Jiaoti Huang | Scholars@Duke

Jiaoti Huang
Endowed Department Chair of Pathology

I am a physician-scientist with clinical expertise in the pathologic diagnosis of genitourinary tumors including tumors of the prostate, bladder, kidney and testis. Another area of interest is gynecologic tumors. In my research laboratory we study prostate cancer, focusing on molecular mechanisms of carcinogenesis and tumor progression, as well as biomarkers, imaging and novel therapeutic strategies. In addition to patient care and research, I am also passionate about education. I have trained numerous residents, fellows, graduate students and postdocs.

Current Appointments & Affiliations

Endowed Department Chair of Pathology, Pathology, Clinical Science Departments 2017
Professor of Pathology, Pathology, Clinical Science Departments 2016
Chair, Department of Pathology, Pathology, Clinical Science Departments 2016
Professor of Pharmacology and Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2017
Professor of Cell Biology, Cell Biology, Basic Science Departments 2022
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2016

Contact Information

Background
Education, Training, & Certifications
- Ph.D., New York University 1991
- M.D., Anhui Medical University (China) 1983
Previous Appointments & Affiliations
- Instructor, Temporary in the Department of Pathology, Pathology, Clinical Science Departments 2015
Recognition
In the News
- MAR 7, 2023 School of Medicine
  
  A New Avenue for Prostate Cancer Treatment
- JAN 18, 2022 Duke Health News
  
  Early Prostate Cancers Can Harbor Aggressive Tumor Cells
- MAR 23, 2021 Duke Health News
  
  Duke Research Points to New Therapy Approach to Cut Off Prostate Cancer's Fuel Source
- DEC 5, 2019 Duke Health News
  
  Drug Tested in Lab Studies Halts Prostate Cancer Cells That Are Impervious to Hormone Therapy
Research
Selected Grants
- Developing A Novel Combinatorial Therapy for Lethal Neuroendocrine Prostate Cancer awarded by National Institutes of Health 2022 - 2027
- Targeting Ferroptosis in Lethal RB1 Deficient Prostate Cancer awarded by National Institutes of Health 2022 - 2027
- Engineering Large Chromosomal Deletions in Mice to Advance Precision Oncology for Prostate Cancer awarded by National Institutes of Health 2022 - 2027
- Glutaminase I isoforms as personalized biomarkers of prostate cancer awarded by National Institutes of Health 2022 - 2026
- Targeting NUAK2 in neuroendocrine prostate cancer awarded by Department of Defense 2023 - 2026
- Cell and Molecular Biology Training Program awarded by National Institutes of Health 2021 - 2026
- Targeting oncogenomic function of N-Myc to inhibit neuroendocrine prostate cancer visceral metastasis awarded by Department of Defense 2023 - 2026
- Defining Cellular and Genetic Factors for Renal Cell Carcinoma Subtypes awarded by Department of Defense 2022 - 2025
- Targeting convergent oncogenic signaling during AR inhibition to overcome metastasis and immune evasion in prostate cancer awarded by National Institutes of Health 2019 - 2025
- Exploitation of a new targetable node in the AR signaling pathway in prostate cancer awarded by Department of Defense 2022 - 2025
- PRMT5/MEP50 as a critical epigenetic regulator and therapeutic target for therapy-induced neuroendocrine prostate cancer awarded by Purdue University 2022 - 2025
- Role of JMJD1A modifications in castration resistance of prostate cancer awarded by University of Maryland, Baltimore 2022 - 2025
- Transcriptional reprogramming of lethal small cell prostate cancer awarded by Department of Defense 2021 - 2024
- Targeting NUAK2 to mitigate obesity-enhanced prostate cancer growth and metastasis awarded by Department of Defense 2021 - 2024
- Preclinical studies of DRP-104 in targeting glutamine metabolism of prostate cancer awarded by Dracen Pharmaceuticals 2022 - 2024
- Targeting neuroendocrine prostate cancer by engineering 3' untranslated regions awarded by Department of Defense 2020 - 2024
- Duke CTSA (TL1) Year 5 awarded by National Institutes of Health 2018 - 2024
- Targeting glutamine utilization in therapy-resistant prostate cancer awarded by Department of Defense 2021 - 2024
- Interrupting the aberrant cancer development sequence in epithelial cancer progression awarded by Prostate Cancer Foundation 2021 - 2024
- Heat Shock Factor 1 drives prostate cancer progression through production of antioxidants and cellular energy awarded by Department of Defense 2021 - 2023
- A novel mitotic regulatory axis in neuroendocrine prostate cancer awarded by University of Pittsburgh 2019 - 2023
- Role and targeting of PRMT5 in prostate cancer awarded by Purdue University 2017 - 2023
- Confirmation of histologic SCNC (NEPC) awarded by BioXcel Therapeutics 2019 - 2023
- Targeting RNA splicing in race-related aggressive and lethal prostate cancer awarded by Prostate Cancer Foundation 2018 - 2022
- Targeting Glutaminase Isoforms for Therapy-Resistant Prostate Cancer awarded by Department of Defense 2019 - 2022
- Defining the Essential Determinants of Prostate Cancer Differentiation States awarded by National Institutes of Health 2019 - 2022
- Targeting the p38/Snail/PD-L1 axis in hormone-therapy resistance and metastasis awarded by Department of Defense 2018 - 2022
- Role of oncogenic phosphorylated MED1 in aggressive prostate cancer awarded by National Institutes of Health 2017 - 2022
- Targeting castration-resistant prostate cancer by engineering 3'UTR awarded by Department of Defense 2020 - 2022
- Unveiling the roles of neuroendocrine cells in prostate cancer development awarded by Mike Slive Foundation 2020 - 2021
- Novel Tumor Suppressive Role of Phosphodiesterases in Prostate Cancer awarded by Department of Defense 2016 - 2021
- Histologic and Immunohistochemical Biomarkers for Heavily Treated Metastatic Prostate Cancer awarded by National Institutes of Health 2016 - 2021
- Assessment of macrophage density in historical tNEPC tissue samples. awarded by BioXcel Therapeutics 2019 - 2021
- Identification of DNA methylation markers for risk of metastasis in localized prostate cancer awarded by Kaiser Permanente 2016 - 2020
- Heparan sulfate in prostate cancer awarded by University of South Florida 2019 - 2020
- Targeting Adaptive Pathways in Abiraterone- and Enzalutamide-Refractory Intermediate Atypical Carcinoma awarded by University of California - San Francisco 2016 - 2019
- Role of the Stroma in Fibrolamellar Hepatocellular Carcinoma awarded by Fibrolamellar Cancer Foundation 2016 - 2019
- Genetic screen of calorie restricted and western diet essential kinases in prostate cancer awarded by Prostate Cancer Foundation 2018 - 2019
- Heparan sulfate in prostate cancer awarded by University of Georgia 2018
- Paired Acquisition In Refractory Prostate Cancer (PAIR): Advancing the Promise of the PCF/SU2C/AACR West Coast Prostate Cancer Dream Team awarded by University of California - San Francisco 2016 - 2018
- A novel strategy to identify prostate cancer biomarkers for patient management awarded by National Institutes of Health 2013 - 2018
- Systems Analysis of Epigenomic Architecture in Cancer Progression awarded by University of Texas Health Science Center at San Antonio 2017 - 2018
- : Identification of DNA methylation markers for risk of metastasis in localized prostate cancer awarded by Kaiser Permanente 2016
- Stand Up 2 Cancer West Coast Dream Team Grant awarded by University of San Francisco 2013 - 2016
External Relationships
- Artera
- Gencode
- Kingmed Diagnostics
- MoreHealth
- OptraScan
- SISU Pharma
- York Biotechnology
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Chen, Wei-Yu, Phan Vu Thuy Dung, Hsiu-Lien Yeh, Wei-Hao Chen, Kuo-Ching Jiang, Han-Ru Li, Zi-Qing Chen, et al. “Targeting PKLR/MYCN/ROMO1 signaling suppresses neuroendocrine differentiation of castration-resistant prostate cancer.” Redox Biol 62 (June 2023): 102686. https://doi.org/10.1016/j.redox.2023.102686.
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  - Cheng, Qing, William Butler, Yinglu Zhou, Hong Zhang, Lu Tang, Kathryn Perkinson, Xufeng Chen, et al. “Erratum to "Pre-existing Castration-resistant Prostate Cancer-like Cells in Primary Prostate Cancer Promote Resistance to Hormonal Therapy" [Eur Urol 2022;81(5):446-55].” Eur Urol 83, no. 6 (June 2023): e170–71. https://doi.org/10.1016/j.eururo.2023.03.019.
