Scholars@Duke
Joel Meyer

Joel Meyer

Sally Kleberg Distinguished Professorship
Environmental Natural Science
Box 90328, Durham, NC 27708-0328
A354 Lev Sci Res Ctr, Durham, NC 27708

Featured Works

Genetic Defects in Mitochondrial Dynamics in Caenorhabditis elegans Impact Ultraviolet C Radiation- and 6-hydroxydopamine-Induced Neurodegeneration.

Journal article International journal of molecular sciences · June 2019 Featured Publication BackgroundParkinson's disease (PD) is one of the most common neurodegenerative disorders involving devastating loss of dopaminergic neurons in the substantia nigra. Early steps in PD pathogenesis include mitochondrial dysfunction, and mutations in ... Full text Cite

Swimming Exercise and Transient Food Deprivation in Caenorhabditis elegans Promote Mitochondrial Maintenance and Protect Against Chemical-Induced Mitotoxicity.

Journal article Scientific reports · May 2018 Featured Publication Exercise and caloric restriction improve health, including reducing risk of cardiovascular disease, neurological disease, and cancer. However, molecular mechanisms underlying these protections are poorly understood, partly due to the cost and time investme ... Full text Open Access Cite

Mitochondrial Toxicity.

Journal article Toxicological sciences : an official journal of the Society of Toxicology · March 2018 Featured Publication Recent decades have seen a rapid increase in reported toxic effects of drugs and pollutants on mitochondria. Researchers have also documented many genetic differences leading to mitochondrial diseases, currently reported to affect ∼1 person in 4,300, creat ... Full text Open Access Cite

The high-production volume fungicide pyraclostrobin induces triglyceride accumulation associated with mitochondrial dysfunction, and promotes adipocyte differentiation independent of PPARγ activation, in 3T3-L1 cells.

Journal article Toxicology · January 2018 Featured Publication Pyraclostrobin is one of the most heavily used fungicides, and has been detected on a variety of produce, suggesting human exposure occurs regularly. Recently, pyraclostrobin exposure has been linked to a variety of toxic effects, including neurodegenerati ... Full text Cite

Mitochondrial fusion, fission, and mitochondrial toxicity.

Journal article Toxicology · November 2017 Featured Publication Mitochondrial dynamics are regulated by two sets of opposed processes: mitochondrial fusion and fission, and mitochondrial biogenesis and degradation (including mitophagy), as well as processes such as intracellular transport. These processes maintain mito ... Full text Cite

Deficiencies in mitochondrial dynamics sensitize Caenorhabditis elegans to arsenite and other mitochondrial toxicants by reducing mitochondrial adaptability.

Journal article Toxicology · July 2017 Featured Publication Mitochondrial fission, fusion, and mitophagy are interlinked processes that regulate mitochondrial shape, number, and size, as well as metabolic activity and stress response. The fundamental importance of these processes is evident in the fact that mutatio ... Full text Cite