Scholars@Duke
Jennifer Yunyan Zhang

Jennifer Yunyan Zhang

Professor in Dermatology
Dermatology
Duke Box 103052, Durham, NC 27710
Rm 4130, MSRB III Bldg, 3 Genome Ct, Durham, NC 27705

Featured Works

c-Jun promotes whereas JunB inhibits epidermal neoplasia.

Journal article J Invest Dermatol · May 2011 Featured Publication Deregulation of the activator protein 1 (AP1) family gene regulators has been implicated in a wide range of diseases, including cancer. In this study we report that c-Jun was activated in human squamous cell carcinoma (SCC) and coexpression of c-Jun with o ... Full text Link to item Cite

The c-Jun NH2-terminal kinase 2 plays a dominant role in human epidermal neoplasia.

Journal article Cancer Res · April 15, 2010 Featured Publication The c-Jun NH(2)-terminal kinase (JNK) signaling cascade has been implicated in a wide range of diseases, including cancer. It is unclear how different JNK proteins contribute to human cancer. Here, we report that JNK2 is activated in more than 70% of human ... Full text Link to item Cite

Tumor necrosis factor receptor 1/c-Jun-NH2-kinase signaling promotes human neoplasia.

Journal article Cancer Res · April 15, 2007 Featured Publication The tumor necrosis factor alpha receptor (TNFR1) activates downstream effectors that include the mitogen-activated protein kinase kinase 7 (MKK7)/c-Jun-NH(2)-kinase (JNK)/activator protein 1 (AP1) cascade. Here, we report that JNK is activated in a majorit ... Full text Link to item Cite

CDK4 regulation by TNFR1 and JNK is required for NF-kappaB-mediated epidermal growth control.

Journal article J Cell Biol · February 14, 2005 Featured Publication Nuclear factor kappaB (NF-kappaB) mediates homeostatic growth inhibition in the epidermis, and a loss of NF-kappaB function promotes proliferation and oncogenesis. To identify mechanisms responsible for these effects, we impaired NF-kappaB action in the ep ... Full text Link to item Cite

NF-kappaB RelA opposes epidermal proliferation driven by TNFR1 and JNK.

Journal article Genes Dev · January 1, 2004 Featured Publication NF-kappaB inhibition promotes epidermal tumorigenesis; however, whether this reflects an underlying role in homeostasis or a special case confined to neoplasia is unknown. Embryonic lethality of mice lacking NF-kappaB RelA has hindered efforts to address t ... Full text Link to item Cite

Innate inhibition of adaptive immunity: Mycobacterium tuberculosis-induced IL-6 inhibits macrophage responses to IFN-gamma.

Journal article J Immunol · November 1, 2003 Featured Publication In humans and in mice, control of the intracellular pathogen, Mycobacterium tuberculosis (Mtb), requires IFN-gamma. Although the adaptive immune response results in production of substantial amounts of IFN-gamma in response to Mtb, the immune response is u ... Full text Link to item Cite

Divergent gene regulation and growth effects by NF-kappa B in epithelial and mesenchymal cells of human skin.

Journal article Oncogene · April 3, 2003 Featured Publication NF-kappa B regulates normal and pathological processes, including neoplasia, in a tissue-context-dependent manner. In skin, NF-kappa B is implicated in epidermal homeostasis as well as in the pathogenesis of squamous cell carcinoma; however, its function i ... Full text Link to item Cite

NF-kappaB blockade and oncogenic Ras trigger invasive human epidermal neoplasia.

Journal article Nature · February 6, 2003 Featured Publication The nuclear factor NF-kappaB and oncogenic Ras can alter proliferation in epidermis, the most common site of human cancer. These proteins are implicated in epidermal squamous cell carcinoma in mice, however, the potential effects of altering their function ... Full text Link to item Cite

A linking function for the cellulose-binding protein SP85 in the spore coat of Dictyostelium discoideum.

Journal article J Cell Sci · December 1999 Featured Publication SP85 is a multidomain protein of the Dictyostelium spore coat whose C-terminal region binds cellulose in vitro. To map domains critical for localizing SP85 and for binding to other proteins in vivo, its N- and C-terminal regions, and a hybrid fusion of the ... Full text Link to item Cite

Two proteins of the Dictyostelium spore coat bind to cellulose in vitro.

Journal article Biochemistry · July 28, 1998 Featured Publication The spore coat of Dictyostelium contains nine different proteins and cellulose. Interactions between protein and cellulose were investigated using an in vitro binding assay. Proteins extracted from coats with urea and 2-mercaptoethanol could, after removal ... Full text Link to item Cite

SP75 is encoded by the DP87 gene and belongs to a family of modular Dictyostelium discoideum outer layer spore coat proteins.

Journal article Microbiology (Reading) · August 1996 Featured Publication Highly purified spore coats of Dictyostelium discoideum each contained about 5 x 10(6) protein molecules as determined by amino acid composition analysis. By two-dimensional gel electrophoresis the coats were found to contain nine major-abundance and numer ... Full text Link to item Cite