Jeffrey Charles Rathmell

Jeffrey Charles Rathmell
Adjunct Associate Professor in the Department of Pharmacology and Cancer Biology

My laboratory studies the mechanisms and role of glucose metabolism in lymphocyte survival and activation. We have found that dramatic increases in glucose metabolism are necessary for lymphocytes to survive and mount immune responses. Excessive glucose metabolism, however, can lead to T cell hyperactivation and autoimmunity. A key mechanism for control of lymphocyte glucose metabolism is regulation of glucose uptake by the glucose transporter, Glut1. Interestingly, upregulation of Glut1 and glucose metabolism has also long been observed in cancer cells of all varieties and this may play an important role in cancer cell growth and survival. It remains unknown, however, how Glut1 expression or localization is regulated and how alterations in glucose uptake may affect immunity or cancer. To address this issue we are taking three approaches.

(1) Determine the signal transduction mechanisms that regulate Glut1 expression and intracellular trafficking.
(2) We have generated Glut1 transgenic mice that express Glut1 specifically in T cells and are making a conditional Glut1 knockout mouse to study the role of glucose uptake in T cell activation and regulation of Bcl-2 family proteins.
(3) We are also addressing how alterations in glucose uptake may affect development of cancer and if leukemias may become “metabolically addicted” to high glucose metabolism.

Our approach of studying the mechanism and role of metabolic regulation in lymphocytes bridges immunology and metabolism research. Ultimately, understanding this problem may lead to new metabolic approaches to immune and cancer therapies.

Current Appointments & Affiliations

Adjunct Associate Professor in the Department of Pharmacology and Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2015
Member of Sarah W. Stedman Nutrition & Metabolism Center, Sarah Stedman Nutrition & Metabolism Center, Duke Molecular Physiology Institute 2003

Contact Information

Duke Box 3813, Durham, NC 27710
LSRC C338, Durham, NC 27710
jeff.rathmell@duke.edu (919) 681-1084

Background
Education, Training, & Certifications
- Ph.D., Stanford University 1996
Previous Appointments & Affiliations
- Associate Professor of Immunology, Integrative Immunobiology, Basic Science Departments 2010 - 2016
- Associate Professor of Pharmacology & Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2010 - 2015
- Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2003 - 2015
- Assistant Professor in Pharmacology & Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2003 - 2010
- Assistant Professor of Immunology, Integrative Immunobiology, Basic Science Departments 2005 - 2010
Research
Selected Grants
- Training Program in Inflammatory and Immunological Diseases awarded by National Institutes of Health 1980 - 2017
- Targeting aerobic glycolysis in T-ALL awarded by National Institutes of Health 2014 - 2016
- Cancer Biology Training Grant awarded by National Cancer Institute 1993 - 2016
- Exploiting metabolic vulnerabilities of CD4 T cell subsets to control inflammatory awarded by National Institutes of Health 2015
- New Approaches to Cardiothoracic Tolerance Induction awarded by Massachusetts General Hospital 2014 - 2015
- Metabolism of Effector T cells as a Target in SLE awarded by Alliance for Lupus Research 2014 - 2015
- T cell metabolism as a determinant of differentiation in allergic asthma awarded by National Institutes of Health 2011 - 2015
- B cell metabolism in activation and autoantibody production awarded by National Institutes of Health 2013 - 2015
- Autophagy in T lymphocyte function awarded by National Institutes of Health 2009 - 2015
- Glucose uptake and metabolism in lymphocyte fate and inflammatory bowel disease awarded by Crohn's & Colitis Foundation of America, Inc. 2014 - 2015
- Leptin as a Regulator of T Cell Metabolism and Function awarded by National Institutes of Health 2010 - 2015
- BcI-2 family in T lymphocyte homeostasis awarded by National Institutes of Health 2008 - 2014
- Metabolic Control of T Cell Subsets and Pyruvate Dehydrogenase Kinase as a Target in Inflammatory Bowel Disease awarded by Kenneth Rainin Foundation 2013 - 2014
- Glucose Transport in Regulation of T Cell Activation and Inflammation awarded by National Institutes of Health 2012 - 2014
- Glucose metabolism and cell death in cancer awarded by National Institutes of Health 2007 - 2014
- Molecular mechanisms of chemoresistance in breast cancer awarded by National Institutes of Health 2010 - 2012
- The Role of PTEN in Endothelial Biology awarded by National Institutes of Health 2008 - 2012
- Trophic Regulation in T Cell Homeostasis and Disease awarded by National Institutes of Health 2006 - 2012
- Glucose Metabolism and p53 in Leukemia awarded by National Institutes of Health 2008 - 2011
- Live cell widefield fluorescence microscope with activation and bleaching lasers awarded by National Institutes of Health 2010 - 2011
- Multispectral Imaging Flow Cytometer Core awarded by National Institutes of Health 2010 - 2011
- Macrophage Mitochondrial Stress in Inflammation, Insulin Resistance & Obesity awarded by National Institutes of Health 2007 - 2010
- Control of lymphocyte trophic state by extrinsic signals awarded by National Institutes of Health 2003 - 2006
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Gong, Minghao, Seung-Chul Choi, Yuk Pheel Park, Xueyang Zou, Ahmed S. Elshikha, Valerie A. Gerriets, Jeffrey C. Rathmell, Mansour Mohamazadeh, and Laurence Morel. “Transcriptional and metabolic programs promote the expansion of follicular helper T cells in lupus-prone mice.” Iscience 26, no. 5 (May 19, 2023): 106774. https://doi.org/10.1016/j.isci.2023.106774.
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  - Wang-Bishop, Lihong, Blaise R. Kimmel, Verra M. Ngwa, Matthew Z. Madden, Jessalyn J. Baljon, David C. Florian, Ann Hanna, et al. “STING-activating nanoparticles normalize the vascular-immune interface to potentiate cancer immunotherapy.” Sci Immunol 8, no. 83 (May 12, 2023): eadd1153. https://doi.org/10.1126/sciimmunol.add1153.
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  - Hinshaw, Dominique C., Gloria A. Benavides, Brandon J. Metge, Courtney A. Swain, Sarah C. Kammerud, Heba A. Alsheikh, Amr Elhamamsy, et al. “Hedgehog Signaling Regulates Treg to Th17 Conversion Through Metabolic Rewiring in Breast Cancer.” Cancer Immunol Res 11, no. 5 (May 3, 2023): 687–702. https://doi.org/10.1158/2326-6066.CIR-22-0426.
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  - Cable, Jennifer, Jeffrey C. Rathmell, Erika L. Pearce, Ping-Chih Ho, Marcia C. Haigis, Murad R. Mamedov, Meng-Ju Wu, et al. “Immunometabolism at the crossroads of obesity and cancer-a Keystone Symposia report.” Ann N Y Acad Sci 1523, no. 1 (May 2023): 38–50. https://doi.org/10.1111/nyas.14976.
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  - Rathmell, Jeffrey. “The good side of science: why I tweeted 31 reasons to love your career.” Nature, April 7, 2023. https://doi.org/10.1038/d41586-023-01027-8.
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  - Li, Huihui, Caroline Guglielmetti, Yoshitaka J. Sei, Misha Zilberter, Lydia M. Le Page, Lauren Shields, Joyce Yang, et al. “Neurons require glucose uptake and glycolysis in vivo.” Cell Reports 42, no. 4 (April 2023): 112335. https://doi.org/10.1016/j.celrep.2023.112335.
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  - Arner, Emily N., and Jeffrey C. Rathmell. “Metabolic programming and immune suppression in the tumor microenvironment.” Cancer Cell 41, no. 3 (March 13, 2023): 421–33. https://doi.org/10.1016/j.ccell.2023.01.009.
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  - Voss, Kelsey, Allison E. Sewell, Evan S. Krystofiak, Katherine N. Gibson-Corley, Arissa C. Young, Jacob H. Basham, Ayaka Sugiura, et al. “Elevated transferrin receptor impairs T cell metabolism and function in systemic lupus erythematosus.” Sci Immunol 8, no. 79 (January 13, 2023): eabq0178. https://doi.org/10.1126/sciimmunol.abq0178.
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  - Song, Wenqiang, J Luke Postoak, Guan Yang, Xingyi Guo, Heather H. Pua, Jackie Bader, Jeffrey C. Rathmell, et al. “Lipid kinase PIK3C3 maintains healthy brown and white adipose tissues to prevent metabolic diseases.” Proc Natl Acad Sci U S A 120, no. 1 (January 3, 2023): e2214874120. https://doi.org/10.1073/pnas.2214874120.
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  - Baregamian, Naira, Konjeti R. Sekhar, Evan S. Krystofiak, Maria Vinogradova, Giju Thomas, Emmanuel Mannoh, Carmen C. Solórzano, et al. “Engineering functional 3-dimensional patient-derived endocrine organoids for broad multiplatform applications.” Surgery 173, no. 1 (January 2023): 67–75. https://doi.org/10.1016/j.surg.2022.09.027.
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  - Pham, Ly, Padmini Komalavilas, Alex M. Eddie, Timothy E. Thayer, Dalton L. Greenwood, Ken H. Liu, Jaclyn Weinberg, et al. “Neutrophil trafficking to the site of infection requires Cpt1a-dependent fatty acid β-oxidation.” Commun Biol 5, no. 1 (December 13, 2022): 1366. https://doi.org/10.1038/s42003-022-04339-z.
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  - Greenwood, Dalton L., Haley E. Ramsey, Phuong T. T. Nguyen, Andrew R. Patterson, Kelsey Voss, Jackie E. Bader, Ayaka Sugiura, et al. “Acly Deficiency Enhances Myelopoiesis through Acetyl Coenzyme A and Metabolic-Epigenetic Cross-Talk.” Immunohorizons 6, no. 12 (December 1, 2022): 837–50. https://doi.org/10.4049/immunohorizons.2200086.
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  - Axelrod, Margaret L., Wouter C. Meijers, Elles M. Screever, Juan Qin, Mary Grace Carroll, Xiaopeng Sun, Elie Tannous, et al. “T cells specific for α-myosin drive immunotherapy-related myocarditis.” Nature 611, no. 7937 (November 2022): 818–26. https://doi.org/10.1038/s41586-022-05432-3.
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  - Wong, Hong Yuen, Quanhu Sheng, Amanda B. Hesterberg, Sarah Croessmann, Brenda L. Rios, Khem Giri, Jorgen Jackson, et al. “Single cell analysis of cribriform prostate cancer reveals cell intrinsic and tumor microenvironmental pathways of aggressive disease.” Nature Communications 13, no. 1 (October 2022): 6036. https://doi.org/10.1038/s41467-022-33780-1.
