Jiaoti Huang | Scholars@Duke

Jiaoti Huang
Endowed Department Chair of Pathology

I am a physician-scientist with clinical expertise in the pathologic diagnosis of genitourinary tumors including tumors of the prostate, bladder, kidney and testis. Another area of interest is gynecologic tumors. In my research laboratory we study prostate cancer, focusing on molecular mechanisms of carcinogenesis and tumor progression, as well as biomarkers, imaging and novel therapeutic strategies. In addition to patient care and research, I am also passionate about education. I have trained numerous residents, fellows, graduate students and postdocs.

Current Appointments & Affiliations

Endowed Department Chair of Pathology, Pathology, Clinical Science Departments 2017
Professor of Pathology, Pathology, Clinical Science Departments 2016
Chair, Pathology, Clinical Science Departments 2016
Professor of Pharmacology and Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2017
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2016

Contact Information

Background
Education, Training, & Certifications
- Ph.D., New York University 1991
- M.D., Anhui Medical University (China) 1983
Duke Appointment History
- Instructor, Temporary in the Department of Pathology, Pathology, Clinical Science Departments 2015
Research
Selected Grants
- Duke CTSA (KL2) awarded by National Institutes of Health 2018 - 2023
- Duke CTSA (TL1) awarded by National Institutes of Health 2018 - 2023
- Role of oncogenic phosphorylated MED1 in aggressive prostate cancer awarded by National Institutes of Health 2017 - 2022
- Targeting the p38/Snail/PD-L1 axis in hormone-therapy resistance and metastasis awarded by Department of Defense 2018 - 2021
- Histologic and Immunohistochemical Biomarkers for Heavily Treated Metastatic Prostate Cancer awarded by National Institutes of Health 2016 - 2021
- Novel Tumor Suppressive Role of Phosphodiesterases in Prostate Cancer awarded by Department of Defense 2016 - 2019
- Role and targeting of PRMT5 in prostate cancer awarded by Purdue University 2017 - 2019
- Systems Analysis of Epigenomic Architecture in Cancer Progression (Project 2: Fine-scale nucleosome repositioning of enhancers for hormone-independent genomic function) awarded by University of Texas Health Science Center at San Antonio 2017 - 2019
- Heparan sulfate in prostate cancer awarded by University of Georgia 2018 - 2019
- Genetic screen of calorie restricted and western diet essential kinases in prostate cancer awarded by Prostate Cancer Foundation 2018 - 2019
- Identification of DNA methylation markers for risk of metastasis in localized prostate cancer awarded by Kaiser Permanente 2016 - 2018
- Role of the Stroma in Fibrolamellar Hepatocellular Carcinoma awarded by Fibrolamellar Cancer Foundation 2016 - 2018
- Paired Acquisition In Refractory Prostate Cancer (PAIR): Advancing the Promise of the PCF/SU2C/AACR West Coast Prostate Cancer Dream Team awarded by University of California - San Francisco 2016 - 2018
- A novel strategy to identify prostate cancer biomarkers for patient management awarded by National Institutes of Health 2013 - 2018
- Systems Analysis of Epigenomic Architecture in Cancer Progression awarded by University of Texas Health Science Center at San Antonio 2017 - 2018
- : Identification of DNA methylation markers for risk of metastasis in localized prostate cancer awarded by Kaiser Permanente 2016
- Stand Up 2 Cancer West Coast Dream Team Grant awarded by University of San Francisco 2013 - 2016
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Koo, M, Squires, JM, Ying, D, and Huang, J. "Making a Tissue Microarray." Methods in Molecular Biology (Clifton, N.J.) 1897 (January 2019): 313-323. Full Text
  - Xu, L, Ma, E, Zeng, T, Zhao, R, Tao, Y, Chen, X, Groth, J, Liang, C, Hu, H, and Huang, J. "ATM deficiency promotes progression of CRPC by enhancing Warburg effect." Endocrine Related Cancer 26, no. 1 (January 2019): 59-71. Full Text
  - Aggarwal, R, Huang, J, Alumkal, J, Feng, FY, Zhang, L, Stuart, JM, and Small, EJ. "Reply to A. Dalla Volta et al." Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology (December 17, 2018): JCO1801487-null. Full Text
  - Aminsharifi, A, Gupta, RT, Huang, J, and Polascik, TJ. "Three-dimensional localization and targeting of prostate cancer foci with imaging and histopathologic correlation: establishing a multidisciplinary team for quality improvement." Current Opinion in Urology 28, no. 6 (November 2018): 506-511. Full Text
  - Park, JW, Lee, JK, Sheu, KM, Wang, L, Balanis, NG, Nguyen, K, Smith, BA, Cheng, C, Tsai, BL, Cheng, D, Huang, J, Kurdistani, SK, Graeber, TG, and Witte, ON. "Reprogramming normal human epithelial tissues to a common, lethal neuroendocrine cancer lineage." Science (New York, N.Y.) 362, no. 6410 (October 2018): 91-95. Full Text
  - Li, Q, Deng, Q, Chao, H-P, Liu, X, Lu, Y, Lin, K, Liu, B, Tang, GW, Zhang, D, Tracz, A, Jeter, C, Rycaj, K, Calhoun-Davis, T, Huang, J, Rubin, MA, Beltran, H, Shen, J, Chatta, G, Puzanov, I, Mohler, JL, Wang, J, Zhao, R, Kirk, J, Chen, X, and Tang, DG. "Linking prostate cancer cell AR heterogeneity to distinct castration and enzalutamide responses." Nature Communications 9, no. 1 (September 6, 2018): 3600-null. Full Text
  - Nagarajan, MB, Raman, SS, Lo, P, Lin, W-C, Khoshnoodi, P, Sayre, JW, Ramakrishna, B, Ahuja, P, Huang, J, Margolis, DJA, Lu, DSK, Reiter, RE, Goldin, JG, Brown, MS, and Enzmann, DR. "Building a high-resolution T2-weighted MR-based probabilistic model of tumor occurrence in the prostate." Abdominal Radiology (New York) 43, no. 9 (September 2018): 2487-2496. Full Text
  - Smith, BA, Balanis, NG, Nanjundiah, A, Sheu, KM, Tsai, BL, Zhang, Q, Park, JW, Thompson, M, Huang, J, Witte, ON, and Graeber, TG. "A Human Adult Stem Cell Signature Marks Aggressive Variants across Epithelial Cancers." Cell Reports 24, no. 12 (September 2018): 3353-3366.e5. Full Text
