Jiyong Hong | Scholars@Duke

Jiyong Hong
Professor of Chemistry

Research in the Hong group focuses on using chemical tools, in particular small molecules, to understand the signaling pathways in biology. We synthesize biologically interesting natural products and screen small molecule libraries to identify modulators of biological processes. Then, we explore their modes of action in order to investigate intracellular signaling pathways and identify novel targets for drug design. In addition, we design and develop unique and efficient synthetic strategies that will allow rapid access to molecular complexity and structural diversity. Through multidisciplinary approaches, including organic synthesis, molecular biology, and cell biology, the cellular components and molecular events that embody cancer, immune response, and GPCR signaling have systematically been explored. Compounds employed in these studies could also advance the development of novel therapeutics for the treatment of human diseases.

Synthesis of Natural Products and Study of Mode of Action: We synthesize biologically interesting natural products and explore the modes of action in order to investigate intracellular signaling pathways and identify novel targets for drug design. Completed target molecules include largazole (a marine natural product with HDAC inhibitory activity), brasilibactin A (a cytotoxic siderophore), manassantins A and B (natural products with anti-HIF-1 activity), and subglutinols A and B (natural products with immunosuppressive activity).
Development of Novel Synthetic Methodology: We design and develop unique and efficient synthetic strategies which will allow rapid access to molecular complexity and structural diversity. A specific area of interest includes the development of novel methods for the stereoselective synthesis of substituted tetrahydrofurans and tetrahydropyrans.
Screen of Small Molecule Libraries for Identification of Small Molecule Modulators of Biological Processes: With the advent of combinatorial chemistry and other synthetic technologies, it is feasible to prepare large collections of synthetic organic molecules. These libraries are useful in providing molecules that can be used to probe relevant biological pathways. We are interested in identification of modulators of biological processes, including drug abuse and neurodegenerative diseases.

Through multidisciplinary approaches, the cellular components and molecular events that embody cancer, immune response, and neurodegenerative diseases are systematically explored. Compounds employed in these studies could also advance the development of novel therapeutics for the treatment of human diseases.

Current Appointments & Affiliations

Professor of Chemistry, Chemistry, Trinity College of Arts & Sciences 2017
Associate Chair of Chemistry, Chemistry, Trinity College of Arts & Sciences 2019
Associate Professor of Pharmacology and Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2013
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2005

Contact Information

3220 French Science Center, 124 Science Drive, Durham, NC 27708
Box 90346, Durham, NC 27708-0347
jiyong.hong@duke.edu (919) 660-1545
Hong Research Group

Background
Education, Training, & Certifications
- Ph.D., The Scripps Research Institute 2001
- M.S., Seoul National University (South Korea) 1995
- B.S., Seoul National University (South Korea) 1993
Previous Appointments & Affiliations
- Director of Undergraduate Studies in Chemistry, Chemistry, Trinity College of Arts & Sciences 2020
- Associate Professor of Chemistry, Chemistry, Trinity College of Arts & Sciences 2011 - 2017
- Director of Graduate Studies in the Department of Chemistry, Chemistry, Trinity College of Arts & Sciences 2013 - 2016
- Assistant Professor of Chemistry, Chemistry, Trinity College of Arts & Sciences 2005 - 2011
Research
Selected Grants
- Neuroactive steroids as novel psychiatric treatments: mechanistic studies awarded by Washington University in St. Louis 2021 - 2026
- Pharmacological Sciences Training Grant awarded by National Institutes of Health 2020 - 2025
- Development of MESH1 inhibitors to treat ferroptosis-associated neurodegeneration awarded by National Institutes of Health 2022 - 2024
- TRPM8 in eye health and disease awarded by National Institutes of Health 2020 - 2024
- Structural and chemical biology of human equilibrative nucleoside transporters awarded by National Institutes of Health 2020 - 2024
- Interrogating the cholinergic basis of opioid reinforcement with subcellular precision awarded by National Institutes of Health 2020 - 2023
- Discovery and validation of broadly effective LpxH inhibitors as novel therapeutics against multi-drug resistant Gram-negative pathogens awarded by National Institutes of Health 2019 - 2023
- Testing D5 compounds in a human version of a published ELISA system awarded by D5 Therapeutics, Inc 2021 - 2022
- Structural Biological Development of Fungal-Specific Calcineurin Inhibitors awarded by National Institutes of Health 2014 - 2022
- Structure guided design of novel adenosine reuptake inhibitors awarded by American Heart Association 2020 - 2021
- Structural and Mechanistic Characterization of MraY Catalysis and Inhibition awarded by National Institutes of Health 2017 - 2020
- Pharmacological Sciences Training Program awarded by National Institutes of Health 1975 - 2020
- GAANN - Department of Chemistry awarded by Department of Education 2015 - 2019
- Thermo Lumos Tribrid High-Resolution Accurate-Mass Tandem Mass Spectrometer awarded by National Institutes of Health 2018 - 2019
- Discovery and validation of broadly effective LpxH inhibitors as novel therapeutics against multi-drug resistant Gram-negative pathogens awarded by National Institutes of Health 2018 - 2019
- Study of Subglutinol A as a Potential Immunomodulatory Agent awarded by National Institutes of Health 2016 - 2018
- Human Stringent Response as Novel Therapeutic Approaches for Breast Cancers awarded by Department of Defense 2015 - 2018
- MRI: Acquisition of a Triple Quadrupole LC/MS System awarded by National Science Foundation 2015 - 2018
- Targeting Rev1-mediated Translesion Synthesis for Cancer Therapy awarded by National Institutes of Health 2015 - 2017
- PKC zeta-Specific Inhibitors for Treatment of Methamphetamine Addiction awarded by National Institutes of Health 2009 - 2011
- Purchase of a Q-TOF LC/MS System awarded by National Institutes of Health 2010 - 2011
External Relationships
- D5 Therapeutics
Publications & Artistic Works
Selected Publications
- Books
  - Toone, E. J. Preface. Vol. 78 1, 2011.