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  - Groves, Sarah M., Geena V. Ildefonso, Caitlin O. McAtee, Patricia M. M. Ozawa, Abbie S. Ireland, Philip E. Stauffer, Perry T. Wasdin, et al. “Archetype tasks link intratumoral heterogeneity to plasticity and cancer hallmarks in small cell lung cancer.” Cell Syst 13, no. 9 (September 21, 2022): 690-710.e17. https://doi.org/10.1016/j.cels.2022.07.006.
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  - Beebout, Connor J., Gabriella L. Robertson, Bradley I. Reinfeld, Alexandra M. Blee, Grace H. Morales, John R. Brannon, Walter J. Chazin, et al. “Uropathogenic Escherichia coli subverts mitochondrial metabolism to enable intracellular bacterial pathogenesis in urinary tract infection.” Nat Microbiol 7, no. 9 (September 2022): 1348–60. https://doi.org/10.1038/s41564-022-01205-w.
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  - Zielke, Claudia, Adriana J. Gutierrez Ramirez, Kelsey Voss, Maya S. Ryan, Azam Gholizadeh, Jeffrey C. Rathmell, and Paul Abbyad. “Droplet Microfluidic Technology for the Early and Label-Free Isolation of Highly-Glycolytic, Activated T-Cells.” Micromachines (Basel) 13, no. 9 (September 1, 2022). https://doi.org/10.3390/mi13091442.
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  - Chen, Zhenghao, Helga Simon-Molas, Gaspard Cretenet, Beatriz Valle-Argos, Lindsay D. Smith, Francesco Forconi, Bauke V. Schomakers, et al. “Characterization of metabolic alterations of chronic lymphocytic leukemia in the lymph node microenvironment.” Blood 140, no. 6 (August 11, 2022): 630–43. https://doi.org/10.1182/blood.2021013990.
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  - Kaviany, Saara, Todd Bartkowiak, Daniel E. Dulek, Yasmin W. Khan, Madeline J. Hayes, Samuel G. Schaefer, Xiang Ye, et al. “Systems Immunology Analyses of STAT1 Gain-of-Function Immune Phenotypes Reveal Heterogeneous Response to IL-6 and Broad Immunometabolic Roles for STAT1.” Immunohorizons 6, no. 7 (July 15, 2022): 447–64. https://doi.org/10.4049/immunohorizons.2200041.
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  - Thangavelu, Govindarajan, Gabriela Andrejeva, Sara Bolivar-Wagers, Sujeong Jin, Michael C. Zaiken, Michael Loschi, Ethan G. Aguilar, et al. “Retinoic acid signaling acts as a rheostat to balance Treg function.” Cell Mol Immunol 19, no. 7 (July 2022): 820–33. https://doi.org/10.1038/s41423-022-00869-y.
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  - Kramer, Kevin J., Erin M. Wilfong, Kelsey Voss, Sierra M. Barone, Andrea R. Shiakolas, Nagarajan Raju, Caroline E. Roe, et al. “Single-cell profiling of the antigen-specific response to BNT162b2 SARS-CoV-2 RNA vaccine.” Nat Commun 13, no. 1 (June 16, 2022): 3466. https://doi.org/10.1038/s41467-022-31142-5.
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  - Khandekar, Durga, Debolanle O. Dahunsi, Isaac V. Manzanera Esteve, Sonya Reid, Jeffrey C. Rathmell, Jens Titze, and Venkataswarup Tiriveedhi. “Low-Salt Diet Reduces Anti-CTLA4 Mediated Systemic Immune-Related Adverse Events while Retaining Therapeutic Efficacy against Breast Cancer.” Biology (Basel) 11, no. 6 (May 25, 2022). https://doi.org/10.3390/biology11060810.
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  - Glass, Evan B., Alyssa A. Hoover, Kennady K. Bullock, Matthew Z. Madden, Bradley I. Reinfeld, Whitney Harris, Dominique Parker, et al. “Stimulating TAM-mediated anti-tumor immunity with mannose-decorated nanoparticles in ovarian cancer.” Bmc Cancer 22, no. 1 (May 6, 2022): 497. https://doi.org/10.1186/s12885-022-09612-2.
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  - Heintzman, Darren R., Emilie L. Fisher, and Jeffrey C. Rathmell. “Microenvironmental influences on T cell immunity in cancer and inflammation.” Cell Mol Immunol 19, no. 3 (March 2022): 316–26. https://doi.org/10.1038/s41423-021-00833-2.
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  - Monteith, Andrew J., Jeanette M. Miller, Jonathan M. Williams, Kelsey Voss, Jeffrey C. Rathmell, Leslie J. Crofford, and Eric P. Skaar. “Altered Mitochondrial Homeostasis during Systemic Lupus Erythematosus Impairs Neutrophil Extracellular Trap Formation Rendering Neutrophils Ineffective at Combating Staphylococcus aureus.” J Immunol 208, no. 2 (January 15, 2022): 454–63. https://doi.org/10.4049/jimmunol.2100752.
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  - Sugiura, Ayaka, Gabriela Andrejeva, Kelsey Voss, Darren R. Heintzman, Xincheng Xu, Matthew Z. Madden, Xiang Ye, et al. “MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function.” Immunity 55, no. 1 (January 11, 2022): 65-81.e9. https://doi.org/10.1016/j.immuni.2021.10.011.
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  - Baechle, Jordan J., David N. Hanna, Konjeti R. Sekhar, Jeffrey C. Rathmell, Wendy Kimryn Rathmell, and Naira Baregamian. “Multiplatform computational analysis of mast cells in adrenocortical carcinoma tumor microenvironment.” Surgery 171, no. 1 (January 2022): 111–18. https://doi.org/10.1016/j.surg.2021.04.045.
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  - Huang, Ying, Yujing Zou, Yiqun Jiao, Peijie Shi, Xiaoli Nie, Wei Huang, Chuanfeng Xiong, et al. “Targeting Glycolysis in Alloreactive T Cells to Prevent Acute Graft-Versus-Host Disease While Preserving Graft-Versus-Leukemia Effect.” Front Immunol 13 (2022): 751296. https://doi.org/10.3389/fimmu.2022.751296.
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  - Peek, Christopher T., Caleb A. Ford, Kara R. Eichelberger, Justin Jacobse, Teresa P. Torres, Damian Maseda, Yvonne L. Latour, et al. “Intestinal Inflammation Promotes MDL-1+ Osteoclast Precursor Expansion to Trigger Osteoclastogenesis and Bone Loss.” Cell Mol Gastroenterol Hepatol 14, no. 4 (2022): 731–50. https://doi.org/10.1016/j.jcmgh.2022.07.002.
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  - Reinfeld, Bradley I., W Kimryn Rathmell, Tae Kon Kim, and Jeffrey C. Rathmell. “The therapeutic implications of immunosuppressive tumor aerobic glycolysis.” Cell Mol Immunol 19, no. 1 (January 2022): 46–58. https://doi.org/10.1038/s41423-021-00727-3.
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  - Dudzinski, Stephanie O., Jackie E. Bader, Kathryn E. Beckermann, Kirsten L. Young, Rachel Hongo, Matthew Z. Madden, Abin Abraham, et al. “Leptin Augments Antitumor Immunity in Obesity by Repolarizing Tumor-Associated Macrophages.” J Immunol 207, no. 12 (December 15, 2021): 3122–30. https://doi.org/10.4049/jimmunol.2001152.
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  - Baechle, Jordan J., David N. Hanna, Konjeti R. Sekhar, Jeffrey C. Rathmell, W Kimryn Rathmell, and Naira Baregamian. “Integrative computational immunogenomic profiling of cortisol-secreting adrenocortical carcinoma.” J Cell Mol Med 25, no. 21 (November 2021): 10061–72. https://doi.org/10.1111/jcmm.16936.
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  - Hinshaw, Dominique C., Ann Hanna, Tshering Lama-Sherpa, Brandon Metge, Sarah C. Kammerud, Gloria A. Benavides, Atul Kumar, et al. “Hedgehog Signaling Regulates Metabolism and Polarization of Mammary Tumor-Associated Macrophages.” Cancer Res 81, no. 21 (November 1, 2021): 5425–37. https://doi.org/10.1158/0008-5472.CAN-20-1723.
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  - Voss, Kelsey, Hanna S. Hong, Jackie E. Bader, Ayaka Sugiura, Costas A. Lyssiotis, and Jeffrey C. Rathmell. “A guide to interrogating immunometabolism.” Nat Rev Immunol 21, no. 10 (October 2021): 637–52. https://doi.org/10.1038/s41577-021-00529-8.
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  - Yoo, Woongjae, Jacob K. Zieba, Nora J. Foegeding, Teresa P. Torres, Catherine D. Shelton, Nicolas G. Shealy, Austin J. Byndloss, et al. “High-fat diet-induced colonocyte dysfunction escalates microbiota-derived trimethylamine N-oxide.” Science 373, no. 6556 (August 13, 2021): 813–18. https://doi.org/10.1126/science.aba3683.
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  - De Melo, Paulo, Annie Rocio Pineros Alvarez, Xiang Ye, Amondrea Blackman, Jose Carlos Alves-Filho, Alexandra I. Medeiros, Jeffrey Rathmell, Heather Pua, and C Henrique Serezani. “Macrophage-Derived MicroRNA-21 Drives Overwhelming Glycolytic and Inflammatory Response during Sepsis via Repression of the PGE2/IL-10 Axis.” J Immunol 207, no. 3 (August 1, 2021): 902–12. https://doi.org/10.4049/jimmunol.2001251.
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  - Madden, Matthew Z., and Jeffrey C. Rathmell. “The Complex Integration of T-cell Metabolism and Immunotherapy.” Cancer Discov 11, no. 7 (July 2021): 1636–43. https://doi.org/10.1158/2159-8290.CD-20-0569.
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  - Jia, Wei, Jonathan C. Poe, Hsuan Su, Sarah Anand, Glenn K. Matsushima, Jeffrey C. Rathmell, Ivan Maillard, et al. “BAFF promotes heightened BCR responsiveness and manifestations of chronic GVHD after allogeneic stem cell transplantation.” Blood 137, no. 18 (May 6, 2021): 2544–57. https://doi.org/10.1182/blood.2020008040.
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  - Ancey, Pierre-Benoit, Caroline Contat, Gael Boivin, Silvia Sabatino, Justine Pascual, Nadine Zangger, Jean Yannis Perentes, et al. “GLUT1 Expression in Tumor-Associated Neutrophils Promotes Lung Cancer Growth and Resistance to Radiotherapy.” Cancer Res 81, no. 9 (May 1, 2021): 2345–57. https://doi.org/10.1158/0008-5472.CAN-20-2870.
