Jiyong Hong | Scholars@Duke

Jiyong Hong
Professor of Chemistry

Research in the Hong group focuses on using chemical tools, in particular small molecules, to understand the signaling pathways in biology. We synthesize biologically interesting natural products and screen small molecule libraries to identify modulators of biological processes. Then, we explore their modes of action in order to investigate intracellular signaling pathways and identify novel targets for drug design. In addition, we design and develop unique and efficient synthetic strategies that will allow rapid access to molecular complexity and structural diversity. Through multidisciplinary approaches, including organic synthesis, molecular biology, and cell biology, the cellular components and molecular events that embody cancer, immune response, and GPCR signaling have systematically been explored. Compounds employed in these studies could also advance the development of novel therapeutics for the treatment of human diseases.

Synthesis of Natural Products and Study of Mode of Action: We synthesize biologically interesting natural products and explore the modes of action in order to investigate intracellular signaling pathways and identify novel targets for drug design. Completed target molecules include largazole (a marine natural product with HDAC inhibitory activity), brasilibactin A (a cytotoxic siderophore), manassantins A and B (natural products with anti-HIF-1 activity), and subglutinols A and B (natural products with immunosuppressive activity).
Development of Novel Synthetic Methodology: We design and develop unique and efficient synthetic strategies which will allow rapid access to molecular complexity and structural diversity. A specific area of interest includes the development of novel methods for the stereoselective synthesis of substituted tetrahydrofurans and tetrahydropyrans.
Screen of Small Molecule Libraries for Identification of Small Molecule Modulators of Biological Processes: With the advent of combinatorial chemistry and other synthetic technologies, it is feasible to prepare large collections of synthetic organic molecules. These libraries are useful in providing molecules that can be used to probe relevant biological pathways. We are interested in identification of modulators of biological processes, including drug abuse and neurodegenerative diseases.

Through multidisciplinary approaches, the cellular components and molecular events that embody cancer, immune response, and neurodegenerative diseases are systematically explored. Compounds employed in these studies could also advance the development of novel therapeutics for the treatment of human diseases.

Current Appointments & Affiliations

Professor of Chemistry, Chemistry, Trinity College of Arts & Sciences 2017
Associate Professor of Pharmacology and Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2013
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2005

Contact Information

3220 French Science Center, 124 Science Drive, Durham, NC 27708
Box 90346, Durham, NC 27708-0347
jiyong.hong@duke.edu (919) 660-1545
Hong Research Group

