Jillian Hurst
Assistant Professor in Pediatrics
Children's Health & Discovery Initiative:
The prenatal period, infancy, childhood, and adolescence, represent critical time periods of human development that include more developmental milestones than any other period of the lifespan. Conditions during these developmental windows – including biological, social, economic, health, and environmental factors – have a profound impact on lifelong health. The Children’s Health and Discovery Initiative (CHDI) was founded on the hypothesis that interventions early in life will improve population health across the lifespan. To this end, the overarching goal of the CHDI is to create a robust coalition of multidisciplinary investigators and a pipeline of infrastructure, data, and research projects focused on developing innovative approaches to identifying and modulating early life factors that impact lifelong health and well-being.
Intersections of the upper respiratory microbiome, environmental exposures, and childhood respiratory infections
Early life exposure to and colonization with microbes has a profound influence on the education of the immune system and susceptibility to viral and bacterial infections later in life. My research is focused on the influence of the upper respiratory microbiome on the development of recurrent respiratory infections, including acute otitis media (AOM), the leading cause of antibiotic prescriptions and healthcare consultations among children. Importantly, some children develop recurrent infections that are thought to be linked to dysbiosis of the nasopharyngeal microbiome. My overarching goals are to identify alterations in the upper respiratory microbiome associated with AOM and to elucidate host factors and exposures that predispose some children to the development of recurrent AOM episodes.
Current Appointments & Affiliations
- Assistant Professor in Pediatrics, Pediatrics, Children's Health Discovery Institute, Pediatrics 2020
Contact Information
- Chesterfield 701 W Main Street, Durham, NC 27710
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jillian.hurst@duke.edu
(919) 668-8776
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Children's Health & Discovery Initiative
- Background
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Education, Training, & Certifications
- Ph.D., University of Georgia 2009
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Previous Appointments & Affiliations
- Adjunct Assistant Professor in the Department of Pediatrics, Pediatrics, Children's Health Discovery Institute, Pediatrics 2019 - 2020
- Recognition
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In the News
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SEP 26, 2022 School of Medicine -
JUL 16, 2021 Duke Health News
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- Research
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Selected Grants
- Impact of Early-life Exposure to Semi-Volatile Organic Compounds (SVOCs) on Neonatal and Early Childhood Immune Function awarded by National Institutes of Health 2022 - 2027
- Early life B cell responses and inflammation following SARS-CoV-2 infection awarded by National Institutes of Health 2021 - 2026
- Insights and Interventions for Infant Diet via DNA metabarcoding awarded by Gerber Foundation 2023 - 2025
- Maternal Predictors of Early Childhood Bacterial Colonization or Invasive Infection awarded by Bristol-Myers Squibb Foundation 2022 - 2024
- Avenues for Prevention and Early Intervention to Address Child Maltreatment awarded by Duke Endowment 2022 - 2024
- Early life B cell responses and inflammation following SARS-CoV-2 infection awarded by Weill Cornell Medicine 2022 - 2023
- HOPE 1000 Sub-study awarded by Social & Scientific Systems, Inc. 2022 - 2023
- Using simulation modeling and real-world data to monitor the effectiveness of the COVID-19 vaccine awarded by Food and Drug Administration 2021 - 2023
- Immune Correlates and Mechanisms of Perinatal Cytomegalovirus Infection and Later lLife ALL Development awarded by National Institutes of Health 2019 - 2022