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  - Reinfeld, Bradley I., Matthew Z. Madden, Melissa M. Wolf, Anna Chytil, Jackie E. Bader, Andrew R. Patterson, Ayaka Sugiura, et al. “Cell-programmed nutrient partitioning in the tumour microenvironment.” Nature 593, no. 7858 (May 2021): 282–88. https://doi.org/10.1038/s41586-021-03442-1.
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  - Levine, Lauren S., Kamir J. Hiam-Galvez, Diana M. Marquez, Iliana Tenvooren, Matthew Z. Madden, Diana C. Contreras, Debolanle O. Dahunsi, et al. “Single-cell analysis by mass cytometry reveals metabolic states of early-activated CD8+ T cells during the primary immune response.” Immunity 54, no. 4 (April 13, 2021): 829-844.e5. https://doi.org/10.1016/j.immuni.2021.02.018.
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  - Tiriveedhi, Venkataswarup, Michael T. Ivy, Elbert L. Myles, Roy Zent, Jeffrey C. Rathmell, and Jens Titze. “Ex Vivo High Salt Activated Tumor-Primed CD4+T Lymphocytes Exert a Potent Anti-Cancer Response.” Cancers 13, no. 7 (April 2021): 1690. https://doi.org/10.3390/cancers13071690.
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  - Rathmell, Jeffrey C. “Obesity, Immunity, and Cancer.” N Engl J Med 384, no. 12 (March 25, 2021): 1160–62. https://doi.org/10.1056/NEJMcibr2035081.
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  - Shiuan, Eileen, Anupama Reddy, Stephanie O. Dudzinski, Aaron R. Lim, Ayaka Sugiura, Rachel Hongo, Kirsten Young, et al. “Clinical Features and Multiplatform Molecular Analysis Assist in Understanding Patient Response to Anti-PD-1/PD-L1 in Renal Cell Carcinoma.” Cancers (Basel) 13, no. 6 (March 23, 2021). https://doi.org/10.3390/cancers13061475.
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  - Healey, Diana C Contreras, Jacqueline Y. Cephus, Sierra M. Barone, Nowrin U. Chowdhury, Debolanle O. Dahunsi, Matthew Z. Madden, Xiang Ye, et al. “Targeting In Vivo Metabolic Vulnerabilities of Th2 and Th17 Cells Reduces Airway Inflammation.” J Immunol 206, no. 6 (March 15, 2021): 1127–39. https://doi.org/10.4049/jimmunol.2001029.
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  - Edwards, Deanna N., Verra M. Ngwa, Ariel L. Raybuck, Shan Wang, Yoonha Hwang, Laura C. Kim, Sung Hoon Cho, et al. “Selective glutamine metabolism inhibition in tumor cells improves antitumor T lymphocyte activity in triple-negative breast cancer.” The Journal of Clinical Investigation 131, no. 4 (February 2021): 140100. https://doi.org/10.1172/jci140100.
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  - Rathmell, Jeffrey C., and W Kimryn Rathmell. “Pushing the boundaries with collision collaboration: the marriage of ideas.” J Clin Invest 131, no. 2 (January 19, 2021). https://doi.org/10.1172/JCI145964.
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  - Ramsey, Haley E., Dalton Greenwood, Susu Zhang, Merrida Childress, Maria P. Arrate, Agnieszka E. Gorska, Londa Fuller, et al. “BET Inhibition Enhances the Antileukemic Activity of Low-dose Venetoclax in Acute Myeloid Leukemia.” Clin Cancer Res 27, no. 2 (January 15, 2021): 598–607. https://doi.org/10.1158/1078-0432.CCR-20-1346.
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  - Mohamed, Fathima A., Govindarajan Thangavelu, Stephanie Y. Rhee, Peter T. Sage, Roddy S. O’Connor, Jeffrey C. Rathmell, and Bruce R. Blazar. “Recent Metabolic Advances for Preventing and Treating Acute and Chronic Graft Versus Host Disease.” Frontiers in Immunology 12 (January 2021): 757836. https://doi.org/10.3389/fimmu.2021.757836.
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  - Wu, Hera, DeVon Herr, Nancie J. MacIver, Jeffrey C. Rathmell, and Valerie A. Gerriets. “CD4 T cells differentially express cellular machinery for serotonin signaling, synthesis, and metabolism.” Int Immunopharmacol 88 (November 2020): 106922. https://doi.org/10.1016/j.intimp.2020.106922.
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  - Beckermann, Kathryn E., Rachel Hongo, Xiang Ye, Kirsten Young, Katie Carbonell, Diana C Contreras Healey, Peter J. Siska, et al. “CD28 costimulation drives tumor-infiltrating T cell glycolysis to promote inflammation.” Jci Insight 5, no. 16 (August 20, 2020). https://doi.org/10.1172/jci.insight.138729.
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  - Contat, Caroline, Pierre-Benoit Ancey, Nadine Zangger, Silvia Sabatino, Justine Pascual, Stéphane Escrig, Louise Jensen, et al. “Combined deletion of Glut1 and Glut3 impairs lung adenocarcinoma growth.” Elife 9 (June 23, 2020). https://doi.org/10.7554/eLife.53618.
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  - Bader, Jackie E., Kelsey Voss, and Jeffrey C. Rathmell. “Targeting Metabolism to Improve the Tumor Microenvironment for Cancer Immunotherapy.” Mol Cell 78, no. 6 (June 18, 2020): 1019–33. https://doi.org/10.1016/j.molcel.2020.05.034.
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  - Jiang, Xiaoyu, Stephanie Dudzinski, Kathryn E. Beckermann, Kirsten Young, Eliot McKinley, Oliver J McIntyre, Jeffrey C. Rathmell, Junzhong Xu, and John C. Gore. “MRI of tumor T cell infiltration in response to checkpoint inhibitor therapy.” J Immunother Cancer 8, no. 1 (June 2020). https://doi.org/10.1136/jitc-2019-000328.
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  - Raddatz, Michael A., Tessa Huffstater, Matthew R. Bersi, Bradley I. Reinfeld, Matthew Z. Madden, Sabrina E. Booton, W Kimryn Rathmell, et al. “Macrophages Promote Aortic Valve Cell Calcification and Alter STAT3 Splicing.” Arterioscler Thromb Vasc Biol 40, no. 6 (June 2020): e153–65. https://doi.org/10.1161/ATVBAHA.120.314360.
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  - Lim, Aaron R., W Kimryn Rathmell, and Jeffrey C. Rathmell. “The tumor microenvironment as a metabolic barrier to effector T cells and immunotherapy.” Elife 9 (May 2020): e55185. https://doi.org/10.7554/elife.55185.
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  - Makowski, Liza, Mehdi Chaib, and Jeffrey C. Rathmell. “Immunometabolism: From basic mechanisms to translation.” Immunol Rev 295, no. 1 (May 2020): 5–14. https://doi.org/10.1111/imr.12858.
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  - Li, Chaofan, Bibo Zhu, Young Min Son, Zheng Wang, Li Jiang, Min Xiang, Zhenqing Ye, et al. “The Transcription Factor Bhlhe40 Programs Mitochondrial Regulation of Resident CD8+ T Cell Fitness and Functionality.” Immunity 52, no. 1 (January 14, 2020): 201–2. https://doi.org/10.1016/j.immuni.2019.12.008.
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  - Li, Chaofan, Bibo Zhu, Young Min Son, Zheng Wang, Li Jiang, Min Xiang, Zhenqing Ye, et al. “The Transcription Factor Bhlhe40 Programs Mitochondrial Regulation of Resident CD8+ T Cell Fitness and Functionality.” Immunity 51, no. 3 (September 17, 2019): 491-507.e7. https://doi.org/10.1016/j.immuni.2019.08.013.
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  - Dudzinski, Stephanie O., Brent D. Cameron, Jian Wang, Jeffrey C. Rathmell, Todd D. Giorgio, and Austin N. Kirschner. “Combination immunotherapy and radiotherapy causes an abscopal treatment response in a mouse model of castration resistant prostate cancer.” J Immunother Cancer 7, no. 1 (August 14, 2019): 218. https://doi.org/10.1186/s40425-019-0704-z.
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  - Bruggen, Jaco A. C. van, Anne W. J. Martens, Joseph A. Fraietta, Tom Hofland, Sanne H. Tonino, Eric Eldering, Mark-David Levin, et al. “Chronic lymphocytic leukemia cells impair mitochondrial fitness in CD8+ T cells and impede CAR T-cell efficacy.” Blood 134, no. 1 (July 4, 2019): 44–58. https://doi.org/10.1182/blood.2018885863.
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  - Savona, Michael R., and Jeffrey C. Rathmell. “Mitochondrial Homeostasis in AML and Gasping for Response in Resistance to BCL2 Blockade.” Cancer Discov 9, no. 7 (July 2019): 831–33. https://doi.org/10.1158/2159-8290.CD-19-0510.
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  - Babaer, Duaa, Suneetha Amara, Brenda S. McAdory, Owen Johnson, Elbert L. Myles, Roy Zent, Jeffrey C. Rathmell, and Venkataswarup Tiriveedhi. “Oligodeoxynucleotides ODN 2006 and M362 Exert Potent Adjuvant Effect through TLR-9/-6 Synergy to Exaggerate Mammaglobin-A Peptide Specific Cytotoxic CD8+T Lymphocyte Responses against Breast Cancer Cells.” Cancers (Basel) 11, no. 5 (May 14, 2019). https://doi.org/10.3390/cancers11050672.
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  - Sinclair, Linda V., Andrew Jm Howden, Alejandro Brenes, Laura Spinelli, Jens L. Hukelmann, Andrew N. Macintyre, Xiaojing Liu, et al. “Antigen receptor control of methionine metabolism in T cells.” Elife 8 (March 27, 2019). https://doi.org/10.7554/eLife.44210.
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  - Freemerman, Alex J., Liyang Zhao, Ajeeth K. Pingili, Bin Teng, Alyssa J. Cozzo, Ashley M. Fuller, Amy R. Johnson, et al. “Myeloid Slc2a1-Deficient Murine Model Revealed Macrophage Activation and Metabolic Phenotype Are Fueled by GLUT1.” J Immunol 202, no. 4 (February 15, 2019): 1265–86. https://doi.org/10.4049/jimmunol.1800002.