Background
Education, Training, & Certifications
- Ph.D., The Scripps Research Institute 2001
- M.S., Seoul National University 1995
- B.S., Seoul National University 1993
Duke Appointment History
- Associate Professor of Chemistry, Chemistry, Trinity College of Arts & Sciences 2011 - 2017
- Director of Graduate Studies in the Department of Chemistry, Chemistry, Trinity College of Arts & Sciences 2013 - 2016
- Assistant Professor of Chemistry, Chemistry, Trinity College of Arts & Sciences 2005 - 2011
Research
Selected Grants
- Discovery and validation of broadly effective LpxH inhibitors as novel therapeutics against multi-drug resistant Gram-negative pathogens awarded by National Institutes of Health 2019 - 2023
- Structural and Mechanistic Characterization of MraY Catalysis and Inhibition awarded by National Institutes of Health 2017 - 2020
- Biosynthesis of peptidyl nucleoside antifungal antibiotics awarded by National Institutes of Health 2015 - 2020
- Pharmacological Sciences Training Program awarded by National Institutes of Health 1975 - 2020
- GAANN - Department of Chemistry awarded by Department of Education 2015 - 2019
- Thermo Lumos Tribrid High-Resolution Accurate-Mass Tandem Mass Spectrometer awarded by National Institutes of Health 2018 - 2019
- Discovery and validation of broadly effective LpxH inhibitors as novel therapeutics against multi-drug resistant Gram-negative pathogens awarded by National Institutes of Health 2018 - 2019
- Study of Subglutinol A as a Potential Immunomodulatory Agent awarded by National Institutes of Health 2016 - 2018
- Human Stringent Response as Novel Therapeutic Approaches for Breast Cancers awarded by Department of Defense 2015 - 2018
- MRI: Acquisition of a Triple Quadrupole LC/MS System awarded by National Science Foundation 2015 - 2018
- Targeting Rev1-mediated Translesion Synthesis for Cancer Therapy awarded by National Institutes of Health 2015 - 2017
- PKC zeta-Specific Inhibitors for Treatment of Methamphetamine Addiction awarded by National Institutes of Health 2009 - 2011
- Purchase of a Q-TOF LC/MS System awarded by National Institutes of Health 2010 - 2011
Publications & Artistic Works
Selected Publications
- Books
  - Toone, E. J. Preface. Vol. 78 1, 2011.
- Academic Articles
  - Lee, H, Sylvester, K, Derbyshire, ER, and Hong, J. "Synthesis and Analysis of Natural-Product-Like Macrocycles by Tandem Oxidation/Oxa-Conjugate Addition Reactions." Chemistry (Weinheim an Der Bergstrasse, Germany) 25, no. 26 (May 2019): 6500-6504. Full Text
  - Lee, M, Zhao, J, Kwak, S-H, Cho, J, Lee, M, Gillespie, RA, Kwon, D-Y, Lee, H, Park, H-J, Wu, Q, Zhou, P, and Hong, J. "Structure-Activity Relationship of Sulfonyl Piperazine LpxH Inhibitors Analyzed by an LpxE-Coupled Malachite Green Assay." Acs Infectious Diseases 5, no. 4 (April 2019): 641-651. Full Text
  - Eubanks, AL, Perkins, MM, Sylvester, K, Ganley, JG, Posfai, D, Sanschargrin, PC, Hong, J, Sliz, P, and Derbyshire, ER. "In silico Screening and Evaluation of Plasmodium falciparum Protein Kinase 5 (PK5) Inhibitors." Chemmedchem 13, no. 23 (December 2018): 2479-2483. Full Text
  - Kwon, D-Y, Lee, K, Park, H, Kim, MJ, and Hong, J. "Synthetic efforts towards the stereoselective synthesis of NF00659B1." Bioorganic & Medicinal Chemistry Letters 28, no. 16 (September 2018): 2746-2750. Full Text
  - Siska, PJ, Beckermann, KE, Mason, FM, Andrejeva, G, Greenplate, AR, Sendor, AB, Chiang, Y-CJ, Corona, AL, Gemta, LF, Vincent, BG, Wang, RC, Kim, B, Hong, J, Chen, C-L, Bullock, TN, Irish, JM, Rathmell, WK, and Rathmell, JC. "Mitochondrial dysregulation and glycolytic insufficiency functionally impair CD8 T cells infiltrating human renal cell carcinoma." Jci Insight 2, no. 12 (June 15, 2017). Full Text
  - Kim, Bumki, Ranjala Ratnayake, Hyunji Lee, Guqin Shi, Sabrina L. Zeller, Chenglong Li, Hendrik Luesch, and Jiyong Hong. “Synthesis and biological evaluation of largazole zinc-binding group analogs..” Bioorganic & Medicinal Chemistry 25, no. 12 (June 2017): 3077–86. https://doi.org/10.1016/j.bmc.2017.03.071.
