Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • M.D., Columbia University 1998
• 

  Previous Appointments & Affiliations

  • Associate Professor of Surgery, Surgery, Cardiovascular and Thoracic Surgery, Surgery 2017 - 2020
  • Associate Professor of Surgery, Surgery, Cardiovascular and Thoracic Surgery, Surgery 2016 - 2017
  • Assistant Professor of Surgery, Surgery, Cardiovascular and Thoracic Surgery, Surgery 2008 - 2015
• Research
• 

  Selected Grants

  • A Prospective, global study designed to collect real-world clinical outcomes of the MITRIS RESILIA mitral valve - North America (MOMENTIS Study) awarded by Edwards Lifesciences Corporation 2023 - 2038
  • Percutaneous or Surgical Mitral Valve Repair in Patients with Primary Mitral Regurgitation whose mitral valve has been determined to be suitable for correction by MV repair surgery awarded by Evalve Inc. 2021 - 2033
  • Portico Re-sheathable Transcatheter Aortic Valve System US IDE Trial (PORTICO) awarded by St. Jude Medical Inc. 2014 - 2023
  • Core Clinical Centers for the CTSN awarded by National Institutes of Health 2007 - 2018
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Bishawi, Muath, Carmelo Milano, Jeffrey Gaca, Andrew Wang, Keith Carr, and Donald D. Glower. “Late Durability of Mitral Repair for Ischemic Versus Nonischemic Functional Mitral Regurgitation.” Ann Thorac Surg 114, no. 4 (October 2022): 1358–65. https://doi.org/10.1016/j.athoracsur.2021.08.021.
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    • McGauvran, Michelle Maureen, Tetsu Ohnuma, Karthik Raghunathan, Vijay Krishnamoorthy, Selby Johnson, Theresa Lo, Srinivas Pyati, et al. “Association Between Gabapentinoids and Postoperative Pulmonary Complications in Patients Undergoing Thoracic Surgery.” J Cardiothorac Vasc Anesth 36, no. 8 Pt A (August 2022): 2295–2302. https://doi.org/10.1053/j.jvca.2021.10.003.
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    • Vekstein, Andrew M., Julie W. Doberne, E Hope Weissler, Charles M. Wojnarski, Chandler A. Long, Adam R. Williams, Ryan P. Plichta, Jeffrey G. Gaca, and G Chad Hughes. “Tailored approach and outcomes of aortic arch reconstruction after acute type A dissection repair.” J Thorac Cardiovasc Surg, February 16, 2022. https://doi.org/10.1016/j.jtcvs.2022.02.016.
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    • Bishawi, Muath, Carmelo Milano, Jeffrey Gaca, Keith Carr, Andrew Wang, and Donald D. Glower. “The outcome of mitral repair for degenerative versus ischemic mitral regurgitation using a single complete ring.” J Card Surg 37, no. 2 (February 2022): 290–96. https://doi.org/10.1111/jocs.16094.
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    • Nellis, Joseph R., Mani A. Daneshmand, Jeffrey G. Gaca, Nicholas D. Andersen, John C. Haney, and Joseph W. Turek. “A single center experience with minimally invasive approaches in congenital cardiac surgery.” J Thorac Dis 13, no. 10 (October 2021): 5818–25. https://doi.org/10.21037/jtd-21-836.
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    • Glower, Donald D., and Jeffrey Gaca. “Surgical risk scores: A roadmap to improved outcome?” J Card Surg 36, no. 7 (July 2021): 2452–53. https://doi.org/10.1111/jocs.15569.
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    • Wojnarski, Charles M., Parth A. Chodavadia, Yaron D. Barac, Jenna L. Armstrong, Andrew M. Vekstein, John C. Haney, Jeffrey G. Gaca, G. Chad Hughes, and Donald D. Glower. “Long-term outcomes of aortic root replacement for endocarditis.” J Card Surg 36, no. 6 (June 2021): 1969–78. https://doi.org/10.1111/jocs.15472.
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    • Barac, Yaron D., Rahul S. Loungani, Richard Sabulsky, Brittany Zwischenberger, Jeffrey Gaca, Keith Carr, and Donald D. Glower. “Robotic versus port-access mitral repair: A propensity score analysis.” J Card Surg 36, no. 4 (April 2021): 1219–25. https://doi.org/10.1111/jocs.15342.
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    • Weissler, E Hope, Soraya L. Voigt, Vignesh Raman, Oliver Jawitz, Julie Doberne, Jatin Anand, Ryan Plichta, Jeffrey G. Gaca, Richard L. McCann, and G Chad Hughes. “Permissive Hypertension and Collateral Revascularization May Allow Avoidance of Cerebrospinal Fluid Drainage in Thoracic Endovascular Aortic Repair.” Ann Thorac Surg 110, no. 5 (November 2020): 1469–74. https://doi.org/10.1016/j.athoracsur.2020.04.101.
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    • Schwartz, Fides Regina, Tina Tailor, Jeffrey G. Gaca, Todd Kiefer, Kevin Harrison, G Chad Hughes, Juan-Carlos Ramirez-Giraldo, Daniele Marin, and Lynne M. Hurwitz. “Impact of dual energy cardiac CT for metal artefact reduction post aortic valve replacement.” Eur J Radiol 129 (August 2020): 109135. https://doi.org/10.1016/j.ejrad.2020.109135.
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    • Pineda, Andrés M., Jennifer Rymer, Alice Wang, Adam Z. Banks, Lynne H. Koweek, Ryan Plichta, Adam Williams, et al. “Transcatheter aortic valve replacement for patients with severe bicuspid aortic stenosis.” Am Heart J 224 (June 2020): 105–12. https://doi.org/10.1016/j.ahj.2020.02.003.