  - Li, Y, Zhang, Q, Lovnicki, J, Chen, R, Fazli, L, Wang, Y, Gleave, M, Huang, J, and Dong, X. "SRRM4 gene expression correlates with neuroendocrine prostate cancer." The Prostate (August 28, 2018). Full Text
  - Lei, K, Sun, R, Chen, LH, Diplas, BH, Moure, CJ, Wang, W, Hansen, LJ, Tao, Y, Chen, X, Chen, C-PJ, Greer, PK, Zhao, F, Yan, H, Bigner, DD, Huang, J, and He, Y. "Mutant allele quantification reveals a genetic basis for TP53 mutation-driven castration resistance in prostate cancer cells." Scientific Reports 8, no. 1 (August 21, 2018): 12507-null. Full Text
  - Aggarwal, R, Huang, J, Alumkal, JJ, Zhang, L, Feng, FY, Thomas, GV, Weinstein, AS, Friedl, V, Zhang, C, Witte, ON, Lloyd, P, Gleave, M, Evans, CP, Youngren, J, Beer, TM, Rettig, M, Wong, CK, True, L, Foye, A, Playdle, D, Ryan, CJ, Lara, P, Chi, KN, Uzunangelov, V, Sokolov, A, Newton, Y, Beltran, H, Demichelis, F, Rubin, MA, Stuart, JM, and Small, EJ. "Clinical and Genomic Characterization of Treatment-Emergent Small-Cell Neuroendocrine Prostate Cancer: A Multi-institutional Prospective Study." Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology 36, no. 24 (August 2018): 2492-2503. Full Text
  - Duvnjak, P, Schulman, AA, Holtz, JN, Huang, J, Polascik, TJ, and Gupta, RT. "Multiparametric Prostate MR Imaging: Impact on Clinical Staging and Decision Making." The Urologic Clinics of North America 45, no. 3 (August 2018): 455-466. (Review) Full Text
  - Quigley, DA, Dang, HX, Zhao, SG, Lloyd, P, Aggarwal, R, Alumkal, JJ, Foye, A, Kothari, V, Perry, MD, Bailey, AM, Playdle, D, Barnard, TJ, Zhang, L, Zhang, J, Youngren, JF, Cieslik, MP, Parolia, A, Beer, TM, Thomas, G, Chi, KN, Gleave, M, Lack, NA, Zoubeidi, A, Reiter, RE, Rettig, MB, Witte, O, Ryan, CJ, Fong, L, Kim, W, Friedlander, T, Chou, J, Li, H, Das, R, Li, H, Moussavi-Baygi, R, Goodarzi, H, Gilbert, LA, Lara, PN, Evans, CP, Goldstein, TC, Stuart, JM, Tomlins, SA, Spratt, DE, Cheetham, RK, Cheng, DT, Farh, K, Gehring, JS, Hakenberg, J, Liao, A, Febbo, PG, Shon, J, Sickler, B, Batzoglou, S, Knudsen, KE, He, HH, Huang, J, Wyatt, AW, Dehm, SM, Ashworth, A, Chinnaiyan, AM, Maher, CA, Small, EJ, and Feng, FY. "Genomic Hallmarks and Structural Variation in Metastatic Prostate Cancer." Cell 174, no. 3 (July 19, 2018): 758-769.e9. Full Text
  - Chen, Z, Wu, D, Thomas-Ahner, JM, Lu, C, Zhao, P, Zhang, Q, Geraghty, C, Yan, PS, Hankey, W, Sunkel, B, Cheng, X, Antonarakis, ES, Wang, Q-E, Liu, Z, Huang, TH-M, Jin, VX, Clinton, SK, Luo, J, Huang, J, and Wang, Q. "Diverse AR-V7 cistromes in castration-resistant prostate cancer are governed by HoxB13." Proceedings of the National Academy of Sciences of the United States of America 115, no. 26 (June 2018): 6810-6815. Full Text
  - Gan, Y, Li, Y, Long, Z, Lee, AR, Xie, N, Lovnicki, JM, Tang, Y, Chen, X, Huang, J, and Dong, X. "Roles of Alternative RNA Splicing of the Bif-1 Gene by SRRM4 During the Development of Treatment-induced Neuroendocrine Prostate Cancer." Ebiomedicine 31 (May 16, 2018): 267-275. Full Text
  - Lee, JK, Bangayan, NJ, Chai, T, Smith, BA, Pariva, TE, Yun, S, Vashisht, A, Zhang, Q, Park, JW, Corey, E, Huang, J, Graeber, TG, Wohlschlegel, J, and Witte, ON. "Systemic surfaceome profiling identifies target antigens for immune-based therapy in subtypes of advanced prostate cancer." Proceedings of the National Academy of Sciences of the United States of America 115, no. 19 (May 2018): E4473-E4482. Full Text
  - Okhunov, Z, Yoon, R, Lusch, A, Spradling, K, Suarez, M, Kaler, KS, Patel, R, Hwang, C, Osann, K, Huang, J, Lee, T, and Landman, J. "Evaluation and Comparison of Contemporary Energy-Based Surgical Vessel Sealing Devices." Journal of Endourology 32, no. 4 (April 2018): 329-337. Full Text
  - Duvnjak, P, Schulman, AA, Holtz, JN, Huang, J, Polascik, TJ, and Gupta, RT. "Multiparametric Prostate MR Imaging: Impact on Clinical Staging and Decision Making." Radiologic clinics of North America 56, no. 2 (March 2018): 239-250. (Review) Full Text
  - Holtz, JN, Silverman, RK, Tay, KJ, Browning, JT, Huang, J, Polascik, TJ, and Gupta, RT. "New prostate cancer prognostic grade group (PGG): Can multiparametric MRI (mpMRI) accurately separate patients with low-, intermediate-, and high-grade cancer?." Abdominal radiology (New York) 43, no. 3 (March 2018): 702-712. Full Text
  - Nassiri, N, Chang, E, Lieu, P, Priester, AM, Margolis, DJA, Huang, J, Reiter, RE, Dorey, FJ, Marks, LS, and Natarajan, S. "Focal Therapy Eligibility Determined by Magnetic Resonance Imaging/Ultrasound Fusion Biopsy." The Journal of Urology 199, no. 2 (February 2018): 453-458. Full Text
  - Chang, E, Jones, TA, Natarajan, S, Sharma, D, Simopoulos, D, Margolis, DJ, Huang, J, Dorey, FJ, and Marks, LS. "Value of Tracking Biopsy in Men Undergoing Active Surveillance of Prostate Cancer." The Journal of Urology 199, no. 1 (January 2018): 98-105. Full Text
  - Felker, ER, Raman, SS, Margolis, DJ, Lu, DSK, Shaheen, N, Natarajan, S, Sharma, D, Huang, J, Dorey, F, and Marks, LS. "Risk Stratification Among Men With Prostate Imaging Reporting and Data System version 2 Category 3 Transition Zone Lesions: Is Biopsy Always Necessary?." Ajr. American Journal of Roentgenology 209, no. 6 (December 2017): 1272-1277. Full Text
  - Chen, W-Y, Tsai, Y-C, Siu, MK, Yeh, H-L, Chen, C-L, Yin, JJ, Huang, J, and Liu, Y-N. "Inhibition of the androgen receptor induces a novel tumor promoter, ZBTB46, for prostate cancer metastasis." Oncogene 36, no. 45 (November 2017): 6213-6224. Full Text
  - Alle, N, Tan, N, Huss, J, Huang, J, Pantuck, A, and Raman, SS. "Percutaneous image-guided core biopsy of solid renal masses: analysis of safety, efficacy, pathologic interpretation, and clinical significance." Abdominal radiology (New York) (October 27, 2017). Full Text
  - Aggarwal, R, Behr, SC, Paris, PL, Truillet, C, Parker, MFL, Huynh, LT, Wei, J, Hann, B, Youngren, J, Huang, J, Premasekharan, G, Ranatunga, N, Chang, E, Gao, KT, Ryan, CJ, Small, EJ, and Evans, MJ. "Real-Time Transferrin-Based PET Detects MYC-Positive Prostate Cancer." Molecular Cancer Research : Mcr 15, no. 9 (September 2017): 1221-1229. Full Text
