Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., University of California at Berkeley 1993
  • M.P.H., University of California at Berkeley 1991
• 

  Duke Appointment History

  • Associate Research Professor in the Institute for Genome Sciences & Policy, Institutes and Centers, School of Medicine 2007 - 2012
  • Associate Professor in Community and Family Medicine, Community and Family Medicine, Clinical Science Departments 2009 - 2011
  • Associate Professor in Community and Family Medicine, Community and Family Medicine, Clinical Science Departments 2007 - 2009
  • Instructor, Temporary in the Department of Community and Family Medicine, Community and Family Medicine, Clinical Science Departments 2007
• Research
• 

  Selected Grants

  • Pharmacogenetics of Lipid Response to Estrogen Therapy awarded by National Institutes of Health 2006 - 2010
• Publications & Artistic Works
• 

  Selected Publications

  • Journal Articles

    • Lao, XQ, Thompson, A, McHutchison, JG, and McCarthy, JJ. "Sex and age differences in lipid response to chronic infection with the hepatitis C virus in the United States National Health and Nutrition Examination Surveys." J Viral Hepat 18, no. 8 (August 2011): 571-579.  Full Text  Link to Item
    • Tillmann, HL, Thompson, AJ, Patel, K, Wiese, M, Tenckhoff, H, Nischalke, HD, Lokhnygina, Y, Kullig, U, Göbel, U, Capka, E, Wiegand, J, Schiefke, I, Güthoff, W, Grüngreiff, K, König, I, Spengler, U, McCarthy, J, Shianna, KV, Goldstein, DB, McHutchison, JG, Timm, J, Nattermann, J, and German Anti-D Study Group, . "A polymorphism near IL28B is associated with spontaneous clearance of acute hepatitis C virus and jaundice." Gastroenterology 139, no. 5 (November 2010): 1586-1592.e1.  Full Text  Link to Item
    • Li, JH, Lao, XQ, Tillmann, HL, Rowell, J, Patel, K, Thompson, A, Suchindran, S, Muir, AJ, Guyton, JR, Gardner, SD, McHutchison, JG, and McCarthy, JJ. "Interferon-lambda genotype and low serum low-density lipoprotein cholesterol levels in patients with chronic hepatitis C infection." Hepatology 51, no. 6 (June 2010): 1904-1911.  Full Text  Link to Item
    • McCarthy, JJ, Li, JH, Thompson, A, Suchindran, S, Lao, XQ, Patel, K, Tillmann, HL, Muir, AJ, and McHutchison, JG. "Replicated association between an IL28B gene variant and a sustained response to pegylated interferon and ribavirin." Gastroenterology 138, no. 7 (June 2010): 2307-2314.  Full Text  Link to Item
    • Suchindran, S, Rivedal, D, Guyton, JR, Milledge, T, Gao, X, Benjamin, A, Rowell, J, Ginsburg, GS, and McCarthy, JJ. "Genome-wide association study of Lp-PLA(2) activity and mass in the Framingham Heart Study. (Published online)" PLoS Genet 6, no. 4 (April 29, 2010): e1000928-.  Full Text  Open Access Copy  Link to Item
    • Chiba-Falek, O, Nichols, M, Suchindran, S, Guyton, J, Ginsburg, GS, Barrett-Connor, E, and McCarthy, JJ. "Impact of gene variants on sex-specific regulation of human Scavenger receptor class B type 1 (SR-BI) expression in liver and association with lipid levels in a population-based study. (Published online)" BMC Med Genet 11 (January 19, 2010): 9-.  Full Text  Open Access Copy  Link to Item
    • Suchindran, S, Vana, AM, Shaffer, RA, Alcaraz, JE, and McCarthy, JJ. "Racial differences in the interaction between family history and risk factors associated with diabetes in the National Health and Nutritional Examination Survey, 1999-2004." Genet Med 11, no. 7 (July 2009): 542-547.  Full Text  Link to Item
    • McCarthy, JJ, Somji, A, Weiss, LA, Steffy, B, Vega, R, Barrett-Connor, E, Talavera, G, and Glynne, R. "Polymorphisms of the scavenger receptor class B member 1 are associated with insulin resistance with evidence of gene by sex interaction." J Clin Endocrinol Metab 94, no. 5 (May 2009): 1789-1796.  Full Text  Link to Item
    • McCarthy, JJ, and Topol, EJ. "Validity of reported genetic risk factors for acute coronary syndrome." JAMA 298, no. 15 (October 17, 2007): 1758-. (Letter)  Full Text  Link to Item
    • Ginsburg, GS, Shah, SH, and McCarthy, JJ. "Taking cardiovascular genetic association studies to the next level." J Am Coll Cardiol 50, no. 10 (September 4, 2007): 930-932.  Full Text  Link to Item
