Scholars@Duke
John Hunter Peel Alexander

John Hunter Peel Alexander

Professor of Medicine
Medicine, Cardiology
john.h.alexander@duke.edu
Duke Box 17969, Durham, NC 27715
300 W. Morgan Street, Durham, NC 27701

Featured Works

Effect of tenecteplase versus alteplase on platelets during the first 3 hours of treatment for acute myocardial infarction: the Assessment of the Safety and Efficacy of a New Thrombolytic Agent (ASSENT-2) platelet substudy.

Journal article Am Heart J · April 2003 Featured Publication BACKGROUND: Platelets play a pivotal role in the pathogenesis of acute myocardial infarction, as well as in the occurrence of coronary artery reocclusion and bleeding events. Therefore, the success of fibrinolytic therapy may be dependent on its direct eff ... Full text Link to item Cite

Minor myocardial damage and prognosis: are spontaneous and percutaneous coronary intervention-related events different?

Journal article Circulation · February 5, 2002 Featured Publication BACKGROUND: The relevance of the adverse prognostic implications of CK-MB elevation after percutaneous coronary intervention (PCI) remains controversial. Therefore, we compared the relationship between the level of postprocedural CK-MB elevation and 6-mont ... Full text Link to item Cite

Safety of the weight-adjusted dosing regimen of tenecteplase in the ASSENT-Trial.

Journal article Am J Cardiol · December 1, 2001 Featured Publication The results of the ASsessment of Safety and Efficacy of a New Thrombolytic agent (ASSENT-2) trial revealed that tenecteplase (TNK) is equivalent to tissue plasminogen activator (t-PA) for treating myocardial infarction. Because careful consideration of saf ... Full text Link to item Cite

Medicine. Placebo-controls in short-term clinical trials of hypertension.

Journal article Science · June 15, 2001 Featured Publication Full text Link to item Cite

Platelet function and fibrinolytic agents: two sides of a coin?

Journal article Cardiology · 2001 Featured Publication Fibrinolytic therapy is the established treatment for the management of patients with ST elevation acute myocardial infarction (AMI). Present fibrinolytic regimens have a number of shortcomings, including the failure to produce early and sustained reperfus ... Full text Link to item Cite

Association between minor elevations of creatine kinase-MB level and mortality in patients with acute coronary syndromes without ST-segment elevation. PURSUIT Steering Committee. Platelet Glycoprotein IIb/IIIa in Unstable Angina: Receptor Suppression Using Integrilin Therapy.

Journal article JAMA · January 19, 2000 Featured Publication CONTEXT: Controversy surrounds the diagnostic and prognostic importance of slightly elevated cardiac markers in patients with acute coronary syndromes without ST-segment elevation. OBJECTIVES: To investigate the relationship between peak creatine kinase (C ... Full text Link to item Cite

A protocol of early spiral computed tomography for the detection of stones in patients with renal colic has reduced the time to diagnosis and overall management costs.

Journal article Aust N Z J Surg · January 2000 Featured Publication BACKGROUND: The recent use of spiral computed tomography (CT) without contrast for the diagnosis of acute flank pain has been shown to be highly sensitive and specific for the detection of urolithiasis. This method has not, however, been evaluated for its ... Full text Link to item Cite

Gastropathy induced by nonsteroidal anti-inflammatory drugs: prescribing patterns among geriatric practitioners.

Journal article J Am Osteopath Assoc · June 1999 Featured Publication The objective of this study was to determine patterns among geriatric practitioners in prescribing agents that protect the gastrointestinal tract when nonsteroidal anti-inflammatory drug (NSAID) treatment is started for elderly patients. A questionnaire de ... Full text Link to item Cite

Prophylactic lidocaine use in acute myocardial infarction: incidence and outcomes from two international trials. The GUSTO-I and GUSTO-IIb Investigators.

Journal article Am Heart J · May 1999 Featured Publication BACKGROUND: Early meta-analyses suggested that prophylactic lidocaine use reduces ventricular fibrillation but increases mortality rates after acute myocardial infarction. We determined the frequency and effect on clinical outcomes with its use in the thro ... Full text Link to item Cite

Multicenter randomized trial and a systematic overview of lidocaine in acute myocardial infarction.

Journal article Am Heart J · May 1999 Featured Publication BACKGROUND: More than 20 randomized trials and 4 meta-analyses have been conducted on the use of prophylactic lidocaine in acute myocardial infarction (MI). The results suggest that lidocaine reduces ventricular fibrillation (VF) but increases mortality ra ... Full text Link to item Cite

Prior aspirin use predicts worse outcomes in patients with non-ST-elevation acute coronary syndromes. PURSUIT Investigators. Platelet IIb/IIIa in Unstable angina: Receptor Suppression Using Integrilin Therapy.

Journal article Am J Cardiol · April 15, 1999 Featured Publication Aspirin is beneficial in the prevention and treatment of cardiovascular events, but patients who have events while taking aspirin may have worse outcomes than those not on aspirin. We investigated the association between prior aspirin use and clinical outc ... Full text Link to item Cite

Recent antiplatelet drug trials in the acute coronary syndromes. Clinical interpretation of PRISM, PRISM-PLUS, PARAGON A and PURSUIT.

Journal article Drugs · December 1998 Featured Publication This paper reviews the results of 4 recent clinical trials, Platelet Receptor inhibition for Ischaemic Syndrome Management (PRISM), Platelet Receptor inhibition for Ischaemic Syndrome Management in Patients Limited to very Unstable Signs and symptoms (PRIS ... Full text Link to item Cite

Antiplatelet and antithrombin therapies in the acute coronary syndromes.

Journal article Curr Opin Cardiol · July 1997 Featured Publication The circulating platelet and the soluble coagulation protein thrombin play key roles in the thrombosis responsible for the acute coronary syndromes. The standard antiplatelet and antithrombin agents used today in patients with acute coronary syndromes are ... Link to item Cite

Adjunctive Antiplatelet Therapy in Acute Myocardial Infarction: The Road to Improved Infarct-Related Artery Patency.

Journal article J Thromb Thrombolysis · 1997 Featured Publication A direct relationship exists between infarct artery patency and survival in patients with acute myocardial infarction. Currently available thrombolytic regimens produce 90 minute patency rates on the order of 80%. Preliminary trials suggest that adjunctive ... Full text Link to item Cite