  - Dai, X, Gan, W, Li, X, Wang, S, Zhang, W, Huang, L, Liu, S, Zhong, Q, Guo, J, Zhang, J, Chen, T, Shimizu, K, Beca, F, Blattner, M, Vasudevan, D, Buckley, DL, Qi, J, Buser, L, Liu, P, Inuzuka, H, Beck, AH, Wang, L, Wild, PJ, Garraway, LA, Rubin, MA, Barbieri, CE, Wong, K-K, Muthuswamy, SK, Huang, J, Chen, Y, Bradner, JE, and Wei, W. "Prostate cancer-associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4." Nature Medicine 23, no. 9 (September 2017): 1063-1071. Full Text
  - Park, JW, Lee, JK, Witte, ON, and Huang, J. "FOXA2 is a sensitive and specific marker for small cell neuroendocrine carcinoma of the prostate." Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc 30, no. 9 (September 2017): 1262-1272. Full Text
  - Tay, KJ, Scheltema, MJ, Ahmed, HU, Barret, E, Coleman, JA, Dominguez-Escrig, J, Ghai, S, Huang, J, Jones, JS, Klotz, LH, Robertson, CN, Sanchez-Salas, R, Scionti, S, Sivaraman, A, de la Rosette, J, and Polascik, TJ. "Patient selection for prostate focal therapy in the era of active surveillance: an International Delphi Consensus Project." Prostate Cancer and Prostatic Diseases 20, no. 3 (September 2017): 294-299. Full Text
  - Chen, W-Y, Tsai, Y-C, Yeh, H-L, Suau, F, Jiang, K-C, Shao, A-N, Huang, J, and Liu, Y-N. "Loss of SPDEF and gain of TGFBI activity after androgen deprivation therapy promote EMT and bone metastasis of prostate cancer." Science Signaling 10, no. 492 (August 15, 2017). Full Text
  - Holmes, MG, Foss, E, Joseph, G, Foye, A, Beckett, B, Motamedi, D, Youngren, J, Thomas, GV, Huang, J, Aggarwal, R, Alumkal, JJ, Beer, TM, Small, EJ, and Link, TM. "CT-Guided Bone Biopsies in Metastatic Castration-Resistant Prostate Cancer: Factors Predictive of Maximum Tumor Yield." Journal of Vascular and Interventional Radiology : Jvir 28, no. 8 (August 2017): 1073-1081.e1. Full Text
  - Grant, DJ, Chen, Z, Howard, LE, Wiggins, E, De Hoedt, A, Vidal, AC, Carney, ST, Squires, J, Magyar, CE, Huang, J, and Freedland, SJ. "UDP-glucuronosyltransferases and biochemical recurrence in prostate cancer progression." Bmc Cancer 17, no. 1 (July 3, 2017): 463-null. Full Text
  - Chen, K, Xiao, H, Zeng, J, Yu, G, Zhou, H, Huang, C, Yao, W, Xiao, W, Hu, J, Guan, W, Wu, L, Huang, J, Huang, Q, Xu, H, and Ye, Z. "Alternative Splicing of EZH2 pre-mRNA by SF3B3 Contributes to the Tumorigenic Potential of Renal Cancer." Clinical Cancer Research : an Official Journal of the American Association for Cancer Research 23, no. 13 (July 2017): 3428-3441. Full Text
  - Jamshidi, N, Margolis, DJ, Raman, S, Huang, J, Reiter, RE, and Kuo, MD. "Multiregional Radiogenomic Assessment of Prostate Microenvironments with Multiparametric MR Imaging and DNA Whole-Exome Sequencing of Prostate Glands with Adenocarcinoma." Radiology 284, no. 1 (July 2017): 109-119. Full Text
  - Hegde, JV, Margolis, DJ, Wang, P-C, Reiter, RE, Huang, J, Steinberg, ML, and Kamrava, M. "Establishing the distribution of satellite lesions in intermediate- and high-risk prostate cancer: implications for focused radiotherapy." Prostate cancer and prostatic diseases 20, no. 2 (June 2017): 241-248. Full Text
  - Nassiri, N, Margolis, DJ, Natarajan, S, Sharma, DS, Huang, J, Dorey, FJ, and Marks, LS. "Targeted Biopsy to Detect Gleason Score Upgrading during Active Surveillance for Men with Low versus Intermediate Risk Prostate Cancer." The Journal of Urology 197, no. 3 Pt 1 (March 2017): 632-639. Full Text
  - Palapattu, GS, Salami, SS, Cani, AK, Hovelson, DH, Lazo de la Vega, L, Vandenberg, KR, Bratley, JV, Liu, C-J, Kunju, LP, Montgomery, JS, Morgan, TM, Natarajan, S, Huang, J, Tomlins, SA, and Marks, LS. "Molecular Profiling to Determine Clonality of Serial Magnetic Resonance Imaging/Ultrasound Fusion Biopsies from Men on Active Surveillance for Low-Risk Prostate Cancer." Clinical Cancer Research : an Official Journal of the American Association for Cancer Research 23, no. 4 (February 2017): 985-991. Full Text
  - Priester, A, Natarajan, S, Khoshnoodi, P, Margolis, DJ, Raman, SS, Reiter, RE, Huang, J, Grundfest, W, and Marks, LS. "Magnetic Resonance Imaging Underestimation of Prostate Cancer Geometry: Use of Patient Specific Molds to Correlate Images with Whole Mount Pathology." The Journal of Urology 197, no. 2 (February 2017): 320-326. Full Text
  - Feng, N, Yin, Y, He, Y, and Huang, J. "Alternative Splicing Provides a Novel Molecular Mechanism for Prostatic Small-cell Neuroendocrine Carcinoma." European urology 71, no. 1 (January 2017): 79-80. Full Text
  - Tsai, Y-C, Chen, W-Y, Siu, MK, Tsai, H-Y, Yin, JJ, Huang, J, and Liu, Y-N. "Epidermal growth factor receptor signaling promotes metastatic prostate cancer through microRNA-96-mediated downregulation of the tumor suppressor ETV6." Cancer Letters 384 (January 2017): 1-8. Full Text
  - Yin, Y, Zhang, Q, Zhang, H, He, Y, and Huang, J. "Molecular Signature to Risk-Stratify Prostate Cancer of Intermediate Risk." Clinical Cancer Research : an Official Journal of the American Association for Cancer Research 23, no. 1 (January 2017): 6-8. (Letter) Full Text Open Access Copy
  - Aggarwal, R, Beer, TM, Gleave, M, Stuart, JM, Rettig, M, Evans, CP, Youngren, J, Alumkal, JJ, Huang, J, Thomas, G, Witte, O, and Small, EJ. "Targeting Adaptive Pathways in Metastatic Treatment-Resistant Prostate Cancer: Update on the Stand Up 2 Cancer/Prostate Cancer Foundation-Supported West Coast Prostate Cancer Dream Team." European urology focus 2, no. 5 (December 2016): 469-471. Full Text
  - Wu, M, Ingram, L, Tolosa, EJ, Vera, RE, Li, Q, Kim, S, Ma, Y, Spyropoulos, DD, Beharry, Z, Huang, J, Fernandez-Zapico, ME, and Cai, H. "Gli Transcription Factors Mediate the Oncogenic Transformation of Prostate Basal Cells Induced by a Kras-Androgen Receptor Axis." The Journal of Biological Chemistry 291, no. 49 (December 2016): 25749-25760. Full Text