    • Nelson, T, Perez, A, Alcaraz, J, Talavera, G, and McCarthy, JJ. "Family History of Diabetes, Acculturation, and the Metabolic Syndrome among Mexican Americans: Proyecto SALSA." Metab Syndr Relat Disord 5, no. 3 (September 2007): 262-269.  Full Text  Link to Item
    • McCarthy, JJ. "Gene by sex interaction in the etiology of coronary heart disease and the preceding metabolic syndrome." Nutr Metab Cardiovasc Dis 17, no. 2 (February 2007): 153-161. (Review)  Full Text  Link to Item
    • McCarthy, J. "Life, diversity and the pursuit of haplotypes." Nat Biotechnol 23, no. 11 (November 2005): 1376-1377.  Full Text  Link to Item
    • Moss, AJ, Ryan, D, Oakes, D, Goldstein, RE, Greenberg, H, Bodenheimer, MM, Brown, MW, Case, RB, Dwyer, EM, Eberly, SW, Francis, CW, Gillespie, JA, Krone, RJ, Lichstein, E, MacCluer, JW, Marcus, FI, McCarthy, J, Sparks, CE, and Zareba, W. "Atherosclerotic risk genotypes and recurrent coronary events after myocardial infarction." Am J Cardiol 96, no. 2 (July 15, 2005): 177-182.  Full Text  Link to Item
    • Richard, E, von Muhlen, D, Barrett-Connor, E, Alcaraz, J, Davis, R, and McCarthy, JJ. "Modification of the effects of estrogen therapy on HDL cholesterol levels by polymorphisms of the HDL-C receptor, SR-BI: the Rancho Bernardo Study." Atherosclerosis 180, no. 2 (June 2005): 255-262.  Full Text  Link to Item
    • Jefferson, BK, Foster, JH, McCarthy, JJ, Ginsburg, G, Parker, A, Kottke-Marchant, K, and Topol, EJ. "Aspirin resistance and a single gene." Am J Cardiol 95, no. 6 (March 15, 2005): 805-808.  Full Text  Link to Item
    • Stenina, OI, Byzova, TV, Adams, JC, McCarthy, JJ, Topol, EJ, and Plow, EF. "Coronary artery disease and the thrombospondin single nucleotide polymorphisms." Int J Biochem Cell Biol 36, no. 6 (June 2004): 1013-1030. (Review)  Full Text  Link to Item
    • McCarthy, JJ, Parker, A, Salem, R, Moliterno, DJ, Wang, Q, Plow, EF, Rao, S, Shen, G, Rogers, WJ, Newby, LK, Cannata, R, Glatt, K, Topol, EJ, and GeneQuest Investigators, . "Large scale association analysis for identification of genes underlying premature coronary heart disease: cumulative perspective from analysis of 111 candidate genes." J Med Genet 41, no. 5 (May 2004): 334-341.  Link to Item
    • Wessel, J, Topol, EJ, Ji, M, Meyer, J, and McCarthy, JJ. "Replication of the association between the thrombospondin-4 A387P polymorphism and myocardial infarction." Am Heart J 147, no. 5 (May 2004): 905-909.  Full Text  Link to Item
    • Gayà, A, Esteve, A, Casabona, J, McCarthy, JJ, Martorell, J, Schulz, TF, Whitby, D, and EURO-SHAKS working group, . "Amino acid residue at position 13 in HLA-DR beta chain plays a critical role in the development of Kaposi's sarcoma in AIDS patients." AIDS 18, no. 2 (January 23, 2004): 199-204.  Link to Item
    • McCarthy, JJ, Meyer, J, Moliterno, DJ, Newby, LK, Rogers, WJ, Topol, EJ, and GenQuest multicenter study, . "Evidence for substantial effect modification by gender in a large-scale genetic association study of the metabolic syndrome among coronary heart disease patients." Hum Genet 114, no. 1 (December 2003): 87-98.  Full Text  Link to Item
    • McCarthy, JJ. "Advances in pharmacogenomic research and development." Mol Biotechnol 25, no. 3 (November 2003): 275-282. (Review)  Full Text  Link to Item
    • McCarthy, JJ, Lehner, T, Reeves, C, Moliterno, DJ, Newby, LK, Rogers, WJ, Topol, EJ, and Genequest investigators, . "Association of genetic variants in the HDL receptor, SR-B1, with abnormal lipids in women with coronary artery disease." J Med Genet 40, no. 6 (June 2003): 453-458. (Letter)  Link to Item
    • McCarthy, JJ, Lewitzky, S, Reeves, C, Permutt, A, Glaser, B, Groop, LC, Lehner, T, and Meyer, JM. "Polymorphisms of the HDL receptor gene associated with HDL cholesterol levels in diabetic kindred from three populations." Hum Hered 55, no. 4 (2003): 163-170.  Full Text  Link to Item
    • Ginsburg, GS, and McCarthy, JJ. "Personalized medicine: revolutionizing drug discovery and patient care." Trends Biotechnol 19, no. 12 (December 2001): 491-496.  Link to Item
