele and haplotype diversity.” Tissue Antigens 49, no. 5 (May 1997): 547–55. https://doi.org/10.1111/j.1399-0039.1997.tb02801.x.
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  - Stanford, J. L., J. J. Just, M. Gibbs, K. G. Wicklund, C. L. Neal, B. A. Blumenstein, and E. A. Ostrander. “Polymorphic repeats in the androgen receptor gene: molecular markers of prostate cancer risk.” Cancer Res 57, no. 6 (March 15, 1997): 1194–98.
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  - Just, J. J., M. C. King, G. Thomson, and W. Klitz. “African-American HLA class II allele and haplotype diversity.” Tissue Antigens 48, no. 6 (December 1996): 636–44. https://doi.org/10.1111/j.1399-0039.1996.tb02686.x.
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  - Just, J. J., J. Casabona, J. Bertrán, C. Montané, C. Fortuny, C. Rodrigo, A. Mur, M. Bosque, L. Jovane, and M. C. King. “MHC class II alleles associated with clinical and immunological manifestations of HIV-1 infection among children in Catalonia, Spain.” Tissue Antigens 47, no. 4 (April 1996): 313–18. https://doi.org/10.1111/j.1399-0039.1996.tb02559.x.
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  - Keet, I. P., M. R. Klein, J. J. Just, and R. A. Kaslow. “The role of host genetics in the natural history of HIV-1 infection: the needles in the haystack.” Aids 10 Suppl A (1996): S59–67. https://doi.org/10.1097/00002030-199601001-00009.
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  - Just, J. J. “Genetic predisposition to HIV-1 infection and acquired immune deficiency virus syndrome: a review of the literature examining associations with HLA [corrected].” Hum Immunol 44, no. 3 (November 1995): 156–69. https://doi.org/10.1016/0198-8859(95)00034-8.
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  - Just, J. J., E. Abrams, L. G. Louie, R. Urbano, D. Wara, S. W. Nicholas, Z. Stein, and M. C. King. “Influence of host genotype on progression to acquired immunodeficiency syndrome among children infected with human immunodeficiency virus type 1.” The Journal of Pediatrics 127, no. 4 (October 1995): 544–49. https://doi.org/10.1016/s0022-3476(95)70110-9.
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  - Just, J., L. Louie, E. Abrams, S. W. Nicholas, D. Wara, Z. Stein, and M. C. King. “Genetic risk factors for perinatally acquired HIV-1 infection.” Paediatr Perinat Epidemiol 6, no. 2 (April 1992): 215–24. https://doi.org/10.1111/j.1365-3016.1992.tb00762.x.
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  - Just, J., and T. Markow. “Success of mutant Drosophila at different sex ratios.” Hereditas 110, no. 1 (1989): 51–53. https://doi.org/10.1111/j.1601-5223.1989.tb00416.x.
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Education, Training, & Certifications

Duke Appointment History

Selected Grants

Selected Publications

Academic Articles