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    • Faure, Marguerite E., Dominika Suchá, Fides R. Schwartz, Petr Symersky, Ad J. J. C. Bogers, Jeffrey G. Gaca, Lynne M. Koweek, Linda M. de Heer, and Ricardo P. J. Budde. “Surgically implanted aortic valve bioprostheses deform after implantation: insights from computed tomography.” Eur Radiol 30, no. 5 (May 2020): 2651–57. https://doi.org/10.1007/s00330-019-06634-6.
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    • Friedman, Daniel J., Jeffrey G. Gaca, Tongrong Wang, S Chris Malaisrie, David R. Holmes, Jonathan P. Piccini, Rakesh M. Suri, et al. “Use of left atrial appendage occlusion among older cardiac surgery patients with preoperative atrial fibrillation: a national cohort study.” J Interv Card Electrophysiol 57, no. 3 (April 2020): 399–407. https://doi.org/10.1007/s10840-019-00519-w.
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    • Jawitz, Oliver K., Brian C. Gulack, J Matthew Brennan, Dylan P. Thibault, Alice Wang, Sean M. O’Brien, Jacob N. Schroder, Jeffrey G. Gaca, and Peter K. Smith. “Association of postoperative complications and outcomes following coronary artery bypass grafting.” Am Heart J 222 (April 2020): 220–28. https://doi.org/10.1016/j.ahj.2020.02.002.
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    • Banks, Adam, Jeff Gaca, and Todd Kiefer. “Review of alternative access in transcatheter aortic valve replacement.” Cardiovasc Diagn Ther 10, no. 1 (February 2020): 72–82. https://doi.org/10.21037/cdt.2019.10.01.
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    • Gaca, Jeffrey G. “Acting In Good Faith: Operating Without Truly Informed Consent.” Ann Thorac Surg 108, no. 6 (December 2019): 1613–14. https://doi.org/10.1016/j.athoracsur.2019.08.013.
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    • Williams, Judson B., and Jeffrey G. Gaca. “Commentary: Thank you, sir, may I TAVI another: Procedural problems and postoperative complications in SURTAVI.” J Thorac Cardiovasc Surg 158, no. 3 (September 2019): 729–30. https://doi.org/10.1016/j.jtcvs.2018.11.079.
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    • Pineda, Andrés M., Jennifer Rymer, Alice Wang, Lynne H. Koweek, Adam Williams, Todd Kiefer, Andrew Wang, Jeffrey Gaca, G Chad Hughes, and J Kevin Harrison. “Trends and Outcomes of Alternative-Access Transcatheter Aortic Valve Replacement.” J Invasive Cardiol 31, no. 7 (July 2019): E184–91.
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    • Klinger, Rebecca Y., Mary Cooter, Tiffany Bisanar, Niccolò Terrando, Miles Berger, Mihai V. Podgoreanu, Mark Stafford-Smith, Mark F. Newman, Joseph P. Mathew, and Joseph P. Neurologic Outcomes Research Group of the Duke Heart Center. “Intravenous Lidocaine Does Not Improve Neurologic Outcomes after Cardiac Surgery: A Randomized Controlled Trial.” Anesthesiology 130, no. 6 (June 2019): 958–70. https://doi.org/10.1097/ALN.0000000000002668.
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    • Gamble, John F., Cory D. Maxwell, Jeffrey Gaca, Nicole R. Guinn, Brian C. Cho, Steven M. Frank, and Pierre R. Tibi. “Successful Ascending Aorta and Hemiarch Replacement and Aortic Valve Resuspension Via Redo Median Sternotomy Using Hypothermic Circulatory Arrest in a Practicing Jehovah's Witnesses Patient.” J Cardiothorac Vasc Anesth 33, no. 5 (May 2019): 1447–54. https://doi.org/10.1053/j.jvca.2018.12.019.
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    • Hashmi, Nazish K., Kamrouz Ghadimi, Amudan J. Srinivasan, Yi-Ju Li, Robert D. Raiff, Jeffrey G. Gaca, Adam G. Root, et al. “Three-factor prothrombin complex concentrates for refractory bleeding after cardiovascular surgery within an algorithmic approach to haemostasis.” Vox Sang 114, no. 4 (May 2019): 374–85. https://doi.org/10.1111/vox.12774.
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    • Waldron, Nathan H., Mary Cooter, John C. Haney, Jacob N. Schroder, Jeffrey G. Gaca, Shu S. Lin, Martin I. Sigurdsson, et al. “Temporary autonomic modulation with botulinum toxin type A to reduce atrial fibrillation after cardiac surgery.” Heart Rhythm 16, no. 2 (February 2019): 178–84. https://doi.org/10.1016/j.hrthm.2018.08.021.
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    • Smith, Patrick J., Jeffrey N. Browndyke, Zachary A. Monge, Todd B. Harshbarger, Michael L. James, Jeffrey G. Gaca, John H. Alexander, et al. “Longitudinal Changes in Regional Cerebral Perfusion and Cognition After Cardiac Operation.” Ann Thorac Surg 107, no. 1 (January 2019): 112–18. https://doi.org/10.1016/j.athoracsur.2018.07.056.
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    • Williams, Judson B., and Jeffrey G. Gaca. “The Mind Is Your Best Muscle: TAVR/SAVR Outcomes in Patients With Cognitive Impairment.” Semin Thorac Cardiovasc Surg 31, no. 3 (2019): 381–82. https://doi.org/10.1053/j.semtcvs.2019.02.010.
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    • Inohara, Taku, Pratik Manandhar, Andrzej S. Kosinski, Roland A. Matsouaka, Shun Kohsaka, Robert J. Mentz, Vinod H. Thourani, et al. “Association of Renin-Angiotensin Inhibitor Treatment With Mortality and Heart Failure Readmission in Patients With Transcatheter Aortic Valve Replacement.” Jama 320, no. 21 (December 4, 2018): 2231–41. https://doi.org/10.1001/jama.2018.18077.