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  - Lanier, Megan L., Hyeri Park, Paramita Mukherjee, Jacob C. Timmerman, Anthony A. Ribeiro, Ross A. Widenhoefer, and Jiyong Hong. “Formal Synthesis of (+)-Laurencin by Gold(I)-Catalyzed Intramolecular Dehydrative Alkoxylation..” Chemistry (Weinheim an Der Bergstrasse, Germany) 23, no. 30 (May 3, 2017): 7180–84. https://doi.org/10.1002/chem.201700499.
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  - Lee, Kiyoun, Megan L. Lanier, Jae-Hwan Kwak, Hyoungsu Kim, and Jiyong Hong. “Advances in the synthesis of glycosidic macrolides: clavosolides A-D and cyanolide A..” Natural Product Reports 33, no. 12 (November 2016): 1393–1424. https://doi.org/10.1039/c6np00073h.
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  - Siska, PJ, Kim, B, Ji, X, Hoeksema, MD, Massion, PP, Beckermann, KE, Wu, J, Chi, J-T, Hong, J, and Rathmell, JC. "Fluorescence-based measurement of cystine uptake through xCT shows requirement for ROS detoxification in activated lymphocytes." Journal of Immunological Methods 438 (November 2016): 51-58. Full Text
  - Geer Wallace, MA, Kwon, D-Y, Weitzel, DH, Lee, C-T, Stephenson, TN, Chi, J-T, Mook, RA, Dewhirst, MW, Hong, J, and Fitzgerald, MC. "Discovery of Manassantin A Protein Targets Using Large-Scale Protein Folding and Stability Measurements." Journal of Proteome Research 15, no. 8 (August 2016): 2688-2696. Full Text
  - Chung, BC, Mashalidis, EH, Tanino, T, Kim, M, Matsuda, A, Hong, J, Ichikawa, S, and Lee, S-Y. "Structural insights into inhibition of lipid I production in bacterial cell wall synthesis." Nature 533, no. 7604 (May 2016): 557-560. Full Text
  - Kwon, Do-Yeon, Hye Eun Lee, Douglas H. Weitzel, Kyunghye Park, Sun Hee Lee, Chen-Ting Lee, Tesia N. Stephenson, et al. “Synthesis and Biological Evaluation of Manassantin Analogues for Hypoxia-Inducible Factor 1α Inhibition..” Journal of Medicinal Chemistry 58, no. 19 (October 2015): 7659–71. https://doi.org/10.1021/acs.jmedchem.5b01220.
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  - Baker, Joseph B., Hyoungsu Kim, and Jiyong Hong. “Total Synthesis of Clavosolide A via Tandem Allylic Oxidation/Oxa-Conjugate Addition Reaction..” Tetrahedron Letters 56, no. 23 (June 2015): 3120–22. https://doi.org/10.1016/j.tetlet.2014.11.135.
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  - Lim, Wonchung, Joonwoo Park, Yong Hee Lee, Jiyong Hong, and YoungJoo Lee. “Subglutinol A, an immunosuppressive α-pyrone diterpenoid from Fusarium subglutinans, acts as an estrogen receptor antagonist..” Biochemical and Biophysical Research Communications 461, no. 3 (June 2015): 507–12. https://doi.org/10.1016/j.bbrc.2015.04.053.
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  - Kim, Bumki, and Jiyong Hong. “An overview of naturally occurring histone deacetylase inhibitors..” Current Topics in Medicinal Chemistry 14, no. 24 (January 2015): 2759–82. https://doi.org/10.2174/1568026615666141208105614.
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  - Kim, B, Park, H, Salvador, LA, Serrano, PE, Kwan, JC, Zeller, SL, Chen, QY, Ryu, S, Liu, Y, Byeon, S, Luesch, H, and Hong, J. "Evaluation of class i HDAC isoform selectivity of largazole analogues." Bioorganic and Medicinal Chemistry Letters 24, no. 16 (August 15, 2014): 3728-3731. Full Text
  - Hong, Jiyong. “Natural product synthesis at the interface of chemistry and biology..” Chemistry (Weinheim an Der Bergstrasse, Germany) 20, no. 33 (August 2014): 10204–12. https://doi.org/10.1002/chem.201402804.
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  - Kim, Bumki, Heekwang Park, Lilibeth A. Salvador, Patrick E. Serrano, Jason C. Kwan, Sabrina L. Zeller, Qi-Yin Chen, et al. “Evaluation of class I HDAC isoform selectivity of largazole analogues..” Bioorganic & Medicinal Chemistry Letters 24, no. 16 (August 2014): 3728–31. https://doi.org/10.1016/j.bmcl.2014.07.006.
