Joel Collier

Journal article Sci Adv · July 22, 2022 Featured Publication Subunit vaccines inducing antibodies against tumor-specific antigens have yet to be clinically successful. Here, we use a supramolecular α-helical peptide nanofiber approach to design epitope-specific vaccines raising simultaneous B cell, CD8+ T cell, and ... Full text Link to item Cite

HIV envelope antigen valency on peptide nanofibers modulates antibody magnitude and binding breadth.

Journal article Sci Rep · July 14, 2021 Featured Publication A major challenge in developing an effective vaccine against HIV-1 is the genetic diversity of its viral envelope. Because of the broad range of sequences exhibited by HIV-1 strains, protective antibodies must be able to bind and neutralize a widely mutate ... Full text Link to item Cite

Randomized peptide assemblies for enhancing immune responses to nanomaterials.

Journal article Biomaterials · June 2021 Featured Publication Biomaterials capable of inducing immune responses with minimal associated inflammation are of interest in applications ranging from tissue repair to vaccines. Here we report the design of self-assembling randomized polypeptide nanomaterials inspired by gla ... Full text Cite

Advances in nanomaterial vaccine strategies to address infectious diseases impacting global health.

Journal article Nature nanotechnology · April 2021 Featured Publication Despite the overwhelming success of vaccines in preventing infectious diseases, there remain numerous globally devastating diseases without fully protective vaccines, particularly human immunodeficiency virus (HIV), malaria and tuberculosis. Nanotechnology ... Full text Cite

Modular complement assemblies for mitigating inflammatory conditions.

Journal article Proceedings of the National Academy of Sciences of the United States of America · April 2021 Featured Publication Complement protein C3dg, a key linkage between innate and adaptive immunity, is capable of stimulating both humoral and cell-mediated immune responses, leading to considerable interest in its use as a molecular adjuvant. However, the potential of C3dg as a ... Full text Cite

Tabletized Supramolecular Assemblies for Sublingual Peptide Immunization.

Journal article Advanced healthcare materials · March 2021 Featured Publication Widespread vaccination is essential to global health. Significant barriers exist to improving vaccine coverage in lower- and middle-income countries, including the costly requirements for cold-chain distribution and trained medical personnel to administer ... Full text Cite

Controlled Lengthwise Assembly of Helical Peptide Nanofibers to Modulate CD8⁺ T-Cell Responses.

Journal article Advanced materials (Deerfield Beach, Fla.) · October 2020 Featured Publication Peptide nanofibers are useful for many biological applications, including immunotherapy, tissue engineering, and drug delivery. The robust lengthwise assembly of these peptides into nanofibers is typically difficult to control, resulting in polydisperse fi ... Full text Cite

Comparative study of α-helical and β-sheet self-assembled peptide nanofiber vaccine platforms: influence of integrated T-cell epitopes.

Journal article Biomater Sci · June 21, 2020 Featured Publication Several different self-assembling peptide systems that form nanofibers have been investigated as vaccine platforms, but design principles for adjusting the character of the immune responses they raise have yet to be well articulated. Here we compared the i ... Full text Link to item Cite

Enabling sublingual peptide immunization with molecular self-assemblies.

Journal article Biomaterials · May 2020 Featured Publication Short peptides are poorly immunogenic when delivered sublingually - under the tongue. Nanomaterial delivery of peptides could be utilized to improve immunogenicity towards designed sublingual vaccines, but nanomaterials have not been widely successful in s ... Full text Cite

Multifactorial Design of a Supramolecular Peptide Anti-IL-17 Vaccine Toward the Treatment of Psoriasis.

Journal article Frontiers in immunology · January 2020 Featured Publication Current treatments for chronic immune-mediated diseases such as psoriasis, rheumatoid arthritis, or Crohn's disease commonly rely on cytokine neutralization using monoclonal antibodies; however, such approaches have drawbacks. Frequent repeated dosing can ... Full text Cite

Long-Term Evaluation of AAV-CRISPR Genome Editing for Duchenne Muscular Dystrophy

Conference MOLECULAR THERAPY · April 22, 2019 Featured Publication Link to item Cite

Intranasal delivery of adjuvant-free peptide nanofibers elicits resident CD8⁺ T cell responses.

Journal article Journal of controlled release : official journal of the Controlled Release Society · July 2018 Featured Publication Influenza vaccines that can be administered intranasally or by other needle-free delivery routes have potential advantages over injected formulations in terms of patient compliance, cost, and ease of global distribution. Supramolecular peptide nanofibers h ... Full text Cite

Progress Toward the Clinical Translation of Bioinspired Peptide and Protein Assemblies.

Journal article Advanced healthcare materials · March 2018 Featured Publication Supramolecular materials composed of proteins and peptides have been receiving considerable attention toward a range of diseases and conditions from vaccines to drug delivery. Owing to the relative newness of this class of materials, the bulk of work to da ... Full text Cite

MyD88 in antigen-presenting cells is not required for CD4+ T-cell responses during peptide nanofiber vaccination.

Journal article MedChemComm · January 2018 Featured Publication Self-assembled peptide nanofibers raise significant antibody and T cell responses without adjuvants, but the mechanism by which they achieve this has not been fully elucidated. Myeloid differentiation primary response gene 88 (MyD88) previously has been sh ... Full text Cite

Practical Considerations in the Design and Use of Immunologically Active Fibrillar Peptide Assemblies.

Journal article Methods in molecular biology (Clifton, N.J.) · January 2018 Featured Publication The design, formulation, and immunological evaluation of self-assembling peptide materials is relatively straightforward. Indeed, one of the advantages of synthetic self-assembling peptides is that one can progress from initial concept to in vivo testing i ... Full text Cite

A Supramolecular Vaccine Platform Based on α-Helical Peptide Nanofibers.