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    • Zwischenberger, Brittany A., Yaron D. Barac, Andrew Wang, Jeffrey G. Gaca, and Donald D. Glower. “Is Septal Myectomy Needed During Mitral Replacement for Hypertrophic Obstructive Cardiomyopathy?” Ann Thorac Surg 106, no. 6 (December 2018): 1892. https://doi.org/10.1016/j.athoracsur.2018.06.074.
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    • Wang, Andrew, Jeffrey G. Gaca, and Vivian H. Chu. “Injection Drug Use-Associated Infective Endocarditis-Reply.” Jama 320, no. 18 (November 13, 2018): 1939–40. https://doi.org/10.1001/jama.2018.14075.
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    • McCartney, Sharon L., and Jeffrey G. Gaca. “Invited Commentary: A Case of Multiple Ventricular Gradients.” J Cardiothorac Vasc Anesth 32, no. 4 (August 2018): 1833–34. https://doi.org/10.1053/j.jvca.2018.01.039.
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    • Wang, Andrew, Jeffrey G. Gaca, and Vivian H. Chu. “Management Considerations in Infective Endocarditis: A Review.” Jama 320, no. 1 (July 3, 2018): 72–83. https://doi.org/10.1001/jama.2018.7596.
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    • Barac, Yaron D., Brittany Zwischenberger, Jacob N. Schroder, Mani A. Daneshmand, John C. Haney, Jeffrey G. Gaca, Andrew Wang, Carmelo A. Milano, and Donald D. Glower. “Using a Regent Aortic Valve in a Small Annulus Mitral Position Is a Viable Option.” Ann Thorac Surg 105, no. 4 (April 2018): 1200–1204. https://doi.org/10.1016/j.athoracsur.2017.11.042.
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    • Friedman, Daniel J., Jonathan P. Piccini, Tongrong Wang, Jiayin Zheng, S Chris Malaisrie, David R. Holmes, Rakesh M. Suri, et al. “Association Between Left Atrial Appendage Occlusion and Readmission for Thromboembolism Among Patients With Atrial Fibrillation Undergoing Concomitant Cardiac Surgery.” Jama 319, no. 4 (January 23, 2018): 365–74. https://doi.org/10.1001/jama.2017.20125.
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    • Karhausen, Jörn A., Alan M. Smeltz, Igor Akushevich, Mary Cooter, Mihai V. Podgoreanu, Mark Stafford-Smith, Susan M. Martinelli, Manuel L. Fontes, and Miklos D. Kertai. “Platelet Counts and Postoperative Stroke After Coronary Artery Bypass Grafting Surgery.” Anesth Analg 125, no. 4 (October 2017): 1129–39. https://doi.org/10.1213/ANE.0000000000002187.
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    • Teeter, Emily G., Claire Dakik, Mary Cooter, Zainab Samad, Kamrouz Ghadimi, J Kevin Harrison, Jeffery Gaca, Mark Stafford-Smith, and Brandi A. Bottiger. “Assessment of Paravalvular Leak After Transcatheter Aortic Valve Replacement: Transesophageal Echocardiography Compared With Transthoracic Echocardiography.” J Cardiothorac Vasc Anesth 31, no. 4 (August 2017): 1278–84. https://doi.org/10.1053/j.jvca.2017.03.010.
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    • Patel, Prakash A., Abraham M. Ackermann, John G. T. Augoustides, Joerg Ender, Jacob T. Gutsche, Jay Giri, Prashanth Vallabhajosyula, et al. “Anesthetic Evolution in Transcatheter Aortic Valve Replacement: Expert Perspectives From High-Volume Academic Centers in Europe and the United States.” J Cardiothorac Vasc Anesth 31, no. 3 (June 2017): 777–90. https://doi.org/10.1053/j.jvca.2017.02.051.
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    • Iribarne, Alexander, Jeffrey Keenan, Ehsan Benrashid, Hanghang Wang, James M. Meza, Asvin Ganapathi, Jeffrey G. Gaca, Han W. Kim, Lynne M. Hurwitz, and G Chad Hughes. “Imaging Surveillance After Proximal Aortic Operations: Is it Necessary?” Ann Thorac Surg 103, no. 3 (March 2017): 734–41. https://doi.org/10.1016/j.athoracsur.2016.06.085.
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    • Wang, Alice, Sharon L. McCartney, Judson B. Williams, Asvin Ganapathi, Donald D. Glower, Alina Nicoara, and Jeffrey G. Gaca. “Use of Adjuncts Reduces Cardiopulmonary Bypass Time During Minimally Invasive Aortic Valve Replacement.” J Heart Valve Dis 26, no. 2 (March 2017): 155–60.
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    • Browndyke, Jeffrey N., Miles Berger, Todd B. Harshbarger, Patrick J. Smith, William White, Tiffany L. Bisanar, John H. Alexander, et al. “Resting-State Functional Connectivity and Cognition After Major Cardiac Surgery in Older Adults without Preoperative Cognitive Impairment: Preliminary Findings.” J Am Geriatr Soc 65, no. 1 (January 2017): e6–12. https://doi.org/10.1111/jgs.14534.
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    • Kertai, Miklos D., Shan Zhou, Jörn A. Karhausen, Mary Cooter, Edmund Jooste, Yi-Ju Li, William D. White, et al. “In Reply.” Anesthesiology 125, no. 2 (August 2016): 438–39. https://doi.org/10.1097/ALN.0000000000001190.