- Academic Articles
  - Wright, Nicholas J., Justin G. Fedor, Han Zhang, Pyeonghwa Jeong, Yang Suo, Jiho Yoo, Jiyong Hong, Wonpil Im, and Seok-Yong Lee. “Methotrexate recognition by the human reduced folate carrier SLC19A1.” Nature 609, no. 7929 (September 2022): 1056–62. https://doi.org/10.1038/s41586-022-05168-0.
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  - Hoy, Michael J., Eunchong Park, Hyunji Lee, Won Young Lim, D Christopher Cole, Nicholas D. DeBouver, Benjamin G. Bobay, et al. “Structure-Guided Synthesis of FK506 and FK520 Analogs with Increased Selectivity Exhibit In Vivo Therapeutic Efficacy against Cryptococcus.” Mbio 13, no. 3 (June 28, 2022): e0104922. https://doi.org/10.1128/mbio.01049-22.
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  - Victor, Joshua, Tristan Jordan, Erica Lamkin, Kanayo Ikeh, Anthony March, Justin Frere, Andrew Crompton, et al. “SARS-CoV-2 hijacks host cell genome instability pathways.” Res Sq, April 14, 2022. https://doi.org/10.21203/rs.3.rs-1556634/v1.
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  - Ikeh, Kanayo E., Erica N. Lamkin, Andrew Crompton, Jamie Deutsch, Kira J. Fisher, Mark Gray, David J. Argyle, et al. “REV1 Inhibition Enhances Radioresistance and Autophagy.” Cancers (Basel) 13, no. 21 (October 21, 2021). https://doi.org/10.3390/cancers13215290.
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  - Ikeh, Kanayo, Erica Lamkin, Andrew Crompton, Jamie Deutsch, Kira Fisher, Mark E. Gray, David Argyle, et al. “REV1 Inhibition Enhances Radioresistance and Autophagy,” September 13, 2021. https://doi.org/10.20944/preprints202109.0202.v1.
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  - Webster, Caroline G., Hyeri Park, Amanda F. Ennis, and Jiyong Hong. “Synthetic efforts toward the bicyclo[3.2.1]octane fragment of rhodojaponin III.” Tetrahedron Letters 71 (May 2021): 153055. https://doi.org/10.1016/j.tetlet.2021.153055.
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  - Zhou, Pei, and Jiyong Hong. “Structure- and Ligand-Dynamics-Based Design of Novel Antibiotics Targeting Lipid A Enzymes LpxC and LpxH in Gram-Negative Bacteria.” Acc Chem Res 54, no. 7 (April 6, 2021): 1623–34. https://doi.org/10.1021/acs.accounts.0c00880.
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  - Kwak, Seung-Hwa, Won Young Lim, Aili Hao, Ellene H. Mashalidis, Do-Yeon Kwon, Pyeonghwa Jeong, Mi Jung Kim, Seok-Yong Lee, and Jiyong Hong. “Synthesis and evaluation of cyclopentane-based muraymycin analogs targeting MraY.” Eur J Med Chem 215 (April 5, 2021): 113272. https://doi.org/10.1016/j.ejmech.2021.113272.
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  - Chatterjee, Nimrat, Matthew A. Whitman, Cynthia A. Harris, Sophia M. Min, Oliver Jonas, Evan C. Lien, Alba Luengo, et al. “REV1 inhibitor JH-RE-06 enhances tumor cell response to chemotherapy by triggering senescence hallmarks.” Proc Natl Acad Sci U S A 117, no. 46 (November 17, 2020): 28918–21. https://doi.org/10.1073/pnas.2016064117.
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  - Kwak, Seung-Hwa, C Skyler Cochrane, Amanda F. Ennis, Won Young Lim, Caroline G. Webster, Jae Cho, Benjamin A. Fenton, Pei Zhou, and Jiyong Hong. “Synthesis and evaluation of sulfonyl piperazine LpxH inhibitors.” Bioorg Chem 102 (September 2020): 104055. https://doi.org/10.1016/j.bioorg.2020.104055.
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  - Kwak, Seung-Hwa, Tesia N. Stephenson, Hye-Eun Lee, Yun Ge, Hyunji Lee, Sophia M. Min, Jea Hyun Kim, Do-Yeon Kwon, You Mie Lee, and Jiyong Hong. “Evaluation of Manassantin A Tetrahydrofuran Core Region Analogues and Cooperative Therapeutic Effects with EGFR Inhibition.” Journal of Medicinal Chemistry 63, no. 13 (July 2020): 6821–33. https://doi.org/10.1021/acs.jmedchem.0c00151.
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  - Neal, Samantha E., Kristen L. Buehne, Nicholas A. Besley, Ping Yang, Peter Silinski, Jiyong Hong, Ian T. Ryde, Joel N. Meyer, and Glenn J. Jaffe. “Resveratrol Protects Against Hydroquinone-Induced Oxidative Threat in Retinal Pigment Epithelial Cells.” Invest Ophthalmol Vis Sci 61, no. 4 (April 9, 2020): 32. https://doi.org/10.1167/iovs.61.4.32.
