Jessica Sawyer
Assistant Research Professor of Pharmacology and Cancer Biology
Dr. Sawyer studies organ boundary communication and non-stem-cell mechanisms of repair in the Fox Lab.
Dr. Sawyer is also dedicated to teaching and mentorship.
Dr. Sawyer is also dedicated to teaching and mentorship.
Current Appointments & Affiliations
- Assistant Research Professor of Pharmacology and Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2018
Contact Information
- 308 Research Drive, DUMC 3813, LSRC B234, Durham, NC 27710
- DUMC 3813, LSRC B234, Durham, NC 27710
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jessica.sawyer@duke.edu
(919) 660-7355
- Background
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Education, Training, & Certifications
- Ph.D., University of North Carolina - Chapel Hill 2010
- Expertise
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Subject Headings
- Research
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Selected Grants
- Polyploidy after tissue injury: a Drosophila model awarded by National Institutes of Health 2016 - 2025
- Institutional Summer Undergraduate Research Fellowship (SURF) awarded by American Society for Pharmacology and Experimental Therapeutics 2018 - 2025
- Examining infection-mediated metastasis with single-cell resolution awarded by National Institutes of Health 2014 - 2016
- Publications & Artistic Works
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Selected Publications
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Books
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Harris, Tony J. C., Jessica K. Sawyer, and Mark Peifer. How the cytoskeleton helps build the embryonic body plan: models of morphogenesis from Drosophila. Vol. 89, 2009. https://doi.org/10.1016/S0070-2153(09)89003-0.Full Text Link to Item
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Academic Articles
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Allen, Scott R., Rebeccah K. Stewart, Michael Rogers, Ivan Jimenez Ruiz, Erez Cohen, Alain Laederach, Christopher M. Counter, Jessica K. Sawyer, and Donald T. Fox. “Distinct responses to rare codons in select Drosophila tissues.” Elife 11 (May 6, 2022). https://doi.org/10.7554/eLife.76893.Full Text Link to Item
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Cohen, Erez, Nora G. Peterson, Jessica K. Sawyer, and Donald T. Fox. “Accelerated cell cycles enable organ regeneration under developmental time constraints in the Drosophila hindgut.” Dev Cell 56, no. 14 (July 26, 2021): 2059-2072.e3. https://doi.org/10.1016/j.devcel.2021.04.029.Full Text Link to Item
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Sawyer, Jessica K., Zahra Kabiri, Ruth A. Montague, Scott R. Allen, Rebeccah Stewart, Sarah V. Paramore, Erez Cohen, Hamed Zaribafzadeh, Christopher M. Counter, and Donald T. Fox. “Exploiting codon usage identifies intensity-specific modifiers of Ras/MAPK signaling in vivo.” Plos Genet 16, no. 12 (December 2020): e1009228. https://doi.org/10.1371/journal.pgen.1009228.Full Text Link to Item
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Cohen, Erez, Jessica K. Sawyer, Nora G. Peterson, Julian A. T. Dow, and Donald T. Fox. “Physiology, Development, and Disease Modeling in the Drosophila Excretory System.” Genetics 214, no. 2 (February 2020): 235–64. https://doi.org/10.1534/genetics.119.302289.Full Text Link to Item
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Cohen, Erez, Scott R. Allen, Jessica K. Sawyer, and Donald T. Fox. “Fizzy-Related dictates A cell cycle switch during organ repair and tissue growth responses in the Drosophila hindgut.” Elife 7 (August 17, 2018). https://doi.org/10.7554/eLife.38327.Full Text Link to Item
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Cohen, Erez, Scott Allen, Jessica Sawyer, and Donald Fox. “A Cell Cycle Switch Dictates Organ Repair and Tissue Growth Responses in TheDrosophilaHindgut,” 2018. https://doi.org/10.1101/331223.Full Text
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Sawyer, Jessica K., Erez Cohen, and Donald T. Fox. “Interorgan regulation of Drosophila intestinal stem cell proliferation by a hybrid organ boundary zone.” Development 144, no. 22 (November 15, 2017): 4091–4102. https://doi.org/10.1242/dev.153114.Full Text Link to Item