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    • Shah, Asad A., Donald D. Glower, and Jeffrey G. Gaca. “Trans-aortic Alfieri stitch at the time of septal myectomy for hypertrophic obstructive cardiomyopathy.” J Card Surg 31, no. 8 (August 2016): 503–6. https://doi.org/10.1111/jocs.12804.
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    • Yerokun, Babatunde A., Judson B. Williams, Jeffrey Gaca, Peter K. Smith, and Matthew T. Roe. “Indications, algorithms, and outcomes for coronary artery bypass surgery in patients with acute coronary syndromes.” Coron Artery Dis 27, no. 4 (June 2016): 319–26. https://doi.org/10.1097/MCA.0000000000000364.
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    • Andersen, Nicholas D., Ehsan Benrashid, Adia K. Ross, Lisa C. Pickett, Peter K. Smith, Mani A. Daneshmand, Jacob N. Schroder, Jeffrey G. Gaca, and G Chad Hughes. “The utility of the aortic dissection team: outcomes and insights after a decade of experience.” Ann Cardiothorac Surg 5, no. 3 (May 2016): 194–201. https://doi.org/10.21037/acs.2016.05.12.
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    • Ranney, David N., Judson B. Williams, Andrew Wang, and Jeffrey G. Gaca. “Valve-in-Valve Transcatheter Valve Implantation in the Nonaortic Position.” J Card Surg 31, no. 5 (May 2016): 282–88. https://doi.org/10.1111/jocs.12745.
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    • Hanna, Jennifer M., Jeffrey E. Keenan, Hanghang Wang, Nicholas D. Andersen, Jeffrey G. Gaca, Frederick W. Lombard, Ian J. Welsby, and G Chad Hughes. “Use of human fibrinogen concentrate during proximal aortic reconstruction with deep hypothermic circulatory arrest.” J Thorac Cardiovasc Surg 151, no. 2 (February 2016): 376–82. https://doi.org/10.1016/j.jtcvs.2015.08.079.
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    • Kertai, Miklos D., Shan Zhou, Jörn A. Karhausen, Mary Cooter, Edmund Jooste, Yi-Ju Li, William D. White, et al. “Platelet Counts, Acute Kidney Injury, and Mortality after Coronary Artery Bypass Grafting Surgery.” Anesthesiology 124, no. 2 (February 2016): 339–52. https://doi.org/10.1097/ALN.0000000000000959.
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    • Williams, Judson, Matthew M. Sherwood, Andrew Wang, and Jeffrey G. Gaca. “Balloon-Expandable Device for Non-Aortic Valve in Valve Transcatheter Heart Valve Implantation.” Cardiology 134, no. 2 (January 1, 2016): 239–239.
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    • Stafford-Smith, Mark, Yi-Ju Li, Joseph P. Mathew, Yen-Wei Li, Yunqi Ji, Barbara G. Phillips-Bute, Carmelo A. Milano, et al. “Genome-wide association study of acute kidney injury after coronary bypass graft surgery identifies susceptibility loci.” Kidney Int 88, no. 4 (October 2015): 823–32. https://doi.org/10.1038/ki.2015.161.
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    • Tang, Paul, Mark Onaitis, Jeffrey G. Gaca, Carmelo A. Milano, Mark Stafford-Smith, and Donald Glower. “Right Minithoracotomy Versus Median Sternotomy for Mitral Valve Surgery: A Propensity Matched Study.” Ann Thorac Surg 100, no. 2 (August 2015): 575–81. https://doi.org/10.1016/j.athoracsur.2015.04.027.
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    • Cherry, Anne D., Alina Nicoara, Scott H. McQuilkin, Jeffrey G. Gaca, and J Mauricio Del Rio. “Multimodal Evaluation of Aortic Regurgitation After Mitral and Tricuspid Valve Repairs.” Anesth Analg 121, no. 2 (August 2015): 319–22. https://doi.org/10.1213/ANE.0000000000000739.
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    • Esper, Stephen A., Brandi A. Bottiger, Brian Ginsberg, J Mauricio Del Rio, Donald D. Glower, Jeffrey G. Gaca, Mark Stafford-Smith, Peter J. Neuburger, and Mark A. Chaney. “CASE 8--2015. Paravertebral Catheter-Based Strategy for Primary Analgesia After Minimally Invasive Cardiac Surgery.” J Cardiothorac Vasc Anesth 29, no. 4 (August 2015): 1071–80. https://doi.org/10.1053/j.jvca.2015.02.018.
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    • Ganapathi, Asvin M., Sameer A. Hirji, Andrew Wang, Chetan B. Patel, Jeffrey G. Gaca, and Jacob N. Schroder. “Bridge to long-term mechanical circulatory support with a left ventricular assist device: novel use of transcatheter aortic valve replacement.” Ann Thorac Surg 99, no. 4 (April 2015): e91–93. https://doi.org/10.1016/j.athoracsur.2014.12.087.
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    • Walker, Wendy L., Daniel T. Boll, Juliana M. Bueno, Todd L. Kiefer, John P. Vavalle, Jeffrey G. Gaca, J Kevin Harrison, G Chad Hughes, Andrew Wang, and Lynne M. Hurwitz. “Assessment of single-bolus contrast administration technique using hybrid dual-source ECG-gated thoracic and dual-source non-ECG-gated high-pitch abdominopelvic CT acquisitions for procedural planning before transcatheter aortic valve replacement.” J Comput Assist Tomogr 39, no. 2 (2015): 207–12. https://doi.org/10.1097/RCT.0000000000000194.
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    • Ganapathi, Asvin M., Jennifer M. Hanna, Matthew A. Schechter, Brian R. Englum, Anthony W. Castleberry, Jeffrey G. Gaca, and G Chad Hughes. “Antegrade versus retrograde cerebral perfusion for hemiarch replacement with deep hypothermic circulatory arrest: does it matter? A propensity-matched analysis.” J Thorac Cardiovasc Surg 148, no. 6 (December 2014): 2896–2902. https://doi.org/10.1016/j.jtcvs.2014.04.014.