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  - Cho, Jae, Minhee Lee, C Skyler Cochrane, Caroline G. Webster, Benjamin A. Fenton, Jinshi Zhao, Jiyong Hong, and Pei Zhou. “Structural basis of the UDP-diacylglucosamine pyrophosphohydrolase LpxH inhibition by sulfonyl piperazine antibiotics.” Proc Natl Acad Sci U S A 117, no. 8 (February 25, 2020): 4109–16. https://doi.org/10.1073/pnas.1912876117.
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  - Choi, H., J. Hong, and K. Lee. “A Stereoselective Formal Synthesis of Quinolizidine (–)-217A.” European Journal of Organic Chemistry 2020, no. 6 (February 14, 2020): 689–92. https://doi.org/10.1002/ejoc.201901680.
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  - Chhetri, Abhishek, Anna Loksztejn, Hai Nguyen, Kaila M. Pianalto, Mi Jung Kim, Jiyong Hong, J Andrew Alspaugh, and Kenichi Yokoyama. “Length Specificity and Polymerization Mechanism of (1,3)-β-d-Glucan Synthase in Fungal Cell Wall Biosynthesis.” Biochemistry 59, no. 5 (February 11, 2020): 682–93. https://doi.org/10.1021/acs.biochem.9b00896.
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  - Park, Hyeri, Laura S. Christian, Mi Jung Kim, Qi-Jing Li, and Jiyong Hong. “Synthesis and Biological Evaluation of Subglutinol Analogs for Immunomodulatory Agents.” J Med Chem 63, no. 1 (January 9, 2020): 283–94. https://doi.org/10.1021/acs.jmedchem.9b01579.
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  - Mashalidis, Ellene H., Benjamin Kaeser, Yuma Terasawa, Akira Katsuyama, Do-Yeon Kwon, Kiyoun Lee, Jiyong Hong, Satoshi Ichikawa, and Seok-Yong Lee. “Chemical logic of MraY inhibition by antibacterial nucleoside natural products.” Nat Commun 10, no. 1 (July 2, 2019): 2917. https://doi.org/10.1038/s41467-019-10957-9.
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  - Wojtaszek, Jessica L., Nimrat Chatterjee, Javaria Najeeb, Azucena Ramos, Minhee Lee, Ke Bian, Jenny Y. Xue, et al. “A Small Molecule Targeting Mutagenic Translesion Synthesis Improves Chemotherapy.” Cell 178, no. 1 (June 2019): 152-159.e11. https://doi.org/10.1016/j.cell.2019.05.028.
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  - Lee, Hyunji, Kayla Sylvester, Emily R. Derbyshire, and Jiyong Hong. “Synthesis and Analysis of Natural-Product-Like Macrocycles by Tandem Oxidation/Oxa-Conjugate Addition Reactions.” Chemistry (Weinheim an Der Bergstrasse, Germany) 25, no. 26 (May 2019): 6500–6504. https://doi.org/10.1002/chem.201900620.
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  - Lee, Minhee, Jinshi Zhao, Seung-Hwa Kwak, Jae Cho, Myungju Lee, Robert A. Gillespie, Do-Yeon Kwon, et al. “Structure-Activity Relationship of Sulfonyl Piperazine LpxH Inhibitors Analyzed by an LpxE-Coupled Malachite Green Assay.” Acs Infect Dis 5, no. 4 (April 12, 2019): 641–51. https://doi.org/10.1021/acsinfecdis.8b00364.
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  - Eubanks, Amber L., Marisha M. Perkins, Kayla Sylvester, Jack G. Ganley, Dora Posfai, Paul C. Sanschargrin, Jiyong Hong, Piotr Sliz, and Emily R. Derbyshire. “In silico Screening and Evaluation of Plasmodium falciparum Protein Kinase 5 (PK5) Inhibitors.” Chemmedchem 13, no. 23 (December 2018): 2479–83. https://doi.org/10.1002/cmdc.201800625.
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  - Kwon, Do-Yeon, Kiyoun Lee, Hyeri Park, Mi Jung Kim, and Jiyong Hong. “Synthetic efforts towards the stereoselective synthesis of NF00659B₁.” Bioorganic & Medicinal Chemistry Letters 28, no. 16 (September 2018): 2746–50. https://doi.org/10.1016/j.bmcl.2018.02.038.
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  - Siska, Peter J., Kathryn E. Beckermann, Frank M. Mason, Gabriela Andrejeva, Allison R. Greenplate, Adam B. Sendor, Yun-Chen J. Chiang, et al. “Mitochondrial dysregulation and glycolytic insufficiency functionally impair CD8 T cells infiltrating human renal cell carcinoma.” Jci Insight 2, no. 12 (June 15, 2017). https://doi.org/10.1172/jci.insight.93411.
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  - Kim, Bumki, Ranjala Ratnayake, Hyunji Lee, Guqin Shi, Sabrina L. Zeller, Chenglong Li, Hendrik Luesch, and Jiyong Hong. “Synthesis and biological evaluation of largazole zinc-binding group analogs.” Bioorganic & Medicinal Chemistry 25, no. 12 (June 2017): 3077–86. https://doi.org/10.1016/j.bmc.2017.03.071.
