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John Wirthlin Hickey

Assistant Professor of Biomedical Engineering
Biomedical Engineering

Scholarly Works - Other


Figure S7 from Spatially Segregated Macrophage Populations Predict Distinct Outcomes in Colon Cancer

Other · June 17, 2026 <p>Thus Figure shows spatial enrichment of NLRP3+ macrophages with neutrophils in Crohn’s Disease, and immunostimulatory and immunosuppressive protein marker expression in NLRP3+ vs SPP1+ macrophages.</p> ... Full text Cite

Figure S3 from Spatially Segregated Macrophage Populations Predict Distinct Outcomes in Colon Cancer

Other · June 17, 2026 <p>Thus Figure shows CD274 gene scRNAseq expression across different cell types and datasets.</p> ... Full text Cite

Figure S9 from Spatially Segregated Macrophage Populations Predict Distinct Outcomes in Colon Cancer

Other · June 17, 2026 <p>This Figure is a visual summary of this work’s findings and shows the spatial distribution of distinct macrophage subsets in the tumor microenvironment and the clinical significance of IL4I1+ and SPP1+ macrophages in breast and colon tumor ... Full text Cite

Figure S4 from Spatially Segregated Macrophage Populations Predict Distinct Outcomes in Colon Cancer

Other · June 17, 2026 <p>This Figure shows protein marker expression across different cell types detected in CODEX experiment, macrophage distance to the closest tumor cell, macrophage distribution across different tissue niches, and tissue niche distribution acro ... Full text Cite

Figure S8 from Spatially Segregated Macrophage Populations Predict Distinct Outcomes in Colon Cancer

Other · June 17, 2026 <p>This Figure shows Kaplan-Meier plots of CRC patient samples stratified by IL4I1+ macrophage counts.</p> ... Full text Cite

Table S1 from Spatially Segregated Macrophage Populations Predict Distinct Outcomes in Colon Cancer

Other · June 17, 2026 <p>Supplementary Table 1. List of IHC antibodies</p> ... Full text Cite

Table S2 from Spatially Segregated Macrophage Populations Predict Distinct Outcomes in Colon Cancer

Other · June 17, 2026 <p>Supplementary Table 2. List of CODEX antibodies</p> ... Full text Cite

Figure S6 from Spatially Segregated Macrophage Populations Predict Distinct Outcomes in Colon Cancer

Other · June 17, 2026 <p>This Figure shows the spatial interaction of FOLR2+ macrophages with Plasma Cells in normal colon lamina propria, normal breast, normal lymph node, and breast cancer adjacent normal tissue. It also illustrates ligand-receptor interactions ... Full text Cite

Figure S5 from Spatially Segregated Macrophage Populations Predict Distinct Outcomes in Colon Cancer

Other · June 17, 2026 <p>Thus Figure illustrates how macrophage subsets detected using scRNAseq, 4-color IF, and CODEX correspond to each other and shows representative examples of protein marker expression across macrophage niches.</p> ... Full text Cite

Table S3 from Spatially Segregated Macrophage Populations Predict Distinct Outcomes in Colon Cancer

Other · June 17, 2026 <p>Supplementary Table 3. CODEX imiging cycles record</p> ... Full text Cite

Figure S1 from Spatially Segregated Macrophage Populations Predict Distinct Outcomes in Colon Cancer

Other · June 17, 2026 <p>This Figure shows the distribution of scRNAseq macrophage clusters across different datasets, tissue locations, and tumor types.</p> ... Full text Cite

Figure S2 from Spatially Segregated Macrophage Populations Predict Distinct Outcomes in Colon Cancer

Other · June 17, 2026 <p>This Figure illustrates spatial segregation of IL4I1+ vs FOLR2+ macrophages in BC and CRC tumor metastasis to the LN, and across eight different tumor types.</p> ... Full text Cite

Data from Spatially Segregated Macrophage Populations Predict Distinct Outcomes in Colon Cancer