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Sawyer, Jessica, Erez Cohen, and Donald Fox. “Inter-organ regulation ofDrosophilaintestinal stem cell proliferation by a hybrid organ boundary zone,” 2017. https://doi.org/10.1101/152074.Full Text
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Cai, Danfeng, Shann-Ching Chen, Mohit Prasad, Li He, Xiaobo Wang, Valerie Choesmel-Cadamuro, Jessica K. Sawyer, Gaudenz Danuser, and Denise J. Montell. “Mechanical feedback through E-cadherin promotes direction sensing during collective cell migration.” Cell 157, no. 5 (May 22, 2014): 1146–59. https://doi.org/10.1016/j.cell.2014.03.045.Full Text Link to Item
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Sawyer, Jessica K., Wangsun Choi, Kuo-Chen Jung, Li He, Nathan J. Harris, and Mark Peifer. “A contractile actomyosin network linked to adherens junctions by Canoe/afadin helps drive convergent extension.” Mol Biol Cell 22, no. 14 (July 15, 2011): 2491–2508. https://doi.org/10.1091/mbc.E11-05-0411.Full Text Link to Item
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Sawyer, Jessica K., Nathan J. Harris, and Mark Peifer. “Morphogenesis: multitalented GTPases seeking new jobs.” Curr Biol 19, no. 21 (November 17, 2009): R985–87. https://doi.org/10.1016/j.cub.2009.09.060.Full Text Link to Item
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Roeth, Jeremiah F., Jessica K. Sawyer, Daniel A. Wilner, and Mark Peifer. “Rab11 helps maintain apical crumbs and adherens junctions in the Drosophila embryonic ectoderm.” Plos One 4, no. 10 (October 28, 2009): e7634. https://doi.org/10.1371/journal.pone.0007634.Full Text Link to Item
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Sawyer, Jessica K., Nathan J. Harris, Kevin C. Slep, Ulrike Gaul, and Mark Peifer. “The Drosophila afadin homologue Canoe regulates linkage of the actin cytoskeleton to adherens junctions during apical constriction.” J Cell Biol 186, no. 1 (July 13, 2009): 57–73. https://doi.org/10.1083/jcb.200904001.Full Text Link to Item
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Datasets
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Montell, Denise, and Jessica Sawyer. “Faculty Opinions recommendation of A mechanoresponsive cadherin-keratin complex directs polarized protrusive behavior and collective cell migration.,” April 18, 2012. https://doi.org/10.3410/f.13411042.15778104.Data Access
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Montell, Denise, and Jessica Sawyer. “Faculty Opinions recommendation of Lulu2 regulates the circumferential actomyosin tensile system in epithelial cells through p114RhoGEF.,” November 23, 2011. https://doi.org/10.3410/f.13372957.14743055.Data Access
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- Teaching & Mentoring
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Recent Courses
- BIOLOGY 314: Regenerative Biology and Medicine 2023
- I&E 835: Innovations in Drug Development 2023
- MOLCAN 819: Cancer as a Disease 2023
- NEUROSCI 350: Pharmacology: Drug Actions and Reactions 2023
- PHARM 350: Pharmacology: Drug Actions and Reactions 2023
- PHARM 494: Research Independent Study 2023
- PHARM 835: Innovations in Drug Development 2023
- I&E 835: Innovations in Drug Development 2022
- MOLCAN 819: Cancer as a Disease 2022
- NEUROSCI 350: Pharmacology: Drug Actions and Reactions 2022
- PHARM 294: Research Independent Study in Science Education 2022
- PHARM 350: Pharmacology: Drug Actions and Reactions 2022
- PHARM 394: Research Independent Study 2022
- PHARM 493: Research Independent Study 2022
- PHARM 835: Innovations in Drug Development 2022
- I&E 835: Innovations in Drug Development 2021
- NEUROSCI 350: Pharmacology: Drug Actions and Reactions 2021
- PHARM 293: Research Independent Study in Science Education 2021
- PHARM 294: Research Independent Study in Science Education 2021
- PHARM 350: Pharmacology: Drug Actions and Reactions 2021
- PHARM 393: Research Independent Study 2021
- PHARM 493: Research Independent Study 2021
- PHARM 835: Innovations in Drug Development 2021
- Scholarly, Clinical, & Service Activities
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Service to the Profession
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