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  - Lanier, Megan L., Hyeri Park, Paramita Mukherjee, Jacob C. Timmerman, Anthony A. Ribeiro, Ross A. Widenhoefer, and Jiyong Hong. “Formal Synthesis of (+)-Laurencin by Gold(I)-Catalyzed Intramolecular Dehydrative Alkoxylation.” Chemistry (Weinheim an Der Bergstrasse, Germany) 23, no. 30 (May 2017): 7180–84. https://doi.org/10.1002/chem.201700499.
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  - Lee, Kiyoun, Megan L. Lanier, Jae-Hwan Kwak, Hyoungsu Kim, and Jiyong Hong. “Advances in the synthesis of glycosidic macrolides: clavosolides A-D and cyanolide A.” Natural Product Reports 33, no. 12 (November 2016): 1393–1424. https://doi.org/10.1039/c6np00073h.
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  - Siska, Peter J., Bumki Kim, Xiangming Ji, Megan D. Hoeksema, Pierre P. Massion, Kathryn E. Beckermann, Jianli Wu, Jen-Tsan Chi, Jiyong Hong, and Jeffrey C. Rathmell. “Fluorescence-based measurement of cystine uptake through xCT shows requirement for ROS detoxification in activated lymphocytes.” J Immunol Methods 438 (November 2016): 51–58. https://doi.org/10.1016/j.jim.2016.08.013.
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  - Geer Wallace, M Ariel, Do-Yeon Kwon, Douglas H. Weitzel, Chen-Ting Lee, Tesia N. Stephenson, Jen-Tsan Chi, Robert A. Mook, Mark W. Dewhirst, Jiyong Hong, and Michael C. Fitzgerald. “Discovery of Manassantin A Protein Targets Using Large-Scale Protein Folding and Stability Measurements.” J Proteome Res 15, no. 8 (August 5, 2016): 2688–96. https://doi.org/10.1021/acs.jproteome.6b00237.
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  - Chung, Ben C., Ellene H. Mashalidis, Tetsuya Tanino, Mijung Kim, Akira Matsuda, Jiyong Hong, Satoshi Ichikawa, and Seok-Yong Lee. “Structural insights into inhibition of lipid I production in bacterial cell wall synthesis.” Nature 533, no. 7604 (May 26, 2016): 557–60. https://doi.org/10.1038/nature17636.
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  - Kwon, Do-Yeon, Hye Eun Lee, Douglas H. Weitzel, Kyunghye Park, Sun Hee Lee, Chen-Ting Lee, Tesia N. Stephenson, et al. “Synthesis and Biological Evaluation of Manassantin Analogues for Hypoxia-Inducible Factor 1α Inhibition.” J Med Chem 58, no. 19 (October 8, 2015): 7659–71. https://doi.org/10.1021/acs.jmedchem.5b01220.
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  - Baker, Joseph B., Hyoungsu Kim, and Jiyong Hong. “Total Synthesis of Clavosolide A via Tandem Allylic Oxidation/Oxa-Conjugate Addition Reaction.” Tetrahedron Letters 56, no. 23 (June 2015): 3120–22. https://doi.org/10.1016/j.tetlet.2014.11.135.
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  - Lim, Wonchung, Joonwoo Park, Yong Hee Lee, Jiyong Hong, and YoungJoo Lee. “Subglutinol A, an immunosuppressive α-pyrone diterpenoid from Fusarium subglutinans, acts as an estrogen receptor antagonist.” Biochemical and Biophysical Research Communications 461, no. 3 (June 2015): 507–12. https://doi.org/10.1016/j.bbrc.2015.04.053.
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  - Kim, Bumki, and Jiyong Hong. “An overview of naturally occurring histone deacetylase inhibitors.” Current Topics in Medicinal Chemistry 14, no. 24 (January 2015): 2759–82. https://doi.org/10.2174/1568026615666141208105614.
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  - Hong, Jiyong. “Natural product synthesis at the interface of chemistry and biology.” Chemistry (Weinheim an Der Bergstrasse, Germany) 20, no. 33 (August 2014): 10204–12. https://doi.org/10.1002/chem.201402804.
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  - Kim, Bumki, Heekwang Park, Lilibeth A. Salvador, Patrick E. Serrano, Jason C. Kwan, Sabrina L. Zeller, Qi-Yin Chen, et al. “Evaluation of class I HDAC isoform selectivity of largazole analogues.” Bioorganic & Medicinal Chemistry Letters 24, no. 16 (August 2014): 3728–31. https://doi.org/10.1016/j.bmcl.2014.07.006.
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  - Salvador, Lilibeth A., Heekwang Park, Fatma H. Al-Awadhi, Yanxia Liu, Bumki Kim, Sabrina L. Zeller, Qi-Yin Chen, Jiyong Hong, and Hendrik Luesch. “Modulation of Activity Profiles for Largazole-Based HDAC Inhibitors through Alteration of Prodrug Properties.” Acs Medicinal Chemistry Letters 5, no. 8 (August 2014): 905–10. https://doi.org/10.1021/ml500170r.
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  - Johnson, Zachary Lee, Jun-Ho Lee, Kiyoun Lee, Minhee Lee, Do-Yeon Kwon, Jiyong Hong, and Seok-Yong Lee. “Structural basis of nucleoside and nucleoside drug selectivity by concentrative nucleoside transporters.” Elife 3 (July 31, 2014). https://doi.org/10.7554/eLife.03604.