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  - Salvador, Lilibeth A., Heekwang Park, Fatma H. Al-Awadhi, Yanxia Liu, Bumki Kim, Sabrina L. Zeller, Qi-Yin Chen, Jiyong Hong, and Hendrik Luesch. “Modulation of Activity Profiles for Largazole-Based HDAC Inhibitors through Alteration of Prodrug Properties..” Acs Medicinal Chemistry Letters 5, no. 8 (August 2014): 905–10. https://doi.org/10.1021/ml500170r.
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  - Johnson, Zachary Lee, Jun-Ho Lee, Kiyoun Lee, Minhee Lee, Do-Yeon Kwon, Jiyong Hong, and Seok-Yong Lee. “Structural basis of nucleoside and nucleoside drug selectivity by concentrative nucleoside transporters.” Elife 3 (July 31, 2014). https://doi.org/10.7554/eLife.03604.
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  - Johnson, ZL, Lee, J-H, Lee, K, Lee, M, Kwon, D-Y, Hong, J, and Lee, S-Y. "Structural basis of nucleoside and nucleoside drug selectivity by concentrative nucleoside transporters." Elife 3 (July 31, 2014): e03604-null. Full Text
  - Lanier, Megan L., Amanda C. Kasper, Hyoungsu Kim, and Jiyong Hong. “Synthesis of α,α'-trans-oxepanes through an organocatalytic oxa-conjugate addition reaction..” Organic Letters 16, no. 9 (May 2014): 2406–9. https://doi.org/10.1021/ol500773w.
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  - Lin, Regina, Hyoungsu Kim, Jiyong Hong, and Qi-Jing Li. “Biological evaluation of subglutinol a as a novel immunosuppressive agent for inflammation intervention..” Acs Medicinal Chemistry Letters 5, no. 5 (May 2014): 485–90. https://doi.org/10.1021/ml4004809.
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  - Yu, Mingming, Lilibeth A. Salvador, Sherwin K. B. Sy, Yufei Tang, Ravi S. P. Singh, Qi-Yin Chen, Yanxia Liu, Jiyong Hong, Hartmut Derendorf, and Hendrik Luesch. “Largazole pharmacokinetics in rats by LC-MS/MS..” Marine Drugs 12, no. 3 (March 20, 2014): 1623–40. https://doi.org/10.3390/md12031623.
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  - Strickland, Erin C., M Ariel Geer, Jiyong Hong, and Michael C. Fitzgerald. “False-positive rate determination of protein target discovery using a covalent modification- and mass spectrometry-based proteomics platform..” Journal of the American Society for Mass Spectrometry 25, no. 1 (January 2014): 132–40. https://doi.org/10.1007/s13361-013-0754-2.
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  - Chung, BC, Zhao, J, Gillespie, RA, Kwon, D-Y, Guan, Z, Hong, J, Zhou, P, and Lee, S-Y. "Crystal structure of MraY, an essential membrane enzyme for bacterial cell wall synthesis." Science (New York, N.Y.) 341, no. 6149 (August 2013): 1012-1016. Full Text
  - Law, M. E., P. E. Corsino, S. C. Jahn, B. J. Davis, S. Chen, B. Patel, K. Pham, et al. “Glucocorticoids and histone deacetylase inhibitors cooperate to block the invasiveness of basal-like breast cancer cells through novel mechanisms..” Oncogene 32, no. 10 (March 2013): 1316–29. https://doi.org/10.1038/onc.2012.138.
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  - Chung, B. C., J. Zhao, R. A. Gillespie, D. Y. Kwon, Z. Guan, J. Hong, P. Zhou, and S. Y. Lee. “Crystal structure of MraY, an essential membrane enzyme for bacterial cell wall synthesis.” Science 341, no. 6149 (2013): 1012–16. https://doi.org/10.1126/science.1240985.
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  - Law, M. E., P. E. Corsino, S. C. Jahn, B. J. Davis, S. Chen, B. Patel, K. Pham, et al. “Glucocorticoids and histone deacetylase inhibitors cooperate to block the invasiveness of basal-like breast cancer cells through novel mechanisms.” Oncogene 32, no. 10 (2013): 1316–29. https://doi.org/10.1038/onc.2012.138.
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  - Kaoud, Tamer S., Heekwang Park, Shreya Mitra, Chunli Yan, Chun-Chia Tseng, Yue Shi, Jiney Jose, et al. “Manipulating JNK signaling with (--)-zuonin A..” Acs Chemical Biology 7, no. 11 (November 2012): 1873–83. https://doi.org/10.1021/cb300261e.
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  - Kaoud, TS, Yan, C, Mitra, S, Tseng, C-C, Jose, J, Taliaferro, JM, Tuohetahuntila, M, Devkota, A, Sammons, R, Park, J, Park, H, Shi, Y, Hong, J, Ren, P, and Dalby, KN. "From in Silico Discovery to intra-Cellular Activity: Targeting JNK-Protein Interactions with Small Molecules." Acs Medicinal Chemistry Letters 3, no. 9 (August 2012): 721-725. Full Text
