Jennifer L Tenor
Assistant Professor in Medicine
Current Appointments & Affiliations
- Assistant Professor in Medicine, Medicine, Infectious Diseases, Medicine 2021
Contact Information
- 303 Research Drive, 337/ Sands Bldg, Durham, NC 27710
- Box 102359, 303 Research Drive, Sands Building, Room, Durham, NC 27710
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jennifer.tenor@duke.edu
(919) 681-6276
- Background
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Education, Training, & Certifications
- Ph.D., University of Basel (Switzerland) 2003
- M.S., University of Wisconsin - Madison 1998
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Previous Appointments & Affiliations
- Assistant Professor in Medicine, Medicine, Infectious Diseases, Medicine 2018 - 2020
- Research
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Selected Grants
- Evolution of Cryptococcus neoformans Strains from Patients with HIV/AIDS awarded by National Institutes of Health 2011 - 2023
- Advancing Genomic Technologies to Combat Infectious Disease: Mapping Dynamics within Single Cells, Individual Hosts, and Global Populations (U19) awarded by Broad Institute 2019 - 2023
- AM-2-19 Efficacy Testing in a Mouse Model of Cryptococcosis awarded by Sfunga Therapeutics 2022
- Wellcome Trust subaward UK Liverpool awarded by University of Liverpool 2021
- Pathobiology of C. neoformans in the Central Nervous System awarded by National Institutes of Health 2014 - 2020
- Regulation of Innate Immunity by Virulence Factors awarded by National Institutes of Health 2005 - 2007
- Boosting innate immunity against Yersinia pestis awarded by Southeast Regional Center of Excellence in Biodefense and Emerging Infections 2006 - 2007
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Giamberardino, Charles D., Wiley A. Schell, Jennifer L. Tenor, Dena L. Toffaletti, Julia R. Palmucci, Choiselle Marius, Jane-Valeriane K. Boua, et al. “Efficacy of APX2039 in a Rabbit Model of Cryptococcal Meningitis.” Mbio 13, no. 6 (December 20, 2022): e0234722. https://doi.org/10.1128/mbio.02347-22.Full Text Link to Item
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Sephton-Clark, Poppy, Jennifer L. Tenor, Dena L. Toffaletti, Nancy Meyers, Charles Giamberardino, Síle F. Molloy, Julia R. Palmucci, et al. “Genomic Variation across a Clinical Cryptococcus Population Linked to Disease Outcome.” Mbio 13, no. 6 (December 20, 2022): e0262622. https://doi.org/10.1128/mbio.02626-22.Full Text Link to Item
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Holcomb, Zachary E., Julie M. Steinbrink, Aimee K. Zaas, Marisol Betancourt, Jennifer L. Tenor, Dena L. Toffaletti, J Andrew Alspaugh, John R. Perfect, and Micah T. McClain. “Transcriptional Profiles Elucidate Differential Host Responses to Infection with Cryptococcus neoformans and Cryptococcus gattii.” J Fungi (Basel) 8, no. 5 (April 22, 2022). https://doi.org/10.3390/jof8050430.Full Text Link to Item
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Yu, Chen-Hsin, Poppy Sephton-Clark, Jennifer L. Tenor, Dena L. Toffaletti, Charles Giamberardino, Miriam Haverkamp, Christina A. Cuomo, and John R. Perfect. “Gene Expression of Diverse Cryptococcus Isolates during Infection of the Human Central Nervous System.” Mbio 12, no. 6 (December 21, 2021): e0231321. https://doi.org/10.1128/mBio.02313-21.Full Text Link to Item
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Fu, Man Shun, Livia C. Liporagi-Lopes, Samuel R. Dos Santos, Jennifer L. Tenor, John R. Perfect, Christina A. Cuomo, and Arturo Casadevall. “Amoeba Predation of Cryptococcus neoformans Results in Pleiotropic Changes to Traits Associated with Virulence.” Mbio 12, no. 2 (April 27, 2021). https://doi.org/10.1128/mBio.00567-21.Full Text Link to Item
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Oliveira, Lana Sarita de Souza, Luciana Magalhães Pinto, Mariana Araújo Paulo de Medeiros, Dena L. Toffaletti, Jennifer L. Tenor, Tânia Fraga Barros, Rejane Pereira Neves, et al. “Comparison of Cryptococcus gattii/neoformans Species Complex to Related Genera (Papiliotrema and Naganishia) Reveal Variances in Virulence Associated Factors and Antifungal Susceptibility.” Front Cell Infect Microbiol 11 (2021): 642658. https://doi.org/10.3389/fcimb.2021.642658.Full Text Link to Item
