Scholars@Duke
Jennifer Leigh Ingram

Jennifer Leigh Ingram

Associate Professor in Medicine
Medicine, Pulmonary, Allergy, and Critical Care Medicine
Duke Box 2641, Durham, NC 27710
201 MSRB1 Bldg, Durham, NC 27710

Scholarly Works - Conferences

D21-05 Leptin- and Oxidative Stress-induced Periostin Secretion in Airway Fibroblasts Is Associated With 129XeMRI-localized Abnormal Airway Regions in Asthma With Comorbid Obesity

Conference American Journal of Respiratory and Critical Care Medicine · May 1, 2026 AbstractRationaleObesity, a prevalent comorbidity of asthma, worsens disease severity and blunts responses to asthma therapies. ... Full text Cite

B22-04 Oxidant Stress Associates With Regional Ventilation Impairment in Comorbid Obesity and Asthma

Conference American Journal of Respiratory and Critical Care Medicine · May 1, 2026 AbstractRationaleObesity increases the severity of asthma and modifies airway pathobiology, contributing to a lack of responsiv ... Full text Cite

129Xe Gas Exchange MRI in Obesity-associated Asthma: Clinical Correlates and Regional Patterns

Conference American Journal of Respiratory and Critical Care Medicine · May 1, 2025 AbstractRationale. The complex interplay of factors contributing to the pathobiology of obesity-associated asthma is poorly understood. Advancing understanding of the unique disease mechanisms driving gas ... Full text Cite

Impact of Sarcopenic Obesity on Pulmonary Responses to Hyperoxia

Conference American Journal of Respiratory and Critical Care Medicine · May 1, 2025 AbstractBackground: Sarcopenic obesity (SO) is the coexistence of reduced muscle mass and function that occurs in aging and excess body fat. SO is linked to a higher incidence of lung disease than obesity ... Full text Cite

Taurine Protects Against Ozone-induced Airway Hyperresponsiveness and Oxidative Stress in Paraoxonase 1 Knockout Mice

Conference American Journal of Respiratory and Critical Care Medicine · May 1, 2025 AbstractRationale: Ozone (O3) is a common air pollutant that exacerbates asthma and other respiratory diseases by increasing oxidative stress. The paraoxonase (PON) family, which includes PON1, PON2, and ... Full text Cite

Pulmonary Regional Differences Highlight Profibrotic Airway Epithelial Cell Signaling in Obese Asthma

Conference American Journal of Respiratory and Critical Care Medicine · May 1, 2025 AbstractRationale: Obesity increases the severity of asthma and modifies airway pathobiology, contributing to lack of responsiveness to standard asthma therapies. The mechanisms driving altered lung funct ... Full text Cite

Oxidant-induced Alteration of Fibrotic Markers in Airway Fibroblasts Isolated From Patients With Asthma and Obesity

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · May 1, 2024 Link to item Cite

Paraoxonase 2 Mitigates Mitochondrial Oxidative Stress in Airway Epithelial Cells

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · May 1, 2024 Link to item Cite

Vertical Sleeve Gastrectomy in Chronically Allergen-Challenged Obese Mice Increases Airway Hyperresponsiveness

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · May 1, 2021 Link to item Cite

Vertical Sleeve Gastrectomy Increased PPAR. Expression in Obese Mice Challenged with House Dust Mite

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · May 1, 2021 Link to item Cite

Vertical Sleeve Gastrectomy Increased PPARĪ³ Expression in Obese Mice Challenged with House Dust Mite

Conference TP9. TP009 MECHANISTIC AND TRANSLATIONAL ASTHMA STUDIES · May 2021 Full text Cite

Deficiency in Paraoxonase 2 Increases Airway Hyper Responsiveness After Ozone Exposure in Mice

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · 2020 Link to item Cite

Glucagon Like Peptide 1 Attenuates Airway Hyperresponsiveness in a Mouse Model of Obese Allergic Asthma

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · 2020 Link to item Cite

Physiologic response to chronic house dust mite exposure in mice is dependent on lot characteristics.

Conference J Allergy Clin Immunol · November 2019 Physiological responses to HDM extracts are variable. To increase the transparency and reproducibility of published work, lot numbers, concentration of extract components, and methods for dose normalization need to be thoroughly reported. ... Full text Link to item Cite

Characterization of Paraoxonases in Mice with Obese Allergic Asthma

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2018 Link to item Cite

Vertical Sleeve Gastrectomy in Allergen-Challenged Obese Mice Is Associated with Reduced Airway Resistance and Fibrosis

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2018 Link to item Cite

An in Vitro Model of Airway Fibroblast Functions to Assess Airway Remodeling in Asthma

Conference IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL · August 1, 2017 Link to item Cite

Modeling Human Lung Fibroblast Responses in Asthma and Airway Disease

Conference IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL · June 1, 2017 Link to item Cite

Interleukin-17 And Leptin Contribute To Airway Fibrosis And Altered Interleukin-13 Receptor Expression In Obese Asthma

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2016 Link to item Cite

An In Vivo Model Of Human Airways For Investigating Fibrosis

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2016 Link to item Cite

Increased Tissue Eosinophilia In Obese Asthma May Be Due To Decreased Surfactant Protein-A Levels

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2015 Link to item Cite

Leptin Augments Interleukin-13-Induced Eotaxin-1 And Eotaxin-3 Production By Airway Fibroblasts In Asthma

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2015 Link to item Cite

Asthmatic Airway Fibroblasts: Tgf beta Receptor Signaling Is Up-Regulated After Obese Visceral Adipose Exosome Exposure

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2015 Link to item Cite

In Vivo Evidence In A Xenograft Model For Asthmatic Epithelium Driving Airway Remodeling

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2015 Link to item Cite

IL-13 Induces Procollagen 1 mRNA Expression in Human Airway Fibroblasts in Asthma

Conference Journal of Allergy and Clinical Immunology · February 2010 Full text Cite