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Joel Meyer

Sally Kleberg Distinguished Professorship
Environmental Natural Science
Box 90328, Durham, NC 27708-0328
A354 Lev Sci Res Ctr, Durham, NC 27708

Scholarly Works - Preprints


Dopaminergic neuronal dysfunction induced by newer generation systemic insecticides in Caenorhabditis elegans

Preprint · 2026 Summary While a growing number of studies have linked environmental exposures and Parkinson’s disease (PD) 1–3 , the impact of many pesticides remains understudied 4,5 ; for example, neonicotinoids are the most used insecticides in the world, b ... Full text Cite

Specialized high-capacity mitochondria fuel cell invasion.

Preprint · May 3, 2025 Cell invasion through basement membrane (BM) is energetically intensive, and how an invading cell produces high ATP levels to power invasion is understudied. By generating 20 endogenously tagged mitochondrial proteins, we identified a specialized mitochond ... Full text Link to item Cite

Programmed mitophagy at the oocyte-to-zygote transition promotes species immortality.

Preprint · April 9, 2025 The quality of mitochondria inherited from the oocyte determines embryonic viability, metabolic health throughout progeny lifetime, and future generation endurance. High levels of endogenous reactive oxygen species and exogenous toxicants are threats to mi ... Full text Link to item Cite

Mitophagy at the oocyte-to-zygote transition promotes species immortality.

Preprint · February 3, 2025 The quality of inherited mitochondria determines embryonic viability 1 , metabolic health during adulthood and future generation endurance. The oocyte is the source of all zygotic mitochondria 2 , and mitochondrial health is under strict developmental regu ... Full text Link to item Cite

Chronic high-sugar diet in adulthood protects Caenorhabditis elegans from 6-OHDA induced dopaminergic neurodegeneration

Preprint · 2023 Background Diets high in saturated fat and sugar, termed ‘western diets’, have been associated with several negative health outcomes, including increased risk for neurodegenerative disease. Parkinson’s Disease (PD) is the second most prevalent ne ... Full text Cite

Bioenergetic function is decreased in peripheral blood mononuclear cells of veterans with Gulf War Illness

Preprint · 2023 Gulf War Illness (GWI) is a major health problem for approximately 250,000 Gulf War (GW) veterans, but the etiology of GWI is unclear. We hypothesized that mitochondrial dysfunction is an important contributor to GWI, based on the similarity of some GWI sy ... Full text Cite