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  - Wang, Mu-En, Jiaqi Chen, Yi Lu, Alyssa R. Bawcom, Jinjin Wu, Jianhong Ou, John M. Asara, et al. “RB1-deficient prostate tumor growth and metastasis are vulnerable to ferroptosis induction via the E2F/ACSL4 axis.” J Clin Invest 133, no. 10 (May 15, 2023). https://doi.org/10.1172/JCI166647.
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  - Wen, Yu-Ching, Van Thi Ngoc Tram, Wei-Hao Chen, Chien-Hsiu Li, Hsiu-Lien Yeh, Phan Vu Thuy Dung, Kuo-Ching Jiang, et al. “CHRM4/AKT/MYCN upregulates interferon alpha-17 in the tumor microenvironment to promote neuroendocrine differentiation of prostate cancer.” Cell Death Dis 14, no. 5 (May 4, 2023): 304. https://doi.org/10.1038/s41419-023-05836-7.
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  - Butler, William, Lingfan Xu, Yinglu Zhou, Qing Cheng, J Spencer Hauck, Yiping He, Robert Marek, et al. “Oncofetal protein glypican-3 is a biomarker and critical regulator of function for neuroendocrine cells in prostate cancer.” J Pathol 260, no. 1 (May 2023): 43–55. https://doi.org/10.1002/path.6063.
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  - Butler, William, Colin McDowell, Qing Yang, Yiping He, Yue Zhao, J Spencer Hauck, Yinglu Zhou, et al. “Rewiring of the N-Glycome with prostate cancer progression and therapy resistance.” Npj Precis Oncol 7, no. 1 (February 24, 2023): 22. https://doi.org/10.1038/s41698-023-00363-2.
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  - Chou, Jonathan, Emily A. Egusa, Sinan Wang, Michelle L. Badura, Fei Lee, Anil P. Bidkar, Jun Zhu, et al. “Immunotherapeutic Targeting and PET Imaging of DLL3 in Small-Cell Neuroendocrine Prostate Cancer.” Cancer Res 83, no. 2 (January 18, 2023): 301–15. https://doi.org/10.1158/0008-5472.CAN-22-1433.
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  - Zhao, Bing, Jing Wang, Li Chen, Hong Wang, Chao-Zhao Liang, Jiaoti Huang, and Ling-Fan Xu. “The role of glutamine metabolism in castration-resistant prostate cancer.” Asian J Androl 25, no. 2 (2023): 192–97. https://doi.org/10.4103/aja2022105.
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  - Sjöström, Martin, Shuang G. Zhao, Samuel Levy, Meng Zhang, Yuhong Ning, Raunak Shrestha, Arian Lundberg, et al. “The 5-Hydroxymethylcytosine Landscape of Prostate Cancer.” Cancer Res 82, no. 21 (November 2, 2022): 3888–3902. https://doi.org/10.1158/0008-5472.CAN-22-1123.
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  - Cui, Zhifen, Cong Zeng, Furong Huang, Fuwen Yuan, Jingyue Yan, Yue Zhao, Yufan Zhou, et al. “Cas13d knockdown of lung protease Ctsl prevents and treats SARS-CoV-2 infection.” Nat Chem Biol 18, no. 10 (October 2022): 1056–64. https://doi.org/10.1038/s41589-022-01094-4.
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  - Kotamarti, Srinath, Rajan T. Gupta, Bangchen Wang, Denis Séguier, Zoe Michael, Dylan Zhang, Michael R. Abern, Jiaoti Huang, and Thomas J. Polascik. “Reconciling Discordance Between Prostate Biopsy Histology and Magnetic Resonance Imaging Suspicion - Implementation of a Quality Improvement Protocol of Imaging Re-review and Reverse-fusion Target Analysis.” Eur Urol Oncol 5, no. 5 (October 2022): 483–93. https://doi.org/10.1016/j.euo.2022.06.007.
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  - Yang, Lu, Guangping Gao, and Jiaoti Huang. “Letter to the Editor: mRNA Vaccines in Urological Malignancies.” Hum Gene Ther 33, no. 19–20 (October 2022): 1101–2. https://doi.org/10.1089/hum.2022.29218.lya.
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  - Westbrook, Thomas C., Xiangnan Guan, Eva Rodansky, Diana Flores, Chia Jen Liu, Aaron M. Udager, Radhika A. Patel, et al. “Transcriptional profiling of matched patient biopsies clarifies molecular determinants of enzalutamide-induced lineage plasticity.” Nat Commun 13, no. 1 (September 15, 2022): 5345. https://doi.org/10.1038/s41467-022-32701-6.
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  - Arcot, Rohith, Sitharthan Sekar, Srinath Kotamarti, Madison Krischak, Zoe D. Michael, Wen-Chi Foo, Jiaoti Huang, Thomas J. Polascik, and Rajan T. Gupta. “Structured approach to resolving discordance between PI-RADS v2.1 score and targeted prostate biopsy results: an opportunity for quality improvement.” Abdom Radiol (Ny) 47, no. 8 (August 2022): 2917–27. https://doi.org/10.1007/s00261-022-03562-w.
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  - Dov, David, Serge Assaad, Ameer Syedibrahim, Jonathan Bell, Jiaoti Huang, John Madden, Rex Bentley, et al. “A Hybrid Human-Machine Learning Approach for Screening Prostate Biopsies Can Improve Clinical Efficiency Without Compromising Diagnostic Accuracy.” Arch Pathol Lab Med 146, no. 6 (June 1, 2022): 727–34. https://doi.org/10.5858/arpa.2020-0850-OA.
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  - Chen, Zhong, Zhenqing Ye, Raymond E. Soccio, Tomoyoshi Nakadai, William Hankey, Yue Zhao, Furong Huang, et al. “Phosphorylated MED1 links transcription recycling and cancer growth.” Nucleic Acids Res 50, no. 8 (May 6, 2022): 4450–63. https://doi.org/10.1093/nar/gkac246.
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  - Cheng, Qing, William Butler, Yinglu Zhou, Hong Zhang, Lu Tang, Kathryn Perkinson, Xufeng Chen, et al. “Pre-existing Castration-resistant Prostate Cancer-like Cells in Primary Prostate Cancer Promote Resistance to Hormonal Therapy.” Eur Urol 81, no. 5 (May 2022): 446–55. https://doi.org/10.1016/j.eururo.2021.12.039.
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  - Brown, Landon C., Susan Halabi, Jason A. Somarelli, Michael Humeniuk, Yuan Wu, Taofik Oyekunle, Lauren Howard, et al. “A phase 2 trial of avelumab in men with aggressive-variant or neuroendocrine prostate cancer.” Prostate Cancer Prostatic Dis 25, no. 4 (April 2022): 762–69. https://doi.org/10.1038/s41391-022-00524-7.
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  - Wen, Yu-Ching, Wei-Yu Chen, Van Thi Ngoc Tram, Hsiu-Lien Yeh, Wei-Hao Chen, Kuo-Ching Jiang, Wassim Abou-Kheir, Jiaoti Huang, Michael Hsiao, and Yen-Nien Liu. “Pyruvate kinase L/R links metabolism dysfunction to neuroendocrine differentiation of prostate cancer by ZBTB10 deficiency.” Cell Death Dis 13, no. 3 (March 19, 2022): 252. https://doi.org/10.1038/s41419-022-04694-z.
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  - Owens, Jake L., Elena Beketova, Sheng Liu, Qi Shen, Jogendra Singh Pawar, Andrew M. Asberry, Jie Yang, et al. “Targeting Protein Arginine Methyltransferase 5 Suppresses Radiation-induced Neuroendocrine Differentiation and Sensitizes Prostate Cancer Cells to Radiation.” Mol Cancer Ther 21, no. 3 (March 1, 2022): 448–59. https://doi.org/10.1158/1535-7163.MCT-21-0103.
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  - Wen, Yu-Ching, Chien-Liang Liu, Hsiu-Lien Yeh, Wei-Hao Chen, Kuo-Ching Jiang, Van Thi Ngoc Tram, Michael Hsiao, Jiaoti Huang, Wei-Yu Chen, and Yen-Nien Liu. “PCK1 regulates neuroendocrine differentiation in a positive feedback loop of LIF/ZBTB46 signalling in castration-resistant prostate cancer.” Br J Cancer 126, no. 5 (March 2022): 778–90. https://doi.org/10.1038/s41416-021-01631-3.
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  - Qian, Danwen, Hongliang Liu, Lingling Zhao, Sheng Luo, Kyle M. Walsh, Jiaoti Huang, Chuan-Yuan Li, and Qingyi Wei. “A pleiotropic ATM variant (rs1800057 C>G) is associated with risk of multiple cancers.” Carcinogenesis 43, no. 1 (February 11, 2022): 60–66. https://doi.org/10.1093/carcin/bgab092.