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  - Chatterjee, Shilpak, Paramita Chakraborty, Anusara Daenthanasanmak, Supinya Iamsawat, Gabriela Andrejeva, Libia A. Luevano, Melissa Wolf, et al. “Targeting PIM Kinase with PD1 Inhibition Improves Immunotherapeutic Antitumor T-cell Response.” Clin Cancer Res 25, no. 3 (February 1, 2019): 1036–49. https://doi.org/10.1158/1078-0432.CCR-18-0706.
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  - Gemta, Lelisa F., Peter J. Siska, Marin E. Nelson, Xia Gao, Xiaojing Liu, Jason W. Locasale, Hideo Yagita, et al. “Impaired enolase 1 glycolytic activity restrains effector functions of tumor-infiltrating CD8+ T cells.” Sci Immunol 4, no. 31 (January 25, 2019). https://doi.org/10.1126/sciimmunol.aap9520.
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  - Greenplate, Allison R., Daniel D. McClanahan, Brian K. Oberholtzer, Deon B. Doxie, Caroline E. Roe, Kirsten E. Diggins, Nalin Leelatian, et al. “Computational Immune Monitoring Reveals Abnormal Double-Negative T Cells Present across Human Tumor Types.” Cancer Immunol Res 7, no. 1 (January 2019): 86–99. https://doi.org/10.1158/2326-6066.CIR-17-0692.
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  - Fuseini, Hubaida, Jacqueline-Yvonne Cephus, Pingsheng Wu, J Brooke Davis, Diana C. Contreras, Vivek D. Gandhi, Jeffrey C. Rathmell, and Dawn C. Newcomb. “ERα Signaling Increased IL-17A Production in Th17 Cells by Upregulating IL-23R Expression, Mitochondrial Respiration, and Proliferation.” Front Immunol 10 (2019): 2740. https://doi.org/10.3389/fimmu.2019.02740.
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  - Johnson, Marc O., Melissa M. Wolf, Matthew Z. Madden, Gabriela Andrejeva, Ayaka Sugiura, Diana C. Contreras, Damian Maseda, et al. “Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism.” Cell 175, no. 7 (December 13, 2018): 1780-1795.e19. https://doi.org/10.1016/j.cell.2018.10.001.
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  - Morioka, Sho, Justin S. A. Perry, Michael H. Raymond, Christopher B. Medina, Yunlu Zhu, Liyang Zhao, Vlad Serbulea, et al. “Efferocytosis induces a novel SLC program to promote glucose uptake and lactate release.” Nature 563, no. 7733 (November 2018): 714–18. https://doi.org/10.1038/s41586-018-0735-5.
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  - Rathmell, W Kimryn, Jeffrey C. Rathmell, and W Marston Linehan. “Metabolic Pathways in Kidney Cancer: Current Therapies and Future Directions.” J Clin Oncol, October 29, 2018, JCO2018792309. https://doi.org/10.1200/JCO.2018.79.2309.
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  - Ji, Xiangming, Jun Qian, SM Jamshedur Rahman, Peter J. Siska, Yong Zou, Bradford K. Harris, Megan D. Hoeksema, et al. “xCT (SLC7A11)-mediated metabolic reprogramming promotes non-small cell lung cancer progression.” Oncogene 37, no. 36 (September 2018): 5007–19. https://doi.org/10.1038/s41388-018-0307-z.
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  - Zhang, Zhuzhen, Zhenzhen Zi, Eunice E. Lee, Jiawei Zhao, Diana C. Contreras, Andrew P. South, E Dale Abel, et al. “Differential glucose requirement in skin homeostasis and injury identifies a therapeutic target for psoriasis.” Nat Med 24, no. 5 (May 2018): 617–27. https://doi.org/10.1038/s41591-018-0003-0.
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  - Schulte, Michael L., Allie Fu, Ping Zhao, Jun Li, Ling Geng, Shannon T. Smith, Jumpei Kondo, et al. “Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models.” Nat Med 24, no. 2 (February 2018): 194–202. https://doi.org/10.1038/nm.4464.
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  - Chen, Yen-Hua, Radomir Kratchmarov, Wen-Hsuan W. Lin, Nyanza J. Rothman, Bonnie Yen, William C. Adams, Simone A. Nish, Jeffrey C. Rathmell, and Steven L. Reiner. “Asymmetric PI3K Activity in Lymphocytes Organized by a PI3K-Mediated Polarity Pathway.” Cell Rep 22, no. 4 (January 23, 2018): 860–68. https://doi.org/10.1016/j.celrep.2017.12.087.
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  - Sugiura, Ayaka, and Jeffrey C. Rathmell. “Metabolic Barriers to T Cell Function in Tumors.” J Immunol 200, no. 2 (January 15, 2018): 400–407. https://doi.org/10.4049/jimmunol.1701041.
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  - Chatterjee, Shilpak, Anusara Daenthanasanmak, Paramita Chakraborty, Megan W. Wyatt, Payal Dhar, Shanmugam Panneer Selvam, Jianing Fu, et al. “CD38-NAD+Axis Regulates Immunotherapeutic Anti-Tumor T Cell Response.” Cell Metab 27, no. 1 (January 9, 2018): 85-100.e8. https://doi.org/10.1016/j.cmet.2017.10.006.
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  - Zhang, Qin, Dennis K. Jeppesen, James N. Higginbotham, Michelle Demory Beckler, Emily J. Poulin, Alex J. Walsh, Melissa C. Skala, et al. “Mutant KRAS Exosomes Alter the Metabolic State of Recipient Colonic Epithelial Cells.” Cell Mol Gastroenterol Hepatol 5, no. 4 (2018): 627-629.e6. https://doi.org/10.1016/j.jcmgh.2018.01.013.
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  - Afzal, J., A. Chan, M. F. Karakas, K. Woldemichael, S. Vakrou, Y. Guan, J. Rathmell, et al. “Cardiosphere-Derived Cells Demonstrate Metabolic Flexibility That Is Influenced by Adhesion Status.” Jacc: Basic to Translational Science 2, no. 5 (October 1, 2017): 543–60. https://doi.org/10.1016/j.jacbts.2017.03.016.
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  - Lee, Kyung-Min, Jennifer M. Giltnane, Justin M. Balko, Luis J. Schwarz, Angel L. Guerrero-Zotano, Katherine E. Hutchinson, Mellissa J. Nixon, et al. “MYC and MCL1 Cooperatively Promote Chemotherapy-Resistant Breast Cancer Stem Cells via Regulation of Mitochondrial Oxidative Phosphorylation.” Cell Metabolism 26, no. 4 (October 2017): 633-647.e7. https://doi.org/10.1016/j.cmet.2017.09.009.
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  - Liberti, Maria V., Ziwei Dai, Suzanne E. Wardell, Joshua A. Baccile, Xiaojing Liu, Xia Gao, Robert Baldi, et al. “A Predictive Model for Selective Targeting of the Warburg Effect through GAPDH Inhibition with a Natural Product.” Cell Metabolism 26, no. 4 (October 2017): 648-659.e8. https://doi.org/10.1016/j.cmet.2017.08.017.
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  - Andrejeva, Gabriela, and Jeffrey C. Rathmell. “Similarities and Distinctions of Cancer and Immune Metabolism in Inflammation and Tumors.” Cell Metab 26, no. 1 (July 5, 2017): 49–70. https://doi.org/10.1016/j.cmet.2017.06.004.
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  - Siska, Peter J., Kathryn E. Beckermann, Frank M. Mason, Gabriela Andrejeva, Allison R. Greenplate, Adam B. Sendor, Yun-Chen J. Chiang, et al. “Mitochondrial dysregulation and glycolytic insufficiency functionally impair CD8 T cells infiltrating human renal cell carcinoma.” Jci Insight 2, no. 12 (June 15, 2017). https://doi.org/10.1172/jci.insight.93411.
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  - MacIver, Nancie J., and Jeffrey C. Rathmell. “Editorial overview: Metabolism of T cells: integrating nutrients, signals, and cell fate.” Curr Opin Immunol 46 (June 2017): viii–xi. https://doi.org/10.1016/j.coi.2017.06.002.
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  - Beckermann, Kathryn E., Stephanie O. Dudzinski, and Jeffrey C. Rathmell. “Dysfunctional T cell metabolism in the tumor microenvironment.” Cytokine Growth Factor Rev 35 (June 2017): 7–14. https://doi.org/10.1016/j.cytogfr.2017.04.003.
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  - Olenchock, Benjamin A., Jeffrey C. Rathmell, and Matthew G. Vander Heiden. “Biochemical Underpinnings of Immune Cell Metabolic Phenotypes.” Immunity 46, no. 5 (May 16, 2017): 703–13. https://doi.org/10.1016/j.immuni.2017.04.013.
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  - Rhoads, Jillian P., Amy S. Major, and Jeffrey C. Rathmell. “Fine tuning of immunometabolism for the treatment of rheumatic diseases.” Nat Rev Rheumatol 13, no. 5 (May 2017): 313–20. https://doi.org/10.1038/nrrheum.2017.54.
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  - Schmidt, Elyse A., Brian E. Fee, Stanley C. Henry, Amanda G. Nichols, Mari L. Shinohara, Jeffrey C. Rathmell, Nancie J. MacIver, et al. “Metabolic Alterations Contribute to Enhanced Inflammatory Cytokine Production in Irgm1-deficient Macrophages.” J Biol Chem 292, no. 11 (March 17, 2017): 4651–62. https://doi.org/10.1074/jbc.M116.770735.
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  - Siska, Peter J., Romany A. N. Johnpulle, Alice Zhou, Jennifer Bordeaux, Ju Young Kim, Bashar Dabbas, Naveen Dakappagari, et al. “Deep exploration of the immune infiltrate and outcome prediction in testicular cancer by quantitative multiplexed immunohistochemistry and gene expression profiling.” Oncoimmunology 6, no. 4 (2017): e1305535. https://doi.org/10.1080/2162402X.2017.1305535.
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  - Adams, William C., Yen-Hua Chen, Radomir Kratchmarov, Bonnie Yen, Simone A. Nish, Wen-Hsuan W. Lin, Nyanza J. Rothman, et al. “Anabolism-Associated Mitochondrial Stasis Driving Lymphocyte Differentiation over Self-Renewal.” Cell Rep 17, no. 12 (December 20, 2016): 3142–52. https://doi.org/10.1016/j.celrep.2016.11.065.
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  - Gerriets, Valerie A., Rigel J. Kishton, Marc O. Johnson, Sivan Cohen, Peter J. Siska, Amanda G. Nichols, Marc O. Warmoes, et al. “Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression.” Nat Immunol 17, no. 12 (December 2016): 1459–66. https://doi.org/10.1038/ni.3577.