- Gene expression profiling of children with SARS-CoV-2 infection or exposure awarded by Merck & Co., Inc. 2021 - 2022
- Early Identification and Prevention of Child Maltreatment: Cross-Agency Processes and Outcomes awarded by Duke Endowment 2019 - 2022
- Using electronic health records to identify and assess adverse events for biologics therapies: developing and validating methodological approaches awarded by Food and Drug Administration 2020 - 2022
- A County-level spatiotemporal multi-dimensional database to define risk modifiers of environmentally triggered severe asthma exacerbations in children awarded by National Institutes of Health 2019 - 2021
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Fellowships, Supported Research, & Other Grants
- Ruth L. Kirschstein National Research Service Award awarded by NIGMS 2010 - 2012
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External Relationships
- University of Arkansas
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Hurst, Jillian H., Amanda Brucker, Congwen Zhao, Hannah Driscoll, Haley P. Hostetler, Michael Phillips, Bari Rosenberg, et al. “Use of Structured Electronic Health Records Data Elements for the Development of Computable Phenotypes to Identify Potential Adverse Events Associated with Intravenous Immunoglobulin Infusion.” Drug Saf 46, no. 3 (March 2023): 309–18. https://doi.org/10.1007/s40264-023-01276-6.Full Text Link to Item
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Gulrajani, Natalie B., Samuel Montes, Daniel McGough, Courtney E. Wimberly, Ameera Khattab, Eleanor C. Semmes, Lisa Towry, et al. “Assisted reproductive technology and association with childhood cancer subtypes.” Cancer Med 12, no. 3 (February 2023): 3410–18. https://doi.org/10.1002/cam4.5114.Full Text Link to Item
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Liu, Yuerong, Megan Shepherd-Banigan, Kelly E. Evans, Laura Stilwell, Lindsay Terrell, Jillian H. Hurst, and Elizabeth J. Gifford. “Do children evaluated for maltreatment have higher subsequent emergency department and inpatient care utilization compared to a general pediatric sample?” Child Abuse Negl 134 (December 2022): 105938. https://doi.org/10.1016/j.chiabu.2022.105938.Full Text Link to Item
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Golonka, Megan, Yuerong Liu, Rosie Rohrs, Jennifer Copeland, Jessalyn Byrd, Laura Stilwell, Carter Crew, et al. “What Do Child Abuse and Neglect Medical Evaluation Consultation Notes Tell Researchers and Clinicians?” Child Maltreat, October 20, 2022, 10775595221134536. https://doi.org/10.1177/10775595221134537.Full Text Link to Item
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Khaire, Archita S., Courtney E. Wimberly, Eleanor C. Semmes, Jillian H. Hurst, and Kyle M. Walsh. “An integrated genome and phenome-wide association study approach to understanding Alzheimer's disease predisposition.” Neurobiol Aging 118 (October 2022): 117–23. https://doi.org/10.1016/j.neurobiolaging.2022.05.011.Full Text Link to Item
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Hurst, Jillian H., Alexander W. McCumber, Jhoanna N. Aquino, Javier Rodriguez, Sarah M. Heston, Debra J. Lugo, Alexandre T. Rotta, et al. “Age-Related Changes in the Nasopharyngeal Microbiome Are Associated With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection and Symptoms Among Children, Adolescents, and Young Adults.” Clin Infect Dis 75, no. 1 (August 24, 2022): e928–37. https://doi.org/10.1093/cid/ciac184.Full Text Open Access Copy Link to Item
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Semmes, Eleanor C., Itzayana G. Miller, Courtney E. Wimberly, Caroline T. Phan, Jennifer A. Jenks, Melissa J. Harnois, Stella J. Berendam, et al. “Maternal Fc-mediated non-neutralizing antibody responses correlate with protection against congenital human cytomegalovirus infection.” J Clin Invest 132, no. 16 (August 15, 2022). https://doi.org/10.1172/JCI156827.Full Text Open Access Copy Link to Item