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  - Xu, Lingfan, Bing Zhao, William Butler, Huan Xu, Nan Song, Xufeng Chen, J. Spencer Hauck, et al. “Targeting glutamine metabolism network for the treatment of therapy-resistant prostate cancer.” Oncogene 41, no. 8 (February 2022): 1140–54. https://doi.org/10.1038/s41388-021-02155-z.
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  - AACR Pathology Task Force, Jenny. “Pathology: Hub and Integrator of Modern, Multidisciplinary [Precision] Oncology.” Clin Cancer Res 28, no. 2 (January 15, 2022): 265–70. https://doi.org/10.1158/1078-0432.CCR-21-1206.
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  - Osada, Takuya, Erika J. Crosby, Kensuke Kaneko, Joshua C. Snyder, Joshua D. Ginzel, Chaitanya R. Acharya, Xiao-Yi Yang, et al. “HSP90-Specific nIR Probe Identifies Aggressive Prostate Cancers: Translation from Preclinical Models to a Human Phase I Study.” Mol Cancer Ther 21, no. 1 (January 2022): 217–26. https://doi.org/10.1158/1535-7163.MCT-21-0334.
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  - Wen, Yu-Ching, Yen-Nien Liu, Hsiu-Lien Yeh, Wei-Hao Chen, Kuo-Ching Jiang, Shian-Ren Lin, Jiaoti Huang, Michael Hsiao, and Wei-Yu Chen. “TCF7L1 regulates cytokine response and neuroendocrine differentiation of prostate cancer.” Oncogenesis 10, no. 11 (November 20, 2021): 81. https://doi.org/10.1038/s41389-021-00371-6.
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  - Chen, Zhong, William Hankey, Yue Zhao, Jeff Groth, Furong Huang, Hongyan Wang, Alexandre Rosa Campos, Jiaoti Huang, Robert G. Roeder, and Qianben Wang. “Transcription recycling assays identify PAF1 as a driver for RNA Pol II recycling.” Nat Commun 12, no. 1 (November 3, 2021): 6318. https://doi.org/10.1038/s41467-021-26604-1.
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  - Aggarwal, Rahul, Nicholas R. Rydzewski, Li Zhang, Adam Foye, Won Kim, Kyle T. Helzer, Hamza Bakhtiar, et al. “Prognosis Associated With Luminal and Basal Subtypes of Metastatic Prostate Cancer.” Jama Oncol 7, no. 11 (November 1, 2021): 1644–52. https://doi.org/10.1001/jamaoncol.2021.3987.
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  - Cipollari, Stefano, Neema Jamshidi, Liutao Du, Kyunghyun Sung, Danshan Huang, Daniel J. Margolis, Jiaoti Huang, Robert E. Reiter, and Michael D. Kuo. “Tissue clearing techniques for three-dimensional optical imaging of intact human prostate and correlations with multi-parametric MRI.” Prostate 81, no. 9 (June 2021): 521–29. https://doi.org/10.1002/pros.24129.
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  - Xu, Chenxi, Yi-Hsuan Tsai, Phillip M. Galbo, Weida Gong, Aaron J. Storey, Yuemei Xu, Stephanie D. Byrum, et al. “Cistrome analysis of YY1 uncovers a regulatory axis of YY1:BRD2/4-PFKP during tumorigenesis of advanced prostate cancer.” Nucleic Acids Res 49, no. 9 (May 21, 2021): 4971–88. https://doi.org/10.1093/nar/gkab252.
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  - Fine, Samson W., Kiril Trpkov, Mahul B. Amin, Ferran Algaba, Manju Aron, Dilek E. Baydar, Antonio Lopez Beltran, et al. “Practice patterns related to prostate cancer grading: results of a 2019 Genitourinary Pathology Society clinician survey.” Urol Oncol 39, no. 5 (May 2021): 295.e1-295.e8. https://doi.org/10.1016/j.urolonc.2020.08.027.
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  - Epstein, Jonathan I., Mahul B. Amin, Samson W. Fine, Ferran Algaba, Manju Aron, Dilek E. Baydar, Antonio Lopez Beltran, et al. “The 2019 Genitourinary Pathology Society (GUPS) White Paper on Contemporary Grading of Prostate Cancer.” Arch Pathol Lab Med 145, no. 4 (April 1, 2021): 461–93. https://doi.org/10.5858/arpa.2020-0015-RA.
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  - Xu, Lingfan, Yu Yin, Yanjing Li, Xufeng Chen, Yan Chang, Hong Zhang, Juan Liu, et al. “A glutaminase isoform switch drives therapeutic resistance and disease progression of prostate cancer.” Proc Natl Acad Sci U S A 118, no. 13 (March 30, 2021). https://doi.org/10.1073/pnas.2012748118.
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  - Aggarwal, Rahul, Gustavo Rubio Romero, Verena Friedl, Alana Weinstein, Adam Foye, Jiaoti Huang, Felix Feng, Joshua M. Stuart, and Eric J. Small. “Clinical and genomic characterization of Low PSA Secretors: a unique subset of metastatic castration resistant prostate cancer.” Prostate Cancer Prostatic Dis 24, no. 1 (March 2021): 81–87. https://doi.org/10.1038/s41391-020-0228-0.
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  - Butler, William, and Jiaoti Huang. “Neuroendocrine cells of the prostate: Histology, biological functions, and molecular mechanisms.” Precis Clin Med 4, no. 1 (March 2021): 25–34. https://doi.org/10.1093/pcmedi/pbab003.
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  - Ma, Yongjie, Junyi Zha, XiangKun Yang, Qianjin Li, Qingfu Zhang, Amelia Yin, Zanna Beharry, et al. “Long-chain fatty acyl-CoA synthetase 1 promotes prostate cancer progression by elevation of lipogenesis and fatty acid beta-oxidation.” Oncogene 40, no. 10 (March 2021): 1806–20. https://doi.org/10.1038/s41388-021-01667-y.
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  - Kahokehr, Arman A., William R. Boysen, Michael H. Schild, Brent D. Nosé, Jiaoti Huang, Will Eward, and Andrew C. Peterson. “Urinary Pubic Symphysis Fistula Leads to Histopathologic Osteomyelitis in Prostate Cancer Survivors.” Urology 148 (February 2021): 297–301. https://doi.org/10.1016/j.urology.2020.07.038.
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  - Chen, Wei-Yu, Yu-Ching Wen, Shian-Ren Lin, Hsiu-Lien Yeh, Kuo-Ching Jiang, Wei-Hao Chen, Yow-Sien Lin, et al. “Nerve growth factor interacts with CHRM4 and promotes neuroendocrine differentiation of prostate cancer and castration resistance.” Commun Biol 4, no. 1 (January 4, 2021): 22. https://doi.org/10.1038/s42003-020-01549-1.
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  - Buckup, Mark, Meghan A. Rice, En-Chi Hsu, Fernando Garcia-Marques, Shiqin Liu, Merve Aslan, Abel Bermudez, Jiaoti Huang, Sharon J. Pitteri, and Tanya Stoyanova. “Plectin is a regulator of prostate cancer growth and metastasis.” Oncogene 40, no. 3 (January 2021): 663–76. https://doi.org/10.1038/s41388-020-01557-9.
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  - Butler, William, and Jiaoti Huang. “Glycosylation Changes in Prostate Cancer Progression.” Front Oncol 11 (2021): 809170. https://doi.org/10.3389/fonc.2021.809170.
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  - Dong, Bushu, Alex M. Jaeger, Philip F. Hughes, David R. Loiselle, J Spencer Hauck, Yao Fu, Timothy A. Haystead, Jiaoti Huang, and Dennis J. Thiele. “Targeting therapy-resistant prostate cancer via a direct inhibitor of the human heat shock transcription factor 1.” Sci Transl Med 12, no. 574 (December 16, 2020). https://doi.org/10.1126/scitranslmed.abb5647.
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  - Kwon, Daniel H., Li Zhang, David A. Quigley, Adam Foye, William S. Chen, Christopher K. Wong, Felix Y. Feng, et al. “Down-regulation of ADRB2 expression is associated with small cell neuroendocrine prostate cancer and adverse clinical outcomes in castration-resistant prostate cancer.” Urol Oncol 38, no. 12 (December 2020): 931.e9-931.e16. https://doi.org/10.1016/j.urolonc.2020.06.002.
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  - Brown, Landon C., Jason Zhu, Matthew K. Labriola, Yuan Wu, Sachica Cheris, Xin Liu, Kathryn Perkinson, et al. “PD-L1 Assay Concordance in Metastatic Renal Cell Carcinoma and Metastatic Urothelial Carcinoma.” Clin Genitourin Cancer 18, no. 6 (December 2020): 509–13. https://doi.org/10.1016/j.clgc.2020.03.020.