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    • DeLong, Michael R., Duncan B. Hughes, Jeffrey G. Gaca, John P. Fischer, Jennifer E. Bond, W Clark Hargrove, Pavan Atluri, L Scott Levin, and Detlev Erdmann. “Sternal talon offers a solution for secondary sternum osteosynthesis in patients with nonunion.” Ann Thorac Surg 98, no. 5 (November 2014): 1804–8. https://doi.org/10.1016/j.athoracsur.2014.06.048.
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    • Andersen, Nicholas D., Asvin M. Ganapathi, Jennifer M. Hanna, Judson B. Williams, Jeffrey G. Gaca, and G Chad Hughes. “Outcomes of acute type a dissection repair before and after implementation of a multidisciplinary thoracic aortic surgery program.” J Am Coll Cardiol 63, no. 17 (May 6, 2014): 1796–1803. https://doi.org/10.1016/j.jacc.2013.10.085.
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    • Andersen, Nicholas D., Jeffrey E. Keenan, Asvin M. Ganapathi, Jeffrey G. Gaca, Richard L. McCann, and G Chad Hughes. “Current management and outcome of chronic type B aortic dissection: results with open and endovascular repair since the advent of thoracic endografting.” Ann Cardiothorac Surg 3, no. 3 (May 2014): 264–74. https://doi.org/10.3978/j.issn.2225-319X.2014.05.07.
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    • Gaca, Jeffrey G., Robert M. Clare, J Scott Rankin, Mani A. Daneshmand, Carmelo A. Milano, G Chad Hughes, Walter G. Wolfe, Donald D. Glower, and Peter K. Smith. “Risk-adjusted survival after tissue versus mechanical aortic valve replacement: a 23-year assessment.” J Heart Valve Dis 22, no. 6 (November 2013): 810–16.
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    • Kiefer, Todd L., John Vavalle, Sharif Halim, Prashant Kaul, J Larry Klein, Lynne H. Hurwitz, Jeffrey G. Gaca, and J Kevin Harrison. “Anterograde percutaneous coronary-cameral fistula closure employing a guide-in-guide technique.” Jacc Cardiovasc Interv 6, no. 10 (October 2013): 1105–7. https://doi.org/10.1016/j.jcin.2013.03.023.
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    • Parsa, Cyrus J., Linda K. Shaw, J Scott Rankin, Mani A. Daneshmand, Jeffrey G. Gaca, Carmelo A. Milano, Donald D. Glower, and Peter K. Smith. “Twenty-five-year outcomes after multiple internal thoracic artery bypass.” J Thorac Cardiovasc Surg 145, no. 4 (April 2013): 970–75. https://doi.org/10.1016/j.jtcvs.2012.11.093.
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    • Aronson, Solomon, Barbara Phillips-Bute, Mark Stafford-Smith, Manuel Fontes, Jeffrey Gaca, Joseph P. Mathew, and Mark F. Newman. “The association of postcardiac surgery acute kidney injury with intraoperative systolic blood pressure hypotension.” Anesthesiol Res Pract 2013 (2013): 174091. https://doi.org/10.1155/2013/174091.
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    • Hughes, G Chad, Yue Zhao, J Scott Rankin, John E. Scarborough, Sean O’Brien, Joseph E. Bavaria, Walter G. Wolfe, et al. “Effects of institutional volumes on operative outcomes for aortic root replacement in North America.” J Thorac Cardiovasc Surg 145, no. 1 (January 2013): 166–70. https://doi.org/10.1016/j.jtcvs.2011.10.094.
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    • Rankin, J. S., M. A. Daneshmand, C. A. Milano, J. G. Gaca, D. D. Glower, and P. K. Smith. “Mitral valve repair for ischemic mitral regurgitation: review of current techniques.” Heart Lung Vessel 5, no. 4 (2013): 246–51.
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    • Tang, Paul, Mark Onaitis, Bhargavi Desai, Jeffrey G. Gaca, Carmelo A. Milano, Mark Stafford-Smith, and Donald D. Glower. “Minithoracotomy versus sternotomy for mitral surgery in patients with chronic renal impairment: a propensity-matched study.” Innovations (Phila) 8, no. 5 (2013): 325–31. https://doi.org/10.1097/IMI.0000000000000020.
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    • Andersen, Nicholas D., Syamal D. Bhattacharya, Judson B. Williams, Emil L. Fosbol, Evelyn L. Lockhart, Mayur B. Patel, Jeffrey G. Gaca, Ian J. Welsby, and G Chad Hughes. “Intraoperative use of low-dose recombinant activated factor VII during thoracic aortic operations.” Ann Thorac Surg 93, no. 6 (June 2012): 1921–28. https://doi.org/10.1016/j.athoracsur.2012.02.037.
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    • Bennett-Guerrero, Elliott, Barbara Phillips-Bute, Peter M. Waweru, Jeffrey G. Gaca, James C. Spann, and Carmelo A. Milano. “Pilot study of sternal plating for primary closure of the sternum in cardiac surgical patients.” Innovations (Phila) 6, no. 6 (November 2011): 382–88. https://doi.org/10.1097/IMI.0b013e318248fbda.
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    • Rankin, J Scott, and Jeffrey G. Gaca. “Techniques of aortic valve repair.” Innovations (Phila) 6, no. 6 (November 2011): 348–54. https://doi.org/10.1097/IMI.0b013e31824641d7.