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  - Johnson, Zachary Lee, Jun-Ho Lee, Kiyoun Lee, Minhee Lee, Do-Yeon Kwon, Jiyong Hong, and Seok-Yong Lee. “Structural basis of nucleoside and nucleoside drug selectivity by concentrative nucleoside transporters.” Elife 3 (July 31, 2014): e03604. https://doi.org/10.7554/eLife.03604.
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  - Lin, Regina, Hyoungsu Kim, Jiyong Hong, and Qi-Jing Li. “Biological evaluation of subglutinol a as a novel immunosuppressive agent for inflammation intervention.” Acs Med Chem Lett 5, no. 5 (May 8, 2014): 485–90. https://doi.org/10.1021/ml4004809.
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  - Lanier, Megan L., Amanda C. Kasper, Hyoungsu Kim, and Jiyong Hong. “Synthesis of α,α'-trans-oxepanes through an organocatalytic oxa-conjugate addition reaction.” Organic Letters 16, no. 9 (May 2014): 2406–9. https://doi.org/10.1021/ol500773w.
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  - Yu, Mingming, Lilibeth A. Salvador, Sherwin K. B. Sy, Yufei Tang, Ravi S. P. Singh, Qi-Yin Chen, Yanxia Liu, Jiyong Hong, Hartmut Derendorf, and Hendrik Luesch. “Largazole pharmacokinetics in rats by LC-MS/MS.” Marine Drugs 12, no. 3 (March 2014): 1623–40. https://doi.org/10.3390/md12031623.
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  - Strickland, Erin C., M Ariel Geer, Jiyong Hong, and Michael C. Fitzgerald. “False-positive rate determination of protein target discovery using a covalent modification- and mass spectrometry-based proteomics platform.” Journal of the American Society for Mass Spectrometry 25, no. 1 (January 2014): 132–40. https://doi.org/10.1007/s13361-013-0754-2.
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  - Chung, Ben C., Jinshi Zhao, Robert A. Gillespie, Do-Yeon Kwon, Ziqiang Guan, Jiyong Hong, Pei Zhou, and Seok-Yong Lee. “Crystal structure of MraY, an essential membrane enzyme for bacterial cell wall synthesis.” Science 341, no. 6149 (August 30, 2013): 1012–16. https://doi.org/10.1126/science.1236501.
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  - Law, M. E., P. E. Corsino, S. C. Jahn, B. J. Davis, S. Chen, B. Patel, K. Pham, et al. “Glucocorticoids and histone deacetylase inhibitors cooperate to block the invasiveness of basal-like breast cancer cells through novel mechanisms.” Oncogene 32, no. 10 (March 2013): 1316–29. https://doi.org/10.1038/onc.2012.138.
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  - Chung, B. C., J. Zhao, R. A. Gillespie, D. Y. Kwon, Z. Guan, J. Hong, P. Zhou, and S. Y. Lee. “Crystal structure of MraY, an essential membrane enzyme for bacterial cell wall synthesis.” Science 341, no. 6149 (2013): 1012–16. https://doi.org/10.1126/science.1240985.
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  - Kaoud, Tamer S., Heekwang Park, Shreya Mitra, Chunli Yan, Chun-Chia Tseng, Yue Shi, Jiney Jose, et al. “Manipulating JNK signaling with (--)-zuonin A.” Acs Chemical Biology 7, no. 11 (November 2012): 1873–83. https://doi.org/10.1021/cb300261e.
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  - Kaoud, Tamer S., Chunli Yan, Shreya Mitra, Chun-Chia Tseng, Jiney Jose, Juliana M. Taliaferro, Maidina Tuohetahuntila, et al. “From in Silico Discovery to intra-Cellular Activity: Targeting JNK-Protein Interactions with Small Molecules.” Acs Medicinal Chemistry Letters 3, no. 9 (August 2012): 721–25. https://doi.org/10.1021/ml300129b.
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  - Lee, Kiyoun, Hyoungsu Kim, and Jiyong Hong. “N-Heterocyclic carbene catalyzed oxidative macrolactonization: total synthesis of (+)-dactylolide.” Angewandte Chemie (International Ed. in English) 51, no. 23 (June 2012): 5735–38. https://doi.org/10.1002/anie.201201653.
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  - Hong, Jiyong, and Hendrik Luesch. “Largazole: from discovery to broad-spectrum therapy.” Natural Product Reports 29, no. 4 (April 2012): 449–56. https://doi.org/10.1039/c2np00066k.
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  - Lee, Won-Gil, Woo-Seok Kim, Sung-Gyoo Park, Hyoungsu Kim, Jiyong Hong, Hyojin Ko, and Yong-Chul Kim. “Immunosuppressive effects of subglutinol derivatives.” Chemmedchem 7, no. 2 (February 2012): 218–22. https://doi.org/10.1002/cmdc.201100409.
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  - Byeon, Seong Rim, Heekwang Park, Hyoungsu Kim, and Jiyong Hong. “Stereoselective synthesis of 2,6-trans-tetrahydropyran via primary diamine-catalyzed oxa-conjugate addition reaction of α,β-unsaturated ketone: total synthesis of psymberin.” Organic Letters 13, no. 21 (November 2011): 5816–19. https://doi.org/10.1021/ol2024289.
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  - Park, Heekwang, Hyoungsu Kim, and Jiyong Hong. “A formal synthesis of SCH 351448.” Organic Letters 13, no. 14 (July 2011): 3742–45. https://doi.org/10.1021/ol201426c.
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  - Hong, Jiyong. “Role of natural product diversity in chemical biology.” Current Opinion in Chemical Biology 15, no. 3 (June 2011): 350–54. https://doi.org/10.1016/j.cbpa.2011.03.004.