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Uffman, Emilie A., Shuk Hang Li, Jui-Lin Chen, Noel Allen, Sefelani Boiditswe, Genevieve G. Fouda, Jillian H. Hurst, et al. “Kinetics of pneumococcal antibodies among HIV-exposed, uninfected infants in Botswana.” Vaccine 40, no. 33 (August 5, 2022): 4764–71. https://doi.org/10.1016/j.vaccine.2022.06.059.Full Text Link to Item
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Rao, Saahithi, Jillian H. Hurst, Congwen Zhao, Benjamin A. Goldstein, Laine Thomas, Jason E. Lang, and Matthew S. Kelly. “Asthma and the Risk of SARS-CoV-2 Infection Among Children and Adolescents.” Pediatrics 149, no. 6 (June 1, 2022). https://doi.org/10.1542/peds.2021-056164.Full Text Link to Item
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Sabharwal, Paul, Jillian H. Hurst, Rohit Tejwani, Kevin T. Hobbs, Jonathan C. Routh, and Benjamin A. Goldstein. “Correction to: Combining adult with pediatric patient data to develop a clinical decision support tool intended for children: leveraging machine learning to model heterogeneity.” Bmc Med Inform Decis Mak 22, no. 1 (May 12, 2022): 128. https://doi.org/10.1186/s12911-022-01846-1.Full Text Link to Item
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Hurst, Jillian H., Congwen Zhao, Haley P. Hostetler, Mohsen Ghiasi Gorveh, Jason E. Lang, and Benjamin A. Goldstein. “Environmental and clinical data utility in pediatric asthma exacerbation risk prediction models.” Bmc Med Inform Decis Mak 22, no. 1 (April 22, 2022): 108. https://doi.org/10.1186/s12911-022-01847-0.Full Text Link to Item
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Semmes, Eleanor C., Shuk Hang Li, Jillian H. Hurst, Zidanyue Yang, Donna Niedzwiecki, Genevieve G. Fouda, Joanne Kurtzberg, Kyle M. Walsh, and Sallie R. Permar. “Congenital Human Cytomegalovirus Infection Is Associated With Decreased Transplacental IgG Transfer Efficiency Due to Maternal Hypergammaglobulinemia.” Clin Infect Dis 74, no. 7 (April 9, 2022): 1131–40. https://doi.org/10.1093/cid/ciab627.Full Text Open Access Copy Link to Item
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Sabharwal, Paul, Jillian H. Hurst, Rohit Tejwani, Kevin T. Hobbs, Jonathan C. Routh, and Benjamin A. Goldstein. “Combining adult with pediatric patient data to develop a clinical decision support tool intended for children: leveraging machine learning to model heterogeneity.” Bmc Med Inform Decis Mak 22, no. 1 (March 29, 2022): 84. https://doi.org/10.1186/s12911-022-01827-4.Full Text Link to Item
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Kelly, Matthew S., Catherine Plunkett, Yahe Yu, Jhoanna N. Aquino, Sweta M. Patel, Jillian H. Hurst, Rebecca R. Young, et al. “Non-diphtheriae Corynebacterium species are associated with decreased risk of pneumococcal colonization during infancy.” Isme J 16, no. 3 (March 2022): 655–65. https://doi.org/10.1038/s41396-021-01108-4.Full Text Link to Item
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Stolte, Allison, M Giovanna Merli, Jillian H. Hurst, Yaxing Liu, Charles T. Wood, and Benjamin A. Goldstein. “Using Electronic Health Records to understand the population of local children captured in a large health system in Durham County, NC, USA, and implications for population health research.” Soc Sci Med 296 (March 2022): 114759. https://doi.org/10.1016/j.socscimed.2022.114759.Full Text Link to Item
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Hurst, Jillian H., Sarah M. Heston, Hailey N. Chambers, Hannah M. Cunningham, Meghan J. Price, Lilianna Suarez, Carter G. Crew, et al. “Severe Acute Respiratory Syndrome Coronavirus 2 Infections Among Children in the Biospecimens from Respiratory Virus-Exposed Kids (BRAVE Kids) Study.” Clin Infect Dis 73, no. 9 (November 2, 2021): e2875–82. https://doi.org/10.1093/cid/ciaa1693.Full Text Open Access Copy Link to Item
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Hurst, Jillian H., Congwen Zhao, Nicholas S. Fitzpatrick, Benjamin A. Goldstein, and Jason E. Lang. “Reduced pediatric urgent asthma utilization and exacerbations during the COVID-19 pandemic.” Pediatr Pulmonol 56, no. 10 (October 2021): 3166–73. https://doi.org/10.1002/ppul.25578.Full Text Link to Item