  - Yan, Y, Li, Z, Xu, X, Chen, C, Wei, W, Fan, M, Chen, X, Li, JJ, Wang, Y, and Huang, J. "All-trans retinoic acids induce differentiation and sensitize a radioresistant breast cancer cells to chemotherapy." Bmc Complementary and Alternative Medicine 16, no. 1 (December 2016). Full Text
  - Stoyanova, T, Riedinger, M, Lin, S, Faltermeier, CM, Smith, BA, Zhang, KX, Going, CC, Goldstein, AS, Lee, JK, Drake, JM, Rice, MA, Hsu, E-C, Nowroozizadeh, B, Castor, B, Orellana, SY, Blum, SM, Cheng, D, Pienta, KJ, Reiter, RE, Pitteri, SJ, Huang, J, and Witte, ON. "Activation of Notch1 synergizes with multiple pathways in promoting castration-resistant prostate cancer." Proceedings of the National Academy of Sciences of the United States of America 113, no. 42 (October 2016): E6457-E6466. Full Text
  - Drake, JM, Paull, EO, Graham, NA, Lee, JK, Smith, BA, Titz, B, Stoyanova, T, Faltermeier, CM, Uzunangelov, V, Carlin, DE, Fleming, DT, Wong, CK, Newton, Y, Sudha, S, Vashisht, AA, Huang, J, Wohlschlegel, JA, Graeber, TG, Witte, ON, and Stuart, JM. "Phosphoproteome Integration Reveals Patient-Specific Networks in Prostate Cancer." Cell 166, no. 4 (August 4, 2016): 1041-1054. Full Text
  - Natarajan, S, Raman, S, Priester, AM, Garritano, J, Margolis, DJA, Lieu, P, Macairan, ML, Huang, J, Grundfest, W, and Marks, LS. "Focal Laser Ablation of Prostate Cancer: Phase I Clinical Trial." The Journal of Urology 196, no. 1 (July 2016): 68-75. Full Text
  - Zhang, H, Prado, K, Zhang, KX, Peek, EM, Lee, J, Wang, X, Huang, J, Li, G, Pellegrini, M, and Chin, AI. "Biased Expression of the FOXP3Δ3 Isoform in Aggressive Bladder Cancer Mediates Differentiation and Cisplatin Chemotherapy Resistance." Clinical Cancer Research (May 17, 2016). Link to Item
  - Felker, ER, Lee-Felker, SA, Feller, J, Margolis, DJ, Lu, DS, Princenthal, R, May, S, Cohen, M, Huang, J, Yoshida, J, Greenwood, B, Kim, HJ, and Raman, SS. "In-bore magnetic resonance-guided transrectal biopsy for the detection of clinically significant prostate cancer." Abdominal Radiology 41, no. 5 (May 2016): 954-962. Full Text
  - Park, JW, Lee, JK, Phillips, JW, Huang, P, Cheng, D, Huang, J, and Witte, ON. "Prostate epithelial cell of origin determines cancer differentiation state in an organoid transformation assay." Proceedings of the National Academy of Sciences of USA 113, no. 16 (April 19, 2016): 4482-4487. Link to Item
  - Park, JW, Lee, JK, Phillips, JW, Huang, P, Cheng, D, Huang, J, and Witte, ON. "Prostate epithelial cell of origin determines cancer differentiation state in an organoid transformation assay." Proceedings of the National Academy of Sciences of the United States of America 113, no. 16 (April 4, 2016): 4482-4487. Full Text
  - Lee, JK, Phillips, JW, Smith, BA, Park, JW, Stoyanova, T, McCaffrey, EF, Baertsch, R, Sokolov, A, Meyerowitz, JG, Mathis, C, Cheng, D, Stuart, JM, Shokat, KM, Gustafson, WC, Huang, J, and Witte, ON. "N-Myc Drives Neuroendocrine Prostate Cancer Initiated from Human Prostate Epithelial Cells." Cancer Cell 29, no. 4 (April 2016): 536-547. Full Text
  - Li, W, Cohen, A, Sun, Y, Squires, J, Braas, D, Graeber, TG, Du, L, Li, G, Li, Z, Xu, X, Chen, X, and Huang, J. "The Role of CD44 in Glucose Metabolism in Prostatic Small Cell Neuroendocrine Carcinoma." Molecular cancer research : MCR 14, no. 4 (April 2016): 344-353. Full Text
  - Filson, CP, Natarajan, S, Margolis, DJA, Huang, J, Lieu, P, Dorey, FJ, Reiter, RE, and Marks, LS. "Prostate cancer detection with magnetic resonance-ultrasound fusion biopsy: The role of systematic and targeted biopsies." Cancer 122, no. 6 (March 15, 2016): 884-892. Full Text
  - Faltermeier, CM, Drake, JM, Clark, PM, Smith, BA, Zong, Y, Volpe, C, Mathis, C, Morrissey, C, Castor, B, Huang, J, and Witte, ON. "Functional screen identifies kinases driving prostate cancer visceral and bone metastasis." Proceedings of the National Academy of Sciences 113, no. 2 (January 12, 2016): E172-E181. Full Text
  - Chen, Z, Lan, X, Wu, D, Sunkel, B, Ye, Z, Huang, J, Liu, Z, Clinton, SK, Jin, VX, and Wang, Q. "Ligand-dependent genomic function of glucocorticoid receptor in triple-negative breast cancer." Nature Communications 6, no. 1 (December 2015). Full Text
  - Kamrava, M, Kishan, AU, Margolis, DJ, Huang, J, Dorey, F, Lieu, P, Kupelian, PA, and Marks, LS. "Multiparametric magnetic resonance imaging for prostate cancer improves Gleason score assessment in favorable risk prostate cancer." Practical Radiation Oncology 5, no. 6 (November 2015): 411-416. Full Text
  - Rakow-Penner, RA, White, NS, Margolis, DJA, Parsons, JK, Schenker-Ahmed, N, Kuperman, JM, Bartsch, H, Choi, HW, Bradley, WG, Shabaik, A, Huang, J, Liss, MA, Marks, L, Kane, CJ, Reiter, RE, Raman, SS, Karow, DS, and Dale, AM. "Prostate diffusion imaging with distortion correction." Magnetic Resonance Imaging 33, no. 9 (November 2015): 1178-1181. Full Text
  - Wang, D, Liu, X, Hsieh, B, Bruce, R, Somlo, G, Huang, J, and Sambucetti, L. "Exploring Glycan Markers for Immunotyping and Precision-targeting of Breast Circulating Tumor Cells." Archives of Medical Research 46, no. 8 (November 2015): 642-650. Full Text
  - Chen, J-F, Ho, H, Lichterman, J, Lu, Y-T, Zhang, Y, Garcia, MA, Chen, S-F, Liang, A-J, Hodara, E, Zhau, HE, Hou, S, Ahmed, RS, Luthringer, DJ, Huang, J, Li, K-C, Chung, LWK, Ke, Z, Tseng, H-R, and Posadas, EM. "Subclassification of prostate cancer circulating tumor cells by nuclear size reveals very small nuclear circulating tumor cells in patients with visceral metastases." Cancer 121, no. 18 (September 15, 2015): 3240-3251. Full Text
  - Liu, X, Chen, X, Rycaj, K, Chao, H-P, Deng, Q, Jeter, C, Liu, C, Honorio, S, Li, H, Davis, T, Suraneni, M, Laffin, B, Qin, J, Li, Q, Yang, T, Whitney, P, Shen, J, Huang, J, and Tang, DG. "Systematic dissection of phenotypic, functional, and tumorigenic heterogeneity of human prostate cancer cells." Oncotarget 6, no. 27 (September 15, 2015). Full Text
