Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., University of Basel 2003
  • M.S., University of Wisconsin at Madison 1998
• Research
• 

  Selected Grants

  • Advancing Genomic Technologies to Combat Infectious Disease: Mapping Dynamics within Single Cells, Individual Hosts, and Global Populations 2019 - 2024
  • Evolution of Cryptococcus neoformans Strains from Patients with HIV/AIDS awarded by National Institutes of Health 2011 - 2023
  • Evolution of Cryptococcus neoformans Strains from Patients with HIV/AIDS awarded by National Institutes of Health 2011 - 2020
  • Pathobiology of C. neoformans in the Central Nervous System awarded by National Institutes of Health 2014 - 2020
  • Regulation of Innate Immunity by Virulence Factors awarded by National Institutes of Health 2005 - 2007
  • Boosting innate immunity against Yersinia pestis 2006 - 2007
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Ponzio, Vinicius, Yuan Chen, Anderson Messias Rodrigues, Jennifer L. Tenor, Dena L. Toffaletti, José Osmar Medina-Pestana, Arnaldo Lopes Colombo, and John R. Perfect. “Genotypic diversity and clinical outcome of cryptococcosis in renal transplant recipients in Brazil..” Emerg Microbes Infect 8, no. 1 (2019): 119–29. https://doi.org/10.1080/22221751.2018.1562849.
       Full Text  Link to Item
    • Shaw, Karen Joy, Wiley A. Schell, Jonathan Covel, Gisele Duboc, C. Giamberardino, Mili Kapoor, Molly Moloney, et al. “In Vitro and In Vivo Evaluation of APX001A/APX001 and Other Gwt1 Inhibitors against Cryptococcus..” Antimicrob Agents Chemother 62, no. 8 (August 2018). https://doi.org/10.1128/AAC.00523-18.
       Full Text  Link to Item
    • Miao, Yi, Jennifer L. Tenor, Dena L. Toffaletti, Stacey A. Maskarinec, Jiuyu Liu, Richard E. Lee, John R. Perfect, and Richard G. Brennan. “Structural and In Vivo Studies on Trehalose-6-Phosphate Synthase from Pathogenic Fungi Provide Insights into Its Catalytic Mechanism, Biological Necessity, and Potential for Novel Antifungal Drug Design..” Mbio 8, no. 4 (July 25, 2017). https://doi.org/10.1128/mBio.00643-17.
       Full Text  Link to Item
    • Desjardins, Christopher A., Charles Giamberardino, Sean M. Sykes, Chen-Hsin Yu, Jennifer L. Tenor, Yuan Chen, Timothy Yang, et al. “Population genomics and the evolution of virulence in the fungal pathogen Cryptococcus neoformans..” Genome Res 27, no. 7 (July 2017): 1207–19. https://doi.org/10.1101/gr.218727.116.
       Full Text  Link to Item
    • Chen, Yuan, Rhys A. Farrer, Charles Giamberardino, Sharadha Sakthikumar, Alexander Jones, Timothy Yang, Jennifer L. Tenor, et al. “Microevolution of Serial Clinical Isolates of Cryptococcus neoformans var. grubii and C. gattii..” Mbio 8, no. 2 (March 7, 2017). https://doi.org/10.1128/mBio.00166-17.
       Full Text  Open Access Copy  Link to Item
    • Perfect, John R., Jennifer L. Tenor, Yi Miao, and Richard G. Brennan. “Trehalose pathway as an antifungal target..” Virulence 8, no. 2 (February 17, 2017): 143–49. https://doi.org/10.1080/21505594.2016.1195529.
       Full Text  Link to Item
    • Tenor, Jennifer L., Stefan H. Oehlers, Jialu L. Yang, David M. Tobin, and John R. Perfect. “Live Imaging of Host-Parasite Interactions in a Zebrafish Infection Model Reveals Cryptococcal Determinants of Virulence and Central Nervous System Invasion..” Mbio 6, no. 5 (September 29, 2015): e01425–e01415. https://doi.org/10.1128/mBio.01425-15.
       Full Text  Open Access Copy  Link to Item
    • Chen, Y., D. L. Toffaletti, J. L. Tenor, A. P. Litvintseva, C. Fang, T. G. Mitchell, T. R. McDonald, et al. “The Cryptococcus neoformans transcriptome at the site of human meningitis.” Mbio 5, no. 1 (February 4, 2014). https://doi.org/10.1128/mBio.01087-13.
       Full Text
    • Frazzitta, Aubrey E., Haily Vora, Michael S. Price, Jennifer L. Tenor, Marisol Betancourt-Quiroz, Dena L. Toffaletti, Nan Cheng, and John R. Perfect. “Nitrogen source-dependent capsule induction in human-pathogenic cryptococcus species..” Eukaryot Cell 12, no. 11 (November 2013): 1439–50. https://doi.org/10.1128/EC.00169-13.
       Full Text  Link to Item
    • Fang, Wei, Michael S. Price, Dena L. Toffaletti, Jennifer Tenor, Marisol Betancourt-Quiroz, Jennifer L. Price, Wei-hua Pan, Wan-qing Liao, and John R. Perfect. “Pleiotropic effects of deubiquitinating enzyme Ubp5 on growth and pathogenesis of Cryptococcus neoformans..” Plos One 7, no. 6 (2012). https://doi.org/10.1371/journal.pone.0038326.
       Full Text  Link to Item
    • Lee, Anthony, Dena L. Toffaletti, Jennifer Tenor, Erik J. Soderblom, J Will Thompson, M Arthur Moseley, Michael Price, and John R. Perfect. “Survival defects of Cryptococcus neoformans mutants exposed to human cerebrospinal fluid result in attenuated virulence in an experimental model of meningitis..” Infect Immun 78, no. 10 (October 2010): 4213–25. https://doi.org/10.1128/IAI.00551-10.
       Full Text  Link to Item
    • Bolz, Devin D., Jennifer L. Tenor, and Alejandro Aballay. “A conserved PMK-1/p38 MAPK is required in caenorhabditis elegans tissue-specific immune response to Yersinia pestis infection..” J Biol Chem 285, no. 14 (April 2, 2010): 10832–40. https://doi.org/10.1074/jbc.M109.091629.
       Full Text  Link to Item
    • Tenor, Jennifer L., and Alejandro Aballay. “A conserved Toll-like receptor is required for Caenorhabditis elegans innate immunity..” Embo Rep 9, no. 1 (January 2008): 103–9. https://doi.org/10.1038/sj.embor.7401104.
       Full Text  Link to Item
    • Tenor, Jennifer L., Beth A. McCormick, Frederick M. Ausubel, and Alejandro Aballay. “Caenorhabditis elegans-based screen identifies Salmonella virulence factors required for conserved host-pathogen interactions..” Curr Biol 14, no. 11 (June 8, 2004): 1018–24. https://doi.org/10.1016/j.cub.2004.05.050.
       Full Text  Link to Item

  • Conference Papers

    • Tenor, J. L. “Report from the 8th International Conference on Cryptococcus and Cryptococcosis (ICCC 2011): Charleston, SC, USA, 1-5 May 2011.” In Journal of Invasive Fungal Infections, 5:60–62, 2011.

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.