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Garrido, Carolina, Jillian H. Hurst, Cynthia G. Lorang, Jhoanna N. Aquino, Javier Rodriguez, Trevor S. Pfeiffer, Tulika Singh, et al. “Asymptomatic or mild symptomatic SARS-CoV-2 infection elicits durable neutralizing antibody responses in children and adolescents.” Jci Insight 6, no. 17 (September 8, 2021). https://doi.org/10.1172/jci.insight.150909.Full Text Link to Item
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Garrido, Carolina, Jillian H. Hurst, Cynthia G. Lorang, Jhoanna N. Aquino, Javier Rodriguez, Trevor S. Pfeiffer, Tulika Singh, et al. “Asymptomatic or mild symptomatic SARS-CoV-2 infection elicits durable neutralizing antibody responses in children and adolescents.” Medrxiv, April 20, 2021. https://doi.org/10.1101/2021.04.17.21255663.Full Text Link to Item
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Gulrajani, Natalie, Samuel Montes, Dan McGough, Courtney Wimberly, Ameera Khattab, Eleanor Semmes, Lisa Towry, et al. “Assisted reproductive technology and association with childhood cancer subtypes,” 2021. https://doi.org/10.1101/2021.04.26.21256117.Full Text
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Hurst, Jillian, Congwen Zhao, Nicholas Fitzpatrick, Benjamin Goldstein, and Jason Lang. “Reduced Pediatric Urgent Asthma Utilization and Exacerbations During the COVID-19 Pandemic,” 2021. https://doi.org/10.1101/2021.04.28.21256263.Full Text
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Semmes, Eleanor, Itzayana Miller, Jennifer Jenks, Courtney Wimberly, Stella Berendam, Melissa Harnois, Helen Webster, et al. “Maternal Fc-mediated non-neutralizing antibody responses correlate with protection against congenital human cytomegalovirus infection,” 2021. https://doi.org/10.1101/2021.12.05.21267312.Full Text Open Access Copy
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Lang, Jason E., Monica Tang, Congwen Zhao, Jillian Hurst, Angie Wu, and Benjamin A. Goldstein. “Well-Child Care Attendance and Risk of Asthma Exacerbations.” Pediatrics 146, no. 6 (December 2020). https://doi.org/10.1542/peds.2020-1023.Full Text Link to Item
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Singh, Tulika, Sarah M. Heston, Stephanie N. Langel, Maria Blasi, Jillian H. Hurst, Genevieve G. Fouda, Matthew S. Kelly, and Sallie R. Permar. “Lessons From COVID-19 in Children: Key Hypotheses to Guide Preventative and Therapeutic Strategies.” Clin Infect Dis 71, no. 8 (November 5, 2020): 2006–13. https://doi.org/10.1093/cid/ciaa547.Full Text Link to Item
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Le, Elliot, Peter Shrader, Hayden Bosworth, Jillian Hurst, Benjamin Goldstein, Amelia Drake, Jeyhan Wood, et al. “Provision and Utilization of Team- and Community-Based Operative Care for Patients With Cleft Lip/Palate in North Carolina.” Cleft Palate Craniofac J 57, no. 11 (November 2020): 1298–1307. https://doi.org/10.1177/1055665620946565.Full Text Link to Item
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Semmes, Eleanor C., Erica Shen, Jennifer L. Cohen, Chenan Zhang, Qingyi Wei, Jillian H. Hurst, and Kyle M. Walsh. “Genetic variation associated with childhood and adult stature and risk of MYCN-amplified neuroblastoma.” Cancer Med 9, no. 21 (November 2020): 8216–25. https://doi.org/10.1002/cam4.3458.Full Text Open Access Copy Link to Item
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Tang, Monica, Benjamin A. Goldstein, Jingye He, Jillian H. Hurst, and Jason E. Lang. “Performance of a computable phenotype for pediatric asthma using the problem list.” Ann Allergy Asthma Immunol 125, no. 5 (November 2020): 611-613.e1. https://doi.org/10.1016/j.anai.2020.07.009.Full Text Link to Item
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He, Jingyi, Mohsen Ghiasi Ghorveh, Jillian H. Hurst, Monica Tang, Brooke Alhanti, Jason E. Lang, and Benjamin A. Goldstein. “Evaluation of associations between asthma exacerbations and distance to roadways using geocoded electronic health records data.” Bmc Public Health 20, no. 1 (October 29, 2020): 1626. https://doi.org/10.1186/s12889-020-09731-0.Full Text Link to Item