  - Gan, W, Dai, X, Lunardi, A, Li, Z, Inuzuka, H, Liu, P, Varmeh, S, Zhang, J, Cheng, L, Sun, Y, Asara, JM, Beck, AH, Huang, J, Pandolfi, PP, and Wei, W. "SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression." Molecular Cell 59, no. 6 (September 2015): 917-930. Full Text
  - Scafoglio, C, Hirayama, BA, Kepe, V, Liu, J, Ghezzi, C, Satyamurthy, N, Moatamed, NA, Huang, J, Koepsell, H, Barrio, JR, and Wright, EM. "Functional expression of sodium-glucose transporters in cancer." Proceedings of the National Academy of Sciences 112, no. 30 (July 28, 2015): E4111-E4119. Full Text
  - Tsao, C-K, Gray, KP, Nakabayashi, M, Evan, C, Kantoff, PW, Huang, J, Galsky, MD, Pomerantz, M, and Oh, WK. "Patients with Biopsy Gleason 9 and 10 Prostate Cancer Have Significantly Worse Outcomes Compared to Patients with Gleason 8 Disease." The Journal of Urology 194, no. 1 (July 2015): 91-97. Full Text
  - Peek, EM, Song, W, Zhang, H, Huang, J, and Chin, AI. "Loss of MyD88 leads to more aggressive TRAMP prostate cancer and influences tumor infiltrating lymphocytes." The Prostate 75, no. 5 (April 2015): 463-473. Full Text
  - Escamilla, J, Schokrpur, S, Liu, C, Priceman, SJ, Moughon, D, Jiang, Z, Pouliot, F, Magyar, C, Sung, JL, Xu, J, Deng, G, West, BL, Bollag, G, Fradet, Y, Lacombe, L, Jung, ME, Huang, J, and Wu, L. "CSF1 Receptor Targeting in Prostate Cancer Reverses Macrophage-Mediated Resistance to Androgen Blockade Therapy." Cancer Research 75, no. 6 (March 15, 2015): 950-962. Full Text
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  - Goldstein, AS, Huang, J, Guo, C, Garraway, IP, and Witte, ON. "Identification of a Cell of Origin for Human Prostate Cancer." Science 329, no. 5991 (July 30, 2010): 568-571. Full Text
  - Marks, LS, and Huang, J. "Re: Copy number analysis indicates monoclonal origin of lethal metastatic prostate cancer." European Urology 57, no. 4 (April 2010): 727-728. Full Text
  - Huang, J, and Witte, ON. "A Seminal Finding for Prostate Cancer?." New England Journal of Medicine 362, no. 2 (January 14, 2010): 175-176. Full Text
  - Lawson, DA, Zong, Z, Memarzadeh, S, Xin, L, Huang, J, and Witte, ON. "Basal epithelial stem cells are efficient targets for prostate cancer initiation." Proceedings of the National Academy of Sciences of USA 107 (2010): 2610-2615.
  - Memarzadeh, S, Zong, Y, Janzen, DM, Goldstein, AS, Cheng, D, Kurita, T, Schafenacker, AM, Huang, J, and Witte, ON. "Cell-autonomous activation of the PI3-kinase pathway initiates endometrial cancer from adult uterine epithelium." Proceedings of the National Academy of Sciences of USA , no. 107 (2010): 17298-17303.
  - Silvers, CR, Williams, K, Salamone, L, Huang, J, Jordan, CT, Zhou, H, and Palapattu, GS. "A novel in vitro assay of human prostate cancer tumor initiation." Prostate 70 (2010): 1379-1387.
  - Tanaka, H, Kono, E, Tran, CP, Miyazaki, H, Yamashiro, J, Shimomura, T, Ladan, F, Wada, R, Huang, J, Vessella, RL, An, J, Horvath, S, Gleave, M, Retting, MB, Wainberg, ZA, and Reiter, RE. "Monoclonal antibody targeting of N-cadherin inhibits prostate cancer growth, invasion, metastasis and castration resistance." Nature Medicine 16 (2010): 1414-1420.
  - Palapattu, GS, Wu, C, Silvers, CR, Martin, HB, Williams, K, Salamone, L, Bushnell, T, Huang, L-S, Yang, Q, and Huang, J. "Selective expression of CD44, a putative prostate cancer stem cell marker, in neuroendocrine tumor cells of human prostate cancer." The Prostate 69, no. 7 (May 15, 2009): 787-798. Full Text
  - Simon, RA, di Sant'Agnese, PA, Huang, L-S, Xu, H, Yao, JL, Yang, Q, Liang, S, Liu, J, Yu, R, Cheng, L, Oh, WK, Palapattu, GS, Wei, J, and Huang, J. "CD44 expression is a feature of prostatic small cell Carcinoma and Distinguishes it from its Mimickers." Human Pathology 40, no. 2 (February 2009): 252-258. Full Text
  - Huang, J, Lee, P, Mikami, Y, and Melamed, J. "Dysplastic ("in-situ") Lesions in multifocal renal oncocytomas (oncocytosis)." International Journal of Clinical and. Experimental Pathology 2 (2009): 583-587.
  - Sun, Y, Niu, J, and Huang, J. "Neuroendocrine differentiation in prostate cancer." American Journal of Translational Research 1 (2009): 148-162.
  - Deng, X, Liu, H, Huang, J, Cheng, L, Keller, ET, Parsons, SJ, and Hu, C-D. "Ionizing Radiation Induces Prostate Cancer Neuroendocrine Differentiation through Interplay of CREB and ATF2: Implications for Disease Progression." Cancer Research 68, no. 23 (December 1, 2008): 9663-9670. Full Text
  - Li, L, Xu, H, Spaulding, BO, Cheng, L, Simon, R, Yao, JL, di Sant'Agnese, PA, Bourne, PA, and Huang, J. "Expression of RNA-binding protein IMP3 (KOC) in benign urothelium and urothelial tumors." Human Pathology 39, no. 8 (August 2008): 1205-1211. Full Text
  - Gobbo, S, Eble, JN, Huang, J, Grignon, DJ, Wang, M, Martignoni, G, Brunelli, M, and Cheng, L. "Schwannoma of the Kidney." Modern Pathology 21, no. 6 (June 2008): 779-783. Full Text
  - Yao, JL, Huang, J, and Anthony di Sant’Agnese, P. "Small cell carcinoma of the prostate." Diagnostic Histopathology 14, no. 3 (March 2008): 117-121. Full Text
  - Cai, Y, Lee, Y-F, Li, G, Liu, S, Bao, B-Y, Huang, J, Hsu, CL, and Chang, C. "A new prostate cancer therapeutic approach: combination of androgen ablation with COX-2 inhibitor." International Jouranl of Cancer 123 (2008): 195-201.
  - Johnson, AM, O'Connell, MJ, Miyamoto, H, Huang, J, Yao, JL, Messing, EM, and Reeder, JE. "Androgenic dependence of exophytic tumor growth in a transgenic mouse model of bladder cancer: a role for thrombospondin-1." BMC Urology 8, no. 7 (2008).
  - Lei, JL, and Huang, J. "Cytoplasmic staining of TTF-1 in the differential diagnosis of hepatocellular carcinoma." Expert Opinion on Medical Diagnostics 2 (2008): 151-159.
  - Li, L, Yao, JL, di Sant' Agnese, PA, Bourne, PA, Picken, MM, Young, AN, Shen, SS, and Huang, J. "Expression of Claudin-7 in Benign Kidney and Kidney Tumors." International Journal of Clinical and. Experimental Pathology 1 (2008): 57-64.