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    • Lima, Brian, Judson B. Williams, S Dave Bhattacharya, Asad A. Shah, Nicholas Andersen, Jeffrey G. Gaca, and G Chad Hughes. “Results of proximal arch replacement using deep hypothermia for circulatory arrest: is moderate hypothermia really justifiable?” Am Surg 77, no. 11 (November 2011): 1438–44.
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    • Rankin, J Scott, Jeffrey G. Gaca, Louis A. Brunsting, Mani A. Daneshmand, Carmelo A. Milano, Donald D. Glower, and Peter K. Smith. “Increasing mitral valve repair rates with nonresectional techniques.” Innovations (Phila) 6, no. 4 (July 2011): 209–20. https://doi.org/10.1097/IMI.0b013e3182181b4b.
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    • Swaminathan, Madhav, Alina Nicoara, Barbara G. Phillips-Bute, Nicolas Aeschlimann, Carmelo A. Milano, G Burkhard Mackensen, Mihai V. Podgoreanu, et al. “Utility of a simple algorithm to grade diastolic dysfunction and predict outcome after coronary artery bypass graft surgery.” Ann Thorac Surg 91, no. 6 (June 2011): 1844–50. https://doi.org/10.1016/j.athoracsur.2011.02.008.
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    • Gaca, Jeffrey G., Shubin Sheng, Mani A. Daneshmand, Sean O’Brien, J Scott Rankin, J Matthew Brennan, G Chad Hughes, Donald D. Glower, James S. Gammie, and Peter K. Smith. “Outcomes for endocarditis surgery in North America: a simplified risk scoring system.” J Thorac Cardiovasc Surg 141, no. 1 (January 2011): 98-106.e1-2. https://doi.org/10.1016/j.jtcvs.2010.09.016.
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    • Parsa, C. J., M. A. Daneshmand, J. G. Gaca, and J. S. Rankin. “Arterial bypass grafting of the coronary circulation.” Hsr Proc Intensive Care Cardiovasc Anesth 3, no. 4 (2011): 227–34.
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    • Aronson, Solomon, Mark Stafford-Smith, Barbara Phillips-Bute, Andrew Shaw, Jeffrey Gaca, Mark Newman, and Mark Cardiothoracic Anesthesiology Research Endeavors. “Intraoperative systolic blood pressure variability predicts 30-day mortality in aortocoronary bypass surgery patients.” Anesthesiology 113, no. 2 (August 2010): 305–12. https://doi.org/10.1097/ALN.0b013e3181e07ee9.
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    • Nikolov, Nikolay M., Manuel L. Fontes, William D. White, Solomon Aronson, Shahar Bar-Yosef, Jeffrey G. Gaca, Mihai V. Podgoreanu, Mark Stafford-Smith, Mark F. Newman, and Joseph P. Mathew. “Pulse pressure and long-term survival after coronary artery bypass graft surgery.” Anesth Analg 110, no. 2 (February 1, 2010): 335–40. https://doi.org/10.1213/ANE.0b013e3181c76f87.
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    • Rajagopal, Keshava, Joseph G. Rogers, Andrew J. Lodge, Jeffrey G. Gaca, Richard L. McCann, Carmelo A. Milano, and G Chad Hughes. “Two-stage total cardioaortic replacement for end-stage heart and aortic disease in Marfan syndrome: case report and review of the literature.” J Heart Lung Transplant 28, no. 9 (September 2009): 958–63. https://doi.org/10.1016/j.healun.2009.05.012.
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    • Gaca, Jeffrey G., Brian Lima, Carmelo A. Milano, Shu S. Lin, R Duane Davis, James E. Lowe, and Peter K. Smith. “Laser-assisted extraction of pacemaker and defibrillator leads: the role of the cardiac surgeon.” Ann Thorac Surg 87, no. 5 (May 2009): 1446–50. https://doi.org/10.1016/j.athoracsur.2009.02.015.
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    • Cantu, E., K. R. Balsara, B. Li, C. Lau, S. Gibson, A. Wyse, K. Baig, et al. “Prolonged function of macrophage, von Willebrand factor-deficient porcine pulmonary xenografts.” Am J Transplant 7, no. 1 (January 2007): 66–75. https://doi.org/10.1111/j.1600-6143.2006.01603.x.
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    • Gaca, Jeffrey G., James Z. Appel, Jeffrey G. Lukes, Gonzalo V. Gonzalez-Stawinski, Aaron Lesher, Daniel Palestrant, John S. Logan, et al. “Effect of an anti-C5a monoclonal antibody indicates a prominent role for anaphylatoxin in pulmonary xenograft dysfunction.” Transplantation 81, no. 12 (June 27, 2006): 1686–94. https://doi.org/10.1097/01.tp.0000226063.36325.02.
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    • Cantu, Edward, Jeffrey G. Gaca, Daniel Palestrant, Kamran Baig, Daniel J. Lukes, Sarah E. Gibson, Gonzalo V. Gonzalez-Stawinski, Michael Olausson, William Parker, and R Duane Davis. “Depletion of pulmonary intravascular macrophages prevents hyperacute pulmonary xenograft dysfunction.” Transplantation 81, no. 8 (April 27, 2006): 1157–64. https://doi.org/10.1097/01.tp.0000169758.57679.2a.
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    • Gaca, Jeffrey G., Rebecca P. Petersen, Bercedis L. Peterson, David H. Harpole, Thomas A. D’Amico, Theodore N. Pappas, Hilliard F. Seigler, Walter G. Wolfe, and Douglas S. Tyler. “Pathologic nodal status predicts disease-free survival after neoadjuvant chemoradiation for gastroesophageal junction carcinoma.” Ann Surg Oncol 13, no. 3 (March 2006): 340–46. https://doi.org/10.1245/ASO.2006.02.023.