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  - Hu, Yueh-Chiang, Shuyuan Yeh, Shauh-Der Yeh, Erik R. Sampson, Jiaoti Huang, Peng Li, Cheng-Lung Hsu, et al. “Correction: Functional domain and motif analyses of androgen receptor coregulator ARA70 and its differential expression in prostate cancer.” The Journal of Biological Chemistry 295, no. 50 (December 2020): 17382. https://doi.org/10.1074/jbc.aac120.016763.
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  - Morris, D Cody, Derek Y. Chan, Theresa H. Lye, Hong Chen, Mark L. Palmeri, Thomas J. Polascik, Wen-Chi Foo, Jiaoti Huang, Jonathan Mamou, and Kathryn R. Nightingale. “Multiparametric Ultrasound for Targeting Prostate Cancer: Combining ARFI, SWEI, QUS and B-Mode.” Ultrasound Med Biol 46, no. 12 (December 2020): 3426–39. https://doi.org/10.1016/j.ultrasmedbio.2020.08.022.
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  - Beketova, Elena, Shuyi Fang, Jake L. Owens, Sheng Liu, Xufeng Chen, Qingfu Zhang, Andrew M. Asberry, et al. “Protein Arginine Methyltransferase 5 Promotes pICln-Dependent Androgen Receptor Transcription in Castration-Resistant Prostate Cancer.” Cancer Res 80, no. 22 (November 15, 2020): 4904–17. https://doi.org/10.1158/0008-5472.CAN-20-1228.
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  - Lovnicki, Jessica, Yu Gan, Tingting Feng, Yinan Li, Ning Xie, Chia-Hao Ho, Ahn R. Lee, et al. “LIN28B promotes the development of neuroendocrine prostate cancer.” J Clin Invest 130, no. 10 (October 1, 2020): 5338–48. https://doi.org/10.1172/JCI135373.
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  - Lin, Shian-Ren, Yu-Ching Wen, Hsiu-Lien Yeh, Kuo-Ching Jiang, Wei-Hao Chen, Ntlotlang Mokgautsi, Jiaoti Huang, Wei-Yu Chen, and Yen-Nien Liu. “EGFR-upregulated LIFR promotes SUCLG2-dependent castration resistance and neuroendocrine differentiation of prostate cancer.” Oncogene 39, no. 44 (October 2020): 6757–75. https://doi.org/10.1038/s41388-020-01468-9.
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  - Guan, Xiangnan, Duanchen Sun, Eric Lu, Joshua A. Urrutia, Robert Evan Reiter, Matthew Rettig, Christopher P. Evans, et al. “Copy Number Loss of 17q22 Is Associated with Enzalutamide Resistance and Poor Prognosis in Metastatic Castration-Resistant Prostate Cancer.” Clin Cancer Res 26, no. 17 (September 1, 2020): 4616–24. https://doi.org/10.1158/1078-0432.CCR-19-2303.
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  - Hankey, William, Benjamin Sunkel, Fuwen Yuan, Haiyan He, Jennifer M. Thomas-Ahner, Zhong Chen, Steven K. Clinton, Jiaoti Huang, and Qianben Wang. “Prostate Cancer Cell Phenotypes Remain Stable Following PDE5 Inhibition in the Clinically Relevant Range.” Transl Oncol 13, no. 9 (September 2020): 100797. https://doi.org/10.1016/j.tranon.2020.100797.
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  - Acharya, U., A. Adare, C. Aidala, N. N. Ajitanand, Y. Akiba, R. Akimoto, M. Alfred, et al. “Measurement of charged pion double spin asymmetries at midrapidity in longitudinally polarized p+p collisions at s=510 GeV.” Physical Review D 102, no. 3 (August 5, 2020). https://doi.org/10.1103/physrevd.102.032001.
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  - Zhao, Shuang G., William S. Chen, Haolong Li, Adam Foye, Meng Zhang, Martin Sjöström, Rahul Aggarwal, et al. “The DNA methylation landscape of advanced prostate cancer.” Nat Genet 52, no. 8 (August 2020): 778–89. https://doi.org/10.1038/s41588-020-0648-8.
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  - Wang, Jun, Chaoyi Yu, Shuaibin Zhang, Juanying Ye, Hang Dai, Hongkuan Wang, Jiyue Huang, et al. “Cell-type-dependent histone demethylase specificity promotes meiotic chromosome condensation in Arabidopsis.” Nat Plants 6, no. 7 (July 2020): 823–37. https://doi.org/10.1038/s41477-020-0697-0.
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  - Li, Qiuhui, Bigang Liu, Hsueh-Ping Chao, Yibing Ji, Yue Lu, Rashid Mehmood, Collene Jeter, et al. “Author Correction: LRIG1 is a pleiotropic androgen receptor-regulated feedback tumor suppressor in prostate cancer.” Nat Commun 11, no. 1 (June 4, 2020): 2895. https://doi.org/10.1038/s41467-020-16615-9.
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  - Alumkal, Joshi J., Duanchen Sun, Eric Lu, Tomasz M. Beer, George V. Thomas, Emile Latour, Rahul Aggarwal, et al. “Transcriptional profiling identifies an androgen receptor activity-low, stemness program associated with enzalutamide resistance.” Proc Natl Acad Sci U S A 117, no. 22 (June 2, 2020): 12315–23. https://doi.org/10.1073/pnas.1922207117.
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  - Deng, Xuehong, Han Liu, Jiaoti Huang, Liang Cheng, Evan T. Keller, Sarah J. Parsons, and Chang-Deng Hu. “Ionizing radiation induces prostate cancer neuroendocrine differentiation through interplay of CREB and ATF2: implications for disease progression.” Cancer Res 68, no. 23 (December 1, 2008): 9663–70. https://doi.org/10.1158/0008-5472.CAN-08-2229.
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  - Liu, Bo, Hsiao-Man Ivy Yu, Jiaoti Huang, and Wei Hsu. “Co-opted JNK/SAPK signaling in Wnt/beta-catenin-induced tumorigenesis.” Neoplasia 10, no. 9 (September 2008): 1004–13. https://doi.org/10.1593/neo.08548.
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  - Li, Lin, Haodong Xu, Betsy O. Spaulding, Liang Cheng, Rochelle Simon, Jorge L. Yao, P Anthony di Sant’Agnese, Patricia A. Bourne, and Jiaoti Huang. “Expression of RNA-binding protein IMP3 (KOC) in benign urothelium and urothelial tumors.” Hum Pathol 39, no. 8 (August 2008): 1205–11. https://doi.org/10.1016/j.humpath.2007.12.012.
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  - Cai, Yi, Yi-Fen Lee, Gonghui Li, Su Liu, Bo-Ying Bao, Jiaoti Huang, Cheng-Lung Hsu, and Chawnshang Chang. “A new prostate cancer therapeutic approach: combination of androgen ablation with COX-2 inhibitor.” Int J Cancer 123, no. 1 (July 1, 2008): 195–201. https://doi.org/10.1002/ijc.23481.
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  - Gobbo, Stefano, John N. Eble, Jiaoti Huang, David J. Grignon, Mingsheng Wang, Guido Martignoni, Matteo Brunelli, and Liang Cheng. “Schwannoma of the kidney.” Mod Pathol 21, no. 6 (June 2008): 779–83. https://doi.org/10.1038/modpathol.2008.52.
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  - Johnson, Aimee M., Mary J. O’Connell, Hiroshi Miyamoto, Jiaoti Huang, Jorge L. Yao, Edward M. Messing, and Jay E. Reeder. “Androgenic dependence of exophytic tumor growth in a transgenic mouse model of bladder cancer: a role for thrombospondin-1.” Bmc Urol 8 (April 23, 2008): 7. https://doi.org/10.1186/1471-2490-8-7.
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  - Yao, J. L., J. Huang, and P. Anthony di Sant’Agnese. “Small cell carcinoma of the prostate.” Diagnostic Histopathology 14, no. 3 (March 1, 2008): 117–21. https://doi.org/10.1016/j.mpdhp.2008.02.005.
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  - Lei, Jun-Yi, and Jiaoti Huang. “Cytoplasmic staining of TTF-1 in the differential diagnosis of hepatocellular carcinoma.” Expert Opin Med Diagn 2, no. 2 (February 2008): 151–59. https://doi.org/10.1517/17530059.2.2.151.
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  - Ross, Robert W., Tomasz M. Beer, Susanna Jacobus, Glenn J. Bubley, Mary-Ellen Taplin, Christopher W. Ryan, Jiaoti Huang, William K. Oh, and William K. Prostate Cancer Clinical Trials Consortium. “A phase 2 study of carboplatin plus docetaxel in men with metastatic hormone-refractory prostate cancer who are refractory to docetaxel.” Cancer 112, no. 3 (February 1, 2008): 521–26. https://doi.org/10.1002/cncr.23195.