Journal article ACS Biomater Sci Eng · December 11, 2017 Featured Publication A supramolecular peptide vaccine system was designed in which epitope-bearing peptides self-assemble into elongated nanofibers composed almost entirely of alpha-helical structure. The nanofibers were readily internalized by antigen presenting cells and pro ... Full text Link to item Cite

Active immunotherapy for TNF-mediated inflammation using self-assembled peptide nanofibers.

Journal article Biomaterials · December 2017 Featured Publication Active immunotherapies raising antibody responses against autologous targets are receiving increasing interest as alternatives to the administration of manufactured antibodies. The challenge in such an approach is generating protective and adjustable level ... Full text Cite

Biomaterial strategies for generating therapeutic immune responses.

Journal article Advanced drug delivery reviews · May 2017 Featured Publication Biomaterials employed to raise therapeutic immune responses have become a complex and active field. Historically, vaccines have been developed primarily to fight infectious diseases, but recent years have seen the development of immunologically active biom ... Full text Cite

α-Helical coiled-coil peptide materials for biomedical applications.

Journal article Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · March 2017 Featured Publication Self-assembling coiled coils, which occur commonly in native proteins, have received significant interest for the design of new biomaterials-based medical therapies. Considerable effort over recent years has led to a detailed understanding of the self-asse ... Full text Cite

Switching the Immunogenicity of Peptide Assemblies Using Surface Properties.

Journal article ACS nano · October 2016 Featured Publication Biomaterials created from supramolecular peptides, proteins, and their derivatives have been receiving increasing interest for both immunological applications, such as vaccines and immunotherapies, as well as ostensibly nonimmunological applications, such ... Full text Cite

This paper is the winner of an SFB Award in the Hospital Intern, Residency category: Peptide biomaterials raising adaptive immune responses in wound healing contexts.

Journal article Journal of biomedical materials research. Part A · August 2016 Featured Publication Biomaterials used in the context of tissue engineering or wound repair are commonly designed to be "nonimmunogenic." However, previously it has been observed that self-assembled peptide nanofiber materials are noninflammatory despite their immunogenicity, ... Full text Cite

Thermal stability of self-assembled peptide vaccine materials.

Journal article Acta biomaterialia · January 2016 Featured Publication The majority of current vaccines depend on a continuous "cold chain" of storage and handling between 2 and 8°C. Vaccines experiencing temperature excursions outside this range can suffer from reduced potency. This thermal sensitivity results in significant ... Full text Cite

Supramolecular peptide vaccines: tuning adaptive immunity.

Journal article Current opinion in immunology · August 2015 Featured Publication Successful immunotherapies must be designed to elicit targeted immune responses having a specifiable phenotype across many dimensions, including the phenotypes of T cells, B cells, antigen-presenting cells, and others. For synthetic or subunit vaccines, st ... Full text Cite

Titrating T-cell epitopes within self-assembled vaccines optimizes CD4+ helper T cell and antibody outputs.

Journal article Advanced healthcare materials · November 2014 Featured Publication Epitope content plays a critical role in determining T-cell and antibody responses to vaccines, biomaterials, and protein therapeutics, but its effects are nonlinear and difficult to isolate. Here, molecular self-assembly is used to build a vaccine with pr ... Full text Cite

Gradated assembly of multiple proteins into supramolecular nanomaterials.

Journal article Nature materials · August 2014 Featured Publication Biomaterials exhibiting precise ratios of different bioactive protein components are critical for applications ranging from vaccines to regenerative medicine, but their design is often hindered by limited choices and cross-reactivity of protein conjugation ... Full text Cite

Engaging adaptive immunity with biomaterials.

Journal article Journal of materials chemistry. B · May 2014 Featured Publication Adaptive immune responses, characterized by T cells and B cells engaging and responding to specific antigens, can be raised by biomaterials containing proteins, peptides, and other biomolecules. How does one avoid, control, or exploit such responses? This ... Full text Cite

The use of self-adjuvanting nanofiber vaccines to elicit high-affinity B cell responses to peptide antigens without inflammation.

Journal article Biomaterials · November 2013 Featured Publication Balancing immunogenicity with inflammation is a central tenet of vaccine design, especially for subunit vaccines that utilize traditional pro-inflammatory adjuvants. Here we report that by using a nanoparticulate peptide-based vaccine, immunogenicity and l ... Full text Cite

Controllably degradable β-sheet nanofibers and gels from self-assembling depsipeptides.

Journal article Biomaterials science · October 2013 Featured Publication Self-assembled peptide materials have received considerable interest for a range of applications, including 3D cell culture, tissue engineering, and the delivery of cells and drugs. One challenge in applying such materials within these areas has been the e ... Full text Cite

A self-adjuvanting supramolecular vaccine carrying a folded protein antigen.

Journal article Advanced healthcare materials · August 2013 Featured Publication This work illustrates a strategy for the design of molecularly defined immunotherapies, using a blend of supramolecular peptide self-assembly and active site-directed protein capture. ... Full text Cite

Multifactorial optimization of endothelial cell growth using modular synthetic extracellular matrices.

Journal article Integrative biology : quantitative biosciences from nano to macro · March 2011 Featured Publication Extracellular matrices (ECMs) are complex materials, containing at least dozens of different macromolecules that are assembled together, thus complicating their optimization towards applications in 3D cell culture or tissue engineering. The natural complex ... Full text Cite

A self-assembling peptide acting as an immune adjuvant.

Journal article Proceedings of the National Academy of Sciences of the United States of America · January 2010 Featured Publication The development of vaccines and other immunotherapies has been complicated by heterogeneous antigen display and the use of incompletely defined immune adjuvants with complex mechanisms of action. We have observed strong antibody responses in mice without t ... Full text Cite