  - Lee, Kiyoun, Hyoungsu Kim, and Jiyong Hong. “N-Heterocyclic carbene catalyzed oxidative macrolactonization: total synthesis of (+)-dactylolide..” Angewandte Chemie (International Ed. in English) 51, no. 23 (June 2012): 5735–38. https://doi.org/10.1002/anie.201201653.
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  - Hong, J, and Luesch, H. "Largazole: from discovery to broad-spectrum therapy." Natural Product Reports 29, no. 4 (April 2012): 449-456. (Review) Full Text
  - Lee, Won-Gil, Woo-Seok Kim, Sung-Gyoo Park, Hyoungsu Kim, Jiyong Hong, Hyojin Ko, and Yong-Chul Kim. “Immunosuppressive effects of subglutinol derivatives..” Chemmedchem 7, no. 2 (February 2012): 218–22. https://doi.org/10.1002/cmdc.201100409.
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  - Lee, K, Kim, H, and Hong, J. "Stereoselective synthesis of tetrahydropyrans through tandem and organocatalytic oxa-Michael reactions: Synthesis of the tetrahydropyran cores of ent-(+)-sorangicin A." European Journal of Organic Chemistry , no. 5 (February 1, 2012): 1025-1032. Full Text
  - Byeon, Seong Rim, Heekwang Park, Hyoungsu Kim, and Jiyong Hong. “Stereoselective synthesis of 2,6-trans-tetrahydropyran via primary diamine-catalyzed oxa-conjugate addition reaction of α,β-unsaturated ketone: total synthesis of psymberin..” Organic Letters 13, no. 21 (November 2011): 5816–19. https://doi.org/10.1021/ol2024289.
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  - Park, Heekwang, Hyoungsu Kim, and Jiyong Hong. “A Formal Synthesis of SCH 351448.” Organic Letters 13, no. 14 (July 15, 2011): 3742–45. https://doi.org/10.1021/ol201426c.
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  - Park, Heekwang, Hyoungsu Kim, and Jiyong Hong. “A formal synthesis of SCH 351448..” Organic Letters 13, no. 14 (July 2011): 3742–45. https://doi.org/10.1021/ol201426c.
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  - Hong, Jiyong. “Role of natural product diversity in chemical biology..” Current Opinion in Chemical Biology 15, no. 3 (June 2011): 350–54. https://doi.org/10.1016/j.cbpa.2011.03.004.
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  - Kim, H, Byeon, SR, Leed, MGD, and Hong, J. "Intramolecular Michael reactions of aliphatic aldehyde enolates generated by imidazolium carbenes." Tetrahedron Letters 52, no. 19 (May 11, 2011): 2468-2470. Full Text
  - Harrington, James M., Heekwang Park, Yongcheng Ying, Jiyong Hong, and Alvin L. Crumbliss. “Characterization of Fe(III) sequestration by an analog of the cytotoxic siderophore brasilibactin A: implications for the iron transport mechanism in mycobacteria..” Metallomics : Integrated Biometal Science 3, no. 5 (May 2011): 464–71. https://doi.org/10.1039/c0mt00109k.
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  - Lee, Kiyoun, Hyoungsu Kim, and Jiyong Hong. “A stereoselective formal synthesis of leucascandrolide A..” Organic Letters 13, no. 10 (May 2011): 2722–25. https://doi.org/10.1021/ol200824r.
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  - Lee, Su-Ui, Han Bok Kwak, Sung-Hee Pi, Hyung-Keun You, Seong Rim Byeon, Yongcheng Ying, Hendrik Luesch, Jiyong Hong, and Seong Hwan Kim. “In Vitro and In Vivo Osteogenic Activity of Largazole..” Acs Medicinal Chemistry Letters 2, no. 3 (March 2011): 248–51. https://doi.org/10.1021/ml1002794.
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  - Ying, Yongcheng, Hyoungsu Kim, and Jiyong Hong. “Stereoselective synthesis of 2,6-cis- and 2,6-trans-piperidines through organocatalytic aza-Michael reactions: a facile synthesis of (+)-myrtine and (-)-epimyrtine..” Organic Letters 13, no. 4 (February 2011): 796–99. https://doi.org/10.1021/ol103064f.
