John Stephen Ginn

External beam treatment planning for breast and lung cancer radiation therapy; Applications of MRI in radiation oncology; Machine learning for automatic segmentation and motion management during radiation therapy.

Current Appointments & Affiliations

Assistant Professor of Radiation Oncology · 2022 - Present Radiation Oncology, Clinical Science Departments

Member of the Duke Cancer Institute · 2023 - Present Duke Cancer Institute, Institutes and Centers

Recent Publications

Knowledge-based deep residual U-Net (DRU) for synthetic CT generation using a single MR volume for frameless radiosurgery.

Journal Article J Appl Clin Med Phys · January 2026 PURPOSE: To develop a knowledge-based deep model for sCT generation from a single MR volume in LINAC-based frameless SRS, enabling the MR-only workflow without extra CT simulation. METHODS: A total of 139 patients were included in the study, with 120 used ... Full text Link to item Cite

An Explainable Deep Model for Risk Scoring and Accurate Radionecrosis Identification Following Brain Metastasis Stereotactic Radiosurgery.

Conference Int J Radiat Oncol Biol Phys · November 27, 2025 PURPOSE: As survival improves for patients with brain metastases (BM), distinguishing local recurrence (LR) from radionecrosis (RN) is a growing neuro-oncologic challenge. We aimed to develop an explainable deep learning model to noninvasively distinguish ... Full text Link to item Cite

A Radiogenomic Deep Ensemble Learning Model for Identifying Radionecrosis Following Brain Metastases (BM) Stereotactic Radiosurgery in Patients With Non-small Cell Lung Cancer BM.

Journal Article Adv Radiat Oncol · August 2025 PURPOSE: Stereotactic radiosurgery (SRS) is widely used for brain metastases (BM), but the risk of radionecrosis poses a challenge in post-SRS management. Given the lack of noninvasive imaging methods for distinguishing radionecrosis from recurrence, we ai ... Full text Link to item Cite

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Education

University of California, Los Angeles · 2019 Ph.D.

University of California, Los Angeles · 2017 M.S.

Wheaton College · 2015 B.S.