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  - Siska, Peter J., and Jeffrey C. Rathmell. “Metabolic Signaling Drives IFN-γ.” Cell Metab 24, no. 5 (November 8, 2016): 651–52. https://doi.org/10.1016/j.cmet.2016.10.018.
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  - Siska, Peter J., Bumki Kim, Xiangming Ji, Megan D. Hoeksema, Pierre P. Massion, Kathryn E. Beckermann, Jianli Wu, Jen-Tsan Chi, Jiyong Hong, and Jeffrey C. Rathmell. “Fluorescence-based measurement of cystine uptake through xCT shows requirement for ROS detoxification in activated lymphocytes.” J Immunol Methods 438 (November 2016): 51–58. https://doi.org/10.1016/j.jim.2016.08.013.
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  - Johnson, Marc O., Peter J. Siska, Diana C. Contreras, and Jeffrey C. Rathmell. “Nutrients and the microenvironment to feed a T cell army.” Semin Immunol 28, no. 5 (October 2016): 505–13. https://doi.org/10.1016/j.smim.2016.09.003.
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  - Zeng, Hu, Sivan Cohen, Cliff Guy, Sharad Shrestha, Geoffrey Neale, Scott A. Brown, Caryn Cloer, et al. “mTORC1 and mTORC2 Kinase Signaling and Glucose Metabolism Drive Follicular Helper T Cell Differentiation.” Immunity 45, no. 3 (September 20, 2016): 540–54. https://doi.org/10.1016/j.immuni.2016.08.017.
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  - Siska, Peter J., Gerritje J. W. van der Windt, Rigel J. Kishton, Sivan Cohen, William Eisner, Nancie J. MacIver, Arnon P. Kater, J Brice Weinberg, and Jeffrey C. Rathmell. “Suppression of Glut1 and Glucose Metabolism by Decreased Akt/mTORC1 Signaling Drives T Cell Impairment in B Cell Leukemia.” J Immunol 197, no. 6 (September 15, 2016): 2532–40. https://doi.org/10.4049/jimmunol.1502464.
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  - O’Neill, Luke A. J., Rigel J. Kishton, and Jeff Rathmell. “A guide to immunometabolism for immunologists.” Nat Rev Immunol 16, no. 9 (September 2016): 553–65. https://doi.org/10.1038/nri.2016.70.
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  - Kishton, Rigel J., Carson E. Barnes, Amanda G. Nichols, Sivan Cohen, Valerie A. Gerriets, Peter J. Siska, Andrew N. Macintyre, et al. “AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival.” Cell Metab 23, no. 4 (April 12, 2016): 649–62. https://doi.org/10.1016/j.cmet.2016.03.008.
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  - Park, Sunghee, Ching-Yi Chang, Rachid Safi, Xiaojing Liu, Robert Baldi, Jeff S. Jasper, Grace R. Anderson, et al. “ERRα-Regulated Lactate Metabolism Contributes to Resistance to Targeted Therapies in Breast Cancer.” Cell Rep 15, no. 2 (April 12, 2016): 323–35. https://doi.org/10.1016/j.celrep.2016.03.026.
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  - Hosios, Aaron M., Vivian C. Hecht, Laura V. Danai, Marc O. Johnson, Jeffrey C. Rathmell, Matthew L. Steinhauser, Scott R. Manalis, and Matthew G. Vander Heiden. “Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells.” Dev Cell 36, no. 5 (March 7, 2016): 540–49. https://doi.org/10.1016/j.devcel.2016.02.012.
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  - McFadden, Karyn, Amy Y. Hafez, Rigel Kishton, Joshua E. Messinger, Pavel A. Nikitin, Jeffrey C. Rathmell, and Micah A. Luftig. “Metabolic stress is a barrier to Epstein-Barr virus-mediated B-cell immortalization.” Proc Natl Acad Sci U S A 113, no. 6 (February 9, 2016): E782–90. https://doi.org/10.1073/pnas.1517141113.
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  - Johnson, Marc O., and Jeffrey C. Rathmell. “AIF Is "Always In Fashion" for T Cells.” Immunity 44, no. 1 (January 19, 2016): 11–13. https://doi.org/10.1016/j.immuni.2015.12.015.
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  - Hu, Jing, Tao Sun, Hui Wang, Zhengxin Chen, Shuai Wang, Lifeng Yuan, Tingyu Liu, et al. “MiR-215 Is Induced Post-transcriptionally via HIF-Drosha Complex and Mediates Glioma-Initiating Cell Adaptation to Hypoxia by Targeting KDM1B.” Cancer Cell 29, no. 1 (January 11, 2016): 49–60. https://doi.org/10.1016/j.ccell.2015.12.005.
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  - Kang, SunAh, Amanda B. Keener, Shannon Z. Jones, Robert J. Benschop, Alfredo Caro-Maldonado, Jeffrey C. Rathmell, Stephen H. Clarke, Glenn K. Matsushima, Jason K. Whitmire, and Barbara J. Vilen. “IgG-Immune Complexes Promote B Cell Memory by Inducing BAFF.” J Immunol 196, no. 1 (January 1, 2016): 196–206. https://doi.org/10.4049/jimmunol.1402527.
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  - Altman, Brian J., Annie L. Hsieh, Arjun Sengupta, Saikumari Y. Krishnanaiah, Zachary E. Stine, Zandra E. Walton, Arvin M. Gouw, et al. “MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells.” Cell Metab 22, no. 6 (December 1, 2015): 1009–19. https://doi.org/10.1016/j.cmet.2015.09.003.
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  - Block, Keith I., Charlotte Gyllenhaal, Leroy Lowe, Amedeo Amedei, ARM Ruhul Amin, Amr Amin, Katia Aquilano, et al. “Designing a broad-spectrum integrative approach for cancer prevention and treatment.” Semin Cancer Biol 35 Suppl, no. Suppl (December 2015): S276–304. https://doi.org/10.1016/j.semcancer.2015.09.007.
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  - Hirschey, Matthew D., Ralph J. DeBerardinis, Anna Mae E. Diehl, Janice E. Drew, Christian Frezza, Michelle F. Green, Lee W. Jones, et al. “Dysregulated metabolism contributes to oncogenesis.” Semin Cancer Biol 35 Suppl (December 2015): S129–50. https://doi.org/10.1016/j.semcancer.2015.10.002.
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  - Ho, Ping-Chih, Jessica Dauz Bihuniak, Andrew N. Macintyre, Matthew Staron, Xiaojing Liu, Robert Amezquita, Yao-Chen Tsui, et al. “Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses.” Cell 162, no. 6 (September 10, 2015): 1217–28. https://doi.org/10.1016/j.cell.2015.08.012.
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  - Murray, Peter J., Jeffrey Rathmell, and Edward Pearce. “SnapShot: Immunometabolism.” Cell Metab 22, no. 1 (July 7, 2015): 190-190.e1. https://doi.org/10.1016/j.cmet.2015.06.014.
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  - Siska, Peter J., and Jeffrey C. Rathmell. “PKCs Sweeten Cell Metabolism by Phosphorylation of Glut1.” Mol Cell 58, no. 5 (June 4, 2015): 711–12. https://doi.org/10.1016/j.molcel.2015.05.025.
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  - Zhang, Minsi, Qiong Qiu, Zhizhong Li, Mohit Sachdeva, Hooney Min, Diana M. Cardona, Thomas F. DeLaney, et al. “HIF-1 Alpha Regulates the Response of Primary Sarcomas to Radiation Therapy through a Cell Autonomous Mechanism.” Radiat Res 183, no. 6 (June 2015): 594–609. https://doi.org/10.1667/RR14016.1.
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  - Siska, Peter J., and Jeffrey C. Rathmell. “T cell metabolic fitness in antitumor immunity.” Trends Immunol 36, no. 4 (April 2015): 257–64. https://doi.org/10.1016/j.it.2015.02.007.
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  - Kountikov, Evgueni I., Jonathan C. Poe, Nancie J. Maclver, Jeffrey C. Rathmell, and Thomas F. Tedder. “A spontaneous deletion within the desmoglein 3 extracellular domain of mice results in hypomorphic protein expression, immunodeficiency, and a wasting disease phenotype.” Am J Pathol 185, no. 3 (March 2015): 617–30. https://doi.org/10.1016/j.ajpath.2014.10.025.
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  - Huynh, Alexandria, Michel DuPage, Bhavana Priyadharshini, Peter T. Sage, Jason Quiros, Christopher M. Borges, Natavudh Townamchai, et al. “Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability.” Nat Immunol 16, no. 2 (February 2015): 188–96. https://doi.org/10.1038/ni.3077.
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  - Gerriets, Valerie A., Rigel J. Kishton, Amanda G. Nichols, Andrew N. Macintyre, Makoto Inoue, Olga Ilkayeva, Peter S. Winter, et al. “Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation.” J Clin Invest 125, no. 1 (January 2015): 194–207. https://doi.org/10.1172/JCI76012.
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  - Kishton, Rigel J., and Jeffrey C. Rathmell. “Novel therapeutic targets of tumor metabolism.” Cancer J 21, no. 2 (2015): 62–69. https://doi.org/10.1097/PPO.0000000000000099.
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  - Stathem, Morgan, Subathra Marimuthu, Julie O’Neal, Jeffrey C. Rathmell, Jason A. Chesney, Levi J. Beverly, and Leah J. Siskind. “Glucose availability and glycolytic metabolism dictate glycosphingolipid levels.” J Cell Biochem 116, no. 1 (January 2015): 67–80. https://doi.org/10.1002/jcb.24943.
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  - Martz, Colin A., Kathleen A. Ottina, Katherine R. Singleton, Jeff S. Jasper, Suzanne E. Wardell, Ashley Peraza-Penton, Gray R. Anderson, et al. “Systematic identification of signaling pathways with potential to confer anticancer drug resistance.” Sci Signal 7, no. 357 (December 23, 2014): ra121. https://doi.org/10.1126/scisignal.aaa1877.
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  - Wang, Bin, Ting-Yu Liu, Chun-Hsiang Lai, Yan-hua Rao, Moon-Chang Choi, Jen-Tsan Chi, Jian-wu Dai, Jeffrey C. Rathmell, and Tso-Pang Yao. “Glycolysis-dependent histone deacetylase 4 degradation regulates inflammatory cytokine production.” Mol Biol Cell 25, no. 21 (November 1, 2014): 3300–3307. https://doi.org/10.1091/mbc.E13-12-0757.