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Semmes, Eleanor C., Jillian H. Hurst, Kyle M. Walsh, and Sallie R. Permar. “Cytomegalovirus as an immunomodulator across the lifespan.” Curr Opin Virol 44 (October 2020): 112–20. https://doi.org/10.1016/j.coviro.2020.07.013.Full Text Link to Item
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Hurst, Jillian H., Sarah M. Heston, Hailey N. Chambers, Hannah M. Cunningham, Meghan J. Price, Liliana Suarez, Carter G. Crew, et al. “SARS-CoV-2 Infections Among Children in the Biospecimens from Respiratory Virus-Exposed Kids (BRAVE Kids) Study.” Medrxiv, September 1, 2020. https://doi.org/10.1101/2020.08.18.20166835.Full Text Open Access Copy Link to Item
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Semmes, Eleanor C., Jayaram Vijayakrishnan, Chenan Zhang, Jillian H. Hurst, Richard S. Houlston, and Kyle M. Walsh. “Leveraging Genome and Phenome-Wide Association Studies to Investigate Genetic Risk of Acute Lymphoblastic Leukemia.” Cancer Epidemiol Biomarkers Prev 29, no. 8 (August 2020): 1606–14. https://doi.org/10.1158/1055-9965.EPI-20-0113.Full Text Link to Item
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Hurst, Jillian H., Yaxing Liu, Pamela J. Maxson, Sallie R. Permar, L Ebony Boulware, and Benjamin A. Goldstein. “Development of an electronic health records datamart to support clinical and population health research.” J Clin Transl Sci 5, no. 1 (June 23, 2020): e13. https://doi.org/10.1017/cts.2020.499.Full Text Link to Item
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Zhang, Chenan, Helen M. Hansen, Eleanor C. Semmes, Julio Gonzalez-Maya, Libby Morimoto, Qingyi Wei, William C. Eward, et al. “Common genetic variation and risk of osteosarcoma in a multi-ethnic pediatric and adolescent population.” Bone 130 (January 2020): 115070. https://doi.org/10.1016/j.bone.2019.115070.Full Text Link to Item
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Rangarajan, Nambirajan, Claire L. Gordy, Lauren Askew, Samantha M. Bevill, Timothy C. Elston, Beverly Errede, Jillian H. Hurst, et al. “Systematic analysis of F-box proteins reveals a new branch of the yeast mating pathway.” J Biol Chem 294, no. 40 (October 4, 2019): 14717–31. https://doi.org/10.1074/jbc.RA119.010063.Full Text Open Access Copy Link to Item
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Hurst, Jillian H., Katherine J. Barrett, Matthew S. Kelly, Betty B. Staples, Kathleen A. McGann, Coleen K. Cunningham, Ann M. Reed, Rasheed A. Gbadegesin, and Sallie R. Permar. “Cultivating Research Skills During Clinical Training to Promote Pediatric-Scientist Development.” Pediatrics 144, no. 2 (August 2019). https://doi.org/10.1542/peds.2019-0745.Full Text Open Access Copy Link to Item
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Hurst, Jillian H. “William Kaelin, Peter Ratcliffe, and Gregg Semenza receive the 2016 Albert Lasker Basic Medical Research Award.” J Clin Invest 126, no. 10 (October 3, 2016): 3628–38. https://doi.org/10.1172/JCI90055.Full Text Link to Item
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Hurst, Jillian H. “Cancer immunotherapy innovator James Allison receives the 2015 Lasker~DeBakey Clinical Medical Research Award.” J Clin Invest 125, no. 10 (October 1, 2015): 3732–36. https://doi.org/10.1172/JCI84236.Full Text Link to Item
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Hurst, Jillian H. “Pioneering geneticist Mary-Claire King receives the 2014 Lasker~Koshland Special Achievement Award in Medical Science.” J Clin Invest 124, no. 10 (October 2014): 4148–51. https://doi.org/10.1172/JCI78507.Full Text Link to Item
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Hurst, Jillian H. “Richard Scheller and Thomas Südhof receive the 2013 Albert Lasker Basic Medical Research Award.” J Clin Invest 123, no. 10 (October 2013): 4095–4101. https://doi.org/10.1172/JCI72681.Full Text Link to Item