Other · August 2, 2024 <div>Abstract<p>Tumor-associated macrophages are transcriptionally heterogeneous, but the spatial distribution and cell interactions that shape macrophage tissue roles remain poorly characterized. Here, we spatially resolve five distinc ... Full text Cite

Table S1 from Spatially Segregated Macrophage Populations Predict Distinct Outcomes in Colon Cancer

Other · August 2, 2024 <p>Supplementary Table 1. List of IHC antibodies</p> ... Full text Cite

Figure S8 from Spatially Segregated Macrophage Populations Predict Distinct Outcomes in Colon Cancer

Other · August 2, 2024 <p>This Figure shows Kaplan-Meier plots of CRC patient samples stratified by IL4I1+ macrophage counts.</p> ... Full text Cite

Figure S5 from Spatially Segregated Macrophage Populations Predict Distinct Outcomes in Colon Cancer

Other · August 2, 2024 <p>Thus Figure illustrates how macrophage subsets detected using scRNAseq, 4-color IF, and CODEX correspond to each other and shows representative examples of protein marker expression across macrophage niches.</p> ... Full text Cite

Figure S4 from Spatially Segregated Macrophage Populations Predict Distinct Outcomes in Colon Cancer

Other · August 2, 2024 <p>This Figure shows protein marker expression across different cell types detected in CODEX experiment, macrophage distance to the closest tumor cell, macrophage distribution across different tissue niches, and tissue niche distribution acro ... Full text Cite

Figure S8 from Spatially Segregated Macrophage Populations Predict Distinct Outcomes in Colon Cancer

Other · August 2, 2024 <p>This Figure shows Kaplan-Meier plots of CRC patient samples stratified by IL4I1+ macrophage counts.</p> ... Full text Cite

Figure S2 from Spatially Segregated Macrophage Populations Predict Distinct Outcomes in Colon Cancer

Other · August 2, 2024 <p>This Figure illustrates spatial segregation of IL4I1+ vs FOLR2+ macrophages in BC and CRC tumor metastasis to the LN, and across eight different tumor types.</p> ... Full text Cite

Figure S1 from Spatially Segregated Macrophage Populations Predict Distinct Outcomes in Colon Cancer

Other · August 2, 2024 <p>This Figure shows the distribution of scRNAseq macrophage clusters across different datasets, tissue locations, and tumor types.</p> ... Full text Cite

Figure S6 from Spatially Segregated Macrophage Populations Predict Distinct Outcomes in Colon Cancer

Other · August 2, 2024 <p>This Figure shows the spatial interaction of FOLR2+ macrophages with Plasma Cells in normal colon lamina propria, normal breast, normal lymph node, and breast cancer adjacent normal tissue. It also illustrates ligand-receptor interactions ... Full text Cite

Table S3 from Spatially Segregated Macrophage Populations Predict Distinct Outcomes in Colon Cancer

Other · August 2, 2024 <p>Supplementary Table 3. CODEX imiging cycles record</p> ... Full text Cite

Table S1 from Spatially Segregated Macrophage Populations Predict Distinct Outcomes in Colon Cancer

Other · August 2, 2024 <p>Supplementary Table 1. List of IHC antibodies</p> ... Full text Cite

Figure S9 from Spatially Segregated Macrophage Populations Predict Distinct Outcomes in Colon Cancer

Other · August 2, 2024 <p>This Figure is a visual summary of this work’s findings and shows the spatial distribution of distinct macrophage subsets in the tumor microenvironment and the clinical significance of IL4I1+ and SPP1+ macrophages in breast and colon tumor ... Full text Cite

Figure S4 from Spatially Segregated Macrophage Populations Predict Distinct Outcomes in Colon Cancer

Other · August 2, 2024 <p>This Figure shows protein marker expression across different cell types detected in CODEX experiment, macrophage distance to the closest tumor cell, macrophage distribution across different tissue niches, and tissue niche distribution acro ... Full text Cite

Figure S6 from Spatially Segregated Macrophage Populations Predict Distinct Outcomes in Colon Cancer