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  - Liu, T., R. J. Kishton, A. N. Macintyre, V. A. Gerriets, H. Xiang, X. Liu, E. D. Abel, D. Rizzieri, J. W. Locasale, and J. C. Rathmell. “Glucose transporter 1-mediated glucose uptake is limiting for B-cell acute lymphoblastic leukemia anabolic metabolism and resistance to apoptosis.” Cell Death Dis 5, no. 10 (October 16, 2014): e1470. https://doi.org/10.1038/cddis.2014.431.
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  - Kim, Jiyeon S., Tammarah Sklarz, Lauren B. Banks, Mercy Gohil, Adam T. Waickman, Nicolas Skuli, Bryan L. Krock, et al. “Retraction: Natural and inducible TH17 cells are regulated differently by Akt and mTOR pathways.” Nat Immunol 15, no. 10 (October 2014): 996. https://doi.org/10.1038/ni0910-996.
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  - Macintyre, Andrew N., Valerie A. Gerriets, Amanda G. Nichols, Ryan D. Michalek, Michael C. Rudolph, Divino Deoliveira, Steven M. Anderson, et al. “The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function.” Cell Metab 20, no. 1 (July 1, 2014): 61–72. https://doi.org/10.1016/j.cmet.2014.05.004.
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  - Caro-Maldonado, Alfredo, Ruoning Wang, Amanda G. Nichols, Masayuki Kuraoka, Sandra Milasta, Lillian D. Sun, Amanda L. Gavin, et al. “Metabolic reprogramming is required for antibody production that is suppressed in anergic but exaggerated in chronically BAFF-exposed B cells.” J Immunol 192, no. 8 (April 15, 2014): 3626–36. https://doi.org/10.4049/jimmunol.1302062.
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  - Freemerman, Alex J., Amy R. Johnson, Gina N. Sacks, J Justin Milner, Erin L. Kirk, Melissa A. Troester, Andrew N. Macintyre, Pankuri Goraksha-Hicks, Jeffery C. Rathmell, and Liza Makowski. “Metabolic reprogramming of macrophages: glucose transporter 1 (GLUT1)-mediated glucose metabolism drives a proinflammatory phenotype.” J Biol Chem 289, no. 11 (March 14, 2014): 7884–96. https://doi.org/10.1074/jbc.M113.522037.
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  - Arreola, Alexandra, C Lance Cowey, Jonathan L. Coloff, Jeffrey C. Rathmell, and W Kimryn Rathmell. “HIF1α and HIF2α exert distinct nutrient preferences in renal cells.” Plos One 9, no. 5 (2014): e98705. https://doi.org/10.1371/journal.pone.0098705.
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  - Saucillo, Donte C., Valerie A. Gerriets, John Sheng, Jeffrey C. Rathmell, and Nancie J. Maciver. “Leptin metabolically licenses T cells for activation to link nutrition and immunity.” J Immunol 192, no. 1 (January 1, 2014): 136–44. https://doi.org/10.4049/jimmunol.1301158.
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  - Cao, Yilin, Jeffrey C. Rathmell, and Andrew N. Macintyre. “Metabolic reprogramming towards aerobic glycolysis correlates with greater proliferative ability and resistance to metabolic inhibition in CD8 versus CD4 T cells.” Plos One 9, no. 8 (2014): e104104. https://doi.org/10.1371/journal.pone.0104104.
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  - Liu, T., R. J. Kishton, A. N. Macintyre, V. A. Gerriets, H. Xiang, X. Liu, E. D. Abel, D. Rizzieri, J. W. Locasale, and J. C. Rathmell. “Glucose transporter 1-mediated glucose uptake is limiting for B-cell acute lymphoblastic leukemia anabolic metabolism and resistance to apoptosis.” Cell Death Dis 5 (2014): e1516. https://doi.org/10.1038/cddis.2014.493.
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  - Green, Douglas R., and Jeffrey Rathmell. “Sweet nothings: sensing of sugar metabolites controls T cell function.” Cell Metab 18, no. 1 (July 2, 2013): 7–8. https://doi.org/10.1016/j.cmet.2013.06.009.
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  - Kim, Jiyeon S., Tammarah Sklarz, Lauren B. Banks, Mercy Gohil, Adam T. Waickman, Nicolas Skuli, Bryan L. Krock, et al. “Natural and inducible TH17 cells are regulated differently by Akt and mTOR pathways.” Nat Immunol 14, no. 6 (June 2013): 611–18. https://doi.org/10.1038/ni.2607.
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  - McCarthy, Susan A., R Allan Mufson, Edward J. Pearce, Jeffrey C. Rathmell, and T Kevin Howcroft. “Metabolic reprogramming of the immune response in the tumor microenvironment.” Cancer Biol Ther 14, no. 4 (April 2013): 315–18. https://doi.org/10.4161/cbt.23616.
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  - Kurokawa, Manabu, Takahiro Ito, Chih-Sheng Yang, Chen Zhao, Andrew N. Macintyre, David A. Rizzieri, Jeffrey C. Rathmell, Michael W. Deininger, Tannishtha Reya, and Sally Kornbluth. “Engineering a BCR-ABL-activated caspase for the selective elimination of leukemic cells.” Proc Natl Acad Sci U S A 110, no. 6 (February 5, 2013): 2300–2305. https://doi.org/10.1073/pnas.1206551110.
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  - Macintyre, Andrew N., and Jeffrey C. Rathmell. “Activated lymphocytes as a metabolic model for carcinogenesis.” Cancer Metab 1, no. 1 (January 23, 2013): 5. https://doi.org/10.1186/2049-3002-1-5.
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  - Kim, J. S., T. Sklarz, L. B. Banks, M. Gohil, A. T. Waickman, N. Skuli, B. L. Krock, et al. “Natural and inducible T_H17 cells are regulated differently by Akt and mTOR pathways.” Nature Immunology 14, no. 6 (2013): 611–18. https://doi.org/10.1038/ni.2607.
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  - MacIver, Nancie J., Ryan D. Michalek, and Jeffrey C. Rathmell. “Metabolic regulation of T lymphocytes.” Annu Rev Immunol 31 (2013): 259–83. https://doi.org/10.1146/annurev-immunol-032712-095956.
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  - Caro-Maldonado, Alfredo, Valerie A. Gerriets, and Jeffrey C. Rathmell. “Matched and mismatched metabolic fuels in lymphocyte function.” Semin Immunol 24, no. 6 (December 2012): 405–13. https://doi.org/10.1016/j.smim.2012.12.002.
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  - Altman, B. J., and J. C. Rathmell. “Metabolic stress in autophagy and cell death pathways.” Cold Spring Harbor Perspectives in Biology 4, no. 9 (September 1, 2012).
  - Altman, Brian J., and Jeffrey C. Rathmell. “Metabolic stress in autophagy and cell death pathways.” Cold Spring Harb Perspect Biol 4, no. 9 (September 1, 2012): a008763. https://doi.org/10.1101/cshperspect.a008763.
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  - Rathmell, Jeffrey C. “Metabolism and autophagy in the immune system: immunometabolism comes of age.” Immunol Rev 249, no. 1 (September 2012): 5–13. https://doi.org/10.1111/j.1600-065X.2012.01158.x.
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  - Bhatt, Aadra P., Sarah R. Jacobs, Alex J. Freemerman, Liza Makowski, Jeffrey C. Rathmell, Dirk P. Dittmer, and Blossom Damania. “Dysregulation of fatty acid synthesis and glycolysis in non-Hodgkin lymphoma.” Proc Natl Acad Sci U S A 109, no. 29 (July 17, 2012): 11818–23. https://doi.org/10.1073/pnas.1205995109.
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  - Gerriets, Valerie A., and Jeffrey C. Rathmell. “Metabolic pathways in T cell fate and function.” Trends Immunol 33, no. 4 (April 2012): 168–73. https://doi.org/10.1016/j.it.2012.01.010.
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  - Klionsky, Daniel J., Fabio C. Abdalla, Hagai Abeliovich, Robert T. Abraham, Abraham Acevedo-Arozena, Khosrow Adeli, Lotta Agholme, et al. “Guidelines for the use and interpretation of assays for monitoring autophagy.” Autophagy 8, no. 4 (April 2012): 445–544. https://doi.org/10.4161/auto.19496.
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  - Rathmell, Jeffrey C. “T cell Myc-tabolism.” Immunity 35, no. 6 (December 23, 2011): 845–46. https://doi.org/10.1016/j.immuni.2011.12.001.
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  - Nelson, Erik R., Carolyn D. DuSell, Xiaojuan Wang, Matthew K. Howe, Glenda Evans, Ryan D. Michalek, Michihisa Umetani, et al. “The oxysterol, 27-hydroxycholesterol, links cholesterol metabolism to bone homeostasis through its actions on the estrogen and liver X receptors.” Endocrinology 152, no. 12 (December 2011): 4691–4705. https://doi.org/10.1210/en.2011-1298.
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  - Michalek, Ryan D., Valerie A. Gerriets, Amanda G. Nichols, Makoto Inoue, Dmitri Kazmin, Ching-Yi Chang, Mary A. Dwyer, et al. “Estrogen-related receptor-α is a metabolic regulator of effector T-cell activation and differentiation.” Proc Natl Acad Sci U S A 108, no. 45 (November 8, 2011): 18348–53. https://doi.org/10.1073/pnas.1108856108.
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  - MacIver, Nancie J., Julianna Blagih, Donte C. Saucillo, Luciana Tonelli, Takla Griss, Jeffrey C. Rathmell, and Russell G. Jones. “The liver kinase B1 is a central regulator of T cell development, activation, and metabolism.” J Immunol 187, no. 8 (October 15, 2011): 4187–98. https://doi.org/10.4049/jimmunol.1100367.
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  - Coloff, Jonathan L., Andrew N. Macintyre, Amanda G. Nichols, Tingyu Liu, Catherine A. Gallo, David R. Plas, and Jeffrey C. Rathmell. “Akt-dependent glucose metabolism promotes Mcl-1 synthesis to maintain cell survival and resistance to Bcl-2 inhibition.” Cancer Res 71, no. 15 (August 1, 2011): 5204–13. https://doi.org/10.1158/0008-5472.CAN-10-4531.
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  - Macintyre, Andrew N., and Jeffrey C. Rathmell. “PKM2 and the tricky balance of growth and energy in cancer.” Mol Cell 42, no. 6 (June 24, 2011): 713–14. https://doi.org/10.1016/j.molcel.2011.06.003.
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  - Altman, B. J., S. R. Jacobs, E. F. Mason, R. D. Michalek, A. N. MacIntyre, J. L. Coloff, O. Ilkayeva, W. Jia, Y. -. W. He, and J. C. Rathmell. “Autophagy is essential to suppress cell stress and to allow BCR-Abl-mediated leukemogenesis.” Oncogene 30, no. 16 (April 21, 2011): 1855–67. https://doi.org/10.1038/onc.2010.561.
