Jesse David Troy | Scholars@Duke

Jesse David Troy
Assistant Professor of Pediatrics

I am a medical statistician who provides statistical support for research studies in stem cell transplantation and cell therapies for a variety of indications including cerebral palsy (CP), brain injury, autism, cancer, and stroke. My personal research interests are related to medical decision making and patient-centered outcomes in hematologic malignancies. I currently serve as the Scientific Director of the Data Coordinating Center for the National MDS Study (http://www.thenationalmdsstudy.net). I also developed and currently teach a course in introductory biostatistics that is required for graduation from the Duke MD degree program, and a course in research study design required for the Master's degree in Biostatistics. Before coming to Duke I worked as a Project Manager/Biostatistician at a large data coordinating center that supported an NIH-funded extramural research programs, including vaccine development and blood and marrow transplantation. I received my PhD in cancer epidemiology from the University of Pittsburgh in 2012 where I was funded by a National Cancer Institute R25 training grant. Prior to completing my PhD I received an MPH from George Washington University. I spent the early part of my career working as a software engineer for Booz Allen Hamilton, AmericaOnline (AOL), and others. I have dedicated my career to learning from data for the purpose of serving patients and their families and continually seek collaboration with other researchers who share my passion and interest in exploring innovative ways to analyze data from medical research studies.

Current Appointments & Affiliations

Assistant Professor of Pediatrics, Pediatrics, Blood and Marrow Transplantation, Pediatrics 2014