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Hurst, Jillian H., and Henrik G. Dohlman. “Dynamic ubiquitination of the mitogen-activated protein kinase kinase (MAPKK) Ste7 determines mitogen-activated protein kinase (MAPK) specificity.” J Biol Chem 288, no. 26 (June 28, 2013): 18660–71. https://doi.org/10.1074/jbc.M113.475707.Full Text Link to Item
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Hurst, Jillian. “A modern Cosmas and Damian: Sir Roy Calne and Thomas Starzl receive the 2012 Lasker~Debakey Clinical Medical Research Award.” J Clin Invest 122, no. 10 (October 2012): 3378–82. https://doi.org/10.1172/jci66465.Full Text Link to Item
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Hooks, Shelley B., Phillip Callihan, Molly K. Altman, Jillian H. Hurst, Mourad W. Ali, and Mandi M. Murph. “Regulators of G-Protein signaling RGS10 and RGS17 regulate chemoresistance in ovarian cancer cells.” Mol Cancer 9 (November 2, 2010): 289. https://doi.org/10.1186/1476-4598-9-289.Full Text Link to Item
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Hurst, Jillian H., and Shelley B. Hooks. “Regulator of G-protein signaling (RGS) proteins in cancer biology.” Biochem Pharmacol 78, no. 10 (November 15, 2009): 1289–97. https://doi.org/10.1016/j.bcp.2009.06.028.Full Text Link to Item
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Hurst, Jillian H., Nisha Mendpara, and Shelley B. Hooks. “Regulator of G-protein signalling expression and function in ovarian cancer cell lines.” Cell Mol Biol Lett 14, no. 1 (2009): 153–74. https://doi.org/10.2478/s11658-008-0040-7.Full Text Link to Item
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Hurst, Jillian H., and Shelley B. Hooks. “Lysophosphatidic acid stimulates cell growth by different mechanisms in SKOV-3 and Caov-3 ovarian cancer cells: distinct roles for Gi- and Rho-dependent pathways.” Pharmacology 83, no. 6 (2009): 333–47. https://doi.org/10.1159/000217582.Full Text Link to Item
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Hurst, Jillian H., Jennifer Mumaw, David W. Machacek, Carla Sturkie, Phillip Callihan, Steve L. Stice, and Shelley B. Hooks. “Human neural progenitors express functional lysophospholipid receptors that regulate cell growth and morphology.” Bmc Neurosci 9 (December 11, 2008): 118. https://doi.org/10.1186/1471-2202-9-118.Full Text Link to Item
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Hurst, Jillian H., Paul A. Henkel, April L. Brown, and Shelley B. Hooks. “Endogenous RGS proteins attenuate Galpha(i)-mediated lysophosphatidic acid signaling pathways in ovarian cancer cells.” Cell Signal 20, no. 2 (February 2008): 381–89. https://doi.org/10.1016/j.cellsig.2007.10.026.Full Text Link to Item
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Conference Papers
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Tang, Monica, Anusha Vadlamudi, Matthew McCulloch, Nicole Koutlas, Olga Hardin, Benjamin Goldstein, Jillian Hurst, and Jason Lang. “Performance of an electronic health record definition for pediatric asthma.” In Journal of Allergy and Clinical Immunology, 145:AB213–AB213. MOSBY-ELSEVIER, 2020.Link to Item
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Preprints
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Semmes, Eleanor C., Itzayana G. Miller, Nicole Rodgers, Caroline T. Phan, Jillian H. Hurst, Kyle M. Walsh, Richard J. Stanton, Justin Pollara, and Sallie R. Permar. “ADCC-activating antibodies correlate with protection against congenital human cytomegalovirus infection.,” March 17, 2023. https://doi.org/10.1101/2023.03.15.23287332.Full Text Link to Item
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Rao, Saahithi, Jillian H. Hurst, Congwen Zhao, Benjamin A. Goldstein, Laine Thomas, Jason E. Lang, and Matthew S. Kelly. “Asthma and the Risk of SARS-CoV-2 Infection Among Children and Adolescents.” Cold Spring Harbor Laboratory, July 22, 2021. https://doi.org/10.1101/2021.07.20.21260871.Full Text
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- Teaching & Mentoring
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Recent Courses
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