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  - Horn, Sarah R., Michael J. Thomenius, Erika Segear Johnson, Christopher D. Freel, Judy Q. Wu, Jonathan L. Coloff, Chih-Sheng Yang, et al. “Regulation of mitochondrial morphology by APC/CCdh1-mediated control of Drp1 stability.” Mol Biol Cell 22, no. 8 (April 15, 2011): 1207–16. https://doi.org/10.1091/mbc.E10-07-0567.
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  - Wang, Xiaoli, Colins O. Eno, Brian J. Altman, Yanglong Zhu, Guoping Zhao, Kristen E. Olberding, Jeffrey C. Rathmell, and Chi Li. “ER stress modulates cellular metabolism.” Biochem J 435, no. 1 (April 1, 2011): 285–96. https://doi.org/10.1042/BJ20101864.
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  - Mason, Emily F., and Jeffrey C. Rathmell. “Cell metabolism: an essential link between cell growth and apoptosis.” Biochim Biophys Acta 1813, no. 4 (April 2011): 645–54. https://doi.org/10.1016/j.bbamcr.2010.08.011.
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  - Michalek, Ryan D., Valerie A. Gerriets, Sarah R. Jacobs, Andrew N. Macintyre, Nancie J. MacIver, Emily F. Mason, Sarah A. Sullivan, Amanda G. Nichols, and Jeffrey C. Rathmell. “Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets.” J Immunol 186, no. 6 (March 15, 2011): 3299–3303. https://doi.org/10.4049/jimmunol.1003613.
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  - Coloff, Jonathan L., Emily F. Mason, Brian J. Altman, Valerie A. Gerriets, Tingyu Liu, Amanda N. Nichols, Yuxing Zhao, et al. “Akt requires glucose metabolism to suppress puma expression and prevent apoptosis of leukemic T cells.” J Biol Chem 286, no. 7 (February 18, 2011): 5921–33. https://doi.org/10.1074/jbc.M110.179101.
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  - Mason, Emily F., Yuxing Zhao, Pankuri Goraksha-Hicks, Jonathan L. Coloff, Hugh Gannon, Stephen N. Jones, and Jeffrey C. Rathmell. “Aerobic glycolysis suppresses p53 activity to provide selective protection from apoptosis upon loss of growth signals or inhibition of BCR-Abl.” Cancer Res 70, no. 20 (October 15, 2010): 8066–76. https://doi.org/10.1158/0008-5472.CAN-10-0608.
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  - Michalek, Ryan D., and Jeffrey C. Rathmell. “The metabolic life and times of a T-cell.” Immunol Rev 236 (July 2010): 190–202. https://doi.org/10.1111/j.1600-065X.2010.00911.x.
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  - Calamito, Marco, Marisa M. Juntilla, Matthew Thomas, Daniel L. Northrup, Jeffrey Rathmell, Morris J. Birnbaum, Gary Koretzky, and David Allman. “Akt1 and Akt2 promote peripheral B-cell maturation and survival.” Blood 115, no. 20 (May 20, 2010): 4043–50. https://doi.org/10.1182/blood-2009-09-241638.
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  - Ke, Hengning, Rebecca Harris, Jonathan L. Coloff, Jane Y. Jin, Benjamin Leshin, Paula Miliani de Marval, Shiying Tao, Jeffrey C. Rathmell, Russell P. Hall, and Jennifer Y. Zhang. “The c-Jun NH2-terminal kinase 2 plays a dominant role in human epidermal neoplasia.” Cancer Res 70, no. 8 (April 15, 2010): 3080–88. https://doi.org/10.1158/0008-5472.CAN-09-2923.
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  - Jacobs, Sarah R., Ryan D. Michalek, and Jeffrey C. Rathmell. “IL-7 is essential for homeostatic control of T cell metabolism in vivo.” J Immunol 184, no. 7 (April 1, 2010): 3461–69. https://doi.org/10.4049/jimmunol.0902593.
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  - Goraksha-Hicks, Pankuri, and Jeffrey C. Rathmell. “TGF-beta: a new role for an old AktTOR.” Dev Cell 17, no. 1 (July 2009): 6–8. https://doi.org/10.1016/j.devcel.2009.07.004.
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  - Rathmell, Jeffrey C., and Christopher B. Newgard. “Biochemistry. A glucose-to-gene link.” Science 324, no. 5930 (May 22, 2009): 1021–22. https://doi.org/10.1126/science.1174665.
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  - Altman, Brian J., and Jeffrey C. Rathmell. “Autophagy: not good OR bad, but good AND bad.” Autophagy 5, no. 4 (May 2009): 569–70. https://doi.org/10.4161/auto.5.4.8254.
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  - Wardell, Suzanne E., Olga R. Ilkayeva, Heather L. Wieman, Daniel E. Frigo, Jeffrey C. Rathmell, Christopher B. Newgard, and Donald P. McDonnell. “Glucose metabolism as a target of histone deacetylase inhibitors.” Mol Endocrinol 23, no. 3 (March 2009): 388–401. https://doi.org/10.1210/me.2008-0179.
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  - Wieman, Heather L., Sarah R. Horn, Sarah R. Jacobs, Brian J. Altman, Sally Kornbluth, and Jeffrey C. Rathmell. “An essential role for the Glut1 PDZ-binding motif in growth factor regulation of Glut1 degradation and trafficking.” Biochem J 418, no. 2 (March 1, 2009): 345–67. https://doi.org/10.1042/BJ20081422.
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  - Altman, Brian J., Jessica A. Wofford, Yuxing Zhao, Jonathan L. Coloff, Emily C. Ferguson, Heather L. Wieman, Amanda E. Day, Olga Ilkayeva, and Jeffrey C. Rathmell. “Autophagy provides nutrients but can lead to Chop-dependent induction of Bim to sensitize growth factor-deprived cells to apoptosis.” Mol Biol Cell 20, no. 4 (February 2009): 1180–91. https://doi.org/10.1091/mbc.e08-08-0829.
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  - Zhao, Yuxing, Jonathan L. Coloff, Emily C. Ferguson, Sarah R. Jacobs, Kai Cui, and Jeffrey C. Rathmell. “Glucose metabolism attenuates p53 and Puma-dependent cell death upon growth factor deprivation.” J Biol Chem 283, no. 52 (December 26, 2008): 36344–53. https://doi.org/10.1074/jbc.M803580200.
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  - Michalek, Ryan D., and Jeffrey C. Rathmell. “Methed-up FOXOs can't in-Akt-ivate.” Mol Cell 32, no. 2 (October 24, 2008): 160–62. https://doi.org/10.1016/j.molcel.2008.10.006.
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  - Maciver, Nancie J., Sarah R. Jacobs, Heather L. Wieman, Jessica A. Wofford, Jonathan L. Coloff, and Jeffrey C. Rathmell. “Glucose metabolism in lymphocytes is a regulated process with significant effects on immune cell function and survival.” J Leukoc Biol 84, no. 4 (October 2008): 949–57. https://doi.org/10.1189/jlb.0108024.
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  - Ferguson, Emily C., and Jeffrey C. Rathmell. “New roles for pyruvate kinase M2: working out the Warburg effect.” Trends Biochem Sci 33, no. 8 (August 2008): 359–62. https://doi.org/10.1016/j.tibs.2008.05.006.
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  - Jacobs, Sarah R., Catherine E. Herman, Nancie J. Maciver, Jessica A. Wofford, Heather L. Wieman, Jeremy J. Hammen, and Jeffrey C. Rathmell. “Glucose uptake is limiting in T cell activation and requires CD28-mediated Akt-dependent and independent pathways.” J Immunol 180, no. 7 (April 1, 2008): 4476–86. https://doi.org/10.4049/jimmunol.180.7.4476.
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  - Wofford, Jessica A., Heather L. Wieman, Sarah R. Jacobs, Yuxing Zhao, and Jeffrey C. Rathmell. “IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T-cell survival.” Blood 111, no. 4 (February 15, 2008): 2101–11. https://doi.org/10.1182/blood-2007-06-096297.
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  - Zhao, Yuxing, Heather L. Wieman, Sarah R. Jacobs, and Jeffrey C. Rathmell. “Mechanisms and methods in glucose metabolism and cell death.” Methods Enzymol 442 (2008): 439–57. https://doi.org/10.1016/S0076-6879(08)01422-5.
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  - Juntilla, Marisa M., Jessica A. Wofford, Morris J. Birnbaum, Jeffrey C. Rathmell, and Gary A. Koretzky. “Akt1 and Akt2 are required for alphabeta thymocyte survival and differentiation.” Proc Natl Acad Sci U S A 104, no. 29 (July 17, 2007): 12105–10. https://doi.org/10.1073/pnas.0705285104.
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  - Rathmell, Jeffrey C., and Sally Kornbluth. “Filling a GAP(DH) in caspase-independent cell death.” Cell 129, no. 5 (June 1, 2007): 861–63. https://doi.org/10.1016/j.cell.2007.05.030.
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  - Zhao, Yuxing, Brian J. Altman, Jonathan L. Coloff, Catherine E. Herman, Sarah R. Jacobs, Heather L. Wieman, Jessica A. Wofford, et al. “Glycogen synthase kinase 3alpha and 3beta mediate a glucose-sensitive antiapoptotic signaling pathway to stabilize Mcl-1.” Mol Cell Biol 27, no. 12 (June 2007): 4328–39. https://doi.org/10.1128/MCB.00153-07.
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  - Wieman, Heather L., Jessica A. Wofford, and Jeffrey C. Rathmell. “Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase/Akt regulation of Glut1 activity and trafficking.” Mol Biol Cell 18, no. 4 (April 2007): 1437–46. https://doi.org/10.1091/mbc.e06-07-0593.
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  - Coloff, Jonathan L., and Jeffrey C. Rathmell. “Metabolic regulation of Akt: roles reversed.” J Cell Biol 175, no. 6 (December 18, 2006): 845–47. https://doi.org/10.1083/jcb.200610119.
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  - Boxer, Robert B., Douglas B. Stairs, Katherine D. Dugan, Kathleen L. Notarfrancesco, Carla P. Portocarrero, Blaine A. Keister, George K. Belka, et al. “Isoform-specific requirement for Akt1 in the developmental regulation of cellular metabolism during lactation.” Cell Metab 4, no. 6 (December 2006): 475–90. https://doi.org/10.1016/j.cmet.2006.10.011.