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  - Liu, Yanxia, Lilibeth A. Salvador, Seongrim Byeon, Yongcheng Ying, Jason C. Kwan, Brian K. Law, Jiyong Hong, and Hendrik Luesch. “Anticolon cancer activity of largazole, a marine-derived tunable histone deacetylase inhibitor..” The Journal of Pharmacology and Experimental Therapeutics 335, no. 2 (November 2010): 351–61. https://doi.org/10.1124/jpet.110.172387.
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  - Kim, Hyoungsu, Joseph B. Baker, Yongho Park, Hyung-Bae Park, Patrick D. DeArmond, Seong Hwan Kim, Michael C. Fitzgerald, Dong-Sup Lee, and Jiyong Hong. “Total synthesis, assignment of the absolute stereochemistry, and structure-activity relationship studies of subglutinols A and B..” Chemistry, an Asian Journal 5, no. 8 (August 2010): 1902–10. https://doi.org/10.1002/asia.201000147.
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  - Kim, Hyoungsu, and Jiyong Hong. “Total synthesis of cyanolide A and confirmation of its absolute configuration..” Organic Letters 12, no. 12 (June 2010): 2880–83. https://doi.org/10.1021/ol101022z.
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  - Lee, Kiyoun, Hyoungsu Kim, and Jiyong Hong. “A facile and efficient synthesis of 4-hydroxy-2,6-cis-tetrahydropyrans via tandem cross-metathesis/thermal S(N)2' reaction: protecting-group-free synthesis of (+/-)-diospongin A..” Organic Letters 11, no. 22 (November 2009): 5202–5. https://doi.org/10.1021/ol902125d.
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  - Yuan, Langtian, Jin-Soo Seo, Nam Sook Kang, Shahar Keinan, Sarah E. Steele, Gregory A. Michelotti, William C. Wetsel, et al. “Identification of 3-hydroxy-2-(3-hydroxyphenyl)-4H-1-benzopyran-4-ones as isoform-selective PKC-zeta inhibitors and potential therapeutics for psychostimulant abuse..” Molecular Biosystems 5, no. 9 (September 2009): 927–30. https://doi.org/10.1039/b903036k.
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  - Kasper, Amanda C., Eui Jung Moon, Xiangqian Hu, Yongho Park, Ceshea M. Wooten, Hyoungsu Kim, Weitao Yang, Mark W. Dewhirst, and Jiyong Hong. “Analysis of HIF-1 inhibition by manassantin A and analogues with modified tetrahydrofuran configurations..” Bioorganic & Medicinal Chemistry Letters 19, no. 14 (July 2009): 3783–86. https://doi.org/10.1016/j.bmcl.2009.04.071.
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  - Kasper, Amanda C., Joseph B. Baker, Hyoungsu Kim, and Jiyong Hong. “The end game of chemical genetics: target identification..” Future Medicinal Chemistry 1, no. 4 (July 2009): 727–36. https://doi.org/10.4155/fmc.09.52.
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  - Kim, H, Kasper, AC, Moon, EJ, Park, Y, Wooten, CM, Dewhirst, MW, and Hong, J. "Nucleophilic Addition of Organozinc Reagents to 2-Sulfonyl Cyclic Ethers: Stereoselective Synthesis of Manassantins A and B (Org. Lett., (2009) 11:7 (1671-1671)." Organic Letters 11, no. 7 (April 2, 2009): 1671-null. Full Text
  - Kim, Hyoungsu, Joseph B. Baker, Su-Ui Lee, Yongho Park, Kyle L. Bolduc, Hyung-Bae Park, Marina G. Dickens, et al. “Stereoselective synthesis and osteogenic activity of subglutinols A and B..” Journal of the American Chemical Society 131, no. 9 (March 2009): 3192–94. https://doi.org/10.1021/ja8101192.
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  - Lee, J, Hong, J, Nam, T-G, Peters, EC, Orth, AP, Geierstanger, BH, Goldfinger, LE, Ginsberg, MH, Cho, CY, and Schultz, PG. "A small molecule inhibitor of alpha4 integrin-dependent cell migration." Bioorganic & Medicinal Chemistry 17, no. 3 (February 2009): 977-980. Full Text
  - Kim, Hyoungsu, Amanda C. Kasper, Eui Jung Moon, Yongho Park, Ceshea M. Wooten, Mark W. Dewhirst, and Jiyong Hong. “Nucleophilic addition of organozinc reagents to 2-sulfonyl cyclic ethers: stereoselective synthesis of manassantins A and B..” Organic Letters 11, no. 1 (January 2009): 89–92. https://doi.org/10.1021/ol8024617.
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  - Kim, Hyoungsu, Yongho Park, and Jiyong Hong. “Stereoselective synthesis of 2,6-cis-tetrahydropyrans through a tandem allylic oxidation/oxa-Michael reaction promoted by the gem-disubstituent effect: synthesis of (+)-neopeltolide macrolactone..” Angewandte Chemie (International Ed. in English) 48, no. 41 (January 2009): 7577–81. https://doi.org/10.1002/anie.200903690.
