Scholars@Duke
Jeffrey Robert Petrella

Jeffrey Robert Petrella

Professor of Radiology
Radiology, Neuroradiology
jeffrey.petrella@duke.edu
Box 3808 Med Ctr, Durham, NC 27710
1527 Hosp North, Durham, NC 27710

Featured Works

Effects of donepezil on cortical activation in mild cognitive impairment: a pilot double-blind placebo-controlled trial using functional MR imaging.

Journal article AJNR Am J Neuroradiol · February 2009 Featured Work BACKGROUND AND PURPOSE: Cholinesterase-inhibitor therapy is approved for treatment of Alzheimer disease; however, application in patients with mild cognitive impairment (MCI) is still under active investigation. The purpose of this study was to determine t ... Full text Link to item Cite

Imaging genetics of brain longevity and mental wellness: the next frontier?

Journal article Radiology · January 2008 Featured Work The advent of new "omics" technologies (genomics, proteomics, and metabolomics) has ushered in a new era of biomedical discovery that is already affecting every field of medicine. With the rapid growth of the older population worldwide, there is great inte ... Full text Link to item Cite

Prognostic value of posteromedial cortex deactivation in mild cognitive impairment.

Journal article PLoS One · October 31, 2007 Featured Work BACKGROUND: Normal subjects deactivate specific brain regions, notably the posteromedial cortex (PMC), during many tasks. Recent cross-sectional functional magnetic resonance imaging (fMRI) data suggests that deactivation during memory tasks is impaired in ... Full text Link to item Cite

Cortical deactivation in mild cognitive impairment: high-field-strength functional MR imaging.

Journal article Radiology · October 2007 Featured Work PURPOSE: To prospectively identify brain regions in which task-related changes in activation during a memory encoding task, measured with functional magnetic resonance (MR) imaging, correlate with degree of memory impairment across Alzheimer disease (AD), ... Full text Link to item Cite

Hippocampal atrophy confounds template-based functional MR imaging measures of hippocampal activation in patients with mild cognitive impairment.

Journal article AJNR Am J Neuroradiol · September 2006 Featured Work BACKGROUND AND PURPOSE: Functional MR imaging has been used to study patterns of hippocampal activation that distinguish pathologic from normal memory loss in the elderly population. Our objective was to assess whether hippocampal atrophy confounds measure ... Link to item Cite

Preoperative functional MR imaging localization of language and motor areas: effect on therapeutic decision making in patients with potentially resectable brain tumors.

Journal article Radiology · September 2006 Featured Work PURPOSE: To prospectively evaluate the effect of preoperative functional magnetic resonance (MR) imaging localization of language and motor areas on therapeutic decision making in patients with potentially resectable brain tumors. MATERIALS AND METHODS: Th ... Full text Link to item Cite

Mild cognitive impairment: evaluation with 4-T functional MR imaging.

Journal article Radiology · July 2006 Featured Work PURPOSE: To prospectively assess abnormalities in brain activation patterns during encoding and retrieval in subjects with mild cognitive impairment by using 4-T functional magnetic resonance (MR) imaging. MATERIALS AND METHODS: The institutional review bo ... Full text Link to item Cite

Accuracy of spatial normalization of the hippocampus: implications for fMRI research in memory disorders.

Journal article Neuroimage · June 2006 Featured Work Functional magnetic resonance imaging (fMRI) studies in memory impairment have detected functional alterations in medial temporal lobe (MTL) structures, notably the hippocampus. Many of these studies employ spatial normalization to place subjects in a stan ... Full text Link to item Cite

Current status of functional MR imaging, perfusion-weighted imaging, and diffusion-tensor imaging in Alzheimer's disease diagnosis and research.

Journal article Neuroimaging Clin N Am · November 2005 Featured Work Advanced MR techniques, such as functional MR imaging, perfusion-weighted imaging, and diffusion-tensor imaging, offer the capability of detecting early functional, hemodynamic, and microstructural alterations in Alzheimer's disease before gross anatomic a ... Full text Link to item Cite

Increasing memory load modulates regional brain activity in older adults as measured by fMRI.

Journal article J Neuropsychiatry Clin Neurosci · 2005 Featured Work Several recent studies using functional magnetic resonance imaging (fMRI) during recognition memory tests have suggested that the ability to neuromodulate as a function of cognitive demand may be impaired in older adults due to age-related cell loss and ne ... Full text Link to item Cite

In vivo amyloid imaging in Alzheimer's disease.

Journal article Neuroradiology · February 2004 Featured Work Targeted approaches to therapy for Alzheimer's disease have evolved based on detailed understanding of the genetic, molecular biologic, and neuropathologic basis of the disease. Given the potential for greater treatment efficacy in the earlier stages of th ... Full text Link to item Cite

Neuroimaging and early diagnosis of Alzheimer disease: a look to the future.

Journal article Radiology · February 2003 Featured Work Alzheimer disease (AD), a progressive neurodegenerative disorder, is the most common cause of dementia in the elderly. Current consensus statements have emphasized the need for early recognition and the fact that a diagnosis of AD can be made with high acc ... Full text Link to item Cite

Prefrontal activation patterns in subjects at risk for Alzheimer disease.

Journal article Am J Geriatr Psychiatry · 2002 Featured Work Link to item Cite

MR perfusion imaging of the brain: techniques and applications.

Journal article AJR Am J Roentgenol · July 2000 Featured Work Full text Link to item Cite

Age-related vasodilatory response to acetazolamide challenge in healthy adults: a dynamic contrast-enhanced MR study.

Journal article AJNR Am J Neuroradiol · January 1998 Featured Work PURPOSE: We examined age-related changes in baseline regional cerebral blood volume (rCBV) and response to acetazolamide stimulation by using dynamic contrast-enhanced MR imaging. METHODS: Thirty healthy volunteers ranging widely in age (23 to 82 years) we ... Link to item Cite

Assessment of whole-brain vasodilatory capacity with acetazolamide challenge at 1.5 T using dynamic contrast imaging with frequency-shifted burst.

Journal article AJNR Am J Neuroradiol · 1997 Featured Work PURPOSE: To determine whether whole-brain acetazolamide-induced changes in regional cerebral blood volume (rCBV) can be assessed on a conventional gradient 1.5-T MR system using 3-D dynamic susceptibility contrast-enhanced MR imaging. METHODS: A 3-D freque ... Link to item Cite