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  - Ross, R. W., T. M. Beer, S. Jacobus, G. T. Bubley, M. -. E. Taplin, C. Ryan, J. Huang, and W. K. Oh. “A Phase II study of carboplatin plus docetaxel in men with metastatic hormone refractory prostate cancer who are refractory to docetaxel.” Cancer 112 (2008): 521–26.
  - Li, Lin, Jorge L. Yao, P Anthony di Sant’Agnese, Patricia A. Bourne, Maria M. Picken, Andrew N. Young, Steven S. Shen, and Jiaoti Huang. “Expression of claudin-7 in benign kidney and kidney tumors.” Int J Clin Exp Pathol 1, no. 1 (January 1, 2008): 57–64.
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  - Simon, Rochelle A., P Anthony di Sant’agnese, Ganesh S. Palapattu, Eric A. Singer, Grace D. Candelario, Jiaoti Huang, and Jorge L. Yao. “Mucinous tubular and spindle cell carcinoma of the kidney with sarcomatoid differentiation.” Int J Clin Exp Pathol 1, no. 2 (January 1, 2008): 180–84.
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  - Wagner, David G., Jorge L. Yao, P Anthony di Sant’Agnese, Liang Cheng, Antonio Lopez-Beltran, Rodolfo Montironi, and Jiaoti Huang. “Soft tissue tumors of the prostate: a review.” Anal Quant Cytol Histol 29, no. 6 (December 2007): 341–50.
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  - Hui, Pei, Hanlin L. Wang, Peiguo Chu, Bin Yang, Jiaoti Huang, Rebecca N. Baergen, Jeffrey Sklar, Ximing J. Yang, and Robert A. Soslow. “Absence of Y chromosome in human placental site trophoblastic tumor.” Mod Pathol 20, no. 10 (October 2007): 1055–60. https://doi.org/10.1038/modpathol.3800941.
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  - Huang, Jiaoti, Chengyu Wu, P Anthony di Sant’Agnese, Jorge L. Yao, Liang Cheng, and Yanqun Na. “Function and molecular mechanisms of neuroendocrine cells in prostate cancer.” Anal Quant Cytol Histol 29, no. 3 (June 2007): 128–38.
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  - Bhatt, Shweta, Jiaoti Huang, and Vikram Dogra. “Littoral cell angioma of the spleen.” Ajr Am J Roentgenol 188, no. 5 (May 2007): 1365–66. https://doi.org/10.2214/AJR.06.1157.
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  - Liang, John J., Zhengxin Wang, Luis Chiriboga, M Alba Greco, Ellen Shapiro, Hongying Huang, Ximing J. Yang, et al. “The expression and function of androgen receptor coactivator p44 and protein arginine methyltransferase 5 in the developing testis and testicular tumors.” J Urol 177, no. 5 (May 2007): 1918–22. https://doi.org/10.1016/j.juro.2007.01.017.
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  - Wu, Chengyu, and Jiaoti Huang. “Phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin pathway is essential for neuroendocrine differentiation of prostate cancer.” J Biol Chem 282, no. 6 (February 9, 2007): 3571–83. https://doi.org/10.1074/jbc.M608487200.
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  - Oh, William K., Miah-Hiang Tay, and Jiaoti Huang. “Is there a role for platinum chemotherapy in the treatment of patients with hormone-refractory prostate cancer?” Cancer 109, no. 3 (February 1, 2007): 477–86. https://doi.org/10.1002/cncr.22439.
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  - Bhatt, S., J. Huang, and V. S. Dogra. “Littoral cell angioma of spleen: Radiologic-pathologic correlation.” Ajr. American Journal of Roentgenology 188, no. 5 (2007): 1365–66.
  - Cheng, L., S. Zhang, M. Wang, D. D. Davidson, M. J. Morton, J. Huang, S. Zheng, T. D. Jones, S. D. Beck, and R. S. Foster. “Molecular Genetic Evidence Supporting the Neoplastic Nature of Stromal Cells in “Fibrosis” After Chemotherapy for Testicular Germ Cell Tumors.” American Journal of Pathology 213 (2007): 65–71.
  - Podder, T. K., J. Sherman, L. Li, J. Joseph, D. R. Rubens, E. M. Messing, J. Huang, and Y. Yu. “Mechanical properties of human prostate tissue in the context of surgical needle insertion.” International Journal for Computer Assisted Radiology and Surgery 2, no. Suppl I (2007): S106–8.
  - Wagner, D. G., J. L. Yao, P. A. di Sant’Agnese, L. Cheng, A. Lopez-Beltran, R. Montironi, and J. Huang. “Soft tissue tumors in the prostate.” Analytical and Quantitative Cytology and Histology / the International Academy of Cytology [And] American Society of Cytology 29 (2007): 341–50.
  - Wu, C., and J. Huang. “PI3 kinase-AKT-mTOR pathway is involved in neuroendocrine differentiation of prostate cancer.” The Journal of Biological Chemistry 282, no. 6 (2007): 3571–83.
  - Wagner, David, Jean Joseph, Jiaoti Huang, and Haodong Xu. “Malakoplakia of the prostate on needle core biopsy: a case report and review of the literature.” Int J Surg Pathol 15, no. 1 (January 2007): 86–89. https://doi.org/10.1177/1066896906295892.
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  - Markhardt, B Keegan, Deborah J. Rubens, Jiaoti Huang, and Vikram S. Dogra. “Sonographic features of biliary hamartomas with histopathologic correlation.” J Ultrasound Med 25, no. 12 (December 2006): 1631–33. https://doi.org/10.7863/jum.2006.25.12.1631.
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  - Zhang, Zhihong, Daniel G. Rosen, Jorge L. Yao, Jiaoti Huang, and Jinsong Liu. “Expression of p14ARF, p15INK4b, p16INK4a, and DCR2 increases during prostate cancer progression.” Mod Pathol 19, no. 10 (October 2006): 1339–43. https://doi.org/10.1038/modpathol.3800655.
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  - Huang, Jiaoti, Jorge L. Yao, P Anthony di Sant’Agnese, Qi Yang, Patricia A. Bourne, and Yanqun Na. “Immunohistochemical characterization of neuroendocrine cells in prostate cancer.” Prostate 66, no. 13 (September 15, 2006): 1399–1406. https://doi.org/10.1002/pros.20434.
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  - Wu, Cheng-yu, Yan-qun Na, Jorge L. Yao, P Anthony di Sant’Agnese, and Jiao-ti Huang. “[Neuroendocrine differentiation in prostate cancer].” Zhonghua Bing Li Xue Za Zhi 35, no. 9 (September 2006): 565–67.
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  - Wu, Chengyu, Li Zhang, Patricia A. Bourne, Jay E. Reeder, P Anthony di Sant’Agnese, Jorge L. Yao, Yanqun Na, and Jiaoti Huang. “Protein tyrosine phosphatase PTP1B is involved in neuroendocrine differentiation of prostate cancer.” Prostate 66, no. 11 (August 1, 2006): 1125–35. https://doi.org/10.1002/pros.20412.
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  - Johnson, Aimee M., David L. Conover, Jiaoti Huang, Edward M. Messing, Ruola Ning, Mary J. O’Connell, M Adrian Rossi, et al. “Early detection and measurement of urothelial tumors in mice.” Urology 67, no. 6 (June 2006): 1309–14. https://doi.org/10.1016/j.urology.2005.12.011.
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  - Yao, Jorge L., Ralph Madeb, Patricia Bourne, Junyi Lei, Ximing Yang, Satish Tickoo, Zhengzhi Liu, et al. “Small cell carcinoma of the prostate: an immunohistochemical study.” Am J Surg Pathol 30, no. 6 (June 2006): 705–12. https://doi.org/10.1097/00000478-200606000-00005.
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  - Lei, Jun-Yi, Patricia A. Bourne, P Anthony diSant’Agnese, and Jiaoti Huang. “Cytoplasmic staining of TTF-1 in the differential diagnosis of hepatocellular carcinoma vs cholangiocarcinoma and metastatic carcinoma of the liver.” Am J Clin Pathol 125, no. 4 (April 2006): 519–25. https://doi.org/10.1309/59TN-EFAL-UL5W-J94M.
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  - Sun, Y., D. Gao, Y. Liu, J. Huang, S. Lessnick, and S. Tanaka. “IGF2 is critical for tumorigenesis by synovial sarcoma oncoprotein SYT-SSX1.” Oncogene 25, no. 7 (February 16, 2006): 1042–52. https://doi.org/10.1038/sj.onc.1209143.