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    • Lukes, D. J., E. Cantu, J. G. Gaca, E. Hallberg, A. Karlsson-Parra, W. Parker, M. Olausson, and R. D. Davis. “Oral feeding with pig peripheral lymphocytes decreases the xenogeneic delayed type hypersensitivity reaction in galactosyltransferase knockout mice.” Transplant Proc 37, no. 8 (October 2005): 3327–31. https://doi.org/10.1016/j.transproceed.2005.09.005.
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    • Fields, Ryan C., Kamran Baig, Jeffrey Gaca, Luther G. Milton, Walter J. Koch, and Jeffrey H. Lawson. “Reduction of vascular intimal-medial hyperplasia in polytetrafluoroethylene arteriovenous grafts via expression of an inhibitor of G protein signaling.” Ann Vasc Surg 19, no. 5 (September 2005): 712–18. https://doi.org/10.1007/s10016-005-6805-9.
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    • Gaca, Jeffrey G., Daniel Palestrant, Daniel J. Lukes, Michael Olausson, William Parker, and R Duane Davis. “Prevention of acute lung injury in swine: depletion of pulmonary intravascular macrophages using liposomal clodronate.” J Surg Res 112, no. 1 (June 1, 2003): 19–25. https://doi.org/10.1016/s0022-4804(03)00142-2.
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    • Baig, K., R. C. Fields, J. Gaca, S. Hanish, L. G. Milton, W. J. Koch, and J. H. Lawson. “A porcine model of intimal-medial hyperplasia in polytetrafluoroethylene arteriovenous grafts.” J Vasc Access 4, no. 3 (2003): 111–17.
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    • Gaca, Jeffrey G., Aaron Lesher, Olcay Aksoy, Zaverio M. Ruggeri, William Parker, and R Duane Davis. “The role of the porcine von Willebrand factor: baboon platelet interactions in pulmonary xenotransplantation.” Transplantation 74, no. 11 (December 15, 2002): 1596–1603. https://doi.org/10.1097/00007890-200212150-00018.
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    • Lau, C. L., S. M. Palmer, D. N. Howell, R. McMahon, D. Hadjiliadis, J. Gaca, T. N. Pappas, R. D. Davis, and S. Eubanks. “Laparoscopic antireflux surgery in the lung transplant population.” Surg Endosc 16, no. 12 (December 2002): 1674–78. https://doi.org/10.1007/s00464-001-8251-2.
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    • Gaca, Jeffrey G., Aaron Lesher, Olcay Aksoy, Gonzalo V. Gonzalez-Stawinski, Jeffrey L. Platt, Jeffrey H. Lawson, William Parker, and R Duane Davis. “Disseminated intravascular coagulation in association with pig-to-primate pulmonary xenotransplantation.” Transplantation 73, no. 11 (June 15, 2002): 1717–23. https://doi.org/10.1097/00007890-200206150-00005.
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    • Gonzalez-Stawinski, Gonzalo V., Casey W. Daggett, Christine L. Lau, Sujatha Karoor, Stephanie D. Love, John S. Logan, Jeffrey G. Gaca, William Parker, and Robert Duane Davis. “Non-anti-Gal alpha1-3Gal antibody mechanisms are sufficient to cause hyperacute lung dysfunction in pulmonary xenotransplantation.” J Am Coll Surg 194, no. 6 (June 2002): 765–73. https://doi.org/10.1016/s1072-7515(02)01162-6.
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    • Lee, Winston, Jeffrey G. Gaca, Lindsay A. Edwards, Steven J. Braedehoeft, William Parker, and R Duane Davis. “Binding of polyreactive antibodies to self versus foreign antigens.” Immunobiology 205, no. 1 (March 2002): 95–107. https://doi.org/10.1078/0171-2985-00113.
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    • Gaca, J. G., W. Lee, O. Aksoy, S. J. Braedehoeft, G. V. Gonzalez-Stawinski, W. Parker, and R. D. Davis. “Evidence for polyreactive xenoreactive antibodies in the repertoire of human anti-swine antibodies: the 'next' humoral barrier to xenotransplantation?” Transpl Immunol 9, no. 1 (October 2001): 19–27. https://doi.org/10.1016/s0966-3274(01)00047-8.
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  • Book Sections

    • Benkert, A. R., and J. G. Gaca. “Initial Medical Management of Acute Aortic Syndromes.” In Aortic Dissection and Acute Aortic Syndromes, 119–30, 2021. https://doi.org/10.1007/978-3-030-66668-2_9.
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    • Del Rio, J. M., J. G. Gaca, M. A. Daneshmand, and M. Swaminathan. “Thoracoabdominal aortic aneurysms.” In Yao & Artusio’s Anesthesiology: Problem-Oriented Patient Management: Seventh Edition, 241–76, 2012.

  • Other Articles

    • Kiefer, Todd L., Sharif Halim, Andrew Wang, J. Kevin Harrison, Jeffrey Gaca, and G Chad Hughes. “Fluoroscopic characterization of surgical bioprosthetic heart valves.” Catheter Cardiovasc Interv, June 2015. https://doi.org/10.1002/ccd.25904.
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    • Kertai, Miklos D., Yen-Wei Li, Yi-Ju Li, Svati H. Shah, William E. Kraus, Manuel L. Fontes, Mark Stafford-Smith, et al. “G protein-coupled receptor kinase 5 gene polymorphisms are associated with postoperative atrial fibrillation after coronary artery bypass grafting in patients receiving β-blockers.” Circ Cardiovasc Genet, October 2014. https://doi.org/10.1161/CIRCGENETICS.113.000451.