    • Topol, EJ, McCarthy, J, Gabriel, S, Moliterno, DJ, Rogers, WJ, Newby, LK, Freedman, M, Metivier, J, Cannata, R, O'Donnell, CJ, Kottke-Marchant, K, Murugesan, G, Plow, EF, Stenina, O, and Daley, GQ. "Single nucleotide polymorphisms in multiple novel thrombospondin genes may be associated with familial premature myocardial infarction." Circulation 104, no. 22 (November 27, 2001): 2641-2644.  Link to Item
    • Duncan, LM, Deeds, J, Cronin, FE, Donovan, M, Sober, AJ, Kauffman, M, and McCarthy, JJ. "Melastatin expression and prognosis in cutaneous malignant melanoma." J Clin Oncol 19, no. 2 (January 15, 2001): 568-576.  Full Text  Link to Item
    • McCarthy, J. "The true nature of pharmacogenomic associations?." Trends Pharmacol Sci 21, no. 12 (December 1, 2000): 461-.  Link to Item
    • McCarthy, JJ. "Genetic studies: look no further than your own backyard." Trends Biotechnol 18, no. 11 (November 2000): 441-.  Link to Item
    • McCarthy, J. "Genetic studies: look no further than your own backyard." Trends Genet 16, no. 10 (October 2000): 440-.  Link to Item
    • McCarthy, JJ, and Hilfiker, R. "The use of single-nucleotide polymorphism maps in pharmacogenomics." Nat Biotechnol 18, no. 5 (May 2000): 505-508. (Review)  Full Text  Link to Item
    • Chen, JJ, Hollenbach, JA, Trachtenberg, EA, Just, JJ, Carrington, M, Rønningen, KS, Begovich, A, King, MC, McWeeney, S, Mack, SJ, Erlich, HA, and Thomson, G. "Hardy-Weinberg testing for HLA class II (DRB1, DQA1, DQB1, and DPB1) loci in 26 human ethnic groups." Tissue Antigens 54, no. 6 (December 1999): 533-542.  Link to Item
    • Rousseau, CM, Just, JJ, Abrams, EJ, Casabona, J, Stein, Z, and King, MC. "CCR5del32 in perinatal HIV-1 infection." J Acquir Immune Defic Syndr Hum Retrovirol 16, no. 4 (December 1, 1997): 239-242.  Link to Item
    • Lloyd, CM, Gonzalo, JA, Salant, DJ, Just, J, and Gutierrez-Ramos, JC. "Intercellular adhesion molecule-1 deficiency prolongs survival and protects against the development of pulmonary inflammation during murine lupus." J Clin Invest 100, no. 5 (September 1, 1997): 963-971.  Full Text  Link to Item
    • Just, JJ, King, MC, Thomson, G, and Klitz, W. "African-American HLA class II allele and haplotype diversity." Tissue Antigens 49, no. 5 (May 1997): 547-555.  Link to Item
    • Stanford, JL, Just, JJ, Gibbs, M, Wicklund, KG, Neal, CL, Blumenstein, BA, and Ostrander, EA. "Polymorphic repeats in the androgen receptor gene: molecular markers of prostate cancer risk." Cancer Res 57, no. 6 (March 15, 1997): 1194-1198.  Link to Item
    • Just, JJ, King, MC, Thomson, G, and Klitz, W. "African-American HLA class II allele and haplotype diversity." Tissue Antigens 48, no. 6 (December 1996): 636-644.  Link to Item
    • Just, JJ, Casabona, J, Bertrán, J, Montané, C, Fortuny, C, Rodrigo, C, Mur, A, Bosque, M, Jovane, L, and King, MC. "MHC class II alleles associated with clinical and immunological manifestations of HIV-1 infection among children in Catalonia, Spain." Tissue Antigens 47, no. 4 (April 1996): 313-318.  Link to Item
    • Keet, IP, Klein, MR, Just, JJ, and Kaslow, RA. "The role of host genetics in the natural history of HIV-1 infection: the needles in the haystack." AIDS 10 Suppl A (1996): S59-S67. (Review)  Link to Item
    • Just, JJ. "Genetic predisposition to HIV-1 infection and acquired immune deficiency virus syndrome: a review of the literature examining associations with HLA [corrected]." Hum Immunol 44, no. 3 (November 1995): 156-169. (Review)  Link to Item
    • Just, JJ, Abrams, E, Louie, LG, Urbano, R, Wara, D, Nicholas, SW, Stein, Z, and King, MC. "Influence of host genotype on progression to acquired immunodeficiency syndrome among children infected with human immunodeficiency virus type 1." J Pediatr 127, no. 4 (October 1995): 544-549.  Link to Item
    • Just, J, Louie, L, Abrams, E, Nicholas, SW, Wara, D, Stein, Z, and King, MC. "Genetic risk factors for perinatally acquired HIV-1 infection." Paediatr Perinat Epidemiol 6, no. 2 (April 1992): 215-224.  Link to Item
    • Just, J, and Markow, T. "Success of mutant Drosophila at different sex ratios." Hereditas 110, no. 1 (1989): 51-53.  Link to Item

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