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  - Jacobs, Sarah R., and Jeffrey C. Rathmell. “Lymphocyte selection by starvation: glucose metabolism and cell death.” Trends Immunol 27, no. 1 (January 2006): 4–7. https://doi.org/10.1016/j.it.2005.11.002.
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  - Deming, Paula B., and Jeffrey C. Rathmell. “Mitochondria, cell death, and B cell tolerance.” Curr Dir Autoimmun 9 (2006): 95–119. https://doi.org/10.1159/000090774.
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  - Nutt, Leta K., Seth S. Margolis, Mette Jensen, Catherine E. Herman, William G. Dunphy, Jeffrey C. Rathmell, and Sally Kornbluth. “Metabolic regulation of oocyte cell death through the CaMKII-mediated phosphorylation of caspase-2.” Cell 123, no. 1 (October 7, 2005): 89–103. https://doi.org/10.1016/j.cell.2005.07.032.
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  - Cinalli, Ryan M., Catherine E. Herman, Brian O. Lew, Heather L. Wieman, Craig B. Thompson, and Jeffrey C. Rathmell. “T cell homeostasis requires G protein-coupled receptor-mediated access to trophic signals that promote growth and inhibit chemotaxis.” Eur J Immunol 35, no. 3 (March 2005): 786–95. https://doi.org/10.1002/eji.200425729.
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  - Bauer, Daniel E., Marian H. Harris, David R. Plas, Julian J. Lum, Peter S. Hammerman, Jeffrey C. Rathmell, James L. Riley, and Craig B. Thompson. “Cytokine stimulation of aerobic glycolysis in hematopoietic cells exceeds proliferative demand.” Faseb J 18, no. 11 (August 2004): 1303–5. https://doi.org/10.1096/fj.03-1001fje.
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  - Bensinger, Steven J., Patrick T. Walsh, Jidong Zhang, Martin Carroll, Ramon Parsons, Jeffrey C. Rathmell, Craig B. Thompson, Matthew A. Burchill, Michael A. Farrar, and Laurence A. Turka. “Distinct IL-2 receptor signaling pattern in CD4+CD25+ regulatory T cells.” J Immunol 172, no. 9 (May 1, 2004): 5287–96. https://doi.org/10.4049/jimmunol.172.9.5287.
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  - Rathmell, Jeffrey C. “B-cell homeostasis: digital survival or analog growth?” Immunol Rev 197 (February 2004): 116–28. https://doi.org/10.1111/j.0105-2896.2004.0096.x.
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  - Rathmell, Jeffrey C., Casey J. Fox, David R. Plas, Peter S. Hammerman, Ryan M. Cinalli, and Craig B. Thompson. “Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival.” Mol Cell Biol 23, no. 20 (October 2003): 7315–28. https://doi.org/10.1128/MCB.23.20.7315-7328.2003.
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  - Rathmell, Jeffrey C., Rebecca L. Elstrom, Ryan M. Cinalli, and Craig B. Thompson. “Activated Akt promotes increased resting T cell size, CD28-independent T cell growth, and development of autoimmunity and lymphoma.” Eur J Immunol 33, no. 8 (August 2003): 2223–32. https://doi.org/10.1002/eji.200324048.
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  - Rathmell, Jeffrey C. “Apoptosis and B cell tolerance.” Curr Dir Autoimmun 6 (2003): 38–60. https://doi.org/10.1159/000066855.
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  - Rathmell, Jeffrey C., Tullia Lindsten, Wei-Xing Zong, Ryan M. Cinalli, and Craig B. Thompson. “Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis.” Nat Immunol 3, no. 10 (October 2002): 932–39. https://doi.org/10.1038/ni834.
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  - Plas, David R., Jeffrey C. Rathmell, and Craig B. Thompson. “Homeostatic control of lymphocyte survival: potential origins and implications.” Nat Immunol 3, no. 6 (June 2002): 515–21. https://doi.org/10.1038/ni0602-515.
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  - Frauwirth, Kenneth A., James L. Riley, Marian H. Harris, Richard V. Parry, Jeffrey C. Rathmell, David R. Plas, Rebecca L. Elstrom, Carl H. June, and Craig B. Thompson. “The CD28 signaling pathway regulates glucose metabolism.” Immunity 16, no. 6 (June 2002): 769–77. https://doi.org/10.1016/s1074-7613(02)00323-0.
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  - Rathmell, Jeffrey C., and Craig B. Thompson. “Pathways of apoptosis in lymphocyte development, homeostasis, and disease.” Cell 109 Suppl (April 2002): S97-107. https://doi.org/10.1016/s0092-8674(02)00704-3.
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  - Rathmell, J. C., E. A. Farkash, W. Gao, and C. B. Thompson. “IL-7 enhances the survival and maintains the size of naive T cells.” J Immunol 167, no. 12 (December 15, 2001): 6869–76. https://doi.org/10.4049/jimmunol.167.12.6869.
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  - Vander Heiden, M. G., D. R. Plas, J. C. Rathmell, C. J. Fox, M. H. Harris, and C. B. Thompson. “Growth factors can influence cell growth and survival through effects on glucose metabolism.” Mol Cell Biol 21, no. 17 (September 2001): 5899–5912. https://doi.org/10.1128/MCB.21.17.5899-5912.2001.
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  - Plas, D. R., S. Talapatra, A. L. Edinger, J. C. Rathmell, and C. B. Thompson. “Akt and Bcl-xL promote growth factor-independent survival through distinct effects on mitochondrial physiology.” J Biol Chem 276, no. 15 (April 13, 2001): 12041–48. https://doi.org/10.1074/jbc.M010551200.
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  - Lindsten, T., A. J. Ross, A. King, W. X. Zong, J. C. Rathmell, H. A. Shiels, E. Ulrich, et al. “The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues.” Mol Cell 6, no. 6 (December 2000): 1389–99. https://doi.org/10.1016/s1097-2765(00)00136-2.
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  - Rathmell, J. C., M. G. Vander Heiden, M. H. Harris, K. A. Frauwirth, and C. B. Thompson. “In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability.” Mol Cell 6, no. 3 (September 2000): 683–92. https://doi.org/10.1016/s1097-2765(00)00066-6.
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  - Goodnow, C. C., R. Glynne, D. Mack, B. Weintraub, J. Rathmell, J. I. Healy, S. Chaudhry, L. Miosge, A. Loy, and L. Wilson. “Mechanisms of self-tolerance and autoimmunity: from whole-animal phenotypes to molecular pathways.” Cold Spring Harb Symp Quant Biol 64 (1999): 313–22. https://doi.org/10.1101/sqb.1999.64.313.
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  - Rathmell, J. C., and C. B. Thompson. “The central effectors of cell death in the immune system.” Annu Rev Immunol 17 (1999): 781–828. https://doi.org/10.1146/annurev.immunol.17.1.781.
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  - Thompson, C. B., J. C. Rathmell, K. A. Frauwirth, T. Lindsten, C. M. Rudin, J. T. Opferman, P. G. Ashton-Rickardt, et al. “What keeps a resting T cell alive?” Cold Spring Harb Symp Quant Biol 64 (1999): 383–87. https://doi.org/10.1101/sqb.1999.64.383.
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  - Rathmell, J. C., and C. C. Goodnow. “The in vivo balance between B cell clonal expansion and elimination is regulated by CD95 both on B cells and in their micro-environment.” Immunol Cell Biol 76, no. 5 (October 1998): 387–94. https://doi.org/10.1046/j.1440-1711.1998.00774.x.
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  - Rathmell, J. C., S. Fournier, B. C. Weintraub, J. P. Allison, and C. C. Goodnow. “Repression of B7.2 on self-reactive B cells is essential to prevent proliferation and allow Fas-mediated deletion by CD4(+) T cells.” J Exp Med 188, no. 4 (August 17, 1998): 651–59. https://doi.org/10.1084/jem.188.4.651.
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  - Lin, H., J. C. Rathmell, G. S. Gray, C. B. Thompson, J. M. Leiden, and M. L. Alegre. “Cytotoxic T lymphocyte antigen 4 (CTLA4) blockade accelerates the acute rejection of cardiac allografts in CD28-deficient mice: CTLA4 can function independently of CD28.” J Exp Med 188, no. 1 (July 6, 1998): 199–204. https://doi.org/10.1084/jem.188.1.199.
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  - Fournier, S., J. C. Rathmell, C. C. Goodnow, and J. P. Allison. “T cell-mediated elimination of B7.2 transgenic B cells.” Immunity 6, no. 3 (March 1997): 327–39. https://doi.org/10.1016/s1074-7613(00)80335-0.
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  - Rathmell, J. C., S. E. Townsend, J. C. Xu, R. A. Flavell, and C. C. Goodnow. “Expansion or elimination of B cells in vivo: dual roles for CD40- and Fas (CD95)-ligands modulated by the B cell antigen receptor.” Cell 87, no. 2 (October 18, 1996): 319–29. https://doi.org/10.1016/s0092-8674(00)81349-5.
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  - Rathmell, J. C., and C. C. Goodnow. “Autoimmunity. The Fas track.” Curr Biol 5, no. 11 (November 1, 1995): 1218–21. https://doi.org/10.1016/s0960-9822(95)00241-7.
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  - Rathmell, J. C., M. P. Cooke, W. Y. Ho, J. Grein, S. E. Townsend, M. M. Davis, and C. C. Goodnow. “CD95 (Fas)-dependent elimination of self-reactive B cells upon interaction with CD4+ T cells.” Nature 376, no. 6536 (July 13, 1995): 181–84. https://doi.org/10.1038/376181a0.
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  - Goodnow, C. C., J. G. Cyster, S. B. Hartley, S. E. Bell, M. P. Cooke, J. I. Healy, S. Akkaraju, J. C. Rathmell, S. L. Pogue, and K. P. Shokat. “Self-tolerance checkpoints in B lymphocyte development.” Adv Immunol 59 (1995): 279–368. https://doi.org/10.1016/s0065-2776(08)60633-1.
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  - Rathmell, J. C., and C. C. Goodnow. “Effects of the lpr mutation on elimination and inactivation of self-reactive B cells.” J Immunol 153, no. 6 (September 15, 1994): 2831–42.
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- Book Sections
  - Andersen, J. L., and J. C. Rathmell. “Cell Death Pathways in Toxicological Response.” In Mammalian Toxicology, 75–83, 2015. https://doi.org/10.1002/9781118683484.ch4.
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  - Coloff, J. L., Y. Zhao, and J. C. Rathmell. “The integration of metabolism and cell death.” In Essentials of Apoptosis: A Guide for Basic and Clinical Research, 223–37, 2009. https://doi.org/10.1007/978-1-60327-381-7_9.
    Full Text

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