  - Liu, B, Yu, H-MI, Huang, J, and Hsu, W. "Co-opted Jnk/Sapk signaling in Wnt/b-catenin-induced tumorigenesis." Neoplasia 10 (2008): 1004-1013.
  - Ross, RW, Beer, TM, Jacobus, S, Bubley, GT, Taplin, M-E, Ryan, C, Huang, J, and Oh, WK. "A Phase II study of carboplatin plus docetaxel in men with metastatic hormone refractory prostate cancer who are refractory to docetaxel." Cancer 112 (2008): 521-526.
  - Ross, RW, Beer, TM, Jacobus, S, Bubley, GT, Taplin, M-E, Ryan, C, Huang, J, and Oh, WK. "A Phase II study of carboplatin plus docetaxel in men with metastatic hormone refractory prostate cancer who are refractory to docetaxel." Cancer 112 (2008): 521-526.
  - Simon, RA, di Sant' Agnese, PA, Palapattu, GS, Singer, E, Candelario, G, Huang, J, and Yao, JL. "Mucinous Tubular and Spindle Cell Carcinoma of the Kidney with Sarcomatoid Differentiation." International Journal for Computer Assisted Radiology and Surgery 1 (2008): 180-184.
  - Hui, P, Wang, HL, Chu, P, Yang, B, Huang, J, Baergen, RN, Sklar, J, Yang, XJ, and Soslow, RA. "Absence of Y chromosome in human placental site trophoblastic tumor." Modern Pathology 20, no. 10 (October 2007): 1055-1060. Full Text
  - Oh, WK, Tay, M-H, and Huang, J. "Is there a role for platinum chemotherapy in the treatment of patients with hormone-refractory prostate cancer?." Cancer 109, no. 3 (February 1, 2007): 477-486. Full Text
  - Bhatt, S, Huang, J, and Dogra, VS. "Littoral cell angioma of spleen: Radiologic-pathologic correlation." AJR. American journal of roentgenology 188, no. 5 (2007): 1365-1366.
  - Cheng, L, Zhang, S, Wang, M, Davidson, DD, Morton, MJ, Huang, J, Zheng, S, Jones, TD, Beck, SD, and Foster, RS. "Molecular Genetic Evidence Supporting the Neoplastic Nature of Stromal Cells in “Fibrosis” After Chemotherapy for Testicular Germ Cell Tumors." American Journal of Pathology 213 (2007): 65-71.
  - Huang, J, Liang, JJ, Wang, Z, Chiriboga, L, Greco, MA, Shapiro, E, Huang, H, Peng, Y, Melamed, J, Garabedian, M, and Lee, P. "The expression and function of androgen receptor coactivator p44 and protein arginine methyltransfersase 5 (PRMT5) in the developing testis and testicular tumors." Journal of Urology 177, no. 5 (2007): 1918-1922.
  - Huang, J, Wu, C, di Sant'Agnese, PA, Yao, JL, Cheng, L, and Na, Y. "Function and molecular mechanisms of neuroendocrine cells in prostate cancer." Analytical and quantitative cytology and histology / the International Academy of Cytology [and] American Society of Cytology 29 (2007): 128-138.
  - Podder, TK, Sherman, J, Li, L, Joseph, J, Rubens, DR, Messing, EM, Huang, J, and Yu, Y. "Mechanical properties of human prostate tissue in the context of surgical needle insertion." International Journal for Computer Assisted Radiology and Surgery 2, no. Suppl I (2007): S106-S108.
  - Wagner, D, Joseph, J, Huang, J, and Xu, H. "Malakoplakia of the Prostate on Needle Core Biopsy: A Case Report and Review of the Literature." International Journal of Surgical Pathology 15, no. 1 (January 2007): 86-89. Full Text
  - Wagner, DG, Yao, JL, di Sant'Agnese, PA, Cheng, L, Lopez-Beltran, A, Montironi, R, and Huang, J. "Soft tissue tumors in the prostate." Analytical and quantitative cytology and histology / the International Academy of Cytology [and] American Society of Cytology 29 (2007): 341-350.
  - Wu, C, and Huang, J. "PI3 kinase-AKT-mTOR pathway is involved in neuroendocrine differentiation of prostate cancer." The Journal of biological chemistry 282, no. 6 (2007): 3571-3583.
  - Huang, J, Yao, JL, di Sant'Agnese, PA, Yang, Q, Bourne, PA, and Na, Y. "Immunohistochemical characterization of neuroendocrine cells in prostate cancer." The Prostate 66, no. 13 (September 15, 2006): 1399-1406. Full Text
  - Johnson, AM, Conover, DL, Huang, J, Messing, EM, Ning, R, O’Connell, MJ, Rossi, MA, Sun, T-T, Wood, RW, Wu, X-R, and Reeder, JE. "Early detection and measurement of urothelial tumors in mice." Urology 67, no. 6 (June 2006): 1309-1314. Full Text
  - Yao, JL, Madeb, R, Bourne, P, Lei, J, Yang, X, Tickoo, S, Liu, Z, Tan, D, Cheng, L, Hatem, F, Huang, J, and Anthony di SantʼAgnese, P. "Small Cell Carcinoma of the Prostate: An Immunohistochemical Study." The American Journal of Surgical Pathology 30, no. 6 (June 2006): 705-712. Full Text
  - Lei, J, Bourne, PA, di Sant'Agnese, PA, and Huang, J. "Cytoplasmic staining of TTF-1 in the differential diagnosis of hepatocellular carcinoma versus cholangiocarcinoma and metastatic carcinoma of the liver." American Journal of Clinical Pathology 125 (2006): 519-525.
  - Markhardt, KB, Rubens, DJ, Huang, J, and Dogra, VS. "Sonographic features of Biliary Hamartomas with histopathological correlation." Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine 25 (2006): 1631-1633.
  - Sun, Y, Gao, D, Liu, Y, Huang, J, Lessnick, S, and Tanaka, S. "IGF2 is critical for tumorigenesis by synovial sarcoma oncoprotein SYT-SX1." Oncogene 25 (2006): 1042-1052.
  - Wu, C, Yao, JL, Di Sant'Agnese, PA, Na, Y, and Huang, J. "Neuroendocrine differentiation in prostate cancer." Zhonghua bing li xue za zhi Chinese journal of pathology 35 (2006): 565-567.
  - Wu, C, Zhang, L, Bourne, PA, Reeder, JE, di Sant'Agnese, PA, Yao, JL, Nia, Y, and Huang, J. "Protein tyrosine phosphatase PTP1B is involved in neuroendocrine differentiation of prostate cance." Prostate 66 (2006): 1125-1135.
  - Zang, Z, Rosen, DG, Yao, JL, Huang, J, and Liu, J. "Expression of p14(ARF), p15(INK4b), p16(INK4a), and DCR2 increases during prostate cancer progression." Modern Pathology 19 (2006): 1339-1343.