Contact Information

2400 Pratt St, Box 3850, Durham, NC 27705
3850, Durham, NC 27705
jesse.troy@duke.edu (919) 668-2932

Background
Education, Training, & Certifications
- Ph.D., University of Pittsburgh 2012
Expertise
Subject Headings
Research
Selected Grants
- High Fidelity Diffusion MRI for Children with Cerebral Palsy in Stem Cell Therapy awarded by National Institutes of Health 2012 - 2022
- High Fidelity Diffusion MRI for Children with Cerebral Palsy in Stem Cell Therapy awarded by National Institutes of Health 2012 - 2022
- EMMES Sub Contract 2015
Industry Relationships
- Aegis-CN
- Cohortias, International
- Gamida-Cell, Ltd.
- Rx Statistics
- The Community Data Roundtable
- The EMMES Corporation
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Troy, Jesse D., Susan C. Locke, Greg P. Samsa, Joseph Feliciano, Akshara Richhariya, and Thomas W. LeBlanc. “Patient-reported distress in Hodgkin lymphoma across the survivorship continuum..” Support Care Cancer 27, no. 7 (July 2019): 2453–62. https://doi.org/10.1007/s00520-018-4523-4.
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  - Kamal, Arif H., Steven P. Wolf, Jesse Troy, Victoria Leff, Constance Dahlin, Joseph D. Rotella, George Handzo, Phillip E. Rodgers, and Evan R. Myers. “Policy Changes Key To Promoting Sustainability And Growth Of The Specialty Palliative Care Workforce..” Health Aff (Millwood) 38, no. 6 (June 2019): 910–18. https://doi.org/10.1377/hlthaff.2019.00018.
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  - Sekeres, Mikkael A., Steven D. Gore, Donald M. Stablein, Nancy DiFronzo, Gregory A. Abel, Amy E. DeZern, Jesse D. Troy, et al. “The National MDS Natural History Study: design of an integrated data and sample biorepository to promote research studies in myelodysplastic syndromes..” Leuk Lymphoma, May 21, 2019, 1–11. https://doi.org/10.1080/10428194.2019.1616186.
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  - Allewelt, Heather, Mahsa Taskindoust, Jesse Troy, Kristin Page, Susan Wood, Suhag Parikh, Vinod K. Prasad, and Joanne Kurtzberg. “Long-Term Functional Outcomes after Hematopoietic Stem Cell Transplant for Early Infantile Krabbe Disease..” Biol Blood Marrow Transplant 24, no. 11 (November 2018): 2233–38. https://doi.org/10.1016/j.bbmt.2018.06.020.
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  - Laskowitz, Daniel T., Ellen R. Bennett, Rebecca J. Durham, John J. Volpi, Jonathan R. Wiese, Michael Frankel, Elizabeth Shpall, Jeffry M. Wilson, Jesse Troy, and Joanne Kurtzberg. “Allogeneic Umbilical Cord Blood Infusion for Adults with Ischemic Stroke: Clinical Outcomes from a Phase I Safety Study..” Stem Cells Transl Med 7, no. 7 (July 2018): 521–29. https://doi.org/10.1002/sctm.18-0008.
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  - Han, Peng, Hongliang Liu, Qiong Shi, Zhensheng Liu, Jesse D. Troy, Walter T. Lee, Jose P. Zevallos, Guojun Li, Erich M. Sturgis, and Qingyi Wei. “Associations between expression levels of nucleotide excision repair proteins in lymphoblastoid cells and risk of squamous cell carcinoma of the head and neck..” Mol Carcinog 57, no. 6 (June 2018): 784–93. https://doi.org/10.1002/mc.22801.
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  - Troy, Jesse D., Carlos M. de Castro, Mary Ruth Pupa, Greg P. Samsa, Amy P. Abernethy, and Thomas W. LeBlanc. “Patient-Reported Distress in Myelodysplastic Syndromes and Its Association With Clinical Outcomes: A Retrospective Cohort Study..” J Natl Compr Canc Netw 16, no. 3 (March 2018): 267–73. https://doi.org/10.6004/jnccn.2017.7048.
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  - Sun, Jessica M., Allen W. Song, Laura E. Case, Mohamad A. Mikati, Kathryn E. Gustafson, Ryan Simmons, Ricki Goldstein, et al. “Effect of Autologous Cord Blood Infusion on Motor Function and Brain Connectivity in Young Children with Cerebral Palsy: A Randomized, Placebo-Controlled Trial..” Stem Cells Transl Med 6, no. 12 (December 2017): 2071–78. https://doi.org/10.1002/sctm.17-0102.
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  - Patel, Sachit A., Heather A. Allewelt, Jesse D. Troy, Paul L. Martin, Timothy A. Driscoll, Vinod K. Prasad, Joanne Kurtzberg, Kristin M. Page, and Suhag H. Parikh. “Durable Chimerism and Long-Term Survival after Unrelated Umbilical Cord Blood Transplantation for Pediatric Hemophagocytic Lymphohistiocytosis: A Single-Center Experience..” Biol Blood Marrow Transplant 23, no. 10 (October 2017): 1722–28. https://doi.org/10.1016/j.bbmt.2017.06.013.
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  - Page, Kristin M., Myriam Labopin, Annalisa Ruggeri, Gerard Michel, Cristina Diaz de Heredia, Tracey O’Brien, Alessandra Picardi, et al. “Factors Associated with Long-Term Risk of Relapse after Unrelated Cord Blood Transplantation in Children with Acute Lymphoblastic Leukemia in Remission..” Biol Blood Marrow Transplant 23, no. 8 (August 2017): 1350–58. https://doi.org/10.1016/j.bbmt.2017.04.015.
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  - Dawson, Geraldine, Jessica M. Sun, Katherine S. Davlantis, Michael Murias, Lauren Franz, Jesse Troy, Ryan Simmons, Maura Sabatos-DeVito, Rebecca Durham, and Joanne Kurtzberg. “Autologous Cord Blood Infusions Are Safe and Feasible in Young Children with Autism Spectrum Disorder: Results of a Single-Center Phase I Open-Label Trial..” Stem Cells Transl Med 6, no. 5 (May 2017): 1332–39. https://doi.org/10.1002/sctm.16-0474.