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Thanh, Lam Tuan, Dena L. Toffaletti, Jennifer L. Tenor, Charles Giamberardino, Gregory D. Sempowski, Yohannes Asfaw, Hai Trieu Phan, et al. “Assessing the virulence of Cryptococcus neoformans causing meningitis in HIV infected and uninfected patients in Vietnam.” Med Mycol 58, no. 8 (November 10, 2020): 1149–61. https://doi.org/10.1093/mmy/myaa013.Full Text Link to Item
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Yu, Chen-Hsin, Yuan Chen, Christopher A. Desjardins, Jennifer L. Tenor, Dena L. Toffaletti, Charles Giamberardino, Anastasia Litvintseva, John R. Perfect, and Christina A. Cuomo. “Landscape of gene expression variation of natural isolates of Cryptococcus neoformans in response to biologically relevant stresses.” Microb Genom 6, no. 1 (January 2020). https://doi.org/10.1099/mgen.0.000319.Full Text Link to Item
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So, Yee-Seul, Shinae Maeng, Dong-Hoon Yang, Hyelim Kim, Kyung-Tae Lee, Seong-Ryong Yu, Jennifer L. Tenor, et al. “Regulatory Mechanism of the Atypical AP-1-Like Transcription Factor Yap1 in Cryptococcus neoformans.” Msphere 4, no. 6 (November 20, 2019). https://doi.org/10.1128/mSphere.00785-19.Full Text Link to Item
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Ponzio, Vinicius, Yuan Chen, Anderson Messias Rodrigues, Jennifer L. Tenor, Dena L. Toffaletti, José Osmar Medina-Pestana, Arnaldo Lopes Colombo, and John R. Perfect. “Genotypic diversity and clinical outcome of cryptococcosis in renal transplant recipients in Brazil.” Emerg Microbes Infect 8, no. 1 (2019): 119–29. https://doi.org/10.1080/22221751.2018.1562849.Full Text Link to Item
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Shaw, Karen Joy, Wiley A. Schell, Jonathan Covel, Gisele Duboc, C. Giamberardino, Mili Kapoor, Molly Moloney, et al. “In Vitro and In Vivo Evaluation of APX001A/APX001 and Other Gwt1 Inhibitors against Cryptococcus.” Antimicrob Agents Chemother 62, no. 8 (August 2018). https://doi.org/10.1128/AAC.00523-18.Full Text Link to Item
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Miao, Yi, Jennifer L. Tenor, Dena L. Toffaletti, Stacey A. Maskarinec, Jiuyu Liu, Richard E. Lee, John R. Perfect, and Richard G. Brennan. “Structural and In Vivo Studies on Trehalose-6-Phosphate Synthase from Pathogenic Fungi Provide Insights into Its Catalytic Mechanism, Biological Necessity, and Potential for Novel Antifungal Drug Design.” Mbio 8, no. 4 (July 25, 2017). https://doi.org/10.1128/mBio.00643-17.Full Text Link to Item
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Desjardins, Christopher A., Charles Giamberardino, Sean M. Sykes, Chen-Hsin Yu, Jennifer L. Tenor, Yuan Chen, Timothy Yang, et al. “Population genomics and the evolution of virulence in the fungal pathogen Cryptococcus neoformans.” Genome Res 27, no. 7 (July 2017): 1207–19. https://doi.org/10.1101/gr.218727.116.Full Text Link to Item
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Chen, Yuan, Rhys A. Farrer, Charles Giamberardino, Sharadha Sakthikumar, Alexander Jones, Timothy Yang, Jennifer L. Tenor, et al. “Microevolution of Serial Clinical Isolates of Cryptococcus neoformans var. grubii and C. gattii.” Mbio 8, no. 2 (March 7, 2017). https://doi.org/10.1128/mBio.00166-17.Full Text Open Access Copy Link to Item
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Perfect, John R., Jennifer L. Tenor, Yi Miao, and Richard G. Brennan. “Trehalose pathway as an antifungal target.” Virulence 8, no. 2 (February 17, 2017): 143–49. https://doi.org/10.1080/21505594.2016.1195529.Full Text Link to Item