  - Li, H, Zhang, L, Lou, H, Ding, I, Kim, S, Wang, L, Huang, J, Di Sant’Agnese, PA, and Lei, J-Y. "Overexpression of Decoy Receptor 3 in Precancerous Lesions and Adenocarcinoma of the Esophagus." American Journal of Clinical Pathology 124, no. 2 (August 2005): 282-287. Full Text
  - Li, R, Ni, J, Bourne, PA, Yeh, S, Yao, J, di Sant'Agnese, PA, and Huang, J. "Cell Culture Block Array for Immunocytochemical Study of Protein Expression in Cultured Cells." Applied Immunohistochemistry & Molecular Morphology 13, no. 1 (March 2005): 85-90. Full Text
  - Huang, J, Wu, C, Yao, JL, and di Sant'Agnese, PA. "Neuroendocrine differentiation in prostate cancer." Edited by BQ Wu. Proceedings of the 4th Asian-Pacific International Academy of Pathology Congress (2005): 57-61.
  - Huang, J, Yao, JL, Zhang, L, Bourne, PA, Quinn, AM, di Sant'Agnese, PA, and Reeder, JE. "Differential expression of Interleukin-8 and its receptors in the neuroendocrine and non-neuroendocrine compartments of prostate cancer." American Journal of Pathology 166 (2005): 1807-1815.
  - Hu, Y-C, Yeh, S, Yeh, S-D, Sampson, ER, Huang, J, Li, P, Hsu, C-L, Ting, H-J, Lin, H-K, Wang, L, Kim, E, Ni, J, and Chang, C. "Functional Domain and Motif Analyses of Androgen Receptor Coregulator ARA70 and Its Differential Expression in Prostate Cancer." Journal of Biological Chemistry 279, no. 32 (August 6, 2004): 33438-33446. Full Text
  - Patton, KT, Tretiakova, MS, Yao, JL, Papavero, V, Huo, L, Adley, BP, Wu, G, Huang, J, Pins, MR, Teh, BT, and Yang, XJ. "Expression of RON Proto-oncogene in Renal Oncocytoma and Chromophobe Renal Cell Carcinoma." The American Journal of Surgical Pathology 28, no. 8 (August 2004): 1045-1050. Full Text
  - Li, R, Yao, JL, Bourne, PA, di Sant'agnese, PA, and Huang, J. "Frequent expression of human carcinoma-associated antigen (HCA), a mucin-type glycoprotein, by cells of prostatic carcinom." Archives of Pathology & Laboratory Medicine 128 (2004): 1412-1417.
  - Liang, S, Yao, JL, Bourne, PA, di Sant'Agnese, PA, Huang, J, and Lei, J. "Over-Expression of Human Carcinoma-Associated Antigen in Esophageal Adenocarcinoma and its Precursor Lesions." American Journal of Clinical Pathology 122 (2004): 747-751.
  - Yao, JL, Bourne, PA, Yang, Q, di Sant'Agnese, PA, and Huang, J. "Overexpression of Human Carcinoma-Associated Antigen (HCA) in Urothelial Carcinoma of the Bladder." Archives of Pathology & Laboratory Medicine 128 (2004): 785-787.
  - Chen, TS, McNally, M, Hulbert, W, di Sant'Agnese, PA, and Huang, J. "Renal Oncocytosis Presenting in Childhood: A Case Report." International Journal of Surgical Pathology 11, no. 4 (October 2003): 325-329. Full Text
  - Daiss, J, Carney, J, Cartun, R, Codington, J, Erdrich, C, Hinchman, C, Huang, J, Mauck, J, and Schnipelsky, P. "Human Carcinoma Antigen: A Marker Useful for Discriminating between Benign Prostatic Hyperplasia and Prostate Cancer." Journal of Clinical Ligand Assay 26 (2003): 177-180.
  - Ni, J, Chen, M, Zhang, Y, Li, R, Huang, J, and Yeh, S. "Vitamin E succinate inhibits human prostate cancer cell growth via modulating cell cycle regulatory machinery." Biochemical and Biophysical Research Communications 300, no. 2 (January 2003): 357-363. Full Text
  - Huang, J, Behrens, C, Wistuba, II, Gazdar, AF, and Jagirdar, J. "Clonality of combined tumors: A molecular genetic study." Archives of Pathology & Laboratory Medicine 126 (2002): 437-441.
  - Lee, Y-F, Lin, W-J, Huang, J, Messing, EM, Chan, FL, Wilding, G, and Chang, C. "Activation of Mitogen-activated Protein Kinase Pathway by the Antiandrogen Hydroxyflutamide in Androgen Receptor-negative Prostate Cancer Cells." Cancer Research 62 (2002): 6039-6042.
  - Liu, Z, Huang, J, Yan, Z, and Tan, J. "Application of flow cytometry in the diagnosis and differential disgnosis of lymphoma and leukemia." Zhonghua bing li xue za zhi Chinese journal of pathology 31 (2002): 352-353.
  - Huang, J, Behrens, C, Wistuba, I, Gazdar, AF, and Jagirdar, J. "Molecular analysis of synchronous and metachronous tumors of the lung: Impact on management and prognosis." Annals of Diagnostic Pathology 5, no. 6 (December 2001): 321-329. Full Text
  - Gu, M, Shi, W, Huang, J, Barakat, RR, Thaler, HT, and Saigo, PE. "Association between initial diagnostic procedure and hysteroscopy and abnormal peritoneal washings in patients with endometrial carcinoma." Cancer 90, no. 3 (June 25, 2000): 143-147. Full Text
  - SARIC, M, APPLEBAUM, RM, CULLIFORD, AT, HUANG, J, SCHOLES, JV, and KRONZON, I. "Massive Atrial Septal Lipomatous Hypertrophy." Echocardiography 16, no. 8 (November 1999): 833-834. Full Text
  - Huang, J, Mohammadi, M, Rodrigues, GA, and Schlessinger, J. "Reduced activation of RAF-1 and MAP kinase by a fibroblast growth factor receptor mutant deficient in stimulation of phosphatidylinositol hydrolysis." The Journal of biological chemistry 270 (1995): 5065-5072.
  - Trachman, JD, Huang, J, and Reem, GH. "Activation of human thymocytes induces the phosphorylation of protein tyrosine phosphatase IC." Comptes rendus de l'Académie des Sciences Paris de la vie/Life Sciences 318 (1995): 367-374.
  - Spivak-Kroizman, T, Lemmon, M, Dikic, I, Ladbury, J, Pinchasi, D, Huang, J, Jaye, M, Crumley, G, Schlessinger, J, and Lax, I. "Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation." Cell 79, no. 6 (December 1994): 1015-1024. Full Text
  - Huang, J. "Internalization of fibroblast growth factor receptor is inhibited by a point mutation at tyrosine 766." The Journal of biological chemistry 269 (1994): 17056-17061.
  - Vogel, W, Lammers, R, Huang, J, and Ullrich, A. "Activation of a phosphotyrosine phosphatase by tyrosine phosphorylation." Science 259, no. 5101 (March 12, 1993): 1611-1614. Full Text
  - Levy, JB, Canoll, PD, Silvennoinen, O, Barnea, G, Morse, B, Honegger, AM, Huang, J, Cannizzaro, LA, Park, SH, Druck, T, Huebner, K, Barnea, G, Sap, J, and Schlessinger, J. "The cloning of a receptor-type protein tyrosine phosphatase expressed in the central nervous system." The Journal of biological chemistry 268 (1993): 10573-1081.
  - Huang, J, and Schneider, RJ. "Adenovirus inhibition of cellular protein synthesis involves inactivation of cap-binding protein." Cell 65, no. 2 (April 1991): 271-280. Full Text
  - Dolph, PJ, Huang, J, and Schneider, RJ. "Translation by the adenovirus tripartite leader: elements which determine independence from cap-binding protein complex." Journal of virology 64 (1990): 2669-2677.