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  - Han, Peng, Fengqin Gao, Hongliang Liu, Zhensheng Liu, Qiong Shi, Jesse D. Troy, Kouros Owzar, et al. “Reduced mRNA expression of nucleotide excision repair genes in lymphocytes and risk of squamous cell carcinoma of the head and neck..” Carcinogenesis 38, no. 5 (May 1, 2017): 504–10. https://doi.org/10.1093/carcin/bgx028.
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  - Saha, Arjun, Susan Buntz, Paula Scotland, Li Xu, Pamela Noeldner, Sachit Patel, Amy Wollish, et al. “A cord blood monocyte-derived cell therapy product accelerates brain remyelination..” Jci Insight 1, no. 13 (August 18, 2016). https://doi.org/10.1172/jci.insight.86667.
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  - Shoulars, Kevin, Pamela Noldner, Jesse D. Troy, Lynn Cheatham, Amanda Parrish, Kristin Page, Tracy Gentry, Andrew E. Balber, and Joanne Kurtzberg. “Development and validation of a rapid, aldehyde dehydrogenase bright-based cord blood potency assay..” Blood 127, no. 19 (May 12, 2016): 2346–54. https://doi.org/10.1182/blood-2015-08-666990.
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  - Troy, Jesse D., Heather R. Hill, Marian G. Ewell, and Sharon E. Frey. “Sex difference in immune response to vaccination: A participant-level meta-analysis of randomized trials of IMVAMUNE smallpox vaccine..” Vaccine 33, no. 41 (October 5, 2015): 5425–31. https://doi.org/10.1016/j.vaccine.2015.08.032.
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  - Troy, Jesse D., Ehab Atallah, Julia T. Geyer, and Wael Saber. “Myelodysplastic syndromes in the United States: an update for clinicians..” Ann Med 46, no. 5 (August 2014): 283–89. https://doi.org/10.3109/07853890.2014.898863.
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  - Atallah, Ehab, Kathryn Bylow, Jesse Troy, and Wael Saber. “Treatment of older patients with high-risk myelodysplastic syndromes (MDS): the emerging role of allogeneic hematopoietic stem cell transplantation (Allo HSCT)..” Curr Hematol Malig Rep 9, no. 1 (March 2014): 57–65. https://doi.org/10.1007/s11899-013-0195-9.
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  - Troy, Jesse D., Joel L. Weissfeld, Ada O. Youk, Sufi Thomas, Lin Wang, and Jennifer R. Grandis. “Expression of EGFR, VEGF, and NOTCH1 suggest differences in tumor angiogenesis in HPV-positive and HPV-negative head and neck squamous cell carcinoma..” Head Neck Pathol 7, no. 4 (December 2013): 344–55. https://doi.org/10.1007/s12105-013-0447-y.
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  - Troy, Jesse D., Jennifer R. Grandis, Ada O. Youk, Brenda Diergaarde, Marjorie Romkes, and Joel L. Weissfeld. “Childhood passive smoke exposure is associated with adult head and neck cancer..” Cancer Epidemiol 37, no. 4 (August 2013): 417–23. https://doi.org/10.1016/j.canep.2013.03.011.
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  - Troy, Jesse D., Joel L. Weissfeld, Brenda Diergaarde, Ada O. Youk, Shama C. Buch, Marjorie Romkes, and Jennifer R. Grandis. “Polymorphisms in NAT2 and GSTP1 are associated with survival in oral and oropharyngeal cancer..” Cancer Epidemiol 37, no. 4 (August 2013): 505–11. https://doi.org/10.1016/j.canep.2013.02.009.
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  - Troy, Jesse D., Patricia Hartge, Joel L. Weissfeld, Martin M. Oken, Graham A. Colditz, Leah E. Mechanic, and Lindsay M. Morton. “Associations between anthropometry, cigarette smoking, alcohol consumption, and non-Hodgkin lymphoma in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial..” Am J Epidemiol 171, no. 12 (June 15, 2010): 1270–81. https://doi.org/10.1093/aje/kwq085.
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- Conference Papers
  - Muñiz Alers, Saisha M., Kristin Page, Ryan Simmons, Barbara Waters-Pick, Lynn Cheatham, Jesse D. Troy, and Joanne Kurtzberg. “Automated thawing increases recovery of colony-forming units from banked cord blood unit grafts..” In Transfusion, 58:2911–17, 2018. https://doi.org/10.1111/trf.14938.
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  - Vallely, Jaxon, Jesse D. Troy, Susan C. Locke, and Thomas William LeBlanc. “Psychological distress in myelodysplastic syndromes..” In Journal of Clinical Oncology, 36:e19027–e19027. American Society of Clinical Oncology (ASCO), 2018. https://doi.org/10.1200/jco.2018.36.15_suppl.e19027.
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  - Troy, Jesse D., Susan C. Locke, Mary Ruth Pupa, Joseph Feliciano, Akshara Richhariya, and Thomas W. LeBlanc. “Patient-Reported Distress in Hodgkin Lymphoma Patients on Active Therapy Vs. Long-Term Survivors.” In Blood, Vol. 130. AMER SOC HEMATOLOGY, 2017.
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  - Troy, Jesse D., Carlos deCastro, Mary Ruth Pupa, Greg P. Samsa, Amy Pickar Abernethy, and Thomas William LeBlanc. “Patient-reported distress in myelodysplastic syndromes and its relationship with clinical outcomes..” In Journal of Clinical Oncology, 35:e21564–e21564. American Society of Clinical Oncology (ASCO), 2017. https://doi.org/10.1200/jco.2017.35.15_suppl.e21564.