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  - Harrington, James M., Heekwang Park, Yongcheng Ying, Jiyong Hong, and Alvin L. Crumbliss. “Characterization of Fe(III) sequestration by an analog of the cytotoxic siderophore brasilibactin A: implications for the iron transport mechanism in mycobacteria.” Metallomics : Integrated Biometal Science 3, no. 5 (May 2011): 464–71. https://doi.org/10.1039/c0mt00109k.
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  - Lee, Kiyoun, Hyoungsu Kim, and Jiyong Hong. “A stereoselective formal synthesis of leucascandrolide A.” Organic Letters 13, no. 10 (May 2011): 2722–25. https://doi.org/10.1021/ol200824r.
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  - Ying, Yongcheng, Hyoungsu Kim, and Jiyong Hong. “Stereoselective synthesis of 2,6-cis- and 2,6-trans-piperidines through organocatalytic aza-Michael reactions: a facile synthesis of (+)-myrtine and (-)-epimyrtine.” Organic Letters 13, no. 4 (February 2011): 796–99. https://doi.org/10.1021/ol103064f.
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  - Lee, K., H. Kim, and J. Hong. “Stereoselective Synthesis of Tetrahydropyrans via Tandem and Organocatalytic Oxa-Michael Reactions: Synthesis of the Tetrahydropyran Cores of ent-(+)-Sorangicin A (Accepted).” Eur. J. Org. Chem., 2011.
  - Lee, S. U., H. B. Kwak, S. H. Pi, H. K. You, S. Byeon, Y. Ying, H. Luesch, J. Hong, and S. H. Kim. “In Vitro and In Vivo Osteogenic Activity of Largazole.” Acs Med. Chem. Lett., no. 2 (2011): 248–51.
  - Kim, H., S. R. Byeon, M. G. D. Leed, and J. Hong. “. Intramolecular Michael Reactions of Aliphatic Aldehyde Enolates Generated by Imidazolium Carbenes.” Tetrahedron Lett., no. 52 (2011): 2468–70.
  - Liu, Yanxia, Lilibeth A. Salvador, Seongrim Byeon, Yongcheng Ying, Jason C. Kwan, Brian K. Law, Jiyong Hong, and Hendrik Luesch. “Anticolon cancer activity of largazole, a marine-derived tunable histone deacetylase inhibitor.” The Journal of Pharmacology and Experimental Therapeutics 335, no. 2 (November 2010): 351–61. https://doi.org/10.1124/jpet.110.172387.
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  - Kim, Hyoungsu, Joseph B. Baker, Yongho Park, Hyung-Bae Park, Patrick D. DeArmond, Seong Hwan Kim, Michael C. Fitzgerald, Dong-Sup Lee, and Jiyong Hong. “Total synthesis, assignment of the absolute stereochemistry, and structure-activity relationship studies of subglutinols A and B.” Chemistry, an Asian Journal 5, no. 8 (August 2010): 1902–10. https://doi.org/10.1002/asia.201000147.
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  - Kim, Hyoungsu, and Jiyong Hong. “Total synthesis of cyanolide A and confirmation of its absolute configuration.” Organic Letters 12, no. 12 (June 2010): 2880–83. https://doi.org/10.1021/ol101022z.
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  - Lee, Kiyoun, Hyoungsu Kim, and Jiyong Hong. “A facile and efficient synthesis of 4-hydroxy-2,6-cis-tetrahydropyrans via tandem cross-metathesis/thermal S(N)2' reaction: protecting-group-free synthesis of (+/-)-diospongin A.” Organic Letters 11, no. 22 (November 2009): 5202–5. https://doi.org/10.1021/ol902125d.
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  - Yuan, Langtian, Jin-Soo Seo, Nam Sook Kang, Shahar Keinan, Sarah E. Steele, Gregory A. Michelotti, William C. Wetsel, et al. “Identification of 3-hydroxy-2-(3-hydroxyphenyl)-4H-1-benzopyran-4-ones as isoform-selective PKC-zeta inhibitors and potential therapeutics for psychostimulant abuse.” Mol Biosyst 5, no. 9 (September 2009): 927–30. https://doi.org/10.1039/b903036k.
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  - Kasper, Amanda C., Eui Jung Moon, Xiangqian Hu, Yongho Park, Ceshea M. Wooten, Hyoungsu Kim, Weitao Yang, Mark W. Dewhirst, and Jiyong Hong. “Analysis of HIF-1 inhibition by manassantin A and analogues with modified tetrahydrofuran configurations.” Bioorg Med Chem Lett 19, no. 14 (July 15, 2009): 3783–86. https://doi.org/10.1016/j.bmcl.2009.04.071.
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  - Kasper, Amanda C., Joseph B. Baker, Hyoungsu Kim, and Jiyong Hong. “The end game of chemical genetics: target identification.” Future Medicinal Chemistry 1, no. 4 (July 2009): 727–36. https://doi.org/10.4155/fmc.09.52.
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  - Kim, H., A. C. Kasper, E. J. Moon, Y. Park, C. M. Wooten, M. W. Dewhirst, and J. Hong. “Nucleophilic Addition of Organozinc Reagents to 2-Sulfonyl Cyclic Ethers: Stereoselective Synthesis of Manassantins A and B (Org. Lett., (2009) 11:7 (1671-1671).” Organic Letters 11, no. 7 (April 2, 2009): 1671. https://doi.org/10.1021/ol900421x.