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  - Li, Huixiang, Lurong Zhang, Hong Lou, Ivan Ding, Sunghee Kim, Luping Wang, Jiaoti Huang, P Anthony Di Sant’Agnese, and Jun-Yi Lei. “Overexpression of decoy receptor 3 in precancerous lesions and adenocarcinoma of the esophagus.” Am J Clin Pathol 124, no. 2 (August 2005): 282–87. https://doi.org/10.1309/XK59-4E4B-5WU8-2QR6.
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  - Huang, Jiaoti, Jorge L. Yao, Li Zhang, Patricia A. Bourne, Andrew M. Quinn, P Anthony di Sant’Agnese, and Jay E. Reeder. “Differential expression of interleukin-8 and its receptors in the neuroendocrine and non-neuroendocrine compartments of prostate cancer.” Am J Pathol 166, no. 6 (June 2005): 1807–15. https://doi.org/10.1016/S0002-9440(10)62490-X.
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  - Li, Rongshan, Jing Ni, Patricia A. Bourne, Shuyuan Yeh, Jorge Yao, P Anthony di Sant’Agnese, and Jiaoti Huang. “Cell culture block array for immunocytochemical study of protein expression in cultured cells.” Appl Immunohistochem Mol Morphol 13, no. 1 (March 2005): 85–90. https://doi.org/10.1097/00129039-200503000-00014.
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  - Huang, J., C. Wu, J. L. Yao, and P. A. di Sant’Agnese. “Neuroendocrine differentiation in prostate cancer.” Edited by B. Q. Wu. Proceedings of the 4th Asian Pacific International Academy of Pathology Congress, 2005, 57–61.
  - Li, H., L. Zhang, H. Lou, I. Ding, S. Kim, L. Wang, J. Huang, P. A. Di Sant’Agnese, and J. Y. Lei. “Overexpression of decoy receptor 3 in precancerous lesions and adenocarcinoma of the esophagus.” American Journal of Clinical Pathology 124, no. 2 (January 1, 2005): 282–87. https://doi.org/10.1309/XK594E4B5WU82QR6.
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  - Li, Rongshan, Jorge L. Yao, Patricia A. Bourne, P Anthony di Sant’Agnese, and Jiaoti Huang. “Frequent expression of human carcinoma-associated antigen, a mucin-type glycoprotein, in cells of prostatic carcinoma.” Arch Pathol Lab Med 128, no. 12 (December 2004): 1412–17. https://doi.org/10.5858/2004-128-1412-FEOHCA.
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  - Liang, Songlin, Jorge Yao, Patricia A. Bourne, P Anthony diSant’Agnese, Jiaoti Huang, and Jun-Yi Lei. “Overexpression of human carcinoma-associated antigen in esophageal adenocarcinoma and its precursor lesions.” Am J Clin Pathol 122, no. 5 (November 2004): 747–51. https://doi.org/10.1309/02AP-A6AP-GL43-GCTR.
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  - Hu, Yueh-Chiang, Shuyuan Yeh, Shauh-Der Yeh, Erik R. Sampson, Jiaoti Huang, Peng Li, Cheng-Lung Hsu, et al. “Functional domain and motif analyses of androgen receptor coregulator ARA70 and its differential expression in prostate cancer.” The Journal of Biological Chemistry 279, no. 32 (August 2004): 33438–46. https://doi.org/10.1074/jbc.m401781200.
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  - Patton, Kurt T., Maria S. Tretiakova, Jorge L. Yao, Veronica Papavero, Lei Huo, Brian P. Adley, Guan Wu, et al. “Expression of RON Proto-oncogene in Renal Oncocytoma and Chromophobe Renal Cell Carcinoma.” Am J Surg Pathol 28, no. 8 (August 2004): 1045–50. https://doi.org/10.1097/01.pas.0000128661.58697.7d.
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  - Yao, Jorge L., Patricia A. Bourne, Qi Yang, Junyi Lei, P Anthony di Sant’Agnese, and Jiaoti Huang. “Overexpression of human carcinoma-associated antigen in urothelial carcinoma of the bladder.” Arch Pathol Lab Med 128, no. 7 (July 2004): 785–87. https://doi.org/10.5858/2004-128-785-OOHCAI.
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  - Chen, Terina S., Melanie McNally, William Hulbert, P Anthony Di Sant’Agnese, and Jiaoti Huang. “Renal oncocytosis presenting in childhood: a case report.” Int J Surg Pathol 11, no. 4 (October 2003): 325–29. https://doi.org/10.1177/106689690301100415.
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  - Ni, Jing, Ming Chen, Yu Zhang, Rongshan Li, Jiaoti Huang, and Shuyuan Yeh. “Vitamin E succinate inhibits human prostate cancer cell growth via modulating cell cycle regulatory machinery.” Biochem Biophys Res Commun 300, no. 2 (January 10, 2003): 357–63. https://doi.org/10.1016/s0006-291x(02)02851-6.
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  - Daiss, J., J. Carney, R. Cartun, J. Codington, C. Erdrich, C. Hinchman, J. Huang, J. Mauck, and P. Schnipelsky. “Human Carcinoma Antigen: A Marker Useful for Discriminating between Benign Prostatic Hyperplasia and Prostate Cancer.” Journal of Clinical Ligand Assay 26 (2003): 177–80.
  - Lee, Yi-Fen, Wen-Jye Lin, Jiaoti Huang, Edward M. Messing, Franky L. Chan, George Wilding, and Chawnshang Chang. “Activation of mitogen-activated protein kinase pathway by the antiandrogen hydroxyflutamide in androgen receptor-negative prostate cancer cells.” Cancer Res 62, no. 21 (November 1, 2002): 6039–44.
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  - Huang, Jiaoti, Carmen Behrens, Ignacio I. Wistuba, Adi F. Gazdar, and Jaishree Jagirdar. “Clonality of combined tumors.” Arch Pathol Lab Med 126, no. 4 (April 2002): 437–41. https://doi.org/10.5858/2002-126-0437-COCT.
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  - Liu, Z., J. Huang, Z. Yan, and J. Tan. “Application of flow cytometry in the diagnosis and differential disgnosis of lymphoma and leukemia.” Zhonghua Bing Li Xue Za Zhi Chinese Journal of Pathology 31 (2002): 352–53.
  - Huang, J., C. Behrens, I. I. Wistuba, A. F. Gazdar, and J. Jagirdar. “Clonality of combined tumors: A molecular genetic study.” Archives of Pathology & Laboratory Medicine 126 (2002): 437–41.
  - Huang, J., C. Behrens, I. Wistuba, A. F. Gazdar, and J. Jagirdar. “Molecular analysis of synchronous and metachronous tumors of the lung: impact on management and prognosis.” Ann Diagn Pathol 5, no. 6 (December 2001): 321–29. https://doi.org/10.1053/adpa.2001.29338.
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  - Gu, M., W. Shi, J. Huang, R. R. Barakat, H. T. Thaler, and P. E. Saigo. “Association between initial diagnostic procedure and hysteroscopy and abnormal peritoneal washings in patients with endometrial carcinoma.” Cancer 90, no. 3 (June 25, 2000): 143–47. https://doi.org/10.1002/1097-0142(20000625)90:3<143::aid-cncr2>3.0.co;2-h.
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  - Saric, Muhamed, Robert M. Applebaum, Alfred T. Culliford, Jiaoti Huang, John V. Scholes, and Itzhak Kronzon. “Massive Atrial Septal Lipomatous Hypertrophy.” Echocardiography 16, no. 8 (November 1999): 833–34. https://doi.org/10.1111/j.1540-8175.1999.tb00137.x.
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  - Huang, J., M. Mohammadi, G. A. Rodrigues, and J. Schlessinger. “Reduced activation of RAF-1 and MAP kinase by a fibroblast growth factor receptor mutant deficient in stimulation of phosphatidylinositol hydrolysis.” The Journal of Biological Chemistry 270 (1995): 5065–72.
  - Trachman, J. D., J. Huang, and G. H. Reem. “Activation of human thymocytes induces the phosphorylation of protein tyrosine phosphatase IC.” Comptes Rendus De L’Académie Des Sciences Paris De La Vie/Life Sciences 318 (1995): 367–74.
  - Spivak-Kroizman, T., M. A. Lemmon, I. Dikic, J. E. Ladbury, D. Pinchasi, J. Huang, M. Jaye, G. Crumley, J. Schlessinger, and I. Lax. “Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation.” Cell 79, no. 6 (December 1994): 1015–24. https://doi.org/10.1016/0092-8674(94)90032-9.
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  - Sorokin, A., M. Mohammadi, J. Huang, and J. Schlessinger. “Internalization of fibroblast growth factor receptor is inhibited by a point mutation at tyrosine 766.” J Biol Chem 269, no. 25 (June 24, 1994): 17056–61.