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  - Ying, Yongcheng, Yanxia Liu, Seong Rim Byeon, Hyoungsu Kim, Hendrik Luesch, and Jiyong Hong. “Synthesis and activity of largazole analogues with linker and macrocycle modification..” Organic Letters 10, no. 18 (September 2008): 4021–24. https://doi.org/10.1021/ol801532s.
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  - Ying, Yongcheng, Kanchan Taori, Hyoungsu Kim, Jiyong Hong, and Hendrik Luesch. “Total synthesis and molecular target of largazole, a histone deacetylase inhibitor..” Journal of the American Chemical Society 130, no. 26 (July 2008): 8455–59. https://doi.org/10.1021/ja8013727.
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  - Lee, Hyunjoo, Kwan Woo Kim, Janghyun Park, Hyoungsu Kim, Sanghee Kim, Deukjoon Kim, Xiangqian Hu, Weitao Yang, and Jiyong Hong. “A general strategy for construction of both 2,6-cis- and 2,6-trans-disubstituted tetrahydropyrans: substrate-controlled asymmetric total synthesis of (+)-scanlonenyne..” Angewandte Chemie (International Ed. in English) 47, no. 22 (January 2008): 4200–4203. https://doi.org/10.1002/anie.200705663.
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  - Ying, Y, and Hong, J. "Synthesis of brasilibactin A and confirmation of absolute configuration of β-hydroxy acid fragment." Tetrahedron Letters 48, no. 46 (November 12, 2007): 8104-8107. Full Text
  - Lee, J, Wu, X, Pasca di Magliano, M, Peters, EC, Wang, Y, Hong, J, Hebrok, M, Ding, S, Cho, CY, and Schultz, PG. "A small-molecule antagonist of the hedgehog signaling pathway." Chembiochem : a European Journal of Chemical Biology 8, no. 16 (November 2007): 1916-1919. Full Text
  - Kim, H, Wooten, CM, Park, Y, and Hong, J. "Stereoselective synthesis of tetrahydrofuran lignans via BF(3) x OEt(2)-promoted reductive deoxygenation/epimerization of cyclic hemiketal: synthesis of (-)-odoratisol C, (-)-futokadsurin A, (-)-veraguensin, (+)-fragransin A(2), (+)-galbelgin, and (+)-talaumidin." Organic Letters 9, no. 20 (September 2007): 3965-3968. Full Text
  - Hong, J, Lee, J, Min, KH, Walker, JR, Peters, EC, Gray, NS, Cho, CY, and Schultz, PG. "Identification and characterization of small-molecule inducers of epidermal keratinocyte differentiation." Acs Chemical Biology 2, no. 3 (March 9, 2007): 171-175. Full Text
  - Collins, Cynthia S., Jiyong Hong, Lisa Sapinoso, Yingyao Zhou, Zheng Liu, Kenneth Micklash, Peter G. Schultz, and Garret M. Hampton. “A small interfering RNA screen for modulators of tumor cell motility identifies MAP4K4 as a promigratory kinase..” Proceedings of the National Academy of Sciences of the United States of America 103, no. 10 (March 2006): 3775–80. https://doi.org/10.1073/pnas.0600040103.
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  - Lee, Jongkook, and Jiyong Hong. “First synthesis and structural elucidation of (-)-presphaerene..” The Journal of Organic Chemistry 69, no. 19 (September 2004): 6433–40. https://doi.org/10.1021/jo049351c.
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  - Boger, D. L., and J. Hong. “Asymmetric total synthesis of ent-(-)-roseophilin: assignment of absolute configuration..” Journal of the American Chemical Society 123, no. 35 (September 2001): 8515–19. https://doi.org/10.1021/ja011271s.
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  - Boger, DL, Hong, J, Hikota, M, and Ishida, M. "Total synthesis of phomazarin." Journal of the American Chemical Society 121, no. 11 (March 24, 1999): 2471-2477. Full Text
  - Kim, D, Choi, WJ, Hong, JY, Park, Y, and Kim, YB. "An asymmetric synthesis of (+)-isonitramine by 'triple allylic strain-controlled' intramolecular SN2' alkylation." Tetrahedron Letters 37, no. 9 (February 26, 1996): 1433-1434. Full Text
  - Boger, DL, and Hong, J. "Total synthesis of nothapodytine b and (-)-mappicine." Journal of the American Chemical Society 120, no. 6 (February 18, 1998): 1218-1222. Full Text