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  - Lee, Jongkook, Jiyong Hong, Tae-Gyu Nam, Eric C. Peters, Anthony P. Orth, Bernhard H. Geierstanger, Lawrence E. Goldfinger, Mark H. Ginsberg, Charles Y. Cho, and Peter G. Schultz. “A small molecule inhibitor of alpha4 integrin-dependent cell migration.” Bioorganic & Medicinal Chemistry 17, no. 3 (February 2009): 977–80. https://doi.org/10.1016/j.bmc.2008.02.067.
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  - Kim, H., J. B. Baker, S. U. Lee, Y. Park, K. L. Bolduc, H. B. Park, M. G. Dickens, et al. “Stereoselective synthesis and osteogenic activity of subglutinols A and B.” Journal of the American Chemical Society 131, no. 9 (2009): 3192–94.
  - Kim, Hyoungsu, Amanda C. Kasper, Eui Jung Moon, Yongho Park, Ceshea M. Wooten, Mark W. Dewhirst, and Jiyong Hong. “Nucleophilic addition of organozinc reagents to 2-sulfonyl cyclic ethers: stereoselective synthesis of manassantins A and B.” Org Lett 11, no. 1 (January 1, 2009): 89–92. https://doi.org/10.1021/ol8024617.
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  - Kim, Hyoungsu, Yongho Park, and Jiyong Hong. “Stereoselective synthesis of 2,6-cis-tetrahydropyrans through a tandem allylic oxidation/oxa-Michael reaction promoted by the gem-disubstituent effect: synthesis of (+)-neopeltolide macrolactone.” Angewandte Chemie (International Ed. in English) 48, no. 41 (January 2009): 7577–81. https://doi.org/10.1002/anie.200903690.
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  - Ying, Yongcheng, Kanchan Taori, Hyoungsu Kim, Jiyong Hong, and Hendrik Luesch. “Total synthesis and molecular target of largazole, a histone deacetylase inhibitor.” Journal of the American Chemical Society 130, no. 26 (July 2008): 8455–59. https://doi.org/10.1021/ja8013727.
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  - Kim, D., H. Lee, K. W. Kim, J. Park, H. Kim, S. Kim, X. Hu, W. Yang, and J. Hong. “A general strategy for construction of both 2,6-cis- and 2,6-trans-disubstituted tetrahydropyrans: substrate-controlled asymmetric total synthesis of (+)-scanlonenyne.” Angewandte Chemie International Edition 47, no. 22 (2008): 4200–4203.
  - Ying, Y., Y. Liu, S. R. Byeon, H. Kim, H. Luesch, and J. Hong. “Synthesis and activity of largazole analogues with linker and macrocycle modification.” Organic Letters 10, no. 18 (2008): 4021–24.
  - Ying, Y., and J. Hong. “Synthesis of brasilibactin A and confirmation of absolute configuration of β-hydroxy acid fragment.” Tetrahedron Letters 48, no. 46 (November 12, 2007): 8104–7. https://doi.org/10.1016/j.tetlet.2007.09.112.
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  - Lee, Jongkook, Xu Wu, Marina Pasca di Magliano, Eric C. Peters, Yan Wang, Jiyong Hong, Metthias Hebrok, Sheng Ding, Charles Y. Cho, and Peter G. Schultz. “A small-molecule antagonist of the hedgehog signaling pathway.” Chembiochem : A European Journal of Chemical Biology 8, no. 16 (November 2007): 1916–19. https://doi.org/10.1002/cbic.200700403.
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  - Kim, Hyoungsu, Ceshea M. Wooten, Yongho Park, and Jiyong Hong. “Stereoselective synthesis of tetrahydrofuran lignans via BF(3) x OEt(2)-promoted reductive deoxygenation/epimerization of cyclic hemiketal: synthesis of (-)-odoratisol C, (-)-futokadsurin A, (-)-veraguensin, (+)-fragransin A(2), (+)-galbelgin, and (+)-talaumidin.” Organic Letters 9, no. 20 (September 2007): 3965–68. https://doi.org/10.1021/ol7016388.
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  - Hong, J., J. Lee, K. H. Min, J. R. Walker, E. C. Peters, N. S. Gray, C. Y. Cho, and P. G. Schultz. “Identification and characterization of small molecule inducers of epidermal keratinocyte differentiation.” American Chemical Society Chemical Biology 2 (2007): 171–75.
  - Collins, Cynthia S., Jiyong Hong, Lisa Sapinoso, Yingyao Zhou, Zheng Liu, Kenneth Micklash, Peter G. Schultz, and Garret M. Hampton. “A small interfering RNA screen for modulators of tumor cell motility identifies MAP4K4 as a promigratory kinase.” Proceedings of the National Academy of Sciences of the United States of America 103, no. 10 (March 2006): 3775–80. https://doi.org/10.1073/pnas.0600040103.
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  - Lee, Jongkook, and Jiyong Hong. “First synthesis and structural elucidation of (-)-presphaerene.” The Journal of Organic Chemistry 69, no. 19 (September 2004): 6433–40. https://doi.org/10.1021/jo049351c.
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  - Boger, D. L., and J. Hong. “Asymmetric total synthesis of ent-(-)-roseophilin: assignment of absolute configuration.” Journal of the American Chemical Society 123, no. 35 (September 2001): 8515–19. https://doi.org/10.1021/ja011271s.
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  - Boger, D. L., J. Hong, M. Hikota, and M. Ishida. “Total synthesis of phomazarin.” Journal of the American Chemical Society 121, no. 11 (March 24, 1999): 2471–77. https://doi.org/10.1021/ja983631q.