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  - Levy, J. B., P. D. Canoll, O. Silvennoinen, G. Barnea, B. Morse, A. M. Honegger, J. T. Huang, L. A. Cannizzaro, S. H. Park, and T. Druck. “The cloning of a receptor-type protein tyrosine phosphatase expressed in the central nervous system.” J Biol Chem 268, no. 14 (May 15, 1993): 10573–81.
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  - Vogel, W., R. Lammers, J. Huang, and A. Ullrich. “Activation of a phosphotyrosine phosphatase by tyrosine phosphorylation.” Science 259, no. 5101 (March 12, 1993): 1611–14. https://doi.org/10.1126/science.7681217.
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  - Huang, J. T., and R. J. Schneider. “Adenovirus inhibition of cellular protein synthesis involves inactivation of cap-binding protein.” Cell 65, no. 2 (April 19, 1991): 271–80. https://doi.org/10.1016/0092-8674(91)90161-q.
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  - Dolph, P. J., J. T. Huang, and R. J. Schneider. “Translation by the adenovirus tripartite leader: elements which determine independence from cap-binding protein complex.” J Virol 64, no. 6 (June 1990): 2669–77. https://doi.org/10.1128/JVI.64.6.2669-2677.1990.
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  - Huang, J., and R. J. Schneider. “Adenovirus inhibition of cellular protein synthesis is prevented by the drug 2-aminopurine.” Proceedings of the National Academy of Sciences of the United States of America 87, no. 18 (1990): 7115–19.
  - Huang, J., and Z. Tang. “Measurement of estrogen receptor in the nuclei of bone marrow cells of male mice after the administration of estrogen.” Bulletin of the Academy of Military Medical Sciences 2 (1988): 24–26.
- Book Sections
  - Koo, J., C. P. Filson, J. Huang, and A. J. Pantuck. “Collecting Duct Carcinoma and Renal Medullary Carcinoma.” In The Kidney: A Comprehensive Guide to Pathologic Diagnosis and Management, edited by D. E. Hansel, C. J. Kane, G. P. Paner, and S. Chang, 109–23, 2016.
  - Brick, A., J. Niu, J. Huang, and W. K. Oh. “Possibility for Platinum Chemotherapy Treatment for HRPC Patients?” In Drug Management of Prostate Cancer, edited by W. D. Figg, C. H. Chau, and E. J. Small, 153–61. NJ: Humana Press, 2010.
  - Wu, C., G. Chen, Y. Na, D. Xin, J. L. Yao, P. A. di Xant’ Agnese, and J. Huang. “The function of Interleukin-8 in prostate cancer.” In Progress in Chemokine Research, edited by W. P. Links, 149–56. New York: Nova Science Publishers, 2007.
  - Huang, J., J. L. Yao, and P. A. di Sant’Agnese. “Neuroendocrine Differentiation in Prostate Cancer.” In Prostate Cancer: Principles and Practice, edited by R. Kirby, A. W. Partin, M. Feneley, and J. K. Parsons, 143–50. London, UK: Martin Dunitz Ltd (Taylor & Francis Group), 2005.
  - Huang, J., and P. A. di Sant’ Agnese. “Neuroendocrine Differentiation in Prostate Cancer: An Overview.” In Advances in Oncology: The Expanding Role of Octreotide I, edited by S. W. J. Lamberts and L. Dogliotti, 243–62. Bristol, UK: BioScientifica Ltd, 2002.
- Digital Publications
  - Wagner, D. G., and J. Huang. “Small Cell Carcinoma of the Prostate.” eMedicine from WebMD, April 20, 2009.
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- Conference Papers
  - Patierno, Brendon M., Wen-Chi Foo, Tyler Allen, Jason A. Somarelli, Kathryn E. Ware, Santosh Gupta, Sandra Wise, et al. “Characterization of a castrate-resistant prostate cancer xenograft derived from a patient of West African ancestry.” In Prostate Cancer Prostatic Dis, 25:513–23, 2022. https://doi.org/10.1038/s41391-021-00460-y.
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  - Kouchkovsky, Ivan de, Li Zhang, Jiaoti Huang, Kai Trepka, Jonathan Chou, Adam Foye, David Shui, et al. “Clinical and molecular features of low prostate-specific membrane antigen (PSMA) expression in patients (pts) with metastatic castration resistant prostate cancer (mCRPC).” In Journal of Clinical Oncology, 40:167–167. American Society of Clinical Oncology (ASCO), 2022. https://doi.org/10.1200/jco.2022.40.6_suppl.167.
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  - Aggarwal, Rahul Raj, Jacqueline Vuky, David James VanderWeele, Matthew Rettig, Elisabeth I. Heath, Tomasz M. Beer, Jiaoti Huang, et al. “Phase 1a/1b study of FOR46, an antibody drug conjugate (ADC), targeting CD46 in metastatic castration-resistant prostate cancer (mCRPC).” In Journal of Clinical Oncology, Vol. 40, 2022.
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  - Hauck, J Spencer, Xia Gao, William Butler, Lingfan Xu, and Jiaoti Huang. “Targeting a metabolic compensatory mechanism for heat shock factor 1 inhibition in prostate cancer.” In Cancer Research, Vol. 82, 2022.
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  - Logan, Kristen, Jiaoti Huang, Michael Morse, and Chanjuan Shi. “CXCR2 is Highly Expressed in Gastroenteropancreatic Neuroendocrine Tumors.” In Laboratory Investigation, 102:488–89, 2022.
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  - Brown, Landon Carter, Susan Halabi, Michael Sandon Humeniuk, Yuan Wu, Taofik Oyekunle, Jiaoti Huang, Monika Anand, et al. “Efficacy of the PD-L1 inhibitor avelumab in neuroendocrine or aggressive variant prostate cancer: Results from a phase II, single-arm study.” In Journal of Clinical Oncology, 39:89–89. American Society of Clinical Oncology (ASCO), 2021. https://doi.org/10.1200/jco.2021.39.6_suppl.89.
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  - Patierno, Brendon M., Wayne Glover, Wen-Chi Foo, Jason A. Somarelli, Kathryn E. Ware, Lingfan Xu, Yanjing Li, et al. “Abstract A114: Characterization of a metastatic prostate cancer xenograft derived from a patient of African ancestry.” In Cancer Epidemiology, Biomarkers &Amp; Prevention, 29:A114–A114. American Association for Cancer Research (AACR), 2020. https://doi.org/10.1158/1538-7755.disp18-a114.
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  - Kwon, Daniel, Li Zhang, Adam Foye, William S. Chen, Felix Y. Feng, Adina Bailey, Jiaoti Huang, et al. “ADRB2 expression in progressive metastatic castration-resistant prostate cancer.” In Journal of Clinical Oncology, Vol. 38. AMER SOC CLINICAL ONCOLOGY, 2020.
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  - Morris, D. C., D. Y. Chan, H. Chen, M. L. Palmeri, T. J. Polascik, W. C. Foo, J. Huang, J. Mamou, and K. R. Nightingale. “Multiparametric Ultrasound for the Targeting of Prostate Cancer using ARFI, SWEI, B-mode, and QUS.” In Ieee International Ultrasonics Symposium, Ius, 2019-October:880–83, 2019. https://doi.org/10.1109/ULTSYM.2019.8926035.
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  - Gholap, Abhi, Anagha P. Jadhav, Suraj Somwanshi, Gurunath Kamble, Isha Doshi, and Jiaoti Huang. “Abstract 1149: Systems pathology by Optra 30 color multiplex immunofluorescence automated whole slide imaging system integrated with image analysis.” In Cancer Research, 79:1149–1149. American Association for Cancer Research (AACR), 2019. https://doi.org/10.1158/1538-7445.am2019-1149.
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  - Romero, Gustavo Rubio, Alana Weinstein, Verena Friedl, Adam Foye, Denise Playdle, Alexis Sabol, Patricia Li, et al. “Clinical and genomic hallmarks of low PSA secretors in metastatic castration-resistant prostate cancer (mCRPC).” In Journal of Clinical Oncology, Vol. 37. AMER SOC CLINICAL ONCOLOGY, 2019.
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  - Labriola, Matthew, Jason Zhu, Sachica Cheris, Xin Liu, Kathryn Perkinson, Zuowei Su, Shannon McCall, et al. “Concordance between PD-L1 assays for metastatic renal cell carcinoma (mRCC) and metastatic urothelial carcinoma (mUC).” In Journal of Clinical Oncology, 37:e14259–e14259. American Society of Clinical Oncology (ASCO), 2019. https://doi.org/10.1200/jco.2019.37.15_suppl.e14259.