  - Huang, J, and Schneider, RJ. "Adenovirus inhibition of cellular protein synthesis is prevented by the drug 2-aminopurine." Proceedings of the National Academy of Sciences of the United States of America 87, no. 18 (1990): 7115-7119.
  - Huang, J, and Tang, Z. "Measurement of estrogen receptor in the nuclei of bone marrow cells of male mice after the administration of estrogen." Bulletin of the Academy of Military Medical Sciences 2 (1988): 24-26.
  - Guo, S, Sun, F, Guo, Z, Li, W, Alfano, A, Chen, H, Magyar, CE, Huang, J, Chai, TC, Qiu, S, and Qiu, Y. "Tyrosine Kinase ETK/BMX Is Up-Regulated in Bladder Cancer and Predicts Poor Prognosis in Patients with Cystectomy(Published online)." Plos One 6, no. 3: e17778-e17778. Full Text
  - Hu, C-D, Choo, R, and Huang, J. "Neuroendocrine Differentiation in Prostate Cancer: A Mechanism of Radioresistance and Treatment Failure(Published online)." Frontiers in Oncology 5. Full Text
  - Liss, MA, White, NS, Parsons, JK, Schenker-Ahmed, NM, Rakow-Penner, R, Kuperman, JM, Bartsch, H, Choi, HW, Mattrey, RF, Bradley, WG, Shabaik, A, Huang, J, Margolis, DJA, Raman, SS, Marks, LS, Kane, CJ, Reiter, RE, Dale, AM, and Karow, DS. "MRI-Derived Restriction Spectrum Imaging Cellularity Index is Associated with High Grade Prostate Cancer on Radical Prostatectomy Specimens(Published online)." Frontiers in Oncology 5. Full Text
  - Yuan, P, Kadara, H, Behrens, C, Tang, X, Woods, D, Solis, LM, Huang, J, Spinola, M, Dong, W, Yin, G, Fujimoto, J, Kim, E, Xie, Y, Girard, L, Moran, C, Hong, WK, Minna, JD, and Wistuba, II. "Sex Determining Region Y-Box 2 (SOX2) Is a Potential Cell-Lineage Gene Highly Expressed in the Pathogenesis of Squamous Cell Carcinomas of the Lung(Published online)." Plos One 5, no. 2: e9112-e9112. Full Text
- Book Sections
  - Koo, J, Filson, CP, Huang, J, and Pantuck, AJ. "Collecting Duct Carcinoma and Renal Medullary Carcinoma." In The Kidney: A Comprehensive Guide to Pathologic Diagnosis and Management, edited by DE Hansel, CJ Kane, GP Paner, and S Chang, 109-123. 2016. (Chapter)
  - Brick, A, Niu, J, Huang, J, and Oh, WK. "Possibility for Platinum Chemotherapy Treatment for HRPC Patients?." In Drug Management of Prostate Cancer, edited by WD Figg, CH Chau, and EJ Small, 153-161. NJ: Humana Press, 2010. (Chapter)
  - Wu, C, Chen, G, Na, Y, Xin, D, Yao, JL, di Xant' Agnese, PA, and Huang, J. "The function of Interleukin-8 in prostate cancer." In Progress in Chemokine Research, edited by WP Links, 149-156. New York: Nova Science Publishers, 2007. (Chapter)
  - Huang, J, Yao, JL, and di Sant'Agnese, PA. "Neuroendocrine Differentiation in Prostate Cancer." In Prostate Cancer: Principles and Practice, edited by R Kirby, AW Partin, M Feneley, and JK Parsons, 143-150. London, UK: Martin Dunitz Ltd (Taylor & Francis Group), 2005. (Chapter)
  - Huang, J, and di Sant' Agnese, PA. "Neuroendocrine Differentiation in Prostate Cancer: An Overview." In Advances in Oncology: The Expanding Role of Octreotide I, edited by SWJ Lamberts and L Dogliotti, 243-262. Bristol, UK: BioScientifica Ltd, 2002. (Chapter)
- Digital Publications
  - Wagner, DG, and Huang, J. "Small Cell Carcinoma of the Prostate." (April 20, 2009). Link to Item
- Conference Papers
  - Liu, Y-N, Chen, W-Y, Tsai, Y-C, Yeh, H-L, Suau, F, and Huang, J. "Androgen deprivation therapy-induced TGFBI signaling promotes EMT and bone metastasis of prostate cancer." AACR Special Conference on Prostate Cancer - Advances in Basic, Translational, and Clinical Research. Orlando, FL. December 2, 2017 - December 5, 2017.: AMER ASSOC CANCER RESEARCH, August 1, 2018. Link to Item
  - Aggarwal, RR, Zhang, L, Beer, TM, Youngren, J, Stromlund, A, Bell, A, Foye, A, Playdle, D, Alumkal, JJ, Reiter, RE, Gleave, M, Evans, CP, Thomas, GV, Huang, J, True, LD, Rettig, M, Lara, P, Chi, KN, and Small, EJ. "Serum neuroendocrine (NE) markers and clinical characteristics of treatment-emergent small cell neuroendocrine prostate cancer (t-SCNC) in men with metastatic castration resistant prostate cancer (mCRPC): Data from the West Coast Prostate Cancer Dream Team." : American Society of Clinical Oncology (ASCO), February 20, 2018. Full Text
  - Huang, J, Yin, Y, Thomas, G, True, L, Beer, TM, Gleeve, M, Witte, O, Stuart, J, Evans, C, Foye, A, Youngren, J, and Small, E. "Histologic Spetrum of Metastatic Castration-Resistant Prostate Cancer." 106th Annual Meeting of the United-States-and-Canadian-Academy-of-Pathology (USCAP). San Antonio, TX. March 4, 2017 - March 10, 2017.: NATURE PUBLISHING GROUP, February 1, 2017. Link to Item
  - Huang, J, Yin, Y, Thomas, G, True, L, Beer, TM, Gleeve, M, Witte, O, Stuart, J, Evans, C, Foye, A, Youngren, J, and Small, E. "Histologic Spetrum of Metastatic Castration-Resistant Prostate Cancer." 106th Annual Meeting of the United-States-and-Canadian-Academy-of-Pathology (USCAP). San Antonio, TX. March 4, 2017 - March 10, 2017.: NATURE PUBLISHING GROUP, February 1, 2017. Link to Item
  - Samaratunga, H, Montrironi, R, True, L, Epstein, JI, Griffiths, DF, Humphrey, PA, van der Kwast, T, Wheeler, TM, Srigley, JR, Delahunt, B, Egevad, L, and ISUP Prostate Cancer Group, . "Working group 1: specimen handling." International Society of Urological Pathology (ISUP) Consensus Conference on Handling and Staging of Radical Prostatectomy Specimens. Nature Publishing Group, 2011.
  - Samaratunga, H, Montrironi, R, True, L, Epstein, JI, Griffiths, DF, Humphrey, PA, van der Kwast, T, Wheeler, TM, Srigley, JR, Delahunt, B, Egevad, L, and ISUP Prostate Cancer Group, . "Working group 1: specimen handling." International Society of Urological Pathology (ISUP) Consensus Conference on Handling and Staging of Radical Prostatectomy Specimens. Nature Publishing Group, 2011.
Teaching & Mentoring
Recent Courses
- PATHOL 293: Research Independent Study 2019
- PATHOL 793: Research Independent Study 2018

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Education, Training, & Certifications

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Digital Publications

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