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  - Boger, D. L., and J. Hong. “Total synthesis of nothapodytine b and (-)-mappicine.” Journal of the American Chemical Society 120, no. 6 (February 18, 1998): 1218–22. https://doi.org/10.1021/ja973007y.
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  - Kim, D., W. J. Choi, J. Y. Hong, Y. Park, and Y. B. Kim. “An asymmetric synthesis of (+)-isonitramine by 'triple allylic strain-controlled' intramolecular SN2' alkylation.” Tetrahedron Letters 37, no. 9 (February 26, 1996): 1433–34. https://doi.org/10.1016/0040-4039(96)00023-8.
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- Book Sections
  - Weintraub, E. R. “Preface.” In Stabilizing Dynamics: Constructing Economic Knowledge (Japanese Edition). Tokyo: Bunka-Shobo Hakubun-sha Publishing, Ltd, 1994.
- Conference Papers
  - Lee, Hyunji, and Jiyong Hong. “Design and synthesis of a natural product-like macrocycle library containing tetrahydropyran moieties.” In Abstracts of Papers of the American Chemical Society, Vol. 256. AMER CHEMICAL SOC, 2018.
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  - Lee, Minhee, Jinshi Zhao, Jae Cho, Do-Yeon Kwon, Pei Zhou, and Jiyong Hong. “Synthesis and biological evaluation of sulfonyl piperazine derivatives for LpxH inhibition.” In Abstracts of Papers of the American Chemical Society, Vol. 253. AMER CHEMICAL SOC, 2017.
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  - Park, Hyeri, Megan Lanier, Paramita Mukherjee, Anthony Ribeiro, Ross Widenhoefer, and Jiyong Hong. “Exploration of gold(I)-catalyzed alkoxylation for formal synthesis of (+)-laurencin.” In Abstracts of Papers of the American Chemical Society, Vol. 253. AMER CHEMICAL SOC, 2017.
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  - Kwon, Do-Yeon, Kyunghye Park, Douglas Weitzel, Sun Hee Lee, Tesia Stephenson, Chen-Ting Lee, Jen-Tsan Chi, et al. “Design, synthesis, and biological evaluation of manassantin analogues for HIF-1 alpha inhibition.” In Abstracts of Papers of the American Chemical Society, Vol. 249. AMER CHEMICAL SOC, 2015.
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  - Lanier, Megan L., Amanda C. Kasper, Hyoungsu Kim, and Jiyong Hong. “Stereoselective synthesis of alpha,alpha '-trans-oxepanes through an organocatalytic oxa-conjugate addition reaction.” In Abstracts of Papers of the American Chemical Society, Vol. 247. AMER CHEMICAL SOC, 2014.
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  - Chung, Ben C., Jinshi Zhao, Robert Gillespie, Do Yeon Kwon, Ziqiang Guan, Jiyong Hong, Pei Zhou, and Seok-Yong Lee. “Crystal Structure of MraY, an Essential Membrane Enzyme for Bacterial Cell Wall Synthesis.” In Biophysical Journal, 106:14a-14a. Elsevier BV, 2014. https://doi.org/10.1016/j.bpj.2013.11.131.
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  - Lee, Kiyoun, Hyoungsu Kim, and Jiyong Hong. “Stereoselective formal synthesis of leucascandrolide A.” In Abstracts of Papers of the American Chemical Society, Vol. 242. AMER CHEMICAL SOC, 2011.
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  - Ying, Yongcheng, Hyoungsu Kim, and Jiyong Hong. “Efficient and stereoselective synthesis of 2,6-disubstituted piperidines through an organocatalytic aza-Michael reaction promoted by the gem-disubstituent effect.” In Abstracts of Papers of the American Chemical Society, Vol. 239. AMER CHEMICAL SOC, 2010.
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  - Harrington, James M., Heekwang Park, Yongcheng Ying, Jiyong Hong, and Alvin L. Crumbliss. “Thermodynamic characterization of iron(III) and zinc binding by Brasilibactin A.” In Abstracts of Papers of the American Chemical Society, Vol. 238. AMER CHEMICAL SOC, 2009.
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  - Ying, Yongcheng, Hyoungsu Kim, Kanchan Taori, Hendrik Luesch, and Jiyong Hong. “ORGN 523-Total synthesis of largazole.” In Abstracts of Papers of the American Chemical Society, Vol. 236. AMER CHEMICAL SOC, 2008.
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Teaching & Mentoring
Recent Courses
- CHEM 393: Research Independent Study 2023
- CHEM 394: Research Independent Study 2023
- CHEM 493: Research Independent Study 2023
- CHEM 494: Research Independent Study 2023
- CHEM 393: Research Independent Study 2022
- CHEM 394: Research Independent Study 2022
- CHEM 493: Research Independent Study 2022
- CHEM 494: Research Independent Study 2022
- CHEM 518: Chemical Biology 2022
- CHEM 532: Organic Reactions 2022
- CHEM 393: Research Independent Study 2021
- CHEM 394: Research Independent Study 2021
- CHEM 493: Research Independent Study 2021
- CHEM 494: Research Independent Study 2021
Scholarly, Clinical, & Service Activities
Presentations & Appearances
Service to the Profession
- Editorial Board Member : Archives of Pharmacal Research. 2013 2013
- Editorial Board, Archives of Pharmacal Research, Springer. December 6, 2011 2011

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