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Tenor, Jennifer L., Stefan H. Oehlers, Jialu L. Yang, David M. Tobin, and John R. Perfect. “Live Imaging of Host-Parasite Interactions in a Zebrafish Infection Model Reveals Cryptococcal Determinants of Virulence and Central Nervous System Invasion.” Mbio 6, no. 5 (September 29, 2015): e01425–e01415. https://doi.org/10.1128/mBio.01425-15.Full Text Open Access Copy Link to Item
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Chen, Y., D. L. Toffaletti, J. L. Tenor, A. P. Litvintseva, C. Fang, T. G. Mitchell, T. R. McDonald, et al. “The Cryptococcus neoformans transcriptome at the site of human meningitis.” Mbio 5, no. 1 (February 4, 2014). https://doi.org/10.1128/mBio.01087-13.Full Text
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Frazzitta, Aubrey E., Haily Vora, Michael S. Price, Jennifer L. Tenor, Marisol Betancourt-Quiroz, Dena L. Toffaletti, Nan Cheng, and John R. Perfect. “Nitrogen source-dependent capsule induction in human-pathogenic cryptococcus species.” Eukaryot Cell 12, no. 11 (November 2013): 1439–50. https://doi.org/10.1128/EC.00169-13.Full Text Link to Item
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Fang, Wei, Michael S. Price, Dena L. Toffaletti, Jennifer Tenor, Marisol Betancourt-Quiroz, Jennifer L. Price, Wei-hua Pan, Wan-qing Liao, and John R. Perfect. “Pleiotropic effects of deubiquitinating enzyme Ubp5 on growth and pathogenesis of Cryptococcus neoformans.” Plos One 7, no. 6 (2012): e38326. https://doi.org/10.1371/journal.pone.0038326.Full Text Link to Item
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Lee, Anthony, Dena L. Toffaletti, Jennifer Tenor, Erik J. Soderblom, J Will Thompson, M Arthur Moseley, Michael Price, and John R. Perfect. “Survival defects of Cryptococcus neoformans mutants exposed to human cerebrospinal fluid result in attenuated virulence in an experimental model of meningitis.” Infect Immun 78, no. 10 (October 2010): 4213–25. https://doi.org/10.1128/IAI.00551-10.Full Text Link to Item
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Bolz, Devin D., Jennifer L. Tenor, and Alejandro Aballay. “A conserved PMK-1/p38 MAPK is required in caenorhabditis elegans tissue-specific immune response to Yersinia pestis infection.” J Biol Chem 285, no. 14 (April 2, 2010): 10832–40. https://doi.org/10.1074/jbc.M109.091629.Full Text Link to Item
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Tenor, Jennifer L., and Alejandro Aballay. “A conserved Toll-like receptor is required for Caenorhabditis elegans innate immunity.” Embo Rep 9, no. 1 (January 2008): 103–9. https://doi.org/10.1038/sj.embor.7401104.Full Text Link to Item
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Tenor, Jennifer L., Beth A. McCormick, Frederick M. Ausubel, and Alejandro Aballay. “Caenorhabditis elegans-based screen identifies Salmonella virulence factors required for conserved host-pathogen interactions.” Curr Biol 14, no. 11 (June 8, 2004): 1018–24. https://doi.org/10.1016/j.cub.2004.05.050.Full Text Link to Item
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Nguyen, Kien T., Jennifer Tenor, Hansruedi Stettler, Lieu T. Nguyen, Liem D. Nguyen, and Charles J. Thompson. “Colonial differentiation in Streptomyces coelicolor depends on translation of a specific codon within the adpA gene.” J Bacteriol 185, no. 24 (December 2003): 7291–96. https://doi.org/10.1128/JB.185.24.7291-7296.2003.Full Text Link to Item
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Kelemen, G. H., P. H. Viollier, J. Tenor, L. Marri, M. J. Buttner, and C. J. Thompson. “A connection between stress and development in the multicellular prokaryote Streptomyces coelicolor A3(2).” Mol Microbiol 40, no. 4 (May 2001): 804–14. https://doi.org/10.1046/j.1365-2958.2001.02417.x.Full Text Link to Item
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Conference Papers
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Tenor, J. L. “Report from the 8th International Conference on Cryptococcus and Cryptococcosis (ICCC 2011): Charleston, SC, USA, 1-5 May 2011.” In Journal of Invasive Fungal Infections, 5:60–62, 2011.
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