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  - Kurtzberg, Joanne, Jesse D. Troy, Ellen Bennett, Samir Belagaje, Elizabeth J. Shpall, Jonathan Wiese, John Volpi, and Daniel Laskowitz. “Allogeneic Umbilical Cord Blood Infusion for Adults with Ischemic Stroke (CoBIS): Clinical Outcomes from a Phase 1 Safety Study.” In Blood, Vol. 128. AMER SOC HEMATOLOGY, 2016.
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  - Troy, Jesse D., Carlos deCastro, Mary Ruth Pupa, Greg P. Samsa, Amy Pickar Abernethy, and Thomas William LeBlanc. “Patient-reported distress in adults with myelodysplastic syndromes (MDS)..” In Journal of Clinical Oncology, 34:80–80. American Society of Clinical Oncology (ASCO), 2016. https://doi.org/10.1200/jco.2016.34.26_suppl.80.
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  - Allewelt, Heather, Mahsa Taskindoust, Jesse Troy, Kristin Page, Susan Wood, Suhag Parikh, Vinod Prasad, and Joanne Kurtzberg. “Long-Term Functional Outcomes Following Hematopoietic Stem Cell Transplantation for Early Infantile Krabbe Disease.” In Transfusion, 56:7A-8A. WILEY-BLACKWELL, 2016.
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  - Allewelt, Heather B., Kristin Page, Mahsa Taskindoust, Jesse D. Troy, Susan Wood, Suhag Parikh, Vinod K. Prasad, and Joanne Kurtzberg. “Long-Term Functional Outcomes following Hematopoietic Stem Cell Transplantation for Krabbe Disease.” In Biology of Blood and Marrow Transplantation, 22:S102–3. Elsevier BV, 2016. https://doi.org/10.1016/j.bbmt.2015.11.405.
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  - Page, Kristin, Jose Hernandez, Jesse D. Troy, Ana Valverde Vidal, and Joanne Kurtzberg. “Targeting Cord Blood Units with Higher Total Nucleated Cell Count for Inclusion in a Public Cord Blood Bank: Impact on Inventory Diversity and Self-Sustainability.” In Biology of Blood and Marrow Transplantation, 22:S81–S81. Elsevier BV, 2016. https://doi.org/10.1016/j.bbmt.2015.11.375.
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  - Sun, Jessica, Mohamad Mikati, Jesse D. Troy, Kathryn Gustafson, Ryan Simmons, Ricki Goldstein, Jodi Petry, et al. “Adequately Dosed Autologous Cord Blood Infusion Is Associated with Motor Improvement in Children with Cerebral Palsy.” In Biology of Blood and Marrow Transplantation, 22:S61–62. Elsevier BV, 2016. https://doi.org/10.1016/j.bbmt.2015.11.354.
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  - Sun, Jessica, Jennifer Gilner, Jesse Troy, Barbara Waters-Pick, Kristin Page, Amy Murtha, and Joanne Kurtzberg. “530: Preterm umbilical cord blood is enriched for progenitor cells.” In American Journal of Obstetrics and Gynecology, 214:S286–87. Elsevier BV, 2016. https://doi.org/10.1016/j.ajog.2015.10.574.
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  - Sun, Jessica, Mohamad Mikati, Jesse Troy, Kathryn Gustafson, Ryan Simmons, Ricki Goldstein, Jodi Petry, et al. “Autologous Cord Blood Infusion for the Treatment of Brain Injury in Children with Cerebral Palsy.” In Blood, Vol. 126. AMER SOC HEMATOLOGY, 2015.
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  - Shoulars, Kevin, Jesse D. Troy, Tracy Gentry, Pamela Noldner, Kristin Page, Andrew Balber, and Joanne Kurtzberg. “Aldehyde dehydrogenase, but not viability of CD34 cells, predicts potency and engraftment after cord blood transplantation.” In Cytotherapy, 17:S14–S14. Elsevier BV, 2015. https://doi.org/10.1016/j.jcyt.2015.03.330.
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  - Shoulars, K., J. D. Troy, T. Gentry, P. Noldner, K. Page, A. Balber, and J. Kurtzberg. “Experience in a public cord blood bank using a segment-based aldehyde dehydrogenase assay as a biomarker for umbilical cord blood potency.” In Cytotherapy, 16:S59–S59. Elsevier BV, 2014. https://doi.org/10.1016/j.jcyt.2014.01.213.
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  - Shoulars, Kevin, Jesse D. Troy, Pamela Noldner, Tracy Gentry, Kristin Page, Robert Storms, Andrew E. Balber, and Joanne Kurtzberg. “Experience in a Public Cord Blood Bank Using a Segment-Based Aldehyde Dehydrogenase Assay As a Biomarker for Umbilical Cord Blood Potency.” In Biology of Blood and Marrow Transplantation, 20:S187–88. Elsevier BV, 2014. https://doi.org/10.1016/j.bbmt.2013.12.307.
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Teaching & Mentoring
Recent Courses
Advising & Mentoring
- Student:       Julia Messina, MD
  Project Title: Genomic Characterization of Enterococcal Bloodstream Isolates in Hematologic Malignancies
  My Role:       Master's thesis committee member, CRTP program
  
  Student:       Saisha Muniz Alerz, MD
  Project Title: Comparison of Automated and Manual Washing of Umbilical Cord Blood for Hematopoietic Stem Cell
                      Transplantation
  My Role:       Scholarship Oversight Committee (SOC) member, Hematology/Oncology Fellowship Program

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Education, Training, & Certifications

Subject Headings

Selected Grants

Industry Relationships

Selected Publications

Academic Articles

Conference Papers

Recent Courses

Advising & Mentoring