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  - Zhu, Jason, Matthew Labriola, Sachica Cheris, Xin Liu, Kathryn Perkinson, Zuowei Su, Shannon McCall, et al. “Concordance between PD-L1 assays for metastatic renal cell carcinoma (mRCC) and metastatic urothelial carcinoma (mUC).” In Journal of Clinical Oncology, 37:577–577. American Society of Clinical Oncology (ASCO), 2019. https://doi.org/10.1200/jco.2019.37.7_suppl.577.
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  - Liu, Yen-Nien, Wei-Yu Chen, Yuan-Chin Tsai, Hsiu-Lien Yeh, Florent Suau, and Jiaoti Huang. “Abstract A031: Androgen deprivation therapy-induced TGFBI signaling promotes EMT and bone metastasis of prostate cancer.” In Cancer Research, 78:A031–A031. American Association for Cancer Research (AACR), 2018. https://doi.org/10.1158/1538-7445.prca2017-a031.
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  - Hsu, En-chi, Meghan Rice, Rosalie Nolley, Abel Bermudez, Jiaoti Huang, Donna Peehl, Christian Kunder, Sharon Pitteri, James Brooks, and Tanya Stoyanova. “Defining new drivers of castration- resistant prostate cancer.” In Cancer Research, 78:90–90. AMER ASSOC CANCER RESEARCH, 2018.
    Link to Item
  - Park, Jung Wook, Nikolas Balanis, Katherine M. Sheu, Kim Nguyen, John K. Lee, Jiaoti Huang, Thomas Graeber, and Owen N. Witte. “Oncogenic convergence of normal human prostate epithelial cells to a small cell neuroendocrine phenotype.” In Cancer Research, 78:108–108. AMER ASSOC CANCER RESEARCH, 2018.
    Link to Item
  - Smith, Bryan A., Nikolas G. Balanis, Avinash Nanjundiah, Katherine M. Sheu, Qingfu Zhang, Jung Wook Park, Michael Thompson, Jiaoti Huang, Thomas G. Graeber, and Owen N. Witte. “Stem cell-directed pan-cancer analysis reveals a human adult stem cell signature that defines aggressive epithelial cancer subtypes.” In Cancer Research, 78:119–119. AMER ASSOC CANCER RESEARCH, 2018.
    Link to Item
  - Taylor, Clive, Anagha P. Jadhav, Abhi Gholap, Gurunath Kamble, Jiaoti Huang, Allen Gown, Isha Doshi, and David Rimm. “Abstract 1695: A multi-institutional study to evaluate automated scoring of immunohistochemistry slides for assessment of programmed death-ligand 1 (PD-L1) expression in non-small cell lung cancer.” In Cancer Research, 78:1695–1695. American Association for Cancer Research (AACR), 2018. https://doi.org/10.1158/1538-7445.am2018-1695.
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  - Aggarwal, Rahul Raj, Paul Lloyd, Jiaoti Huang, Tomasz M. Beer, Li Zhang, George V. Thomas, Lawrence D. True, et al. “DNA repair mutations and treatment-emergent small cell neuroendocrine prostate cancer (t-SCNC) as hallmarks of distinct subgroups of metastatic castration resistant prostate cancer (mCRPC): Data from the West Coast Prostate Cancer Dream Team.” In Journal of Clinical Oncology, 36:5039–5039. American Society of Clinical Oncology (ASCO), 2018. https://doi.org/10.1200/jco.2018.36.15_suppl.5039.
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  - Aggarwal, Rahul Raj, Li Zhang, Tomasz M. Beer, Jack Youngren, Alise Stromlund, Alexander Bell, Adam Foye, et al. “Serum neuroendocrine (NE) markers and clinical characteristics of treatment-emergent small cell neuroendocrine prostate cancer (t-SCNC) in men with metastatic castration resistant prostate cancer (mCRPC): Data from the West Coast Prostate Cancer Dream Team.” In Journal of Clinical Oncology, 36:278–278. American Society of Clinical Oncology (ASCO), 2018. https://doi.org/10.1200/jco.2018.36.6_suppl.278.
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  - Kim, Won, Eric Jay Small, Rahul Raj Aggarwal, Robert Benjamin Den, Jonathan Lehrer, Li Zhang, Jack Youngren, et al. “Luminal and basal subtyping of metastatic castration-resistant prostate cancer (mCRPC) and its clinical implications.” In Journal of Clinical Oncology, 36:197–197. American Society of Clinical Oncology (ASCO), 2018. https://doi.org/10.1200/jco.2018.36.6_suppl.197.
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  - Huang, Jiaoti, Yu Yin, George Thomas, Lawrence True, Tomasz M. Beer, Martin Gleeve, Owen Witte, et al. “Histologic Spetrum of Metastatic Castration-Resistant Prostate Cancer.” In Laboratory Investigation, 97:231A-231A. NATURE PUBLISHING GROUP, 2017.
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  - Huang, Jiaoti, Yu Yin, George Thomas, Lawrence True, Tomasz M. Beer, Martin Gleeve, Owen Witte, et al. “Histologic Spetrum of Metastatic Castration-Resistant Prostate Cancer.” In Modern Pathology, 30:231A-231A. NATURE PUBLISHING GROUP, 2017.
    Link to Item
  - Small, Eric Jay, Rahul Raj Aggarwal, Jiaoti Huang, Artem Sokolov, Li Zhang, Joshi J. Alumkal, Jack Youngren, et al. “Clinical and genomic characterization of metastatic small cell/neuroendocrine prostate cancer (SCNC) and intermediate atypical prostate cancer (IAC): Results from the SU2C/PCF/AACRWest Coast Prostate Cancer Dream Team (WCDT).” In Journal of Clinical Oncology, 34:5019–5019. American Society of Clinical Oncology (ASCO), 2016. https://doi.org/10.1200/jco.2016.34.15_suppl.5019.
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  - Asvadi, Nazanin, Pooria Khoshnoodi, Hector Alcala, Amin Moshksar, Daniel Margolis, Anthony Sisk, Jiaoti Huang, Robert Reiter, and Steven Raman. “MP21-16 3T MULTI-PARAMETRIC MRI PERFORMANCE IN PROSTATE CANCER DETECTION: PERIPHERAL ZONE TUMORS VS. TRANSITIONAL ZONE.” In Journal of Urology, Vol. 195. Ovid Technologies (Wolters Kluwer Health), 2016. https://doi.org/10.1016/j.juro.2016.02.650.
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  - Natarajan, Shyam, Steven Raman, Alan Priester, James Garritano, Daniel Margolis, Patricia Lieu, Maria Macairan, Jiaoti Huang, Warren Grundfest, and Leonard Marks. “MP18-11 MR-GUIDED FOCAL LASER ABLATION OF INTERMEDIATE RISK PROSTATE CANCER: PHASE I TRIAL.” In Journal of Urology, Vol. 195. Ovid Technologies (Wolters Kluwer Health), 2016. https://doi.org/10.1016/j.juro.2016.02.2712.
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  - Margolis, Daniel, Nelly Tan, Shyam Natarajan, Karim Chamie, David Finley, Robert Evan Reiter, Jiaoti Huang, and Steven Raman. “Value of prostate MRI in determining appropriate candidates for active surveillance.” In Journal of Clinical Oncology, 30:109–109. American Society of Clinical Oncology (ASCO), 2012. https://doi.org/10.1200/jco.2012.30.5_suppl.109.
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  - Samaratunga, H., R. Montrironi, L. True, J. I. Epstein, D. F. Griffiths, P. A. Humphrey, T. van der Kwast, et al. “Working group 1: specimen handling.” In Modern Pathology, 6–15. Nature Publishing Group, 2011.
  - Samaratunga, H., R. Montrironi, L. True, J. I. Epstein, D. F. Griffiths, P. A. Humphrey, T. van der Kwast, et al. “Working group 1: specimen handling.” In Modern Pathology, 6–15. Nature Publishing Group, 2011.
- Preprints
  - Butler, William, Colin McDowell, Yiping He, Qing Yang, Spencer Hauck, Yinglu Zhou, Andrew Armstrong, Daniel George, Richard Drake, and Jiaoti Huang. “Rewiring of the N-Glycome with Prostate Cancer Progression and Therapy Resistance.” Research Square Platform LLC, July 20, 2022. https://doi.org/10.21203/rs.3.rs-1831833/v1.
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Teaching & Mentoring
Recent Courses
- PATHOL 293: Research Independent Study 2023
- PATHOL 793: Research Independent Study 2023
- PATHOL 293: Research Independent Study 2022
- PATHOL 793: Research Independent Study 2022
- PHARM 493: Research Independent Study 2022
- PATHOL 293: Research Independent Study 2021
- PATHOL 793: Research Independent Study 2021

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