John Wilson Schmitt

Journal article Cancer Epidemiol Biomarkers Prev · August 2, 2022 BACKGROUND: High-risk human papillomavirus (hrHPV) testing is utilized in primary cervical cancer screening, generally along with cytology, to triage abnormalities to colposcopy. Most screening-based hrHPV testing involves pooled detection of any hrHPV or ... Full text Link to item Cite

Extended HPV Genotyping to Compare HPV Type Distribution in Self- and Provider-Collected Samples for Cervical Cancer Screening.

Journal article Cancer Epidemiol Biomarkers Prev · December 2020 BACKGROUND: Primary high-risk human papillomavirus (hr-HPV) testing of self-collected cervico-vaginal swabs could increase cervical cancer screening coverage, although triage strategies are needed to reduce unnecessary colposcopies. We evaluated the use of ... Full text Link to item Cite

A novel speculum-free imaging strategy for visualization of the internal female lower reproductive system.

Journal article Sci Rep · October 6, 2020 Fear of the speculum and feelings of vulnerability during the gynecologic exams are two of the biggest barriers to cervical cancer screening for women. To address these barriers, we have developed a novel, low-cost tool called the Callascope to reimagine t ... Full text Link to item Cite

Racial and Ethnic Differences in Acceptability of Urine and Cervico-Vaginal Sample Self-Collection for HPV-Based Cervical Cancer Screening.

Journal article J Womens Health (Larchmt) · July 2020 Background: We compared women's acceptability of urine and cervico-vaginal sample self-collection for high-risk (oncogenic) human papillomavirus (hrHPV) testing and assessed whether acceptability varied across racial/ethnic groups. Methods: As part of a te ... Full text Link to item Cite

Test Accuracy of Human Papillomavirus in Urine for Detection of Cervical Intraepithelial Neoplasia.

Journal article J Clin Microbiol · February 24, 2020 The objective was to assess the diagnostic test accuracy of high-risk human papillomavirus (hrHPV) testing of self-collected urine and cervicovaginal samples for the detection of cervical intraepithelial neoplasia grade 2 or higher (CIN2+). We recruited a ... Full text Link to item Cite

Development of Algorithms for Automated Detection of Cervical Pre-Cancers With a Low-Cost, Point-of-Care, Pocket Colposcope.

Journal article IEEE Trans Biomed Eng · August 2019 GOAL: In this paper, we propose methods for (1) automatic feature extraction and classification for acetic acid and Lugol's iodine cervigrams and (2) methods for combining features/diagnosis of different contrasts in cervigrams for improved performance. ME ... Full text Link to item Cite

Using fetal scalp stimulation with Doppler ultrasonography to enhance intermittent auscultation in low-resource settings: a diagnostic trial from Tanzania.

Journal article BMC Pregnancy Childbirth · February 13, 2019 BACKGROUND: Hypoxia during labor contributes to 2.2 million intrapartum and early neonatal deaths each year. An additional 0.6-1.0 million cases of life-long disability occur because of fetal hypoxia during labor. It is known that fetal heart rate changes ... Full text Open Access Link to item Cite

Portable Pocket colposcopy performs comparably to standard-of-care clinical colposcopy using acetic acid and Lugol's iodine as contrast mediators: an investigational study in Peru.

Journal article BJOG · September 2018 OBJECTIVE: Our goal was to develop a tele-colposcopy platform for primary-care clinics to improve screening sensitivity and access. Specifically, we developed a low-cost, portable Pocket colposcope and evaluated its performance in a tertiary healthcare cen ... Full text Open Access Link to item Cite

An integrated strategy for improving contrast, durability, and portability of a Pocket Colposcope for cervical cancer screening and diagnosis.

Journal article PLoS One · 2018 INTRODUCTION: We have previously developed a portable Pocket Colposcope for cervical cancer screening in resource-limited settings. In this manuscript we report two different strategies (cross-polarization and an integrated reflector) to improve image cont ... Full text Link to item Cite

International Image Concordance Study to Compare a Point-of-Care Tampon Colposcope With a Standard-of-Care Colposcope.

Journal article J Low Genit Tract Dis · April 2017 OBJECTIVE: Barriers to cervical cancer screening in low-resource settings include lack of accessible, high-quality services, high cost, and the need for multiple visits. To address these challenges, we developed a low-cost, intravaginal, optical cervical i ... Full text Open Access Link to item Cite

Design and preliminary analysis of a vaginal inserter for speculum-free cervical cancer screening.

Journal article PLoS One · 2017 OBJECTIVE: Cervical cancer screening usually requires use of a speculum to provide a clear view of the cervix. The speculum is one potential barrier to screening due to fear of pain, discomfort and embarrassment. The aim of this paper is to present and dem ... Full text Link to item Cite

The Bakri tamponade balloon as an adjunct treatment for refractory postpartum hemorrhage.

Journal article Int J Gynaecol Obstet · December 2016 OBJECTIVE: To evaluate the Bakri tamponade balloon as an adjunct treatment for refractory postpartum hemorrhage (PPH). METHODS: A prospective observational intervention study was conducted between January 1, 2013, and May 31, 2015, at Great Lakes Hospital ... Full text Link to item Cite

Design of a Novel Low Cost Point of Care Tampon (POCkeT) Colposcope for Use in Resource Limited Settings.

Journal article PLoS One · 2015 INTRODUCTION: Current guidelines by WHO for cervical cancer screening in low- and middle-income countries involves visual inspection with acetic acid (VIA) of the cervix, followed by treatment during the same visit or a subsequent visit with cryotherapy if ... Full text Open Access Link to item Cite

Direct fluorescent antibody testing for endocervical Chlamydia trachomatis: factors affecting accuracy.

Journal article Obstet Gynecol · November 1988 Endocervical swabbings obtained after two previous cleansing swabs from 202 women with indications for testing for genital chlamydial infection were evaluated for the presence of Chlamydia trachomatis by culture and two direct fluorescent monoclonal antibo ... Link to item Cite

Inhibition of protein synthesis also inhibits synthesis of lipid-linked oligosaccharides.

Journal article J Biol Chem · December 25, 1979 Studies were initiated to determine whether the formation of lipid-linked oligosaccharides was coupled to the synthesis of protein. Canine kidney cells were grown with [2-3H]mannose or [3H]leucine in the presence of cycloheximide or puromycin and the effec ... Link to item Cite

Adherence of bacteria to mammalian cells: inhibition by tunicamycin and streptovirudin.

Journal article J Bacteriol · August 1979 Group B streptococci were labeled either by growing the cells in [14C]fructose or by using the surface label 4,4'-[3H]diisothiocyano-1,2-diphenylethane-2,2'-disulfonic acid, which reacts with amino groups. A quantitative assay was developed by using these ... Full text Link to item Cite