Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., University of Basel 2003
  • M.S., University of Wisconsin at Madison 1998
• Research
• 

  Selected Grants

  • Evolution of Cryptococcus neoformans Strains from Patients with HIV/AIDS awarded by National Institutes of Health 2011 - 2020
  • Pathobiology of C. neoformans in the Central Nervous System awarded by National Institutes of Health 2014 - 2019
  • Regulation of Innate Immunity by Virulence Factors awarded by National Institutes of Health 2005 - 2007
  • Boosting innate immunity against Yersinia pestis awarded by Southeast Regional Center of Excellence in Biodefense and Emerging Infections 2006 - 2007
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Ponzio, V, Chen, Y, Rodrigues, AM, Tenor, JL, Toffaletti, DL, Medina-Pestana, JO, Colombo, AL, and Perfect, JR. "Genotypic diversity and clinical outcome of cryptococcosis in renal transplant recipients in Brazil." Emerging Microbes & Infections 8, no. 1 (January 2019): 119-129.  Full Text
    • Shaw, KJ, Schell, WA, Covel, J, Duboc, G, Giamberardino, C, Kapoor, M, Moloney, M, Soltow, QA, Tenor, JL, Toffaletti, DL, Trzoss, M, Webb, P, and Perfect, JR. "In Vitro and In Vivo Evaluation of APX001A/APX001 and Other Gwt1 Inhibitors against Cryptococcus." Antimicrobial Agents and Chemotherapy 62, no. 8 (August 2018).  Full Text
    • Miao, Y, Tenor, JL, Toffaletti, DL, Maskarinec, SA, Liu, J, Lee, RE, Perfect, JR, and Brennan, RG. "Structural and In Vivo Studies on Trehalose-6-Phosphate Synthase from Pathogenic Fungi Provide Insights into Its Catalytic Mechanism, Biological Necessity, and Potential for Novel Antifungal Drug Design." Mbio 8, no. 4 (July 25, 2017).  Full Text
    • Desjardins, CA, Giamberardino, C, Sykes, SM, Yu, C-H, Tenor, JL, Chen, Y, Yang, T, Jones, AM, Sun, S, Haverkamp, MR, Heitman, J, Litvintseva, AP, Perfect, JR, and Cuomo, CA. "Population genomics and the evolution of virulence in the fungal pathogen Cryptococcus neoformans." Genome Research 27, no. 7 (July 2017): 1207-1219.  Full Text
    • Chen, Y, Farrer, RA, Giamberardino, C, Sakthikumar, S, Jones, A, Yang, T, Tenor, JL, Wagih, O, Van Wyk, M, Govender, NP, Mitchell, TG, Litvintseva, AP, Cuomo, CA, and Perfect, JR. "Microevolution of Serial Clinical Isolates of Cryptococcus neoformans var. grubii and C. gattii." Mbio 8, no. 2 (March 7, 2017).  Full Text  Open Access Copy
    • Perfect, JR, Tenor, JL, Miao, Y, and Brennan, RG. "Trehalose pathway as an antifungal target." Virulence 8, no. 2 (February 2017): 143-149. (Review)  Full Text
    • Tenor, JL, Oehlers, SH, Yang, JL, Tobin, DM, and Perfect, JR. "Live Imaging of Host-Parasite Interactions in a Zebrafish Infection Model Reveals Cryptococcal Determinants of Virulence and Central Nervous System Invasion." Mbio 6, no. 5 (September 29, 2015): e01425-e01415.  Full Text  Open Access Copy
    • Chen, Y, Toffaletti, DL, Tenor, JL, Litvintseva, AP, Fang, C, Mitchell, TG, McDonald, TR, Nielsen, K, Boulware, DR, Bicanic, T, and Perfect, JR. "The Cryptococcus neoformans transcriptome at the site of human meningitis." Mbio 5, no. 1 (February 4, 2014).  Full Text
    • Frazzitta, AE, Vora, H, Price, MS, Tenor, JL, Betancourt-Quiroz, M, Toffaletti, DL, Cheng, N, and Perfect, JR. "Nitrogen source-dependent capsule induction in human-pathogenic cryptococcus species." Eukaryotic Cell 12, no. 11 (November 2013): 1439-1450.  Full Text
    • Fang, W, Price, MS, Toffaletti, DL, Tenor, J, Betancourt-Quiroz, M, Price, JL, Pan, W-H, Liao, W-Q, and Perfect, JR. "Pleiotropic effects of deubiquitinating enzyme Ubp5 on growth and pathogenesis of Cryptococcus neoformans." PLoS One 7, no. 6 (2012): e38326-.  Full Text  Link to Item
    • Lee, A, Toffaletti, DL, Tenor, J, Soderblom, EJ, Thompson, JW, Moseley, MA, Price, M, and Perfect, JR. "Survival defects of Cryptococcus neoformans mutants exposed to human cerebrospinal fluid result in attenuated virulence in an experimental model of meningitis." Infection and Immunity 78, no. 10 (October 2010): 4213-4225.  Full Text
    • Bolz, DD, Tenor, JL, and Aballay, A. "A conserved PMK-1/p38 MAPK is required in caenorhabditis elegans tissue-specific immune response to Yersinia pestis infection." The Journal of Biological Chemistry 285, no. 14 (April 2010): 10832-10840.  Full Text
    • Tenor, JL, and Aballay, A. "A conserved Toll-like receptor is required for Caenorhabditis elegans innate immunity." Embo Reports 9, no. 1 (January 2008): 103-109.  Full Text
    • Tenor, JL, McCormick, BA, Ausubel, FM, and Aballay, A. "Caenorhabditis elegans-based screen identifies Salmonella virulence factors required for conserved host-pathogen interactions." Current Biology : Cb 14, no. 11 (June 2004): 1018-1024.  Full Text

  • Conference Papers

    • Tenor, JL. "Report from the 8th International Conference on Cryptococcus and Cryptococcosis (ICCC 2011): Charleston, SC, USA, 1-5 May 2011." December 16, 2011.

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