Other · August 2, 2024 <p>This Figure shows the spatial interaction of FOLR2+ macrophages with Plasma Cells in normal colon lamina propria, normal breast, normal lymph node, and breast cancer adjacent normal tissue. It also illustrates ligand-receptor interactions ... Full text Cite

Data from Spatially Segregated Macrophage Populations Predict Distinct Outcomes in Colon Cancer

Other · August 2, 2024 <div>Abstract<p>Tumor-associated macrophages are transcriptionally heterogeneous, but the spatial distribution and cell interactions that shape macrophage tissue roles remain poorly characterized. Here, we spatially resolve five distinc ... Full text Cite

Table S3 from Spatially Segregated Macrophage Populations Predict Distinct Outcomes in Colon Cancer

Other · August 2, 2024 <p>Supplementary Table 3. CODEX imiging cycles record</p> ... Full text Cite

Figure S1 from Spatially Segregated Macrophage Populations Predict Distinct Outcomes in Colon Cancer

Other · August 2, 2024 <p>This Figure shows the distribution of scRNAseq macrophage clusters across different datasets, tissue locations, and tumor types.</p> ... Full text Cite

Figure S3 from Spatially Segregated Macrophage Populations Predict Distinct Outcomes in Colon Cancer

Other · August 2, 2024 <p>Thus Figure shows CD274 gene scRNAseq expression across different cell types and datasets.</p> ... Full text Cite

Figure S5 from Spatially Segregated Macrophage Populations Predict Distinct Outcomes in Colon Cancer

Other · August 2, 2024 <p>Thus Figure illustrates how macrophage subsets detected using scRNAseq, 4-color IF, and CODEX correspond to each other and shows representative examples of protein marker expression across macrophage niches.</p> ... Full text Cite

Table S2 from Spatially Segregated Macrophage Populations Predict Distinct Outcomes in Colon Cancer

Other · August 2, 2024 <p>Supplementary Table 2. List of CODEX antibodies</p> ... Full text Cite

Figure S7 from Spatially Segregated Macrophage Populations Predict Distinct Outcomes in Colon Cancer

Other · August 2, 2024 <p>Thus Figure shows spatial enrichment of NLRP3+ macrophages with neutrophils in Crohn’s Disease, and immunostimulatory and immunosuppressive protein marker expression in NLRP3+ vs SPP1+ macrophages.</p> ... Full text Cite

Figure S9 from Spatially Segregated Macrophage Populations Predict Distinct Outcomes in Colon Cancer

Other · August 2, 2024 <p>This Figure is a visual summary of this work’s findings and shows the spatial distribution of distinct macrophage subsets in the tumor microenvironment and the clinical significance of IL4I1+ and SPP1+ macrophages in breast and colon tumor ... Full text Cite

Table S2 from Spatially Segregated Macrophage Populations Predict Distinct Outcomes in Colon Cancer

Other · August 2, 2024 <p>Supplementary Table 2. List of CODEX antibodies</p> ... Full text Cite

Figure S3 from Spatially Segregated Macrophage Populations Predict Distinct Outcomes in Colon Cancer

Other · August 2, 2024 <p>Thus Figure shows CD274 gene scRNAseq expression across different cell types and datasets.</p> ... Full text Cite

Figure S2 from Spatially Segregated Macrophage Populations Predict Distinct Outcomes in Colon Cancer

Other · August 2, 2024 <p>This Figure illustrates spatial segregation of IL4I1+ vs FOLR2+ macrophages in BC and CRC tumor metastasis to the LN, and across eight different tumor types.</p> ... Full text Cite

Figure S7 from Spatially Segregated Macrophage Populations Predict Distinct Outcomes in Colon Cancer

Other · August 2, 2024 <p>Thus Figure shows spatial enrichment of NLRP3+ macrophages with neutrophils in Crohn’s Disease, and immunostimulatory and immunosuppressive protein marker expression in NLRP3+ vs SPP1+ macrophages.</p> ... Full text Cite