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    • McDonagh, David L., Joseph P. Mathew, Willam D. White, Barbara Phillips-Bute, Daniel T. Laskowitz, Mihai V. Podgoreanu, Mark F. Newman, and Mark F. Neurologic Outcome Research Group. “Cognitive function after major noncardiac surgery, apolipoprotein E4 genotype, and biomarkers of brain injury.” Anesthesiology, April 2010. https://doi.org/10.1097/ALN.0b013e3181d31fd7.
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  • Conference Papers

    • Vekstein, Andrew M., Babtunde A. Yerokun, Oliver K. Jawitz, Julie W. Doberne, Jatin Anand, Jorn Karhausen, David N. Ranney, et al. “Does deeper hypothermia reduce the risk of acute kidney injury after circulatory arrest for aortic arch surgery?” In Eur J Cardiothorac Surg, 60:314–21, 2021. https://doi.org/10.1093/ejcts/ezab044.
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    • Inohara, T., P. Manandhar, A. Kosinski, S. Kohsaka, R. J. Mentz, V. H. Thourani, J. D. Carroll, et al. “Association of renin-angiotensin system inhibition with clinical outcomes in patients undergoing transcatheter aortic valve replacement: analysis from the STS/ACC TVT Registry.” In European Heart Journal, 39:1250–1250. OXFORD UNIV PRESS, 2018.
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    • Wang, Hanghang, Matthew Wagner, Ehsan Benrashid, Jeffrey Keenan, Alice Wang, David Ranney, Babatunde Yerokun, Jeffrey G. Gaca, Richard L. McCann, and G Chad Hughes. “Outcomes of Reoperation After Acute Type A Aortic Dissection: Implications for Index Repair Strategy.” In J Am Heart Assoc, Vol. 6, 2017. https://doi.org/10.1161/JAHA.117.006376.
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    • Mavroudis, Constantine, Jeffrey Gaca, and Robert M. Sade. “Can a Surgeon Refuse to Operate When an Advance Directive Limits Postoperative Care?” In Ann Thorac Surg, 102:1046–50, 2016. https://doi.org/10.1016/j.athoracsur.2016.04.062.
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    • Vavalle, John P., Patricia Cowper, James A. Nelson, Lvnne Hurwitz, G Chad Hughes, Andrew Wang, Jeffrey G. Gaca, et al. “Inpatient and Outpatient Resource Utilization in the Evaluation and Management of Patients With Aortic Stenosis Being Considered for Transcatheter Aortic Valve Replacement (TAVR).” In Circulation, Vol. 128. LIPPINCOTT WILLIAMS & WILKINS, 2013.
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    • Harskamp, R. E., J. M. Brennan, J. G. Gaca, M. E. Halkos, E. D. Peterson, S. V. Rao, J. B. Williams, R. J. De Winter, J. H. Alexander, and R. D. Lopes. “A systematic review of outcomes related to hybrid coronary revascularization in patients with multi-vessel coronary artery disease in the drug-eluting stent era.” In European Heart Journal, 34:834–834. OXFORD UNIV PRESS, 2013.
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    • Andersen, Nicholas D., Jennifer M. Hanna, Syamal D. Bhattacharya, Judson B. Williams, Jeffrey G. Gaca, Richard L. McCann, and Chad G. Hughes. “Insurance status predicts non-elective case status but not outcomes of thoracic aortic operations.” In Journal of the American College of Surgeons, 215:S45–46. Ovid Technologies (Wolters Kluwer Health), 2012. https://doi.org/10.1016/j.jamcollsurg.2012.06.136.
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    • Hughes, G Chad, Yue Zhao, J Scott Rankin, Sean O’Brien, Joseph E. Bavaria, Walter G. Wolfe, Jeffrey G. Gaca, James S. Gammie, David M. Shahian, and Peter K. Smith. “Effects of Institutional Volumes on Operative Outcomes for Combined Aortic Valve and Ascending Aortic Surgery.” In Circulation, Vol. 122. LIPPINCOTT WILLIAMS & WILKINS, 2010.
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    • Cantu, E., J. G. Gaca, D. J. Lukes, D. Palestrant, K. Baig, G. V. Gonzalez-Stawinski, W. Parker, and R. D. Davis. “Abrogation of hyperacute pulmonary xenograft dysfunction by passenger macrophage depletion.” In American Journal of Transplantation, 4:242–242. BLACKWELL MUNKSGAARD, 2004.
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    • Cantu, E., J. G. Gaca, D. J. Lukes, D. Palestrant, K. Baig, G. Gonzalez-Stawinski, W. Parker, and R. D. Davis. “Passenger pulmonary macrophages play a key role in the coagulopathy and endothelial activation associated with pulmonary xenograft dysfunction.” In Xenotransplantation, 10:487–487. BLACKWELL MUNKSGAARD, 2003.
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    • Cantu, E., J. G. Gaca, F. J. Lukes, D. Palestrant, K. Baig, G. Gonzalez-Stawinski, W. Parker, and R. D. Davis. “Depletion of porcine pulmonary intravascular macrophages attenuates hyperacute pulmonary xenograft dysfunction.” In Xenotransplantation, 10:487–487. BLACKWELL MUNKSGAARD, 2003.
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    • Cantu, E., S. Gibson, A. Wyse, C. Lau, J. G. Gaca, G. Gonzalez-Stawinski, K. Baig, T. Nichols, W. Parker, and R. D. Davis. “Role of porcine von Willebrand factor in pulmonary xenograft injury.” In Xenotransplantation, 10:482–482. BLACKWELL MUNKSGAARD, 2003.
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    • Gaca, J. G., D. H. Harpole, T. A. D’Amico, T. Pappas, H. F. Seigler, W. G. Wolfe, and S. Tyler. “Pathologic nodal status predicts disease-free survival after neoadjuvant chemoradiation for gastroesophageal junction carcinoma.” In Gastroenterology, 123:1–2. W B SAUNDERS CO, 2002.
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