- Book Sections
  - Garbaccio, Robert M., Douglas S. Johnson, Jiyong Hong, and Matthew D. Disney. “Preface.,” Vol. 25, 2015. https://doi.org/10.1016/j.bmcl.2015.08.083.
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- Conference Papers
  - Lee, H, and Hong, J. "Design and synthesis of a natural product-like macrocycle library containing tetrahydropyran moieties." 256th National Meeting and Exposition of the American-Chemical-Society (ACS) - Nanoscience, Nanotechnology and Beyond. Boston, MA. August 19, 2018 - August 23, 2018.: AMER CHEMICAL SOC, August 19, 2018. Link to Item
  - Lee, M, Zhao, J, Cho, J, Kwon, D-Y, Zhou, P, and Hong, J. "Synthesis and biological evaluation of sulfonyl piperazine derivatives for LpxH inhibition." 253rd National Meeting of the American-Chemical-Society (ACS) on Advanced Materials, Technologies, Systems, and Processes. San Francisco, CA. April 2, 2017 - April 6, 2017.: AMER CHEMICAL SOC, April 2, 2017. Link to Item
  - Park, H, Lanier, M, Mukherjee, P, Ribeiro, A, Widenhoefer, R, and Hong, J. "Exploration of gold(I)-catalyzed alkoxylation for formal synthesis of (+)-laurencin." 253rd National Meeting of the American-Chemical-Society (ACS) on Advanced Materials, Technologies, Systems, and Processes. San Francisco, CA. April 2, 2017 - April 6, 2017.: AMER CHEMICAL SOC, April 2, 2017. Link to Item
  - Kwon, D-Y, Park, K, Weitzel, D, Lee, SH, Stephenson, T, Lee, C-T, Chi, J-T, Mook, R, Dewhirst, M, Lee, YM, and Hong, J. "Design, synthesis, and biological evaluation of manassantin analogues for HIF-1 alpha inhibition." : AMER CHEMICAL SOC, March 22, 2015. Link to Item
  - Lanier, Megan L., Amanda C. Kasper, Hyoungsu Kim, and Jiyong Hong. “Stereoselective synthesis of alpha,alpha '-trans-oxepanes through an organocatalytic oxa-conjugate addition reaction.” In Abstracts of Papers of the American Chemical Society, Vol. 247. AMER CHEMICAL SOC, 2014.
    Link to Item
  - Chung, BC, Zhao, J, Gillespie, R, Kwon, DY, Guan, Z, Hong, J, Zhou, P, and Lee, S-Y. "Crystal Structure of MraY, an Essential Membrane Enzyme for Bacterial Cell Wall Synthesis." : Elsevier BV, January 2014. Full Text
  - Lee, Kiyoun, Hyoungsu Kim, and Jiyong Hong. “Stereoselective formal synthesis of leucascandrolide A.” In Abstracts of Papers of the American Chemical Society, Vol. 242. AMER CHEMICAL SOC, 2011.
    Link to Item
  - Ying, Yongcheng, Hyoungsu Kim, and Jiyong Hong. “Efficient and stereoselective synthesis of 2,6-disubstituted piperidines through an organocatalytic aza-Michael reaction promoted by the gem-disubstituent effect.” In Abstracts of Papers of the American Chemical Society, Vol. 239. AMER CHEMICAL SOC, 2010.
    Link to Item
  - Harrington, James M., Heekwang Park, Yongcheng Ying, Jiyong Hong, and Alvin L. Crumbliss. “Thermodynamic characterization of iron(III) and zinc binding by Brasilibactin A.” In Abstracts of Papers of the American Chemical Society, Vol. 238. AMER CHEMICAL SOC, 2009.
    Link to Item
  - Ying, Yongcheng, Hyoungsu Kim, Kanchan Taori, Hendrik Luesch, and Jiyong Hong. “ORGN 523-Total synthesis of largazole.” In Abstracts of Papers of the American Chemical Society, Vol. 236. AMER CHEMICAL SOC, 2008.
    Link to Item
Teaching & Mentoring
Recent Courses
- CHEM 201DL: Organic Chemistry I 2019
- CHEM 393: Research Independent Study 2019
- CHEM 394: Research Independent Study 2019
- CHEM 493: Research Independent Study 2019
- CHEM 494: Research Independent Study 2019
- CHEM 535: Organic Synthesis 2019
- CHEM 801: Research 2017
Scholarly, Clinical, & Service Activities
Presentations & Appearances
Service to the Profession
- Editorial Board Member : Archives of Pharmacal Research. 2013 2013
- Editorial Board, Archives of Pharmacal Research, Springer. December 6, 2011 2011

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Education, Training, & Certifications

Duke Appointment History

Selected Grants

Selected Publications

Books

Academic Articles

Book Sections

Conference Papers

Recent Courses

Presentations & Appearances

Service to the Profession